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Conserved domains on  [gi|109392285|ref|YP_655095|]
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HNH endonuclease [Mycobacterium phage Llij]

Protein Classification

HNH endonuclease( domain architecture ID 10003646)

HNH endonuclease contains an HNH endonuclease signature motif and may catalyze the hydrolysis of DNA

Gene Ontology:  GO:0004519|GO:0003676|GO:0008270
PubMed:  28211904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
47-99 1.33e-05

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


:

Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 39.97  E-value: 1.33e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 109392285  47 KAVRERD-GCCMIQLPGCTGGADTADHVHPVAFGGdELSLANGQAACWHCHNRK 99
Cdd:COG1403   12 RAVLKRDnGRCQYCGRPFSGDALEVDHIIPRSRGG-TDTWENLVLLCRRCNRRK 64
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
47-99 1.33e-05

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 39.97  E-value: 1.33e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 109392285  47 KAVRERD-GCCMIQLPGCTGGADTADHVHPVAFGGdELSLANGQAACWHCHNRK 99
Cdd:COG1403   12 RAVLKRDnGRCQYCGRPFSGDALEVDHIIPRSRGG-TDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 47-100 9.67e-05

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.45  E-value: 9.67e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 109392285  47 KAVRERDGCCMIqlPGCTGGAD--TADHVHPVAFGGDeLSLANGQAACWHCHNRKS 100
Cdd:cd00085    5 LVLLARDGLCPY--CGKPGGTEglEVDHIIPLSDGGN-NDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 67-102 5.54e-04

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 35.02  E-value: 5.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 109392285   67 ADTADHVHPVAFGGdELSLANGQAACWHCHNRKSSR 102
Cdd:pfam01844  13 ALTVDHIIPLSDGG-ADDIENLILLCPSCHNKKHNR 47
 
Name Accession Description Interval E-value
McrA COG1403
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
47-99 1.33e-05

5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];


Pssm-ID: 441013 [Multi-domain]  Cd Length: 64  Bit Score: 39.97  E-value: 1.33e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 109392285  47 KAVRERD-GCCMIQLPGCTGGADTADHVHPVAFGGdELSLANGQAACWHCHNRK 99
Cdd:COG1403   12 RAVLKRDnGRCQYCGRPFSGDALEVDHIIPRSRGG-TDTWENLVLLCRRCNRRK 64
HNHc cd00085
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ...
 47-100 9.67e-05

HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.


Pssm-ID: 238038 [Multi-domain]  Cd Length: 57  Bit Score: 37.45  E-value: 9.67e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 109392285  47 KAVRERDGCCMIqlPGCTGGAD--TADHVHPVAFGGDeLSLANGQAACWHCHNRKS 100
Cdd:cd00085    5 LVLLARDGLCPY--CGKPGGTEglEVDHIIPLSDGGN-NDLDNLVLLCRKCHRKKH 57
HNH pfam01844
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ...
 67-102 5.54e-04

HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.


Pssm-ID: 396422 [Multi-domain]  Cd Length: 47  Bit Score: 35.02  E-value: 5.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 109392285   67 ADTADHVHPVAFGGdELSLANGQAACWHCHNRKSSR 102
Cdd:pfam01844  13 ALTVDHIIPLSDGG-ADDIENLILLCPSCHNKKHNR 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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