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Conserved domains on  [gi|1060285632|ref|YP_009272866|]
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hypothetical protein BGV91_gp46 [Haloarcula californiae icosahedral virus 1]

Protein Classification

PhlB family protein( domain architecture ID 1001839)

PhlB family protein contains a C-terminal OB-fold domain and a zinc-ribbon domain, similar to the PhlB subunit of 2,4-diacetylphloroglucinol biosynthesis protein, a bacterial Friedel-Crafts acylase; PhlB may not be involved in the catalytic mechanism but may instead be required to form the dodecameric enzyme complex

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG1545 super family cl34302
Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];
6-37 1.84e-04

Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];


The actual alignment was detected with superfamily member COG1545:

Pssm-ID: 441154 [Multi-domain]  Cd Length: 116  Bit Score: 34.87  E-value: 1.84e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1060285632   6 RCQGCGHVQSPPGAFvfnCPRCQGTN--WTPADG 37
Cdd:COG1545    14 RCPACGTVYFPPRPV---CPHCGSEDleWVELSG 44
 
Name Accession Description Interval E-value
COG1545 COG1545
Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];
6-37 1.84e-04

Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 441154 [Multi-domain]  Cd Length: 116  Bit Score: 34.87  E-value: 1.84e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1060285632   6 RCQGCGHVQSPPGAFvfnCPRCQGTN--WTPADG 37
Cdd:COG1545    14 RCPACGTVYFPPRPV---CPHCGSEDleWVELSG 44
HypA pfam01155
Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone ...
 6-37 5.11e-04

Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.


Pssm-ID: 460085  Cd Length: 111  Bit Score: 33.65  E-value: 5.11e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1060285632   6 RCQGCGHvQSPPGAFVFNCPRCQGTNWTPADG 37
Cdd:pfam01155  71 RCRDCGK-EFELEERDLVCPRCGSPDVEILSG 101
 
Name Accession Description Interval E-value
COG1545 COG1545
Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];
6-37 1.84e-04

Uncharacterized OB-fold protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 441154 [Multi-domain]  Cd Length: 116  Bit Score: 34.87  E-value: 1.84e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1060285632   6 RCQGCGHVQSPPGAFvfnCPRCQGTN--WTPADG 37
Cdd:COG1545    14 RCPACGTVYFPPRPV---CPHCGSEDleWVELSG 44
HypA pfam01155
Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone ...
 6-37 5.11e-04

Hydrogenase/urease nickel incorporation, metallochaperone, hypA; HypA is a metallochaperone that binds nickel to bring it safely to its target. The targets for Hypa are the nickel-containing enzymes [Ni,Fe]-hydrogenase and urease. The nickel coordinates with four nitrogens within the protein. The four conserved cysteines towards the C-terminus bind one zinc moiety probably to stabilize the protein fold.


Pssm-ID: 460085  Cd Length: 111  Bit Score: 33.65  E-value: 5.11e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1060285632   6 RCQGCGHvQSPPGAFVFNCPRCQGTNWTPADG 37
Cdd:pfam01155  71 RCRDCGK-EFELEERDLVCPRCGSPDVEILSG 101
HybF COG0375
Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion ...
 6-37 1.11e-03

Hydrogenase maturation factor HypA/HybF, metallochaperone involved in Ni insertion [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440144  Cd Length: 113  Bit Score: 32.83  E-value: 1.11e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1060285632   6 RCQGCGHVqSPPGAFVFNCPRCQGTNWTPADG 37
Cdd:COG0375    72 RCRDCGKE-FELEELFLRCPKCGSPDLEILSG 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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