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Conserved domains on  [gi|1197511454|ref|YP_009368138|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Lepilemur milanoii]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 8.24e-74

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 218.90  E-value: 8.24e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454  81 TWGSSIVVWGSLLMGLIMELMVVLWVVGQNSFEVVVGFGDLEDWVAFVGKEIGVVREDSLGVAVLYNCVSWFMVVAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1197511454 161 FVSVLIVIEIVR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 8.24e-74

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 218.90  E-value: 8.24e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454  81 TWGSSIVVWGSLLMGLIMELMVVLWVVGQNSFEVVVGFGDLEDWVAFVGKEIGVVREDSLGVAVLYNCVSWFMVVAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1197511454 161 FVSVLIVIEIVR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 5.50e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.42  E-value: 5.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454  21 SKPSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPETWGSSIVVWGSLLMGLIMEL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454 101 MVVLWVVGQNSFEVVVGFGDLEDWVAFVGKeigvvredslgvaVLYNCVSWFMVVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAAAPDVGNIEAIGE-------------LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 8.24e-74

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 218.90  E-value: 8.24e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454  81 TWGSSIVVWGSLLMGLIMELMVVLWVVGQNSFEVVVGFGDLEDWVAFVGKEIGVVREDSLGVAVLYNCVSWFMVVAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1197511454 161 FVSVLIVIEIVR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 6.43e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 114.85  E-value: 6.43e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454  81 TWGSSIVVwgSLLMGLIMELMVVLWVVGQNSFEVVVGFGDledwvafVGKEIGVVREDSLGVAVLYNCVSWFMVVAGWSL 160
Cdd:MTH00138   81 SWGSWSVL--GYVVGYLVGVVLAAGLFWGGWYEGSWVVVD-------ELKEFSVLRGDVGGVALMYSSGGGMLVICAWVL 151

                         170
                  ....*....|..
gi 1197511454 161 FVSVLIVIEIVR 172
Cdd:MTH00138  152 LLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 6.46e-30

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 107.24  E-value: 6.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454  81 TWGsSIVVWGSLLMGLIMelMVVLWVvgqnsfeVVVGFGDLEDWVAFVGKEIGVVREDSLGVAVLYNCVSWFMVVAGWSL 160
Cdd:MTH00065   81 AWG-SWSVLVYVLFYLLL--LIVGYI-------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|..
gi 1197511454 161 FVSVLIVIEIVR 172
Cdd:MTH00065  151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 5.41e-23

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 89.42  E-value: 5.41e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454  81 TWGSSIVVWGSLLMGLIMELMVVLWVVGQNSFEVVVGFGDLEDWVafvgkeigVVREDSLGVAVLYNCVSWFMVVAGWSL 160
Cdd:MTH00115   81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGLF--------VVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                         170
                  ....*....|..
gi 1197511454 161 FVSVLIVIEIVR 172
Cdd:MTH00115  153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 8.01e-15

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 68.09  E-value: 8.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454  81 TWGSSIVVWGSL--LMGLIMELMVVLWVVGQNSFEVVVGFGDLEdwvafvgkeigvvredSLGVAVLYNCVSWFMVVAGW 158
Cdd:MTH00214   81 SWGGWSVLLFFLfyLLGLGFVGFYFYGGWEMLSWMGVDEANNLD----------------LSGVSDLYSRGFFLLLLGGV 144

                         170
                  ....*....|....
gi 1197511454 159 SLFVSVLIVIEIVR 172
Cdd:MTH00214  145 VLFLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 4-172 1.98e-10

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 56.07  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454   4 MMFLLSVVFVLG---FMSFSSkpSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00045    1 MVFYLFLILMLFgstLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454  81 TWGSSIVVWGSLLMGLIMELMVVLWVVGQNSFEVVVGFGDLEdwvafvgkeigvvredslGVAVLYNCVSWFMVVAGWSL 160
Cdd:MTH00045   79 VSNLGEVLVLSLLLSLWVFISFDNFLELSNNNWSLVSLSDLV------------------GSSELYNSGGLYLLLGGFIL 140

                         170
                  ....*....|..
gi 1197511454 161 FVSVLIVIEIVR 172
Cdd:MTH00045  141 LVALVVALVISF 152
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 5.50e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 49.42  E-value: 5.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454  21 SKPSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEYPETWGSSIVVWGSLLMGLIMEL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511454 101 MVVLWVVGQNSFEVVVGFGDLEDWVAFVGKeigvvredslgvaVLYNCVSWFMVVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAAAPDVGNIEAIGE-------------LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 4-78 1.59e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 37.29  E-value: 1.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1197511454   4 MMFLLSVVFVLGFMsFSSKPSPIYGGVGLVVSGAVGSMIVMGFGGSFVGLMMFLIYLGGMLVVFGYTTAMATEEY 78
Cdd:MTH00212    3 LSLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALSPNEH 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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