|
Name |
Accession |
Description |
Interval |
E-value |
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
119-742 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 567.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 119 YLSAVRLYDTYVLRTMGTEPVYESVAQMFMRVSVfvacqcleheCLYWLARDliedaksVSEMAIVEYVFGYLAAQHVCC 198
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESPQEAYMRVAM----------GLASLEPK-------DTRLADAIRFYDLLSRLKISP 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 199 ATPILRSAGVEGGQLASCFILQPsMMNEPGTLDALYHDMSPLLASKSGVGLDVTSFS-----------HQKNIASCLKLV 267
Cdd:TIGR02506 64 ATPTLFNAGTPRGQLSSCFLLDV-TDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRaigspirgtnnASKGIIPFLKLL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 268 DAQVHYFNDNNIRPVGASAYMELWHSQICDFLNAKLP--ENPDRCHSLFQGVCIPTLFFRMYEKDpsKLWYLFDPATAPN 345
Cdd:TIGR02506 143 DSSVEAVNQGGKRPGAAAVYLEVWHPDIEEFLDLKKNngDERRRCDNLFYGLWIPDLFMKRVEED--KDWYLFSPYDVPG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 346 LIKLYGAAFDNEYERLVRAGKYV---SCMPLKSMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMAINCSNLCAEIVQ 422
Cdd:TIGR02506 221 LYGLYGEEFEEEYERLEKDVEARkkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQ 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 423 LPGR----NTSVCNLANICLPKCLrtvesarvgttdaNRPFFCFEALGDAVRVAVLVINACILGGSHPT-PGVERGQKER 497
Cdd:TIGR02506 301 PTDDshkgETAVCNLASVNLANFV-------------MEDKFDFSELEDAVRIAVRFLDNVIDLQNYPTaPAAKSNQRRR 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 498 SMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEgQGvPFHGWEVSNFAKGRFHWQTWEGEDAS 577
Cdd:TIGR02506 368 SIGIGVMGLHDVLAKLGLPYDSEEARDLNDRIFEAIYYYAIKASAELAKE-KG-PFPGFSGSKYAKGWLHPDTWEKTIDP 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 578 FVPRH----RWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKVTNKEEVLRPNVTFFKKVLPDDL 653
Cdd:TIGR02506 446 KTSMApteeDWEALRERIKEYGLRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGL 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 654 RVVRQYGGDVS--TFPKH----HRERYRVFLTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHG 727
Cdd:TIGR02506 526 WDADRRGDIVEnvGSPQPiaaiPETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEE--VTAKDLLKLLLLA 603
|
650
....*....|....*
gi 139472880 728 YRLGLKTlMYYCRVQ 742
Cdd:TIGR02506 604 WKKGLKT-MYYCRSR 617
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
214-738 |
1.88e-155 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 461.68 E-value: 1.88e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 214 ASCFILQP--SMmnePGTLDAlYHDMSPLLASKSGVGLDV------------TSFSHqKNIASCLKLVDAQVHYFNDNNI 279
Cdd:pfam02867 1 SSCFLLSVedSL---DSIYDT-LKEAALLSKGGGGIGLNLsklrakgspirgTGGAS-SGVVPFLKLFDDSARYVNQGGK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 280 RPVGASAYMELWHSQICDFLNAKlPENPD---RCHSLFQGVCIPTLFFRMYEKDpsKLWYLFDPATAPNLIKLYGAAFDN 356
Cdd:pfam02867 76 RRGAAAVYLEVWHPDIEEFLDLK-KNNGDeevRARNLNLGVWVPDLFMERVEAD--EDWTLFSPREAPDLEDLYGEEFEK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 357 E-YERLVRAGKYVSCMPLKSMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMaINCSNLCAEIVQLP-GRNTSVCNLA 434
Cdd:pfam02867 153 EyYEREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGT-IKSSNLCTEIVQPTsPSEIAVCNLA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 435 NICLPKCLRtvesarvgttdaNRPFFCFEALGDAVRVAVLVINACILGGSHPTPGVERG-QKERSMGIGVQGLADVFAEL 513
Cdd:pfam02867 232 SINLAKFVE------------FGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSnKRHRPIGLGVMGLADALAKL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 514 GYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEGQgvPFHGWEVSNFAKGRFHWQTWEGEDASFVP---RHRWDALGKS 590
Cdd:pfam02867 300 GIPYDSEEARDLNDKIFETMYYYALKASSELAKEKG--PFPGFEGSKYSKGILQFDKYVKTDFAPKAsktREDWEELRED 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 591 IAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKVTNKEEVlrpnvtffkkvlpddlrvvrqyggdvstfpkhh 670
Cdd:pfam02867 378 IKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLSEET--------------------------------- 424
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 139472880 671 rerYRVFLTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHGYRLGLKTLMYY 738
Cdd:pfam02867 425 ---KEYYKTAYDIDQKAHIDMAAARQPFVDQSISKTLFLPND--ATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
88-740 |
8.62e-103 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 330.99 E-value: 8.62e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 88 ESFIQKNIDALEDMLCAYRRSKAyedtlncGYLSAVRLYDTYVLRTM-GTepVYESVAQMFMRVSVFVACQCLEHECLYW 166
Cdd:COG0209 27 ERLLEEDLEELAAAIDPERDRFF-------SYNALKTLYDRYLLKDEdGK--PLETPQDLFMRVAMGLAAAEKPEDREEW 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 167 lARDLIEdaksvsemaiveyvfgYLAAQHVCCATPILRSAGVEGGQLASCFILQP--SMmnePGTLDALYHDMsplLASK 244
Cdd:COG0209 98 -AKEFYD----------------LLSSLRFLPATPTLFNAGTPRGQLSSCFVLPVedSL---ESIFDALKDAA---LLSK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 245 S--GVGLDVTSF----SHQKNIA-------SCLKLVDAQVHYFNDNNIRPvGA-SAYMELWHSQICDFLNAKLpENPD-- 308
Cdd:COG0209 155 SggGVGFNFSRLrpkgSPIKGTGgvssgpvPFMKVFDDAAVAVNQGGKRR-GAnMVYLRVWHPDIEEFLDLKK-NNGDer 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 309 -RCHSLFQGVCIPTLFFRMYEKDpsKLWYLFDPATAPNLIKLYGAAFDNEYERLVRAGKYVSCMPLKSMMFTLIHTIIKT 387
Cdd:COG0209 233 rRLHNFNISVWIPDLFMEAVEED--EDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAWET 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 388 GSPYVLLKEALNEHHWTDTQGMaINCSNLCAEIVQLP-GRNTSVCNLANICLPKCLRTVEsarvgttdanrpfFCFEALG 466
Cdd:COG0209 311 GEPGILFKDTINRRNPLPHLGV-IHSSNLCGEIPLLPyESEDASCNLGSINLAKFVKDGE-------------FDWEKLE 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 467 DAVRVAVL----VINAcilgGSHPTPGVERG-QKERSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETS 541
Cdd:COG0209 377 ETVRTAVRfldnVIDI----NDYPVPEIEKAnRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKAS 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 542 HNLVLEgQGvPFHGWEVSNFAKGRFHWQTWEgEDASFVPRHRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVY 621
Cdd:COG0209 453 AELAKE-RG-AFPAFEGSKYAKGILPFDKYL-DDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIE 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 622 PFFANISSK-VTNKEEVLRPNvTFFKKVL------PDDLRVVRQYGGDVSTFPKHHRERYRVFLTAFDYCPFKLLDRARA 694
Cdd:COG0209 530 PIFSLVYVRkVLDGGEFTVVN-PYLVRALkelglwDEELVEKIKEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAA 608
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 139472880 695 RAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHGYRLGLKTLmYYCR 740
Cdd:COG0209 609 RQKHVDQAISKTLNLPND--ATVEDLAELYLLAWKLGLKGI-YYYR 651
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
77-792 |
8.29e-80 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 273.16 E-value: 8.29e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 77 GIFRGVLGHRVESFIQKNIDALEDMLcAYRRSKAYEdtlncgYLSAVRLYDTYVLRTMGTepVYESVAQMFMRVSVFVac 156
Cdd:PLN02437 110 GLKAPLIADDVYDIIMKNAARLDSEI-IYDRDFDYD------YFGFKTLERSYLLKVNGK--VVERPQHMLMRVSVGI-- 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 157 qcleHEclywlardliEDAKSvsemAIVEYvfgYLAAQ----HvccATPILRSAGVEGGQLASCFILQpsmMNEpGTLDA 232
Cdd:PLN02437 179 ----HK----------DDIES----AIKTY---HLMSQrwftH---ASPTLFNAGTPRPQLSSCFLIC---MKD-DSIEG 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 233 LYHDMSPL-LASKS--GVGLDV------TSFSHQKN-----IASCLKLVDAQVHYFNDNNIRPVGASA-YMELWHSQICD 297
Cdd:PLN02437 231 IYDTLKECaVISKSagGIGLSVhniratGSYIRGTNgtsngIVPMLRVFNDTARYVDQGGGKRKGAFAiYLEPWHADIFE 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 298 FLNakLPEN----PDRCHSLFQGVCIPTLFFRMYEKDpsKLWYLFDPATAPNLIKLYGAAFDNEYERLVRAGKYVSCMPL 373
Cdd:PLN02437 311 FLD--LRKNhgkeEHRARDLFYALWIPDLFMERVQSN--GDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQA 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 374 KSMMFTLIHTIIKTGSPYVLLKEALNEHhwTDTQGMA-INCSNLCAEIVQLPG-RNTSVCNLANICLPKCLR-------T 444
Cdd:PLN02437 387 QQLWFAILESQIETGTPYMLFKDSCNRK--SNQQNLGtIKSSNLCTEIIEYTSpTETAVCNLASIALPRFVRekgvpleS 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 445 VESARVGTTDANRPFFCFEALGDAVRVAVLVINACILGGSHPTPGVERGQ-KERSMGIGVQGLADVFAELGYGYLDAESA 523
Cdd:PLN02437 465 HPSKLVGSLGSKNRYFDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNmRHRPIGIGVQGLADAFILLGMPFDSPEAQ 544
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 524 ELDKNIFQSMYYTAVETSHNL-VLEGqgvPFHGWEVSNFAKGRFHWQTWEGEDASfvpRHRWDALGKSIAEHGIFNSQFL 602
Cdd:PLN02437 545 QLNKDIFETIYYHALKASSELaAREG---PYETYAGSPVSKGILQPDMWGVTPSG---RWDWAALREMISKNGVRNSLLV 618
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 603 AVMPTAGTSQVTGYAESVYPFFANISSKvtnkeEVLRPNVTFFKKVLPDDL------------RVVRQYGG--DVSTFPK 668
Cdd:PLN02437 619 APMPTASTSQILGNNECFEPYTSNIYSR-----RVLSGEFVVVNKHLLHDLtemglwtptlknKIIAENGSvqKIPEIPD 693
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 669 HHRERYRvflTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDrvrNASYLRDLLLHGYRLGLKTLMYYCRvqKQSSLT 748
Cdd:PLN02437 694 DLKAIYK---TVWEIKQRTLVDMAADRGCYIDQSQSLNIHMDQP---NFGKLTSLHFYAWSKGLKTGMYYLR--SRAAAD 765
|
730 740 750 760
....*....|....*....|....*....|....*....|....
gi 139472880 749 ALQCLADPGSPPHSgmkqdgawLPGPKNPEEESCAADPECLVCQ 792
Cdd:PLN02437 766 AIKFTVDTASLKPS--------ATGVAAPEEEDVETKMAQMVCS 801
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
145-740 |
1.97e-72 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 243.99 E-value: 1.97e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 145 QMFMRVSVFVACQCLEHeclywlARDLIEdaksvsemaiveyvfgYLAAQHVCCATPILRSAGVEGGQLASCFILQPsmm 224
Cdd:cd01679 3 DRLMRVALGLASGDLEW------AKEFYD----------------LLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV--- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 225 nePGTLDALYHD-MSPLLASKS--GVGLDVTSF----SHQKNI--AS-----CLKLVDAQVHYFNDNNIRPvGASA-YME 289
Cdd:cd01679 58 --DDSLESIYDTiKECAQLSKIggGIGLNLSNIratgSPIRGTngASngvipFLKLLNDTARYVDQGGQRK-GAGAvYLE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 290 LWHSQICDFLNAKLPENPD--RCHSLFQGVCIPTLFFRMYEKDpskLWYlfdpatapnliklygaafdneyerlvragky 367
Cdd:cd01679 135 IWHPDIEEFLDLKKNNGDErrRARDLFYGVWIPDLFMERVERD---LWR------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 368 vscmplksmmfTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMaINCSNLCAEIVQ------LPGRNTSVCNLANICLPkc 441
Cdd:cd01679 181 -----------KILESQFETGYPYILFKDTCNRKNPQKHLGT-IKSSNLCTEILQptspseDEPGEDAVCNLASINLG-- 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 442 lRTVEsarvgttdanrpffcFEALGDAVRVAVLVINACILGGSHPTPGVERG-QKERSMGIGVQGLADVFAELGYGYLDA 520
Cdd:cd01679 247 -NFVT---------------FEKLEEVVKLAVRALDNVIDLNYYPVPEAKRSnMRHRAIGLGVMGLHDYLALLRIPYESE 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 521 ESAELDKNIFQSMYYTAVETSHNLVLEgqgvpfhgwevsnfaKGrfhwqtwegedasfvprhrwdalgksiaehGIFNSQ 600
Cdd:cd01679 311 EALDLNDRIFETINYYALKASCELAKE---------------RG------------------------------GLRNSL 345
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 601 FLAVMPTAGTSQVTGYAESVYPFFANISSKVTNKEEVLRPNvtffkKVLPDDLrvvrqyggdvstfpkhhrERYRVFLTA 680
Cdd:cd01679 346 LLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVN-----PHLEKDL------------------WEYGLYKTA 402
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 681 FDYCPFKLLDRARARAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHGYRLGLKTLmYYCR 740
Cdd:cd01679 403 YEIDQRWLIDLAADRQKHIDQGQSLNLFLTPP--ATTRDLNSLYFYAWKKGLKTL-YYLR 459
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
119-742 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 567.78 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 119 YLSAVRLYDTYVLRTMGTEPVYESVAQMFMRVSVfvacqcleheCLYWLARDliedaksVSEMAIVEYVFGYLAAQHVCC 198
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESPQEAYMRVAM----------GLASLEPK-------DTRLADAIRFYDLLSRLKISP 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 199 ATPILRSAGVEGGQLASCFILQPsMMNEPGTLDALYHDMSPLLASKSGVGLDVTSFS-----------HQKNIASCLKLV 267
Cdd:TIGR02506 64 ATPTLFNAGTPRGQLSSCFLLDV-TDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRaigspirgtnnASKGIIPFLKLL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 268 DAQVHYFNDNNIRPVGASAYMELWHSQICDFLNAKLP--ENPDRCHSLFQGVCIPTLFFRMYEKDpsKLWYLFDPATAPN 345
Cdd:TIGR02506 143 DSSVEAVNQGGKRPGAAAVYLEVWHPDIEEFLDLKKNngDERRRCDNLFYGLWIPDLFMKRVEED--KDWYLFSPYDVPG 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 346 LIKLYGAAFDNEYERLVRAGKYV---SCMPLKSMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMAINCSNLCAEIVQ 422
Cdd:TIGR02506 221 LYGLYGEEFEEEYERLEKDVEARkkiRKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKTGGGAIKMSNLCTEITQ 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 423 LPGR----NTSVCNLANICLPKCLrtvesarvgttdaNRPFFCFEALGDAVRVAVLVINACILGGSHPT-PGVERGQKER 497
Cdd:TIGR02506 301 PTDDshkgETAVCNLASVNLANFV-------------MEDKFDFSELEDAVRIAVRFLDNVIDLQNYPTaPAAKSNQRRR 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 498 SMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEgQGvPFHGWEVSNFAKGRFHWQTWEGEDAS 577
Cdd:TIGR02506 368 SIGIGVMGLHDVLAKLGLPYDSEEARDLNDRIFEAIYYYAIKASAELAKE-KG-PFPGFSGSKYAKGWLHPDTWEKTIDP 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 578 FVPRH----RWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKVTNKEEVLRPNVTFFKKVLPDDL 653
Cdd:TIGR02506 446 KTSMApteeDWEALRERIKEYGLRNSQLTALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGL 525
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 654 RVVRQYGGDVS--TFPKH----HRERYRVFLTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHG 727
Cdd:TIGR02506 526 WDADRRGDIVEnvGSPQPiaaiPETLKYKYKTAYELDQEALIDMAADRQKFVDQSISLNLFLTEE--VTAKDLLKLLLLA 603
|
650
....*....|....*
gi 139472880 728 YRLGLKTlMYYCRVQ 742
Cdd:TIGR02506 604 WKKGLKT-MYYCRSR 617
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
214-738 |
1.88e-155 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 461.68 E-value: 1.88e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 214 ASCFILQP--SMmnePGTLDAlYHDMSPLLASKSGVGLDV------------TSFSHqKNIASCLKLVDAQVHYFNDNNI 279
Cdd:pfam02867 1 SSCFLLSVedSL---DSIYDT-LKEAALLSKGGGGIGLNLsklrakgspirgTGGAS-SGVVPFLKLFDDSARYVNQGGK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 280 RPVGASAYMELWHSQICDFLNAKlPENPD---RCHSLFQGVCIPTLFFRMYEKDpsKLWYLFDPATAPNLIKLYGAAFDN 356
Cdd:pfam02867 76 RRGAAAVYLEVWHPDIEEFLDLK-KNNGDeevRARNLNLGVWVPDLFMERVEAD--EDWTLFSPREAPDLEDLYGEEFEK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 357 E-YERLVRAGKYVSCMPLKSMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMaINCSNLCAEIVQLP-GRNTSVCNLA 434
Cdd:pfam02867 153 EyYEREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGT-IKSSNLCTEIVQPTsPSEIAVCNLA 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 435 NICLPKCLRtvesarvgttdaNRPFFCFEALGDAVRVAVLVINACILGGSHPTPGVERG-QKERSMGIGVQGLADVFAEL 513
Cdd:pfam02867 232 SINLAKFVE------------FGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSnKRHRPIGLGVMGLADALAKL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 514 GYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEGQgvPFHGWEVSNFAKGRFHWQTWEGEDASFVP---RHRWDALGKS 590
Cdd:pfam02867 300 GIPYDSEEARDLNDKIFETMYYYALKASSELAKEKG--PFPGFEGSKYSKGILQFDKYVKTDFAPKAsktREDWEELRED 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 591 IAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKVTNKEEVlrpnvtffkkvlpddlrvvrqyggdvstfpkhh 670
Cdd:pfam02867 378 IKKYGLRNSQLTAIAPTGSISQIAGATESIEPIFSNVYSRKVLSEET--------------------------------- 424
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 139472880 671 rerYRVFLTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHGYRLGLKTLMYY 738
Cdd:pfam02867 425 ---KEYYKTAYDIDQKAHIDMAAARQPFVDQSISKTLFLPND--ATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
88-740 |
8.62e-103 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 330.99 E-value: 8.62e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 88 ESFIQKNIDALEDMLCAYRRSKAyedtlncGYLSAVRLYDTYVLRTM-GTepVYESVAQMFMRVSVFVACQCLEHECLYW 166
Cdd:COG0209 27 ERLLEEDLEELAAAIDPERDRFF-------SYNALKTLYDRYLLKDEdGK--PLETPQDLFMRVAMGLAAAEKPEDREEW 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 167 lARDLIEdaksvsemaiveyvfgYLAAQHVCCATPILRSAGVEGGQLASCFILQP--SMmnePGTLDALYHDMsplLASK 244
Cdd:COG0209 98 -AKEFYD----------------LLSSLRFLPATPTLFNAGTPRGQLSSCFVLPVedSL---ESIFDALKDAA---LLSK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 245 S--GVGLDVTSF----SHQKNIA-------SCLKLVDAQVHYFNDNNIRPvGA-SAYMELWHSQICDFLNAKLpENPD-- 308
Cdd:COG0209 155 SggGVGFNFSRLrpkgSPIKGTGgvssgpvPFMKVFDDAAVAVNQGGKRR-GAnMVYLRVWHPDIEEFLDLKK-NNGDer 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 309 -RCHSLFQGVCIPTLFFRMYEKDpsKLWYLFDPATAPNLIKLYGAAFDNEYERLVRAGKYVSCMPLKSMMFTLIHTIIKT 387
Cdd:COG0209 233 rRLHNFNISVWIPDLFMEAVEED--EDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAWET 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 388 GSPYVLLKEALNEHHWTDTQGMaINCSNLCAEIVQLP-GRNTSVCNLANICLPKCLRTVEsarvgttdanrpfFCFEALG 466
Cdd:COG0209 311 GEPGILFKDTINRRNPLPHLGV-IHSSNLCGEIPLLPyESEDASCNLGSINLAKFVKDGE-------------FDWEKLE 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 467 DAVRVAVL----VINAcilgGSHPTPGVERG-QKERSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETS 541
Cdd:COG0209 377 ETVRTAVRfldnVIDI----NDYPVPEIEKAnRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKAS 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 542 HNLVLEgQGvPFHGWEVSNFAKGRFHWQTWEgEDASFVPRHRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVY 621
Cdd:COG0209 453 AELAKE-RG-AFPAFEGSKYAKGILPFDKYL-DDLLIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIE 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 622 PFFANISSK-VTNKEEVLRPNvTFFKKVL------PDDLRVVRQYGGDVSTFPKHHRERYRVFLTAFDYCPFKLLDRARA 694
Cdd:COG0209 530 PIFSLVYVRkVLDGGEFTVVN-PYLVRALkelglwDEELVEKIKEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAA 608
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 139472880 695 RAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHGYRLGLKTLmYYCR 740
Cdd:COG0209 609 RQKHVDQAISKTLNLPND--ATVEDLAELYLLAWKLGLKGI-YYYR 651
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
77-792 |
8.29e-80 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 273.16 E-value: 8.29e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 77 GIFRGVLGHRVESFIQKNIDALEDMLcAYRRSKAYEdtlncgYLSAVRLYDTYVLRTMGTepVYESVAQMFMRVSVFVac 156
Cdd:PLN02437 110 GLKAPLIADDVYDIIMKNAARLDSEI-IYDRDFDYD------YFGFKTLERSYLLKVNGK--VVERPQHMLMRVSVGI-- 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 157 qcleHEclywlardliEDAKSvsemAIVEYvfgYLAAQ----HvccATPILRSAGVEGGQLASCFILQpsmMNEpGTLDA 232
Cdd:PLN02437 179 ----HK----------DDIES----AIKTY---HLMSQrwftH---ASPTLFNAGTPRPQLSSCFLIC---MKD-DSIEG 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 233 LYHDMSPL-LASKS--GVGLDV------TSFSHQKN-----IASCLKLVDAQVHYFNDNNIRPVGASA-YMELWHSQICD 297
Cdd:PLN02437 231 IYDTLKECaVISKSagGIGLSVhniratGSYIRGTNgtsngIVPMLRVFNDTARYVDQGGGKRKGAFAiYLEPWHADIFE 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 298 FLNakLPEN----PDRCHSLFQGVCIPTLFFRMYEKDpsKLWYLFDPATAPNLIKLYGAAFDNEYERLVRAGKYVSCMPL 373
Cdd:PLN02437 311 FLD--LRKNhgkeEHRARDLFYALWIPDLFMERVQSN--GDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQA 386
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 374 KSMMFTLIHTIIKTGSPYVLLKEALNEHhwTDTQGMA-INCSNLCAEIVQLPG-RNTSVCNLANICLPKCLR-------T 444
Cdd:PLN02437 387 QQLWFAILESQIETGTPYMLFKDSCNRK--SNQQNLGtIKSSNLCTEIIEYTSpTETAVCNLASIALPRFVRekgvpleS 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 445 VESARVGTTDANRPFFCFEALGDAVRVAVLVINACILGGSHPTPGVERGQ-KERSMGIGVQGLADVFAELGYGYLDAESA 523
Cdd:PLN02437 465 HPSKLVGSLGSKNRYFDFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNmRHRPIGIGVQGLADAFILLGMPFDSPEAQ 544
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 524 ELDKNIFQSMYYTAVETSHNL-VLEGqgvPFHGWEVSNFAKGRFHWQTWEGEDASfvpRHRWDALGKSIAEHGIFNSQFL 602
Cdd:PLN02437 545 QLNKDIFETIYYHALKASSELaAREG---PYETYAGSPVSKGILQPDMWGVTPSG---RWDWAALREMISKNGVRNSLLV 618
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 603 AVMPTAGTSQVTGYAESVYPFFANISSKvtnkeEVLRPNVTFFKKVLPDDL------------RVVRQYGG--DVSTFPK 668
Cdd:PLN02437 619 APMPTASTSQILGNNECFEPYTSNIYSR-----RVLSGEFVVVNKHLLHDLtemglwtptlknKIIAENGSvqKIPEIPD 693
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 669 HHRERYRvflTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDrvrNASYLRDLLLHGYRLGLKTLMYYCRvqKQSSLT 748
Cdd:PLN02437 694 DLKAIYK---TVWEIKQRTLVDMAADRGCYIDQSQSLNIHMDQP---NFGKLTSLHFYAWSKGLKTGMYYLR--SRAAAD 765
|
730 740 750 760
....*....|....*....|....*....|....*....|....
gi 139472880 749 ALQCLADPGSPPHSgmkqdgawLPGPKNPEEESCAADPECLVCQ 792
Cdd:PLN02437 766 AIKFTVDTASLKPS--------ATGVAAPEEEDVETKMAQMVCS 801
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
145-740 |
1.97e-72 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 243.99 E-value: 1.97e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 145 QMFMRVSVFVACQCLEHeclywlARDLIEdaksvsemaiveyvfgYLAAQHVCCATPILRSAGVEGGQLASCFILQPsmm 224
Cdd:cd01679 3 DRLMRVALGLASGDLEW------AKEFYD----------------LLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV--- 57
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 225 nePGTLDALYHD-MSPLLASKS--GVGLDVTSF----SHQKNI--AS-----CLKLVDAQVHYFNDNNIRPvGASA-YME 289
Cdd:cd01679 58 --DDSLESIYDTiKECAQLSKIggGIGLNLSNIratgSPIRGTngASngvipFLKLLNDTARYVDQGGQRK-GAGAvYLE 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 290 LWHSQICDFLNAKLPENPD--RCHSLFQGVCIPTLFFRMYEKDpskLWYlfdpatapnliklygaafdneyerlvragky 367
Cdd:cd01679 135 IWHPDIEEFLDLKKNNGDErrRARDLFYGVWIPDLFMERVERD---LWR------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 368 vscmplksmmfTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMaINCSNLCAEIVQ------LPGRNTSVCNLANICLPkc 441
Cdd:cd01679 181 -----------KILESQFETGYPYILFKDTCNRKNPQKHLGT-IKSSNLCTEILQptspseDEPGEDAVCNLASINLG-- 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 442 lRTVEsarvgttdanrpffcFEALGDAVRVAVLVINACILGGSHPTPGVERG-QKERSMGIGVQGLADVFAELGYGYLDA 520
Cdd:cd01679 247 -NFVT---------------FEKLEEVVKLAVRALDNVIDLNYYPVPEAKRSnMRHRAIGLGVMGLHDYLALLRIPYESE 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 521 ESAELDKNIFQSMYYTAVETSHNLVLEgqgvpfhgwevsnfaKGrfhwqtwegedasfvprhrwdalgksiaehGIFNSQ 600
Cdd:cd01679 311 EALDLNDRIFETINYYALKASCELAKE---------------RG------------------------------GLRNSL 345
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 601 FLAVMPTAGTSQVTGYAESVYPFFANISSKVTNKEEVLRPNvtffkKVLPDDLrvvrqyggdvstfpkhhrERYRVFLTA 680
Cdd:cd01679 346 LLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVN-----PHLEKDL------------------WEYGLYKTA 402
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 681 FDYCPFKLLDRARARAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHGYRLGLKTLmYYCR 740
Cdd:cd01679 403 YEIDQRWLIDLAADRQKHIDQGQSLNLFLTPP--ATTRDLNSLYFYAWKKGLKTL-YYLR 459
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
94-747 |
1.55e-45 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 176.68 E-value: 1.55e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 94 NIDALEDMLCAYRrskayedTLNCGYLSAVRLYDTYVLRTMGTEPvyeSVAQMF-MRVSVFVACQCLEHEClYWlardli 172
Cdd:PRK12365 362 DLDALAEALDLSR-------DLQFSYMGVQNLYDRYFNHHEGRRL---ETPQIFwMRVSMGLALNEGQDKT-SW------ 424
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 173 edaksvsemAIVEYvfGYLAAQHVCCATPILRSAGVEGGQLASCFIlqPSMMNEPGTLDALYHDMSPLLASKSGVGLDVT 252
Cdd:PRK12365 425 ---------AITFY--NLLSTFRYTPATPTLFNSGMRHSQLSSCYL--STVQDDLVHIYKVISDNAMLSKWAGGIGNDWT 491
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 253 SFshqKNIASCLKLVDAQVH-------YFNDNNI-------RPVGASAYMELWHSQICDFLNAKLPENPD--RCHSLFQG 316
Cdd:PRK12365 492 AV---RATGALIKGTNGKSQgvipfikVANDTAVavnqggkRKGAVCVYLEVWHLDYEDFLELRKNTGDErrRTHDINTA 568
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 317 VCIPTLFFRMYEKDPSklWYLFDPATAPNLIKLYGAAFD---NEYERLVRAG--KYVSCMPLKSMMFTLIHTIIKTGSPY 391
Cdd:PRK12365 569 SWIPDLFFKRLQQKGT--WTLFSPDDVPGLHEAYGEEFEklyEEYERKVDTGeiRLYKKVEAEDLWRKMLSMLYETGHPW 646
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 392 VLLKEALNEHHWTDTQGMaINCSNLCAEIVQLPGRN-TSVCNLANICLpkclrtVESARVGTTDAnrpffcfEALGDAVR 470
Cdd:PRK12365 647 MTFKDPSNIRSAQDHKGV-VRCSNLCTEILLNCSETeTAVCNLGSINL------VEHIVNDGLDE-------EKLSETIS 712
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 471 VAVLVINACILGGSHPTP-GVERGQKERSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEgQ 549
Cdd:PRK12365 713 IAIRILDNVIDINFYPTKeAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAILASSLLAKE-R 791
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 550 GVpFHGWEVSNFAKGRFHWQTWE------GEDASFVP---RHRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESV 620
Cdd:PRK12365 792 GT-YSSYKGSKWDRGYLPIDTIEllkeyrGEANLLMDtssRKDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGVTQSI 870
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 621 YPFFANISSKVTNKEEVLRPNVTFFKKV---------LPDDLRVVRQYGGDVSTFPKHHReryRVFLTAFDYCPFKLLDR 691
Cdd:PRK12365 871 EPTYKHLFVKSNLSGEFTIPNVYLIEKLkklgiwdadMLDDLKYFDGSLLEIERIPDHLK---KIFLTAFEIEPEWIIEC 947
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*.
gi 139472880 692 ARARAPFVDQSQSMSFFLKEDrvrNASYLRDLLLHGYRLGLKTlMYYCRVQKQSSL 747
Cdd:PRK12365 948 ASRRQKWIDMGQSLNLYLAEP---DGKKLSNMYLTAWKKGLKT-TYYLRSSAATSV 999
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
166-740 |
4.28e-40 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 158.35 E-value: 4.28e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 166 WL--ARDLIEDAKSVSEMAIVEYVFGYLAAQHVCCATPILRSAGVEGGQLASCFI--LQPSmmnepgtLDALYH---DMS 238
Cdd:PRK09209 185 WLtiALYLMQNEPRERRMQLVKEAYWALSNLYMTVATPTLANAGKVGGQLSSCFIdtVDDS-------LQGIYDsntDVA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 239 PLlaSKSGVGLDV---------TSFSHQKNIASCLKLVDAQVhyfndNNI---------RPVGASAYMELWHSQICDFLN 300
Cdd:PRK09209 258 RV--SKHGGGVGAylgkvrsrgSDIRGFKGVSSGVIPWIKQL-----NNTavsvdqlgqRKGAIAVYLDVWHKDIESFLD 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 301 AKLpENPD---RCHSLFQGVCIPTLFFRMYEKDPSklWYLFDPAtapNLIKLYGAAFDNEYERLVRAG----KYVSCM-- 371
Cdd:PRK09209 331 LRL-NNGDerlRAHDVFTGVCIPDLFMEAVERRGD--WYLFDPH---EVKKVMGWYLEDFYDEKKGDGsfreKYEECVad 404
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 372 --------PLKSMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMaINCSNLCAEIVQ--------------------- 422
Cdd:PRK09209 405 erlsrktvKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGM-IYSSNLCTEIMQnmsptvmiqeiisggqivitk 483
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 423 LPGrNTSVCNLANICLpkclrtvesARVGTTDAnrpffcFEALgdaVRVAVLVINACILGGSHPTPGVER-GQKERSMGI 501
Cdd:PRK09209 484 QPG-DFVVCNLSSINL---------GRAVTADV------LERL---IPIQVRMLDNVIDLNQLPVPQATItNQKYRAIGL 544
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 502 GVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEGQGVP-FHGWEvsnfakgrfhWQTWEGEDASFVP 580
Cdd:PRK09209 545 GTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKGAYPvFKGSD----------WQTGEYFERRGYN 614
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 581 RHRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKvtNKEEVLRPNVTffkkvlPDdlrvvrqyg 660
Cdd:PRK09209 615 SPQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDPIYSAFYYE--EKKDYRRPVTA------PD--------- 677
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 661 GDVSTFPKHHRERYRVFLTAFdycpfklLDRARARAPFVDQSQSMSFFLKEDrVRnASYLRDLLLHGYRLGLKTlMYYCR 740
Cdd:PRK09209 678 LSLDTWPYYEKGAYKVDQFWS-------IRQNAARQRHVDQSISFNFYVPST-IR-ASELLDLHMTAWKEGLKT-TYYVR 747
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
112-746 |
1.09e-39 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 157.58 E-value: 1.09e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 112 EDTLNCGYLSAVRLYDTYVLRTMGTEPVyESVAQMFMRVSVFVACQclEHECLYWlardliedAKSVSEMaiveyvfgyL 191
Cdd:PRK08447 132 ERDLQFNYLGIKTLYDRYLIKDRNNNPI-ELPQHMFMAIAMFLAQN--ELDPQKW--------AKKFYDV---------I 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 192 AAQHVCCATPILRSAGVEGGQLASCFIlQPSMMNEPGTLDAlYHDMSPLLASKSGVGLDVT-------SFSHQKNIAS-- 262
Cdd:PRK08447 192 SKFEVMLATPTLSNARTTRHQLSSCYI-GSTPDNIEGIFDS-YKEMALLSKYGGGIGWDWSkvramgsYIDGHKNAAGgi 269
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 263 --CLKLVdaqvhyfNDNNI-------RPVGASAYMELWHSQICDFLNAKLP--ENPDRCHSLFQGVCIPTLFFRMYEKDp 331
Cdd:PRK08447 270 ipFLKIT-------NDIAIavdqlgtRKGAIAVYLEPWHMDISDFIDLRKNsgEERRRAHDLFPALWINDLFMKRVEED- 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 332 sKLWYLFDPATAPNLIKLYGAAFDNEYERLVRAGKYV-SCMPLKSMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMa 410
Cdd:PRK08447 342 -AMWTLFDPYECKDLTELYGEEFEKRYLEYEKDEKIIkEYINAKELWKKILTNYFETGLPFLCFKDNANRANPNAHAGI- 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 411 INCSNLCAEIVQ---------------------------------------------LPGR------------NTSVCNL 433
Cdd:PRK08447 420 IRSSNLCTEIFQntapnhykikiefedgsieffeeeelvtvdsgitkkakkitsldsLKGKkiyivekekkdgKTAVCNL 499
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 434 ANICLPKCLRTVESARVgttdanrpffcfealgdaVRVAVLVINACILGGSHPTPGVERGQ-KERSMGIGVQGLADVFAE 512
Cdd:PRK08447 500 ASINLSKINTKEDIERV------------------VPIAIRMLDNVIDLNFYPNRKVKATNlKSRAIGLGVMGEAQMLAE 561
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 513 LGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEGQGVP-FHGwevSNFAKGRFHWQTWEGEDASFVPR-------HRW 584
Cdd:PRK08447 562 HKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVYPdFEG---SNWSKGIFPIDKANEEAKKLVERgglfdsaCDW 638
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 585 DALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYP------FFANISSkvtnkeevLRPNVTffkkvlpddlrvvrq 658
Cdd:PRK08447 639 EGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPvykrkwFEENLSG--------LIPVVV--------------- 695
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 659 yggdvstfPKHHRERYRVFLTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDRVrNASYLRDLLLHGYRLGLKTlMYY 738
Cdd:PRK08447 696 --------PNLSPETWQYYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLSLDKA-SGKYLNEIYTLAWKLGLKS-TYY 765
|
....*...
gi 139472880 739 CRVQKQSS 746
Cdd:PRK08447 766 LRSESPES 773
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
113-787 |
1.82e-39 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 157.01 E-value: 1.82e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 113 DTLnCGYLSAVRLYDTYVLRTMGTEPVyeSVAQMF-MRVSvfvacqcleheclywLARDLIEDAKSVSEMAIVEYV--FG 189
Cdd:PRK06539 145 DEL-LKYIGVVTLNNRYGIRARNGDAL--EVPQYFwMRIA---------------MGLSLNEDDPTSSALAFYEKMskLE 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 190 YLAAQHVccatpiLRSAGVEGGQLASCFILQpsMMNEPGTLDALYHDMSPLLASKSGVGLDVTSFSHQ------KNIASC 263
Cdd:PRK06539 207 YLAAGST------LVNAGTPYPQLSNCFVME--MQDDIEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQgspirsNNTTST 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 264 LKLvdAQVHYFnDNNIRPV-------GASA-YMELWHSQICDFLNakLPENPD----RCHSLFQGVCIPTLFFRMYEKDP 331
Cdd:PRK06539 279 GPI--PFMHTI-DSVLRAVsrggkkfGALCfYMENWHMDFPEFLD--LRQNSGdpyrRTRTANTAVWISDEFMKRVQNDE 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 332 SklWYLFDPATAPNLIKLYGAAFDNEYERLV---RAGKYVSCMPLKSM-MFTLIHTIIKTGS-PYVLLKEALNEHHWTDT 406
Cdd:PRK06539 354 D--WYLFDPLETPDLNELYGKAFSKRYAQYVeqaEAGRIRMFKRITAReQFRAILMSLQTTShPWLTWKDTINNRALNNN 431
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 407 QGmAINCSNLCAEIVqLPG--RNTSVCNLANICLPKCLRTvesarvGTTDanrpffcFEALGDAVRVAVLVINACILGGS 484
Cdd:PRK06539 432 TG-TIHLSNLCTEIC-LPQdrDNVSVCNLASINLSRHLAD------GELD-------WAQLEESTRLAVRQLDNLIDITA 496
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 485 HPTPGVERG-QKERSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEGQGVP-FHGwevSNFA 562
Cdd:PRK06539 497 SSVKEADFSnQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAIDESADLAAERGAYPnFEG---SRWS 573
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 563 KGRFHWQTWE-GEDASFVP-------RHRWDALGKSIaEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKVTNK 634
Cdd:PRK06539 574 RGMVPVDSIAlLEADRGVPvdvnrttRLDWDALRAKV-RGGMRNATLMAIAPTASIGLVAGTTPGLDPQFSQIFSRSTSS 652
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 635 EEVLRPNVTFFKKV----LPDDLR--VVRQYGG--DVSTFPKHHRERYRvflTAFDYCPFKLLDRArARA-PFVDQSQSM 705
Cdd:PRK06539 653 GKFLEVNRNLVADLkelgLWETVReeILRSQGDiqEIAAIPDEIKALYR---TSFQLSPYAFLEVA-ARAqKWVDQAISR 728
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 706 SFFLKEdrvRNASYLRDLLLHGYRLGLKTlMYYC----RVQKQSSLTALQCLADPGSPPHSGMKQDGAWLPgPKNPEE-- 779
Cdd:PRK06539 729 NMYLES---RDIGDMMDIYTAAWEMGVKT-TYYLhmkpRHTAEQSTVKVNKSAERRGGPRRGFAGFGAGVP-PAVSADli 803
|
730
....*....|
gi 139472880 780 --ESCAADPE 787
Cdd:PRK06539 804 pgASCPVDAQ 813
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
88-740 |
4.44e-39 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 155.68 E-value: 4.44e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 88 ESFIQKNIDALEDMLCAYRrskayEDTLNcgYLSAVRLYDTYVLRTMGTEPVyESVAQMFMRVSVFVACqcleHEclywl 167
Cdd:PRK12364 214 EHYSREEIEEAAGFIDPER-----DKLFT--YSGLDLLLKRYVIRTHSHEPL-ESPQEMFLGIALHLAM----PE----- 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 168 ARDLIEDAKSVSEMaiveyvfgyLAAQHVCCATPILRSAGVEGGQLASCFIlqpsmMNEPGTLDALYHDMSPL-LASKSG 246
Cdd:PRK12364 277 KQDRMGWVKRFYDM---------LSKLKVTMATPTLSNARKPFHQLSSCFI-----DTVPDSLDGIYRSIDNFaQVSKFG 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 247 ------------VGLDVTSFshqKNIAS----CLKLVDAQVHYFNDNNIRPVGASAYMELWHSQICDFLNAKLPENPDR- 309
Cdd:PRK12364 343 ggmglyfgkvraVGSNIRGF---QGVAGgvirWIKLANDTAVAVDQLGMRQGAVAVYLDVWHKDIPEFLQLRTNNGDDRm 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 310 -CHSLFQGVCIPTLFFRMYEKDPSKLWYLFDPAtapNLIKLYGAAFDN----EYERlvragKYVSC----------MPLK 374
Cdd:PRK12364 420 kAHDVFPAVCYPDLFWKMVRDDINQSWYLFCPH---EILTVKGYALEDyygeEWEK-----RYLDCvndariskrsIPIK 491
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 375 SMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQGMaINCSNLCAEIVQ-------------------------LPGrNTS 429
Cdd:PRK12364 492 DLVRLILKSAVETGTPFTFNRDTVNRANPNKHKGM-IYCSNLCTEIAQnmsaietvsteietedgdtvvvtttRPG-DFV 569
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 430 VCNLANICLpkclrtvesarvGTTDANRPffcfEALGDAVRVAVLVINACILGGSHPTPGVE-RGQKERSMGIGVQGLAD 508
Cdd:PRK12364 570 VCNLASLSL------------GNIDLEDE----EELEEVVRTVVRALDNVIDLNFYPVPYAQiTNKRYRSIGLGVSGYHH 633
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 509 VFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEgqgvpfhgwevsnfaKGRFHWqtWEGED----ASFVPR--- 581
Cdd:PRK12364 634 ALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKE---------------KGAYGY--FEGSDwqtgAYFRKRgyt 696
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 582 -HRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYP----FFanisskVTNKEEVLRPNVTffkkvlpddlrvv 656
Cdd:PRK12364 697 sEEWQRLAREVAENGMRNAYLLAVAPTSSTSIIAGTTAGVDPvmkrYF------LEEKKGALMPRVA------------- 757
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 657 rqyggdvstfPKHHRERYRVFLTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHGYRLGLKTLm 736
Cdd:PRK12364 758 ----------PELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITNE--FTMRQVLDLYLLAWEEGVKTI- 824
|
....
gi 139472880 737 YYCR 740
Cdd:PRK12364 825 YYVR 828
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
141-733 |
1.24e-32 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 133.99 E-value: 1.24e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 141 ESVAQMFMRVSvfvacqcleheclYWLARDLIEDAKSVSEMAIVEYvFGYLAAQHVCCATPILR-SAGVEGGQLASCFIL 219
Cdd:TIGR02504 17 ESPEDLFRRVA-------------RALAAAEDKYNSPVWKQWYERF-YDLMVNLGFIPNSPTLMnAGGTRLGQLSACFVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 220 qpSMMNEPGTLDALYHDMSPLLASKSGVGLDvtsFSH---QKNIASC-----------LKLVDAQVHYFNDNNIRPvGAS 285
Cdd:TIGR02504 83 --PVEDSMEDIFEALKEAALIFKRGGGVGYN---FSTlrpKGDLVSGtggvasgpvsfMRVFDSAAGVVKQGGTRR-GAQ 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 286 -AYMELWHSQICDFLNAKLpENPDrchslFQG----VCIPTLFFRMYEKDpsKLWYLFDPATAPnliklygaafdneyER 360
Cdd:TIGR02504 157 mGILDVWHPDIEEFIEAKA-KEGK-----LQNfnisVGVTDEFMEAVEND--EEYELRNPRTGE--------------YK 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 361 LVRAGKyvscmpLKSMMFTLIHtiiKTGSPYVLLKEALNEHHWTDTQGmAINCSNLCAEIVQLPgrNTSvCNLANICLPK 440
Cdd:TIGR02504 215 EVDARE------LWDKIVESAW---KSAEPGVLFIDTINKWHTCPYGG-RINATNPCGEQPLLP--YES-CNLGSINLAK 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 441 CLRTvesarvGTTDanRPFFCFEALGDAVRVAVLVINACILGGSHPTPGVER-GQKERSMGIGVQGLADVFAELGYGYLD 519
Cdd:TIGR02504 282 FVKN------DFGD--EASFDFERLREVVRLATRFLDNVIDINVFPLPEIAEnTKKTRRIGLGIMGLADLLIKLGIPYDS 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 520 AESAELDKNIFQSMYYTAVETSHNLVLEgQGvPFHGWEVSNFAKGRFHWqtweGEDASFVPRHRWDALGKsiaeHGIFNS 599
Cdd:TIGR02504 354 EEARELAEEVMEFIADAAYRASAELAKE-RG-AFPLYDASKYPMGRAMG----ARIPSALPAEIREAIRK----YGIRNA 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 600 QFLAVMPTAGTSQVTGYAESVYPFFA-NISSKVTNKEEVLRPNVTFFK--KVLPDDLRVVRQYGGDVST-----FPKHHR 671
Cdd:TIGR02504 424 QLTTIAPTGTISLIAGTSSGIEPVFAlVYFRNVTVGGELLEVNPLVELalRELGYYSDEIVKYVDEKGTvegapGPEELP 503
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 139472880 672 EryrVFLTAFDYCPFKLLDRARARAPFVDQSQSMSFFLKEDRVR---NASYLRdlllhGYRLGLK 733
Cdd:TIGR02504 504 K---VFVTAMDISPEDHVLMQAAIQPWVDSSISKTINMPSDATVedvKAVYLE-----AWKLGLK 560
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
88-792 |
1.71e-31 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 132.39 E-value: 1.71e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 88 ESFIQKNIDA--LEDMLCAY---RRSKAY--EDTLNCGYLSAVRLYDTYVLRTMGTEpvYESVAQMFMRVSVFVACQCLE 160
Cdd:PRK07207 260 PAFIKKGIEAelLDPKLAQFdleRLGAALdpERDLQFTYLGLQTLYDRYFLHVDGTR--IELPQAFFMRVAMGLALNEID 337
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 161 HEclywlARdliedaksvsemAIVEY----VFGYLaaqhvcCATPILRSAGVEGGQLASCFilqpsMMNEPGTLDALYHD 236
Cdd:PRK07207 338 RE-----AR------------AIEFYnllsSFDFM------SSTPTLFNSGTLRPQLSSCY-----LTTVPDDLDGIYEA 389
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 237 M--SPLLaSK--SGVGLDVTSF----SHQK--NIAS-----CLKLVDAQVHYFNDNNIRPVGASAYMELWHSQICDFLna 301
Cdd:PRK07207 390 IkdNALL-SKfaGGLGNDWTPVralgSHIKgtNGKSqgvvpFLKVVNDTAVAVNQGGKRKGAVCAYLETWHLDIEEFL-- 466
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 302 KLPENP-D---RCHSLFQGVCIPTLFF-RMYEKDPsklWYLFDPATAPNLIKLYGAAFD---NEYERLVRAG-----KYV 368
Cdd:PRK07207 467 ELRKNTgDdrrRTHDMNTANWIPDLFMkRVMEDGE---WTLFSPSEVPDLHDLFGKAFEeayTAYEAKAARGeiklfKKI 543
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 369 SCMPL--K--SMMFtlihtiiKTGSPYVLLKEALN----EHHwtdtQGMaINCSNLCAEIVQlpgrNTS-----VCNLAN 435
Cdd:PRK07207 544 PAVDLwrKmlSMLF-------ETGHPWITFKDPCNlrspQQH----VGV-VHSSNLCTEITL----NTSddeiaVCNLGS 607
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 436 ICLPKCLrtVESARVGTtdanrpffcfEALGDAVRVAVLVINACILGGSHPTPGVERGQ-KERSMGIGVQGLADVFAELG 514
Cdd:PRK07207 608 VNLVAHI--KDGAKLDH----------EKLKRTVSTAMRMLDNVIDINYYAVPKARNSNlRHRPVGLGIMGFQDALYLLR 675
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 515 YGYLDAESAEldkniF--QSM----YYtAVETSHNLVLE-GQGVPFHG--WE--------VSNFAKGRfhwqtweGE--- 574
Cdd:PRK07207 676 IPYASDEAVE-----FadRSMeavsYY-AIWASTELAEErGRYSSYEGslWSrgilpidsLKLLAEAR-------GGyle 742
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 575 -DASFvpRHRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSK--------VTNK----------- 634
Cdd:PRK07207 743 vDRSS--TLDWDALRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPTYQNLYVKsnlsgeftVVNPylvrdlkargl 820
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 635 -EEVLRPNVTFFKKVL------PDDLRvvrqyggdvstfpkhhreryRVFLTAFDYCPFKLLDRARARAPFVDQSQSMSF 707
Cdd:PRK07207 821 wDEVMVNDLKYFDGSLqridriPADLK--------------------ALYATAFEVDPRWLVEAASRRQKWIDQAQSLNL 880
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 708 FLKEdrvrnAS--YLRDLLLHGYRLGLKTlMYYCR------VQKqSSLTALQCLADPGSPPHSGMKQDGAwlPGPKNPEE 779
Cdd:PRK07207 881 YMAG-----ASgkKLDETYKLAWLRGLKT-TYYLRtlgathVEK-STVNTGALNAVSSGGGGAGGAAAAA--AAPPAADP 951
|
810
....*....|....
gi 139472880 780 ESCA-ADPECLVCQ 792
Cdd:PRK07207 952 KACSiDDPDCEACQ 965
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
125-752 |
3.50e-31 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 130.70 E-value: 3.50e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 125 LYDTYVLRTMGTEPVyESVAQMFMRVSVFVACQCLEHECLYWLAR--DLIEDAKsvsemaiveyvfgylaaqhVCCATPI 202
Cdd:PRK07088 166 LADRYLVKGFNREIL-ELPQERFMGIAMHLAIPEGKEKRVYYAKKfyDLLSELK-------------------ATVATPT 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 203 LRSAGVEGGQLASCFIlqpSMMNEpgTLDALYHDMSPLL-ASKSGVGLDV---------TSFSHQKNIASClklVDAQVH 272
Cdd:PRK07088 226 LSNAGTPFYQLSSCFI---SVVDD--NLWSIYDVNQKFAqVSKHGGALGIytgkiralnSEIRGFKNASGG---VIPWIK 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 273 YFNDNNI-------RPVGASAYMELWHSQICDFLNAKLPENPDR--CHSLFQGVCIPTLFFRMYEKDPSklWYLFDPATA 343
Cdd:PRK07088 298 LYNDTAIavdqlgkRKGGAAITLDIWHKDIPEFLDLKTNNGDDRrkAHDIFPGVSYPDLFMKRLEKREN--WSLFDPHEI 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 344 PN-----LIKLYGAAFDNEYERlvragKYVSC----------MPLKSMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQG 408
Cdd:PRK07088 376 KKvkgysLEDYYDEEDRKEFTK-----KYLECeedtniprrtVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKG 450
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 409 MaINCSNLCAEIVQ-------------------------LPGrNTSVCNLANICLPKCLRtvesarvgttdanrpffcfE 463
Cdd:PRK07088 451 M-IYSSNLCHEIAQnmseselleeeiidengyyevvqkiKAG-DMVTCNLNSIVLGNVDD-------------------E 509
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 464 ALGDAVRVAVLVINACILGGSHPTPGVE-RGQKERSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSH 542
Cdd:PRK07088 510 ELEEVIPTQIRMLDNVISLNYYPVPEAEiTSDKYRAIGLGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASM 589
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 543 NLVLEGQGVP-FHG--WEVSNFAKGRFHwqtwegedasfvPRHRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAES 619
Cdd:PRK07088 590 ELAKEKGSYPaFKGseWETGKYFERRGY------------NSERWKKLKEEIKKYGMRNGYITAVAPTGSTSNIANTTAG 657
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 620 VYPFFANisskvtnkeevlrpnvtFF---KK--VLPddlrvvrqyggdvSTFPKHHRERYRVFLTAFDYCPFKLLDRARA 694
Cdd:PRK07088 658 IDPVFKR-----------------FFmeeKKgsFTP-------------KTAPDLNEENFWYYKEAHTIDQQWSIKACGV 707
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*...
gi 139472880 695 RAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHGYRLGLKTLmYYCRVQkqsSLTALQC 752
Cdd:PRK07088 708 RQRHIDQAQSFNLYITPE--YKAKQILNLYIEAWKQGVKTI-YYVRNK---SLEMDEC 759
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
188-625 |
8.31e-30 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 123.88 E-value: 8.31e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 188 FGYLAAQHVCCATPILRSAGV-EGGQLASCFILQPSMMNEPGTLDALyHDMSPLLASKSGVGldvTSFSH---QKNIA-- 261
Cdd:cd02888 5 FYLLLSQGFIPNSPTLMNAGTgELGQLSACFVLPVEDDSIEGIFDAL-KEAALIFKRGGGVG---YNFSRlrpKGDIVks 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 262 ---------SCLKLVDAQVHYFNDNNIRPvGA-SAYMELWHSQICDFLNAKLPENPDRCHSLFQ-GVCIPTLFFRMYEKD 330
Cdd:cd02888 81 tggvasgpvSFMRVFDAATGVIKQGGTRR-GAnMGVLDVDHPDIEEFIDAKMKEEKTVVLQNFNiSVAVTDAFMEAVEND 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 331 -PSKLWYLFDPATApnliklygaafdnEYERLVRAGKyvscmplksmMFTLI-HTIIKTGSPYVLLKEALNEHHWTDTQG 408
Cdd:cd02888 160 ePWELRNPREPDTG-------------KVYRTVPARE----------LWDKIvEAAWDSADPGVLFIDTINRWNPLPGLG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 409 mAINCSNLCAEIVQLPgrnTSVCNLANICLPKCLRtvesarVGTTDANrpfFCFEALGDAVRVAVLVINACILGGSHPTP 488
Cdd:cd02888 217 -RINATNPCGEQPLLP---YESCNLGSINLSKFVK------NPFGGAS---FDFERLREAVRLAVRFLDNVIDVNRYPLP 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 489 GVER-GQKERSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEgQGvPFHGWEVSNFAKGRFH 567
Cdd:cd02888 284 EIAEeTKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKE-RG-PFPLFDASRYLMLKVI 361
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 139472880 568 WQTwegedasfvpRHRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFA 625
Cdd:cd02888 362 VNA----------KELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPIFS 409
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
199-792 |
1.18e-23 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 106.20 E-value: 1.18e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 199 ATPILRSAGVEGGQLASCFilqpsmMNE-PGTLDALYHDMSPL--LASKSG-----------VGLDVTSFSHQKNIASCL 264
Cdd:PRK09102 74 ATPVLSNGGTDRGLPISCF------LNYvEDSLEGIVNTWNENvwLAKRGGgigsywgnvrsIGEPIRNNGKSSGIIPFI 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 265 KLVDAQVHYFNDNNIRPVGASAYMELWHSQICDFLNAKLP-ENPDR-CHSLFQGVCIPTLFFRMYEKDPSklWYLFDPAt 342
Cdd:PRK09102 148 KVMDSLTLAISQGSLRRGSFAVYLDIEHPEIEEFLDIRKPtGDPNRkALNLHHGVCVTDEFMEAVEDGDE--WDLISPK- 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 343 apnliklygaafDNEYERLVRAgkyvscmplKSMMFTLIHTIIKTGSPYVLLKEALNEH---HWTDtQGMAINCSNLCAE 419
Cdd:PRK09102 225 ------------DKSVIRTVKA---------RDLWAKILETRIETGEPYLLFIDNVNRAlpeVYKD-LGLKVKASNLCSE 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 420 IVqLP-GRN------TSVCNLANICLPKCL------RTVESArVGTTDANRPFFCFEA---LGDAVRVAVlvinacilgg 483
Cdd:PRK09102 283 IT-LPtGIDhlgedrTAVCCLSSLNLEYYDewkdtdAFIEDL-MRFLDNVLQDFIDKApdeMERAKYSAM---------- 350
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 484 shptpgvergqKERSMGIGVQGLadvfaelgYGYLDA-----ESAE---LDKNIFQSMYYTAVETSHNLVLEgqgvpfhg 555
Cdd:PRK09102 351 -----------RERSVGLGVMGF--------HSYLQSkmipfESVMakqWNKKIFKHIREQADKASKELAKE-------- 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 556 wevsnfaKGrfhwqtwEGEDAsfvprhrwdalgksiAEHGIF--NSQFLAVMPTAGTSQVTGYAE-SVYPFFANISSKVT 632
Cdd:PRK09102 404 -------KG-------ECPDA---------------AGYGVMrrFSTKMAIAPTASISIILGNTSpGIEPIAANYYTHKT 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 633 NKEEVLRPNvTFFKKVL-------PDDLRVVRQYGGDVSTFPKHHRERYRVFLTAFDYCPFKLLDRARARAPFVDQSQSM 705
Cdd:PRK09102 455 LKGSFTVKN-KYLEKLLeekgkdtDEVWSSILTNEGSVQHLDFLSEEEKDVFKTAFEIDQRWIIELAADRQKYIDQAQSL 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 706 SFFLKEDrvRNASYLRDLLLHGYRLGLKTLmYYCRvqkqsSLTALQclADPGSppHSGMKQDGAWLPGPKNPEEescaad 785
Cdd:PRK09102 534 NLFLPAN--VPKRDLNKLHFEAWKKGVKSL-YYQR-----SKSVQR--ADKVS--HDVLKKRLVEKSAFNRDYD------ 595
|
....*..
gi 139472880 786 pECLVCQ 792
Cdd:PRK09102 596 -ECLACQ 601
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
119-737 |
1.18e-21 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 100.56 E-value: 1.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 119 YLSAVRLYDTYVLRTMGTEPVYESVAQMFMRVSVfvacqcleheCLYwlardliEDAKSVSEMAIVEYVFGYLAAQHVCC 198
Cdd:PHA02572 143 YAGAMQLKEKYLVQDRSTGEIYETPQFAYMLIAM----------ALH-------QDEPKEDRLEHVIRFYNAVSTRKISL 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 199 ATPILrsAGVEGG--QLASCFILqpsmmnEPG-TLDALYH-DMS--PLLASKSGVGLDVtsfSHQKNIAS---------- 262
Cdd:PHA02572 206 PTPIM--AGVRTPtrQFSSCVVI------ESGdSLDSINKtAMAivKYISKRAGIGINA---GMIRAEGSkirggevrht 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 263 ----CLKLVDAQVHYFNDNNIRPVGASAYMELWHSQICDFL---NAKLPENpDRCHSLFQGVCIPTLFF-RMYEKDPSkl 334
Cdd:PHA02572 275 gvipFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLvlkNNKGVEE-NRIRHLDYGVQINDLMYeRFIKNDYI-- 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 335 wYLFDPATAPNLikLYGAAFDN--EYERLVRAGKYVSCMPLKSMMFT-LIHTIIK----TGSPYVLLKEALNEHH-WTDT 406
Cdd:PHA02572 352 -TLFSPHDVGGE--LYDAYFADqdRFRELYEALEKDPSVRKKRIKAQeLFLLLLKerseTGRIYIMFIDHCNNHSpFKDP 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 407 qgmaINCSNLCAEIVqLPGR---------NTSVCNLANICLPKcLRTVESarvgttdanrpffcFEALGDavrVAVLVIN 477
Cdd:PHA02572 429 ----IRQSNLCCEIA-LPTKplnhidgegEIALCTLSAIVLGN-FEDQDE--------------IEELAE---VAVRALD 485
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 478 ACILGGSHPTPGVERGQKERSMGIGVQGLADVFAELGYGYLDAEsAELDKNIFQSMYYTAVETSHNLVLE-GQGVPFHGw 556
Cdd:PHA02572 486 NLLDYQDYPVPAALKAKKRRSLGVGVTNYAHYLAKNFASYEDAN-ADLVHELFERLQYYLIKASNKLAKEkGACEYFSD- 563
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 557 evSNFAKGRFHWQTWEGEDASFVP---RHRWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKvTN 633
Cdd:PHA02572 564 --TKYSRGELPIDWYKKKVDELVApkyNCDWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRGPVSIK-KS 640
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 634 KEEVlrpnvtfFKKVLPD--DLRVVRQYGGDVStfpKHHRERYrvfltafdycpfklLDRARARAPFVDQSQSMSFF--- 708
Cdd:PHA02572 641 KEGP-------FNQVVPNveTLKDLYDLLWDLA---KKGNKGY--------------LTQVAIMQKFVDQAISANTSydp 696
|
650 660 670
....*....|....*....|....*....|.
gi 139472880 709 --LKEDRVRNASYLRDlLLHGYRLGLKTLMY 737
Cdd:PHA02572 697 enYPNGKVPMSVMLDD-LLYFYYYGGKTLYY 726
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
117-209 |
1.05e-14 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 69.57 E-value: 1.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 117 CGYLSAVRLYDTYVLRTMGTEpVYESVAQMFMRVSVFVACQCLEHEclywlardliedaksvsEMAIVEYVFGYLAAQHV 196
Cdd:pfam00317 1 LTYLGAKVLEDRYLLKDEDGE-LLETPQDMFMRVALALAGAELEED-----------------RLELAEEFYDLLSSLKF 62
|
90
....*....|...
gi 139472880 197 CCATPILRSAGVE 209
Cdd:pfam00317 63 LPATPTLMNAGTP 75
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
284-737 |
8.66e-12 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 68.86 E-value: 8.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 284 ASAYMELWHSQICDFL----NAKLPENpdRCHSLFQGVCIPTLffrMYEK-----DPSklwyLFDPATAPNLiklYGAAF 354
Cdd:PRK09103 299 ATLFYPIWHLEVESLLvlknNRGVEEN--RVRHMDYGVQINKL---MYQRlikggDIT----LFSPSDVPGL---YDAFF 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 355 DN--EYERL---------VRAgKYVSCMPLKSMMftlIHTIIKTGSPYVLLKEALNEHHWTDTQGMAINCSNLCAEIVqL 423
Cdd:PRK09103 367 ADqdEFERLytkyeqddsIRK-KRVKAVELFSLM---MQERASTGRIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIA-L 441
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 424 PGRNtsvcnLANICLPK---CLRTVESARVGTtdanrpffcFEALGDAVRVAVLVINA--CILG-GSHPTPGVERGQK-E 496
Cdd:PRK09103 442 PTKP-----LNDVNDENgeiALCTLSAFNLGA---------INSLDELEELADLAVRAldALLDyQDYPIPAAKRGAMgR 507
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 497 RSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEGQGVP-FHGwevSNFAKGRFHWQTWEGED 575
Cdd:PRK09103 508 RTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQGACPwFNE---TTYAQGILPIDTYKKDL 584
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 576 ASFV--PRH-RWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKVTnKEEVLrpnvtffKKVLPDD 652
Cdd:PRK09103 585 DAICnePLHyDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKAS-KDGIL-------KQVVPDY 656
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 653 LRVVRQY-------GGD-----VSTFPKhhreryrvfltafdycpfklldrararapFVDQSQSM------SFFlKEDRV 714
Cdd:PRK09103 657 ERLKDAYellwempNNDgylqlVGIMQK-----------------------------FVDQSISAntnydpSRF-PSGKV 706
|
490 500
....*....|....*....|...
gi 139472880 715 RNASYLRDLLLhGYRLGLKTLMY 737
Cdd:PRK09103 707 PMKQLLKDLLT-AYKFGVKTLYY 728
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
200-644 |
1.63e-11 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 67.95 E-value: 1.63e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 200 TPILRSAGVEGGQLASCFILqPSMMNEPGTLDALYHDMsplLASKSGVGldvTSFSHQ------------KNIAS----C 263
Cdd:PRK06406 236 SPTLMNAGTKLGQLSACFVL-PVPDSIEGIFNALKYTA---MIHKSGGG---TGFSFSrlrpkddivastKGVASgplsF 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 264 LKLVDAQVHYFNDNNIRPVGASAYMELWHSQICDFLNAKLPENpdRCHSLFQ-GVCIPTLFFRMYEKDpsklwylfdpat 342
Cdd:PRK06406 309 MRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSKDSEN--KVLSNFNiSVAVTDEFFDKLDND------------ 374
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 343 apnliklygaafdnEYERLV--RAGKYVSCMPLKSMMFTLIHTIIKTGSPYVLLKEALNEHHWTDTQGmAINCSNLCAEI 420
Cdd:PRK06406 375 --------------DYYPLRnpRNGKEVKRIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKNLG-EIESTNPCGEQ 439
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 421 VQLPGRNtsvCNLANICLPKclrTVESARVGttdanrpffcFEALGDAVRVAVLVINACILGGSHPTPGVER-GQKERSM 499
Cdd:PRK06406 440 PLLPYES---CNLGSINLSK---FVENGKID----------WDRLRETVHIATRFLDNVIDANKFPVPQIKEmTRMTRKI 503
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 500 GIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVlEGQGVpFHGWEVSNfakgrfhwqtWEGEDASfv 579
Cdd:PRK06406 504 GLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLA-EERGV-FPAWYGSE----------WEKKGIK-- 569
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 139472880 580 prhrwdalgksiaehgIFNSQFLAVMPTAGTSQVTGYAESVYPFFA-NISSKVTNKEEVLRPNVTF 644
Cdd:PRK06406 570 ----------------MRNSTTTTIAPTGTISIIAGCSSSIEPLFAiAFVRHVLNGQELLEVNPLF 619
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
408-625 |
2.08e-10 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 64.48 E-value: 2.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 408 GMAINCSNLCAEIVQLPgrnTSVCNLANICLPKclrtVESARVGTTDanrpffcFEALGDAVRVAVL----VINAcilgg 483
Cdd:PRK08115 470 GQKVVATNPCGEQPLAP---YSVCNLAAINLAN----MADKETKTVD-------YEKLKRTVEVGVRmqdnVIDA----- 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 484 shpTP-----GVERGQKERSMGIGVQGLAD--VFAELGYGylDAESAELDKNIFQSMYYTAVETSHNLVLEGQGVPF--- 553
Cdd:PRK08115 531 ---TPyfleeNKKQALGERRVGLGVMGLHDllIYCETVYG--SEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPFlvg 605
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 139472880 554 HGWEVSNFAKGRFhwqtwegEDASFVPRHRWDALgKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFA 625
Cdd:PRK08115 606 QTEEETAKLREAF-------INTGYMKKMPEDIR-EDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPYFS 669
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
400-682 |
1.11e-09 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 62.48 E-value: 1.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 400 EHHWTDTQG-MAINCSnlcaeivQLPGRNTSVCNLANICLPKCLRTVESARvgttdanrPFFCFEALGDAVRVAVLVINA 478
Cdd:PRK08332 1283 EHHSYISNGfMSHNCG-------EEPLYEYESCNLASINLAKFVKYDENGK--------PYFDWDEYAYVIQKVAKYLDN 1347
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 479 CILGGSHPTPGVERGQK-ERSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYYTAVETSHNLVLEgQGvPFHGWE 557
Cdd:PRK08332 1348 AIDVNKFPLPEIDYNTKlTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKK-RG-TFPLYE 1425
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 558 VSNFAKGR------FHWQTWEgedasfVPrhrWDALGKSIAEHGIFNSQFLAVMPTAGTSQVTGYAESVYPFFANISSKV 631
Cdd:PRK08332 1426 KTEYPKGElpvegfYHPEIWN------LP---WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKS 1496
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 139472880 632 TNKEEVLRPNVTF----FKKVLPDD--LRVVRQYGGDVSTFPKHHRERYRVFLTAFD 682
Cdd:PRK08332 1497 VTVGEFYYVDPVFeaelKKRGLYSEelLKKISDNYGSVQGLEEIPEDMQRVFVTALD 1553
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
457-733 |
8.43e-09 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 59.04 E-value: 8.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 457 RPFFCFEALGDAVRVAVLVINACILGGSHPTPGVER-GQKERSMGIGVQGLADVFAELGYGYLDAESAELDKNIFQSMYY 535
Cdd:PRK06948 322 EPRFDFAALATAVRIQVRMLDNALDLTRWPLAAHAReARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRH 401
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 536 TAVETSHNLVLEGQGVPFHGWEVSnFAKGRFhwqtwegedASFVPRhrwdALGKSIAEHGIFNSQFLAVMPTAGTSqvtg 615
Cdd:PRK06948 402 HAYAASAALAAERGAYPLCDPAAH-LDALRA---------GPPLPH----AVCHAIARHGLRNSHLLSFAPVGSVS---- 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 139472880 616 yaesvYPFFANISSKVtnkeevlRPNVTFFKKvlpddlRVVRQYGGDVST----------FPKHHRERYRV---FLTAFD 682
Cdd:PRK06948 464 -----LAFGDNCSPGI-------EPARAWIEH------RPVRAGAGGARGmraenhayrlFRSLRGERAALpdyFVTAAD 525
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 139472880 683 YCPFKLLDRARARAPFVDQSQSMSFFLKEDrvRNASYLRDLLLHGYRLGLK 733
Cdd:PRK06948 526 VAPADHLAMRAALQPYVDAGISKTVTLPNH--YSLAEVDALLFQAWRAGLK 574
|
|
| |
