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Conserved domains on  [gi|304322892|ref|YP_003856732|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Lepilemur hubbardorum]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 8.81e-79

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 231.61  E-value: 8.81e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   1 MTYVMFLLSVIFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892  81 TWGSSVIVWGSLLMGLIMELLVVVWVVGQDSFEVVVGLDDLEDWVVFTGKEISTVREDSLGVAALYNYVNWFMVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 304322892 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 8.81e-79

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 231.61  E-value: 8.81e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   1 MTYVMFLLSVIFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892  81 TWGSSVIVWGSLLMGLIMELLVVVWVVGQDSFEVVVGLDDLEDWVVFTGKEISTVREDSLGVAALYNYVNWFMVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 304322892 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 2.96e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.51  E-value: 2.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   21 SKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAM-ATEEYPETWGSSVIVWGSLLMGLIME 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 304322892  100 LLVVVWVVGQDSfevvvglddledwVVFTGKEISTVREDSLGVAALYNYVnWFMVVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLT-------------PAAAAAAPDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 8.81e-79

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 231.61  E-value: 8.81e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   1 MTYVMFLLSVIFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892  81 TWGSSVIVWGSLLMGLIMELLVVVWVVGQDSFEVVVGLDDLEDWVVFTGKEISTVREDSLGVAALYNYVNWFMVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 304322892 161 FVSVLIVIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 8.37e-35

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 119.86  E-value: 8.37e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   1 MTYVMFLLSVIFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892  81 TWGsSVIVWGSLLMGLIMELLVVVWVVGQDSFEVVVGLDDLedwvvftgKEISTVREDSLGVAALYNYVNWFMVVAGWSL 160
Cdd:MTH00138  81 SWG-SWSVLGYVVGYLVGVVLAAGLFWGGWYEGSWVVVDEL--------KEFSVLRGDVGGVALMYSSGGGMLVICAWVL 151

                        170
                 ....*....|..
gi 304322892 161 FVSVLIVIEIIR 172
Cdd:MTH00138 152 LLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 1.87e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 111.48  E-value: 1.87e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   1 MTYVMFLLSVIFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892  81 TWGsSVIVWGSLLMGLIMelLVVVWVvgqdsfeVVVGLDDLEDWVVFTGKEISTVREDSLGVAALYNYVNWFMVVAGWSL 160
Cdd:MTH00065  81 AWG-SWSVLVYVLFYLLL--LIVGYI-------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|..
gi 304322892 161 FVSVLIVIEIIR 172
Cdd:MTH00065 151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 7.37e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 97.13  E-value: 7.37e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   1 MTYVMFLLSVIFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892  81 TWGSSVIVWGSLLMGLIMELLVVVWVVGQDSFEVVVGLDDLEDWVVftgkeistVREDSLGVAALYNYVNWFMVVAGWSL 160
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGLFV--------VRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|..
gi 304322892 161 FVSVLIVIEIIR 172
Cdd:MTH00115 153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 1.99e-13

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 64.24  E-value: 1.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   1 MTYVMFLLSVIFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892  81 TWGSsvivwGSLLMGLIMELLVVVWVvgqdsfeVVVGLDDLEDWVVFTGKEISTVreDSLGVAALYNYVNWFMVVAGWSL 160
Cdd:MTH00214  81 SWGG-----WSVLLFFLFYLLGLGFV-------GFYFYGGWEMLSWMGVDEANNL--DLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|..
gi 304322892 161 FVSVLIVIEIIR 172
Cdd:MTH00214 147 FLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-170 4.09e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 57.99  E-value: 4.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   1 MTYVMFLLSVIFVLGFMSFSSkpSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPe 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892  81 twgsSVIVWGSLlmgLIMELLVVVWvvgqdsfeVVVGLDDLEDWVVFTGKEISTVREDSLGVaaLYNYVNWFMVVAGWSL 160
Cdd:MTH00045  78 ----SVSNLGEV---LVLSLLLSLW--------VFISFDNFLELSNNNWSLVSLSDLVGSSE--LYNSGGLYLLLGGFIL 140

                        170
                 ....*....|
gi 304322892 161 FVSVLIVIEI 170
Cdd:MTH00045 141 LVALVVALVI 150
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 2.96e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 52.51  E-value: 2.96e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   21 SKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAM-ATEEYPETWGSSVIVWGSLLMGLIME 99
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 304322892  100 LLVVVWVVGQDSfevvvglddledwVVFTGKEISTVREDSLGVAALYNYVnWFMVVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLT-------------PAAAAAAPDVGNIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 5-111 1.18e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 43.07  E-value: 1.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 304322892   5 MFLLSVIFVLGFMSFSSKPSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMAteeyPETWGS 84
Cdd:MTH00212   3 LSLLLSLLLLLMLLFPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALS----PNEHLF 78

                         90       100
                 ....*....|....*....|....*..
gi 304322892  85 SVIVWGSLLMGLIMELLVVVWVVGQDS 111
Cdd:MTH00212  79 FKKYFKGFGMILISLNLYLLLMTLGSS 105
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 4-74 1.02e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 37.94  E-value: 1.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 304322892   4 VMFLLSVIFVLGFMSFSSKpSPIYGGVGLVVSGAVGCIIIMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMA 74
Cdd:MTH00152   3 LMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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