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Conserved domains on  [gi|238866958|ref|YP_002929436|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Eulemur macaco macaco]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.19e-78

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 230.07  E-value: 3.19e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   1 MYAMFLLSILFVLGFVSIASKPSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00109   3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958  81 WGSNVVIWGMVLLGVSVELFMVMWMVEHGGLGVEGIFNGMEDWVSFGGKGGGVVREDCLGVASLYDNASWFVAVAGWSLF 160
Cdd:MTH00109  83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                        170
                 ....*....|..
gi 238866958 161 VSVLIVIEIIRG 172
Cdd:MTH00109 163 IGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.19e-78

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 230.07  E-value: 3.19e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   1 MYAMFLLSILFVLGFVSIASKPSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00109   3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958  81 WGSNVVIWGMVLLGVSVELFMVMWMVEHGGLGVEGIFNGMEDWVSFGGKGGGVVREDCLGVASLYDNASWFVAVAGWSLF 160
Cdd:MTH00109  83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                        170
                 ....*....|..
gi 238866958 161 VSVLIVIEIIRG 172
Cdd:MTH00109 163 IGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-169 7.40e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.04  E-value: 7.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   18 IASKPSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAM-ATEEYPETWGSNVVIWGMVLLGVS 96
Cdd:pfam00499   3 VVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGLLL 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238866958   97 VELFMVMWMVEHGGLGVEGIFNGMEDWVSFGgkgggvvredclgvASLYDNASWFVAVAGWSLFVSVLIVIEI 169
Cdd:pfam00499  83 LALLLLVLLSASLTPAAAAAAPDVGNIEAIG--------------ELLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 3.19e-78

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 230.07  E-value: 3.19e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   1 MYAMFLLSILFVLGFVSIASKPSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00109   3 MYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPET 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958  81 WGSNVVIWGMVLLGVSVELFMVMWMVEHGGLGVEGIFNGMEDWVSFGGKGGGVVREDCLGVASLYDNASWFVAVAGWSLF 160
Cdd:MTH00109  83 WVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSLF 162

                        170
                 ....*....|..
gi 238866958 161 VSVLIVIEIIRG 172
Cdd:MTH00109 163 IGVFVIIEITRG 174
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 5.94e-34

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 117.55  E-value: 5.94e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   1 MYAMFLLSILFVLGFVSIASKPSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00138   2 TYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958  81 WGSNVVIWGMVLLGVSVELFMVMWMVEHGGlgvegifngmEDWVSFGG-KGGGVVREDCLGVASLYDNASWFVAVAGWSL 159
Cdd:MTH00138  82 WGSWSVLGYVVGYLVGVVLAAGLFWGGWYE----------GSWVVVDElKEFSVLRGDVGGVALMYSSGGGMLVICAWVL 151

                        170
                 ....*....|...
gi 238866958 160 FVSVLIVIEIIRG 172
Cdd:MTH00138 152 LLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 2.13e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 111.09  E-value: 2.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   1 MYAMFLLSILFVLGFVSIASKPSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00065   2 MYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958  81 WGSNVViwgMVLLGVSVELFMVMWMVEHGGLGVEGIFngmedwvSFGGKGGGVVREDCLGVASLYDNASWFVAVAGWSLF 160
Cdd:MTH00065  82 WGSWSV---LVYVLFYLLLLIVGYILFGCNFSLEFLF-------TNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVLL 151

                        170
                 ....*....|..
gi 238866958 161 VSVLIVIEIIRG 172
Cdd:MTH00065 152 LTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 3.33e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 97.90  E-value: 3.33e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   1 MYAMFLLSILFVLGFVSIASKPSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00115   2 MYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPEA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958  81 WGSNVVIWGMVLLGVSVelfMVMWMVEHGGLGVEGIFNGMEDWVsfggkGGGVVREDCLGVASLYDNASWFVAVAGWSLF 160
Cdd:MTH00115  82 WGDWGVVGYVVGFVLVV---VVVGVVVGGLWGMEGVGVVTVDSG-----GLFVVRLDFSGVSLFYSSGGGGLLVCGWGLL 153

                        170
                 ....*....|..
gi 238866958 161 VSVLIVIEIIRG 172
Cdd:MTH00115 154 LTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 1.08e-15

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 70.40  E-value: 1.08e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   1 MYAMFLLSILFVLGFVSIASKPSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPET 80
Cdd:MTH00214   2 LYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPES 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958  81 WGSNVVIWGMVLLGVSVELFMVMWMVEHGGLGVEGifngmedwvsfggkGGGVVREDCLGVASLYDNASWFVAVAGWSLF 160
Cdd:MTH00214  82 WGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMG--------------VDEANNLDLSGVSDLYSRGFFLLLLGGVVLF 147

                        170
                 ....*....|..
gi 238866958 161 VSVLIVIEIIRG 172
Cdd:MTH00214 148 LVLFVVLELVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 23-172 1.20e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 59.53  E-value: 1.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958  23 SPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSNVVIwgmvllgvSVELFMV 102
Cdd:MTH00045  22 SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPSVSNLGEVL--------VLSLLLS 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238866958 103 MWmvehgglgvegIFNGMEDWVSFGGKGGG-VVREDCLGVASLYDNASWFVAVAGWSLFVSVLIVIEIIRG 172
Cdd:MTH00045  94 LW-----------VFISFDNFLELSNNNWSlVSLSDLVGSSELYNSGGLYLLLGGFILLVALVVALVISFG 153
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
18-169 7.40e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.04  E-value: 7.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   18 IASKPSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAM-ATEEYPETWGSNVVIWGMVLLGVS 96
Cdd:pfam00499   3 VVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGLLL 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 238866958   97 VELFMVMWMVEHGGLGVEGIFNGMEDWVSFGgkgggvvredclgvASLYDNASWFVAVAGWSLFVSVLIVIEI 169
Cdd:pfam00499  83 LALLLLVLLSASLTPAAAAAAPDVGNIEAIG--------------ELLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 1-77 2.83e-06

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 45.00  E-value: 2.83e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 238866958   1 MYAMFLLSILFVLGFVSIASKpSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATEEY 77
Cdd:MTH00212   1 MLLSLLLSLLLLLMLLFPLSA-HPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 1-128 8.16e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 41.03  E-value: 8.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   1 MYAMFLLSILFVLGFVSIASKpSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAMATeEYPET 80
Cdd:MTH00152   1 MSLMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLSP-NPLFG 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 238866958  81 WGSNVVIWGMVLLGVSVELFMVMWMVEHGGLGVEGIFNGMEDWVSFGG 128
Cdd:MTH00152  79 SNFKFVFFSLTLFGFLGLFFFFLYLYSSGGLSLSSLFDGSSGSLSFGG 126
ND6 MTH00015
NADH dehydrogenase subunit 6; Validated
 6-72 6.21e-03

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 164590  Cd Length: 155  Bit Score: 35.60  E-value: 6.21e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238866958   6 LLSILFVLGFVSIAS---KPSPIYGGVGLIVSGALGCVIIMGFGGSFMGLMVFLIYLGGMLVVFGYTTAM 72
Cdd:MTH00015   2 SLSFFLILMISLTCSlflATTPITLGINILMMALLLATTMASALSSWFAFLTFLIYVGGMLVMFAYFLAL 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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