NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|211908561|ref|YP_002302308|]
View 

NADH dehydrogenase subunit 4L (mitochondrion) [Macaca thibetana]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.95e-40

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 127.74  E-value: 4.95e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  1 MTPTYMNVMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLIS 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 211908561 81 ISNTYGLDYVHNLSLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.95e-40

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 127.74  E-value: 4.95e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  1 MTPTYMNVMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLIS 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 211908561 81 ISNTYGLDYVHNLSLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
5-98 8.50e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 63.74  E-value: 8.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561   5 YMNVMLAFAISLLGMLTyRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLISISNT 84
Cdd:pfam00420  3 LLLSGLLFLIGLYGLLL-RRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRT 81

                         90
                 ....*....|....
gi 211908561  85 YGLDYVHNLSLLQC 98
Cdd:pfam00420 82 HGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 6.11e-05

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 38.51  E-value: 6.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561 12 FAISLLGMLTyRSHLVASLLCLEgmMMSLFIMTALIASNTHSPLIN--IMPIILLVFAACETAVGLALLISISNTYGLDY 89
Cdd:COG0713  14 FAIGLYGVLT-RRNLIVVLMSIE--LMLNAVNLNLVAFSRYLGDLDgqVFALFVIAVAAAEVAVGLAIIVALYRNRGTID 90


                ....*..
gi 211908561 90 VHNLSLL 96
Cdd:COG0713  91 VDDLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 4.95e-40

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 127.74  E-value: 4.95e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  1 MTPTYMNVMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLIS 80
Cdd:MTH00107  1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                        90
                ....*....|....*...
gi 211908561 81 ISNTYGLDYVHNLSLLQC 98
Cdd:MTH00107 81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.50e-23

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 86.05  E-value: 1.50e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  1 MTPTYMNVMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLIS 80
Cdd:MTH00125  1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                        90
                ....*....|....*...
gi 211908561 81 ISNTYGLDYVHNLSLLQC 98
Cdd:MTH00125 81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.28e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 83.09  E-value: 2.28e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  1 MTPTYMNVMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLIS 80
Cdd:MTH00126  1 MTPVHFSFSSAFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVA 80

                        90
                ....*....|....*...
gi 211908561 81 ISNTYGLDYVHNLSLLQC 98
Cdd:MTH00126 81 TARTHGTDRLQNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 1-98 9.91e-21

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 78.88  E-value: 9.91e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  1 MTPTYMNVMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLIS 80
Cdd:MTH00067  1 MSPTYFTFYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVA 80

                        90
                ....*....|....*...
gi 211908561 81 ISNTYGLDYVHNLSLLQC 98
Cdd:MTH00067 81 TTRTHGTDHLKNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
5-98 8.50e-15

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 63.74  E-value: 8.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561   5 YMNVMLAFAISLLGMLTyRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLISISNT 84
Cdd:pfam00420  3 LLLSGLLFLIGLYGLLL-RRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIYRT 81

                         90
                 ....*....|....
gi 211908561  85 YGLDYVHNLSLLQC 98
Cdd:pfam00420 82 HGTDDVDSLNLLKG 95
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 1.62e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 52.93  E-value: 1.62e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  9 MLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMtaLIASNTHSPLINIMPIILLVFAACETAVGLALLISISNTYGLD 88
Cdd:MTH00149 10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVM--MFSSSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                        90
                ....*....|
gi 211908561 89 YVHNLSLLQC 98
Cdd:MTH00149 88 YVSSLSSLKF 97
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 4-96 3.10e-10

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 51.87  E-value: 3.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  4 TYMNVMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLISISN 83
Cdd:MTH00181  1 MMFVFISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNR 80

                        90
                ....*....|...
gi 211908561 84 TYGLDYVHNLSLL 96
Cdd:MTH00181 81 THGSDHLLKFNLL 93
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 1.50e-08

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 47.61  E-value: 1.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  1 MTPTYMNVMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLIS 80
Cdd:MTH00043  1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                        90
                ....*....|....*..
gi 211908561 81 ISNTYGLDYVHNLSLLQ 97
Cdd:MTH00043 81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 9-98 2.75e-08

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 46.89  E-value: 2.75e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  9 MLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLIniMPIILLVFAACETAVGLALLISISNTYGLD 88
Cdd:MTH00188 10 LLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEKELY--LSLVLLTFAACEASVGLALLVSLIRSHGSD 87

                        90
                ....*....|
gi 211908561 89 YVHNLSLLQC 98
Cdd:MTH00188 88 YVSSLNLIKC 97
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 2.59e-06

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 42.05  E-value: 2.59e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  1 MTPTYMNVMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLInIMPIILLVFAACETAVGLALLIS 80
Cdd:MTH00013  1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFANQVNG-MLAIVLLTFGACEASLGLSLLVL 79

                        90
                ....*....|....*...
gi 211908561 81 ISNTYGLDYVHNLSLLQC 98
Cdd:MTH00013 80 MTRSYGNDMLKSLTSNKC 97
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 6.11e-05

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 38.51  E-value: 6.11e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561 12 FAISLLGMLTyRSHLVASLLCLEgmMMSLFIMTALIASNTHSPLIN--IMPIILLVFAACETAVGLALLISISNTYGLDY 89
Cdd:COG0713  14 FAIGLYGVLT-RRNLIVVLMSIE--LMLNAVNLNLVAFSRYLGDLDgqVFALFVIAVAAAEVAVGLAIIVALYRNRGTID 90


                ....*..
gi 211908561 90 VHNLSLL 96
Cdd:COG0713  91 VDDLNEL 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 5-92 1.46e-04

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 37.06  E-value: 1.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  5 YMNVMLAFAISLLGMLTYRSHLVASLLCLEGMMMSLFIMtaLIASNTHSPLINIMPIILLVFAACETAVGLALLISISNT 84
Cdd:MTH00162  4 LLIFLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFL--LFLYLSFFNYELYFLLFFLTFSVCEGALGLSILVSMIRS 81


                ....*...
gi 211908561 85 YGLDYVHN 92
Cdd:MTH00162 82 HGNDYFSS 89
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
12-96 4.09e-03

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 33.61  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 211908561  12 FAISLLGMLTyRSHLVASLLCLEGMMMSLFIMTALIASNTHSPLINIMPIILLVFAACETAVGLALLISISNTYGLDYVH 91
Cdd:PRK05715  15 FCIGLVGLLL-RRNAIVVLMSIELMLNAVNLNFVAFSSYLGDLDGQVFAFFVITVAAAEAAIGLAILLQLYRNRGTIDVD 93


                 ....*
gi 211908561  92 NLSLL 96
Cdd:PRK05715  94 DLNEL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH