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Conserved domains on  [gi|2235262565|ref|YP_010373080|]
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NADH dehydrogenase subunit 2 (mitochondrion) [Teredorus hainanensis]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475933)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-335 7.29e-75

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 233.95  E-value: 7.29e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   1 MKKMPIKMMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMtFIITMM 80
Cdd:MTH00160    1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLF-SIILNM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  81 NFIYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIdLNNNMMVIFIISSSIIGA 160
Cdd:MTH00160   80 LNLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYL-INNNFIIIIIILSAIIGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 161 IMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKLNMMM 240
Cdd:MTH00160  159 IGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 241 SMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGLMYFKENKWNKNFNLKKMNMISLYL 320
Cdd:MTH00160  239 NLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFL 318

                         330
                  ....*....|....*
gi 2235262565 321 NMMSSMGLIMSPLLM 335
Cdd:MTH00160  319 SFISLFGLILSSLLF 333
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-335 7.29e-75

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 233.95  E-value: 7.29e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   1 MKKMPIKMMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMtFIITMM 80
Cdd:MTH00160    1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLF-SIILNM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  81 NFIYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIdLNNNMMVIFIISSSIIGA 160
Cdd:MTH00160   80 LNLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYL-INNNFIIIIIILSAIIGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 161 IMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKLNMMM 240
Cdd:MTH00160  159 IGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 241 SMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGLMYFKENKWNKNFNLKKMNMISLYL 320
Cdd:MTH00160  239 NLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFL 318

                         330
                  ....*....|....*
gi 2235262565 321 NMMSSMGLIMSPLLM 335
Cdd:MTH00160  319 SFISLFGLILSSLLF 333
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-280 4.91e-13

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 68.49  E-value: 4.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  24 ANSWLAVWMGLEMNLMSFIPLISS-QPMLNHKLSSIKYFIIQAISSITLLMTFI----------------ITMMNFIYTN 86
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYwGKSPRSSEAGMKYFLLTLLGSSILLFGISlmynytgtlsfdelskALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  87 MNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILL-MTWQKVAPMTAISYIDLN-------NNMMVIFIISSSII 158
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIRRSLLYlpsspfiQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 159 GAIMGLNQISLRMILSYSSINHIGWMLSSL----QSNMITWTYYMMVYSLLSTLISLLFKSYNLN-----SINELFMINN 229
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGLFLCAGSVIYRrvhtrNIRDYGGLAK 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2235262565 230 QNKLYKLNMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSS 280
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 16-335 9.38e-08

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 53.41  E-value: 9.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  16 LSTIITMTANSWLAVWMGLEMNLMSFIPLISSQpmLNHKLS---SIKYFIIQAISSITLLM-----------------TF 75
Cdd:TIGR01770 113 LGIFLLVSSNDLLSIYLGLELQSLCFYVLAGLK--RKSRFSteaGLKYFILGAFSSGLLLFgisliygftgslnfedlLL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  76 IITMMNFIYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEflswDNCILLMTWQKVAPMTAISYIDLN----------- 144
Cdd:TIGR01770 191 FLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYE----GAPTPVTAFFSIVPKIAIFAVFLRlflyilfgfse 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 145 --NNMMVIFIISSSIIGAIMGLNQISLRMILSYSSINHIGWMLSSL----QSNMITWTYYMMVYSLLST------LISLL 212
Cdd:TIGR01770 267 awQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLlagtLEGIKAVLFYIFIYALMSLgafgvlSLLRS 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 213 FKSYNLNSINELFMINNQNKLYKLNMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFM 292
Cdd:TIGR01770 347 YKDEWIEYISDFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVK 426

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2235262565 293 sagLMYF-KENKWNKNFNLKKMNMISLYLNMMSSMGLIMSPLLM 335
Cdd:TIGR01770 427 ---VMYFdKPERRIPSNPQSKAQSLLLSISALFILFLGLFPSLI 467
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 10-301 5.63e-06

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 47.80  E-value: 5.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  10 FLLTLMLSTI--ITMT-ANSWLAVWMGLEMNLMSFIPLISSqpMLNHKLSS---IKYFIIQAISSITLLM---------- 73
Cdd:COG1007   104 FYALLLFATLgmMLMAsANDLLTLFLGLELLSLSLYVLVAF--RRDDRRSSeaaLKYFLLGALSSGFLLYgisllygatg 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  74 TFIITMMNFIYTNMNIMIMIMMMSLLM-------KMGAAPLHFWFPEVME--------FLSwdncillmTWQKVAPMTAI 138
Cdd:COG1007   182 SLNLAGIAAALAAGGANSPLLLLGLVLvlaglafKLSAVPFHMWTPDVYEgaptpvtaFLA--------TAPKIAAFAAL 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 139 ---------SYIDLNNNMMVIFIISSSIIGAIMGLNQISLRMILSYSSINHIGWMLSSL----QSNMITWTYYMMVYSLL 205
Cdd:COG1007   254 lrllveafpGLAADWQLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLaagtPLGVSAALFYLLAYLFM 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 206 --------STLISLLFKSYNLNSINELFminNQNKLYKLNMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILV 277
Cdd:COG1007   334 nlgafaviLLLSRKGGEAEEIEDLAGLA---RRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAV 410

                         330       340
                  ....*....|....*....|....
gi 2235262565 278 MSSIITLYFYLKLFMsagLMYFKE 301
Cdd:COG1007   411 LNSVISAYYYLRVVK---AMYFDE 431
 
Name Accession Description Interval E-value
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-335 7.29e-75

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 233.95  E-value: 7.29e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   1 MKKMPIKMMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMtFIITMM 80
Cdd:MTH00160    1 MMMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLF-SIILNM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  81 NFIYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIdLNNNMMVIFIISSSIIGA 160
Cdd:MTH00160   80 LNLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYL-INNNFIIIIIILSAIIGA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 161 IMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKLNMMM 240
Cdd:MTH00160  159 IGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKIKFLLFL 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 241 SMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGLMYFKENKWNKNFNLKKMNMISLYL 320
Cdd:MTH00160  239 NLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKKKKNKFSLILNFL 318

                         330
                  ....*....|....*
gi 2235262565 321 NMMSSMGLIMSPLLM 335
Cdd:MTH00160  319 SFISLFGLILSSLLF 333
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 4-334 8.82e-44

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 153.55  E-value: 8.82e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   4 MPIKMMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMTFIITMMN-- 81
Cdd:MTH00041    3 RNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWLsg 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  82 ---FIYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYI--DLNNNMMVIFIISSS 156
Cdd:MTH00041   83 swsINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISIsnLLNSNILILCGILSV 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 157 IIGAIMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKL 236
Cdd:MTH00041  163 LVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPISAF 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 237 NMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGLMYFKENK-----WNKNFNLK 311
Cdd:MTH00041  243 LFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFPQHSislfsWRNSGNIT 322

                         330       340
                  ....*....|....*....|...
gi 2235262565 312 KMNMISLYLNMMSSMGLIMSPLL 334
Cdd:MTH00041  323 VYGVILSILSSISILGLLLIPLF 345
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 5-335 8.69e-42

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 148.46  E-value: 8.69e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   5 PIKMMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMTFIITMM---- 80
Cdd:MTH00105    4 LILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMysgq 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  81 -NFIYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYID--LNNNMMVIFIISSSI 157
Cdd:MTH00105   84 wTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISpsINPNLLLTLAILSIL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 158 IGAIMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKLN 237
Cdd:MTH00105  164 IGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLMTSL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 238 MMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGLMYFKEN-----KWNKNfNLKK 312
Cdd:MTH00105  244 ILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTnnmkmKWQFE-NTKP 322

                         330       340
                  ....*....|....*....|...
gi 2235262565 313 MNMISLyLNMMSSMGLIMSPLLM 335
Cdd:MTH00105  323 MTLLPT-LIILSTMLLPLTPMLS 344
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 2-331 1.52e-41

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 147.34  E-value: 1.52e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   2 KKMPIKMMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMTFIITMMn 81
Cdd:MTH00144    1 MSSPSNLLFLFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYN- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  82 fiYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIDLNNNM---MVIFIISSSII 158
Cdd:MTH00144   80 --LSFSWFSMSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLaylLCVISVLSALV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 159 GAIMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNqNKLYKLNM 238
Cdd:MTH00144  158 GSIGGLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSLKP-SYKTGLSI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 239 MMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGLMYFKENKWNKNfnlKKMNMISL 318
Cdd:MTH00144  237 ISLLLSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSS---KVLNSSII 313

                         330
                  ....*....|...
gi 2235262565 319 YLNMMSSMGLIMS 331
Cdd:MTH00144  314 SLNLLGGLLFLLL 326
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 6-335 5.76e-39

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 140.87  E-value: 5.76e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   6 IKMMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMTFIITMM----- 80
Cdd:MTH00200    5 ILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWtsgqw 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  81 NFIYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAIS--YIDLNNNMMVIFIISSSII 158
Cdd:MTH00200   85 GISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIqlAPALNSNILLLLGLLSVLV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 159 GAIMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKLNM 238
Cdd:MTH00200  165 GGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPILSMLL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 239 MMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKL-FMSAGLMYFKENKWNKNFNLKK-MNMI 316
Cdd:MTH00200  245 GLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLsYLTLLTLSPNQINMMSSWRTKSnSNLL 324

                         330
                  ....*....|....*....
gi 2235262565 317 SLYLNMMSSMGLIMSPLLM 335
Cdd:MTH00200  325 VGLLLLLSILGLPLTPQLL 343
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 8-335 1.09e-37

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 137.11  E-value: 1.09e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   8 MMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMTFIITMMNFiyTNM 87
Cdd:MTH00197    1 FLFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNL--YLS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  88 NIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIDLNNNMMVIFIISSSIIGAIMGLNQI 167
Cdd:MTH00197   79 LLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSSSFMGLLICSVLSSLIGGIGGMNQS 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 168 SLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKLNMMMSMMSLGG 247
Cdd:MTH00197  159 NIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLSFLSLGG 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 248 MPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGLMyfkeNKWNKNFNLKKMNMIS-LYLNMMSSM 326
Cdd:MTH00197  239 LPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKSLIL----SNWMINFLMKINLLYSgLFILLMMML 314


                  ....*....
gi 2235262565 327 GLIMSPLLM 335
Cdd:MTH00197  315 PLLMIFTMI 323
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 6-335 2.91e-37

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 136.49  E-value: 2.91e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   6 IKMMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMTfiiTMMNFIYT 85
Cdd:MTH00112    5 AKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFS---STTNAWNT 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  86 --------NMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMT--AISYIDLNNNMMVIFIISS 155
Cdd:MTH00112   82 gqwditqlTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTllLMTSNSLNPTLLLTLAILS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 156 SIIGAIMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYK 235
Cdd:MTH00112  162 TLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTLN 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 236 LNMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGL-----MYFKENKWnkNFNL 310
Cdd:MTH00112  242 TTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTItlppnTTNMMMKW--RTKP 319

                         330       340
                  ....*....|....*....|....*
gi 2235262565 311 KKMNMISLyLNMMSSMGLIMSPLLM 335
Cdd:MTH00112  320 KKNTLTAT-LTTLSTLLLPLSPMIL 343
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 1-293 4.42e-36

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 132.98  E-value: 4.42e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   1 MKKMPIKMMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMTFIITMM 80
Cdd:MTH00011    2 MSTFPTMFLFSSTMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  81 NFIYTNMNIMIMIMMmSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIDLNN--NMMVIFIISSSII 158
Cdd:MTH00011   82 FPSLLKNITALMLLV-SLMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNilPMMTSMAAMSALA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 159 GAIMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKLNM 238
Cdd:MTH00011  161 GGLGGMNQTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSL 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2235262565 239 MMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMS 293
Cdd:MTH00011  241 FIMLLSLGGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFN 295
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 8-335 7.42e-36

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 132.74  E-value: 7.42e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   8 MMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLMTfiiTMMNFIYT-- 85
Cdd:MTH00070    7 SILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFS---STINAWFTge 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  86 ------NMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYID--LNNNMMVIFIISSSI 157
Cdd:MTH00070   84 wtimnmQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQIShlLNSNLLIIMGLLSTL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 158 IGAIMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKLN 237
Cdd:MTH00070  164 IGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTLTSM 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 238 MMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGLMYFKENKWNKNFNLKKMNMIS 317
Cdd:MTH00070  244 MMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFKNKTNN 323

                         330       340
                  ....*....|....*....|
gi 2235262565 318 LY--LNMMSSMGLIMSPLLM 335
Cdd:MTH00070  324 LLslTIILSLMLLPITPTIL 343
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 6-290 1.01e-32

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 124.15  E-value: 1.01e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   6 IKMMFLLTLMLSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLL---MT--FIITMM 80
Cdd:MTH00135    5 VLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILfasTTnaWLTGQW 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  81 NFIYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIDLNN-NMMVIFIISSSIIG 159
Cdd:MTH00135   85 DIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPTNpTLLITLGLTSTLVG 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 160 AIMGLNQISLRMILSYSSINHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKLNMM 239
Cdd:MTH00135  165 GWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPALTALTP 244

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2235262565 240 MSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKL 290
Cdd:MTH00135  245 LILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRL 295
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 16-302 7.03e-18

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 83.54  E-value: 7.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  16 LSTIITMTANSWLAVWMGLEMNLMSFIPLISSQPMLNHKL-SSIKYFIIQAISS------------------ITLLMTFI 76
Cdd:MTH00196    4 LGILCLISSSNWLSVYLAIELQTLSLFILIAQNRGSGYSAeAGLKYFVLGALSSglflfgcallcgttgglhLSYINLVL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  77 ITMMNFIYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIDLNNNMMVIFIISSS 156
Cdd:MTH00196   84 NSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGLNVNILLIGGLFSL 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 157 IIGAIMGLNQISLRMILSYSSINHIGWMLSSLQSNMI----TWTYYMMVYSLLSTLISLLFKSYNLNS--INELFMINNQ 230
Cdd:MTH00196  164 FVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSFesiqASLVYLFIYIIMSICVFSIILALNVYKnlIIEFSGLSRR 243

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2235262565 231 NKLYKLNMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLfmsAGLMYFKEN 302
Cdd:MTH00196  244 LPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI---VKILFFQAN 312
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 9-290 1.06e-16

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 80.45  E-value: 1.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   9 MFLLTLMLSTIITMTANSWLAVWMGLEM-NLMSFIPLISSQPMLNHKLSSIKYFIIQAISSITLLM----------TFII 77
Cdd:MTH00199  101 ILILIVALGSLLLVSSINWLSIYLAIELqTLTLFILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFgcallygltgETSI 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  78 TMMNFIyTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIDLNNNMMVIFIISSSI 157
Cdd:MTH00199  181 QGINSI-LTGDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTNVVLICAVLSII 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 158 IGAIMGLNQISLRMILSYSSINHIGWML--------SSLQSNMItwtyYMMVYSLLSTLISLLFKSYNLNS--INELFMI 227
Cdd:MTH00199  260 YGAIGALNQTKIKRLLAYSGIGHMGFILfgvaigsfESIQASLI----YMIIYVIMSICSFSIILSLKLTKglIVEVSGL 335

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2235262565 228 NNQNKLYKLNMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKL 290
Cdd:MTH00199  336 SRKNPVIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRV 398
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 24-280 4.91e-13

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 68.49  E-value: 4.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  24 ANSWLAVWMGLEMNLMSFIPLISS-QPMLNHKLSSIKYFIIQAISSITLLMTFI----------------ITMMNFIYTN 86
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLLIGYwGKSPRSSEAGMKYFLLTLLGSSILLFGISlmynytgtlsfdelskALTGGLNSSG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  87 MNIMIMIMMMSLLMKMGAAPLHFWFPEVMEFLSWDNCILL-MTWQKVAPMTAISYIDLN-------NNMMVIFIISSSII 158
Cdd:pfam00361  81 LLLLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLaATLVKAGGYGLIRRSLLYlpsspfiQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 159 GAIMGLNQISLRMILSYSSINHIGWMLSSL----QSNMITWTYYMMVYSLLSTLISLLFKSYNLN-----SINELFMINN 229
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALgagtIYGIQAAIFHLLTHGLFSAGLFLCAGSVIYRrvhtrNIRDYGGLAK 240

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2235262565 230 QNKLYKLNMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSS 280
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFLVLAGVVGS 291
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 16-335 9.38e-08

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 53.41  E-value: 9.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  16 LSTIITMTANSWLAVWMGLEMNLMSFIPLISSQpmLNHKLS---SIKYFIIQAISSITLLM-----------------TF 75
Cdd:TIGR01770 113 LGIFLLVSSNDLLSIYLGLELQSLCFYVLAGLK--RKSRFSteaGLKYFILGAFSSGLLLFgisliygftgslnfedlLL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  76 IITMMNFIYTNMNIMIMIMMMSLLMKMGAAPLHFWFPEVMEflswDNCILLMTWQKVAPMTAISYIDLN----------- 144
Cdd:TIGR01770 191 FLSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYE----GAPTPVTAFFSIVPKIAIFAVFLRlflyilfgfse 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 145 --NNMMVIFIISSSIIGAIMGLNQISLRMILSYSSINHIGWMLSSL----QSNMITWTYYMMVYSLLST------LISLL 212
Cdd:TIGR01770 267 awQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLlagtLEGIKAVLFYIFIYALMSLgafgvlSLLRS 346

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 213 FKSYNLNSINELFMINNQNKLYKLNMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFM 292
Cdd:TIGR01770 347 YKDEWIEYISDFAGLFKTNPILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYLRVVK 426

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 2235262565 293 sagLMYF-KENKWNKNFNLKKMNMISLYLNMMSSMGLIMSPLLM 335
Cdd:TIGR01770 427 ---VMYFdKPERRIPSNPQSKAQSLLLSISALFILFLGLFPSLI 467
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
9-301 2.62e-07

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 51.75  E-value: 2.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565   9 MFLLTLM--LSTIITMTANSWLAVWMGLE-MNLMSFIpLISSQpmLNHKLSS---IKYFIIQAISSITLL--MTFIITM- 79
Cdd:PRK05777  105 FYLLVLFalLGMMVMVSANDLLTLFLGLElLSLPLYA-LAALR--RDRRRSLeaaIKYFVLGALASGFLLygMSLLYGAt 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  80 --MNFIYTNMNIMIMIMMMSLLM------------KMGAAPLHFWFPEVME--------FLSwdncillmTWQKVAPMTA 137
Cdd:PRK05777  182 gsLSFAGIAKALADGSGNSLLLLfglvfllvglafKLSAVPFHMWTPDVYEgaptpvtaFLA--------TAPKIAAFAV 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 138 I---------SYIDLNNNMMVIFIISSSIIGAIMGLNQISLRMILSYSSINHIGWML--------SSLQSNMITWTYYM- 199
Cdd:PRK05777  254 LlrllvvafgGLSEDWQQVLAIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLvglaagtaEGYSAVLFYLLAYLf 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 200 MVYSLLSTLISLLFKSYNLNSINELFMINNQNKLYKLNMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILVMS 279
Cdd:PRK05777  334 MTLGAFGVISLLRRKGGEAESISDFAGLSKRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLN 413

                         330       340
                  ....*....|....*....|..
gi 2235262565 280 SIITLYFYLKLFMsagLMYFKE 301
Cdd:PRK05777  414 SAIGAFYYLRVIK---LMYFDE 432
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 10-301 5.63e-06

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 47.80  E-value: 5.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  10 FLLTLMLSTI--ITMT-ANSWLAVWMGLEMNLMSFIPLISSqpMLNHKLSS---IKYFIIQAISSITLLM---------- 73
Cdd:COG1007   104 FYALLLFATLgmMLMAsANDLLTLFLGLELLSLSLYVLVAF--RRDDRRSSeaaLKYFLLGALSSGFLLYgisllygatg 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  74 TFIITMMNFIYTNMNIMIMIMMMSLLM-------KMGAAPLHFWFPEVME--------FLSwdncillmTWQKVAPMTAI 138
Cdd:COG1007   182 SLNLAGIAAALAAGGANSPLLLLGLVLvlaglafKLSAVPFHMWTPDVYEgaptpvtaFLA--------TAPKIAAFAAL 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 139 ---------SYIDLNNNMMVIFIISSSIIGAIMGLNQISLRMILSYSSINHIGWMLSSL----QSNMITWTYYMMVYSLL 205
Cdd:COG1007   254 lrllveafpGLAADWQLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLaagtPLGVSAALFYLLAYLFM 333

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 206 --------STLISLLFKSYNLNSINELFminNQNKLYKLNMMMSMMSLGGMPPFLGFLPKWILIQEMMMNSSYMITMILV 277
Cdd:COG1007   334 nlgafaviLLLSRKGGEAEEIEDLAGLA---RRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAV 410

                         330       340
                  ....*....|....*....|....
gi 2235262565 278 MSSIITLYFYLKLFMsagLMYFKE 301
Cdd:COG1007   411 LNSVISAYYYLRVVK---AMYFDE 431
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 97-290 1.79e-05

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 46.39  E-value: 1.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  97 SLLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIDLNNNMMVIFIISSSIIGAIMGLNQISLRMILSYS 176
Cdd:MTH00198  308 AILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILLTSLVITSKLLLSVAIISLVVGAFGALNQTRIKRLLAYS 387

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 177 SINHIGWML--------SSLQSnmiTWTYyMMVYSLLSTLISLLF------------------KSYNLNSINEL--FMIN 228
Cdd:MTH00198  388 GIGHIGFILigvsagtyESLQA---SWTY-AVTYLVSALASFTVIctleefgtrtptsrqrdgSFGNYNLVRRLvdLTIL 463

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 229 NQNKLY-KLNMMMSMMSLGGMPPFLGFLPKW-ILIQEMMMNSS------YMITMILVMSSIITLYFYLKL 290
Cdd:MTH00198  464 SRGQPYiAFSLAIVFLSLAGIPPLLGFLGKWfILVGSIKIAFSsslsiyYLVALFAIICTCISAFYYIRI 533
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 249-295 3.18e-03

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 38.97  E-value: 3.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 2235262565 249 PPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAG 295
Cdd:COG0651   384 PPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRIFGRAQ 430
PRK07691 PRK07691
putative monovalent cation/H+ antiporter subunit D; Reviewed
 249-324 6.70e-03

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 181085 [Multi-domain]  Cd Length: 496  Bit Score: 38.01  E-value: 6.70e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2235262565 249 PPFLGFLPKWILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGLMYFKENKWNKNFNLKKMNMISLYLNMMS 324
Cdd:PRK07691  387 PPLSGFYGKFFIVEGTFEAGFYVSGIIVLLSSLLVLYSVIKIFLKGFWGEPKGYDLNNKVPVKKLLLPAVVLVAIT 462
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
 98-310 7.66e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 37.54  E-value: 7.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565  98 LLMKMGAAPLHFWFPEVMEFLSWDNCILLMTWQKVAPMTAISYIDLNNNMMVIFIISSSIIgaIMGLNQISLRMILSYSS 177
Cdd:MTH00091   67 LMMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFFSKNFFFLLLFGLLICF--FQMFLLKSYKNLLILSS 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2235262565 178 INHIGWMLSSLQSNMITWTYYMMVYSLLSTLISLLFKSYNLNSINELFMInnqnklyklnmmmsmMSLGGMPPFLGFLPK 257
Cdd:MTH00091  145 TESFNWLILSFFFSFFNVFFLFFYYFLLMLFLIPKFNNVNKLNFVSWETL---------------LVFMNLPFSVTFFVK 209

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2235262565 258 WILIQEMMMNSSYMITMILVMSSIITLYFYLKLFMSAGLMYFKENKWNKNFNL 310
Cdd:MTH00091  210 IFSLSEILKVLGFFLLFLLFLMFLSVLSLSFWLVNLSTKLFLMLFKYNKGFFF 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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