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Conserved domains on  [gi|745999858|ref|YP_009114664|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Megaladapis edwardsi]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 2.52e-71

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 212.74  E-value: 2.52e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858   1 MMYMMFGLSAMFVLGFMGFSSKPSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858  81 TWGSSAVIWGVLLLGVGMEMVVMVWVVNYGEMVGVIDFSSLEDWILFGSKEGSVVREDSLGVANLYDLTSWFAVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 745999858 161 FVSVLIIIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 2.52e-71

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 212.74  E-value: 2.52e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858   1 MMYMMFGLSAMFVLGFMGFSSKPSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858  81 TWGSSAVIWGVLLLGVGMEMVVMVWVVNYGEMVGVIDFSSLEDWILFGSKEGSVVREDSLGVANLYDLTSWFAVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 745999858 161 FVSVLIIIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-93 2.18e-07

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 47.50  E-value: 2.18e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 745999858   17 MGFSSKPSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAM-ATEEYPETWGSSAVIWGVLL 93
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLL 78
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 2.52e-71

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 212.74  E-value: 2.52e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858   1 MMYMMFGLSAMFVLGFMGFSSKPSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858  81 TWGSSAVIWGVLLLGVGMEMVVMVWVVNYGEMVGVIDFSSLEDWILFGSKEGSVVREDSLGVANLYDLTSWFAVVAGWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|..
gi 745999858 161 FVSVLIIIEIIR 172
Cdd:MTH00109 162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 5.96e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 115.24  E-value: 5.96e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858   1 MMYMMFGLSAMFVLGFMGFSSKPSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858  81 TWGSSAVIWGVLLLGVGMEMVVMVWVVNYGEMvgvidfssleDWILFGS-KEGSVVREDSLGVANLYDLTSWFAVVAGWS 159
Cdd:MTH00138  81 SWGSWSVLGYVVGYLVGVVLAAGLFWGGWYEG----------SWVVVDElKEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                        170
                 ....*....|...
gi 745999858 160 LFVSVLIIIEIIR 172
Cdd:MTH00138 151 LLLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 1.51e-28

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 103.77  E-value: 1.51e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858   1 MMYMMFGLSAMFVLGFMGFSSKPSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858  81 TWGSSAVIWGVLLLGVGMEMVVMVWVVNYgemvgvidfsSLEDWILFGSKEGSVVREDSLGVANLYDLTSWFAVVAGWSL 160
Cdd:MTH00065  81 AWGSWSVLVYVLFYLLLLIVGYILFGCNF----------SLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|..
gi 745999858 161 FVSVLIIIEIIR 172
Cdd:MTH00065 151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 5.89e-26

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 97.13  E-value: 5.89e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858   1 MMYMMFGLSAMFVLGFMGFSSKPSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858  81 TWGSSAVIWGVLLLGVGMEMvvmvwvvnYGEMVGVIDFSSLEDWILFGSKEGSVVREDSLGVANLYDLTSWFAVVAGWSL 160
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVV--------VGVVVGGLWGMEGVGVVTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|..
gi 745999858 161 FVSVLIIIEIIR 172
Cdd:MTH00115 153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 3.92e-15

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 68.86  E-value: 3.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858   1 MMYMMFGLSAMFVLGFMGFSSKPSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858  81 TWGSSAVIWGVLLLGVGmemvvmvwvvnygemVGVIDFSSLEDWILFGSKEGSVVRE-DSLGVANLYDLTSWFAVVAGWS 159
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLG---------------LGFVGFYFYGGWEMLSWMGVDEANNlDLSGVSDLYSRGFFLLLLGGVV 145

                        170
                 ....*....|...
gi 745999858 160 LFVSVLIIIEIIR 172
Cdd:MTH00214 146 LFLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 24-170 2.70e-09

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 53.37  E-value: 2.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999858  24 SPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAMATEEYPETWGSSAVIWGVLLLGVgmemvvm 103
Cdd:MTH00045  22 SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPSVSNLGEVLVLSLLLSL------- 94

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 745999858 104 vwvvnygeMVGVIDFSSLEDWILFGSkegSVVREDSLGVANLYDLTSWFAVVAGWSLFVSVLIIIEI 170
Cdd:MTH00045  95 --------WVFISFDNFLELSNNNWS---LVSLSDLVGSSELYNSGGLYLLLGGFILLVALVVALVI 150
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-93 2.18e-07

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 47.50  E-value: 2.18e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 745999858   17 MGFSSKPSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAM-ATEEYPETWGSSAVIWGVLL 93
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLL 78
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 2-78 2.48e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 42.30  E-value: 2.48e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 745999858   2 MYMMFGLSAMFVLGFMgFSSKPSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   1 MLLSLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00015
NADH dehydrogenase subunit 6; Validated
 2-73 7.25e-03

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 164590  Cd Length: 155  Bit Score: 35.22  E-value: 7.25e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 745999858   2 MYMMFGLSAMFVLGFMGFSSKpSPIYGGIGLIVSGALGCSIIMGFGGSFMGLMVFLVYLGGMLVVFGYTTAM 73
Cdd:MTH00015   1 MSLSFFLILMISLTCSLFLAT-TPITLGINILMMALLLATTMASALSSWFAFLTFLIYVGGMLVMFAYFLAL 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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