|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
3-774 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1166.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 3 LHVIRRDGSRKEVHLHDIKAGIETLCFNLNKQYVNAAVVALNIMKGIRPGITTEELNVYAADVVASMTYIHHDFAVLAGR 82
Cdd:PLN02437 1 MYVVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 83 ILVDDLHNKIDASFSEVVFNLHRHK---------LVSDELASVVESHGDEINEAIDHAVDYTYKFFGYKTLENGYLLKID 153
Cdd:PLN02437 81 IAVSNLHKNTKKSFSETVKDMYNHVnersglkapLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 154 NQVAERPQHMLMRVALGIHGDDIQDAIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIRSDSIDGIYETLGDCAA 233
Cdd:PLN02437 161 GKVVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 234 ISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGG-KRKGALAVYIEPWHADIYSVLNLKRNMGA 312
Cdd:PLN02437 241 ISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGgKRKGAFAIYLEPWHADIFEFLDLRKNHGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 313 EDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYEEEGRYQQQVRAQDLHRFIVETQVET 392
Cdd:PLN02437 321 EEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIET 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 393 GGPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVQYSDAEETAVCNLASIAVNSCVVVD------------------EARF 454
Cdd:PLN02437 401 GTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVREKgvpleshpsklvgslgskNRYF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 455 DFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALE 534
Cdd:PLN02437 481 DFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 535 ASCELAKTWGSYSSFQGSPASEGILQYDMWDVRPTSLWDWGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPFT 614
Cdd:PLN02437 561 ASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 615 SNVYLRRVLAGEFQVVNQYLIDDLIKLKLYTSEMRNAIFAHKGSIQAIDGIPDHIKRLYKTAWEMKCKRMIEMAADRNAF 694
Cdd:PLN02437 641 SNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 695 IDQSQSLNLFVAEPTYALMTSIHDYTWRSGLKTGMYYLRTKPAAHTQQFTVEQQFTVERGDVCKKRKINNYDEDAAQNVC 774
Cdd:PLN02437 721 IDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATGVAAPEEEDVETKMAQMVC 800
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
95-747 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 743.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 95 SFSEVVfNLHRHKLVSDELAsvvESHGDEINEAIDHAVDYTYKFFGYKTLENGYLLK-IDNQVAERPQHMLMRVALGIH- 172
Cdd:COG0209 12 SFSEKI-KYVEEGLYDERLL---EEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKdEDGKPLETPQDLFMRVAMGLAa 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 173 ----GDDIQDAIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIrSDSIDGIYETLGDCAAISKYGGGLGVNVHCV 248
Cdd:COG0209 88 aekpEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKDAALLSKSGGGVGFNFSRL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 249 RSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPD 328
Cdd:COG0209 167 RPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 329 LFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYEEEGRYQQQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSN 408
Cdd:COG0209 247 LFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAWETGEPGILFKDTINRRNP 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 409 QQNLGTIKCSNLCAEIVQYSDAEETAVCNLASIavNSCVVVDEARFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSN 488
Cdd:COG0209 327 LPHLGVIHSSNLCGEIPLLPYESEDASCNLGSI--NLAKFVKDGEFDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKAN 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 489 MKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQGSPASEGILQYDMW--DV 566
Cdd:COG0209 405 RRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKGILPFDKYldDL 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 567 RPTSLWDWGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPFTSNVYLRRVL-AGEFQVVNQYLIDDLIKLKLYT 645
Cdd:COG0209 485 LIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLdGGEFTVVNPYLVRALKELGLWD 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 646 SEMRNAIfAHKGSIQAIDGIPDHIKRLYKTAWEMKCKRMIEMAADRNAFIDQSQSLNLFVA-EPTYALMTSIHDYTWRSG 724
Cdd:COG0209 565 EELVEKI-KEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPnDATVEDLAELYLLAWKLG 643
|
650 660
....*....|....*....|...
gi 90592870 725 LKTgMYYLRTKPAAHTQQFTVEQ 747
Cdd:COG0209 644 LKG-IYYYRDGSRTGQVLSTGKK 665
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
138-735 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 668.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 138 FFGYKTLENGYLLKI--DNQVAERPQHMLMRVALGIHG-----DDIQDAIETYRMMSRKMFTHASPTLFSAGTPMAQMCS 210
Cdd:TIGR02506 1 YMGLKELYNRYLLRNaaTGAIYESPQEAYMRVAMGLASlepkdTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 211 CFLLGIRSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALA 290
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 291 VYIEPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYEEEG 370
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 371 RYQQ---QVRAQDLHRFIVETQVETGGPYMLYKDACNRK-SNQQNLGTIKCSNLCAEIVQYSDAE---ETAVCNLASIAV 443
Cdd:TIGR02506 241 EARKkirKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVNL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 444 NSCVVVDEarFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQ 523
Cdd:TIGR02506 321 ANFVMEDK--FDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 524 IAETIYFGALEASCELAKTWGSYSSFQGSPASEGILQYDMWDVRPTSLW-------DWGTLKEDIKKHGLRNSLLVAYMP 596
Cdd:TIGR02506 399 IFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 597 TATTAQILGNNESFEPFTSNVYLRRVLAGEFQVVNQYLIDDLIKLKLYTSEMRNAIFAHKGSIQAIDGIPDHIKRLYKTA 676
Cdd:TIGR02506 479 TASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTA 558
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 677 WEMKCKRMIEMAADRNAFIDQSQSLNLFVAE-PTYALMTSIHDYTWRSGLKTgMYYLRTK 735
Cdd:TIGR02506 559 YELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
210-731 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 662.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 210 SCFLLGIRsDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGAL 289
Cdd:pfam02867 2 SCFLLSVE-DSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 290 AVYIEPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYEE- 368
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEYYEREEn 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 369 EGRYQQQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVQYSDAEETAVCNLASIAVNSCvV 448
Cdd:pfam02867 161 EGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF-V 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 449 VDEARFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETI 528
Cdd:pfam02867 240 EFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFETM 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 529 YFGALEASCELAKTWGSYSSFQGSPASEGILQYDMWDVR------PTSLWDWGTLKEDIKKHGLRNSLLVAYMPTATTAQ 602
Cdd:pfam02867 320 YYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTdfapkaSKTREDWEELREDIKKYGLRNSQLTAIAPTGSISQ 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 603 ILGNNESFEPFTSNVYLRRVLAgefqvvnqyliddliklklytsemrnaifahkgsiqaidgipDHIKRLYKTAWEMKCK 682
Cdd:pfam02867 400 IAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQK 437
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 90592870 683 RMIEMAADRNAFIDQSQSLNLFV-AEPTYALMTSIHDYTWRSGLKTGMYY 731
Cdd:pfam02867 438 AHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
160-734 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 622.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 160 PQHMLMRVALGIHGDDIQDAIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIRsDSIDGIYETLGDCAAISKYGG 239
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVD-DSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 240 GLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIYSVLNLKRNMGAEDCKARD 319
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 320 LMYALWVPDLFMERVnangvwslmcpnkcpglsdcygsafeelyrkyeeegryqqqvrAQDLHRFIVETQVETGGPYMLY 399
Cdd:cd01679 160 LFYGVWIPDLFMERV-------------------------------------------ERDLWRKILESQFETGYPYILF 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 400 KDACNRKSNQQNLGTIKCSNLCAEIVQYSDA-----EETAVCNLASIAVnscvvvdeARFD-FEKLRHITKVVVRNLNKI 473
Cdd:cd01679 197 KDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINL--------GNFVtFEKLEEVVKLAVRALDNV 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 474 IDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGsyssfqgsp 553
Cdd:cd01679 269 IDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG--------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 554 asegilqydmwdvrptslwdwgtlkedikkhGLRNSLLVAYMPTATTAQILGNNESFEPFTSNVYLRRVLAGEFQVVNQY 633
Cdd:cd01679 340 -------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNPH 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 634 LIDDLIKLklytsemrnaifahkgsiqaidgipdhikRLYKTAWEMKCKRMIEMAADRNAFIDQSQSLNLFVAEP-TYAL 712
Cdd:cd01679 389 LEKDLWEY-----------------------------GLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTRD 439
|
570 580
....*....|....*....|..
gi 90592870 713 MTSIHDYTWRSGLKTGmYYLRT 734
Cdd:cd01679 440 LNSLYFYAWKKGLKTL-YYLRT 460
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
3-774 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1166.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 3 LHVIRRDGSRKEVHLHDIKAGIETLCFNLNKQYVNAAVVALNIMKGIRPGITTEELNVYAADVVASMTYIHHDFAVLAGR 82
Cdd:PLN02437 1 MYVVKRDGRQETVHFDKITARLKKLSYGLSQDHCDPVLVAQKVCAGVYKGVTTSQLDELAAETAAAMTTNHPDYAILAAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 83 ILVDDLHNKIDASFSEVVFNLHRHK---------LVSDELASVVESHGDEINEAIDHAVDYTYKFFGYKTLENGYLLKID 153
Cdd:PLN02437 81 IAVSNLHKNTKKSFSETVKDMYNHVnersglkapLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 154 NQVAERPQHMLMRVALGIHGDDIQDAIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIRSDSIDGIYETLGDCAA 233
Cdd:PLN02437 161 GKVVERPQHMLMRVSVGIHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 234 ISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGG-KRKGALAVYIEPWHADIYSVLNLKRNMGA 312
Cdd:PLN02437 241 ISKSAGGIGLSVHNIRATGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGgKRKGAFAIYLEPWHADIFEFLDLRKNHGK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 313 EDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYEEEGRYQQQVRAQDLHRFIVETQVET 392
Cdd:PLN02437 321 EEHRARDLFYALWIPDLFMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIET 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 393 GGPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVQYSDAEETAVCNLASIAVNSCVVVD------------------EARF 454
Cdd:PLN02437 401 GTPYMLFKDSCNRKSNQQNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVREKgvpleshpsklvgslgskNRYF 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 455 DFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALE 534
Cdd:PLN02437 481 DFEKLAEVTAVVTRNLNKIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALK 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 535 ASCELAKTWGSYSSFQGSPASEGILQYDMWDVRPTSLWDWGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPFT 614
Cdd:PLN02437 561 ASSELAAREGPYETYAGSPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYT 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 615 SNVYLRRVLAGEFQVVNQYLIDDLIKLKLYTSEMRNAIFAHKGSIQAIDGIPDHIKRLYKTAWEMKCKRMIEMAADRNAF 694
Cdd:PLN02437 641 SNIYSRRVLSGEFVVVNKHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCY 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 695 IDQSQSLNLFVAEPTYALMTSIHDYTWRSGLKTGMYYLRTKPAAHTQQFTVEQQFTVERGDVCKKRKINNYDEDAAQNVC 774
Cdd:PLN02437 721 IDQSQSLNIHMDQPNFGKLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATGVAAPEEEDVETKMAQMVC 800
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
95-747 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 743.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 95 SFSEVVfNLHRHKLVSDELAsvvESHGDEINEAIDHAVDYTYKFFGYKTLENGYLLK-IDNQVAERPQHMLMRVALGIH- 172
Cdd:COG0209 12 SFSEKI-KYVEEGLYDERLL---EEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKdEDGKPLETPQDLFMRVAMGLAa 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 173 ----GDDIQDAIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIrSDSIDGIYETLGDCAAISKYGGGLGVNVHCV 248
Cdd:COG0209 88 aekpEDREEWAKEFYDLLSSLRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKDAALLSKSGGGVGFNFSRL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 249 RSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPD 328
Cdd:COG0209 167 RPKGSPIKGTGGVSSGPVPFMKVFDDAAVAVNQGGKRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 329 LFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYEEEGRYQQQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSN 408
Cdd:COG0209 247 LFMEAVEEDEDWTLFSPREVPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAWETGEPGILFKDTINRRNP 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 409 QQNLGTIKCSNLCAEIVQYSDAEETAVCNLASIavNSCVVVDEARFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSN 488
Cdd:COG0209 327 LPHLGVIHSSNLCGEIPLLPYESEDASCNLGSI--NLAKFVKDGEFDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKAN 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 489 MKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQGSPASEGILQYDMW--DV 566
Cdd:COG0209 405 RRHRPIGLGVMGLADALAKLGIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKGILPFDKYldDL 484
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 567 RPTSLWDWGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPFTSNVYLRRVL-AGEFQVVNQYLIDDLIKLKLYT 645
Cdd:COG0209 485 LIPTTLDWDALREDIKKHGLRNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLdGGEFTVVNPYLVRALKELGLWD 564
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 646 SEMRNAIfAHKGSIQAIDGIPDHIKRLYKTAWEMKCKRMIEMAADRNAFIDQSQSLNLFVA-EPTYALMTSIHDYTWRSG 724
Cdd:COG0209 565 EELVEKI-KEDGSVQDIDELPEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPnDATVEDLAELYLLAWKLG 643
|
650 660
....*....|....*....|...
gi 90592870 725 LKTgMYYLRTKPAAHTQQFTVEQ 747
Cdd:COG0209 644 LKG-IYYYRDGSRTGQVLSTGKK 665
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
138-735 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 668.70 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 138 FFGYKTLENGYLLKI--DNQVAERPQHMLMRVALGIHG-----DDIQDAIETYRMMSRKMFTHASPTLFSAGTPMAQMCS 210
Cdd:TIGR02506 1 YMGLKELYNRYLLRNaaTGAIYESPQEAYMRVAMGLASlepkdTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 211 CFLLGIRSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALA 290
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGGKRPGAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 291 VYIEPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYEEEG 370
Cdd:TIGR02506 161 VYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKDV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 371 RYQQ---QVRAQDLHRFIVETQVETGGPYMLYKDACNRK-SNQQNLGTIKCSNLCAEIVQYSDAE---ETAVCNLASIAV 443
Cdd:TIGR02506 241 EARKkirKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVNL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 444 NSCVVVDEarFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQ 523
Cdd:TIGR02506 321 ANFVMEDK--FDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 524 IAETIYFGALEASCELAKTWGSYSSFQGSPASEGILQYDMWDVRPTSLW-------DWGTLKEDIKKHGLRNSLLVAYMP 596
Cdd:TIGR02506 399 IFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 597 TATTAQILGNNESFEPFTSNVYLRRVLAGEFQVVNQYLIDDLIKLKLYTSEMRNAIFAHKGSIQAIDGIPDHIKRLYKTA 676
Cdd:TIGR02506 479 TASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTA 558
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 677 WEMKCKRMIEMAADRNAFIDQSQSLNLFVAE-PTYALMTSIHDYTWRSGLKTgMYYLRTK 735
Cdd:TIGR02506 559 YELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
210-731 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 662.75 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 210 SCFLLGIRsDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGAL 289
Cdd:pfam02867 2 SCFLLSVE-DSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGGKRRGAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 290 AVYIEPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYEE- 368
Cdd:pfam02867 81 AVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEYYEREEn 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 369 EGRYQQQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVQYSDAEETAVCNLASIAVNSCvV 448
Cdd:pfam02867 161 EGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF-V 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 449 VDEARFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETI 528
Cdd:pfam02867 240 EFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFETM 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 529 YFGALEASCELAKTWGSYSSFQGSPASEGILQYDMWDVR------PTSLWDWGTLKEDIKKHGLRNSLLVAYMPTATTAQ 602
Cdd:pfam02867 320 YYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTdfapkaSKTREDWEELREDIKKYGLRNSQLTAIAPTGSISQ 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 603 ILGNNESFEPFTSNVYLRRVLAgefqvvnqyliddliklklytsemrnaifahkgsiqaidgipDHIKRLYKTAWEMKCK 682
Cdd:pfam02867 400 IAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQK 437
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 90592870 683 RMIEMAADRNAFIDQSQSLNLFV-AEPTYALMTSIHDYTWRSGLKTGMYY 731
Cdd:pfam02867 438 AHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
160-734 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 622.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 160 PQHMLMRVALGIHGDDIQDAIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIRsDSIDGIYETLGDCAAISKYGG 239
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTVD-DSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 240 GLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIYSVLNLKRNMGAEDCKARD 319
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGGQRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRARD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 320 LMYALWVPDLFMERVnangvwslmcpnkcpglsdcygsafeelyrkyeeegryqqqvrAQDLHRFIVETQVETGGPYMLY 399
Cdd:cd01679 160 LFYGVWIPDLFMERV-------------------------------------------ERDLWRKILESQFETGYPYILF 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 400 KDACNRKSNQQNLGTIKCSNLCAEIVQYSDA-----EETAVCNLASIAVnscvvvdeARFD-FEKLRHITKVVVRNLNKI 473
Cdd:cd01679 197 KDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINL--------GNFVtFEKLEEVVKLAVRALDNV 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 474 IDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGsyssfqgsp 553
Cdd:cd01679 269 IDLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG--------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 554 asegilqydmwdvrptslwdwgtlkedikkhGLRNSLLVAYMPTATTAQILGNNESFEPFTSNVYLRRVLAGEFQVVNQY 633
Cdd:cd01679 340 -------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNPH 388
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 634 LIDDLIKLklytsemrnaifahkgsiqaidgipdhikRLYKTAWEMKCKRMIEMAADRNAFIDQSQSLNLFVAEP-TYAL 712
Cdd:cd01679 389 LEKDLWEY-----------------------------GLYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTRD 439
|
570 580
....*....|....*....|..
gi 90592870 713 MTSIHDYTWRSGLKTGmYYLRT 734
Cdd:cd01679 440 LNSLYFYAWKKGLKTL-YYLRT 460
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
2-745 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 569.98 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 2 QLHVIRRDGSRKEVHLHDIKAGIETLCFNLNkqYVNAAVVALNIMKGIRPGITTEElnVYAADVVASMTYIHHD--FAVL 79
Cdd:PRK07207 148 GLNVTLDDGVRRPLDMARLRALIEEACEGLE--AVDAEPILAETLKNLYDGVPMDE--VYKALILAARTLIEKEpnYSYV 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 80 AGRILVDDLHNKI--------DASFSEVV---------FnLHR---HKLVSDELAsvvESHGDEINEAIDHAVDYTYKFF 139
Cdd:PRK07207 224 TARLLLDTLRREAlgflgvpeEVTQAEMAtryaeyfpaF-IKKgieAELLDPKLA---QFDLERLGAALDPERDLQFTYL 299
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 140 GYKTLENGYLLKIDNQVAERPQHMLMRVALG--IHGDDIQD-AIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGI 216
Cdd:PRK07207 300 GLQTLYDRYFLHVDGTRIELPQAFFMRVAMGlaLNEIDREArAIEFYNLLSSFDFMSSTPTLFNSGTLRPQLSSCYLTTV 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 217 rSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPW 296
Cdd:PRK07207 380 -PDDLDGIYEAIKDNALLSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPFLKVVNDTAVAVNQGGKRKGAVCAYLETW 458
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 297 HADIYSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYEEEGRYQQ-- 374
Cdd:PRK07207 459 HLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSEVPDLHDLFGKAFEEAYTAYEAKAARGEik 538
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 375 ---QVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVQYSDAEETAVCNLASI-AVNScvVVD 450
Cdd:PRK07207 539 lfkKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQQHVGVVHSSNLCTEITLNTSDDEIAVCNLGSVnLVAH--IKD 616
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 451 EARFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYF 530
Cdd:PRK07207 617 GAKLDHEKLKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQDALYLLRIPYASDEAVEFADRSMEAVSY 696
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 531 GALEASCELAKTWGSYSSFQGSPASEGILQYD-----------MWDVRPTSLWDWGTLKEDIKKHGLRNSLLVAYMPTAT 599
Cdd:PRK07207 697 YAIWASTELAEERGRYSSYEGSLWSRGILPIDslkllaearggYLEVDRSSTLDWDALRARIKKHGMRNSNCMAIAPTAT 776
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 600 TAQILGNNESFEPFTSNVYLRRVLAGEFQVVNQYLIDDLIKLKLYTSEMRNAIFAHKGSIQAIDGIPDHIKRLYKTAWEM 679
Cdd:PRK07207 777 ISNIIGVSQSIEPTYQNLYVKSNLSGEFTVVNPYLVRDLKARGLWDEVMVNDLKYFDGSLQRIDRIPADLKALYATAFEV 856
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90592870 680 KCKRMIEMAADRNAFIDQSQSLNLFVAEPTYALMTSIHDYTWRSGLKTgMYYLRTKPAAHTQQFTV 745
Cdd:PRK07207 857 DPRWLVEAASRRQKWIDQAQSLNLYMAGASGKKLDETYKLAWLRGLKT-TYYLRTLGATHVEKSTV 921
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
5-750 |
2.32e-157 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 484.84 E-value: 2.32e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 5 VIRRDGSRKEVHLHDIKAGIETLCFNLNKQyVNAAVVA----LNIMKGIRpgitteELNVYAADVVASMTYIHH--DFAV 78
Cdd:PRK12365 238 VLSKDGSTYTMTKSQLLAHFAWACSRFPET-TDAALLAdmafANFYSGIK------ESEVVLACIMAARANIEKepDYAF 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 79 LAGRILVDDLH------NKIDASFSEVVFNLHRHKLVSDEL----ASVVESHGDEINEAIDHAVDYTYKFFGYKTLENGY 148
Cdd:PRK12365 311 VAAELLLDVVYkealgkSKYDEDLEEAHKDHFKRYILEGDTyrlnPELKHYDLDALAEALDLSRDLQFSYMGVQNLYDRY 390
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 149 LLKIDNQVAERPQHMLMRVALGIHGDDIQD----AIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIRsDSIDGI 224
Cdd:PRK12365 391 FNHHEGRRLETPQIFWMRVSMGLALNEGQDktswAITFYNLLSTFRYTPATPTLFNSGMRHSQLSSCYLSTVQ-DDLVHI 469
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 225 YETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIYSVL 304
Cdd:PRK12365 470 YKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAVAVNQGGKRKGAVCVYLEVWHLDYEDFL 549
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 305 NLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYEE-----EGRYQQQVRAQ 379
Cdd:PRK12365 550 ELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAYGEEFEKLYEEYERkvdtgEIRLYKKVEAE 629
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 380 DLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVQYSDAEETAVCNLASIAVNSCVVVDEarFDFEKL 459
Cdd:PRK12365 630 DLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLNCSETETAVCNLGSINLVEHIVNDG--LDEEKL 707
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 460 RHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCEL 539
Cdd:PRK12365 708 SETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISYASQEAVEFADYSSELIAYYAILASSLL 787
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 540 AKTWGSYSSFQGSPASEGILQYDMWD------------VRPTSLWDWGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNN 607
Cdd:PRK12365 788 AKERGTYSSYKGSKWDRGYLPIDTIEllkeyrgeanllMDTSSRKDWEPVRSLIKEYGMRNSQLMAIAPTATISNIIGVT 867
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 608 ESFEPFTSNVYLRRVLAGEFQVVNQYLIDDLIKLKLYTSEMRNAIFAHKGSIQAIDGIPDHIKRLYKTAWEMKCKRMIEM 687
Cdd:PRK12365 868 QSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADMLDDLKYFDGSLLEIERIPDHLKKIFLTAFEIEPEWIIEC 947
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90592870 688 AADRNAFIDQSQSLNLFVAEPTYALMTSIHDYTWRSGLKTgMYYLRTKPAAhtqqfTVEQQFT 750
Cdd:PRK12365 948 ASRRQKWIDMGQSLNLYLAEPDGKKLSNMYLTAWKKGLKT-TYYLRSSAAT-----SVEKSFV 1004
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-745 |
2.05e-135 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 420.87 E-value: 2.05e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 1 MQLHVIRRDGSRKEVHLHDIKAGIETLCFNLNKQYVNAAVVALNIMKGIRPGITTEELNVYAADVVASMTYIHHDFAVLA 80
Cdd:PRK06539 1 MSITVVKRDGSKEPYDANKVNAAIEDAARGLDDAITWVTQLASELEITLFDGITTQQLDEAVIQVALQNVKDDPAFDTVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 81 GRILVDDLHNKI--DASFSEVVFNLHRHKLVSDELASVVESHGDE----------INEAIDHAVDYTYKFFGYKTLENGY 148
Cdd:PRK06539 81 ARLLLKKIYKRVlgDYDSPEELQDLHANHFRRTIEKGVAEGLLDSrlgglfdlerLAAALDPTRDELLKYIGVVTLNNRY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 149 LLKI-DNQVAERPQHMLMRVALGI---HGDDIQDAIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIRsDSIDGI 224
Cdd:PRK06539 161 GIRArNGDALEVPQYFWMRIAMGLslnEDDPTSSALAFYEKMSKLEYLAAGSTLVNAGTPYPQLSNCFVMEMQ-DDIEHI 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 225 YETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIYSVL 304
Cdd:PRK06539 240 AKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLRAVSRGGKKFGALCFYMENWHMDFPEFL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 305 NLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKY---EEEGRYQ--QQVRAQ 379
Cdd:PRK06539 320 DLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYGKAFSKRYAQYveqAEAGRIRmfKRITAR 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 380 DLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVQYSDAEETAVCNLASIAVNSCVVvdEARFDFEKL 459
Cdd:PRK06539 400 EQFRAILMSLQTTSHPWLTWKDTINNRALNNNTGTIHLSNLCTEICLPQDRDNVSVCNLASINLSRHLA--DGELDWAQL 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 460 RHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCEL 539
Cdd:PRK06539 478 EESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSYESEEAYDLIDRIMEHISYAAIDESADL 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 540 AKTWGSYSSFQGSPASEGILQYDMW-----------DVRPTSLWDWGTLKEDIKKhGLRNSLLVAYMPTATTAQILGNNE 608
Cdd:PRK06539 558 AAERGAYPNFEGSRWSRGMVPVDSIalleadrgvpvDVNRTTRLDWDALRAKVRG-GMRNATLMAIAPTASIGLVAGTTP 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 609 SFEPFTSNVYLRRVLAGEFQVVNQYLIDDLIKLKLYtSEMRNAIFAHKGSIQAIDGIPDHIKRLYKTAWEMKCKRMIEMA 688
Cdd:PRK06539 637 GLDPQFSQIFSRSTSSGKFLEVNRNLVADLKELGLW-ETVREEILRSQGDIQEIAAIPDEIKALYRTSFQLSPYAFLEVA 715
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*..
gi 90592870 689 ADRNAFIDQSQSLNLFVAEPTYALMTSIHDYTWRSGLKTgMYYLRTKPAAHTQQFTV 745
Cdd:PRK06539 716 ARAQKWVDQAISRNMYLESRDIGDMMDIYTAAWEMGVKT-TYYLHMKPRHTAEQSTV 771
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
122-734 |
2.64e-112 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 358.66 E-value: 2.64e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 122 DEINEA---IDHAVDYTYKFFGYKTLENGYLLK-IDNQVAERPQHMLMRVALGIHGDDIQD-----AIETYRMMSRKMFT 192
Cdd:PRK09209 139 EELIEAgkmIDPERDKLFTYIGLYLLADRYLATdSDRNVYELPQERWLTIALYLMQNEPRErrmqlVKEAYWALSNLYMT 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 193 HASPTLFSAGTPMAQMCSCFLLGIrSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVF 272
Cdd:PRK09209 219 VATPTLANAGKVGGQLSSCFIDTV-DDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQL 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 273 NNMVRHVDQGGKRKGALAVYIEPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCP--- 349
Cdd:PRK09209 298 NNTAVSVDQLGQRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKkvm 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 350 --GLSDCY-----GSAFEElyrKYEE----EGRYQQQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCS 418
Cdd:PRK09209 378 gwYLEDFYdekkgDGSFRE---KYEEcvadERLSRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGMIYSS 454
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 419 NLCAEIVQYSDA----EET---------------AVCNLASIAVNSCVVVDearfdfeKLRHITKVVVRNLNKIIDRNRY 479
Cdd:PRK09209 455 NLCTEIMQNMSPtvmiQEIisggqivitkqpgdfVVCNLSSINLGRAVTAD-------VLERLIPIQVRMLDNVIDLNQL 527
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 480 PIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQGSPASEGil 559
Cdd:PRK09209 528 PVPQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKGAYPVFKGSDWQTG-- 605
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 560 QYdmWDVRPTSLWDWGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPftsnvylrrvlagefqvvnqyliddlI 639
Cdd:PRK09209 606 EY--FERRGYNSPQWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDP--------------------------I 657
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 640 KLKLYTSEMRNaifaHKGSIQAIDGIPDHIKRLYKTAWEMKCKRMIEMAADRNAFIDQSQSLNLFVAEPTYAL-MTSIHD 718
Cdd:PRK09209 658 YSAFYYEEKKD----YRRPVTAPDLSLDTWPYYEKGAYKVDQFWSIRQNAARQRHVDQSISFNFYVPSTIRASeLLDLHM 733
|
650
....*....|....*.
gi 90592870 719 YTWRSGLKTgMYYLRT 734
Cdd:PRK09209 734 TAWKEGLKT-TYYVRS 748
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
121-735 |
4.73e-112 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 360.22 E-value: 4.73e-112
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 121 GDEINEAIDHAVDYTYKFFGYKTLE---NGYLLKI-DNQVAERPQHMLMRVALGIHGDDIQDAIE----TYRMMSRKMFT 192
Cdd:PRK12364 218 REEIEEAAGFIDPERDKLFTYSGLDlllKRYVIRThSHEPLESPQEMFLGIALHLAMPEKQDRMGwvkrFYDMLSKLKVT 297
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 193 HASPTLFSAGTPMAQMCSCFLLGIrSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVF 272
Cdd:PRK12364 298 MATPTLSNARKPFHQLSSCFIDTV-PDSLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLA 376
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 273 NNMVRHVDQGGKRKGALAVYIEPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPDLF--MERVNANGVWSLMCPN---- 346
Cdd:PRK12364 377 NDTAVAVDQLGMRQGAVAVYLDVWHKDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFwkMVRDDINQSWYLFCPHeilt 456
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 347 -KCPGLSDCYGSAFEELYRKYEEEGRY-QQQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCSNLCAEI 424
Cdd:PRK12364 457 vKGYALEDYYGEEWEKRYLDCVNDARIsKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANPNKHKGMIYCSNLCTEI 536
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 425 VQYSDAEET-----------------------AVCNLASIAVNSCVVVDEarfdfEKLRHITKVVVRNLNKIIDRNRYPI 481
Cdd:PRK12364 537 AQNMSAIETvsteietedgdtvvvtttrpgdfVVCNLASLSLGNIDLEDE-----EELEEVVRTVVRALDNVIDLNFYPV 611
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 482 ESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQGSPASEGilQY 561
Cdd:PRK12364 612 PYAQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTG--AY 689
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 562 dmWDVRPTSLWDWGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPftsnvylrrvlagefqVVNQYLIDDlikl 641
Cdd:PRK12364 690 --FRKRGYTSEEWQRLAREVAENGMRNAYLLAVAPTSSTSIIAGTTAGVDP----------------VMKRYFLEE---- 747
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 642 klytsemrnaifaHKGSI--QAIDGIPDHIKRLYKTAWEMKCKRMIEMAADRNAFIDQSQSLNLFVA-EPTYALMTSIHD 718
Cdd:PRK12364 748 -------------KKGALmpRVAPELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITnEFTMRQVLDLYL 814
|
650
....*....|....*..
gi 90592870 719 YTWRSGLKTgMYYLRTK 735
Cdd:PRK12364 815 LAWEEGVKT-IYYVRSK 830
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
3-735 |
1.36e-111 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 357.50 E-value: 1.36e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 3 LHVIRRDGSRKEVHLHDIKAGIETLCFNLNKqyVNAAVVALNIMKGIRPGITTEELN-------VYAADV-VASMTYIhh 74
Cdd:PRK08447 2 ITVVKRNGRIEPLDISKIQKYTSDAVEGLEG--VSQSELEVDAKIQFRDGITTEEIQqtliktaVDKIDIdRPNWTFV-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 75 dfavlAGRILVDDLHNKIDAsfsevvFNLHRHklvSDELASVVESHG------------DEINEAIDHAVDYTYKFFGYK 142
Cdd:PRK08447 78 -----AARLFLYDLYHKVSG------FTGYNH---LKEYFEKGEKEGrillglkekydlDDLNAYIKPERDLQFNYLGIK 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 143 TLENGYLLKIDNQVA-ERPQHMLMRVA--LGIHGDDIQD-AIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLlGIRS 218
Cdd:PRK08447 144 TLYDRYLIKDRNNNPiELPQHMFMAIAmfLAQNELDPQKwAKKFYDVISKFEVMLATPTLSNARTTRHQLSSCYI-GSTP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 219 DSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHA 298
Cdd:PRK08447 223 DNIEGIFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAIAVDQLGTRKGAIAVYLEPWHM 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 299 DIYSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGSAFEELYRKYE-EEGRYQQQVR 377
Cdd:PRK08447 303 DISDFIDLRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELYGEEFEKRYLEYEkDEKIIKEYIN 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 378 AQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVQ-------------------YSDAEE------ 432
Cdd:PRK08447 383 AKELWKKILTNYFETGLPFLCFKDNANRANPNAHAGIIRSSNLCTEIFQntapnhykikiefedgsieFFEEEElvtvds 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 433 -------------------------------TAVCNLASI---AVNSCvvvdearfdfEKLRHITKVVVRNLNKIIDRNR 478
Cdd:PRK08447 463 gitkkakkitsldslkgkkiyivekekkdgkTAVCNLASInlsKINTK----------EDIERVVPIAIRMLDNVIDLNF 532
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 479 YPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQGSPASEGI 558
Cdd:PRK08447 533 YPNRKVKATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLALEKGVYPDFEGSNWSKGI 612
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 559 LQYDMWDVRPTSL----------WDWGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPFTSNVYLRRVLAGEFQ 628
Cdd:PRK08447 613 FPIDKANEEAKKLvergglfdsaCDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTIEPVYKRKWFEENLSGLIP 692
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 629 VVnqyliddLIKLKLYTSEmrnaifahkgsiqaidgipdhikrLYKTAWEMKCKRMIEMAADRNAFIDQSQSLNLFV--- 705
Cdd:PRK08447 693 VV-------VPNLSPETWQ------------------------YYTPAYDLDQKDLIKAAAVRQKWIDQGQSLNIFLsld 741
|
810 820 830
....*....|....*....|....*....|.
gi 90592870 706 -AEPTYalMTSIHDYTWRSGLKTgMYYLRTK 735
Cdd:PRK08447 742 kASGKY--LNEIYTLAWKLGLKS-TYYLRSE 769
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
128-778 |
5.52e-99 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 318.83 E-value: 5.52e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 128 IDHAVDYTYKFFGYKTLENGYLLKidnqvAERPQHMLMRVALGIHGDDIQDAIETYRMMSRKMFTHASPTLFSAGTPMAQ 207
Cdd:PRK09102 13 IDRSRDAWLTEFGKATLRDRYLLE-----GESYQDLFARIAEAYADIDPEHAQRFYDYMSRGWFMPATPVLSNGGTDRGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 208 MCSCFLLGIrSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINStNGVASGVEPMVRVFNNMVRHVDQGGKRKG 287
Cdd:PRK09102 88 PISCFLNYV-EDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPIRN-NGKSSGIIPFIKVMDSLTLAISQGSLRRG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 288 ALAVYIEPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPnkcpglsdcygsafeelyrkye 367
Cdd:PRK09102 166 SFAVYLDIEHPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISP---------------------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 368 EEGRYQQQVRAQDLHRFIVETQVETGGPYMLYKDACNRK--SNQQNLG-TIKCSNLCAEI-----VQYSDAEETAVCNLA 439
Cdd:PRK09102 224 KDKSVIRTVKARDLWAKILETRIETGEPYLLFIDNVNRAlpEVYKDLGlKVKASNLCSEItlptgIDHLGEDRTAVCCLS 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 440 SiavnscvvVDEARFD-FEKLRHITKVVVRNLNKI----IDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYES 514
Cdd:PRK09102 304 S--------LNLEYYDeWKDTDAFIEDLMRFLDNVlqdfIDKAPDEMERAKYSAMRERSVGLGVMGFHSYLQSKMIPFES 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 515 DEAMLLNRQIAETIYFGALEASCELAKTWGSyssfqgspasegilqydmwdvrptslwdwgtlKEDIKKHGL--RNSLLV 592
Cdd:PRK09102 376 VMAKQWNKKIFKHIREQADKASKELAKEKGE--------------------------------CPDAAGYGVmrRFSTKM 423
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 593 AYMPTATTAQILGN-NESFEPFTSNVYLRRVLAGEFQVVNQYLIDDLIKLKLYTSEMRNAIFAHKGSIQAIDGIPDHIKR 671
Cdd:PRK09102 424 AIAPTASISIILGNtSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLLEEKGKDTDEVWSSILTNEGSVQHLDFLSEEEKD 503
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 672 LYKTAWEMKCKRMIEMAADRNAFIDQSQSLNLFV---AEPTYALMtsIHDYTWRSGLKTgMYYLRTKPAahtQQFTVEQQ 748
Cdd:PRK09102 504 VFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFLpanVPKRDLNK--LHFEAWKKGVKS-LYYQRSKSV---QRADKVSH 577
|
650 660 670
....*....|....*....|....*....|
gi 90592870 749 FTVERGDVCKKRKINNYDEdaaqnvCASCE 778
Cdd:PRK09102 578 DVLKKRLVEKSAFNRDYDE------CLACQ 601
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
1-735 |
6.36e-98 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 320.60 E-value: 6.36e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 1 MQLHVIRRDGSRKEVHLHDIKAGIETLCFNLNKQyvNAAVVALNIMKGIRPGITTEEL-------------NVYAADVVA 67
Cdd:PRK07088 1 MNIKIKKRDGQYEPLQVEKTKKMVKLACEGLYGC--DPLELELDSRIQFRDGMTTKEIqksliqtaiekviQNSKDNNGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 68 SMTYIHHDFAVLAGRILVDDLHNKIDAS----------FSEVVFNLHRHKLVSDELasvVESHGD----EINEAIDHAVD 133
Cdd:PRK07088 79 NTKKTNPNWQYVAARLYVFDLYKEARINrhynsfgygdYYELVKKLVEEKLYGEYL---LQNYSKeeikELEKYIKPERD 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 134 YTYKFFGYKTLENGYLLKIDN-QVAERPQHMLMRVALGIHGDDIQD-----AIETYRMMSRKMFTHASPTLFSAGTPMAQ 207
Cdd:PRK07088 156 FLFNYEGLKLLADRYLVKGFNrEILELPQERFMGIAMHLAIPEGKEkrvyyAKKFYDLLSELKATVATPTLSNAGTPFYQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 208 MCSCFLLGIrSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKG 287
Cdd:PRK07088 236 LSSCFISVV-DDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAIAVDQLGKRKG 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 288 ALAVYIEPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCP---NKCPG--LSDCYGSA---- 358
Cdd:PRK07088 315 GAAITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPheiKKVKGysLEDYYDEEdrke 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 359 FEELYRKYEEEGRYQQQ-VRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVQYSDAEETA--- 434
Cdd:PRK07088 395 FTKKYLECEEDTNIPRRtVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKGMIYSSNLCHEIAQNMSESELLeee 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 435 --------------------VCNLASIAVnscvvvdeARFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPI 494
Cdd:PRK07088 475 iidengyyevvqkikagdmvTCNLNSIVL--------GNVDDEELEEVIPTQIRMLDNVISLNYYPVPEAEITSDKYRAI 546
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 495 GVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQGSPASEGilqyDMWDVRPTSLWDW 574
Cdd:PRK07088 547 GLGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETG----KYFERRGYNSERW 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 575 GTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPftsnvylrrvlagefqVVNQYLIDDliklklytsemrnaifa 654
Cdd:PRK07088 623 KKLKEEIKKYGMRNGYITAVAPTGSTSNIANTTAGIDP----------------VFKRFFMEE----------------- 669
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 655 HKGSI--QAIDGIPDHIKRLYKTAWEMKCKRMIEMAADRNAFIDQSQSLNLFVAePTYALMTSIHDYT--WRSGLKTgMY 730
Cdd:PRK07088 670 KKGSFtpKTAPDLNEENFWYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYIT-PEYKAKQILNLYIeaWKQGVKT-IY 747
|
....*
gi 90592870 731 YLRTK 735
Cdd:PRK07088 748 YVRNK 752
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
181-682 |
2.63e-89 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 288.75 E-value: 2.63e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 181 ETYRMMSRKMFTHASPTLFSAGTPM-AQMCSCFLLGIRSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTN 259
Cdd:cd02888 3 EFFYLLLSQGFIPNSPTLMNAGTGElGQLSACFVLPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 260 GVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIYSVLnlkrnmgaeDCKARDLMYALW--------VPDLFM 331
Cdd:cd02888 83 GVASGPVSFMRVFDAATGVIKQGGTRRGANMGVLDVDHPDIEEFI---------DAKMKEEKTVVLqnfnisvaVTDAFM 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 332 ERVNANGVWSLMCPNKCPGlsdcygsafEELYRKyeeegryqqqVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQN 411
Cdd:cd02888 154 EAVENDEPWELRNPREPDT---------GKVYRT----------VPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 412 LGTIKCSNLCAEIVQYSDAeetaVCNLASIAVNSCVVVDE--ARFDFEKLRHITKVVVRNLNKIIDRNRYPI-ESARMSN 488
Cdd:cd02888 215 LGRINATNPCGEQPLLPYE----SCNLGSINLSKFVKNPFggASFDFERLREAVRLAVRFLDNVIDVNRYPLpEIAEETK 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 489 MKhRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQGSpasegilQYDMWDVRP 568
Cdd:cd02888 291 AT-RRIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDAS-------RYLMLKVIV 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 569 TSLWDWGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPFTSNVYLRRVlagefQVVNQYLIDDLI-KlklyTSE 647
Cdd:cd02888 363 NAKELPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPIFSPEDHVRM-----QAALQPWVDGAIsK----TIN 433
|
490 500 510
....*....|....*....|....*....|....*
gi 90592870 648 MRNaifahkgsiqaiDGIPDHIKRLYKTAWEMKCK 682
Cdd:cd02888 434 LPN------------DATVEDVEAVYLLAWKLGLK 456
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
1-762 |
1.41e-85 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 287.39 E-value: 1.41e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 1 MQLHVIRRDGSRKEVHLHDIKAGIETLCFNLNkqyVNAAVVALNIMKGIRPGITTEE----LNVYAADvvaSMTYIHHDF 76
Cdd:PHA02572 2 MIINVIKSSGVSQPFDLEKIHKVLEWACEGTG---VDPSELEENSKIQLRDGMTTKDiqeiLIKSAAD---LISVEEPDY 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 77 AVLAGRILVDDLHNKIDASFSEVVFNLHRHKLVSDEL--ASVVESHGDE----INEAIDHAVDYTYKFFGYKTLENGYLL 150
Cdd:PHA02572 76 QYVAARLLMFALRKQVYGQFEPPSFIDHISKCVNEGKydPEILSKYSAEeityLESFIDHDRDFEFTYAGAMQLKEKYLV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 151 K--IDNQVAERPQHMLMRVALGIHGDDIQDA-----IETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIrSDSIDG 223
Cdd:PHA02572 156 QdrSTGEIYETPQFAYMLIAMALHQDEPKEDrlehvIRFYNAVSTRKISLPTPIMAGVRTPTRQFSSCVVIES-GDSLDS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 224 IYETlgdCAAISKY---GGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADI 300
Cdd:PHA02572 235 INKT---AMAIVKYiskRAGIGINAGMIRAEGSKIRGGEVRHTGVIPFWKHFQTAVKSCSQGGIRGGAATAYYPIWHLEV 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 301 YSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPG-LSDCYGS---AFEELYRKYEEEGRY-QQQ 375
Cdd:PHA02572 312 EDLLVLKNNKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGGeLYDAYFAdqdRFRELYEALEKDPSVrKKR 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 376 VRAQDLHRFIVETQVETGGPYMLYKDACNRKSNqqNLGTIKCSNLCAEIV-------QYSDAEETAVCNLASIavnscvV 448
Cdd:PHA02572 392 IKAQELFLLLLKERSETGRIYIMFIDHCNNHSP--FKDPIRQSNLCCEIAlptkplnHIDGEGEIALCTLSAI------V 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 449 VDEARfDFEKLRHITKVVVRNLNKIIDRNRYPIESArMSNMKHRPIGVGIQG----LADAFVllrmPYESDEAMLLNrQI 524
Cdd:PHA02572 464 LGNFE-DQDEIEELAEVAVRALDNLLDYQDYPVPAA-LKAKKRRSLGVGVTNyahyLAKNFA----SYEDANADLVH-EL 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 525 AETIYFGALEASCELAKTWGSYSSFQGSPASEGILQYDMWD------VRPTSLWDWGTLKEDIKKHGLRNSLLVAYMPTA 598
Cdd:PHA02572 537 FERLQYYLIKASNKLAKEKGACEYFSDTKYSRGELPIDWYKkkvdelVAPKYNCDWESLREDLKKYGIRNSTLSALMPCE 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 599 TTAQILGNNESFEPFTSNVYLRRVLAGEF-QVVNQYliddliklklytsemrnaifahkgsiqaidgipDHIKRLYKTAW 677
Cdd:PHA02572 617 SSSQVSNSTNGIEPPRGPVSIKKSKEGPFnQVVPNV---------------------------------ETLKDLYDLLW 663
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 678 EMK---CKRMIEMAADRNAFIDQSQSLNLFVAEPTY----ALMTSIHD---YTWRSGLKTgMYYLRTKPAAHTQQFTVEQ 747
Cdd:PHA02572 664 DLAkkgNKGYLTQVAIMQKFVDQAISANTSYDPENYpngkVPMSVMLDdllYFYYYGGKT-LYYHNTRDGKGTEDYEIET 742
|
810
....*....|....*
gi 90592870 748 QftveRGDVCKKRKI 762
Cdd:PHA02572 743 P----KAEDCDSCKL 753
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
144-726 |
4.32e-85 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 281.13 E-value: 4.32e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 144 LENGYLLKI-DNQVAERPQHMLMRVALGIHGDDIQDAIET--------YRMMSRKMFTHASPTLF-SAGTPMAQMCSCFL 213
Cdd:TIGR02504 2 LAARYLLKDeDGNIIESPEDLFRRVARALAAAEDKYNSPVwkqwyerfYDLMVNLGFIPNSPTLMnAGGTRLGQLSACFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 214 LGIRsDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASG-VEPMvRVFNNMVRHVDQGGKRKGALAVY 292
Cdd:TIGR02504 82 LPVE-DSMEDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGpVSFM-RVFDSAAGVVKQGGTRRGAQMGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 293 IEPWHADIYSVLNLKRNMGaedcKARDLMYALWVPDLFMERVNANGVWSLMCP-NKCPGlsdcygsafeelyrkyeeegr 371
Cdd:TIGR02504 160 LDVWHPDIEEFIEAKAKEG----KLQNFNISVGVTDEFMEAVENDEEYELRNPrTGEYK--------------------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 372 yqqQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCSNLCAEIVQYSDAeetaVCNLASIAVnSCVVVD- 450
Cdd:TIGR02504 215 ---EVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQPLLPYE----SCNLGSINL-AKFVKNd 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 451 ---EARFDFEKLRHITKVVVRNLNKIIDRNRYPI-ESARMSNMKhRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAE 526
Cdd:TIGR02504 287 fgdEASFDFERLREVVRLATRFLDNVIDINVFPLpEIAENTKKT-RRIGLGIMGLADLLIKLGIPYDSEEARELAEEVME 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 527 TIYFGALEASCELAKTWGSYSSFQGSPASEGILQYDMW-DVRPTSLWDWgtlkedIKKHGLRNSLLVAYMPTATTAQILG 605
Cdd:TIGR02504 366 FIADAAYRASAELAKERGAFPLYDASKYPMGRAMGARIpSALPAEIREA------IRKYGIRNAQLTTIAPTGTISLIAG 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 606 NNESFEPFTSNVYLRRVLAG-EFQVVNQYLIDDLIKLKLYTSEMRNAIfAHKGSIQAIDGiPDHIKRLYKTAWEMKCKRM 684
Cdd:TIGR02504 440 TSSGIEPVFALVYFRNVTVGgELLEVNPLVELALRELGYYSDEIVKYV-DEKGTVEGAPG-PEELPKVFVTAMDISPEDH 517
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 90592870 685 IEMAADRNAFIDQSQS--LNLfVAEPTYALMTSIHDYTWRSGLK 726
Cdd:TIGR02504 518 VLMQAAIQPWVDSSISktINM-PSDATVEDVKAVYLEAWKLGLK 560
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
144-676 |
8.67e-68 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 238.68 E-value: 8.67e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 144 LENGYLLKIDN-QVAERPQHMLMRVALGI--------HGDDIQD-AIETYRMMSRKMFTHASPTLFSAGTPMAQMCSCFL 213
Cdd:PRK08665 20 LEKRYLKKDEDgKPIETPEDMFRRVARTIaaaeliydSKADVEAlADRFYDLMTSLEFLPNSPTLMNAGRELGQLSACFV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 214 LGIrSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGA----L 289
Cdd:PRK08665 100 LPV-GDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGAnmgiL 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 290 AVYiepwHADIysvlnlkrnMGAEDCKARD-------LMYALwvPDLFMERVNANGVWSLMCPNkcpglsdcygsafeel 362
Cdd:PRK08665 179 RVD----HPDI---------MEFITCKEDNgeltnfnISVAI--TEAFMEAVEADEEYDLINPR---------------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 363 yrkyeeEGRYQQQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTIKCSNLCAE--IVQYSdaeetaVCNLAS 440
Cdd:PRK08665 228 ------TGEVVGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGEqpLLPYE------SCNLGS 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 441 IavNSCVVVDEARFDFEKLRHITKVVVRNLNKIIDRNRYPIEsaRMSNMKH--RPIGVGIQGLADAFVLLRMPYESDEAM 518
Cdd:PRK08665 296 I--NLSKMVKNGDVDWEKLREVVHLAVRFLDNVIDANKYPLP--QIEEMTKgnRKIGLGVMGWADMLIQLGIPYDSEEAV 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 519 LLNRQIAETIYFGALEASCELAKTWGSYSSFQGSpasegilqydMWDVRptslwdwGTLKedikkhgLRNSLLVAYMPTA 598
Cdd:PRK08665 372 ELAEKVMKFIQDEAHAASRELAEERGPFPNYEGS----------IYDKD-------GLGP-------MRNATVTTIAPTG 427
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 90592870 599 TTAQILGNNESFEPFTSNVYLRRVLAGEFQV-VNQYLIDDLIKLKLYTSEMRNAIfAHKGSIQAIDGIPDHIKRLYKTA 676
Cdd:PRK08665 428 TISIIAGCSSGIEPLFALSFTRNVMDGERLVeVNPVFEAAAKEEGFYSEELMEKI-AEKGSIQDIDEVPEDVRRVFVTA 505
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
173-703 |
1.46e-66 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 235.52 E-value: 1.46e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 173 GDDIQDAIET-YRMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIrSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSR 251
Cdd:PRK06406 213 WDSIEEYINKfEEVMSNLKFVPNSPTLMNAGTKLGQLSACFVLPV-PDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPK 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 252 GTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIYSVLNLKrnmGAEDCKARDLMYALWVPDLFM 331
Cdd:PRK06406 292 DDIVASTKGVASGPLSFMRIFDVTTDVIKQGGKRRGANMGILSYHHPDIMEFITSK---DSENKVLSNFNISVAVTDEFF 368
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 332 ERVNANGVWSLMCPnkcpglsdcygsafeelyrkyeEEGRYQQQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQN 411
Cdd:PRK06406 369 DKLDNDDYYPLRNP----------------------RNGKEVKRIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKN 426
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 412 LGTIKCSNLCAE--IVQYSDaeetavCNLASIavNSCVVVDEARFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNM 489
Cdd:PRK06406 427 LGEIESTNPCGEqpLLPYES------CNLGSI--NLSKFVENGKIDWDRLRETVHIATRFLDNVIDANKFPVPQIKEMTR 498
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 490 KHRPIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQGSpasegilqydmwdvrpt 569
Cdd:PRK06406 499 MTRKIGLGVMGFADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGVFPAWYGS----------------- 561
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 570 slwDWgtLKEDIKkhgLRNSLLVAYMPTATTAQILGNNESFEPFTSNVYLRRVLAG-EFQVVNQYLIDDLIKLKLYTSEM 648
Cdd:PRK06406 562 ---EW--EKKGIK---MRNSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRHVLNGqELLEVNPLFEEITRKRGLYSEEL 633
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*..
gi 90592870 649 RNAIfAHKGSIQAIDgIPDHIKRLYKTAWEMKCKRMIEMAADRNAFIDQ--SQSLNL 703
Cdd:PRK06406 634 MRKV-AETGNLQNID-VPEDIKRIFVTAHEIDPQWHVLMQATFQRYCDSgvSKTINL 688
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
2-612 |
9.18e-61 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 219.09 E-value: 9.18e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 2 QLHVIRRDGSRKEVHLHDIKAGIETLCFNLNKqyVNAAVVALNIMKGIRPGITTEELN----VYAADVVASMTyihHDFA 77
Cdd:PRK09103 1 SLLVTKRDGRTERINLDKIHRVITWAAEGLHN--VSVSQVELRSHIQFYDGIKTSDIHetiiKAAADLISRDA---PDYQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 78 VLAGRILVDDLHNKIDASFSEVVFNLHRHKLVS----DE--LASVVESHGDEINEAIDHAVDYTYKFFGYKTLENGYLL- 150
Cdd:PRK09103 76 YLAARLAIFHLRKKAYGQFEPPALYDHVVKMVEmgkyDKhlLEDYTEEEFDQMDTFIDHWRDMNFSYAAVKQLEGKYLVq 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 151 -KIDNQVAERPQHMLMRVAL--------GIHGDDIQ---DAIETYRMmsrkmfthASPTLFSAG--TPMAQMCSCFLLGI 216
Cdd:PRK09103 156 nRVTGEIYESAQFLYILVAAclfsnypkETRLDYVKrfyDAVSTFKI--------SLPTPIMSGvrTPTRQFSSCVLIEC 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 217 rSDSIDGIYETlgdCAAISKY---GGGLGVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYI 293
Cdd:PRK09103 228 -GDSLDSINAT---SSAIVKYvsqRAGIGINAGRIRALGSPIRGGEAFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFY 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 294 EPWHADIYSVLNLKRNMGAEDCKARDLMYALWVPDLFMERVNANGVWSLMCPNKCPGLSDCYGS---AFEELYRKYEEEG 370
Cdd:PRK09103 304 PIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDVPGLYDAFFAdqdEFERLYTKYEQDD 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 371 RY-QQQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSN-QQNLGTIKCSNLCAEIV-------QYSDAE-ETAVCNLAS 440
Cdd:PRK09103 384 SIrKKRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPKVAPVRQSNLCLEIAlptkplnDVNDENgEIALCTLSA 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 441 I---AVNScvvVDEarfdFEKLrhiTKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLADAFVLLRMPYESDEA 517
Cdd:PRK09103 464 FnlgAINS---LDE----LEEL---ADLAVRALDALLDYQDYPIPAAKRGAMGRRTLGIGVINFAYYLAKNGVRYSDGSA 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 518 MLLNRQIAETIYFGALEASCELAKTWGSYSSFQGSPASEGILQYDMW-----DVRPTSL-WDWGTLKEDIKKHGLRNSLL 591
Cdd:PRK09103 534 NNLTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAQGILPIDTYkkdldAICNEPLhYDWETLREEIKTHGLRNSTL 613
|
650 660
....*....|....*....|.
gi 90592870 592 VAYMPTATTAQILGNNESFEP 612
Cdd:PRK09103 614 SALMPSETSSQISNATNGIEP 634
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
108-647 |
1.34e-35 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 144.99 E-value: 1.34e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 108 LVSDELASVVESHGDEINEAIDHAVDYTYKffgykTLENGYllkidNQVAERPQHMLMRVAlgIHGDDIQDAIET-YRMM 186
Cdd:PRK08115 96 LVEEEFRGVLDDPEEAETGIVTRSLDTIEK-----PLEIFY-----EQIAKRNATGLAAVE--KTEEKRKESFEKfYQEL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 187 SRKMFTHASPTLFSAGTPM-AQMCSCFLLGIRSDSIDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGV 265
Cdd:PRK08115 164 VNMNFVPAGRVLYGAGSKTdVTYFNCYVMPFVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNGKSSGS 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 266 EPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIY-------------------------------------------- 301
Cdd:PRK08115 244 VSWLDDIAKLTHLVEQGGSRRGAQMIMLADWHPDILefiiskmqnprilryllentedeqikrlvkeklkftplseveea 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 302 ---SVLNLKRNMG-----------AEDCKARDLMYALWVPDL-------------FMERVNANGVWSLMCP---NKCPGL 351
Cdd:PRK08115 324 myqAIVNYKNIEGqggfdtkvikeAENKLRTGGTYTVNNPEFltganisvcltkeFMEAVENDEEYELRFPdveNYTEEE 403
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 352 SDCYGSAFEEL--YRKYEEEG---RYQQQVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLG-TIKCSNLCAE-- 423
Cdd:PRK08115 404 MEIYNEEWHEVgdVREWEKMGypvRTYRKIKAKELWNLINICATYSAEPGIFFIDNANEMTNAKAYGqKVVATNPCGEqp 483
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 424 IVQYSdaeetaVCNLASIAVNSCVVVDEARFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPIGVGIQGLAD 503
Cdd:PRK08115 484 LAPYS------VCNLAAINLANMADKETKTVDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRVGLGVMGLHD 557
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 504 AFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQGSPASE------GILQYDMWDVRPTSlwdwgtL 577
Cdd:PRK08115 558 LLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPFLVGQTEEEtaklreAFINTGYMKKMPED------I 631
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 578 KEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPFTSNVYLRRVLAGEFQVVNQYLIDDLIKLKLYTSE 647
Cdd:PRK08115 632 REDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPYFSFSYYRSGRLGKFIEVKADIVQEYLDKHPEADE 701
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
418-679 |
9.55e-35 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 143.37 E-value: 9.55e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 418 SNLCAEIVQYsdaeETAVCNLASIAVNSCVVVDE---ARFDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRPI 494
Cdd:PRK08332 1294 SHNCGEEPLY----EYESCNLASINLAKFVKYDEngkPYFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTRRI 1369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 495 GVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQ------GSPASEGILQYDMWDVrp 568
Cdd:PRK08332 1370 GVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEkteypkGELPVEGFYHPEIWNL-- 1447
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 569 tslwDWGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNESFEPFTSNVYLRRVLAGEFQVVNQYLIDDLIKLKLYTSEM 648
Cdd:PRK08332 1448 ----PWDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLYSEEL 1523
|
250 260 270
....*....|....*....|....*....|.
gi 90592870 649 RNAIFAHKGSIQAIDGIPDHIKRLYKTAWEM 679
Cdd:PRK08332 1524 LKKISDNYGSVQGLEEIPEDMQRVFVTALDI 1554
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
194-737 |
3.45e-30 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 126.45 E-value: 3.45e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 194 ASPTLFSAGT-PMAQMCSCFLLGIRSDS-----IDGIYETLGDCAAISKYGGGLGVNVHCVRSRGTRINSTNGVASGVEP 267
Cdd:PRK06948 70 AGRIMANAGAaPDQTMVNCFVHPIRAPAaltavHPNLDRALDDARLTLLMGGGIGYDFSAIPPADARPDADHPDSPGVCA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 268 MVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIYSVLNLKRNmgaedcKAR--DLMYALWVPDLFMERVNANGVWSLM-- 343
Cdd:PRK06948 150 ALDRFDRICAALPFRDGRRGAQMAVLRCDHPDLLAFVAAKRG------RARwtTFNLSVAVTDAFMQAVAQDLPWALRhr 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 344 -CPNKCPG----LSD---CYGSafeelyrkyeeegryqqqVRAQDLHRFIVETQVETGGPYMLYKDACNRKSNQQNLGTI 415
Cdd:PRK06948 224 aPPRRAAGgalrGADgawTYAT------------------VPARHLWREIVSAARDSAEPGLLFVDTIDAANPLREHERI 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 416 KCSNLCAE--IVQYSDaeetavCNLASIAVNSCV-----VVDEARFDFEKLRHITKVVVRNLNKIIDRNRYPI-ESARMS 487
Cdd:PRK06948 286 DATNPCGEqpLPPYGS------CVLGPIDLSRFVrhpfgVGGEPRFDFAALATAVRIQVRMLDNALDLTRWPLaAHAREA 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 488 NMKHRpIGVGIQGLADAFVLLRMPYESDEAMLLNRQIAETIYFGALEASCELAKTWGSYSSFQ-----GSPASEGILQyd 562
Cdd:PRK06948 360 RQKRR-IGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALAAERGAYPLCDpaahlDALRAGPPLP-- 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 563 mwdvrptslwdwGTLKEDIKKHGLRNSLLVAYMPTATTAQILGNNES--FEPFTSNVYLRRVLAGEFQVvnqyliddlik 640
Cdd:PRK06948 437 ------------HAVCHAIARHGLRNSHLLSFAPVGSVSLAFGDNCSpgIEPARAWIEHRPVRAGAGGA----------- 493
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 641 lKLYTSEMRnaifAHKgSIQAIDG----IPDHikrlYKTAWEMKCKRMIEMAADRNAFIDQSQSLNLFVAEP-TYALMTS 715
Cdd:PRK06948 494 -RGMRAENH----AYR-LFRSLRGeraaLPDY----FVTAADVAPADHLAMRAALQPYVDAGISKTVTLPNHySLAEVDA 563
|
570 580
....*....|....*....|..
gi 90592870 716 IHDYTWRSGLKtGMYYLRTKPA 737
Cdd:PRK06948 564 LLFQAWRAGLK-GITIFRPDPA 584
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
185-726 |
1.62e-27 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 119.69 E-value: 1.62e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 185 MMSRKMFTHASPTLFSAGTPMAQMCS-CFLLGIrSDSIDGI---YETLGdcaAISKYGGGLGVNVHCVRSRGTRInSTNG 260
Cdd:PRK06556 125 LLLHQKFSFNSPVWFNVGTESPQQVSaCFILSV-DDSMESIlnwYKEEG---MLFKGGSGTGTNLSRIRSSKELL-SGGG 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 261 VASGVEPMVRVFNNMVRHVDQGGK-RKGALAVYIEPWHADIYSVLNLKrnmGAEDCKARDLMYA---------------- 323
Cdd:PRK06556 200 TASGPVSFMRGADASAGTIKSGGAtRRAAKMVILDVDHPDIEEFIETK---AKEEDKIRALRDAgydmdlggeayssvqy 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 324 ------LWVPDLFMERVNANGVWSLMcpnkcpGLSDcyGSAFEElyrkyeeegryqqqVRAQDLHRFIVETQVETGGPYM 397
Cdd:PRK06556 277 qnannsVRVSDEFMRAVENDGEFGLR------ARTD--GEVIET--------------VDAKELFRKIAEAAWECADPGI 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 398 LYKDACNRKSNQQNLGTIKCSNLCAEivqYSDAEETAvCNLASIAVNScVVVDEARFDFEKLRHITKVVVRNLNKIIDRN 477
Cdd:PRK06556 335 QYDDTINDWHTCPESGRINASNPCSE---YMFLDNSS-CNLASLNLMK-FLRDDGTFDVESFRHAVELVITAMEISICFA 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 478 RYPIES-ARMSNMkHRPIGVGIQGLADAFVLLRMPYESDEAmllnRQIAetiyfGALEA---------SCELAKTWGSYS 547
Cdd:PRK06556 410 DFPTEKiARNTRA-FRQLGLGYANLGALLMATGLPYDSDGG----RALA-----AAITSlmtgeayrrSAELAGVVGPFE 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 548 SF------------QGSPASEGILQYDMWDvrpTSLWD-----WGTLKEDIKKHGLRNSLLVAYMPTAT--------TAQ 602
Cdd:PRK06556 480 GYarnaephlrvmrKHAAANDAIRPLGEVD---AALLEaakeaWDDALELGEKNGYRNAQASVLAPTGTigfmmdcdTTG 556
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 603 IlgnnesfEPFTSNV-YLRRVLAGEFQVVNQYLIDDLIKLKlYTSEMRNAIFAHKGSIQAIDGIPdHIKR----LYKTAw 677
Cdd:PRK06556 557 I-------EPDFALVkYKKLVGGGSMKIVNQTVPRALKKLG-YSEEQIEAIVEYIAEHGHIEGAP-GLKPehyaVFDCA- 626
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90592870 678 eMKC---KRMIE------MAADRNAFIDQ--SQSLNLfvaePTYALMTSIHD-YT--WRSGLK 726
Cdd:PRK06556 627 -MKPasgERSISpmghvrMMAAVQPFLSGaiSKTVNM----PEDATVEDIEEvYLegWKLGLK 684
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
138-204 |
8.21e-21 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 86.91 E-value: 8.21e-21
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90592870 138 FFGYKTLENGYLLKI-DNQVAERPQHMLMRVALGIHG-----DDIQDAIETYRMMSRKMFTHASPTLFSAGTP 204
Cdd:pfam00317 3 YLGAKVLEDRYLLKDeDGELLETPQDMFMRVALALAGaeleeDRLELAEEFYDLLSSLKFLPATPTLMNAGTP 75
|
|
| ATP-cone |
pfam03477 |
ATP cone domain; |
3-91 |
2.64e-11 |
|
ATP cone domain;
Pssm-ID: 397513 [Multi-domain] Cd Length: 86 Bit Score: 60.36 E-value: 2.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 3 LHVIRRDGSRKEVHLHDIKAGIETLCFNLNKQ-YVNAAVVALNIMKGIRPGITTEELnvyaADVVASMTYIHHDFAVLAG 81
Cdd:pfam03477 1 MKVIKRDGRREPFDKEKIRRAIEKACEKSPDQaDELASEVEEELEKSLEDGISTEEI----QDLVEKTLAEHPDYAVARA 76
|
90
....*....|
gi 90592870 82 RILVDDLHNK 91
Cdd:pfam03477 77 YILYRNLRKE 86
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
198-558 |
4.93e-09 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 59.08 E-value: 4.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 198 LFSAGTPMAQMCSCFLLGIR---SDSIDGIYETLGDC-----------AAISKYGGGLGVNVHCVRSRGT-----RINST 258
Cdd:cd00576 12 VITVGRPDLPFTGCVLVDYGdslDPGIKGVNETAKSIneaiqktyqiiALAASNQNGGGVSFARASSILSpygsrDYAKG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 259 NGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHA-----DIYSVLNLKRNMGAEdckardlMYALWVPDLFMer 333
Cdd:cd00576 92 SGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIGGVHKgkgdkISQEFLNLALANGGE-------GIPLNFPNLSV-- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 334 vnanGVWSLMcpnkcpglsdcygsafeelyrkyeeegrYQQQVRAQDLHRFIVETQVETGGPYMLYKDACNrksnqqnLG 413
Cdd:cd00576 163 ----RVSSDK----------------------------PGILVKAVELKQLIAEEARKTGSPGIFNDELCN-------LV 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 414 TIkcsnlcaeivqysdaeetavcNLASIAVNSCVVVDEArfDFEKLRHITKVVVRNLNKIIDRNRYPIESARMSNMKHRP 493
Cdd:cd00576 204 SL---------------------NLARIMEKAINGSMDV--VLEELEELAFLAVRALDCVIDSHDERIPTIELGGDERRT 260
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90592870 494 IGVGIQGLADAFVLLRMPY-ESDEAMLLNRQIAETIYFGALEASCEL--AKTWGSY---SSFQGSPASEGI 558
Cdd:cd00576 261 VGLGIAGVADLLIKLGLEKvGDPEADDLAAELVDQLKKHLVKATNERgfNFLLGLSpseSNSSGAPATNGV 331
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
174-240 |
1.12e-05 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 49.38 E-value: 1.12e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 90592870 174 DDIQDAIETY-RMMSRKMFTHASPTLFSAGTPMAQMCSCFLLGIRsDSIDGIYETLGDCAAISKYGGG 240
Cdd:PRK08332 235 DKYEKEIEEYfRLMTNQIFMPNTPALINSGRPLGMLSACFVVPIE-DDMESIMKAAHDVAMIQKAGGG 301
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
242-345 |
2.78e-04 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 44.76 E-value: 2.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90592870 242 GVNVHCVRSRGTRINSTNGVASGVEPMVRVFNNMVRHVDQGGKRKGALAVYIEPWHADIYSVLNLK-RNMGAEDCKARDL 320
Cdd:PRK08332 757 GLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGILEIWHPDIEKFIHAKeKNIGTNVLSNFNI 836
|
90 100
....*....|....*....|....*
gi 90592870 321 MYALWvpDLFMERVNANGVWSLMCP 345
Cdd:PRK08332 837 SVGIW--EDFWEALKEGKKYPLINP 859
|
|
| |
