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Conserved domains on  [gi|74310592|ref|YP_313725|]
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ATP synthase F0 subunit 6 (mitochondrion) [Cylindrophis ruffus]

Protein Classification

ATP synthase F0 subunit 6( domain architecture ID 10009573)

ATP synthase F0 subunit 6 is part of the mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V), which produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATP6 MTH00120
ATP synthase F0 subunit 6; Provisional
 1-226 8.29e-91

ATP synthase F0 subunit 6; Provisional


:

Pssm-ID: 177181  Cd Length: 227  Bit Score: 266.31  E-value: 8.29e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPILLI-YTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLI 79
Cdd:MTH00120   1 MNLNFFDQFSSPELLGIPLILLAMLIPALLIpSPKNRLLTNRLTTLQLWLIKLITKQLMLPLNKKGHKWALILTSLMLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   80 LLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVR 159
Cdd:MTH00120  81 LLINLLGLLPYTFTPTTQLSMNMALAIPLWLATVLTGLRNQPTTSLAHLLPEGTPTPLIPALILIETISLLIRPLALGVR 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74310592  160 LTPNITAGHLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQENT 226
Cdd:MTH00120 161 LTANLTAGHLLIQLISTATLNLLPTMPTLSLLTLIILLLLTILELAVAMIQAYVFVLLLSLYLQENT 227
 
Name Accession Description Interval E-value
ATP6 MTH00120
ATP synthase F0 subunit 6; Provisional
 1-226 8.29e-91

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177181  Cd Length: 227  Bit Score: 266.31  E-value: 8.29e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPILLI-YTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLI 79
Cdd:MTH00120   1 MNLNFFDQFSSPELLGIPLILLAMLIPALLIpSPKNRLLTNRLTTLQLWLIKLITKQLMLPLNKKGHKWALILTSLMLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   80 LLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVR 159
Cdd:MTH00120  81 LLINLLGLLPYTFTPTTQLSMNMALAIPLWLATVLTGLRNQPTTSLAHLLPEGTPTPLIPALILIETISLLIRPLALGVR 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74310592  160 LTPNITAGHLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQENT 226
Cdd:MTH00120 161 LTANLTAGHLLIQLISTATLNLLPTMPTLSLLTLIILLLLTILELAVAMIQAYVFVLLLSLYLQENT 227
ATP_synt_6_or_A TIGR01131
ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be ...
 6-225 8.81e-41

ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be designated ATP synthase, F0 subunit A; eukaryotic (chloroplast and mitochondrial) forms should be designated ATP synthase, F0 subunit 6. The F1/F0 ATP synthase is a multisubunit, membrane associated enzyme found in bacteria and mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. Individual subunits in each of these clusters are named differently in prokaryotes and in organelles e.g., mitochondria and chloroplast. The bacterial equivalent of subunit 6 is named subunit 'A'. It has been shown that proton is conducted though this subunit. Typically, deprotonation and reprotonation of the acidic amino acid side-chains are implicated in the process. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273458  Cd Length: 226  Bit Score: 138.88  E-value: 8.81e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592     6 FEQFASPE--ILLLPTNIMSMLIPILLI----YTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLI 79
Cdd:TIGR01131   2 FSQFDISPitLFSLTLLSLILLLSLLIFlissSLSRWLIPSRWQNLMESIYEFVLSIVKSQIGGKKGKFFPLIFTLFLFI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    80 LLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVR 159
Cdd:TIGR01131  82 LISNLLGLIPYSFTPTSHLSFTLGLALPLWLGLTISGFRKHPKGFLAHLVPSGTPLPLIPFLVIIETISYLARPISLSVR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74310592   160 LTPNITAGHLLMTMISSAALSfiNMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQEN 225
Cdd:TIGR01131 162 LFANISAGHLLLTLLSGLLFS--LMSSAIFALLLLILVALIILEIFVAFIQAYVFTLLTCLYLNDA 225
ATP-synt_Fo_a_6 cd00310
ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms ...
 85-223 5.32e-31

ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms are designated as ATP synthase, Fo complex, subunit a; eukaryotic (chloroplast and mitochondrial) forms are designated as ATP synthase, Fo complex, subunit 6. The F-ATP synthases (also called FoF1-ATPases) consist of two structural domains: F1 (factor one) complex containing the soluble catalytic core, and Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. F-ATP synthase has also been found in the archaea Methanosarcina acetivorans. F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis.


Pssm-ID: 349411 [Multi-domain]  Cd Length: 156  Bit Score: 111.34  E-value: 5.32e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592  85 LGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRLTPNI 164
Cdd:cd00310  21 LGLIPYSFTPTSHLNVTLALALIVFLGVHILGIKKHGLGFFLHFLPPGTPLPLAPLMVPIELISELIRPLSLSVRLFANM 100

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 74310592 165 TAGHLLMTMISSAALSFINMyntLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQ 223
Cdd:cd00310 101 FAGHLLLALLSGLVPSLLSS---VGLLPLLLPVALTLLELFVAFIQAYVFTLLTAVYIS 156
ATP-synt_A pfam00119
ATP synthase A chain;
89-223 1.54e-26

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 101.80  E-value: 1.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    89 PYTFTTTSQLSMNMAFAIPMWLGTVITGL-TMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRLTPNITAG 167
Cdd:pfam00119  81 PGGFTVTADINVTLALALIVFLLVHYYGIkKHGLGGYFKKLFVPPVPLPLVPLLLPIEIISEFARPVSLSLRLFGNMLAG 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 74310592   168 HLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQ 223
Cdd:pfam00119 161 HLLLLLLAGLIFALLSAGFLLGVIPPLLGVAWTLFELLVAFIQAYVFTMLTAVYIS 216
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 89-224 1.93e-15

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 72.03  E-value: 1.93e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592  89 PYTFTTTSQLSMNMAFAIPMWLGTVITGLTMK-TSSSLAHMLPEGSPtPLIPFMILIETISLLMRPIALGVRLTPNITAG 167
Cdd:COG0356  78 PGLFPPTADINVTLALALIVFVLVHYYGIKKKgLGGYLKHLFFPPFP-WLAPLMLPIEIISELARPLSLSLRLFGNMFAG 156

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74310592 168 HLLMTMISSAALSFinmynTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQE 224
Cdd:COG0356 157 HIILLLLAGLAPFL-----LLGVLSLLLPVAWTAFELLVGFLQAYIFTMLTAVYISL 208
 
Name Accession Description Interval E-value
ATP6 MTH00120
ATP synthase F0 subunit 6; Provisional
 1-226 8.29e-91

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177181  Cd Length: 227  Bit Score: 266.31  E-value: 8.29e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPILLI-YTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLI 79
Cdd:MTH00120   1 MNLNFFDQFSSPELLGIPLILLAMLIPALLIpSPKNRLLTNRLTTLQLWLIKLITKQLMLPLNKKGHKWALILTSLMLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   80 LLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVR 159
Cdd:MTH00120  81 LLINLLGLLPYTFTPTTQLSMNMALAIPLWLATVLTGLRNQPTTSLAHLLPEGTPTPLIPALILIETISLLIRPLALGVR 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74310592  160 LTPNITAGHLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQENT 226
Cdd:MTH00120 161 LTANLTAGHLLIQLISTATLNLLPTMPTLSLLTLIILLLLTILELAVAMIQAYVFVLLLSLYLQENT 227
ATP6 MTH00073
ATP synthase F0 subunit 6; Provisional
 1-226 4.08e-64

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177144  Cd Length: 227  Bit Score: 198.65  E-value: 4.08e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPILLIYTKPTL-LGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLI 79
Cdd:MTH00073   1 MNLSFFDQFLSPTLLGIPLIMLAMLLPWLLFPTPTNKwLNNRLSTLQIWFLQNFTKQLMLPLNTPGHKWALILTSLMVFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   80 LLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVR 159
Cdd:MTH00073  81 ITMNLLGLLPYTFTPTTQLSLNLGLAVPLWLATVLIGLRNQPTASLGHLLPEGTPTLLIPILIIIETISLFIRPLALGVR 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74310592  160 LTPNITAGHLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQENT 226
Cdd:MTH00073 161 LTANLTAGHLLIQLISTATLVLLPLMPTVSILTMIVLFLLTLLEIAVAMIQAYVFVLLLSLYLQENV 227
ATP6 MTH00132
ATP synthase F0 subunit 6; Provisional
 1-225 5.12e-64

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177190  Cd Length: 227  Bit Score: 198.17  E-value: 5.12e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPILLIYTKPT-LLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLI 79
Cdd:MTH00132   1 MTLSFFDQFMSPTYLGIPLIALALTLPWILFPTPTSrWLNNRLLTLQGWFINRFTQQLLLPLNVGGHKWALLLTSLMLFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   80 LLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVR 159
Cdd:MTH00132  81 ITLNMLGLLPYTFTPTTQLSLNMGLAVPLWLATVIIGMRNQPTHALGHLLPEGTPTPLIPVLIIIETISLFIRPLALGVR 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74310592  160 LTPNITAGHLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQEN 225
Cdd:MTH00132 161 LTANLTAGHLLIQLIATAAFVLLPLMPTVAILTATLLFLLTLLEVAVAMIQAYVFVLLLSLYLQEN 226
ATP6 MTH00179
ATP synthase F0 subunit 6; Provisional
 1-226 6.00e-60

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177230  Cd Length: 227  Bit Score: 187.85  E-value: 6.00e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPILL-IYTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLI 79
Cdd:MTH00179   1 MMLSMFDQFESPSLLGIPLLALALLLPWLLfPSLTNRWLNNRLSTLQSWFFGSFTFQLMQPINKKGHKWAVLFLSLMLFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   80 LLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVR 159
Cdd:MTH00179  81 LTLNLLGLLPYTFTPTTQLSLNLGLALPLWLGTVLYGLFNQPTIALAHLLPEGTPTPLIPMLVWIETISLLIRPLALGVR 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74310592  160 LTPNITAGHLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQENT 226
Cdd:MTH00179 161 LTANITAGHLLMHLISSAVFVLMNFMGMVALLTLLVLFLLTLLEVAVAMIQAYVFVLLLSLYLQENL 227
ATP6 MTH00101
ATP synthase F0 subunit 6; Validated
 1-226 2.52e-59

ATP synthase F0 subunit 6; Validated


Pssm-ID: 177163  Cd Length: 226  Bit Score: 186.31  E-value: 2.52e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPILLIYTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLIL 80
Cdd:MTH00101   1 MNENLFASFITPTILGLPIVTLIIMFPSLLFPTPNRLINNRLISIQQWLIQLTSKQMMTIHNTKGQTWSLMLMSLILFIG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   81 LSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRL 160
Cdd:MTH00101  81 STNLLGLLPHSFTPTTQLSMNLGMAIPLWAGTVITGFRNKTKASLAHFLPQGTPTPLIPMLVIIETISLFIQPMALAVRL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74310592  161 TPNITAGHLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQENT 226
Cdd:MTH00101 161 TANITAGHLLIHLIGGATLALMSISTTTALITFIILILLTILEFAVALIQAYVFTLLVSLYLHDNT 226
ATP6 MTH00035
ATP synthase F0 subunit 6; Validated
 1-225 4.41e-41

ATP synthase F0 subunit 6; Validated


Pssm-ID: 177110  Cd Length: 229  Bit Score: 139.72  E-value: 4.41e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPI--LLIYTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLL 78
Cdd:MTH00035   3 INNSIFGQFSPDTILFIPLTLLSSVIALswLFFINPTNWLPSRSQSIWLTFRQEILKLIFQNTNPNTAPWAGLLTTVFIL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   79 ILLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGV 158
Cdd:MTH00035  83 ILSINVLGLFPYAFTSTSHISLTYSLGIPLWMSVNILGFYLAFNSRLSHLVPQGTPSFLIPLMVWIETLSLFAQPIALGL 162

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 74310592  159 RLTPNITAGHLLMTMISSAALSFINmYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQEN 225
Cdd:MTH00035 163 RLAANLTAGHLLIFLLSTAIWELSN-SPLISIITLIIFFLLFILEIGVACIQAYVFTALVHFYLEQN 228
ATP_synt_6_or_A TIGR01131
ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be ...
 6-225 8.81e-41

ATP synthase subunit 6 (eukaryotes),also subunit A (prokaryotes); Bacterial forms should be designated ATP synthase, F0 subunit A; eukaryotic (chloroplast and mitochondrial) forms should be designated ATP synthase, F0 subunit 6. The F1/F0 ATP synthase is a multisubunit, membrane associated enzyme found in bacteria and mitochondria and chloroplast. This enzyme is principally involved in the synthesis of ATP from ADP and inorganic phosphate by coupling the energy derived from the proton electrochemical gradient across the biological membrane. A brief description of this multisubunit enzyme complex: F1 and F0 represent two major clusters of subunits. Individual subunits in each of these clusters are named differently in prokaryotes and in organelles e.g., mitochondria and chloroplast. The bacterial equivalent of subunit 6 is named subunit 'A'. It has been shown that proton is conducted though this subunit. Typically, deprotonation and reprotonation of the acidic amino acid side-chains are implicated in the process. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273458  Cd Length: 226  Bit Score: 138.88  E-value: 8.81e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592     6 FEQFASPE--ILLLPTNIMSMLIPILLI----YTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLI 79
Cdd:TIGR01131   2 FSQFDISPitLFSLTLLSLILLLSLLIFlissSLSRWLIPSRWQNLMESIYEFVLSIVKSQIGGKKGKFFPLIFTLFLFI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    80 LLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVR 159
Cdd:TIGR01131  82 LISNLLGLIPYSFTPTSHLSFTLGLALPLWLGLTISGFRKHPKGFLAHLVPSGTPLPLIPFLVIIETISYLARPISLSVR 161

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 74310592   160 LTPNITAGHLLMTMISSAALSfiNMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQEN 225
Cdd:TIGR01131 162 LFANISAGHLLLTLLSGLLFS--LMSSAIFALLLLILVALIILEIFVAFIQAYVFTLLTCLYLNDA 225
ATP6 MTH00157
ATP synthase F0 subunit 6; Provisional
 1-224 9.61e-40

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214441  Cd Length: 223  Bit Score: 136.07  E-value: 9.61e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPILLIYTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLIL 80
Cdd:MTH00157   1 MMTNLFSIFDPSTSFNLSLNWLSTFLGLLFIPSSFWLIPSRYNILWNKILKTLHKEFKTLLGPKNKGSTLIFISLFSFIL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   81 LSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRL 160
Cdd:MTH00157  81 FNNFLGLFPYIFTSTSHLSLTLSLALPLWLSFMLFGWINNTNHMFAHLVPQGTPPILMPFMVLIETISNLIRPGTLAVRL 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 74310592  161 TPNITAGHLLMTMISSAALSFINMYNTLSImtmMLLMLLTLLEMAVACIQAYVFILLITLYLQE 224
Cdd:MTH00157 161 AANMIAGHLLLTLLGNTGPSLSSMILSILI---LIQILLLILESAVAIIQSYVFSVLSTLYSSE 221
ATP6 MTH00173
ATP synthase F0 subunit 6; Provisional
 89-224 4.47e-32

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214448  Cd Length: 231  Bit Score: 116.50  E-value: 4.47e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   89 PYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRLTPNITAGH 168
Cdd:MTH00173  92 PFVFSVTSHLAFTFSLALPLWLSLILSGLFYNPSKSLAGLVPAGAPAGLNPFLVLIETVSILIRPLTLTVRLLANISAGH 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 74310592  169 LLMTMISSAALSFINMYNTLSIMTMMLLMLLTLL-EMAVACIQAYVFILLITLYLQE 224
Cdd:MTH00173 172 IVLTLIGNYLSSSLFSSSVVSLLLVLLIQVGYFIfEVAVMLIQAYIFTLLIKLYSDE 228
ATP-synt_Fo_a_6 cd00310
ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms ...
 85-223 5.32e-31

ATP synthase Fo complex, subunit 6 (eukaryotes) and subunit a (prokaryotes); Bacterial forms are designated as ATP synthase, Fo complex, subunit a; eukaryotic (chloroplast and mitochondrial) forms are designated as ATP synthase, Fo complex, subunit 6. The F-ATP synthases (also called FoF1-ATPases) consist of two structural domains: F1 (factor one) complex containing the soluble catalytic core, and Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. F-ATP synthase has also been found in the archaea Methanosarcina acetivorans. F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis.


Pssm-ID: 349411 [Multi-domain]  Cd Length: 156  Bit Score: 111.34  E-value: 5.32e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592  85 LGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRLTPNI 164
Cdd:cd00310  21 LGLIPYSFTPTSHLNVTLALALIVFLGVHILGIKKHGLGFFLHFLPPGTPLPLAPLMVPIELISELIRPLSLSVRLFANM 100

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 74310592 165 TAGHLLMTMISSAALSFINMyntLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQ 223
Cdd:cd00310 101 FAGHLLLALLSGLVPSLLSS---VGLLPLLLPVALTLLELFVAFIQAYVFTLLTAVYIS 156
ATP6 MTH00176
ATP synthase F0 subunit 6; Provisional
 1-226 5.00e-28

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214449  Cd Length: 229  Bit Score: 105.89  E-value: 5.00e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPILLIYTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQK---WSRFLMSLLL 77
Cdd:MTH00176   1 MLVDLFSSFDPPNKNIFSMISLSWITLLLFLLLMPSSVWFCPSKLQVFMLMFSTFLPEMILRSNGSYilgSASIIISLFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   78 LILLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALG 157
Cdd:MTH00176  81 LVMSLNLSGLIPYVFTSTSHLVITLSLALPLWLGVILSGFINNFYSRLSHLVPQGTPPLLNPFLVLIELVSLLIRPLTLA 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 74310592  158 VRLTPNITAGHLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQENT 226
Cdd:MTH00176 161 VRLAANLSAGHLLLGLLGAAMWGLLPVSPLIGFLLLIVQILYFMFEIAVCMIQAYVFTLLLSLYLDEHP 229
ATP-synt_A pfam00119
ATP synthase A chain;
89-223 1.54e-26

ATP synthase A chain;


Pssm-ID: 459679 [Multi-domain]  Cd Length: 216  Bit Score: 101.80  E-value: 1.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    89 PYTFTTTSQLSMNMAFAIPMWLGTVITGL-TMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRLTPNITAG 167
Cdd:pfam00119  81 PGGFTVTADINVTLALALIVFLLVHYYGIkKHGLGGYFKKLFVPPVPLPLVPLLLPIEIISEFARPVSLSLRLFGNMLAG 160

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 74310592   168 HLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQ 223
Cdd:pfam00119 161 HLLLLLLAGLIFALLSAGFLLGVIPPLLGVAWTLFELLVAFIQAYVFTMLTAVYIS 216
ATP6 MTH00172
ATP synthase F0 subunit 6; Provisional
 1-222 2.37e-24

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 214447  Cd Length: 232  Bit Score: 96.26  E-value: 2.37e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    1 MNLNMFEQFASPEILLLPTNIMSMLIPI---LLIYTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLL 77
Cdd:MTH00172   1 MSSSYFDQFNIVWLIGLTNSSIMMILVIivvLLLFKGIKLIPKRWQSIIEIIYNHFHGVVKDNLGNEGLKYFPFIISLFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   78 LILLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALG 157
Cdd:MTH00172  81 FIVFLNLLGLFPYVFTPTTHIVVTLGLSFSIIIGVTLAGFWRFKWDFFSILMPSGAPLGLAPLLVLIETVSYISRAISLG 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 74310592  158 VRLTPNITAGHLLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYL 222
Cdd:MTH00172 161 VRLAANLSAGHLLFAILAGFGFNMLCASGFLSLFPLLIMVFITLLEIAVAVIQAYVFCLLTTIYL 225
ATP6 MTH00005
ATP synthase F0 subunit 6; Provisional
 9-226 4.01e-24

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 164583  Cd Length: 231  Bit Score: 95.57  E-value: 4.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592    9 FASPEILLLPTNIMSMLIPILLIYTKPtllgNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLILLSNLLGLL 88
Cdd:MTH00005  18 NNLSSTAFWAFNFSIILLLSSSFWITP----NRLSSIMSPPKSTMHTQLSRTFGKHLKGFSSLISALFTMIILMNLSGLL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   89 PYTFTTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRLTPNITAGH 168
Cdd:MTH00005  94 PYVFSTSSHLIFTLTLGLPLWLSLIMSSVTFSPKKFAAHLLPGGAPDWLNPFLVLIETISILVRPITLSFRLAANMSAGH 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 74310592  169 LLMTMISSAALSFINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQENT 226
Cdd:MTH00005 174 IVLSLIGIYAASALFSSISSTILLILTQMGYILFEVGICLIQAYIFCLLLSLYSDDHP 231
ATP6 MTH00175
ATP synthase F0 subunit 6; Provisional
 21-222 1.57e-22

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177228  Cd Length: 244  Bit Score: 91.61  E-value: 1.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   21 IMSMLIPILLIYTKPTLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLILLSNLLGLLPYTFTTTSQLSM 100
Cdd:MTH00175  35 MVLAVIIFWLLLKGDKLIPNRWQSIMELIYLNIRSVVHDNLGKSGQKYFPFILSLFLFIAILNILGLFPYVFTPTAHIII 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592  101 NMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRLTPNITAGHLLMTMISSAALS 180
Cdd:MTH00175 115 TFGLSLSIIIAVTLLGFLTFKWNFLSILMPGGAPLVLAPFLVLIETLSYLIRAISLGVRLAANISAGHLLFAILSGFAFN 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 74310592  181 -FINMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYL 222
Cdd:MTH00175 195 mLSNGLIILSLFPMLIMIFITLLEMAVAVIQAYVFCLLTTIYL 237
ATP6 MTH00174
ATP synthase F0 subunit 6; Provisional
 36-224 4.70e-16

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 133799  Cd Length: 252  Bit Score: 74.59  E-value: 4.70e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   36 TLLGNRISTILNWFLKTALSNMINQLSLAGQKWSRFLMSLLLLILLSNLLGLLPYTFTTTSQLSMNMAFAIPMWLGTVIT 115
Cdd:MTH00174  58 TLVPNRILVGLELIYSHFYTVLKDNLGNKGGNYLAFVLSLFILILFGNGLGLFPYVFTPTVHMVITLGLSFAIIVGTTLA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592  116 GLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRLTPNITAGHLLMTMISSAALSFINMYNTL-SIMTMM 194
Cdd:MTH00174 138 GLITFRFNFFSILMPQGAPLALAPLLTIIETLSYISRAISLGVRLAANISSGHLLFSIIASFAWKMINTGILIgSFVPFA 217

                        170       180       190
                 ....*....|....*....|....*....|
gi 74310592  195 LLMLLTLLEMAVACIQAYVFILLITLYLQE 224
Cdd:MTH00174 218 ILIFVTILEMAVAIIQAYVFTLLTIVYLRD 247
AtpB COG0356
FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP ...
 89-224 1.93e-15

FoF1-type ATP synthase, membrane subunit a [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit a is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440125 [Multi-domain]  Cd Length: 212  Bit Score: 72.03  E-value: 1.93e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592  89 PYTFTTTSQLSMNMAFAIPMWLGTVITGLTMK-TSSSLAHMLPEGSPtPLIPFMILIETISLLMRPIALGVRLTPNITAG 167
Cdd:COG0356  78 PGLFPPTADINVTLALALIVFVLVHYYGIKKKgLGGYLKHLFFPPFP-WLAPLMLPIEIISELARPLSLSLRLFGNMFAG 156

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 74310592 168 HLLMTMISSAALSFinmynTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQE 224
Cdd:COG0356 157 HIILLLLAGLAPFL-----LLGVLSLLLPVAWTAFELLVGFLQAYIFTMLTAVYISL 208
PRK05815 PRK05815
F0F1 ATP synthase subunit A; Validated
 90-224 1.37e-13

F0F1 ATP synthase subunit A; Validated


Pssm-ID: 235617  Cd Length: 227  Bit Score: 67.13  E-value: 1.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   90 YTFTTTSQLSMNMAFAIPMWLGTVITGLTMKtssSLAHMLPEGSPTPlIPFMILIETISLLMRPIALGVRLTPNITAGHL 169
Cdd:PRK05815  95 LLFPPTADINVTLALALIVFVLVIYYGIKKK---GLGGYLKEFYLQP-HPLLLPIEIISEFSRPISLSLRLFGNMLAGEL 170

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 74310592  170 LMTMISSAALSFInmynTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQE 224
Cdd:PRK05815 171 ILALIALLGGAGL----LLALAPLILPVAWTIFEIFVGTLQAYIFMMLTIVYISM 221
ATP6 MTH00087
ATP synthase F0 subunit 6; Provisional
 89-224 1.56e-12

ATP synthase F0 subunit 6; Provisional


Pssm-ID: 177152  Cd Length: 195  Bit Score: 63.84  E-value: 1.56e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   89 PYTFTTTSQLSMNMAFAIPMWLGTVITglTMKTSSSLAHMLPEGSPTPLIPF-MILIETISLLMRPIALGVRLTPNITAG 167
Cdd:MTH00087  72 PYSFSPCGMVEFTFLYALVAWLSTFLS--FLSKSEKFSVYLSKGSDSFLKTFsMLFVEIVSELSRPLALTLRLTVNLMVG 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 74310592  168 HLLMTMIssaalsfinmyNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYLQE 224
Cdd:MTH00087 150 HLISSLL-----------NFLGEKYVWLSILAIMMECFVAFIQSYIFSRLIYLYLNE 195
PRK13417 PRK13417
F0F1 ATP synthase subunit A; Provisional
 93-222 4.07e-09

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237380  Cd Length: 352  Bit Score: 55.67  E-value: 4.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   93 TTTSQLSMNMAFAIPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETI-SLLMRPIALGVRLTPNITAGHLLM 171
Cdd:PRK13417 217 TVTGDISVTMTLALLTMFLIYGAGFSYQGPKFIWHSVPNGVPLLLYPIMWPLEFIvSPMAKTFALTVRLLANMTAGHVII 296

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 74310592  172 TmissAALSFINMYNTLSIMTMMLLMLLTL--LEMAVACIQAYVFILLITLYL 222
Cdd:PRK13417 297 L----ALMGFIFQFQSWGIVPVSVIGSGLIyvLEIFVAFLQAYIFVLLTSLFV 345
PRK13419 PRK13419
F0F1 ATP synthase subunit A; Provisional
 89-222 8.41e-09

F0F1 ATP synthase subunit A; Provisional


Pssm-ID: 237381  Cd Length: 342  Bit Score: 54.75  E-value: 8.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592   89 PYTFTTTSQLSMNMAFAIPMWLGTVITGL-TMKTSSSLAHmLPEGSPTPLIPFMILIETISLLMRPIALGVRLTPNITAG 167
Cdd:PRK13419 191 PYGATATGNINVTLTLAVFTFFITQYAAIkAHGIKGYLAH-LTGGTHWSLWIIMIPIEFIGLFTKPFALTVRLFANMTAG 269

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 74310592  168 HLLmtMISSAALSFI-NMYNTLSIMTMMLLMLLTLLEMAVACIQAYVFILLITLYL 222
Cdd:PRK13419 270 HIV--ILSLIFISFIlKSYIVAVAVSVPFAIFIYLLELFVAFLQAYIFTMLSALFI 323
ATP6 MTH00050
ATP synthase F0 subunit 6; Validated
 106-185 9.52e-04

ATP synthase F0 subunit 6; Validated


Pssm-ID: 177125  Cd Length: 170  Bit Score: 38.71  E-value: 9.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 74310592  106 IPMWLGTVITGLTMKTSSSLAHMLPEGSPTPLIPFMILIETISLLMRPIALGVRLTPNITAGHLLMTMISSaaLSFINMY 185
Cdd:MTH00050  60 FPLFISLFLSRVFDSLNEFFSSFVPVGTPLYICPFVCIAETISYIIRPVVLILRPFINISLGCFGGVALGN--LCFISYW 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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