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Conserved domains on  [gi|311978316|ref|YP_003987438|]
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putative KilA-N domain-containing protein [Acanthamoeba polyphaga mimivirus]

Protein Classification

KilA-N and DUF3627 domain-containing protein( domain architecture ID 10516377)

protein containing domains KilA-N, PRK12704, and DUF3627

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KilA-N pfam04383
KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved ...
 55-160 4.29e-18

KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.


:

Pssm-ID: 367917  Cd Length: 107  Bit Score: 78.52  E-value: 4.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316   55 GNYLNLKVIIM-NDNGYINVTKLIQQAN-KEKKMGDWNKNKDSKNIVKSACEYTGLTEDKLFIIKTGGNNStIRGTYAHP 132
Cdd:pfam04383   1 IQYNDFEIIIRrDKDGYINATKLCKAAGeKTKRFRNWLRLESTKELIEELEEENNIPKIITIIGRKGKGGR-LQGTYVHP 79

                          90       100
                  ....*....|....*....|....*...
gi 311978316  133 IIVAQIAGWASSDFAIKASVIINDYIAK 160
Cdd:pfam04383  80 DLALAIASWISPEFALKVSKIIDEYKSG 107
DUF3627 pfam12299
Protein of unknown function (DUF3627); This domain family is found in bacteria and viruses, ...
 222-301 1.02e-17

Protein of unknown function (DUF3627); This domain family is found in bacteria and viruses, and is approximately 90 amino acids in length. The family is found in association with pfam02498.


:

Pssm-ID: 372024  Cd Length: 93  Bit Score: 76.97  E-value: 1.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316  222 INDKLDVVCNDRVVQSDTNT--HRFVIMKNNSdkEDYEYHSIRRLKNSVNNAVKEYKELYPDAEIIMNLGYTPNSICLWN 299
Cdd:pfam12299   1 VNRKLGIVVEDRNPKPDDKKlrHRFILLKRND--ERYEYYFIRGQDKYIKKRLKRYKNGYPDLEIILDIKYNPNPINLFN 78


                  ..
gi 311978316  300 NI 301
Cdd:pfam12299  79 RI 80
COG2433 super family cl43687
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
163-208 1.63e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


The actual alignment was detected with superfamily member COG2433:

Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 40.23  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 311978316 163 FKEHEKIIEEKDKTIKRRDKKIDQLNNKMDDLLKKNDKMSKRIKRL 208
Cdd:COG2433  453 ARSEERREIRKDREISRLDREIERLERELEEERERIEELKRKLERL 498
 
Name Accession Description Interval E-value
KilA-N pfam04383
KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved ...
 55-160 4.29e-18

KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.


Pssm-ID: 367917  Cd Length: 107  Bit Score: 78.52  E-value: 4.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316   55 GNYLNLKVIIM-NDNGYINVTKLIQQAN-KEKKMGDWNKNKDSKNIVKSACEYTGLTEDKLFIIKTGGNNStIRGTYAHP 132
Cdd:pfam04383   1 IQYNDFEIIIRrDKDGYINATKLCKAAGeKTKRFRNWLRLESTKELIEELEEENNIPKIITIIGRKGKGGR-LQGTYVHP 79

                          90       100
                  ....*....|....*....|....*...
gi 311978316  133 IIVAQIAGWASSDFAIKASVIINDYIAK 160
Cdd:pfam04383  80 DLALAIASWISPEFALKVSKIIDEYKSG 107
DUF3627 pfam12299
Protein of unknown function (DUF3627); This domain family is found in bacteria and viruses, ...
 222-301 1.02e-17

Protein of unknown function (DUF3627); This domain family is found in bacteria and viruses, and is approximately 90 amino acids in length. The family is found in association with pfam02498.


Pssm-ID: 372024  Cd Length: 93  Bit Score: 76.97  E-value: 1.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316  222 INDKLDVVCNDRVVQSDTNT--HRFVIMKNNSdkEDYEYHSIRRLKNSVNNAVKEYKELYPDAEIIMNLGYTPNSICLWN 299
Cdd:pfam12299   1 VNRKLGIVVEDRNPKPDDKKlrHRFILLKRND--ERYEYYFIRGQDKYIKKRLKRYKNGYPDLEIILDIKYNPNPINLFN 78


                  ..
gi 311978316  300 NI 301
Cdd:pfam12299  79 RI 80
PHA03096 PHA03096
p28-like protein; Provisional
 48-255 5.46e-17

p28-like protein; Provisional


Pssm-ID: 222981 [Multi-domain]  Cd Length: 284  Bit Score: 79.85  E-value: 5.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316  48 INDEFSWGNYLNLKVIIMNDNGYINVTKLIQQANKEKKmgDWNKNKDSKNIVKSACEYTGLTEDKLFIIKTGGNNSTIRG 127
Cdd:PHA03096   9 IDEKFSYIKYNDVELIIMKSNGYVNVTKLCKSRNKDFT--RWKRLSSSKRLIETIKKNNSVDGDDPIIYVERGYNNEING 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316 128 TYAHPIIVAQIAGWASSDFAIKASVIINDYIAKqmfkehEKIIEEKDKTIKRRDKKIDQLNNKMDDLLKKNDKMSKRIK- 206
Cdd:PHA03096  87 FYVHPDLLPYIAKWISPDFAIKVSKLINYYNAN------VYMNVEKDEDNCYKGKYCEYLHGDICDICEKYLLHPTDIKq 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 311978316 207 RLVDTADDLRNQNDDINDKLDVVCNDRVVQSDTNTHRFVIMKNNSDKED 255
Cdd:PHA03096 161 RYNEQKTCLSYQLRLLLSKICGICLENIKAKYIIKKYYGILSEIKHEFN 209
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
163-208 1.63e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 40.23  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 311978316 163 FKEHEKIIEEKDKTIKRRDKKIDQLNNKMDDLLKKNDKMSKRIKRL 208
Cdd:COG2433  453 ARSEERREIRKDREISRLDREIERLERELEEERERIEELKRKLERL 498
COG6 pfam06419
Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi ...
 158-229 5.32e-03

Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi complex, which is composed of eight different subunits and is required for normal golgi morphology and localization.


Pssm-ID: 461904  Cd Length: 611  Bit Score: 38.74  E-value: 5.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 311978316  158 IAKQMFKEHEKIIEE---KDKTIKRRDKKIDQLNNKMDDLLKKNDKMSKRIKRLVDTADDLRNQNDDINDKLDVV 229
Cdd:pfam06419  24 IEKELLKINGEFLKEfgpVVEQLKRIETDVEKLNNSCDEMRKRLSAAKEDTAPLLEEASSLQEQKKKIELKQKLL 98
 
Name Accession Description Interval E-value
KilA-N pfam04383
KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved ...
 55-160 4.29e-18

KilA-N domain; The amino-terminal module of the D6R/N1R proteins defines a novel, conserved DNA-binding domain (the KilA-N domain) that is found in a wide range of proteins of large bacterial and eukaryotic DNA viruses. The KilA-N domain family also includes the previously defined APSES domain. The KilA-N and APSES domains may also share a common fold with the nucleic acid-binding modules of the LAGLIDADG nucleases and the amino-terminal domains of the tRNA endonuclease.


Pssm-ID: 367917  Cd Length: 107  Bit Score: 78.52  E-value: 4.29e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316   55 GNYLNLKVIIM-NDNGYINVTKLIQQAN-KEKKMGDWNKNKDSKNIVKSACEYTGLTEDKLFIIKTGGNNStIRGTYAHP 132
Cdd:pfam04383   1 IQYNDFEIIIRrDKDGYINATKLCKAAGeKTKRFRNWLRLESTKELIEELEEENNIPKIITIIGRKGKGGR-LQGTYVHP 79

                          90       100
                  ....*....|....*....|....*...
gi 311978316  133 IIVAQIAGWASSDFAIKASVIINDYIAK 160
Cdd:pfam04383  80 DLALAIASWISPEFALKVSKIIDEYKSG 107
DUF3627 pfam12299
Protein of unknown function (DUF3627); This domain family is found in bacteria and viruses, ...
 222-301 1.02e-17

Protein of unknown function (DUF3627); This domain family is found in bacteria and viruses, and is approximately 90 amino acids in length. The family is found in association with pfam02498.


Pssm-ID: 372024  Cd Length: 93  Bit Score: 76.97  E-value: 1.02e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316  222 INDKLDVVCNDRVVQSDTNT--HRFVIMKNNSdkEDYEYHSIRRLKNSVNNAVKEYKELYPDAEIIMNLGYTPNSICLWN 299
Cdd:pfam12299   1 VNRKLGIVVEDRNPKPDDKKlrHRFILLKRND--ERYEYYFIRGQDKYIKKRLKRYKNGYPDLEIILDIKYNPNPINLFN 78


                  ..
gi 311978316  300 NI 301
Cdd:pfam12299  79 RI 80
PHA03096 PHA03096
p28-like protein; Provisional
 48-255 5.46e-17

p28-like protein; Provisional


Pssm-ID: 222981 [Multi-domain]  Cd Length: 284  Bit Score: 79.85  E-value: 5.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316  48 INDEFSWGNYLNLKVIIMNDNGYINVTKLIQQANKEKKmgDWNKNKDSKNIVKSACEYTGLTEDKLFIIKTGGNNSTIRG 127
Cdd:PHA03096   9 IDEKFSYIKYNDVELIIMKSNGYVNVTKLCKSRNKDFT--RWKRLSSSKRLIETIKKNNSVDGDDPIIYVERGYNNEING 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316 128 TYAHPIIVAQIAGWASSDFAIKASVIINDYIAKqmfkehEKIIEEKDKTIKRRDKKIDQLNNKMDDLLKKNDKMSKRIK- 206
Cdd:PHA03096  87 FYVHPDLLPYIAKWISPDFAIKVSKLINYYNAN------VYMNVEKDEDNCYKGKYCEYLHGDICDICEKYLLHPTDIKq 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 311978316 207 RLVDTADDLRNQNDDINDKLDVVCNDRVVQSDTNTHRFVIMKNNSDKED 255
Cdd:PHA03096 161 RYNEQKTCLSYQLRLLLSKICGICLENIKAKYIIKKYYGILSEIKHEFN 209
PHA02929 PHA02929
N1R/p28-like protein; Provisional
 56-165 1.73e-05

N1R/p28-like protein; Provisional


Pssm-ID: 222944 [Multi-domain]  Cd Length: 238  Bit Score: 45.54  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 311978316  56 NYLNLKVIIMNDNGYINVTKLIQQAnkEKKMGDWNKNKDSKNIVKSACEYTGLTEDKL-FIIKTGGNNSTIRGTYAHPII 134
Cdd:PHA02929  14 NGECIKIIILSSNNYINITKLCKPM--KKSFCNWKNLKRSRQIIINISIEENIKVDKLsFRIYKSKYTKQIHGVFIHPKL 91

                         90       100       110
                 ....*....|....*....|....*....|.
gi 311978316 135 VAQIAGWASSDFAIKASVIINDYIAKQMFKE 165
Cdd:PHA02929  92 LKYVLNWISEEYCAKVLSIINEYNQKILKNK 122
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
163-208 1.63e-03

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 40.23  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 311978316 163 FKEHEKIIEEKDKTIKRRDKKIDQLNNKMDDLLKKNDKMSKRIKRL 208
Cdd:COG2433  453 ARSEERREIRKDREISRLDREIERLERELEEERERIEELKRKLERL 498
COG6 pfam06419
Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi ...
 158-229 5.32e-03

Conserved oligomeric complex COG6; COG6 is a component of the conserved oligomeric golgi complex, which is composed of eight different subunits and is required for normal golgi morphology and localization.


Pssm-ID: 461904  Cd Length: 611  Bit Score: 38.74  E-value: 5.32e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 311978316  158 IAKQMFKEHEKIIEE---KDKTIKRRDKKIDQLNNKMDDLLKKNDKMSKRIKRLVDTADDLRNQNDDINDKLDVV 229
Cdd:pfam06419  24 IEKELLKINGEFLKEfgpVVEQLKRIETDVEKLNNSCDEMRKRLSAAKEDTAPLLEEASSLQEQKKKIELKQKLL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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