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Conserved domains on  [gi|1919560240|ref|YP_009927478|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Natula pravdini]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009599)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00166
NADH dehydrogenase subunit 6; Provisional
 2-145 4.72e-23

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214445  Cd Length: 160  Bit Score: 89.10  E-value: 4.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919560240   2 LKLMLSLSMTMNFLILFSFHPLFMTLIIIMQTLMLCLILNFFSLSMWFSYILFLTFLGGMLILFIYMTSLSSNNKLSLNI 81
Cdd:MTH00166    1 KMMLMMLLLILSIIFLFLNHPLSMGLILIIQTILISLLLGLMMKSFWFSYILFLIFLGGMLVLFIYITSLASNEKFKFSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1919560240  82 YKLTSFILFSLLINFFFLYKMDMNYSMIFFqdsfnlqnflIMYEYPKNLNMMYNNPNFMITIMM 145
Cdd:MTH00166   81 KLLILFLLMLLLMLNNFIKNSEMSNFNNNF----------NFFENSFSLSKLYNFPTMLITLFM 134
 
Name Accession Description Interval E-value
ND6 MTH00166
NADH dehydrogenase subunit 6; Provisional
 2-145 4.72e-23

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214445  Cd Length: 160  Bit Score: 89.10  E-value: 4.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919560240   2 LKLMLSLSMTMNFLILFSFHPLFMTLIIIMQTLMLCLILNFFSLSMWFSYILFLTFLGGMLILFIYMTSLSSNNKLSLNI 81
Cdd:MTH00166    1 KMMLMMLLLILSIIFLFLNHPLSMGLILIIQTILISLLLGLMMKSFWFSYILFLIFLGGMLVLFIYITSLASNEKFKFSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1919560240  82 YKLTSFILFSLLINFFFLYKMDMNYSMIFFqdsfnlqnflIMYEYPKNLNMMYNNPNFMITIMM 145
Cdd:MTH00166   81 KLLILFLLMLLLMLNNFIKNSEMSNFNNNF----------NFFENSFSLSKLYNFPTMLITLFM 134
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
 25-145 3.59e-03

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 37.21  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919560240  25 MTLIIIMQTLMLCLILNFFSLSMWFsyILFLTFLGGMLILFI-YMTSLSSNNKLSLNIYKLT-------------SFILF 90
Cdd:cd02076   602 ETLRILVFFTLGILILNFYPLPLIM--IVLIAILNDGATLTIaYDNVPPSPRPVRWNMPELLgiatvlgvvltisSFLLL 679

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1919560240  91 SLLINFFFLYKMDMNY----SMIFFQDSFNLQNFLIMYEYPKNLNMMYNNPNFMITIMM 145
Cdd:cd02076   680 WLLDDQGWFEDIVLSAgelqTILYLQLSISGHLTIFVTRTRGPFWRPRPSPLLFIAVVL 738
 
Name Accession Description Interval E-value
ND6 MTH00166
NADH dehydrogenase subunit 6; Provisional
 2-145 4.72e-23

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214445  Cd Length: 160  Bit Score: 89.10  E-value: 4.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919560240   2 LKLMLSLSMTMNFLILFSFHPLFMTLIIIMQTLMLCLILNFFSLSMWFSYILFLTFLGGMLILFIYMTSLSSNNKLSLNI 81
Cdd:MTH00166    1 KMMLMMLLLILSIIFLFLNHPLSMGLILIIQTILISLLLGLMMKSFWFSYILFLIFLGGMLVLFIYITSLASNEKFKFSL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1919560240  82 YKLTSFILFSLLINFFFLYKMDMNYSMIFFqdsfnlqnflIMYEYPKNLNMMYNNPNFMITIMM 145
Cdd:MTH00166   81 KLLILFLLMLLLMLNNFIKNSEMSNFNNNF----------NFFENSFSLSKLYNFPTMLITLFM 134
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 2-126 6.11e-07

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 46.92  E-value: 6.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919560240   2 LKLMLSLSMTMNFLILFSFHPLFMTLIIIMQTLMLCLILNFFSLSmWFSYILFLTFLGGMLILFIYMTSLSSNNKLSLNI 81
Cdd:MTH00212    3 LSLLLSLLLLLMLLFPLSAHPLTLGVSLLLSSLLSCLIITMESNS-WYGYILFLIYIGGLLVLFGYMVALSPNEHLFFKK 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1919560240  82 YkLTSFILFSLLINFFFLYKMDMNYSMIFFQDSFNLQNFLIMYEY 126
Cdd:MTH00212   82 Y-FKGFGMILISLNLYLLLMTLGSSNFSPMLNLKLELNVSKILSN 125
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 1-127 1.98e-06

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 45.26  E-value: 1.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919560240   1 MLKLMLSLSMTMNFLILFSFHPLFMTLIIIMQTLMLCLILNFFSlSMWFSYILFLTFLGGMLILFIYMTSLSSNNKLSLN 80
Cdd:MTH00152    2 SLMILLSVCFSLFLLLPLSKQPLSLGLVLLLLSLFVCVEIGLTL-SSWYGYLLFLVYVGGLLVMFAYVVSLSPNPLFGSN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1919560240  81 IYKLTSFILFSLLINFFFLYKMDMNYSMIFFQDSFNLQNFLIMYEYP 127
Cdd:MTH00152   81 FKFVFFSLTLFGFLGLFFFFLYLYSSGGLSLSSLFDGSSGSLSFGGG 127
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
 25-145 3.59e-03

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 37.21  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919560240  25 MTLIIIMQTLMLCLILNFFSLSMWFsyILFLTFLGGMLILFI-YMTSLSSNNKLSLNIYKLT-------------SFILF 90
Cdd:cd02076   602 ETLRILVFFTLGILILNFYPLPLIM--IVLIAILNDGATLTIaYDNVPPSPRPVRWNMPELLgiatvlgvvltisSFLLL 679

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1919560240  91 SLLINFFFLYKMDMNY----SMIFFQDSFNLQNFLIMYEYPKNLNMMYNNPNFMITIMM 145
Cdd:cd02076   680 WLLDDQGWFEDIVLSAgelqTILYLQLSISGHLTIFVTRTRGPFWRPRPSPLLFIAVVL 738
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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