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Conserved domains on  [gi|195661263|ref|YP_002117926|]
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NADH dehydrogenase subunit 3 (mitochondrion) [Arctodus simus]

Protein Classification

NADH dehydrogenase subunit 3( domain architecture ID 10009567)

NADH dehydrogenase subunit 3 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that couples the transfer of electrons from NADH to quinone with the translocation of protons across the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND3 MTH00106
NADH dehydrogenase subunit 3; Provisional
 1-115 6.31e-55

NADH dehydrogenase subunit 3; Provisional


:

Pssm-ID: 177168 [Multi-domain]  Cd Length: 115  Bit Score: 166.65  E-value: 6.31e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFTNTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00106   1 MNLMLTLLTNTLLASLLVLIAFWLPQLNIYSEKASPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQ 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 195661263  81 AKNPTTVLITALLLISLLAASLAYEWTEKGLDWTE 115
Cdd:MTH00106  81 TNNLNTMLTMALLLISLLALSLAYEWTQKGLEWTE 115
 
Name Accession Description Interval E-value
ND3 MTH00106
NADH dehydrogenase subunit 3; Provisional
 1-115 6.31e-55

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177168 [Multi-domain]  Cd Length: 115  Bit Score: 166.65  E-value: 6.31e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFTNTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00106   1 MNLMLTLLTNTLLASLLVLIAFWLPQLNIYSEKASPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQ 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 195661263  81 AKNPTTVLITALLLISLLAASLAYEWTEKGLDWTE 115
Cdd:MTH00106  81 TNNLNTMLTMALLLISLLALSLAYEWTQKGLEWTE 115
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
18-69 5.07e-21

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 80.16  E-value: 5.07e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 195661263   18 VLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEI 69
Cdd:pfam00507   1 LLLSRLLGPKRPNPEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVEV 52
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 3-69 3.15e-15

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 65.91  E-value: 3.15e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195661263   3 LILALFTnTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEI 69
Cdd:COG0838    9 LIFLLVA-LGLALAMLLLSRLLGPKRPNPEKLSPYECGIEPVGDARIRFSVRYYLVALLFVIFDVEV 74
 
Name Accession Description Interval E-value
ND3 MTH00106
NADH dehydrogenase subunit 3; Provisional
 1-115 6.31e-55

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177168 [Multi-domain]  Cd Length: 115  Bit Score: 166.65  E-value: 6.31e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFTNTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00106   1 MNLMLTLLTNTLLASLLVLIAFWLPQLNIYSEKASPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWASQ 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 195661263  81 AKNPTTVLITALLLISLLAASLAYEWTEKGLDWTE 115
Cdd:MTH00106  81 TNNLNTMLTMALLLISLLALSLAYEWTQKGLEWTE 115
ND3 MTH00136
NADH dehydrogenase subunit 3; Provisional
 1-115 1.57e-36

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177194 [Multi-domain]  Cd Length: 116  Bit Score: 120.02  E-value: 1.57e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFT-NTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAL 79
Cdd:MTH00136   1 MNLITTILTiTIALSLILAIVSFWLPQMTPDHEKLSPYECGFDPLGSARLPFSLRFFLVAILFLLFDLEIALLLPLPWGD 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 195661263  80 QAKNPTTVLITALLLISLLAASLAYEWTEKGLDWTE 115
Cdd:MTH00136  81 QLPSPLLTFFWATAVLILLTLGLIYEWLQGGLEWAE 116
ND3 MTH00069
NADH dehydrogenase subunit 3; Provisional
 3-115 1.95e-34

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177141 [Multi-domain]  Cd Length: 114  Bit Score: 114.71  E-value: 1.95e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   3 LILALFTNTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWALQAK 82
Cdd:MTH00069   2 IMLMLLISTILSLILITISFWLPLNNPDSEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPTPWASQLN 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 195661263  83 NPTTVLITALLLISLLAASLAYEWTEKGLDWTE 115
Cdd:MTH00069  82 TPTNTLFWSTLILILLTLGLIYEWIQGGLEWAE 114
ND3 MTH00113
NADH dehydrogenase subunit 3; Provisional
 1-114 3.13e-31

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177175 [Multi-domain]  Cd Length: 114  Bit Score: 106.50  E-value: 3.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFTNTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00113   1 MNLISMLTISLALSTILTTLNFWLTQTKPDNEKLSPYECGFDPLGSARLPFSIRFFLVAILFLLFDLEIALLLPLPWAIN 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 195661263  81 AKNPTTVLITALLLISLLAASLAYEWTEKGLDWT 114
Cdd:MTH00113  81 LTTPTTTLTWATIILTLLTLGLIYEWLQGGLEWA 114
ND3 MTH00042
NADH dehydrogenase subunit 3; Validated
 1-115 1.86e-29

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 177117 [Multi-domain]  Cd Length: 116  Bit Score: 102.37  E-value: 1.86e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFTNTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00042   2 TNLIFFLLIILILTSLLLLAGHFLPSRSPDLEKSSPYECGFDPLNSARLPFSFRFFLVAILFLLFDLEIALLFPLPPATL 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 195661263  81 AKNPTTVLITALLLISLLAASLAYEWTEKGLDWTE 115
Cdd:MTH00042  82 ITNPSTLLPISLIFLIILTIGLVYEWVNGGLEWAE 116
ND3 MTH00203
NADH dehydrogenase subunit 3; Provisional
 1-113 7.89e-25

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214456 [Multi-domain]  Cd Length: 112  Bit Score: 90.34  E-value: 7.89e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFT-NTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWAL 79
Cdd:MTH00203   1 MNLIMLFFLiALLLSLILLFIAFWLPKVNPDGEKLSPYECGFDPLGSARLPFSLQFFLVALSFLLFDLEIALLLPLPWSN 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 195661263  80 QAKNPTTVliTALLLISLLAASLAYEWTEKGLDW 113
Cdd:MTH00203  81 QLSSLSLL--LAFLFLILLTLGLIYEWLQGGLEW 112
Oxidored_q4 pfam00507
NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;
18-69 5.07e-21

NADH-ubiquinone/plastoquinone oxidoreductase, chain 3;


Pssm-ID: 459838 [Multi-domain]  Cd Length: 94  Bit Score: 80.16  E-value: 5.07e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 195661263   18 VLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEI 69
Cdd:pfam00507   1 LLLSRLLGPKRPNPEKLSPYECGFDPVGDARLRFSVRFYLVAILFLIFDVEV 52
ND3 MTH00148
NADH dehydrogenase subunit 3; Provisional
 1-69 2.51e-20

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214433 [Multi-domain]  Cd Length: 117  Bit Score: 79.13  E-value: 2.51e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFTNTLLASLLVLIAFWLPQLNIYA-EKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEI 69
Cdd:MTH00148   2 LSILLSLLFALILSPVLLLLGLVLSKRSYSDrEKSSPFECGFDPISSARSPFSLRFFLLAILFLVFDVEI 71
ND3 MTH00012
NADH dehydrogenase subunit 3; Validated
 1-114 7.82e-18

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164588 [Multi-domain]  Cd Length: 117  Bit Score: 72.58  E-value: 7.82e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFTNTLLASLLVLIAFWLPQLNIYA--EKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWA 78
Cdd:MTH00012   1 MSLMMIPMMISLILPPLVLGAAWVLAARSTAdrEKTSPFECGFDPHKTARIPFSLRFFLLAIIFIVFDIEIVLLMPVPTI 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 195661263  79 LQAKNPTTVLITALLLISLLAASLAYEWTEKGLDWT 114
Cdd:MTH00012  81 LMTSTSKTVVYTSILFLLILVIGLIHEWREGSLDWS 116
ND3 MTH00161
NADH dehydrogenase subunit 3; Provisional
 3-113 2.33e-17

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177217 [Multi-domain]  Cd Length: 113  Bit Score: 71.35  E-value: 2.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   3 LILALFTNTLLASLLVLIAFWL--PQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00161   1 MILIILLIILLISIILMILASLlsKKSIMDREKSSPFECGFDPKSSARLPFSLRFFLIAIIFLIFDVEIALLLPMIFIFK 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 195661263  81 AKNPTTVLITALLLISLLAASLAYEWTEKGLDW 113
Cdd:MTH00161  81 TSNMMSWLITSSFFILILLLGLYYEWNQGALEW 113
ND3 MTH00202
NADH dehydrogenase subunit 3; Provisional
 1-113 3.84e-17

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 214455 [Multi-domain]  Cd Length: 117  Bit Score: 70.79  E-value: 3.84e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFTNTLLASLLVLIAFWL--PQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWA 78
Cdd:MTH00202   1 MLLILFMSILSILISSLLFLVSWMlsFRSLMDREKSSPFECGFDPKESARLPFSMRFFLLAVIFLVFDIEIALLLPLPLV 80

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 195661263  79 LQAKNPTTVLITALLLISLLAASLAYEWTEKGLDW 113
Cdd:MTH00202  81 LKSSWSKGGLLGGTIFLLILIGGLIHEWKEGSLDW 115
NuoA COG0838
NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH: ...
 3-69 3.15e-15

NADH:ubiquinone oxidoreductase subunit 3 (chain A) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 3 (chain A) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440600 [Multi-domain]  Cd Length: 117  Bit Score: 65.91  E-value: 3.15e-15
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195661263   3 LILALFTnTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEI 69
Cdd:COG0838    9 LIFLLVA-LGLALAMLLLSRLLGPKRPNPEKLSPYECGIEPVGDARIRFSVRYYLVALLFVIFDVEV 74
ND3 MTH00055
NADH dehydrogenase subunit 3; Provisional
 32-69 1.68e-14

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177128 [Multi-domain]  Cd Length: 118  Bit Score: 64.35  E-value: 1.68e-14
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 195661263  32 EKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEI 69
Cdd:MTH00055  37 EKVSVYECGFDPFESSRIPFSVRFFLVGILFLIFDLEI 74
PRK06602 PRK06602
NADH:ubiquinone oxidoreductase subunit A; Validated
 11-69 1.30e-13

NADH:ubiquinone oxidoreductase subunit A; Validated


Pssm-ID: 180638 [Multi-domain]  Cd Length: 121  Bit Score: 61.80  E-value: 1.30e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 195661263  11 TLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEI 69
Cdd:PRK06602  19 IGLGILLLVAGKLLGPRAPDREKNSPYESGFEAFGDARMKFDVRFYLVAILFVIFDLEA 77
ND3 MTH00018
NADH dehydrogenase subunit 3; Validated
 1-113 2.24e-13

NADH dehydrogenase subunit 3; Validated


Pssm-ID: 164592 [Multi-domain]  Cd Length: 113  Bit Score: 61.23  E-value: 2.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   1 MNLILALFTNTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPWALQ 80
Cdd:MTH00018   1 YGLFILLIFSVVLSALFSGASYFLGVKQPDREKVSAYECGFDPFGFPGRPFSIRFFLIGILFLIFDLEISFLFPWCVLYN 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 195661263  81 AKNPTTvLITALLLISLLAASLAYEWTEKGLDW 113
Cdd:MTH00018  81 QIAPFG-FWTMVGFLFILTLGLIYEWIKGGLEW 112
ND3 MTH00030
NADH dehydrogenase subunit 3; Provisional
 7-113 2.49e-09

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 164603 [Multi-domain]  Cd Length: 123  Bit Score: 51.09  E-value: 2.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263   7 LFTNTLLAS----LLVLIAFWLPQLNIY-----AEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEIALLLPLPW 77
Cdd:MTH00030   8 IFFSTLLGVgiilLLVSISFTLGNSRIGltkpdSEKSSIYECGFDPFGKIRTPFTIKFVLVGILFMIFDIEISFLFPWSI 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 195661263  78 ALQAKNPTTvLITALLLISLLAASLAYEWTEKGLDW 113
Cdd:MTH00030  88 VFNQLNLFS-FWIVYTFLIVLAIGLAYEWIKGGLEW 122
ndhC CHL00022
NADH dehydrogenase subunit 3
 12-68 4.28e-07

NADH dehydrogenase subunit 3


Pssm-ID: 176964 [Multi-domain]  Cd Length: 120  Bit Score: 44.98  E-value: 4.28e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 195661263  12 LLASLLVLIAFWLPQL----NIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLE 68
Cdd:CHL00022  15 IISSLIPILAFLISGLlapiSKGPEKLSSYESGIEPMGDAWLQFRIRYYMFALVFVVFDVE 75
ND3 MTH00092
NADH dehydrogenase subunit 3; Provisional
 1-69 5.39e-07

NADH dehydrogenase subunit 3; Provisional


Pssm-ID: 177155  Cd Length: 111  Bit Score: 44.50  E-value: 5.39e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195661263   1 MNLILALFTNTLLASLLVLIAFWLPQLNIYAEKVSPYECGFDPMGSARLPFSMKFFLVAITFLLFDLEI 69
Cdd:MTH00092   2 LVLIFVFLFTLLLLMLLYLLNFFLSVKKFDLLKVSSFECGFESVGKIQNSFSIHFFKIMLMFVIFDLEI 70
PRK07928 PRK07928
NADH dehydrogenase subunit A; Validated
 33-114 3.46e-03

NADH dehydrogenase subunit A; Validated


Pssm-ID: 181171 [Multi-domain]  Cd Length: 119  Bit Score: 34.65  E-value: 3.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195661263  33 KVSPYECGFDPMGSARLP--FSMKFFLVAITFLLFDLEIALLLPLPWALQAKnPTTVLITALLLISLLAASLAYEWTEKG 110
Cdd:PRK07928  37 KLEAYECGIEPTPQPAGGgrFPVKYYLTAMLFIVFDIEIVFLYPWAVSFDAL-GVFGLVEMALFMLTVFVAYAYVWRRGG 115


                 ....
gi 195661263 111 LDWT 114
Cdd:PRK07928 116 LEWD 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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