NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1197511395|ref|YP_009368070|]
View 

NADH dehydrogenase subunit 4L (mitochondrion) [Lepilemur edwardsi]

Protein Classification

NADH-ubiquinone oxidoreductase chain 4L( domain architecture ID 10009568)

NADH-ubiquinone oxidoreductase chain 4L is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) and is believed to belong to the minimal assembly required for catalysis; Complex I functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.34e-37

NADH dehydrogenase subunit 4L; Provisional


:

Pssm-ID: 177169  Cd Length: 98  Bit Score: 120.81  E-value: 2.34e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1197511395 81 VSNTYGLDHVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.34e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 120.81  E-value: 2.34e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1197511395 81 VSNTYGLDHVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 7.58e-12

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 56.03  E-value: 7.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  3 SISTNIILAFTIALTGMLvFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1197511395 83 NTYGLDHVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 1.09e-03

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 35.04  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395 12 FTIALTGMLVfRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLDHVQ 91
Cdd:COG0713   14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


                 ....*
gi 1197511395 92 NLNLL 96
Cdd:COG0713   93 DLNEL 97
 
Name Accession Description Interval E-value
ND4L MTH00107
NADH dehydrogenase subunit 4L; Provisional
 1-98 2.34e-37

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177169  Cd Length: 98  Bit Score: 120.81  E-value: 2.34e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00107   1 MSLIYMNIMLAFTISLLGLLMYRSHLMSSLLCLEGMMLSLFIMATLTILNTHFTLASMMPIILLVFAACEAAVGLALLVM 80

                         90
                 ....*....|....*...
gi 1197511395 81 VSNTYGLDHVQNLNLLQC 98
Cdd:MTH00107  81 VSNTYGTDYVQNLNLLQC 98
ND4L MTH00126
NADH dehydrogenase subunit 4L; Provisional
 11-98 1.34e-22

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177185  Cd Length: 98  Bit Score: 83.48  E-value: 1.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395 11 AFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLDHV 90
Cdd:MTH00126  11 AFILGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWALQLESTSFSAAPMLLLAFSACEASAGLALLVATARTHGTDRL 90


                 ....*...
gi 1197511395 91 QNLNLLQC 98
Cdd:MTH00126  91 QNLNLLQC 98
ND4L MTH00125
NADH dehydrogenase subunit 4L; Provisional
 1-98 1.75e-21

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177184  Cd Length: 98  Bit Score: 80.66  E-value: 1.75e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00125   1 MTPTHFSLYTAFMLSLLGLSFHRTHLMSALLCLESMMLSLFIMLSLWPITTQTPSFTPMPIILLTFSACEAGTGLALLVA 80

                         90
                 ....*....|....*...
gi 1197511395 81 VSNTYGLDHVQNLNLLQC 98
Cdd:MTH00125  81 TTRTHGSDHLKNLNLLQC 98
ND4L MTH00067
NADH dehydrogenase subunit 4L; Provisional
 8-98 2.75e-18

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177139  Cd Length: 98  Bit Score: 72.71  E-value: 2.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  8 IILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGL 87
Cdd:MTH00067   8 FYSAFLLGLMGLAFHRTHLLSALLCLEGMMLSLFIALSLWSTQFESLSYFSLPMFMLTFSACEASTGLALMVATTRTHGT 87

                         90
                 ....*....|.
gi 1197511395 88 DHVQNLNLLQC 98
Cdd:MTH00067  88 DHLKNLNLLQC 98
ND4L MTH00181
NADH dehydrogenase subunit 4L; Provisional
 9-96 1.35e-12

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214450  Cd Length: 93  Bit Score: 58.03  E-value: 1.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  9 ILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLD 88
Cdd:MTH00181   6 ISAFILLLLGLSLYKTHLLSLLLCLEGMMLFLFLLLALFSLLSSSSSMLMFGLILLTFSACEAVLGLSLLVATNRTHGSD 85


                 ....*...
gi 1197511395 89 HVQNLNLL 96
Cdd:MTH00181  86 HLLKFNLL 93
Oxidored_q2 pfam00420
NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;
3-98 7.58e-12

NADH-ubiquinone/plastoquinone oxidoreductase chain 4L;


Pssm-ID: 425672  Cd Length: 95  Bit Score: 56.03  E-value: 7.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  3 SISTNIILAFTIALTGMLvFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVMVS 82
Cdd:pfam00420  1 AYLLLSGLLFLIGLYGLL-LRRNLLRVLLSLELMLNAVNLALVLFGRLTADPLPQALILTAIVIAAAEAAVGLALLVRIY 79

                         90
                 ....*....|....*.
gi 1197511395 83 NTYGLDHVQNLNLLQC 98
Cdd:pfam00420 80 RTHGTDDVDSLNLLKG 95
ND4L MTH00043
NADH dehydrogenase subunit 4L; Validated
 1-97 2.43e-09

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 214410  Cd Length: 98  Bit Score: 49.92  E-value: 2.43e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00043   1 MNIILIIILSSFFLGLLGILINRLHLLSILLCLELLLISLFLNISIWSLNYGNFSNLSFSLLLLTLSACEASIGLSLMVL 80

                         90
                 ....*....|....*..
gi 1197511395 81 VSNTYGLDHVQNLNLLQ 97
Cdd:MTH00043  81 LSRNHNSDLVASLNLLQ 97
ND4L MTH00188
NADH dehydrogenase subunit 4L; Provisional
 8-98 3.04e-07

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177237  Cd Length: 97  Bit Score: 44.19  E-value: 3.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  8 IILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYtvSFIMPILLLVLAACEAAIGLALLVMVSNTYGL 87
Cdd:MTH00188   9 ILLFVVLGLFTFLLNRKHLLMLLLSLEAIMLSLFWFLLVGLSYMEK--ELYLSLVLLTFAACEASVGLALLVSLIRSHGS 86

                         90
                 ....*....|.
gi 1197511395 88 DHVQNLNLLQC 98
Cdd:MTH00188  87 DYVSSLNLIKC 97
ND4L MTH00149
NADH dehydrogenase subunit 4L; Provisional
 9-98 1.06e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 214434  Cd Length: 97  Bit Score: 40.21  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  9 ILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILliMNMHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLD 88
Cdd:MTH00149  10 LFGFLMGVFALLFQYKHLLSILLSLEALMLSLLVMMFS--SSGLISFSSYLFLIILTFGACEASLGLSLLVSLIRLHGND 87

                         90
                 ....*....|
gi 1197511395 89 HVQNLNLLQC 98
Cdd:MTH00149  88 YVSSLSSLKF 97
ND4L MTH00162
NADH dehydrogenase subunit 4L; Provisional
 8-92 3.13e-05

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177218  Cd Length: 89  Bit Score: 38.98  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  8 IILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMpiLLLVLAACEAAIGLALLVMVSNTYGL 87
Cdd:MTH00162   7 FLFMFFSGLLVFLSKRKHLLLMLLSLEFMVLSLFFLLFLYLSFFNYELYFLL--FFLTFSVCEGALGLSILVSMIRSHGN 84


                 ....*
gi 1197511395 88 DHVQN 92
Cdd:MTH00162  85 DYFSS 89
ND4L MTH00013
NADH dehydrogenase subunit 4L; Validated
 1-98 4.44e-05

NADH dehydrogenase subunit 4L; Validated


Pssm-ID: 133655  Cd Length: 97  Bit Score: 38.58  E-value: 4.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  1 MPSISTNIILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHyTVSFIMPILLLVLAACEAAIGLALLVM 80
Cdd:MTH00013   1 MMSPLFILSISPFISMFNLSLQRKHLLMSLLSLEAMILSLALFIPLSLMFAN-QVNGMLAIVLLTFGACEASLGLSLLVL 79

                         90
                 ....*....|....*...
gi 1197511395 81 VSNTYGLDHVQNLNLLQC 98
Cdd:MTH00013  80 MTRSYGNDMLKSLTSNKC 97
NuoK COG0713
NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; ...
 12-96 1.09e-03

NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 11 or 4L (chain K) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440477  Cd Length: 99  Bit Score: 35.04  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395 12 FTIALTGMLVfRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLDHVQ 91
Cdd:COG0713   14 FAIGLYGVLT-RRNLIVVLMSIELMLNAVNLNLVAFSRYLGDLDGQVFALFVIAVAAAEVAVGLAIIVALYRNRGTIDVD 92


                 ....*
gi 1197511395 92 NLNLL 96
Cdd:COG0713   93 DLNEL 97
PRK05715 PRK05715
NADH-quinone oxidoreductase subunit NuoK;
12-96 2.09e-03

NADH-quinone oxidoreductase subunit NuoK;


Pssm-ID: 180218  Cd Length: 100  Bit Score: 34.38  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  12 FTIALTGMLVFRSHLMSsLLCLEGMMLSMfILSILLIMNMHYTVS-FIMPILLLVLAACEAAIGLALLVMVSNTYGLDHV 90
Cdd:PRK05715   15 FCIGLVGLLLRRNAIVV-LMSIELMLNAV-NLNFVAFSSYLGDLDgQVFAFFVITVAAAEAAIGLAILLQLYRNRGTIDV 92


                  ....*.
gi 1197511395  91 QNLNLL 96
Cdd:PRK05715   93 DDLNEL 98
ND4L MTH00180
NADH dehydrogenase subunit 4L; Provisional
 9-97 2.49e-03

NADH dehydrogenase subunit 4L; Provisional


Pssm-ID: 177231  Cd Length: 99  Bit Score: 34.24  E-value: 2.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511395  9 ILAFTIALTGMLVFRSHLMSSLLCLEGMMLSMFILSILLIMNMHYTVSFIMPILLLVLAACEAAIGLALLVMVSNTYGLD 88
Cdd:MTH00180  10 IILFILGVLGIVLNRSNLIIMLMSIELMLLAISLLFLINSVAIDNLIGQIFTIMILTVAAAESAIGLAILVAYYRIRGTI 89


                 ....*....
gi 1197511395 89 HVQNLNLLQ 97
Cdd:MTH00180  90 AVKSLNLLR 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH