|
Name |
Accession |
Description |
Interval |
E-value |
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
1-749 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 1191.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 1 MISKVVKSSGITEEFSKDKILKVIEFACENTEADPQAILDAAMSSITDGMNTKDIQKQVIKAATNMISVEEPDYQYVAGR 80
Cdd:PHA02572 2 MIINVIKSSGVSQPFDLEKIHKVLEWACEGTGVDPSELEENSKIQLRDGMTTKDIQEILIKSAADLISVEEPDYQYVAAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 81 LTMYTLRKDVYGQFDPISLYDHISKLVDLGFYDKDLLKQYSPADIEYLNLHIDHSRDMNFTYAGAMQLKEKYLVRNRVTK 160
Cdd:PHA02572 82 LLMFALRKQVYGQFEPPSFIDHISKCVNEGKYDPEILSKYSAEEITYLESFIDHDRDFEFTYAGAMQLKEKYLVQDRSTG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 161 EMYETPQFLYMGIAMALHQSE-KENRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIESGDSLKSINDTSAS 239
Cdd:PHA02572 162 EIYETPQFAYMLIAMALHQDEpKEDRLEHVIRFYNAVSTRKISLPTPIMAGVRTPTRQFSSCVVIESGDSLDSINKTAMA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 240 IISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSATLNYPMWHLEVEKLLVLKNNK 319
Cdd:PHA02572 242 IVKYISKRAGIGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLVLKNNK 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 320 GTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDVDCGRLYEDFYdADDTKFRKRYASLEMNHVIRKKRIKASELFTA 399
Cdd:PHA02572 322 GVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGGELYDAYF-ADQDRFRELYEALEKDPSVRKKRIKAQELFLL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 400 FATERAGTGRIYCLFVDNMNKQTPYKEKIKMSNLCQEIFLPTYAMGS--NQEEIALCTLSAINLGMIESTDDYLELARIV 477
Cdd:PHA02572 401 LLKERSETGRIYIMFIDHCNNHSPFKDPIRQSNLCCEIALPTKPLNHidGEGEIALCTLSAIVLGNFEDQDEIEELAEVA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 478 VRSLDNLLDYQDYPVKQALAAKKRRALGVGVVNLAYFLAKNYVGYNDKAAlSLVHEHIEAMQFSLLQASMELAKERGRSE 557
Cdd:PHA02572 481 VRALDNLLDYQDYPVPAALKAKKRRSLGVGVTNYAHYLAKNFASYEDANA-DLVHELFERLQYYLIKASNKLAKEKGACE 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 558 WHDRTKWADGLLPIDWYNKNVDDLTPNDLKQDWEWLRGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKA 637
Cdd:PHA02572 560 YFSDTKYSRGELPIDWYKKKVDELVAPKYNCDWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRGPVSIKK 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 638 SKDGSFNQVVPDVEFLADEYEPLWKMVNRGGmTGYLSICAVIQKFFDQGISANTSYIPSNYEDNKLPIHVILRDVVFANK 717
Cdd:PHA02572 640 SKEGPFNQVVPNVETLKDLYDLLWDLAKKGN-KGYLTQVAIMQKFVDQAISANTSYDPENYPNGKVPMSVMLDDLLYFYY 718
|
730 740 750
....*....|....*....|....*....|....*
gi 1859646359 718 YGMKSLYYHNTRDGS---EEGIEVTKEADCAGCSI 749
Cdd:PHA02572 719 YGGKTLYYHNTRDGKgteDYEIETPKAEDCDSCKL 753
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
142-729 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 543.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 142 YAGAMQLKEKYLVRNRVTKEMYETPQFLYMGIAMALHQSE-KENRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSS 220
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESPQEAYMRVAMGLASLEpKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 221 CVKIESGDS-LKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSAT 299
Cdd:TIGR02506 81 CFLLDVTDDtLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 300 LNYPMWHLEVEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDvDCGRLYEDFYDaddtKFRKRYAS 379
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPY-DVPGLYGLYGE----EFEEEYER 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 380 LEMNHVIRKK--RIKASELFTAFATERAGTGRIYCLFVDNMNKQTPYK---EKIKMSNLCQEIFLPTYamGSNQEEIALC 454
Cdd:TIGR02506 236 LEKDVEARKKirKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKtggGAIKMSNLCTEITQPTD--DSHKGETAVC 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 455 TLSAINLG--MIESTDDYLEL---ARIVVRSLDNLLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAAL 528
Cdd:TIGR02506 314 NLASVNLAnfVMEDKFDFSELedaVRIAVRFLDNVIDLQNYPTAPAaKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEAR 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 529 SLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLPIDWYNKNVDDLTPNDLKQ-DWEWLRGQIRMYGLRNDTV 607
Cdd:TIGR02506 394 DLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTSMAPTEeDWEALRERIKEYGLRNSQL 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 608 TAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGSFNQV--------------------------------VPDVEFLAD 655
Cdd:TIGR02506 474 TALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPnkylmkeleelglwdadrrgdivenvgspqpiAAIPETLKY 553
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1859646359 656 EYEPLWKMVNRggmtGYLSICAVIQKFFDQGISANTsyipsnYEDNKLPIHVILRDVVFANKYGMKSLYYHNTR 729
Cdd:TIGR02506 554 KYKTAYELDQE----ALIDMAADRQKFVDQSISLNL------FLTEEVTAKDLLKLLLLAWKKGLKTMYYCRSR 617
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
85-741 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 534.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 85 TLRKDVYGQFDpiSLYDHISKlVDLGFYDKDLLKqyspADIEYLNLHIDHSRDMNFTYAGAMQLKEKYLVRNrVTKEMYE 164
Cdd:COG0209 1 QLRKEALGQYK--SFSEKIKY-VEEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKD-EDGKPLE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 165 TPQFLYMGIAMALHQSEK-ENRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIESGDSLKSINDT--SASII 241
Cdd:COG0209 73 TPQDLFMRVAMGLAAAEKpEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPVEDSLESIFDAlkDAALL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 242 SyiSQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSATLNYPMWHLEVEKLLVLKNNKGT 321
Cdd:COG0209 153 S--KSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 322 DETRIRGLDYSVHINKLFLERLRDDGYITLFSPDvDCGRLYEDFYDAddtkFRKRYASLEMNHVIRKKrIKASELFTAFA 401
Cdd:COG0209 231 ERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPR-EVPDLYGLYGEE----FEEAYEEYEADGRVYKT-IKARELWRKIL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 402 TERAGTGRIYCLFVDNMNKQ--TPYKEKIKMSNLCQEIFLPTYAmgsnqEEIALCTLSAINLG--MIESTDDYLELARIV 477
Cdd:COG0209 305 ESAWETGEPGILFKDTINRRnpLPHLGVIHSSNLCGEIPLLPYE-----SEDASCNLGSINLAkfVKDGEFDWEKLEETV 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 478 ---VRSLDNLLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKER 553
Cdd:COG0209 380 rtaVRFLDNVIDINDYPVPEIeKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKER 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 554 GRSEWHDRTKWADGLLPIDwynKNVDDLTPnDLKQDWEWLRGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLV 633
Cdd:COG0209 460 GAFPAFEGSKYAKGILPFD---KYLDDLLI-PTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 634 SVKASKD-GSFNQVVPDVEFLADEYEpLW--KMVNRGGMTG--------------------------YLSICAVIQKFFD 684
Cdd:COG0209 536 YVRKVLDgGEFTVVNPYLVRALKELG-LWdeELVEKIKEDGsvqdidelpeelkelyvtayeidpewHIDMQAARQKHVD 614
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*....
gi 1859646359 685 QGISANTsYIPSNY--EDnklpihvILRDVVFANKYGMKSLYYHNTRDGSEEGIEVTKE 741
Cdd:COG0209 615 QAISKTL-NLPNDAtvED-------LAELYLLAWKLGLKGIYYYRDGSRTGQVLSTGKK 665
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
219-726 |
5.49e-155 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 459.36 E-value: 5.49e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 219 SSCVKIESGDSLKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSA 298
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 299 TLNYPMWHLEVEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDVdcgrlYEDFYDADDTKFRKRYA 378
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPRE-----APDLEDLYGEEFEKEYY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 379 SLEMNHVIRKKRIKASELFTAFATERAGTGRIYCLFVDNMNKQTPYKE--KIKMSNLCQEIFLPTYAmgsnqEEIALCTL 456
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHlgTIKSSNLCTEIVQPTSP-----SEIAVCNL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 457 SAINLGMIEST------DDYLELARIVVRSLDNLLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALS 529
Cdd:pfam02867 231 ASINLAKFVEFggtfdfEKLREVVKLAVRALDNVIDINDYPVPEArRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARD 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 530 LVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLPIDWYNKNVDDLTPNDLKQDWEWLRGQIRMYGLRNDTVTA 609
Cdd:pfam02867 311 LNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFAPKASKTREDWEELREDIKKYGLRNSQLTA 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 610 QMPAESSSQLLNATNGIEPVRSLVSVKASKDgsfnqvvPDVEFLadeYEPLWKMvnrgGMTGYLSICAVIQKFFDQGISA 689
Cdd:pfam02867 391 IAPTGSISQIAGATESIEPIFSNVYSRKVLS-------EETKEY---YKTAYDI----DQKAHIDMAAARQPFVDQSISK 456
|
490 500 510
....*....|....*....|....*....|....*..
gi 1859646359 690 NTsYIPSNYednklPIHVILRDVVFANKYGMKSLYYH 726
Cdd:pfam02867 457 TL-FLPNDA-----TTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
166-728 |
6.68e-135 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 406.54 E-value: 6.68e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 166 PQFLYMGIAMALHQsekeNRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIESGDSLKSINDTSASIISYIS 245
Cdd:cd01679 1 PQDRLMRVALGLAS----GDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVDDSLESIYDTIKECAQLSK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 246 QRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSATLNYPMWHLEVEKLLVLKNNKGTDETR 325
Cdd:cd01679 77 IGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 326 IRGLDYSVHINKLFLERlrddgyitlfspdvdcgrlyedfydaddtkfrkryaslemnhVIRkkrikasELFTAFATERA 405
Cdd:cd01679 157 ARDLFYGVWIPDLFMER------------------------------------------VER-------DLWRKILESQF 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 406 GTGRIYCLFVDNMNKQTPYKE--KIKMSNLCQEIFLPTYAMGSNQEEIALCTLSAINLGMIESTDDYLELARIVVRSLDN 483
Cdd:cd01679 188 ETGYPYILFKDTCNRKNPQKHlgTIKSSNLCTEILQPTSPSEDEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRALDN 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 484 LLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGrsewhdrt 562
Cdd:cd01679 268 VIDLNYYPVPEAkRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG-------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 563 kwadgllpidwynknvddltpndlkqdwewlrgqirmyGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGS 642
Cdd:cd01679 340 --------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGE 381
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 643 FNQVVPDVEFLADEY--EPLWKMVNrggMTGYLSICAVIQKFFDQGISANTsYIPSNYEDNKLpihviLRDVVFANKYGM 720
Cdd:cd01679 382 FPVVNPHLEKDLWEYglYKTAYEID---QRWLIDLAADRQKHIDQGQSLNL-FLTPPATTRDL-----NSLYFYAWKKGL 452
|
....*...
gi 1859646359 721 KSLYYHNT 728
Cdd:cd01679 453 KTLYYLRT 460
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
1-749 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 1191.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 1 MISKVVKSSGITEEFSKDKILKVIEFACENTEADPQAILDAAMSSITDGMNTKDIQKQVIKAATNMISVEEPDYQYVAGR 80
Cdd:PHA02572 2 MIINVIKSSGVSQPFDLEKIHKVLEWACEGTGVDPSELEENSKIQLRDGMTTKDIQEILIKSAADLISVEEPDYQYVAAR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 81 LTMYTLRKDVYGQFDPISLYDHISKLVDLGFYDKDLLKQYSPADIEYLNLHIDHSRDMNFTYAGAMQLKEKYLVRNRVTK 160
Cdd:PHA02572 82 LLMFALRKQVYGQFEPPSFIDHISKCVNEGKYDPEILSKYSAEEITYLESFIDHDRDFEFTYAGAMQLKEKYLVQDRSTG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 161 EMYETPQFLYMGIAMALHQSE-KENRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIESGDSLKSINDTSAS 239
Cdd:PHA02572 162 EIYETPQFAYMLIAMALHQDEpKEDRLEHVIRFYNAVSTRKISLPTPIMAGVRTPTRQFSSCVVIESGDSLDSINKTAMA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 240 IISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSATLNYPMWHLEVEKLLVLKNNK 319
Cdd:PHA02572 242 IVKYISKRAGIGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEVEDLLVLKNNK 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 320 GTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDVDCGRLYEDFYdADDTKFRKRYASLEMNHVIRKKRIKASELFTA 399
Cdd:PHA02572 322 GVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGGELYDAYF-ADQDRFRELYEALEKDPSVRKKRIKAQELFLL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 400 FATERAGTGRIYCLFVDNMNKQTPYKEKIKMSNLCQEIFLPTYAMGS--NQEEIALCTLSAINLGMIESTDDYLELARIV 477
Cdd:PHA02572 401 LLKERSETGRIYIMFIDHCNNHSPFKDPIRQSNLCCEIALPTKPLNHidGEGEIALCTLSAIVLGNFEDQDEIEELAEVA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 478 VRSLDNLLDYQDYPVKQALAAKKRRALGVGVVNLAYFLAKNYVGYNDKAAlSLVHEHIEAMQFSLLQASMELAKERGRSE 557
Cdd:PHA02572 481 VRALDNLLDYQDYPVPAALKAKKRRSLGVGVTNYAHYLAKNFASYEDANA-DLVHELFERLQYYLIKASNKLAKEKGACE 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 558 WHDRTKWADGLLPIDWYNKNVDDLTPNDLKQDWEWLRGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKA 637
Cdd:PHA02572 560 YFSDTKYSRGELPIDWYKKKVDELVAPKYNCDWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRGPVSIKK 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 638 SKDGSFNQVVPDVEFLADEYEPLWKMVNRGGmTGYLSICAVIQKFFDQGISANTSYIPSNYEDNKLPIHVILRDVVFANK 717
Cdd:PHA02572 640 SKEGPFNQVVPNVETLKDLYDLLWDLAKKGN-KGYLTQVAIMQKFVDQAISANTSYDPENYPNGKVPMSVMLDDLLYFYY 718
|
730 740 750
....*....|....*....|....*....|....*
gi 1859646359 718 YGMKSLYYHNTRDGS---EEGIEVTKEADCAGCSI 749
Cdd:PHA02572 719 YGGKTLYYHNTRDGKgteDYEIETPKAEDCDSCKL 753
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-749 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 1041.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 4 KVVKSSGITEEFSKDKILKVIEFACENTE--ADPQAILDAAMSsITDGMNTKDIQKQVIKAATNMISVEEPDYQYVAGRL 81
Cdd:PRK09103 3 LVTKRDGRTERINLDKIHRVITWAAEGLHnvSVSQVELRSHIQ-FYDGIKTSDIHETIIKAAADLISRDAPDYQYLAARL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 82 TMYTLRKDVYGQFDPISLYDHISKLVDLGFYDKDLLKQYSPADIEYLNLHIDHSRDMNFTYAGAMQLKEKYLVRNRVTKE 161
Cdd:PRK09103 82 AIFHLRKKAYGQFEPPALYDHVVKMVEMGKYDKHLLEDYTEEEFDQMDTFIDHWRDMNFSYAAVKQLEGKYLVQNRVTGE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 162 MYETPQFLYMGIAMALHQS-EKENRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIESGDSLKSINDTSASI 240
Cdd:PRK09103 162 IYESAQFLYILVAACLFSNyPKETRLDYVKRFYDAVSTFKISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 241 ISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSATLNYPMWHLEVEKLLVLKNNKG 320
Cdd:PRK09103 242 VKYVSQRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPIWHLEVESLLVLKNNRG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 321 TDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDvDCGRLYEDFYdADDTKFRKRYASLEMNHVIRKKRIKASELFTAF 400
Cdd:PRK09103 322 VEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPS-DVPGLYDAFF-ADQDEFERLYTKYEQDDSIRKKRVKAVELFSLM 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 401 ATERAGTGRIYCLFVDNMNKQTPYKEK---IKMSNLCQEIFLPTYAMGS-NQE--EIALCTLSAINLGMIESTDDYLELA 474
Cdd:PRK09103 400 MQERASTGRIYIQNVDHCNTHSPFDPKvapVRQSNLCLEIALPTKPLNDvNDEngEIALCTLSAFNLGAINSLDELEELA 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 475 RIVVRSLDNLLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKER 553
Cdd:PRK09103 480 DLAVRALDALLDYQDYPIPAAkRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSANNLTHKTFEAIQYYLLKASNELAKEQ 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 554 GRSEWHDRTKWADGLLPIDWYNKNVDDLTPNDLKQDWEWLRGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLV 633
Cdd:PRK09103 560 GACPWFNETTYAQGILPIDTYKKDLDAICNEPLHYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEPPRGYV 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 634 SVKASKDGSFNQVVPDVEFLADEYEPLWKMVNrggMTGYLSICAVIQKFFDQGISANTSYIPSNYEDNKLPIHVILRDVV 713
Cdd:PRK09103 640 SIKASKDGILKQVVPDYERLKDAYELLWEMPN---NDGYLQLVGIMQKFVDQSISANTNYDPSRFPSGKVPMKQLLKDLL 716
|
730 740 750 760
....*....|....*....|....*....|....*....|..
gi 1859646359 714 FANKYGMKSLYYHNTRDGSEEGIE----VTKEADCAG--CSI 749
Cdd:PRK09103 717 TAYKFGVKTLYYHNTRDGAEDAQDdlqpSIQDDGCEGgaCKI 758
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
142-729 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 543.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 142 YAGAMQLKEKYLVRNRVTKEMYETPQFLYMGIAMALHQSE-KENRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSS 220
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAATGAIYESPQEAYMRVAMGLASLEpKDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 221 CVKIESGDS-LKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSAT 299
Cdd:TIGR02506 81 CFLLDVTDDtLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 300 LNYPMWHLEVEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDvDCGRLYEDFYDaddtKFRKRYAS 379
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPY-DVPGLYGLYGE----EFEEEYER 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 380 LEMNHVIRKK--RIKASELFTAFATERAGTGRIYCLFVDNMNKQTPYK---EKIKMSNLCQEIFLPTYamGSNQEEIALC 454
Cdd:TIGR02506 236 LEKDVEARKKirKVSARDLMKDILRTRVETGRPYILFKDAVNKHNPFKtggGAIKMSNLCTEITQPTD--DSHKGETAVC 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 455 TLSAINLG--MIESTDDYLEL---ARIVVRSLDNLLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAAL 528
Cdd:TIGR02506 314 NLASVNLAnfVMEDKFDFSELedaVRIAVRFLDNVIDLQNYPTAPAaKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEAR 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 529 SLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLPIDWYNKNVDDLTPNDLKQ-DWEWLRGQIRMYGLRNDTV 607
Cdd:TIGR02506 394 DLNDRIFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTSMAPTEeDWEALRERIKEYGLRNSQL 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 608 TAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGSFNQV--------------------------------VPDVEFLAD 655
Cdd:TIGR02506 474 TALMPTASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPnkylmkeleelglwdadrrgdivenvgspqpiAAIPETLKY 553
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1859646359 656 EYEPLWKMVNRggmtGYLSICAVIQKFFDQGISANTsyipsnYEDNKLPIHVILRDVVFANKYGMKSLYYHNTR 729
Cdd:TIGR02506 554 KYKTAYELDQE----ALIDMAADRQKFVDQSISLNL------FLTEEVTAKDLLKLLLLAWKKGLKTMYYCRSR 617
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
85-741 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 534.00 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 85 TLRKDVYGQFDpiSLYDHISKlVDLGFYDKDLLKqyspADIEYLNLHIDHSRDMNFTYAGAMQLKEKYLVRNrVTKEMYE 164
Cdd:COG0209 1 QLRKEALGQYK--SFSEKIKY-VEEGLYDERLLE----EDLEELAAAIDPERDRFFSYNALKTLYDRYLLKD-EDGKPLE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 165 TPQFLYMGIAMALHQSEK-ENRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIESGDSLKSINDT--SASII 241
Cdd:COG0209 73 TPQDLFMRVAMGLAAAEKpEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPVEDSLESIFDAlkDAALL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 242 SyiSQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSATLNYPMWHLEVEKLLVLKNNKGT 321
Cdd:COG0209 153 S--KSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGD 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 322 DETRIRGLDYSVHINKLFLERLRDDGYITLFSPDvDCGRLYEDFYDAddtkFRKRYASLEMNHVIRKKrIKASELFTAFA 401
Cdd:COG0209 231 ERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPR-EVPDLYGLYGEE----FEEAYEEYEADGRVYKT-IKARELWRKIL 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 402 TERAGTGRIYCLFVDNMNKQ--TPYKEKIKMSNLCQEIFLPTYAmgsnqEEIALCTLSAINLG--MIESTDDYLELARIV 477
Cdd:COG0209 305 ESAWETGEPGILFKDTINRRnpLPHLGVIHSSNLCGEIPLLPYE-----SEDASCNLGSINLAkfVKDGEFDWEKLEETV 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 478 ---VRSLDNLLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKER 553
Cdd:COG0209 380 rtaVRFLDNVIDINDYPVPEIeKANRRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKER 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 554 GRSEWHDRTKWADGLLPIDwynKNVDDLTPnDLKQDWEWLRGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLV 633
Cdd:COG0209 460 GAFPAFEGSKYAKGILPFD---KYLDDLLI-PTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLV 535
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 634 SVKASKD-GSFNQVVPDVEFLADEYEpLW--KMVNRGGMTG--------------------------YLSICAVIQKFFD 684
Cdd:COG0209 536 YVRKVLDgGEFTVVNPYLVRALKELG-LWdeELVEKIKEDGsvqdidelpeelkelyvtayeidpewHIDMQAARQKHVD 614
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*....
gi 1859646359 685 QGISANTsYIPSNY--EDnklpihvILRDVVFANKYGMKSLYYHNTRDGSEEGIEVTKE 741
Cdd:COG0209 615 QAISKTL-NLPNDAtvED-------LAELYLLAWKLGLKGIYYYRDGSRTGQVLSTGKK 665
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
219-726 |
5.49e-155 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 459.36 E-value: 5.49e-155
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 219 SSCVKIESGDSLKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSA 298
Cdd:pfam02867 1 SSCFLLSVEDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 299 TLNYPMWHLEVEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDVdcgrlYEDFYDADDTKFRKRYA 378
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPRE-----APDLEDLYGEEFEKEYY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 379 SLEMNHVIRKKRIKASELFTAFATERAGTGRIYCLFVDNMNKQTPYKE--KIKMSNLCQEIFLPTYAmgsnqEEIALCTL 456
Cdd:pfam02867 156 EREENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHlgTIKSSNLCTEIVQPTSP-----SEIAVCNL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 457 SAINLGMIEST------DDYLELARIVVRSLDNLLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALS 529
Cdd:pfam02867 231 ASINLAKFVEFggtfdfEKLREVVKLAVRALDNVIDINDYPVPEArRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARD 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 530 LVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLPIDWYNKNVDDLTPNDLKQDWEWLRGQIRMYGLRNDTVTA 609
Cdd:pfam02867 311 LNDKIFETMYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFAPKASKTREDWEELREDIKKYGLRNSQLTA 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 610 QMPAESSSQLLNATNGIEPVRSLVSVKASKDgsfnqvvPDVEFLadeYEPLWKMvnrgGMTGYLSICAVIQKFFDQGISA 689
Cdd:pfam02867 391 IAPTGSISQIAGATESIEPIFSNVYSRKVLS-------EETKEY---YKTAYDI----DQKAHIDMAAARQPFVDQSISK 456
|
490 500 510
....*....|....*....|....*....|....*..
gi 1859646359 690 NTsYIPSNYednklPIHVILRDVVFANKYGMKSLYYH 726
Cdd:pfam02867 457 TL-FLPNDA-----TTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
166-728 |
6.68e-135 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 406.54 E-value: 6.68e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 166 PQFLYMGIAMALHQsekeNRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIESGDSLKSINDTSASIISYIS 245
Cdd:cd01679 1 PQDRLMRVALGLAS----GDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVDDSLESIYDTIKECAQLSK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 246 QRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSATLNYPMWHLEVEKLLVLKNNKGTDETR 325
Cdd:cd01679 77 IGGGIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 326 IRGLDYSVHINKLFLERlrddgyitlfspdvdcgrlyedfydaddtkfrkryaslemnhVIRkkrikasELFTAFATERA 405
Cdd:cd01679 157 ARDLFYGVWIPDLFMER------------------------------------------VER-------DLWRKILESQF 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 406 GTGRIYCLFVDNMNKQTPYKE--KIKMSNLCQEIFLPTYAMGSNQEEIALCTLSAINLGMIESTDDYLELARIVVRSLDN 483
Cdd:cd01679 188 ETGYPYILFKDTCNRKNPQKHlgTIKSSNLCTEILQPTSPSEDEPGEDAVCNLASINLGNFVTFEKLEEVVKLAVRALDN 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 484 LLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGrsewhdrt 562
Cdd:cd01679 268 VIDLNYYPVPEAkRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG-------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 563 kwadgllpidwynknvddltpndlkqdwewlrgqirmyGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGS 642
Cdd:cd01679 340 --------------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGE 381
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 643 FNQVVPDVEFLADEY--EPLWKMVNrggMTGYLSICAVIQKFFDQGISANTsYIPSNYEDNKLpihviLRDVVFANKYGM 720
Cdd:cd01679 382 FPVVNPHLEKDLWEYglYKTAYEID---QRWLIDLAADRQKHIDQGQSLNL-FLTPPATTRDL-----NSLYFYAWKKGL 452
|
....*...
gi 1859646359 721 KSLYYHNT 728
Cdd:cd01679 453 KTLYYLRT 460
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-748 |
3.44e-103 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 333.70 E-value: 3.44e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 1 MISKVVKSSGITEEFSKDKILKVIEFACENTEA-DPqaiLDAAMSSIT---DGMNTKDIQKQVIKAA------------T 64
Cdd:PRK07088 1 MNIKIKKRDGQYEPLQVEKTKKMVKLACEGLYGcDP---LELELDSRIqfrDGMTTKEIQKSLIQTAiekviqnskdnnG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 65 NMISVEEPDYQYVAGRLTMYTLRKDV-----YGQFDPISLYDHISKLVDLGFYDKDLLKQYSPADIEYLNLHIDHSRDMN 139
Cdd:PRK07088 78 NNTKKTNPNWQYVAARLYVFDLYKEArinrhYNSFGYGDYYELVKKLVEEKLYGEYLLQNYSKEEIKELEKYIKPERDFL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 140 FTYAGAMQLKEKYLVRNrVTKEMYETPQFLYMGIAMALHQSE-KENRLQHVINYYNAASLFKISIPTPILGGARTPTRQF 218
Cdd:PRK07088 158 FNYEGLKLLADRYLVKG-FNREILELPQERFMGIAMHLAIPEgKEKRVYYAKKFYDLLSELKATVATPTLSNAGTPFYQL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 219 SSCVKIESGDSLKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSA 298
Cdd:PRK07088 237 SSCFISVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKGGA 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 299 TLNYPMWHLEVEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSP---DVDCGRLYEDFYDADDTK-FR 374
Cdd:PRK07088 317 AITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPheiKKVKGYSLEDYYDEEDRKeFT 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 375 KRYASLEMNHVIRKKRIKASELFTAFATERAGTGRIYCLFVDNMNKQTPYKEK--IKMSNLCQEIFLPTYAMGSNQEEI- 451
Cdd:PRK07088 397 KKYLECEEDTNIPRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKgmIYSSNLCHEIAQNMSESELLEEEIi 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 452 -----------------ALCTLSAINLGMIEStDDYLELARIVVRSLDNLLDYQDYPVKQA-LAAKKRRALGVGVVNLAY 513
Cdd:PRK07088 477 dengyyevvqkikagdmVTCNLNSIVLGNVDD-EELEEVIPTQIRMLDNVISLNYYPVPEAeITSDKYRAIGLGTSGYHH 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 514 FLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADG-LLPIDWYNknvddltpndlKQDWEW 592
Cdd:PRK07088 556 MLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETGkYFERRGYN-----------SERWKK 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 593 LRGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKaSKDGSFN-QVVPDvefLADEYEPLWKMVNRGGMTG 671
Cdd:PRK07088 625 LKEEIKKYGMRNGYITAVAPTGSTSNIANTTAGIDPVFKRFFME-EKKGSFTpKTAPD---LNEENFWYYKEAHTIDQQW 700
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1859646359 672 YLSICAVIQKFFDQGISANTsYIPSNYEDNKlpihvILRDVVFANKYGMKSLYYhnTRDGSeegIEVTkeaDCAGCS 748
Cdd:PRK07088 701 SIKACGVRQRHIDQAQSFNL-YITPEYKAKQ-----ILNLYIEAWKQGVKTIYY--VRNKS---LEMD---ECTSCS 763
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
47-748 |
9.30e-96 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 313.97 E-value: 9.30e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 47 TDGMNTKDIQKQVIKAATNMISVEEPDYQYVAGRLTMYTLRKDV-----------YGQFdpislYDHISKLVDLGFYDKD 115
Cdd:PRK09209 57 KESVTADDLVDYLIREAEARVDLEEPEWTFFAARLYLNRLYKRAsrnrfydasekYGSF-----VGLQESLAERGIYSND 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 116 LLKQYSPADIEYLNLHIDHSRDMNFTYAGAMQLKEKYLVRNRVtKEMYETPQFLYMGIAMALHQSE-KENRLQHVINYYN 194
Cdd:PRK09209 132 LLKRYSKEELIEAGKMIDPERDKLFTYIGLYLLADRYLATDSD-RNVYELPQERWLTIALYLMQNEpRERRMQLVKEAYW 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 195 AASLFKISIPTPILGGARTPTRQFSSCVKIESGDSLKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGEATHTGV 274
Cdd:PRK09209 211 ALSNLYMTVATPTLANAGKVGGQLSSCFIDTVDDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGV 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 275 IPFYKHF-HTAVkSCSQGALRGGSATLNYPMWHLEVEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERL--RDDGYitL 351
Cdd:PRK09209 291 IPWIKQLnNTAV-SVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVerRGDWY--L 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 352 FSP-DVDC--GRLYEDFYDAD--DTKFRKRYASLEMNHVIRKKRIKASELFTAFATERAGTGRIYCLFVDNMNKQTPYKE 426
Cdd:PRK09209 368 FDPhEVKKvmGWYLEDFYDEKkgDGSFREKYEECVADERLSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKH 447
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 427 K--IKMSNLCQEIFL---PTYAMgsnQEEIA--------------LCTLSAINLGMIeSTDDYLE-LARIVVRSLDNLLD 486
Cdd:PRK09209 448 EgmIYSSNLCTEIMQnmsPTVMI---QEIISggqivitkqpgdfvVCNLSSINLGRA-VTADVLErLIPIQVRMLDNVID 523
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 487 YQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGR------SEWH 559
Cdd:PRK09209 524 LNQLPVPQAtITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKGAypvfkgSDWQ 603
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 560 -----DRTKwadgllpidwYNknvddltpndlKQDWEWLRGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVS 634
Cdd:PRK09209 604 tgeyfERRG----------YN-----------SPQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDPIYSAFY 662
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 635 VKASKDGSFNQVVPDVEflADEYEPLWKMVNRGGMTGYLSICAVIQKFFDQGISANTsYIPSNYEDNK-LPIHVIlrdvv 713
Cdd:PRK09209 663 YEEKKDYRRPVTAPDLS--LDTWPYYEKGAYKVDQFWSIRQNAARQRHVDQSISFNF-YVPSTIRASElLDLHMT----- 734
|
730 740 750
....*....|....*....|....*....|....*
gi 1859646359 714 fANKYGMKSLYYHNTRDGSEEgievtkeaDCAGCS 748
Cdd:PRK09209 735 -AWKEGLKTTYYVRSTDIDIE--------ECEWCS 760
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
4-747 |
2.73e-95 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 313.59 E-value: 2.73e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 4 KVVKSSGITEEFSKDKILKVIEFACENTEADPQAILDA-AMSSITDGMNTKDIQKQVIKAATNMISVEEPDYQYVAGRLT 82
Cdd:PRK08447 3 TVVKRNGRIEPLDISKIQKYTSDAVEGLEGVSQSELEVdAKIQFRDGITTEEIQQTLIKTAVDKIDIDRPNWTFVAARLF 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 83 MYTLRKDVYGQFDPISLYDHISKLVDLGFYDKDLLKQYspaDIEYLNLHIDHSRDMNFTYAGAMQLKEKYLVRNRVTKEM 162
Cdd:PRK08447 83 LYDLYHKVSGFTGYNHLKEYFEKGEKEGRILLGLKEKY---DLDDLNAYIKPERDLQFNYLGIKTLYDRYLIKDRNNNPI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 163 yETPQFLYMGIAMALHQSEKENRlQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIESGDSLKSINDTSASIIS 242
Cdd:PRK08447 160 -ELPQHMFMAIAMFLAQNELDPQ-KWAKKFYDVISKFEVMLATPTLSNARTTRHQLSSCYIGSTPDNIEGIFDSYKEMAL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 243 YISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSATLNYPMWHLEVEKLLVLKNNKGTD 322
Cdd:PRK08447 238 LSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRKGAIAVYLEPWHMDISDFIDLRKNSGEE 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 323 ETRIRGLDYSVHINKLFLERLRDDGYITLFSPdVDCGRLYEDFYDAddtkFRKRYASLEMNHVIRKKRIKASELFTAFAT 402
Cdd:PRK08447 318 RRRAHDLFPALWINDLFMKRVEEDAMWTLFDP-YECKDLTELYGEE----FEKRYLEYEKDEKIIKEYINAKELWKKILT 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 403 ERAGTGRIYCLFVDNMNKQTPYKEK--IKMSNLCQEIFLPT----------YAMGS-----NQEEI-------------- 451
Cdd:PRK08447 393 NYFETGLPFLCFKDNANRANPNAHAgiIRSSNLCTEIFQNTapnhykikieFEDGSieffeEEELVtvdsgitkkakkit 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 452 ----------------------ALCTLSAINLGMIESTDDYLELARIVVRSLDNLLDYQDYPVKQALAAK-KRRALGVGV 508
Cdd:PRK08447 473 sldslkgkkiyivekekkdgktAVCNLASINLSKINTKEDIERVVPIAIRMLDNVIDLNFYPNRKVKATNlKSRAIGLGV 552
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 509 VNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLPIDWYNKNVDDLTPN---- 584
Cdd:PRK08447 553 MGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGIFPIDKANEEAKKLVERgglf 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 585 DLKQDWEWLRGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGSFNQVVPDV-----EFLADEYEP 659
Cdd:PRK08447 633 DSACDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPVYKRKWFEENLSGLIPVVVPNLspetwQYYTPAYDL 712
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 660 LWKMVNRGGmtgylsicAVIQKFFDQGISANTsYIPSNYEDNKlpihvILRDV-VFANKYGMKSLYYHNTR--DGSEEGI 736
Cdd:PRK08447 713 DQKDLIKAA--------AVRQKWIDQGQSLNI-FLSLDKASGK-----YLNEIyTLAWKLGLKSTYYLRSEspESEEVSV 778
|
810
....*....|.
gi 1859646359 737 EvTKEADCAGC 747
Cdd:PRK08447 779 A-DRSIECEGC 788
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-748 |
1.08e-79 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 272.39 E-value: 1.08e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 1 MISKVVKSSGITEefskdkILKVIEFACENTEADPQAILDAAMSSITDGMNTKDIQKQVIKAATNMISVEEPDYQYVAGR 80
Cdd:PRK12364 100 QIIKFFDDDTVLG------VLKEIQKDFPSDEYSLDLLAEKFLSFCKPNMSEGESLAALIKAAVELTTQEAPDWEFIAAR 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 81 LTMYTLRKDV---YGQFDPISLYDHISKLVDLGFYDKDLLKQYSPADIEYLNLHIDHSRDMNFTYAGAMQLKEKYLVRNR 157
Cdd:PRK12364 174 LLMLQFSKKLgksLEKLGIHSFYDKIKYLTEEGLYGSYILEHYSREEIEEAAGFIDPERDKLFTYSGLDLLLKRYVIRTH 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 158 vTKEMYETPQFLYMGIAMALHQSEKENRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIESGDSLKSINdTS 237
Cdd:PRK12364 254 -SHEPLESPQEMFLGIALHLAMPEKQDRMGWVKRFYDMLSKLKVTMATPTLSNARKPFHQLSSCFIDTVPDSLDGIY-RS 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 238 ASIISYISQR-AGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFH-TAVkSCSQGALRGGSATLNYPMWHLEVEKLLVL 315
Cdd:PRK12364 332 IDNFAQVSKFgGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLANdTAV-AVDQLGMRQGAVAVYLDVWHKDIPEFLQL 410
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 316 KNNKGTDETRIRGLDYSVHINKLFLERLRDD--GYITLFSPD---VDCGRLYEDFYDADdtkFRKRYASLEMNHVIRKKR 390
Cdd:PRK12364 411 RTNNGDDRMKAHDVFPAVCYPDLFWKMVRDDinQSWYLFCPHeilTVKGYALEDYYGEE---WEKRYLDCVNDARISKRS 487
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 391 IKASELFTAFATERAGTGRIYCLFVDNMNKQTPYKEK--IKMSNLCQEIFLPTYAMGSNQEEI----------------- 451
Cdd:PRK12364 488 IPIKDLVRLILKSAVETGTPFTFNRDTVNRANPNKHKgmIYCSNLCTEIAQNMSAIETVSTEIetedgdtvvvtttrpgd 567
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 452 -ALCTLSAINLGMIESTDD--YLELARIVVRSLDNLLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAA 527
Cdd:PRK12364 568 fVVCNLASLSLGNIDLEDEeeLEEVVRTVVRALDNVIDLNFYPVPYAqITNKRYRSIGLGVSGYHHALAKNGIRWESEEH 647
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 528 LSLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGllpiDWYNK-NVDDltpndlkQDWEWLRGQIRMYGLRNDT 606
Cdd:PRK12364 648 LEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTG----AYFRKrGYTS-------EEWQRLAREVAENGMRNAY 716
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 607 VTAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGSFNQVVPDvefLADEYEPLWKMVNRGGMTGYLSICAVIQKFFDQG 686
Cdd:PRK12364 717 LLAVAPTSSTSIIAGTTAGVDPVMKRYFLEEKKGALMPRVAPE---LSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQA 793
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1859646359 687 ISANTsYIPSNYEDNKlpihvILRDVVFANKYGMKSLYYhnTRDGSEEgIEvtkeaDCAGCS 748
Cdd:PRK12364 794 QSVNL-YITNEFTMRQ-----VLDLYLLAWEEGVKTIYY--VRSKSLE-VE-----ECESCS 841
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-650 |
2.81e-79 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 274.90 E-value: 2.81e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 5 VVKSSGITEEFSKDKILKVIEFACEN--TEADPQAILDAAMSSITDGMNTKDIQKQVIKAATNMISvEEPDYQYVAGRLT 82
Cdd:PRK12365 238 VLSKDGSTYTMTKSQLLAHFAWACSRfpETTDAALLADMAFANFYSGIKESEVVLACIMAARANIE-KEPDYAFVAAELL 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 83 MYTLRKDVYGQfdpiSLYDHisklvDLGFYDKDLLKQY---------SPA----DIEYLNLHIDHSRDMNFTYAGAMQLK 149
Cdd:PRK12365 317 LDVVYKEALGK----SKYDE-----DLEEAHKDHFKRYilegdtyrlNPElkhyDLDALAEALDLSRDLQFSYMGVQNLY 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 150 EKYLvrNRVTKEMYETPQFLYMGIAMALHQSEKENRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVkiesgds 229
Cdd:PRK12365 388 DRYF--NHHEGRRLETPQIFWMRVSMGLALNEGQDKTSWAITFYNLLSTFRYTPATPTLFNSGMRHSQLSSCY------- 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 230 LKSINDTSASIISYISQRA-------GIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSATLNY 302
Cdd:PRK12365 459 LSTVQDDLVHIYKVISDNAmlskwagGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAVCVYL 538
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 303 PMWHLEVEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDVDCGrlyedFYDADDTKFRKRYASLEM 382
Cdd:PRK12365 539 EVWHLDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPG-----LHEAYGEEFEKLYEEYER 613
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 383 ---NHVIR-KKRIKASELFTAFATERAGTGRIYCLFVD--NMNKQTPYKEKIKMSNLCQEIFLptyamGSNQEEIALCTL 456
Cdd:PRK12365 614 kvdTGEIRlYKKVEAEDLWRKMLSMLYETGHPWMTFKDpsNIRSAQDHKGVVRCSNLCTEILL-----NCSETETAVCNL 688
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 457 SAINL-GMIESTD----DYLELARIVVRSLDNLLDYQDYPVKQALAAK-KRRALGVGVVNLAYFLAKNYVGYNDKAALSL 530
Cdd:PRK12365 689 GSINLvEHIVNDGldeeKLSETISIAIRILDNVIDINFYPTKEAKEANlAHRAIGLGVMGFQDALYKLNISYASQEAVEF 768
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 531 VHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLPIDW------YNKNVDDLTPNDLKQDWEWLRGQIRMYGLRN 604
Cdd:PRK12365 769 ADYSSELIAYYAILASSLLAKERGTYSSYKGSKWDRGYLPIDTiellkeYRGEANLLMDTSSRKDWEPVRSLIKEYGMRN 848
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 1859646359 605 DTVTAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGSFnqVVPDV 650
Cdd:PRK12365 849 SQLMAIAPTATISNIIGVTQSIEPTYKHLFVKSNLSGEF--TIPNV 892
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-746 |
1.11e-78 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 269.49 E-value: 1.11e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 1 MISKVVKSSGITEEFSKDKILKVIEFACEN-TEADPQAILDAAMSSIT--DGMNTKDIQKQVIKAATNMISvEEPDYQYV 77
Cdd:PRK06539 1 MSITVVKRDGSKEPYDANKVNAAIEDAARGlDDAITWVTQLASELEITlfDGITTQQLDEAVIQVALQNVK-DDPAFDTV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 78 AGRLTMYTLRKDVYGQF-DPISLYD--------HISKLVDLGFYDKDLLKQYspaDIEYLNLHIDHSRDMNFTYAGAMQL 148
Cdd:PRK06539 80 AARLLLKKIYKRVLGDYdSPEELQDlhanhfrrTIEKGVAEGLLDSRLGGLF---DLERLAAALDPTRDELLKYIGVVTL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 149 KEKYLVRNRvTKEMYETPQFLYMGIAMALHQSEKeNRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIESGD 228
Cdd:PRK06539 157 NNRYGIRAR-NGDALEVPQYFWMRIAMGLSLNED-DPTSSALAFYEKMSKLEYLAAGSTLVNAGTPYPQLSNCFVMEMQD 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 229 SLKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGSATLNYPMWHLE 308
Cdd:PRK06539 235 DIEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMD 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 309 VEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPdVDCGRLYEdFYDADdtkFRKRYA----SLEMNH 384
Cdd:PRK06539 315 FPEFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDP-LETPDLNE-LYGKA---FSKRYAqyveQAEAGR 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 385 VIRKKRIKASELFTAFATERAGTGRIYCLFVDNMNKQTPYKEK--IKMSNLCQEIFLPtyamgSNQEEIALCTLSAINLG 462
Cdd:PRK06539 390 IRMFKRITAREQFRAILMSLQTTSHPWLTWKDTINNRALNNNTgtIHLSNLCTEICLP-----QDRDNVSVCNLASINLS 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 463 --MIESTDDYLEL---ARIVVRSLDNLLDYQDYPVKQA-LAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIE 536
Cdd:PRK06539 465 rhLADGELDWAQLeesTRLAVRQLDNLIDITASSVKEAdFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIME 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 537 AMQFSLLQASMELAKERGRSEWHDRTKWADGLLPIDWY-----NKNVDDLTPNDLKQDWEWLRGQIRMyGLRNDTVTAQM 611
Cdd:PRK06539 545 HISYAAIDESADLAAERGAYPNFEGSRWSRGMVPVDSIalleaDRGVPVDVNRTTRLDWDALRAKVRG-GMRNATLMAIA 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 612 PAESSSQLLNATNGIEPVRSLVSVKASKDGSFNQV---------------------------VPDVEFLADEYEPLWKMV 664
Cdd:PRK06539 624 PTASIGLVAGTTPGLDPQFSQIFSRSTSSGKFLEVnrnlvadlkelglwetvreeilrsqgdIQEIAAIPDEIKALYRTS 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 665 NRGGMTGYLSICAVIQKFFDQGISANTSYIPSNYEDnklpihviLRDVVFAN-KYGMKSLYYHNT--RDGSEEG-IEVTK 740
Cdd:PRK06539 704 FQLSPYAFLEVAARAQKWVDQAISRNMYLESRDIGD--------MMDIYTAAwEMGVKTTYYLHMkpRHTAEQStVKVNK 775
|
....*.
gi 1859646359 741 EADCAG 746
Cdd:PRK06539 776 SAERRG 781
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-648 |
6.27e-74 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 258.74 E-value: 6.27e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 5 VVKSSGITEEFSKDKILKVIEFACENTEA-DPQAILDAAMSSITDGMNTKDIQKQVIKAATNMISvEEPDYQYVAGRLTM 83
Cdd:PRK07207 151 VTLDDGVRRPLDMARLRALIEEACEGLEAvDAEPILAETLKNLYDGVPMDEVYKALILAARTLIE-KEPNYSYVTARLLL 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 84 YTLRKDVYGQFDPISLYDH--------------ISKLVDLGFYDKDLLkQYspaDIEYLNLHIDHSRDMNFTYAGAMQLK 149
Cdd:PRK07207 230 DTLRREALGFLGVPEEVTQaematryaeyfpafIKKGIEAELLDPKLA-QF---DLERLGAALDPERDLQFTYLGLQTLY 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 150 EKYLVRNRVTKemYETPQFLYMGIAMALHQSEKeNRLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVkiesgds 229
Cdd:PRK07207 306 DRYFLHVDGTR--IELPQAFFMRVAMGLALNEI-DREARAIEFYNLLSSFDFMSSTPTLFNSGTLRPQLSSCY------- 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 230 LKSINDTSASIISYISQRA-------GIGINAGAIRAEGSPIR--NGEAThtGVIPFYKHFH-TAVkSCSQGALRGGSAT 299
Cdd:PRK07207 376 LTTVPDDLDGIYEAIKDNAllskfagGLGNDWTPVRALGSHIKgtNGKSQ--GVVPFLKVVNdTAV-AVNQGGKRKGAVC 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 300 LNYPMWHLEVEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDvDCGRLYEDFYDAddtkFRKRYAS 379
Cdd:PRK07207 453 AYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPS-EVPDLHDLFGKA----FEEAYTA 527
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 380 LE--------MNHvirkKRIKASELFTAFATERAGTGRIYCLFVDNMNKQTPYKEK--IKMSNLCQEIFLPTyamgsNQE 449
Cdd:PRK07207 528 YEakaargeiKLF----KKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQQHVgvVHSSNLCTEITLNT-----SDD 598
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 450 EIALCTLSAINLG--MIESTD-DYLELARIV---VRSLDNLLDYQDYPVKQALAAK-KRRALGVGVVNLAYFLAKNYVGY 522
Cdd:PRK07207 599 EIAVCNLGSVNLVahIKDGAKlDHEKLKRTVstaMRMLDNVIDINYYAVPKARNSNlRHRPVGLGIMGFQDALYLLRIPY 678
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 523 NDKAALSLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLPIDwynkNVDDLTPN-------DLKQ--DWEWL 593
Cdd:PRK07207 679 ASDEAVEFADRSMEAVSYYAIWASTELAEERGRYSSYEGSLWSRGILPID----SLKLLAEArggylevDRSStlDWDAL 754
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*
gi 1859646359 594 RGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGSFNQVVP 648
Cdd:PRK07207 755 RARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPTYQNLYVKSNLSGEFTVVNP 809
|
|
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
5-643 |
4.18e-64 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 228.86 E-value: 4.18e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 5 VVKSSGITEEFSKDKI---LKVIEFACENTEADPQAILDAAMSSITDGMNTKDIQKQVIKAATNMISvEEPDYQYVAGRL 81
Cdd:PLN02437 3 VVKRDGRQETVHFDKItarLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTT-NHPDYAILAARI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 82 TMYTLRKDVYGQFDPI--SLYDHISK-------LVDLGFYDkdLLKQYSpadiEYLNLHIDHSRDMNFTYAGAMQLKEKY 152
Cdd:PLN02437 82 AVSNLHKNTKKSFSETvkDMYNHVNErsglkapLIADDVYD--IIMKNA----ARLDSEIIYDRDFDYDYFGFKTLERSY 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 153 LVRnrVTKEMYETPQFLYMGIAMALHqseKENrLQHVINYYNAASLFKISIPTPILGGARTPTRQFSSCVKIE-SGDSLK 231
Cdd:PLN02437 156 LLK--VNGKVVERPQHMLMRVSVGIH---KDD-IESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICmKDDSIE 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 232 SINDTSASIiSYISQRAG-IGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGA-LRGGSATLNYPMWHLEV 309
Cdd:PLN02437 230 GIYDTLKEC-AVISKSAGgIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGgKRKGAFAIYLEPWHADI 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 310 EKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPD-----VDC-GRLYEDFYdaddTKFRKRYASlemn 383
Cdd:PLN02437 309 FEFLDLRKNHGKEEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNeapglADCwGEEFERLY----TKYEREGKA---- 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 384 hvirKKRIKASELFTAFATERAGTGRIYCLFVDNMNKQTPYKE--KIKMSNLCQEIFLPTyamgsNQEEIALCTLSAINL 461
Cdd:PLN02437 381 ----KKVVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQQNlgTIKSSNLCTEIIEYT-----SPTETAVCNLASIAL 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 462 -------------------GMIESTDDYL------ELARIVVRSLDNLLDYQDYPVKQALAAKKR-RALGVGVVNLAYFL 515
Cdd:PLN02437 452 prfvrekgvpleshpsklvGSLGSKNRYFdfeklaEVTAVVTRNLNKIIDVNYYPVETARRSNMRhRPIGIGVQGLADAF 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 516 AKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLPIDWYNknvddLTPNDlKQDWEWLRG 595
Cdd:PLN02437 532 ILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREGPYETYAGSPVSKGILQPDMWG-----VTPSG-RWDWAALRE 605
|
650 660 670 680
....*....|....*....|....*....|....*....|....*...
gi 1859646359 596 QIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGSF 643
Cdd:PLN02437 606 MISKNGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEF 653
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
132-725 |
1.54e-50 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 186.70 E-value: 1.54e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 132 IDHSRDMNFTYAGAMQLKEKYLVRNrvtkemyETPQFLYMGIAMALHQSEKEnrlqHVINYYNAASLFKISIPTPIL--G 209
Cdd:PRK09102 13 IDRSRDAWLTEFGKATLRDRYLLEG-------ESYQDLFARIAEAYADIDPE----HAQRFYDYMSRGWFMPATPVLsnG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 210 GART--PTrqfsSCVKIESGDSLKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGEAThTGVIPFYKHFHTAVKS 287
Cdd:PRK09102 82 GTDRglPI----SCFLNYVEDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPIRNNGKS-SGIIPFIKVMDSLTLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 288 CSQGALRGGSATLNYPMWHLEVEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDVDCgrlyedfyd 367
Cdd:PRK09102 157 ISQGSLRRGSFAVYLDIEHPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISPKDKS--------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 368 addtkfrkryaslemnhVIRKkrIKASELFTAFATERAGTGRIYCLFVDNMNKQTP--YKE---KIKMSNLCQEIFLPTY 442
Cdd:PRK09102 228 -----------------VIRT--VKARDLWAKILETRIETGEPYLLFIDNVNRALPevYKDlglKVKASNLCSEITLPTG 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 443 AMGSNQEEIALCTLSAINL---GMIESTDDYLELariVVRSLDNLLdyQDYPVKQA-------LAAKKRRALGVGVVNLA 512
Cdd:PRK09102 289 IDHLGEDRTAVCCLSSLNLeyyDEWKDTDAFIED---LMRFLDNVL--QDFIDKAPdemerakYSAMRERSVGLGVMGFH 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 513 YFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGRSEwhdrtkWADGllpidwynknvddltpndlkqdwew 592
Cdd:PRK09102 364 SYLQSKMIPFESVMAKQWNKKIFKHIREQADKASKELAKEKGECP------DAAG------------------------- 412
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 593 lRGQIRmyglRNDTVTAQMPAESSSQLL-NATNGIEPVRSLVSVKASKDGSFNQVVPDVEFLADEY----EPLWK--MVN 665
Cdd:PRK09102 413 -YGVMR----RFSTKMAIAPTASISIILgNTSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLLEEKgkdtDEVWSsiLTN 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 666 RGGM---------------TGY-LSICAVI------QKFFDQGISANTsYIPSN---YEDNKLPIHvilrdvvfANKYGM 720
Cdd:PRK09102 488 EGSVqhldflseeekdvfkTAFeIDQRWIIelaadrQKYIDQAQSLNL-FLPANvpkRDLNKLHFE--------AWKKGV 558
|
....*
gi 1859646359 721 KSLYY 725
Cdd:PRK09102 559 KSLYY 563
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
192-700 |
7.33e-46 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 170.49 E-value: 7.33e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 192 YYNAASLFKISIPTPILGGARTPTR-QFSSC--VKIEsGDSLKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGE 268
Cdd:cd02888 4 FFYLLLSQGFIPNSPTLMNAGTGELgQLSACfvLPVE-DDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 269 ATHTGVIPFYKHFHTAVKSCSQGALRGGS--ATLNYpmWHLEVEKLLVLKNnKGTDETRIRGLDYSVHINKLFLERLRDD 346
Cdd:cd02888 83 GVASGPVSFMRVFDAATGVIKQGGTRRGAnmGVLDV--DHPDIEEFIDAKM-KEEKTVVLQNFNISVAVTDAFMEAVEND 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 347 GYITLFSPDvdcgrlyedfyDADDTKFRKRyaslemnhvirkkrIKASELFTAF---ATERAGTGriyCLFVDNMNKQ-- 421
Cdd:cd02888 160 EPWELRNPR-----------EPDTGKVYRT--------------VPARELWDKIveaAWDSADPG---VLFIDTINRWnp 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 422 TPYKEKIKMSNLCQEIFLPTYamGSnqeeialCTLSAINL----------GMIEsTDDYLELARIVVRSLDNLLDYQDYP 491
Cdd:cd02888 212 LPGLGRINATNPCGEQPLLPY--ES-------CNLGSINLskfvknpfggASFD-FERLREAVRLAVRFLDNVIDVNRYP 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 492 VKQ-ALAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLP 570
Cdd:cd02888 282 LPEiAEETKATRRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDASRYLMLKVI 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 571 IDWynknvddltpndlKQDWEWLRGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVrslvsvkaskdgsfnqvvpdv 650
Cdd:cd02888 362 VNA-------------KELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI--------------------- 407
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 1859646359 651 efladeYEPLW--KMVnrggmtgylsicAVIQKFFDQGISaNTSYIPSNY--ED 700
Cdd:cd02888 408 ------FSPEDhvRMQ------------AALQPWVDGAIS-KTINLPNDAtvED 442
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
147-735 |
1.44e-45 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 172.12 E-value: 1.44e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 147 QLKEKYLVRNRvTKEMYETPQFLYMGIAMAL-HQSEKENR---LQHVINYYNAASLFKISIPTPIL-GGARTPTRQFSSC 221
Cdd:TIGR02504 1 VLAARYLLKDE-DGNIIESPEDLFRRVARALaAAEDKYNSpvwKQWYERFYDLMVNLGFIPNSPTLmNAGGTRLGQLSAC 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 222 VKIESGDSLKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCSQGALRGGS--AT 299
Cdd:TIGR02504 80 FVLPVEDSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGGTRRGAqmGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 300 LNYpmWHLEVEKLLVLKnnkgTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPDVdcgrlyedfydaddtkfrKRYas 379
Cdd:TIGR02504 160 LDV--WHPDIEEFIEAK----AKEGKLQNFNISVGVTDEFMEAVENDEEYELRNPRT------------------GEY-- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 380 lemnhvirkKRIKASELFTAF---ATERAGTGriyCLFVDNMNK--QTPYKEKIKMSNLCQEIFLPTYamGSnqeeialC 454
Cdd:TIGR02504 214 ---------KEVDARELWDKIvesAWKSAEPG---VLFIDTINKwhTCPYGGRINATNPCGEQPLLPY--ES-------C 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 455 TLSAINL-----------GMIEsTDDYLELARIVVRSLDNLLDYQDYPVKQ-ALAAKKRRALGVGVVNLAYFLAKNYVGY 522
Cdd:TIGR02504 273 NLGSINLakfvkndfgdeASFD-FERLREVVRLATRFLDNVIDINVFPLPEiAENTKKTRRIGLGIMGLADLLIKLGIPY 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 523 NDKAALSLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLPIDwynKNVDDLTpndlKQDWEWlrgqIRMYGL 602
Cdd:TIGR02504 352 DSEEARELAEEVMEFIADAAYRASAELAKERGAFPLYDASKYPMGRAMGA---RIPSALP----AEIREA----IRKYGI 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 603 RNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKA-SKDGSFNQVVPDV-----EFLADEYEPLWKMVNRGGMTG----- 671
Cdd:TIGR02504 421 RNAQLTTIAPTGTISLIAGTSSGIEPVFALVYFRNvTVGGELLEVNPLVelalrELGYYSDEIVKYVDEKGTVEGapgpe 500
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 672 ----------------YLSICAVIQKFFDQGISaNTSYIPSNY--EDnklpihvILRDVVFANKYGMKSL--YyhntRDG 731
Cdd:TIGR02504 501 elpkvfvtamdispedHVLMQAAIQPWVDSSIS-KTINMPSDAtvED-------VKAVYLEAWKLGLKGItvY----RDG 568
|
....
gi 1859646359 732 SEEG 735
Cdd:TIGR02504 569 SRSS 572
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
1-641 |
1.51e-24 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 109.56 E-value: 1.51e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 1 MISKVVKSSGITEEFSKDKILKVIEFAC----ENTEADPQAILDAAMSSITDGMNTKDIQKQVIKAATNMIS-VEEPDYQ 75
Cdd:PRK06406 3 MVKEVIKRDGTVVPFDKKKIAMAIYKAMlsvkNGSMEDAEELTDKVVERLKKYERPTVEQIQDIVEKVLMTKkINGKDFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 76 YVAGRLTMY-----TLR--KDVYGQFDPISLYDHISKLVDLGFYDKD---------------LLKQYSPADIEYLNLHID 133
Cdd:PRK06406 83 DVAKSYILYrekrrKIReeKELIGVKDDLKLTLNAIKVLEARYLLKDedgkiietprqmfrrVARHIAIVEALYDDEVYD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 134 HS-----RDMNFTYAGAMQLKEKYLVRNRVTKEMYETPQFLYMgiaMALHQSeKENRLQHVINYYNAASLFKISIP-TPI 207
Cdd:PRK06406 163 KTgkqkeNAEVIGKLSVTQEDMLKRAFRYLKEEGIMKGDFEEF---LDFLKT-KWDSIEEYINKFEEVMSNLKFVPnSPT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 208 LGGARTPTRQFSSCVKIESGDSLKSINDTSASIISYISQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKS 287
Cdd:PRK06406 239 LMNAGTKLGQLSACFVLPVPDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVASGPLSFMRIFDVTTDV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 288 CSQGALRGGS--ATLNYPmwHLEVEKLLVlknNKGTDETRIRGLDYSVHINKLFLERLRDDGYITLFSPdvdcgRLYEDF 365
Cdd:PRK06406 319 IKQGGKRRGAnmGILSYH--HPDIMEFIT---SKDSENKVLSNFNISVAVTDEFFDKLDNDDYYPLRNP-----RNGKEV 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 366 ydaddtkfrkryaslemnhvirkKRIKASELFTAFATERAGTGRIYCLFVDNMNKQTPYKE--KIKMSNLCQEIFLPTYA 443
Cdd:PRK06406 389 -----------------------KRIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKNlgEIESTNPCGEQPLLPYE 445
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 444 MgsnqeeialCTLSAINL------GMIEsTDDYLELARIVVRSLDNLLDYQDYPVKQ-ALAAKKRRALGVGVVNLAYFLA 516
Cdd:PRK06406 446 S---------CNLGSINLskfvenGKID-WDRLRETVHIATRFLDNVIDANKFPVPQiKEMTRMTRKIGLGVMGFADMLI 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 517 KNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERgrsewhdrtkwadGLLPiDWYNKnvddltpndlkqdwEWLRGQ 596
Cdd:PRK06406 516 KLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEER-------------GVFP-AWYGS--------------EWEKKG 567
|
650 660 670 680
....*....|....*....|....*....|....*....|....*
gi 1859646359 597 IRMyglRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKASKDG 641
Cdd:PRK06406 568 IKM---RNSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRHVLNG 609
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
430-651 |
3.67e-21 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 99.46 E-value: 3.67e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 430 MSNLCQEifLPTYamgsnqeEIALCTLSAINLGMIESTDD----------YLELARIVVRSLDNLLDYQDYPVKQA-LAA 498
Cdd:PRK08332 1293 MSHNCGE--EPLY-------EYESCNLASINLAKFVKYDEngkpyfdwdeYAYVIQKVAKYLDNAIDVNKFPLPEIdYNT 1363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 499 KKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWADGLLPID-WYNKN 577
Cdd:PRK08332 1364 KLTRRIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELPVEgFYHPE 1443
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1859646359 578 VDDLTpndlkqdWEWLRGQIRMYGLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGSFNQVVPDVE 651
Cdd:PRK08332 1444 IWNLP-------WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFE 1510
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
137-656 |
1.05e-20 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 97.31 E-value: 1.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 137 DMNFTYAGAMQLKEKYLVRNRVTKEMyETPQFLYMGIAMALHQSEK----ENRLQHVIN-YYNAASLFKISIPTPILGGA 211
Cdd:PRK08665 9 DMKLTDNALTVLEKRYLKKDEDGKPI-ETPEDMFRRVARTIAAAELiydsKADVEALADrFYDLMTSLEFLPNSPTLMNA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 212 RTPTRQFSSCVKIESGDSLKSINDT--SASIISyiSQRAGIGINAGAIRAEGSPIRNGEATHTGVIPFYKHFHTAVKSCS 289
Cdd:PRK08665 88 GRELGQLSACFVLPVGDSIEEIFDAvkHAALIH--KSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIK 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 290 QGALRGGS--ATLNYPmwHLEVEKLLVLKNnkgtDETRIRGLDYSVHINKLFLERLRDDGYITLFSPdvdcgRLYEdfyd 367
Cdd:PRK08665 166 QGGTRRGAnmGILRVD--HPDIMEFITCKE----DNGELTNFNISVAITEAFMEAVEADEEYDLINP-----RTGE---- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 368 addtkfrkryaslemnhviRKKRIKASELFTAFATERAGTGRIYCLFVDNMNKQ--TPYKEKIKMSNLCQEIFLPTYAMg 445
Cdd:PRK08665 231 -------------------VVGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDnpTPHLGEIESTNPCGEQPLLPYES- 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 446 snqeeialCTLSAINLG-MIESTD-DYLELARIV---VRSLDNLLDYQDYPVKQ-ALAAKKRRALGVGVVNLAYFLAKNY 519
Cdd:PRK08665 291 --------CNLGSINLSkMVKNGDvDWEKLREVVhlaVRFLDNVIDANKYPLPQiEEMTKGNRKIGLGVMGWADMLIQLG 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 520 VGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGRSEWHDRTKWA-DGLLPIdwynknvddltpndlkqdwewlrgqir 598
Cdd:PRK08665 363 IPYDSEEAVELAEKVMKFIQDEAHAASRELAEERGPFPNYEGSIYDkDGLGPM--------------------------- 415
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1859646359 599 myglRNDTVTAQMPAESSSQLLNATNGIEPVRSLVSVKASKDGS-FNQVVPDVEFLADE 656
Cdd:PRK08665 416 ----RNATVTTIAPTGTISIIAGCSSGIEPLFALSFTRNVMDGErLVEVNPVFEAAAKE 470
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
213-726 |
1.43e-20 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 94.91 E-value: 1.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 213 TPTRQFSSCVKIESGDSL----KSINDTSASIISYISQR-------------AGIGINA--GAIRAEGSPIRN-GEATHT 272
Cdd:cd00576 17 RPDLPFTGCVLVDYGDSLdpgiKGVNETAKSINEAIQKTyqiialaasnqngGGVSFARasSILSPYGSRDYAkGSGTET 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 273 GVIPFYKHFHTAVKSCSQGALRGGSATLNYPMWHLE-----VEKLLVLKNNKGTDETRIRGLDYSVHINKLFLERLrddg 347
Cdd:cd00576 97 DAVEAADAFNLALKEVGQGNGRTGAATGFIGGVHKGkgdkiSQEFLNLALANGGEGIPLNFPNLSVRVSSDKPGIL---- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 348 yitlfspdvdcgrlyedfydaddtkfrkryaslemnhvirkkrIKASELFTAFATERAGTGRIYCLFVDNmnkqtpykek 427
Cdd:cd00576 173 -------------------------------------------VKAVELKQLIAEEARKTGSPGIFNDEL---------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 428 ikmsNLCQEIFLPTYAmgsnqeeialctLSAINLGMIESTDDYLELARIVVRSLDNLLDYQDYPVKQA-LAAKKRRALGV 506
Cdd:cd00576 200 ----CNLVSLNLARIM------------EKAINGSMDVVLEELEELAFLAVRALDCVIDSHDERIPTIeLGGDERRTVGL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 507 GVVNLAYFLAK---NYVGynDKAALSLVHEHIEAMQFSLLQASMElakergrsewhdrtkwadgllpidwynknvddltp 583
Cdd:cd00576 264 GIAGVADLLIKlglEKVG--DPEADDLAAELVDQLKKHLVKATNE----------------------------------- 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 584 ndlkqdwewlrgqirmygLRNDTVTAQMPAESSSQLLNATNGIEPVRSLVsvkaskdgsfnqvvpdvefladeYEPLWKM 663
Cdd:cd00576 307 ------------------RGFNFLLGLSPSESNSSGAPATNGVSPSRG*I-----------------------AIVLNGD 345
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1859646359 664 VnrgGMTGYLSICAVIQKFFDQGISANTsyipsNYEDNKLPIHVILRDVVFANKYGMKSLYYH 726
Cdd:cd00576 346 I---GPEESLASVAILQFYADNGISDTI-----TIPDSATNLDQLLAVIDGAAAIKTTHVRVN 400
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
328-698 |
9.42e-19 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 91.06 E-value: 9.42e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 328 GLDYSVHINKLFLERLRDDGYITLFSPDVdcgrlyEDFYDADDTKFRKRYASL-------EMNHVIRKKR-IKASELFTA 399
Cdd:PRK08115 368 GANISVCLTKEFMEAVENDEEYELRFPDV------ENYTEEEMEIYNEEWHEVgdvreweKMGYPVRTYRkIKAKELWNL 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 400 F---ATERAGTGriyCLFVDNMNKQT---PYKEKIKMSNLCQEIFLPTYAmgsnqeeiaLCTLSAINLGMI----ESTDD 469
Cdd:PRK08115 442 InicATYSAEPG---IFFIDNANEMTnakAYGQKVVATNPCGEQPLAPYS---------VCNLAAINLANMadkeTKTVD 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 470 YLELARIV---VRSLDNLLDYQDYPVKQ-ALAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQA 545
Cdd:PRK08115 510 YEKLKRTVevgVRMQDNVIDATPYFLEEnKKQALGERRVGLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRT 589
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 546 SMELAKERGR-----SEWHDRTKWADGLLPIDWYNKNVddltPNDLKQDwewlrgqIRMYGLRNDTVTAQMPAESSSQLL 620
Cdd:PRK08115 590 SIELAKEKGSfpflvGQTEEETAKLREAFINTGYMKKM----PEDIRED-------ILKYGIRNSHLLTVAPTGSTGTMV 658
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 621 NATNGIEPVRSLVSVKASKDGSFNQVVPDV--EFL------ADEYEPLWkMVNRGGMT--GYLSICAVIQKFFDQGISaN 690
Cdd:PRK08115 659 GVSTGLEPYFSFSYYRSGRLGKFIEVKADIvqEYLdkhpeaDENHLPEW-FISAMELKpeAHADVQCIIQRWVDSSLS-K 736
|
....*...
gi 1859646359 691 TSYIPSNY 698
Cdd:PRK08115 737 TVNAPKGY 744
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
140-214 |
3.17e-17 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 76.51 E-value: 3.17e-17
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1859646359 140 FTYAGAMQLKEKYLVRNRvTKEMYETPQFLYMGIAMALHQSEK-ENRLQHVINYYNAASLFKISIPTPILGGARTP 214
Cdd:pfam00317 1 LTYLGAKVLEDRYLLKDE-DGELLETPQDMFMRVALALAGAELeEDRLELAEEFYDLLSSLKFLPATPTLMNAGTP 75
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
4-89 |
1.76e-14 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 69.22 E-value: 1.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 4 KVVKSSGITEEFSKDKILKVIEFACENTEADPQAILD----AAMSSITDGMNTKDIQKQVIKAAtnmisVEEPDYQYVAG 79
Cdd:pfam03477 2 KVIKRDGRREPFDKEKIRRAIEKACEKSPDQADELASeveeELEKSLEDGISTEEIQDLVEKTL-----AEHPDYAVARA 76
|
90
....*....|
gi 1859646359 80 RLTMYTLRKD 89
Cdd:pfam03477 77 YILYRNLRKE 86
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
413-630 |
2.82e-13 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 73.29 E-value: 2.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 413 LFVDNMNKQTPYK--EKIKMSNLCQEIFLPTYamGSnqeeialCTLSAINLGMI---------ESTDDYLELA---RIVV 478
Cdd:PRK06948 268 LFVDTIDAANPLRehERIDATNPCGEQPLPPY--GS-------CVLGPIDLSRFvrhpfgvggEPRFDFAALAtavRIQV 338
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 479 RSLDNLLDYQDYPV-KQALAAKKRRALGVGVVNLAYFLAKNYVGYNDKAALSLVHEHIEAMQFSLLQASMELAKERGRSE 557
Cdd:PRK06948 339 RMLDNALDLTRWPLaAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERGAYP 418
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 558 WHDRTKWADG-----LLPidwynKNVddltpndlkqdwewlRGQIRMYGLRNDTVTAQMPAESSSQLL--NATNGIEPVR 630
Cdd:PRK06948 419 LCDPAAHLDAlragpPLP-----HAV---------------CHAIARHGLRNSHLLSFAPVGSVSLAFgdNCSPGIEPAR 478
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
213-648 |
4.75e-07 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 53.44 E-value: 4.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 213 TPTR-QFSSCVKIESGDSLKSIND---TSASIISYISqraGIGINAGAIRAEGSPIRNGeATHTGVIPFYKHFhtavkSC 288
Cdd:PRK06556 143 TESPqQVSACFILSVDDSMESILNwykEEGMLFKGGS---GTGTNLSRIRSSKELLSGG-GTASGPVSFMRGA-----DA 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 289 SQGALRGGSAT--------LNypMWHLEVEKLLvlkNNKGTDETRIRGLdysvhinklflerlRDDGYitlfspDVDCG- 359
Cdd:PRK06556 214 SAGTIKSGGATrraakmviLD--VDHPDIEEFI---ETKAKEEDKIRAL--------------RDAGY------DMDLGg 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 360 ---------------RLYEDFYDA--DDTKF--RKRYASlemnHVIrkKRIKASELFTAFAT---ERAGTGriyCLFVDN 417
Cdd:PRK06556 269 eayssvqyqnannsvRVSDEFMRAveNDGEFglRARTDG----EVI--ETVDAKELFRKIAEaawECADPG---IQYDDT 339
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 418 MNK--QTPYKEKIKMSNLCQE-IFLPTYAmgsnqeeialCTLSAINLGMIESTDD------YLELARIVVRSLDNLLDYQ 488
Cdd:PRK06556 340 INDwhTCPESGRINASNPCSEyMFLDNSS----------CNLASLNLMKFLRDDGtfdvesFRHAVELVITAMEISICFA 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 489 DYPVkQALAAKKR--RALGVGVVNLAYFLAKNYVGYNDKAALSLVhehieAMQFSLLQA-----SMELAKERG------- 554
Cdd:PRK06556 410 DFPT-EKIARNTRafRQLGLGYANLGALLMATGLPYDSDGGRALA-----AAITSLMTGeayrrSAELAGVVGpfegyar 483
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1859646359 555 RSEWHDRT--KWADGllpidwyNKNVDDLTPND------LKQDWEWLRGQIRMYGLRNDTVTAQMPAESSSQLLN-ATNG 625
Cdd:PRK06556 484 NAEPHLRVmrKHAAA-------NDAIRPLGEVDaalleaAKEAWDDALELGEKNGYRNAQASVLAPTGTIGFMMDcDTTG 556
|
490 500
....*....|....*....|....*..
gi 1859646359 626 IEPVRSLVSVKASKDGSF----NQVVP 648
Cdd:PRK06556 557 IEPDFALVKYKKLVGGGSmkivNQTVP 583
|
|
| |
