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Conserved domains on  [gi|4557323|ref|NP_000031|]
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apolipoprotein C-III precursor [Homo sapiens]

Protein Classification

Apo-CIII domain-containing protein( domain architecture ID 10530661)

Apo-CIII domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Apo-CIII pfam05778
Apolipoprotein CIII (Apo-CIII); This family consists of several mammalian apolipoprotein CIII ...
22-90 8.00e-38

Apolipoprotein CIII (Apo-CIII); This family consists of several mammalian apolipoprotein CIII (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue glycoprotein. It is synthesized in the intestine and liver as part of the very low density lipoprotein (VLDL) and the high density lipoprotein (HDL) particles. Owing to its positive correlation with plasma triglyceride (Tg) levels, Apo-CIII is suggested to play a role in Tg metabolism and is therefore of interest regarding atherosclerosis. However, unlike other apolipoproteins such as Apo-AI, Apo E or CII for which many naturally occurring mutations are known, the structure-function relationships of apo C-III remains a subject of debate. One possibility is that apo C-III inhibits lipoprotein lipase (LPL) activity, as shown by in vitro experiments. Another suggestion, is that elevated levels of Apo-CIII displace other apolipoproteins at the lipoprotein surface, modifying their clearance from plasma.


:

Pssm-ID: 461737  Cd Length: 69  Bit Score: 121.45  E-value: 8.00e-38
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4557323    22 EAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPE 90
Cdd:pfam05778  1 EAEDASLLGVMQGYMQQATKTAQDALTSVQESQVAQQARGWMTDGFSSLKDYWSTFTGKFSGFWDSTPE 69
 
Name Accession Description Interval E-value
Apo-CIII pfam05778
Apolipoprotein CIII (Apo-CIII); This family consists of several mammalian apolipoprotein CIII ...
22-90 8.00e-38

Apolipoprotein CIII (Apo-CIII); This family consists of several mammalian apolipoprotein CIII (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue glycoprotein. It is synthesized in the intestine and liver as part of the very low density lipoprotein (VLDL) and the high density lipoprotein (HDL) particles. Owing to its positive correlation with plasma triglyceride (Tg) levels, Apo-CIII is suggested to play a role in Tg metabolism and is therefore of interest regarding atherosclerosis. However, unlike other apolipoproteins such as Apo-AI, Apo E or CII for which many naturally occurring mutations are known, the structure-function relationships of apo C-III remains a subject of debate. One possibility is that apo C-III inhibits lipoprotein lipase (LPL) activity, as shown by in vitro experiments. Another suggestion, is that elevated levels of Apo-CIII displace other apolipoproteins at the lipoprotein surface, modifying their clearance from plasma.


Pssm-ID: 461737  Cd Length: 69  Bit Score: 121.45  E-value: 8.00e-38
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4557323    22 EAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPE 90
Cdd:pfam05778  1 EAEDASLLGVMQGYMQQATKTAQDALTSVQESQVAQQARGWMTDGFSSLKDYWSTFTGKFSGFWDSTPE 69
 
Name Accession Description Interval E-value
Apo-CIII pfam05778
Apolipoprotein CIII (Apo-CIII); This family consists of several mammalian apolipoprotein CIII ...
22-90 8.00e-38

Apolipoprotein CIII (Apo-CIII); This family consists of several mammalian apolipoprotein CIII (Apo-CIII) sequences. Apolipoprotein C-III is a 79-residue glycoprotein. It is synthesized in the intestine and liver as part of the very low density lipoprotein (VLDL) and the high density lipoprotein (HDL) particles. Owing to its positive correlation with plasma triglyceride (Tg) levels, Apo-CIII is suggested to play a role in Tg metabolism and is therefore of interest regarding atherosclerosis. However, unlike other apolipoproteins such as Apo-AI, Apo E or CII for which many naturally occurring mutations are known, the structure-function relationships of apo C-III remains a subject of debate. One possibility is that apo C-III inhibits lipoprotein lipase (LPL) activity, as shown by in vitro experiments. Another suggestion, is that elevated levels of Apo-CIII displace other apolipoproteins at the lipoprotein surface, modifying their clearance from plasma.


Pssm-ID: 461737  Cd Length: 69  Bit Score: 121.45  E-value: 8.00e-38
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4557323    22 EAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPE 90
Cdd:pfam05778  1 EAEDASLLGVMQGYMQQATKTAQDALTSVQESQVAQQARGWMTDGFSSLKDYWSTFTGKFSGFWDSTPE 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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