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Conserved domains on  [gi|1197511496|ref|YP_009368190|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Lepilemur grewcockorum]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.95e-76

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 225.84  E-value: 1.95e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496  81 TWGSSVVVWGSLLMGLIMELLVVVWVMGQDGFEVVVGFDDLEDWVAFVGKEVGVVREDSLGVAALYNHVNWFMVVAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1197511496 161 FVSVLIVIEIIR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.95e-76

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 225.84  E-value: 1.95e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496  81 TWGSSVVVWGSLLMGLIMELLVVVWVMGQDGFEVVVGFDDLEDWVAFVGKEVGVVREDSLGVAALYNHVNWFMVVAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1197511496 161 FVSVLIVIEIIR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 1.51e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 50.96  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496  21 SKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPETWGSSVVVWGSLLMGLIMEL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496 101 LVVVWVMGQDGFEVVVGFDDLEDWVAFVGKevgvvredslgvaALYNHVNWFMVVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAAAPDVGNIEAIGE-------------LLFTDYLLPFELASVLLLVALVGAIVL 141
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-172 1.95e-76

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 225.84  E-value: 1.95e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496  81 TWGSSVVVWGSLLMGLIMELLVVVWVMGQDGFEVVVGFDDLEDWVAFVGKEVGVVREDSLGVAALYNHVNWFMVVAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|..
gi 1197511496 161 FVSVLIVIEIIR 172
Cdd:MTH00109  162 FIGVFVIIEITR 173
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-172 5.47e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 115.24  E-value: 5.47e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496  81 TWGSSVVVwGSLLMGLIMELLVVVWVMGQDGFEVVVGFDDLedwvafvgKEVGVVREDSLGVAALYNHVNWFMVVAGWSL 160
Cdd:MTH00138   81 SWGSWSVL-GYVVGYLVGVVLAAGLFWGGWYEGSWVVVDEL--------KEFSVLRGDVGGVALMYSSGGGMLVICAWVL 151

                         170
                  ....*....|..
gi 1197511496 161 FVSVLIVIEIIR 172
Cdd:MTH00138  152 LLTLFVVLELTR 163
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-172 1.25e-30

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 109.17  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496  81 TWGSSVVVWgsllmglimeLLVVVWVMGQDGFEVVVGFDDLEDWVAFVGKEVGVVREDSLGVAALYNHVNWFMVVAGWSL 160
Cdd:MTH00065   81 AWGSWSVLV----------YVLFYLLLLIVGYILFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|..
gi 1197511496 161 FVSVLIVIEIIR 172
Cdd:MTH00065  151 LLTLFVVLEVTR 162
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-172 4.70e-23

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 89.81  E-value: 4.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496  81 TWGSSVVVWGSLLMGLIMELLVVVWVMGQDGFEVVVGFDDLEDWVafvgkevgVVREDSLGVAALYNHVNWFMVVAGWSL 160
Cdd:MTH00115   81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGLF--------VVRLDFSGVSLFYSSGGGGLLVCGWGL 152

                         170
                  ....*....|..
gi 1197511496 161 FVSVLIVIEIIR 172
Cdd:MTH00115  153 LLTLFVVLELVR 164
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-172 3.32e-14

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 66.55  E-value: 3.32e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496   1 MIYMMFLLSVVFVLGFMSFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPE 80
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496  81 TWGSSVVVWGSLLMGLIMELLVVVWVMGQDGFEVVVGfddledwvafvgkeVGVVREDSLGVAALYNHVNWFMVVAGWSL 160
Cdd:MTH00214   81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGV--------------DEANNLDLSGVSDLYSRGFFLLLLGGVVL 146

                         170
                  ....*....|..
gi 1197511496 161 FVSVLIVIEIIR 172
Cdd:MTH00214  147 FLVLFVVLELVR 158
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 4-170 1.80e-11

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 59.15  E-value: 1.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496   4 MMFLLSVVFVLG---FMSFSSkpSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPe 80
Cdd:MTH00045    1 MVFYLFLILMLFgstLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496  81 twgsSVVVWGSLlmgLIMELLVVVWvmgqdgfeVVVGFDDLEDWvaFVGKEVGVVREDSLGVAALYNHVNWFMVVAGWSL 160
Cdd:MTH00045   78 ----SVSNLGEV---LVLSLLLSLW--------VFISFDNFLEL--SNNNWSLVSLSDLVGSSELYNSGGLYLLLGGFIL 140

                         170
                  ....*....|
gi 1197511496 161 FVSVLIVIEI 170
Cdd:MTH00045  141 LVALVVALVI 150
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
21-170 1.51e-08

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 50.96  E-value: 1.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496  21 SKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMATEEYPETWGSSVVVWGSLLMGLIMEL 100
Cdd:pfam00499   5 TSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLLLLA 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496 101 LVVVWVMGQDGFEVVVGFDDLEDWVAFVGKevgvvredslgvaALYNHVNWFMVVAGWSLFVSVLIVIEI 170
Cdd:pfam00499  85 LLLLVLLSASLTPAAAAAAPDVGNIEAIGE-------------LLFTDYLLPFELASVLLLVALVGAIVL 141
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 4-104 8.57e-05

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 40.76  E-value: 8.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1197511496   4 MMFLLSVVFVLGFMsFSSKPSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMAteeyPETWG 83
Cdd:MTH00212    3 LSLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALS----PNEHL 77

                          90       100
                  ....*....|....*....|.
gi 1197511496  84 SSVVVWGSLLMGLIMELLVVV 104
Cdd:MTH00212   78 FFKKYFKGFGMILISLNLYLL 98
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 4-74 2.00e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 36.79  E-value: 2.00e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1197511496   4 MMFLLSVVFVLGFMSFSSKpSPIYGGVGLVISGAVGCMIVMGFGGSFVGLMVFLVYLGGMLVVFGYTTAMA 74
Cdd:MTH00152    3 LMILLSVCFSLFLLLPLSK-QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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