Putative viral replication protein; This is a family of viral ORFs from various plant and animal ssDNA circoviruses. Published evidence to support the annotated function "viral replication associated protein" has not be found.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922073303    3 SKRWCYTLNNYSEDDVVTMKAvPTTYHVLGKEVGTNGTPHIQGFLTFKSNKRLSAMKKI-NARAHWEVAKGTSKQAADYC 81
Cdd:pfam02407   1 ARCWCFTLNNPTEFLSLFSQD-ELKYFVYQDERGTTGTKHLQGFVEFKNRTSLGQMKKKfPGRAHLEIARGSQEEARDYC 79

                  ...
gi 922073303   82 KKD 84
Cdd:pfam02407  80 MKE 82

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 922073303 131 KGLSALKSLLSESRETDDVRGIWLHGPPGCGKSHLARTV 169
Cdd:cd00009    1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAI 39

Putative viral replication protein; This is a family of viral ORFs from various plant and animal ssDNA circoviruses. Published evidence to support the annotated function "viral replication associated protein" has not be found.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922073303    3 SKRWCYTLNNYSEDDVVTMKAvPTTYHVLGKEVGTNGTPHIQGFLTFKSNKRLSAMKKI-NARAHWEVAKGTSKQAADYC 81
Cdd:pfam02407   1 ARCWCFTLNNPTEFLSLFSQD-ELKYFVYQDERGTTGTKHLQGFVEFKNRTSLGQMKKKfPGRAHLEIARGSQEEARDYC 79

                  ...
gi 922073303   82 KKD 84
Cdd:pfam02407  80 MKE 82

hypothetical protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922073303   8 YTLNNYSEDDVVTMKAVPTTYHVLGKEVgTNGTPHIQGFLTFKSNKRLSAMKKINARAHWEVAKGT-------SKQAADY 80
Cdd:PHA02969   8 FILNDYSDDDYKKIKSIDCHHIIIDKES-DDSHKIISGYIELKDGALCSIIENINPNIIYEILKDNcdfdiikKKNIVDS 86

                 ....*....
gi 922073303  81 CKKDGNFEE 89
Cdd:PHA02969  87 FKSKGCYEE 95

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];

                         10        20
                 ....*....|....*....|....*.
gi 922073303 150 RGIWLHGPPGCGKSHLARTVSPYLKA 175
Cdd:COG1222  113 KGVLLYGPPGTGKTLLAKAVAGELGA 138

Predicted ATPase, AAA+ superfamily [General function prediction only];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922073303 126 VIKYHKGLSALKSLLSESRetddvRGIWLHGPPGCGKSHLARTVS-----PYLK--------------AQN--KWWDgYA 184
Cdd:COG1223   17 IIKELRRRENLRKFGLWPP-----RKILFYGPPGTGKTMLAEALAgelklPLLTvrldsligsylgetARNlrKLFD-FA 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922073303 185 NEE--YVLIDDFDKGGKCLGhYLKLwadkyecTGEIKGATVAL-------NHRKFIITSNYHPdEIFDddsvllEAITRR 255
Cdd:COG1223   91 RRApcVIFFDEFDAIAKDRG-DQND-------VGEVKRVVNALlqeldglPSGSVVIAATNHP-ELLD------SALWRR 155

                 ....
gi 922073303 256 FSIR 259
Cdd:COG1223  156 FDEV 159

Putative viral replication protein; This is a family of viral ORFs from various plant and animal ssDNA circoviruses. Published evidence to support the annotated function "viral replication associated protein" has not be found.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922073303    3 SKRWCYTLNNYSEDDVVTMKAvPTTYHVLGKEVGTNGTPHIQGFLTFKSNKRLSAMKKI-NARAHWEVAKGTSKQAADYC 81
Cdd:pfam02407   1 ARCWCFTLNNPTEFLSLFSQD-ELKYFVYQDERGTTGTKHLQGFVEFKNRTSLGQMKKKfPGRAHLEIARGSQEEARDYC 79

                  ...
gi 922073303   82 KKD 84
Cdd:pfam02407  80 MKE 82

hypothetical protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922073303   8 YTLNNYSEDDVVTMKAVPTTYHVLGKEVgTNGTPHIQGFLTFKSNKRLSAMKKINARAHWEVAKGT-------SKQAADY 80
Cdd:PHA02969   8 FILNDYSDDDYKKIKSIDCHHIIIDKES-DDSHKIISGYIELKDGALCSIIENINPNIIYEILKDNcdfdiikKKNIVDS 86

                 ....*....
gi 922073303  81 CKKDGNFEE 89
Cdd:PHA02969  87 FKSKGCYEE 95

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

                         10        20
                 ....*....|....*....|....*
gi 922073303 150 RGIWLHGPPGCGKSHLARTVSPYLK 174
Cdd:cd19518   35 RGVLLHGPPGCGKTMLANAIAGELK 59

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.

                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 922073303 131 KGLSALKSLLSESRETDDVRGIWLHGPPGCGKSHLARTV 169
Cdd:cd00009    1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAI 39

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 922073303  133 LSALKSLLSESREtDDVRGIWLHGPPGCGKSHLARTVSPYLKAQNKWW 180
Cdd:pfam13191   9 LEQLLDALDRVRS-GRPPSVLLTGEAGTGKTTLLRELLRALERDGGYF 55

cell division protein CdvC;

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 922073303  98 KR-TDLEDAAVMITAGESLKR------VAEEHPTVVIKYHKGLSALKSLLSE-----SRETDDV-----RGIWLHGPPGC 160
Cdd:NF041006  66 KRiEVLEELVPAEPAGPDVEKesdeelVVKEKPKVTFSDIVGLEDVKEALKEaivypSKRPDLFplgwpRGILLYGPPGC 145

                         90
                 ....*....|
gi 922073303 161 GKSHLARTVS 170
Cdd:NF041006 146 GKTMLAAAVA 155

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

                         10        20        30
                 ....*....|....*....|....*....|....
gi 922073303 137 KSLLSESRETDDVRGIWLHGPPGCGKSHLARTVS 170
Cdd:cd19520   23 PELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATA 56

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

                         10        20
                 ....*....|....*....|.
gi 922073303 149 VRGIWLHGPPGCGKSHLARTV 169
Cdd:cd19509   32 PRGILLYGPPGTGKTLLARAV 52

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.

                         10        20
                 ....*....|....*....|
gi 922073303 151 GIWLHGPPGCGKSHLARTVS 170
Cdd:cd19526   29 GILLYGPPGCGKTLLASAIA 48