NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|849254200|ref|YP_009150276|]
View 

DnaB-like replicative helicase [Propionibacterium phage PHL116M00]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RAD55 super family cl33894
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
35-199 6.21e-06

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0467:

Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 46.45  E-value: 6.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 849254200  35 IHKGDLVMIAGRSGSQKSGLAM-FITAML--NQPALYISgdmtpweastriislnTQHTTAQIQHNIDDYG--PEYYRDS 109
Cdd:COG0467   17 LPRGSSTLLSGPPGTGKTTLALqFLAEGLrrGEKGLYVS----------------FEESPEQLLRRAESLGldLEEYIES 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 849254200 110 ihhgEHITFSFQSPI----TWTDITMELQAYMEMWNtfPPIIVIDNLMDIQDCESDYQAQQEAMQWITALGRDTGSTIIV 185
Cdd:COG0467   81 ----GLLRIIDLSPEelglDLEELLARLREAVEEFG--AKRVVIDSLSGLLLALPDPERLREFLHRLLRYLKKRGVTTLL 154

                        170
                 ....*....|....*...
gi 849254200 186 THH----ATDKTGSDIEH 199
Cdd:COG0467  155 TSEtgglEDEATEGGLSY 172
 
Name Accession Description Interval E-value
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
35-199 6.21e-06

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 46.45  E-value: 6.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 849254200  35 IHKGDLVMIAGRSGSQKSGLAM-FITAML--NQPALYISgdmtpweastriislnTQHTTAQIQHNIDDYG--PEYYRDS 109
Cdd:COG0467   17 LPRGSSTLLSGPPGTGKTTLALqFLAEGLrrGEKGLYVS----------------FEESPEQLLRRAESLGldLEEYIES 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 849254200 110 ihhgEHITFSFQSPI----TWTDITMELQAYMEMWNtfPPIIVIDNLMDIQDCESDYQAQQEAMQWITALGRDTGSTIIV 185
Cdd:COG0467   81 ----GLLRIIDLSPEelglDLEELLARLREAVEEFG--AKRVVIDSLSGLLLALPDPERLREFLHRLLRYLKKRGVTTLL 154

                        170
                 ....*....|....*...
gi 849254200 186 THH----ATDKTGSDIEH 199
Cdd:COG0467  155 TSEtgglEDEATEGGLSY 172
ABCC_MRP_domain1 cd03250
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ...
 25-111 7.04e-04

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.


Pssm-ID: 213217 [Multi-domain]  Cd Length: 204  Bit Score: 40.15  E-value: 7.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 849254200  25 EPLYRNLDMHIHKGDLVMIAGRSGSQKSGLAMfitAML-----NQPALYISGDM-----TPWeastriislnTQHTTaqI 94
Cdd:cd03250   18 SFTLKDINLEVPKGELVAIVGPVGSGKSSLLS---ALLgelekLSGSVSVPGSIayvsqEPW----------IQNGT--I 82

                         90       100
                 ....*....|....*....|
gi 849254200  95 QHNI---DDYGPEYYRDSIH 111
Cdd:cd03250   83 RENIlfgKPFDEERYEKVIK 102
PRK10522 PRK10522
multidrug transporter membrane component/ATP-binding component; Provisional
 31-72 3.72e-03

multidrug transporter membrane component/ATP-binding component; Provisional


Pssm-ID: 236707 [Multi-domain]  Cd Length: 547  Bit Score: 38.80  E-value: 3.72e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 849254200  31 LDMHIHKGDLVMIAGRSGSQKSGLAMFITAmLNQPAlyiSGD 72
Cdd:PRK10522 342 INLTIKRGELLFLIGGNGSGKSTLAMLLTG-LYQPQ---SGE 379
 
Name Accession Description Interval E-value
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
35-199 6.21e-06

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 46.45  E-value: 6.21e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 849254200  35 IHKGDLVMIAGRSGSQKSGLAM-FITAML--NQPALYISgdmtpweastriislnTQHTTAQIQHNIDDYG--PEYYRDS 109
Cdd:COG0467   17 LPRGSSTLLSGPPGTGKTTLALqFLAEGLrrGEKGLYVS----------------FEESPEQLLRRAESLGldLEEYIES 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 849254200 110 ihhgEHITFSFQSPI----TWTDITMELQAYMEMWNtfPPIIVIDNLMDIQDCESDYQAQQEAMQWITALGRDTGSTIIV 185
Cdd:COG0467   81 ----GLLRIIDLSPEelglDLEELLARLREAVEEFG--AKRVVIDSLSGLLLALPDPERLREFLHRLLRYLKKRGVTTLL 154

                        170
                 ....*....|....*...
gi 849254200 186 THH----ATDKTGSDIEH 199
Cdd:COG0467  155 TSEtgglEDEATEGGLSY 172
ABCC_MRP_domain1 cd03250
ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This ...
 25-111 7.04e-04

ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C; This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.


Pssm-ID: 213217 [Multi-domain]  Cd Length: 204  Bit Score: 40.15  E-value: 7.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 849254200  25 EPLYRNLDMHIHKGDLVMIAGRSGSQKSGLAMfitAML-----NQPALYISGDM-----TPWeastriislnTQHTTaqI 94
Cdd:cd03250   18 SFTLKDINLEVPKGELVAIVGPVGSGKSSLLS---ALLgelekLSGSVSVPGSIayvsqEPW----------IQNGT--I 82

                         90       100
                 ....*....|....*....|
gi 849254200  95 QHNI---DDYGPEYYRDSIH 111
Cdd:cd03250   83 RENIlfgKPFDEERYEKVIK 102
PRK10522 PRK10522
multidrug transporter membrane component/ATP-binding component; Provisional
 31-72 3.72e-03

multidrug transporter membrane component/ATP-binding component; Provisional


Pssm-ID: 236707 [Multi-domain]  Cd Length: 547  Bit Score: 38.80  E-value: 3.72e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 849254200  31 LDMHIHKGDLVMIAGRSGSQKSGLAMFITAmLNQPAlyiSGD 72
Cdd:PRK10522 342 INLTIKRGELLFLIGGNGSGKSTLAMLLTG-LYQPQ---SGE 379
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH