NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|529217266|ref|YP_008378983|]
View 

NADH dehydrogenase subunit 2 (mitochondrion) [Eulemur rufus]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475899)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-347 7.03e-164

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 461.24  E-value: 7.03e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   1 MKPIVLMPIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMY 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  81 SGQWGITNMCNQLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPNILLLITTL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 161 SIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTM 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 241 TITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKWQFQQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*..
gi 529217266 321 KQMFLLPPLIILTTLTLPLSPALLILN 347
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-347 7.03e-164

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 461.24  E-value: 7.03e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   1 MKPIVLMPIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMY 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  81 SGQWGITNMCNQLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPNILLLITTL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 161 SIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTM 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 241 TITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKWQFQQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*..
gi 529217266 321 KQMFLLPPLIILTTLTLPLSPALLILN 347
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-286 1.92e-22

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 95.46  E-value: 1.92e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   23 SSHWLLMWIGLEINMLAIIP-ILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMYSGQWGITNMCNQ--------- 92
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKAltgglnssg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   93 --LISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLL-TWQKLAPISI--MLQIYPSINP---NILLLITTLSIMV 164
Cdd:pfam00361  81 llLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLirRSLLYLPSSPfiqQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  165 GGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTML---------NINTSTTTLALSNLWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLflcagsviyRRVHTRNIRDYGGLAK 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 529217266  236 KTPTMTITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILA 286
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 9-297 9.45e-20

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 89.62  E-value: 9.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266    9 IMLTIFMGTTLTMISSHWLLMWIGLEINMLAI-IPILMEKANPRSTEAATKYFLTQATASMLLMFTIvtnAMYSGQWGIT 87
Cdd:TIGR01770 107 LLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGI---SLIYGFTGSL 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   88 NMCNQLISFS---------------IILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSI--- 149
Cdd:TIGR01770 184 NFEDLLLFLSngmlnisllllgivlILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfg 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  150 ----NPNILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLML----TIAMFTML-- 219
Cdd:TIGR01770 264 fseaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIyalmSLGAFGVLsl 343

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  220 ----NINTSTTTLALSNLWNKTPTMTITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLR 295
Cdd:TIGR01770 344 lrsyKDEWIEYISDFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLR 423


                  ..
gi 529217266  296 LI 297
Cdd:TIGR01770 424 VV 425
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 9-298 1.86e-19

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 89.02  E-value: 1.86e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   9 IMLTIFMGTTLTMISSHWLLMWIGLEINMLAI-IPILMEKANPRSTEAATKYFLTQATASMLLMFTIvtnAMYSGQWGIT 87
Cdd:COG1007  107 LLLFATLGMMLMASANDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGI---SLLYGATGSL 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  88 N------------MCNQLISFSIIL---ALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPN 152
Cdd:COG1007  184 NlagiaaalaaggANSPLLLLGLVLvlaGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEAFPG 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 153 -------ILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMycpSMTTLN-------LLIYLMLTIAMFTM 218
Cdd:COG1007  264 laadwqlLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLA---AGTPLGvsaalfyLLAYLFMNLGAFAV 340

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 219 LNI----NTSTTTLA-LSNLWNKTPTMTITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFY 293
Cdd:COG1007  341 ILLlsrkGGEAEEIEdLAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYY 420


                 ....*
gi 529217266 294 LRLIY 298
Cdd:COG1007  421 LRVVK 425
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-347 7.03e-164

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 461.24  E-value: 7.03e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   1 MKPIVLMPIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMY 80
Cdd:MTH00105   1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  81 SGQWGITNMCNQLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPNILLLITTL 160
Cdd:MTH00105  81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 161 SIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTM 240
Cdd:MTH00105 161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 241 TITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKWQFQQT 320
Cdd:MTH00105 241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFENT 320

                        330       340
                 ....*....|....*....|....*..
gi 529217266 321 KQMFLLPPLIILTTLTLPLSPALLILN 347
Cdd:MTH00105 321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-346 4.11e-117

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 342.55  E-value: 4.11e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   1 MKPIVLMPIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMY 80
Cdd:MTH00135   1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  81 SGQWGITNMCNQLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSiNPNILLLITTL 160
Cdd:MTH00135  81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 161 SIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTM 240
Cdd:MTH00135 160 STLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 241 TITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKWQFQQT 320
Cdd:MTH00135 240 TALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319

                        330       340
                 ....*....|....*....|....*.
gi 529217266 321 KQMFLLPPLIILTTLTLPLSPALLIL 346
Cdd:MTH00135 320 QLTLPLAISTTATLMLLPLTPAILAL 345
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-346 3.24e-105

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 312.24  E-value: 3.24e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   1 MKPIVLMPIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMY 80
Cdd:MTH00070   1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  81 SGQWGITNMCNQLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPNILLLITTL 160
Cdd:MTH00070  81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 161 SIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTM 240
Cdd:MTH00070 161 STLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 241 TITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKWQFqQT 320
Cdd:MTH00070 241 TSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRF-KN 319

                        330       340
                 ....*....|....*....|....*.
gi 529217266 321 KQMFLLPPLIILTTLTLPLSPALLIL 346
Cdd:MTH00070 320 KTNNLLSLTIILSLMLLPITPTILNL 345
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-344 4.81e-105

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 311.76  E-value: 4.81e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   1 MKPIVLMPIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMY 80
Cdd:MTH00112   1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  81 SGQWGITNMCNQLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPNILLLITTL 160
Cdd:MTH00112  81 TGQWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 161 SIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTM 240
Cdd:MTH00112 161 STLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 241 TITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKWQFqQT 320
Cdd:MTH00112 241 NTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRT-KP 319

                        330       340
                 ....*....|....*....|....
gi 529217266 321 KQMFLLPPLIILTTLTLPLSPALL 344
Cdd:MTH00112 320 KKNTLTATLTTLSTLLLPLSPMIL 343
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-346 1.96e-78

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 243.72  E-value: 1.96e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   1 MKPIVLMPIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMY 80
Cdd:MTH00200   1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  81 SGQWGITNMCNQLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPNILLLITTL 160
Cdd:MTH00200  81 SGQWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 161 SIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTM 240
Cdd:MTH00200 161 SVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPIL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 241 TITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKWQFQQT 320
Cdd:MTH00200 241 SMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSN 320

                        330       340
                 ....*....|....*....|....*.
gi 529217266 321 KQmFLLPPLIILTTLTLPLSPALLIL 346
Cdd:MTH00200 321 SN-LLVGLLLLLSILGLPLTPQLLFL 345
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-346 1.08e-77

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 242.14  E-value: 1.08e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   1 MKPIVLMPIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMY 80
Cdd:MTH00041   1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  81 SGQWGITNMCNQLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPNILLLITTL 160
Cdd:MTH00041  81 SGSWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGIL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 161 SIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTM 240
Cdd:MTH00041 161 SVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 241 TITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKWQFQ-- 318
Cdd:MTH00041 241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSISLFSWRNSgn 320

                        330       340
                 ....*....|....*....|....*...
gi 529217266 319 QTKQMFLLPPLIILTTLTLPLSPALLIL 346
Cdd:MTH00041 321 ITVYGVILSILSSISILGLLLIPLFLSF 348
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 10-315 2.59e-46

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 160.05  E-value: 2.59e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  10 MLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMYSGQWGITNM 89
Cdd:MTH00144  10 LFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFSMSL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  90 cnqlisfsIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINP-NILLLITTLSIMVGGWG 168
Cdd:MTH00144  90 --------LLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLaYLLCVISVLSALVGSIG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 169 GLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLwNKTPTMTITILISL 248
Cdd:MTH00144 162 GLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSL-KPSYKTGLSIISLL 240

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 529217266 249 LSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKW 315
Cdd:MTH00144 241 LSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKV 307
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-347 2.69e-45

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 157.68  E-value: 2.69e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   1 MKPIVLMPIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMy 80
Cdd:MTH00160   2 MMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  81 sgqwgITNMCNQLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIypsINPNILLLITTL 160
Cdd:MTH00160  81 -----NLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYL---INNNFIIIIIIL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 161 SIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTM 240
Cdd:MTH00160 153 SAIIGAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKI 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 241 TITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLtmfptLNNLKMKWQFQQT 320
Cdd:MTH00160 233 KFLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLM-----LNYNKNKWNLKKK 307

                        330       340
                 ....*....|....*....|....*..
gi 529217266 321 KQMFLLPPLIILTTLTLPLSPALLILN 347
Cdd:MTH00160 308 KNKFSLILNFLSFISLFGLILSSLLFL 334
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 6-312 4.79e-42

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 149.16  E-value: 4.79e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   6 LMPIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMYSGQWG 85
Cdd:MTH00011   8 MFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSLLK 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  86 ITNmcnqliSFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPNILLLITTLSIMVG 165
Cdd:MTH00011  88 NIT------ALMLLVSLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 166 GWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTMTITIL 245
Cdd:MTH00011 162 GLGGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLF 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 529217266 246 ISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYStSLTMFPTLNNLK 312
Cdd:MTH00011 242 IMLLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFN-FMYLSPTFSSLK 307
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 11-335 4.48e-35

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 130.18  E-value: 4.48e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  11 LTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVtnAMYSGQWGITnmc 90
Cdd:MTH00197   5 FIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGS--LSFSNLYLSL--- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  91 nqLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPIsiMLQIYPSINPNILLLITTLSIMVGGWGGL 170
Cdd:MTH00197  80 --LSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPL--LILAFNSSSFMGLLICSVLSSLIGGIGGM 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 171 NQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTLALSNLWNKTPTMTITILISLLS 250
Cdd:MTH00197 156 NQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLS 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 251 LGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKWQFQQTKQ---MFLLP 327
Cdd:MTH00197 236 LGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLILSNWMINFLMKINLLYSGLFillMMMLP 315


                 ....*...
gi 529217266 328 PLIILTTL 335
Cdd:MTH00197 316 LLMIFTMI 323
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 9-298 2.33e-23

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 100.09  E-value: 2.33e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   9 IMLTIFMGTTLTMISSHWLLMWIGLEINMLAI-IPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMYSGQWGIT 87
Cdd:MTH00199 102 LILIVALGSLLLVSSINWLSIYLAIELQTLTLfILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGETSIQ 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  88 NMCNQLIS----FSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINpnILLLITTLSIM 163
Cdd:MTH00199 182 GINSILTGdvgkILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTN--VVLICAVLSII 259

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 164 VGGWGGLNQTQLRKIMAYSSIAHMGWMM------------AILMYcpsmttlnLLIYLMLTIAMFTMLNINTSTTTL--A 229
Cdd:MTH00199 260 YGAIGALNQTKIKRLLAYSGIGHMGFILfgvaigsfesiqASLIY--------MIIYVIMSICSFSIILSLKLTKGLivE 331

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 529217266 230 LSNLWNKTPTMTITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIY 298
Cdd:MTH00199 332 VSGLSRKNPVIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRVVQ 400
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-286 1.92e-22

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 95.46  E-value: 1.92e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   23 SSHWLLMWIGLEINMLAIIP-ILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMYSGQWGITNMCNQ--------- 92
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKAltgglnssg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   93 --LISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLL-TWQKLAPISI--MLQIYPSINP---NILLLITTLSIMV 164
Cdd:pfam00361  81 llLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGYGLirRSLLYLPSSPfiqQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  165 GGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLMLTIAMFTML---------NINTSTTTLALSNLWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGAGTIYGIQAAIFHLLTHGLFSAGLflcagsviyRRVHTRNIRDYGGLAK 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 529217266  236 KTPTMTITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILA 286
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 13-297 1.71e-21

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 93.94  E-value: 1.71e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  13 IFMGTTLTMISSHWLLMWIGLEINMLAI-IPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMYSGQWG---ITN 88
Cdd:MTH00196   2 VALGILCLISSSNWLSVYLAIELQTLSLfILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCALLCGTTGGLHlsyINL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  89 MCNQLISFS----------IILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINpnILLLIT 158
Cdd:MTH00196  82 VLNSGQSFSsvsvpigyllIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVN--ILLIGG 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 159 TLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMM------------AILMYcpsmttlnLLIYLMLTIAMFTMLNINTSTT 226
Cdd:MTH00196 160 LFSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLwgieigsfesiqASLVY--------LFIYIIMSICVFSIILALNVYK 231

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 529217266 227 TL--ALSNLWNKTPTMTITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLI 297
Cdd:MTH00196 232 NLiiEFSGLSRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRIV 304
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 9-297 9.45e-20

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 89.62  E-value: 9.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266    9 IMLTIFMGTTLTMISSHWLLMWIGLEINMLAI-IPILMEKANPRSTEAATKYFLTQATASMLLMFTIvtnAMYSGQWGIT 87
Cdd:TIGR01770 107 LLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGI---SLIYGFTGSL 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   88 NMCNQLISFS---------------IILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSI--- 149
Cdd:TIGR01770 184 NFEDLLLFLSngmlnisllllgivlILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfg 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  150 ----NPNILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYLML----TIAMFTML-- 219
Cdd:TIGR01770 264 fseaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIyalmSLGAFGVLsl 343

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  220 ----NINTSTTTLALSNLWNKTPTMTITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLR 295
Cdd:TIGR01770 344 lrsyKDEWIEYISDFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLR 423


                  ..
gi 529217266  296 LI 297
Cdd:TIGR01770 424 VV 425
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 9-298 1.86e-19

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 89.02  E-value: 1.86e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   9 IMLTIFMGTTLTMISSHWLLMWIGLEINMLAI-IPILMEKANPRSTEAATKYFLTQATASMLLMFTIvtnAMYSGQWGIT 87
Cdd:COG1007  107 LLLFATLGMMLMASANDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSGFLLYGI---SLLYGATGSL 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  88 N------------MCNQLISFSIIL---ALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPN 152
Cdd:COG1007  184 NlagiaaalaaggANSPLLLLGLVLvlaGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAALLRLLVEAFPG 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 153 -------ILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMycpSMTTLN-------LLIYLMLTIAMFTM 218
Cdd:COG1007  264 laadwqlLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLA---AGTPLGvsaalfyLLAYLFMNLGAFAV 340

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 219 LNI----NTSTTTLA-LSNLWNKTPTMTITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFY 293
Cdd:COG1007  341 ILLlsrkGGEAEEIEdLAGLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYY 420


                 ....*
gi 529217266 294 LRLIY 298
Cdd:COG1007  421 LRVVK 425
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
21-297 3.18e-16

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 79.48  E-value: 3.18e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  21 MISS-HWLLMWIGLEINMLAI-IPILMEKANPRSTEAATKYFLTQATASMLLMFTIvtnAMYSGQWGITN---------- 88
Cdd:PRK05777 119 MVSAnDLLTLFLGLELLSLPLyALAALRRDRRRSLEAAIKYFVLGALASGFLLYGM---SLLYGATGSLSfagiakalad 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  89 --MCNQLISFSIIL---ALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQI-------YPSINPNILLL 156
Cdd:PRK05777 196 gsGNSLLLLFGLVFllvGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLlvvafggLSEDWQQVLAI 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 157 ITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMM------------AILMYcpsmttlnLLIYLMLTIAMFTMLNI--- 221
Cdd:PRK05777 276 IAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLvglaagtaegysAVLFY--------LLAYLFMTLGAFGVISLlrr 347

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 529217266 222 -NTSTTTLA-LSNLWNKTPTMTITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLI 297
Cdd:PRK05777 348 kGGEAESISdFAGLSKRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRVI 425
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 9-219 2.08e-12

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 67.96  E-value: 2.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   9 IMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRST---------EAATKYFLTQATASMLLMFTIvtnAM 79
Cdd:MTH00198 193 LVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGC---AL 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  80 YSGQWGITNMCNQLISFS-----------------IILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIM 142
Cdd:MTH00198 270 YFGFTGNEGMLGTILSATlettnielrqgslgylfITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILL 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 143 LQIYpsINPNILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWmmaILMYCPSMTTLNL-------LIYLMLTIAM 215
Cdd:MTH00198 350 TSLV--ITSKLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGF---ILIGVSAGTYESLqaswtyaVTYLVSALAS 424


                 ....
gi 529217266 216 FTML 219
Cdd:MTH00198 425 FTVI 428
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 8-301 5.62e-11

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 63.24  E-value: 5.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   8 PIMLTIFMGTTLTMISSHWLLMWIGLEINMLAIIPILMEKANPRSTEAATKYFLTQATASMLLMFTIVTNAMYSGQWGIT 87
Cdd:COG0651  111 PLFLLLLAGMNGAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMA 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  88 NMCNQLISFS----------IILALTMKLGMTPFHFWVPEV-----TQGISLMSGMLLltwqKLAPISIM---LQIYPSI 149
Cdd:COG0651  191 DLAARLAELDpglllaafalLLVGFGIKAALFPLHFWLPDAypaapSPVSALLSGLLT----KVGVYAILrvlTLLFGAD 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 150 NPN----ILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILMYCPSMTTLNLLIYL---MLTIAMFTML--N 220
Cdd:COG0651  267 PALflgtLLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLlnhALAKALLFLAagA 346

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 221 INTSTTTLALSNLWNKTPTMTITILISLLSLGGLP---PLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLI 297
Cdd:COG0651  347 IERATGTRDLDKLGGLGKRMPLTAAAFLIGALALAglpPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRIF 426


                 ....
gi 529217266 298 YSTS 301
Cdd:COG0651  427 GRAQ 430
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 291-341 1.05e-09

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 53.42  E-value: 1.05e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 529217266  291 YFYLRLIYSTSLTMFPTLNNLKMKWQFQQTKQMFLLPPLIILTTLTLPLSP 341
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKNTLLLPTLTTLSILLLPLTP 51
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
9-263 2.02e-08

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 55.44  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   9 IMLTIFMGTTLTMISSHWLLMWIGLEinMLAIIPILME---KANPRSTEAATKYFLTQATASMLLMFTI-VTNAMYSGQW 84
Cdd:PRK02504 115 ILLTATLGGMFLSGATELVMIFISLE--TLSIASYLLTgymKRDPRSNEAALKYLLIGAASSAIFLYGSsLLYGLSGGST 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  85 GITNMCNQLI---SFSIILALTM-------KLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLA----PISIMLQIYPSIN 150
Cdd:PRK02504 193 QLSAIALALItspSLGLALALVFviagiafKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAgfalAIRLLVTAFPSFD 272

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 151 PNILLLITTLSIM---VGGWGGLNQTQLRKIMAYSSIAHMGWMMaILMYCP-----SMTTLNLLIYLMLTIAMFT---ML 219
Cdd:PRK02504 273 EQWKLLFTALAILsmvLGNVVALAQTSMKRMLAYSSIGQAGFVM-IGLVAGteagyASMVFYLLAYLFMNLGAFAcviLF 351

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 529217266 220 NINTSTTTLA-LSNLWNKTPTMTITILISLLSLGGLPPLTGFLPK 263
Cdd:PRK02504 352 SLRTGTDQISdYAGLYQKDPLLTLGLSLCLLSLGGIPPLAGFFGK 396
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 55-191 6.07e-07

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 50.71  E-value: 6.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266   55 AATKYFLTQATASMLLMFTIVTNAMYSGQ-WGITNMCNQLISFS--------IILALTMKLGMTPFHFWVPEV-----TQ 120
Cdd:TIGR01972 157 AAMKFFLYTLAGSLLMLLAILGLYFLGGGtFDLLELLNLPLPFGvqtwlflaFFIAFAVKVPLFPLHTWLPDAhveapTA 236

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 529217266  121 GISLMSGMLLltwqKLAPISIM---LQIYPS---INPNILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMM 191
Cdd:TIGR01972 237 GSVILAGVLL----KMGTYGFLrfnLPLFPDaslYFAPVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFVL 309
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 55-192 1.17e-06

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 50.08  E-value: 1.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  55 AATKYFLTQATASMLLMFTIVTNAMYSGQW--GITNMCNQLISFS--------IILALTMKLGMTPFHFWVPEV-----T 119
Cdd:COG1008  162 AAIKFFLYTLAGSLLMLVAILALYFLAGALtfDIAELAAAPLPLTaqlllflaFFIAFAVKVPMFPFHTWLPDAhveapT 241

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 529217266 120 QGISLMSGMLLltwqKLAP---ISIMLQIYP---SINPNILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMA 192
Cdd:COG1008  242 AGSVLLAGVLL----KMGGyglLRFALPLFPeasAYFAPLLAALGVIGIIYGALVALAQTDLKRLIAYSSVSHMGFVLL 316
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 54-299 1.39e-05

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 46.63  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  54 EAATKYFLTQATASMLLMFTIvtnAMYSGQWGITNMCNQLISFS-------------IILALTMKLGMTPFHFWVPEV-T 119
Cdd:PRK08376 172 EAGIKYMFVGSLASSMVLLGI---ALLYGQYGTLNMAYLAVKMSenptvvakialalFIAGLAMKSGAVPVHMWLPDAyP 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 120 QGISLMSGMLLLTWQK--LAPISIMLQIY-PSINPN----ILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMM- 191
Cdd:PRK08376 249 AAPSSISAMLLVIKQAglYALARVLFSIYgPAINLAtvgwVIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGYMLl 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 192 ----------AILMYCPSMTTLNLLIYLMLTIAMFTMLNINTSTTTL---------ALSNLWNKTPTMTITILISLLSLG 252
Cdd:PRK08376 329 glgvglaalgDPAMASYGEIALAGGIYHIVNHALYKALLFLTAGAVIyetgtrnlnELGGLARTMPKTTIAFLIGAAAIV 408

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 529217266 253 GLPPLTGFLPKWIIAQELTKNNNIMLATTMtILALLNLYFYLRLIYS 299
Cdd:PRK08376 409 GLPPFNGFASKWLIYESSALFNPILGVIAM-IGSVLTLASFVKVFHT 454
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 55-222 4.91e-05

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 45.02  E-value: 4.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  55 AATKYFLTQATASMLLMFTIVTNAMYSGqwGITNMCNQLISFSIILALTM------------KLGMTPFHFWVP----EV 118
Cdd:PRK12561 138 AATKFILYTALASIFILVAGLALALSGD--TFTFDLAELGAKSYPLALELllyagfliafgvKLPIFPLHTWLPdahgEA 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 119 TQGISLMSGMLLLTWQKLAPISIMLQIYPSIN---PNILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGwmmailm 195
Cdd:PRK12561 216 SAPVSMILAGVLLKMGGYALIRFNVQMLPDAHvyfAPALAILGVVNIIYGALNAFAQDNVKRRLAYSSVSHMG------- 288

                        170       180
                 ....*....|....*....|....*..
gi 529217266 196 ycpsmttlnlliYLMLTIAMFTMLNIN 222
Cdd:PRK12561 289 ------------FVLLGIAAFTDLGIS 303
ND5 MTH00207
NADH dehydrogenase subunit 5; Provisional
 82-286 7.86e-05

NADH dehydrogenase subunit 5; Provisional


Pssm-ID: 164753 [Multi-domain]  Cd Length: 572  Bit Score: 44.37  E-value: 7.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  82 GQWGITNM----CNQLISFSIILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINP-----N 152
Cdd:MTH00207 165 GHWSITNMwqtdMNNYIALSIMIAAMTKSAQMPFSSWLPAAMAAPTPVSALVHSSTLVTAGVFLLIRFYPFLSStywfnP 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 153 ILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMMAILmycpSMTTLNLLIYLMLTIAMF---------TMLNINT 223
Cdd:MTH00207 245 ALLLTASLTMLMAGLSAMTECDMKKIIALSTLSQLGVMMASL----GLGMPKLALFHLITHALFkallfvcagSLIHSHH 320

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 529217266 224 STTTL-ALSNLWNKTPTMTITILISLLSLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILA 286
Cdd:MTH00207 321 HSQDLrTMGNLTNQMPLTTSCLLIANLALCGSPFLSGFYSKDLILESSLFYPHNSLMILMIFLA 384
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 55-191 1.06e-04

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 44.04  E-value: 1.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  55 AATKYFLTQATASMLLMFTI----VTNAMYSGQWGITNMCN--------QLISFSIILALTMKLGMTPFHFWVPEV---- 118
Cdd:PRK05846 162 AATKFFLYTLLGSLLMLVAIiylvVVYYNATGTFDIADLLNlplppgvqYWLFLAFFIAFAVKMPMFPLHTWLPDAhvqa 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 119 -TQGISLMSGMLLltwqKLAP---ISIMLQIYPSINPNILLLITTLSIMV---GGWGGLNQTQLRKIMAYSSIAHMGWMM 191
Cdd:PRK05846 242 pTAGSVLLAGILL----KMGAyglLRFSLPLFPDASHEFAPIIITLGVIAiiyGALVALAQTDIKKLIAYSSISHMGFVT 317
ndhB CHL00049
NADH dehydrogenase subunit 2
 47-297 2.40e-04

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 42.68  E-value: 2.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  47 KANPRSTEAATKYFLTQATASMLLMFTIVTNAMYSGQ----WGI------TNMCNQLISF----SIILALTMKLGMTPFH 112
Cdd:CHL00049 155 KKDVRSNEATMKYLLMGGASSSILVYGFSWLYGLSGGeielQEIvnglinTQMYNSPGISialiFITVGIGFKLSLAPFH 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 113 FWVPEVTQG-----------ISLMSGMLLLTwqklapiSIMLQIYPSINP---NILLLITTLSIMVGGWGGLNQTQLRKI 178
Cdd:CHL00049 235 QWTPDVYEGsptpvvaflsvTSKVAASALAT-------RIFDIPFYFSSNewhLLLEILAILSMILGNLIAITQTSMKRM 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 179 MAYSSIAHMGWMM-AILMYCPSMTTLNLLIYLMLTIAM-------FTMLNINTSTTTLA-LSNLWNKTPTMTITILISLL 249
Cdd:CHL00049 308 LAYSSIGQIGYVIiGIIVGDSNDGYASMITYMLFYIFMnlgtfacIVLFGLRTGTDNIRdYAGLYTKDPFLALSLALCLL 387

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 529217266 250 SLGGLPPLTGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLI 297
Cdd:CHL00049 388 SLGGIPPLAGFFGKLYLFWCGWQAGLYFLVSIGLLTSVISIYYYLKII 435
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 17-191 3.52e-04

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 42.43  E-value: 3.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  17 TTLTMISSHWLLMWIGLEINML---AIIPILMEKANprsTEAATKYFLTQATA------SMLLMFTIVTNAMYSGQWGIT 87
Cdd:PRK08676 115 ITFAFFSDNLALFWIFAELTTVfsaMLIAILSAREN---IDAALKYIFIASTAmifafiGLIFLFSLTRQALGTGTLNWT 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  88 NMCNQ---------LISFSIIL-ALTMKLGMTPFHFWVPEV-TQGISLMSGMLLLTWQKLAPISImLQIYP--------S 148
Cdd:PRK08676 192 ELAAHasllspsvlGASFLFIFiGFLAKSGLVPFHTWLPAAyAKAPSVVSALLSGTVLNIGIYGI-LRLSAllrqsgaaE 270

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 529217266 149 INPNILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMM 191
Cdd:PRK08676 271 QFSNVLIGLGIFSIAVAAFSMLSQRNLKKLIAFSSIEHMGLML 313
PRK07363 PRK07363
NADH-quinone oxidoreductase subunit M;
98-206 4.82e-04

NADH-quinone oxidoreductase subunit M;


Pssm-ID: 180945 [Multi-domain]  Cd Length: 501  Bit Score: 42.01  E-value: 4.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  98 IILALTMKLGMTPFHFWVP----EVTQGISLMSGMLLLTWQKLAPISIMLQIYP---SINPNILLLITTLSIMVGGWGGL 170
Cdd:PRK07363 211 LLLGFGIKIPLVPLHTWLPdaytEASPAVAILLGGVLAKLGTYGLLRFGLQLFPqtwSLVAPGLAIIGTISVIYGALSAI 290

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 529217266 171 NQTQLRKIMAYSSIAHMGWmmaILMYCPSMTTLNLL 206
Cdd:PRK07363 291 AQKDIKRMVAYSSIGHMGY---ILVAAAAGTQLSLL 323
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 93-211 8.45e-04

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 41.19  E-value: 8.45e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  93 LISFSIILALTMKLGMTPFHFWVPEV-----TQGISLMSGMLLltwqKLAP---ISIMLQIYPSINPNILLLITTLSIMV 164
Cdd:MTH00217 207 FIFLGFFLSLAIKIPKIPFHIWLPQAhveapVAGSVILAGVLL----KLGGygfIRFSWPLLPEASEYFSPLIQTLSLLA 282

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 529217266 165 GGWGGLN---QTQLRKIMAYSSIAHMGwMMAILMYCPSMTTLNLLIYLML 211
Cdd:MTH00217 283 IIYGSLTtcrQVDLKRIIAYSSVAHMG-LVTLGIFSHTIQGLVAAIFLML 331
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 94-219 1.90e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 39.90  E-value: 1.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  94 ISFSIILALTMKLGMTPFHFWVPEV-----TQGISLMSGMLL---------LTW-------QKLAPISIMLQIypsinpn 152
Cdd:MTH00226 232 IFLGIFLAMAVKIPIFPFHIWLPKAhveapVAGSVLLAGILLklggyglvrLSWpilplgaQNLAPAVIAMGI------- 304

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 529217266 153 illlittLSIMVGGWGGLNQTQLRKIMAYSSIAHMGwMMAILMYCPSMTTLNLLIYLMLTIAMFTML 219
Cdd:MTH00226 305 -------VGIVYGSFATCRQIDVKRLVAYSSVAHMG-LVSITLVTHDIIGLTGSIFIMLAHGIVSSL 363
PRK12650 PRK12650
DUF4040 family protein;
110-192 2.24e-03

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 40.03  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 110 PFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYP--SINP--NILLLITTL-SIMVGGWGGLNQTQLRKIMAYSSI 184
Cdd:PRK12650 226 PFHFWLPEAMAAITPVSAFLHAAAVVKAGIYLLLRFSPvfHDVAvwNWLLIIVGMiTALMGAVFAVQKTDLKKLTAYSTV 305


                 ....*...
gi 529217266 185 AHMGWMMA 192
Cdd:PRK12650 306 SQLGWIVA 313
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
 98-317 4.48e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 38.31  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  98 IILALTMKLGMTPFHFWVPEVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINPNILLLITTLSIMVggwgGLNQTQLRK 177
Cdd:MTH00091  63 QFLILMMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFFSKNFFFLLLFGLLICFFQ----MFLLKSYKN 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 178 IMAYSSIAHMGWMMAILMYCPSMTtlnLLIYLMLTIAMFTMLnintstttlalsNLWNKTPTMTITILISLLSLGGLPPL 257
Cdd:MTH00091 139 LLILSSTESFNWLILSFFFSFFNV---FFLFFYYFLLMLFLI------------PKFNNVNKLNFVSWETLLVFMNLPFS 203

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 258 TGFLPKWIIAQELTKNNNIMLATTMTILALLNLYFYLRLIYSTSLTMFPTLNNLKMKWQF 317
Cdd:MTH00091 204 VTFFVKIFSLSEILKVLGFFLLFLLFLMFLSVLSLSFWLVNLSTKLFLMLFKYNKGFFFF 263
ndhD CHL00011
NADH dehydrogenase subunit 4
 55-191 4.60e-03

NADH dehydrogenase subunit 4


Pssm-ID: 176954 [Multi-domain]  Cd Length: 498  Bit Score: 38.77  E-value: 4.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  55 AATKYFLTQATASMLLMFTIVTNAMYSGQ---WGITNMCNQ--------LISFSIILALTMKLGMTPFHFWVPEvTQGIS 123
Cdd:CHL00011 163 SATKFILYTAGGSIFLLIGVLGMGLYGSNeptLNFETLANQsypvaleiLFYIGFLIAYAVKLPIIPLHTWLPD-THGEA 241

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 529217266 124 LMSGMLLLTWQKL-----APISIMLQIYP---SINPNILLLITTLSIMVGGWGGLNQTQLRKIMAYSSIAHMGWMM 191
Cdd:CHL00011 242 HYSTCMLLAGILLkmgayGLIRINMELLPhahSIFSPWLVIVGAIQIIYAASTSLGQRNLKKRIAYSSVSHMGFII 317
ND4 MTH00204
NADH dehydrogenase subunit 4; Provisional
 55-211 4.79e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 164750 [Multi-domain]  Cd Length: 485  Bit Score: 38.51  E-value: 4.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  55 AATKYFLTQATASMLLMFTIVTNAMYSGQWGITNMCNQLISFSI--------ILALTMKLGMTPFHFWVPEV-----TQG 121
Cdd:MTH00204 164 ASYYFFFYTFAGSVFMLLGIFQLYSITGTTDYQILLNIKLPLSIqkwllvgfFLSLAVKIPQIPFHIWLPQAhveapVAG 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266 122 ISLMSGMLLltwqKLAP---ISIMLQIYPSINPNILLLITTLSIMVGGWGGL---NQTQLRKIMAYSSIAHMGwMMAILM 195
Cdd:MTH00204 244 SVILAGILL----KLGGygfLRFSWPLFPAASEYFAPLIVMLSVIAVIYGSLttcRQVDFKRLIAYSSVAHMG-LVPLGL 318

                        170
                 ....*....|....*.
gi 529217266 196 YCPSMTTLNLLIYLML 211
Cdd:MTH00204 319 FTHTIEGLVAAVFLML 334
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 98-191 5.94e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 38.32  E-value: 5.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 529217266  98 IILALTMKLGMTPFHFWVP----EVTQGISLMSGMLLLTWQKLAPISIMLQIYPSINP------NILLLITTLSIMVGGW 167
Cdd:PRK08375 208 VLLALALKAAVFPLHTWLPraypAAPPVVTALLSGLVTKVAVYALIRIYFTVFGGDFRfalglgWLLAVLALLSMLVGSL 287

                         90       100
                 ....*....|....*....|....
gi 529217266 168 GGLNQTQLRKIMAYSSIAHMGWMM 191
Cdd:PRK08375 288 AALGQDDVKRVLAYSTVSQMGYIL 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH