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Conserved domains on  [gi|745999886|ref|YP_009114690|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Palaeopropithecus ingens]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 8.16e-79

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 231.61  E-value: 8.16e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886   1 MTYIAFLLSVVLVLGFMSFSSKPSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886  81 TWGSSVVIWGALLLGVVMELLVVVWMVGYDGLGVVVDFGNLENWVIFMDEGVDVIREDSMGVAALYDYTSWFIMVAAWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 745999886 161 FVSILIVIEVIRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 8.16e-79

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 231.61  E-value: 8.16e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886   1 MTYIAFLLSVVLVLGFMSFSSKPSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886  81 TWGSSVVIWGALLLGVVMELLVVVWMVGYDGLGVVVDFGNLENWVIFMDEGVDVIREDSMGVAALYDYTSWFIMVAAWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 745999886 161 FVSILIVIEVIRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-169 1.01e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 54.05  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886   21 SKPSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSVVIWGALLLGVVMeL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-L 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 745999886  101 LVVVWMVGYDGLGVVVDfgnlenwvifmDEGVDVIREDSMGVAALYDYtSWFIMVAAWSLFVSILIVIE 169
Cdd:pfam00499  84 ALLLLVLLSASLTPAAA-----------AAAPDVGNIEAIGELLFTDY-LLPFELASVLLLVALVGAIV 140
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-173 8.16e-79

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 231.61  E-value: 8.16e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886   1 MTYIAFLLSVVLVLGFMSFSSKPSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109   2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886  81 TWGSSVVIWGALLLGVVMELLVVVWMVGYDGLGVVVDFGNLENWVIFMDEGVDVIREDSMGVAALYDYTSWFIMVAAWSL 160
Cdd:MTH00109  82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                        170
                 ....*....|...
gi 745999886 161 FVSILIVIEVIRG 173
Cdd:MTH00109 162 FIGVFVIIEITRG 174
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-173 1.07e-36

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 124.87  E-value: 1.07e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886   1 MTYIAFLLSVVLVLGFMSFSSKPSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886  81 TWGS-SVVIWGALLLGVVMELLVVVWMVGYDGLGVVVDFGnlenwvifmdEGVDVIREDSMGVAALYDYTSWFIMVAAWS 159
Cdd:MTH00138  81 SWGSwSVLGYVVGYLVGVVLAAGLFWGGWYEGSWVVVDEL----------KEFSVLRGDVGGVALMYSSGGGMLVICAWV 150

                        170
                 ....*....|....
gi 745999886 160 LFVSILIVIEVIRG 173
Cdd:MTH00138 151 LLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 4.84e-31

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 110.32  E-value: 4.84e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886   1 MTYIAFLLSVVLVLGFMSFSSKPSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886  81 TWGSSVVIWgalLLGVVMELLVVVWMvgydglgVVVDFGNLENWVIFMDEGVDVIREDSMGVAALYDYTSWFIMVAAWSL 160
Cdd:MTH00065  81 AWGSWSVLV---YVLFYLLLLIVGYI-------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                        170
                 ....*....|...
gi 745999886 161 FVSILIVIEVIRG 173
Cdd:MTH00065 151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-173 3.28e-25

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 95.20  E-value: 3.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886   1 MTYIAFLLSVVLVLGFMSFSSKPSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886  81 TWGSSVVIWGALLLGVVMELLVVVWMVGYDGLGVVVdfgnlenwVIFMDEGVDVIREDSMGVAALYDYTSWFIMVAAWSL 160
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGV--------VTVDSGGLFVVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                        170
                 ....*....|...
gi 745999886 161 FVSILIVIEVIRG 173
Cdd:MTH00115 153 LLTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-173 1.06e-14

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 67.71  E-value: 1.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886   1 MTYIAFLLSVVLVLGFMSFSSKPSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886  81 TWGSSVVIWGALLLGVvmellvvvwmvgydGLGVVVDFGNLENWVIFMDEGVDVIREDSMGVAALYDYTSWFIMVAAWSL 160
Cdd:MTH00214  81 SWGGWSVLLFFLFYLL--------------GLGFVGFYFYGGWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                        170
                 ....*....|...
gi 745999886 161 FVSILIVIEVIRG 173
Cdd:MTH00214 147 FLVLFVVLELVRG 159
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-169 1.01e-09

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 54.05  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886   21 SKPSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSVVIWGALLLGVVMeL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLL-L 83

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 745999886  101 LVVVWMVGYDGLGVVVDfgnlenwvifmDEGVDVIREDSMGVAALYDYtSWFIMVAAWSLFVSILIVIE 169
Cdd:pfam00499  84 ALLLLVLLSASLTPAAA-----------AAAPDVGNIEAIGELLFTDY-LLPFELASVLLLVALVGAIV 140
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 24-173 1.67e-09

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 53.76  E-value: 1.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 745999886  24 SPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEYPETWGSSVVIwgalllgvVMELLVV 103
Cdd:MTH00045  22 SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPSVSNLGEVL--------VLSLLLS 93

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 745999886 104 VWMvgydglgvvvdFGNLENWVIFMDEGVDVIR-EDSMGVAALYDYTSWFIMVAAWSLFVSILIVIEVIRG 173
Cdd:MTH00045  94 LWV-----------FISFDNFLELSNNNWSLVSlSDLVGSSELYNSGGLYLLLGGFILLVALVVALVISFG 153
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 7-78 1.76e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 39.99  E-value: 1.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 745999886   7 LLSVVLVLGFMsFSSKPSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212   6 LLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 6-74 6.49e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 35.63  E-value: 6.49e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 745999886   6 FLLSVVLVLGFMSFSSKpSPVYGGVGLVVSGAMGCGIIVSFGGSFVGLMVFLIYLGGMLVVFGYTTAMA 74
Cdd:MTH00152   5 ILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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