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Conserved domains on  [gi|53759122|ref|NP_000029|]
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adenomatous polyposis coli protein isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 732-1019 1.19e-166

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435476  Cd Length: 293  Bit Score: 515.29  E-value: 1.19e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    732 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDN-- 809
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    810 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKR-GLQISTTAAQ 886
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    887 IAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNS 966
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 53759122    967 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1019
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2223-2568 4.77e-110

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


:

Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 354.95  E-value: 4.77e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2223 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQIGGSSKAPSR 2301
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2302 SGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLTKQ 2381
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2382 TGLSKNASSI------PRSESASKGLNqmnngNGANKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKEAPSPTLRRK 2455
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2456 LEESASfESLSPSSRPASPTRSQaqtpvlsPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSES 2535
Cdd:pfam05956  226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297

                          330       340       350
                   ....*....|....*....|....*....|...
gi 53759122   2536 PSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2568
Cdd:pfam05956  298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2670-2843 5.04e-90

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


:

Pssm-ID: 399141  Cd Length: 174  Bit Score: 290.36  E-value: 5.04e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2670 RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVS 2749
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2750 ETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQ 2829
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 53759122   2830 SPKRHSGSYLVTSV 2843
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1036-1135 9.49e-57

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406923  Cd Length: 100  Bit Score: 192.04  E-value: 9.49e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   1036 LNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRV 1115
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 53759122   1116 GSNHGINQNVSQSLCQEDDY 1135
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1746-1839 5.89e-47

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435479  Cd Length: 94  Bit Score: 163.86  E-value: 5.89e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   1746 IMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFND 1825
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 53759122   1826 KLPNNEDRVRGSFA 1839
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 393-466 5.39e-45

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


:

Pssm-ID: 465870  Cd Length: 74  Bit Score: 157.32  E-value: 5.39e-45
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 53759122    393 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 466
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1283-1368 1.35e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435478  Cd Length: 89  Bit Score: 131.15  E-value: 1.35e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   1283 AEDEI-GCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLS-SESARHKAVEFSSGAKS 1360
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 53759122   1361 PSKSGAQT 1368
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1873-1947 2.75e-31

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 435480  Cd Length: 81  Bit Score: 118.81  E-value: 2.75e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 53759122   1873 DLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAAT 1947
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1662-1715 1.15e-24

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


:

Pssm-ID: 406927  Cd Length: 54  Bit Score: 98.71  E-value: 1.15e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 53759122   1662 IESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDD 1715
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 127-207 4.83e-22

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


:

Pssm-ID: 463275  Cd Length: 82  Bit Score: 92.32  E-value: 4.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    127 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRVAMEEQLG 205
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 53759122    206 TC 207
Cdd:pfam11414   81 LI 82
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 6.55e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


:

Pssm-ID: 435517  Cd Length: 52  Bit Score: 90.82  E-value: 6.55e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 53759122      4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1637-1660 1.46e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 49.30  E-value: 1.46e-07
                           10        20
                   ....*....|....*....|....
gi 53759122   1637 DMPRVYCVEGTPINFSTATSLSDL 1660
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 4.98e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 4.98e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 53759122     649 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 689
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2033-2052 3.90e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.58  E-value: 3.90e-05
                           10        20
                   ....*....|....*....|
gi 53759122   2033 DSEDDLLQECISSAMPKKKK 2052
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 8-272 3.60e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 3.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122      8 QLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDeamassgqidLLERLKELNLDSSNFPGVKL 87
Cdd:TIGR02168  744 QLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ----------LKEELKALREALDELRAELT 813

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122     88 RSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRES-TGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLT 166
Cdd:TIGR02168  814 LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlAAEIEELEELIEELESELEALLNERASLEEALALLR 893

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    167 KRIDSLpltenfslqtDMTRRQLEYEARQIRVAMEEqlgtCQDMEKRAQRRIARIQQIEKDIL-RIRQLLQSQATEAERs 245
Cdd:TIGR02168  894 SELEEL----------SEELRELESKRSELRRELEE----LREKLAQLELRLEGLEVRIDNLQeRLSEEYSLTLEEAEA- 958

                          250       260       270
                   ....*....|....*....|....*....|..
gi 53759122    246 SQNKHETGSHDAERQ-----NEGQGVGEINMA 272
Cdd:TIGR02168  959 LENKIEDDEEEARRRlkrleNKIKELGPVNLA 990
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-553 5.57e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.57e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 53759122     512 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 553
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-731 7.00e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 7.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 53759122    691 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 731
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1716-1737 1.46e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


:

Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.96  E-value: 1.46e-03
                           10        20
                   ....*....|....*....|..
gi 53759122   1716 NKAEEGDILAECINSAMPKGKS 1737
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 1291-1701 3.27e-03

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1291 QTTQEAD---SANTLQIAEIKEKIGTRSAEDPvsEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ 1367
Cdd:PTZ00449  480 QFTQEIKkliKKSKKKLAPIEEEDSDKHDEPP--EGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEV 557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1368 TPKSPP--EHYVQETPLMFSRCT----SVSSLDSFESRSIASSVQ-SEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP 1440
Cdd:PTZ00449  558 GKKPGPakEHKPSKIPTLSKKPEfpkdPKHPKDPEEPKKPKRPRSaQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1441 PPPQTAQTKR-EVPK----NKAPTAEKRESGPK------QAAVNAAVQRVQvlpdadtllhfaTESTPDGFSCSSSLSAL 1509
Cdd:PTZ00449  638 PPQRPSSPERpEGPKiiksPKPPKSPKPPFDPKfkekfyDDYLDAAAKSKE------------TKTTVVLDESFESILKE 705

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1510 SLDEPFIQKDVELRIMPPVQENDNG------NETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAM 1583
Cdd:PTZ00449  706 TLPETPGTPFTTPRPLPPKLPRDEEfpfepiGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAE 785

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1584 PTKSSRKAKKPAQTASKLPPPVARKPSqlpvyklLPSQNRLQPQKHVSFTPGDDMPRVYCVE--GTPINFSTATSLSDL- 1660
Cdd:PTZ00449  786 TGEPDEAMKRPDSPSEHEDKPPGDHPS-------LPKKRHRLDGLALSTTDLESDAGRIAKDasGKIVKLKRSKSFDDLt 858

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 53759122  1661 TIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQ 1701
Cdd:PTZ00449  859 TVEEAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVR 899
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1257-1274 6.63e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


:

Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.20  E-value: 6.63e-03
                           10
                   ....*....|....*...
gi 53759122   1257 ETIQTYCVEDTPICFSRC 1274
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 340-392 8.68e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 8.68e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 53759122     340 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 392
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 732-1019 1.19e-166

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 515.29  E-value: 1.19e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    732 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDN-- 809
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    810 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKR-GLQISTTAAQ 886
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    887 IAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNS 966
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 53759122    967 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1019
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2223-2568 4.77e-110

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 354.95  E-value: 4.77e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2223 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQIGGSSKAPSR 2301
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2302 SGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLTKQ 2381
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2382 TGLSKNASSI------PRSESASKGLNqmnngNGANKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKEAPSPTLRRK 2455
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2456 LEESASfESLSPSSRPASPTRSQaqtpvlsPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSES 2535
Cdd:pfam05956  226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297

                          330       340       350
                   ....*....|....*....|....*....|...
gi 53759122   2536 PSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2568
Cdd:pfam05956  298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2670-2843 5.04e-90

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 290.36  E-value: 5.04e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2670 RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVS 2749
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2750 ETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQ 2829
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 53759122   2830 SPKRHSGSYLVTSV 2843
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1036-1135 9.49e-57

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 192.04  E-value: 9.49e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   1036 LNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRV 1115
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 53759122   1116 GSNHGINQNVSQSLCQEDDY 1135
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1746-1839 5.89e-47

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 163.86  E-value: 5.89e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   1746 IMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFND 1825
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 53759122   1826 KLPNNEDRVRGSFA 1839
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 393-466 5.39e-45

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 157.32  E-value: 5.39e-45
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 53759122    393 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 466
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1283-1368 1.35e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 131.15  E-value: 1.35e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   1283 AEDEI-GCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLS-SESARHKAVEFSSGAKS 1360
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 53759122   1361 PSKSGAQT 1368
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1873-1947 2.75e-31

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 118.81  E-value: 2.75e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 53759122   1873 DLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAAT 1947
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1662-1715 1.15e-24

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 98.71  E-value: 1.15e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 53759122   1662 IESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDD 1715
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 127-207 4.83e-22

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 92.32  E-value: 4.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    127 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRVAMEEQLG 205
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 53759122    206 TC 207
Cdd:pfam11414   81 LI 82
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 6.55e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 90.82  E-value: 6.55e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 53759122      4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1637-1660 1.46e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 49.30  E-value: 1.46e-07
                           10        20
                   ....*....|....*....|....
gi 53759122   1637 DMPRVYCVEGTPINFSTATSLSDL 1660
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 4.98e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 4.98e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 53759122     649 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 689
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 6.26e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 6.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 53759122    649 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 689
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2251-2564 9.57e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 9.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2251 PPLKTPASKsPSEGQTATTSPRGAKPSVKSE----LSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGR 2326
Cdd:PHA03247 2703 PPPPTPEPA-PHALVSATPLPPGPAAARQASpalpAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2327 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGrqmsqqnltkqTGLSKNASSIPRSESASKGLNQ--M 2404
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA-----------GPLPPPTSAQPTAPPPPPGPPPpsL 2850

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2405 NNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRqstfikeAPSPTLRRKLEESA-SFESLSPSSRPASPTRSQAQTPV 2483
Cdd:PHA03247 2851 PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR-------LARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQP 2923

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2484 LSPSLPDMSLSTHSSVQAggwrKLPPNLSPTieyNDGRPAKRHDIARSHSESPSRLPINRSGTWK----RE------HSK 2553
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQP----PLAPTTDPA---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPL 2996

                         330
                  ....*....|.
gi 53759122  2554 HSSSLPRVSTW 2564
Cdd:PHA03247 2997 TGHSLSRVSSW 3007
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2033-2052 3.90e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.58  E-value: 3.90e-05
                           10        20
                   ....*....|....*....|
gi 53759122   2033 DSEDDLLQECISSAMPKKKK 2052
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
134-266 2.49e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 46.68  E-value: 2.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  134 LEELEKERSLLLADLDKEEKEKDWY--YAQLQNLTKRIDSLP---------LTENFSLQTDM---------TRRQLEYEA 193
Cdd:COG4717  104 LEELEAELEELREELEKLEKLLQLLplYQELEALEAELAELPerleeleerLEELRELEEELeeleaelaeLQEELEELL 183

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53759122  194 RQIRVAMEEQLgtcQDMEKRAQRRIARIQQIEKDILRIRQLLQsQATEAERSSQNKHETGsHDAERQNEGQGV 266
Cdd:COG4717  184 EQLSLATEEEL---QDLAEELEELQQRLAELEEELEEAQEELE-ELEEELEQLENELEAA-ALEERLKEARLL 251
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 8-272 3.60e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 3.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122      8 QLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDeamassgqidLLERLKELNLDSSNFPGVKL 87
Cdd:TIGR02168  744 QLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ----------LKEELKALREALDELRAELT 813

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122     88 RSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRES-TGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLT 166
Cdd:TIGR02168  814 LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlAAEIEELEELIEELESELEALLNERASLEEALALLR 893

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    167 KRIDSLpltenfslqtDMTRRQLEYEARQIRVAMEEqlgtCQDMEKRAQRRIARIQQIEKDIL-RIRQLLQSQATEAERs 245
Cdd:TIGR02168  894 SELEEL----------SEELRELESKRSELRRELEE----LREKLAQLELRLEGLEVRIDNLQeRLSEEYSLTLEEAEA- 958

                          250       260       270
                   ....*....|....*....|....*....|..
gi 53759122    246 SQNKHETGSHDAERQ-----NEGQGVGEINMA 272
Cdd:TIGR02168  959 LENKIEDDEEEARRRlkrleNKIKELGPVNLA 990
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-553 5.57e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.57e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 53759122     512 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 553
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-552 6.04e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 53759122    512 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 552
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-731 7.00e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 7.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 53759122    691 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 731
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1716-1737 1.46e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.96  E-value: 1.46e-03
                           10        20
                   ....*....|....*....|..
gi 53759122   1716 NKAEEGDILAECINSAMPKGKS 1737
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 11-247 1.61e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   11 KQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI---EDEAMASSGQIDLLE-RLKELNLDSSnfpgvK 86
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIaalARRIRALEQELAALEaELAELEKEIA-----E 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   87 LRSKM-SLRSYGSREGSVSSRSGECSPvPMGSFPRRGFVNGSRESTgYLEELEKERSLLLADLDKEEKEKDWYYAQLQNL 165
Cdd:COG4942   95 LRAELeAQKEELAELLRALYRLGRQPP-LALLLSPEDFLDAVRRLQ-YLKYLAPARREQAEELRADLAELAALRAELEAE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  166 TKRIDSLpltenfslqtdmtRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERS 245
Cdd:COG4942  173 RAELEAL-------------LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239


                 ..
gi 53759122  246 SQ 247
Cdd:COG4942  240 AE 241
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 134-259 2.20e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.90  E-value: 2.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    134 LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSL------------PLTENFSLQTDMTRRQLEYEARQIRVAME 201
Cdd:TIGR02169  232 KEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIeqlleelnkkikDLGEEEQLRVKEKIGELEAEIASLERSIA 311

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 53759122    202 EqlgtCQDMEKRAQRRIARIQ-QIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAER 259
Cdd:TIGR02169  312 E----KERELEDAEERLAKLEaEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEEL 366
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1291-1701 3.27e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1291 QTTQEAD---SANTLQIAEIKEKIGTRSAEDPvsEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ 1367
Cdd:PTZ00449  480 QFTQEIKkliKKSKKKLAPIEEEDSDKHDEPP--EGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEV 557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1368 TPKSPP--EHYVQETPLMFSRCT----SVSSLDSFESRSIASSVQ-SEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP 1440
Cdd:PTZ00449  558 GKKPGPakEHKPSKIPTLSKKPEfpkdPKHPKDPEEPKKPKRPRSaQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1441 PPPQTAQTKR-EVPK----NKAPTAEKRESGPK------QAAVNAAVQRVQvlpdadtllhfaTESTPDGFSCSSSLSAL 1509
Cdd:PTZ00449  638 PPQRPSSPERpEGPKiiksPKPPKSPKPPFDPKfkekfyDDYLDAAAKSKE------------TKTTVVLDESFESILKE 705

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1510 SLDEPFIQKDVELRIMPPVQENDNG------NETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAM 1583
Cdd:PTZ00449  706 TLPETPGTPFTTPRPLPPKLPRDEEfpfepiGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAE 785

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1584 PTKSSRKAKKPAQTASKLPPPVARKPSqlpvyklLPSQNRLQPQKHVSFTPGDDMPRVYCVE--GTPINFSTATSLSDL- 1660
Cdd:PTZ00449  786 TGEPDEAMKRPDSPSEHEDKPPGDHPS-------LPKKRHRLDGLALSTTDLESDAGRIAKDasGKIVKLKRSKSFDDLt 858

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 53759122  1661 TIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQ 1701
Cdd:PTZ00449  859 TVEEAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVR 899
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1371-1393 3.50e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.97  E-value: 3.50e-03
                           10        20
                   ....*....|....*....|....
gi 53759122   1371 SPPEHY-VQETPLMFSRCTSVSSL 1393
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1257-1274 6.63e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.20  E-value: 6.63e-03
                           10
                   ....*....|....*...
gi 53759122   1257 ETIQTYCVEDTPICFSRC 1274
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 340-392 8.68e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 8.68e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 53759122     340 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 392
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
Arm_APC_u3 pfam16629
Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately ...
 732-1019 1.19e-166

Armadillo-associated region on APC; Arm_APC_u3 is a semi-unstructured region lying immediately downstream of the armadillo fold before the beta-catenin binding motifs, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435476  Cd Length: 293  Bit Score: 515.29  E-value: 1.19e-166
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    732 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDN-- 809
Cdd:pfam16629    1 NRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRNKQRHKQNVYSEYVLDSGRHDDSvc 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    810 RSDNFNTGNMTVLSPYLNTTVLPSSSSSRG--SLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKR-GLQISTTAAQ 886
Cdd:pfam16629   81 RSDNFNTGNVTVLSPYLNTTVLPSSSSRDSrgNAESSRSEKDRSLDRERGAGLSNFHPATENSGNSSKRiGMQISTTAAQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    887 IAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNS 966
Cdd:pfam16629  161 IAKVMEEVSSMHISQEDRSSGSTSDMHCMQDDRNSIRRSSTAHPHSNVYSFNKSESSNRPCPMPYMKMEYKRASNDSLNS 240

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 53759122    967 VSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDG 1019
Cdd:pfam16629  241 VSSSDGYGKRGQMKPSVESYSEDDEGKFCSYGKYPADLAHKIHSANHMDDNDG 293
APC_basic pfam05956
APC basic domain; This region of the APC family of proteins is known as the basic domain. It ...
 2223-2568 4.77e-110

APC basic domain; This region of the APC family of proteins is known as the basic domain. It contains a high proportion of positively charged amino acids and interacts with microtubules.


Pssm-ID: 428690 [Multi-domain]  Cd Length: 336  Bit Score: 354.95  E-value: 4.77e-110
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2223 SISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTS-PRGAKPSVKSELSPVARQTSQIGGSSKAPSR 2301
Cdd:pfam05956    1 VVFRGRTVIYMPGVKESQPSTSPPPKKTPPKTDAPAKNPNLGQQRSRSlHRLGKPSELADLSPPKRSATPPARISKAPSS 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2302 SGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNgisppnKLSQLPRTSSPSTASTKSSGSgKMSYTSPGRQMSQQNLTKQ 2381
Cdd:pfam05956   81 GSSRDSTPSRPPQKKLTSPSQSPGRLPGSGGRN------KLSPLPKTKSPARASTKKSGS-HKTQKSPVRIPFMQTPTKQ 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2382 TGLSKNASSI------PRSESASKGLNqmnngNGANKKVELSRMSSTKSSGSESDRSerpVLVRQSTFIKEAPSPTLRRK 2455
Cdd:pfam05956  154 TGLPRNPSPLvtnqpePRSESASKGLR-----SLPGKRLDLVRMSSARSSGSESDRS---GFLRQLTFIKESPSLLLRRR 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2456 LEESASfESLSPSSRPASPTRSQaqtpvlsPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSES 2535
Cdd:pfam05956  226 LELSAS-ESLSPSSQPASPRRSR-------PGLPAVFLCSSRCQELKGWRKQPPNPNSRAEPSDRPLTRRRPPRRTSSES 297

                          330       340       350
                   ....*....|....*....|....*....|...
gi 53759122   2536 PSRLPInRSGTWKREHSKHSSSLPRVSTWRRTG 2568
Cdd:pfam05956  298 PSRLPV-RNGTWKRETFKRYSSLPHINVWRRTG 329
EB1_binding pfam05937
EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the ...
 2670-2843 5.04e-90

EB-1 Binding Domain; This region, found at the C-terminus of the APC proteins, binds the microtubule-associating protein EB-1. At the C-terminus of the alignment is also a pfam00595 binding domain. A short motif in the middle of the region appears to be found in the APC2 proteins.


Pssm-ID: 399141  Cd Length: 174  Bit Score: 290.36  E-value: 5.04e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2670 RSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVS 2749
Cdd:pfam05937    1 RSGRSPTGNTPPVIDSVPEKGIKDEKDSKDPQAKQNMGNGNVPVRTVGLENRLNSFIQSDSPDKKGTETKPLQNNPVPTP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2750 ETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQ 2829
Cdd:pfam05937   81 ETNENPVSERTPFSSSSSSKHSSPSGAVAARVTPFNYNPSPRKSSADSSSARPSQIPTPVNNSTKKRDSKTESTDSSGNQ 160

                          170
                   ....*....|....
gi 53759122   2830 SPKRHSGSYLVTSV 2843
Cdd:pfam05937  161 SPKRHSGSYLVTSV 174
APC_u5 pfam16630
Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of ...
 1036-1135 9.49e-57

Unstructured region on APC between 1st and 2nd catenin-bdg motifs; APC_u5 is a short region of natively unstructured sequence lying between the first and the second 15-residue beta-catenin binding motifs, APC_15aa, pfam05972, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406923  Cd Length: 100  Bit Score: 192.04  E-value: 9.49e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   1036 LNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRV 1115
Cdd:pfam16630    1 LNSGRQSPSQNERWARPKHIIEDEMKQSEQRQPRSQSTTYPVYTESGDDKHMKFQPRFGQQECVSPFRSRGSNGSEQSRV 80

                           90       100
                   ....*....|....*....|
gi 53759122   1116 GSNHGINQNVSQSLCQEDDY 1135
Cdd:pfam16630   81 GSSHGINQKVSQSLCQVDDY 100
APC_u14 pfam16635
Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively ...
 1746-1839 5.89e-47

Unstructured region on APC between SAMP and APC_crr; APC_u14 is a short region of natively unstructured sequence lying between the second SAMP pfam05924, and the fifth creatine-rich region, APC_crr, pfam05923, on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435479  Cd Length: 94  Bit Score: 163.86  E-value: 5.89e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   1746 IMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFND 1825
Cdd:pfam16635    1 IMDQIQQASAASSGGSKSQQDGEKKKPTSPVKPMPQSSEYRARVRKNTESKNNLNSERSYPDNKESKKQNLKNNSRDFND 80

                           90
                   ....*....|....
gi 53759122   1826 KLPNNEDRVRGSFA 1839
Cdd:pfam16635   81 KLPNNEERTRGSFA 94
APC_rep pfam18797
Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo ...
 393-466 5.39e-45

Adenomatous polyposis coli (APC) repeat; Adenomatous polyposis coli contains an armadillo repeat and uses its highly conserved surface groove to recognize the APC-binding region (ABR) of Asef. This entry represents a single repeat unit of the Armadillo region.


Pssm-ID: 465870  Cd Length: 74  Bit Score: 157.32  E-value: 5.39e-45
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 53759122    393 SQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAM 466
Cdd:pfam18797    1 SQPDDKRGRREMRVLHLLEQIRAYCETCWDWQESHSRGPEGDSNPMPSPIEHQICPAICALMKLSFDEEHRHAM 74
APC_u9 pfam16633
Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of ...
 1283-1368 1.35e-35

Unstructured region on APC between 1st two creatine-rich regions; APC_u9 is a short region of natively unstructured sequence lying between the first and second APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435478  Cd Length: 89  Bit Score: 131.15  E-value: 1.35e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   1283 AEDEI-GCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLS-SESARHKAVEFSSGAKS 1360
Cdd:pfam16633    2 AEDEIeGRDQATRSTDNYNTLQITELKENSGAVSTEQTVSEVPSSSQHIRTKPNRLQASNLSpSDSSRHKAVEFSSGAKS 81


                   ....*...
gi 53759122   1361 PSKSGAQT 1368
Cdd:pfam16633   82 PSKSGAQT 89
APC_u15 pfam16636
Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of ...
 1873-1947 2.75e-31

Unstructured region on APC between APC_crr regions 5 and 6; APC_u15 is a short region of natively unstructured sequence lying between the fifth and sixth creatine-rich, APC_crr, pfam05923, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 435480  Cd Length: 81  Bit Score: 118.81  E-value: 2.75e-31
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 53759122   1873 DLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAAT 1947
Cdd:pfam16636    7 DLSREKAELRKGKETKETETKVTSHIEQPSNQQSTNRTQACQKHPPNRGQPKPLLQKQTTFPQSSKDIPDRGAAT 81
APC_u13 pfam16634
Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively ...
 1662-1715 1.15e-24

Unstructured region on APC between APC_crr and SAMP; APC_u13 is a short region of natively unstructured sequence lying between the fourth creatine-rich region, APC_crr, pfam05923, and the SAMP pfam05924, domains on APC or adenomatous polyposis coli proteins in higher eukaryotes. The function is not known.


Pssm-ID: 406927  Cd Length: 54  Bit Score: 98.71  E-value: 1.15e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 53759122   1662 IESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDD 1715
Cdd:pfam16634    1 IESPPNELANAESTGTGAESAEFEKRDTIPTEGRSTDDAQRGKKSNITTSALDD 54
Suppressor_APC pfam11414
Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has ...
 127-207 4.83e-22

Adenomatous polyposis coli tumour suppressor protein; The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.


Pssm-ID: 463275  Cd Length: 82  Bit Score: 92.32  E-value: 4.83e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    127 SRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTE-NFSLQTDMTRRQLEYEARQIRVAMEEQLG 205
Cdd:pfam11414    1 DYNMLKRMKQLEQEKDVLLQGLEMVERARDWYQQQLQEVQERQKYLGANGtYFDYGSDAQQERLEFLLARIQEVNRCLGG 80


                   ..
gi 53759122    206 TC 207
Cdd:pfam11414   81 LI 82
APC_N_CC pfam16689
Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil ...
 4-55 6.55e-22

Coiled-coil N-terminus of APC, dimerization domain; APC_N_CC is the N-terminal, coiled-coil dimerization domain of the adenomatosis polyposis coli (APC) tumour-repressor proteins. It plays a key role in the regulation of cellular levels of the oncogene product beta-catenin. Coiled-coil regions are binding repeats that in this case bind to the armadillo repeat region of beta-catenin.


Pssm-ID: 435517  Cd Length: 52  Bit Score: 90.82  E-value: 6.55e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 53759122      4 ASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI 55
Cdd:pfam16689    1 ASYDQLLRQVEALKLENTTLRQELRDNSSHLSKLETEASNMKEVLKHLQGSI 52
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1637-1660 1.46e-07

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 49.30  E-value: 1.46e-07
                           10        20
                   ....*....|....*....|....
gi 53759122   1637 DMPRVYCVEGTPINFSTATSLSDL 1660
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRASSLSSL 24
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 4.98e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 48.19  E-value: 4.98e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 53759122     649 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 689
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 6.26e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 6.26e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 53759122    649 NEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSA 689
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2251-2564 9.57e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.94  E-value: 9.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2251 PPLKTPASKsPSEGQTATTSPRGAKPSVKSE----LSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGR 2326
Cdd:PHA03247 2703 PPPPTPEPA-PHALVSATPLPPGPAAARQASpalpAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2327 NSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGrqmsqqnltkqTGLSKNASSIPRSESASKGLNQ--M 2404
Cdd:PHA03247 2782 RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPA-----------GPLPPPTSAQPTAPPPPPGPPPpsL 2850

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2405 NNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRqstfikeAPSPTLRRKLEESA-SFESLSPSSRPASPTRSQAQTPV 2483
Cdd:PHA03247 2851 PLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRR-------LARPAVSRSTESFAlPPDQPERPPQPQAPPPPQPQPQP 2923

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2484 LSPSLPDMSLSTHSSVQAggwrKLPPNLSPTieyNDGRPAKRHDIARSHSESPSRLPINRSGTWK----RE------HSK 2553
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQP----PLAPTTDPA---GAGEPSGAVPQPWLGALVPGRVAVPRFRVPQpapsREapasstPPL 2996

                         330
                  ....*....|.
gi 53759122  2554 HSSSLPRVSTW 2564
Cdd:PHA03247 2997 TGHSLSRVSSW 3007
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2256-2401 5.75e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 52.10  E-value: 5.75e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2256 PASKSPSEGQTATTSPRGAKPSVKSELSPVA----RQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISP 2331
Cdd:PHA03307  278 PSSRPGPASSSSSPRERSPSPSPSSPGSGPApsspRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPP 357

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2332 GRNGISPPNKLSQlPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGL 2401
Cdd:PHA03307  358 PPADPSSPRKRPR-PSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAF 426
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 2033-2052 3.90e-05

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 42.58  E-value: 3.90e-05
                           10        20
                   ....*....|....*....|
gi 53759122   2033 DSEDDLLQECISSAMPKKKK 2052
Cdd:pfam05924    3 DDEDDLLQECINSAMPKKRR 22
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2249-2544 4.12e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.40  E-value: 4.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2249 KGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVAR----------QTSQIGGSSKAPSRSGSRDSTPS-------R 2311
Cdd:PHA03307  101 AREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRpvgspgpppaASPPAAGASPAAVASDAASSRQAalplsspE 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2312 PAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKmSYTSPGRQMSQQNLTKQTGLSKNASSI 2391
Cdd:PHA03307  181 ETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDA-GASSSDSSSSESSGCGWGPENECPLPR 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2392 PRSESASKGLNQMNNGNGankkvelSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTlRRKLEESASFESLSPSSRP 2471
Cdd:PHA03307  260 PAPITLPTRIWEASGWNG-------PSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSP-RASSSSSSSRESSSSSTSS 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2472 ASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEY---NDGRP---AKRHDIARSH--SESPSRLPINR 2543
Cdd:PHA03307  332 SSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSpaaSAGRPtrrRARAAVAGRArrRDATGRFPAGR 411


                  .
gi 53759122  2544 S 2544
Cdd:PHA03307  412 P 412
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
134-266 2.49e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 46.68  E-value: 2.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  134 LEELEKERSLLLADLDKEEKEKDWY--YAQLQNLTKRIDSLP---------LTENFSLQTDM---------TRRQLEYEA 193
Cdd:COG4717  104 LEELEAELEELREELEKLEKLLQLLplYQELEALEAELAELPerleeleerLEELRELEEELeeleaelaeLQEELEELL 183

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53759122  194 RQIRVAMEEQLgtcQDMEKRAQRRIARIQQIEKDILRIRQLLQsQATEAERSSQNKHETGsHDAERQNEGQGV 266
Cdd:COG4717  184 EQLSLATEEEL---QDLAEELEELQQRLAELEEELEEAQEELE-ELEEELEQLENELEAA-ALEERLKEARLL 251
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 8-272 3.60e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 46.20  E-value: 3.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122      8 QLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDeamassgqidLLERLKELNLDSSNFPGVKL 87
Cdd:TIGR02168  744 QLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ----------LKEELKALREALDELRAELT 813

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122     88 RSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRES-TGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLT 166
Cdd:TIGR02168  814 LLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESlAAEIEELEELIEELESELEALLNERASLEEALALLR 893

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    167 KRIDSLpltenfslqtDMTRRQLEYEARQIRVAMEEqlgtCQDMEKRAQRRIARIQQIEKDIL-RIRQLLQSQATEAERs 245
Cdd:TIGR02168  894 SELEEL----------SEELRELESKRSELRRELEE----LREKLAQLELRLEGLEVRIDNLQeRLSEEYSLTLEEAEA- 958

                          250       260       270
                   ....*....|....*....|....*....|..
gi 53759122    246 SQNKHETGSHDAERQ-----NEGQGVGEINMA 272
Cdd:TIGR02168  959 LENKIEDDEEEARRRlkrleNKIKELGPVNLA 990
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-553 5.57e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.72  E-value: 5.57e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 53759122     512 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLSW 553
Cdd:smart00185    1 DDENKQAVVDA-GGLPALVELLKSEDEEVVKEAAWALSNLSS 41
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 2254-2514 6.01e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 45.34  E-value: 6.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2254 KTPASKSPSEGQTATTSPRGAKPsvkselSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPgr 2333
Cdd:pfam17823  151 RANASAAPRAAIAAASAPHAASP------APRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHP-- 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2334 ngiSPPNKLSQLPrTSSPStASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSiPRSESASKGLNQMNNGNGANKk 2413
Cdd:pfam17823  223 ---AAGTALAAVG-NSSPA-AGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGD-PHARRLSPAKHMPSDTMARNP- 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   2414 veLSRMSSTKSSGSESDRSERPVLvrqSTFIKEAPSPTlRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPsLPDMSL 2493
Cdd:pfam17823  296 --AAPMGAQAQGPIIQVSTDQPVH---NTAGEPTPSPS-NTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASP-VPVLHT 368

                          250       260
                   ....*....|....*....|.
gi 53759122   2494 STHSSVQAGGWRKLPPNLSPT 2514
Cdd:pfam17823  369 SMIPEVEATSPTTQPSPLLPT 389
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 512-552 6.04e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 6.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 53759122    512 DVANKATLCSMkGCMRALVAQLKSESEDLQQVIASVLRNLS 552
Cdd:pfam00514    1 SPENKQAVIEA-GAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 691-731 7.00e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 7.00e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 53759122    691 NPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMA 731
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 135-262 1.06e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  135 EELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfslqtDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRA 214
Cdd:COG1196  221 ELKELEAELLLLKLRELEAELEELEAELEELEAELEEL----------EAELAELEAELEELRLELEELELELEEAQAEE 290

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 53759122  215 QRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNE 262
Cdd:COG1196  291 YELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEE 338
SAMP pfam05924
SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1716-1737 1.46e-03

SAMP Motif; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). This motif binds axin.


Pssm-ID: 461782  Cd Length: 22  Bit Score: 37.96  E-value: 1.46e-03
                           10        20
                   ....*....|....*....|..
gi 53759122   1716 NKAEEGDILAECINSAMPKGKS 1737
Cdd:pfam05924    1 SPDDEDDLLQECINSAMPKKRR 22
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 11-247 1.61e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 1.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   11 KQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSI---EDEAMASSGQIDLLE-RLKELNLDSSnfpgvK 86
Cdd:COG4942   20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIaalARRIRALEQELAALEaELAELEKEIA-----E 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122   87 LRSKM-SLRSYGSREGSVSSRSGECSPvPMGSFPRRGFVNGSRESTgYLEELEKERSLLLADLDKEEKEKDWYYAQLQNL 165
Cdd:COG4942   95 LRAELeAQKEELAELLRALYRLGRQPP-LALLLSPEDFLDAVRRLQ-YLKYLAPARREQAEELRADLAELAALRAELEAE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  166 TKRIDSLpltenfslqtdmtRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERS 245
Cdd:COG4942  173 RAELEAL-------------LAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239


                 ..
gi 53759122  246 SQ 247
Cdd:COG4942  240 AE 241
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 134-259 2.20e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.90  E-value: 2.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    134 LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSL------------PLTENFSLQTDMTRRQLEYEARQIRVAME 201
Cdd:TIGR02169  232 KEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIeqlleelnkkikDLGEEEQLRVKEKIGELEAEIASLERSIA 311

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 53759122    202 EqlgtCQDMEKRAQRRIARIQ-QIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAER 259
Cdd:TIGR02169  312 E----KERELEDAEERLAKLEaEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEEL 366
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 120-260 2.28e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.51  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122    120 RRGFVNGSRESTGY--------LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfslqtdmtrRQLEY 191
Cdd:TIGR02168  657 PGGVITGGSAKTNSsilerrreIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQL--------------RKELE 722

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53759122    192 EARQIRVAMEEQLGTcqdMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQ 260
Cdd:TIGR02168  723 ELSRQISALRKDLAR---LEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE 788
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 1291-1701 3.27e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1291 QTTQEAD---SANTLQIAEIKEKIGTRSAEDPvsEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQ 1367
Cdd:PTZ00449  480 QFTQEIKkliKKSKKKLAPIEEEDSDKHDEPP--EGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEV 557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1368 TPKSPP--EHYVQETPLMFSRCT----SVSSLDSFESRSIASSVQ-SEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPP 1440
Cdd:PTZ00449  558 GKKPGPakEHKPSKIPTLSKKPEfpkdPKHPKDPEEPKKPKRPRSaQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1441 PPPQTAQTKR-EVPK----NKAPTAEKRESGPK------QAAVNAAVQRVQvlpdadtllhfaTESTPDGFSCSSSLSAL 1509
Cdd:PTZ00449  638 PPQRPSSPERpEGPKiiksPKPPKSPKPPFDPKfkekfyDDYLDAAAKSKE------------TKTTVVLDESFESILKE 705

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1510 SLDEPFIQKDVELRIMPPVQENDNG------NETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAM 1583
Cdd:PTZ00449  706 TLPETPGTPFTTPRPLPPKLPRDEEfpfepiGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEDIHAE 785

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  1584 PTKSSRKAKKPAQTASKLPPPVARKPSqlpvyklLPSQNRLQPQKHVSFTPGDDMPRVYCVE--GTPINFSTATSLSDL- 1660
Cdd:PTZ00449  786 TGEPDEAMKRPDSPSEHEDKPPGDHPS-------LPKKRHRLDGLALSTTDLESDAGRIAKDasGKIVKLKRSKSFDDLt 858

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 53759122  1661 TIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQ 1701
Cdd:PTZ00449  859 TVEEAEEMGAEARKIVVDDDGTEADDEDTHPPEEKHKSEVR 899
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2252-2568 3.33e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2252 PLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQiGGSSKAPSRSGsrDSTPSRPAQQPLSRPIQSPGRNSISP 2331
Cdd:PHA03307   63 DRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAR-EGSPTPPGPSS--PDPPPPTPPPASPPPSPAPDLSEMLR 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2332 GRNGISPPNKLSQLPRTSSPS-TASTKSSGSGKM---------SYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGL 2401
Cdd:PHA03307  140 PVGSPGPPPAASPPAAGASPAaVASDAASSRQAAlplsspeetARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASS 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2402 NQMNNGNGANKKVELSRMSSTKSSGSESD---RSERPVLVRQSTfikeaPSPTLRRKLEESASFESLSPSSRPASPTRSQ 2478
Cdd:PHA03307  220 PAPAPGRSAADDAGASSSDSSSSESSGCGwgpENECPLPRPAPI-----TLPTRIWEASGWNGPSSRPGPASSSSSPRER 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2479 AqtPVLSPSLPDMSLSTHSSVQAGGWRKLPP-NLSPTIEYNDGRPAKRHDIARSHSESPS----RLPINRSGTWKREHSK 2553
Cdd:PHA03307  295 S--PSPSPSSPGSGPAPSSPRASSSSSSSREsSSSSTSSSSESSRGAAVSPGPSPSRSPSpsrpPPPADPSSPRKRPRPS 372

                         330
                  ....*....|....*
gi 53759122  2554 HSSSLPRVSTWRRTG 2568
Cdd:PHA03307  373 RAPSSPAASAGRPTR 387
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1371-1393 3.50e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.97  E-value: 3.50e-03
                           10        20
                   ....*....|....*....|....
gi 53759122   1371 SPPEHY-VQETPLMFSRCTSVSSL 1393
Cdd:pfam05923    1 DSPKRYcVEGTPANFSRASSLSSL 24
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 134-248 5.69e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.67  E-value: 5.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  134 LEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLpltenfslqtdmtrrqleyeARQIRvAMEEQLgtcQDMEKR 213
Cdd:COG4942   29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAAL--------------------ARRIR-ALEQEL---AALEAE 84

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 53759122  214 AQRRIARIQQIEKDILRIRQLLQSQATEAERSSQN 248
Cdd:COG4942   85 LAELEKEIAELRAELEAQKEELAELLRALYRLGRQ 119
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2250-2540 6.23e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2250 GPPLKTPASKSPSEGQTATTSPRGAKPSvkselsPVARQTSqIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSI 2329
Cdd:PHA03247 2603 DDRGDPRGPAPPSPLPPDTHAPDPPPPS------PSPAANE-PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQ 2675

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2330 SPgrngiSPPNKLSQ--LPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNG 2407
Cdd:PHA03247 2676 AS-----SPPQRPRRraARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPAT 2750

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53759122  2408 NGANKKVE--------LSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPT--LRRKLEESASFESLSPSSRPAS---- 2473
Cdd:PHA03247 2751 PGGPARPArppttagpPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWdpADPPAAVLAPAAALPPAASPAGplpp 2830

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53759122  2474 PTRSQAQTPVLSPSLPDMSLSTHSSVQAGG--WRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLP 2540
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPSLPLGGSVAPGGdvRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFA 2899
APC_r pfam05923
APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis ...
 1257-1274 6.63e-03

APC repeat; This short region is found repeated in the mid region of the adenomatous polyposis proteins (APCs). In the human protein many cancer-linked SNPs are found near the first three occurrences of the motif. These repeats bind beta-catenin.


Pssm-ID: 461781  Cd Length: 24  Bit Score: 36.20  E-value: 6.63e-03
                           10
                   ....*....|....*...
gi 53759122   1257 ETIQTYCVEDTPICFSRC 1274
Cdd:pfam05923    1 DSPKRYCVEGTPANFSRA 18
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 340-392 8.68e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 8.68e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 53759122     340 SQDSCISMRQSGCLPLLIQLLHgndkdsvllgnsRGSKEARARASAALHNIIH 392
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLK------------SEDEEVVKEAAWALSNLSS 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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