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Conserved domains on  [gi|195661126|ref|YP_002117878|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Ursus spelaeus]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 7.96e-96

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 274.76  E-value: 7.96e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   1 MMMYIVFILSTIFVMGFVGFSSKPSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126  81 EVWVSNKAVLGAFIVGLLSELLIACYVLKDDEVEIVFKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 195661126 161 LLIGVLVIMEVTRGN 175
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 7.96e-96

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 274.76  E-value: 7.96e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   1 MMMYIVFILSTIFVMGFVGFSSKPSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126  81 EVWVSNKAVLGAFIVGLLSELLIACYVLKDDEVEIVFKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 195661126 161 LLIGVLVIMEVTRGN 175
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-170 2.14e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 58.28  E-value: 2.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   18 VGFSSKPSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYPEVWVSNKAVLGAFIVGL 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195661126   98 LseLLiacyvlkddeVEIVFKFNGMGDWVIYDTGDSGFFSEEAMGIaALYSYGTWLVIVTGWSLLIGVLVIME 170
Cdd:pfam00499  81 L--LL----------ALLLLVLLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIV 140
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-175 7.96e-96

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 274.76  E-value: 7.96e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   1 MMMYIVFILSTIFVMGFVGFSSKPSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126  81 EVWVSNKAVLGAFIVGLLSELLIACYVLKDDEVEIVFKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWS 160

                        170
                 ....*....|....*
gi 195661126 161 LLIGVLVIMEVTRGN 175
Cdd:MTH00109 161 LFIGVFVIIEITRGN 175
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 2-174 7.33e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 114.85  E-value: 7.33e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   2 MMYIVFILSTIFVMGFVGFSSKPSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126  82 VWVSNkAVLGAFIVGLLSELLIACYVLKDdeveivfkfNGMGDWVI-YDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWS 160
Cdd:MTH00138  81 SWGSW-SVLGYVVGYLVGVVLAAGLFWGG---------WYEGSWVVvDELKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                        170
                 ....*....|....
gi 195661126 161 LLIGVLVIMEVTRG 174
Cdd:MTH00138 151 LLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 2-174 4.88e-30

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 107.63  E-value: 4.88e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   2 MMYIVFILSTIFVMGFVGFSSKPSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126  82 VWvSNKAVLGAFIVGLLseLLIACYVLKDDEVEIVFKFNGMGDWViydtgdsGFFSEEAMGIAALYSYGTWLVIVTGWSL 161
Cdd:MTH00065  81 AW-GSWSVLVYVLFYLL--LLIVGYILFGCNFSLEFLFTNYDTEF-------SVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|...
gi 195661126 162 LIGVLVIMEVTRG 174
Cdd:MTH00065 151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 2-174 2.74e-24

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 92.89  E-value: 2.74e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   2 MMYIVFILSTIFVMGFVGFSSKPSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126  82 VWVSNKAVlgAFIVGLLSELLIACYVLkddeveIVFKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSL 161
Cdd:MTH00115  81 AWGDWGVV--GYVVGFVLVVVVVGVVV------GGLWGMEGVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|...
gi 195661126 162 LIGVLVIMEVTRG 174
Cdd:MTH00115 153 LLTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 2-174 1.32e-16

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 72.71  E-value: 1.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   2 MMYIVFILSTIFVMGFVGFSSKPSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126  82 VWVSNKAVLGAFIVGLLselliacyvlkddeVEIVFKFNGMGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGWSL 161
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLG--------------LGFVGFYFYGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|...
gi 195661126 162 LIGVLVIMEVTRG 174
Cdd:MTH00214 147 FLVLFVVLELVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 2-175 3.97e-12

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 60.69  E-value: 3.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   2 MMYIVFILSTIFVMGFVGFSSkpSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYPe 81
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126  82 vwvsnkavlgafIVGLLSELLIACYVLKddeVEIVFKFNGMGDWVIYDTGDSGFFSEeaMGIAALYSYGTWLVIVTGWSL 161
Cdd:MTH00045  78 ------------SVSNLGEVLVLSLLLS---LWVFISFDNFLELSNNNWSLVSLSDL--VGSSELYNSGGLYLLLGGFIL 140

                        170
                 ....*....|....
gi 195661126 162 LIGVLVIMEVTRGN 175
Cdd:MTH00045 141 LVALVVALVISFGH 154
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-170 2.14e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 58.28  E-value: 2.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   18 VGFSSKPSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMATEQYPEVWVSNKAVLGAFIVGL 97
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195661126   98 LseLLiacyvlkddeVEIVFKFNGMGDWVIYDTGDSGFFSEEAMGIaALYSYGTWLVIVTGWSLLIGVLVIME 170
Cdd:pfam00499  81 L--LL----------ALLLLVLLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIV 140
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 1-75 9.88e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 40.64  E-value: 9.88e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195661126   1 MMMYIVFILSTIFVMGFVGFSSkpsPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMA 75
Cdd:MTH00152   1 MSLMILLSVCFSLFLLLPLSKQ---PLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 2-103 9.41e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 38.06  E-value: 9.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661126   2 MMYIVFILSTIFVMgfvgFSSKPSPIYGGLVLIISGGVGCGIVLNFGGSFLGLMVFLVYLGGMLVVFGYTTAMAteqyPE 81
Cdd:MTH00212   3 LSLLLSLLLLLMLL----FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALS----PN 74

                         90       100
                 ....*....|....*....|..
gi 195661126  82 VWVSNKAVLGAFIVGLLSELLI 103
Cdd:MTH00212  75 EHLFFKKYFKGFGMILISLNLY 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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