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Conserved domains on  [gi|4503895|ref|NP_000145|]
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galactokinase [Homo sapiens]

Protein Classification

galactokinase( domain architecture ID 11414964)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
12-390 2.14e-178

Galactokinase [Carbohydrate transport and metabolism];


:

Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 501.22  E-value: 2.14e-178
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   12 LLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTtsegADEPQRLQFP 91
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYS----ADFDEEVEFD 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   92 LPtaqrSLEPG-TPRWANYVKGVIQYYPAA--PLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQ 168
Cdd:COG0153  77 LD----DLEPGeEDGWANYVRGVAWALQERgyKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAK 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895  169 VCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVAR 248
Cdd:COG0153 153 IGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAA 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895  249 ALGKESLREVQLEELEAARDLVSKEG-FRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPELDQ 327
Cdd:COG0153 233 ILGVKSLRDVTLEDLEAARARLGDEVlRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDT 312

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4503895  328 LVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHY----GGTATFYLSQAADGAKVL 390
Cdd:COG0153 313 LVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYaektGLEPDFYVVKPSDGARRL 379
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
12-390 2.14e-178

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 501.22  E-value: 2.14e-178
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   12 LLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTtsegADEPQRLQFP 91
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYS----ADFDEEVEFD 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   92 LPtaqrSLEPG-TPRWANYVKGVIQYYPAA--PLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQ 168
Cdd:COG0153  77 LD----DLEPGeEDGWANYVRGVAWALQERgyKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAK 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895  169 VCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVAR 248
Cdd:COG0153 153 IGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAA 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895  249 ALGKESLREVQLEELEAARDLVSKEG-FRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPELDQ 327
Cdd:COG0153 233 ILGVKSLRDVTLEDLEAARARLGDEVlRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDT 312

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4503895  328 LVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHY----GGTATFYLSQAADGAKVL 390
Cdd:COG0153 313 LVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYaektGLEPDFYVVKPSDGARRL 379
PRK05101 PRK05101
galactokinase; Provisional
 12-390 2.04e-136

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 394.68  E-value: 2.04e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    12 LLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTtsegAD-EPQRLQF 90
Cdd:PRK05101   3 LKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIA----ADyDNQQDEF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    91 PLptaQRSLEP-GTPRWANYVKGVIQYYPA--APLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQL--CPDSGTIAA 165
Cdd:PRK05101  79 SL---DAPIVPhPEQQWANYVRGVVKHLQErnPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLyhLPLSGAEIA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   166 raQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLsdPK-LAVLITNSNVRHSLASSEYPVRRRQCE 244
Cdd:PRK05101 156 --LNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPM--PEgVAVVIINSNVKRGLVDSEYNTRRQQCE 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   245 EVARALGKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPE 324
Cdd:PRK05101 232 TAARFFGVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQ 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4503895   325 LDQLVEAALAVPGVYGS-RMTGGGFGGCTVTLLEASAAPHAMRHIQEHY----GGTATFYLSQAADGAKVL 390
Cdd:PRK05101 312 IDTLVEIVKAVIGDQGGvRMTGGGFGGCIVALVPEELVEAVRQAVAEQYeaktGLKETFYVCKASQGAGQC 382
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 15-390 7.85e-119

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 350.28  E-value: 7.85e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895     15 EARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTTSEGADEPQR-LQFPLP 93
Cdd:TIGR00131   3 SIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERsLDLPLD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895     94 TAQRSlepgtpRWANYVKGVI----QYYPAAPLpGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCP---DSGTIAAR 166
Cdd:TIGR00131  83 GSEVS------DWANYFKGVLhvaqERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHlplDSKQILLR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    167 AQVcqqAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEV 246
Cdd:TIGR00131 156 IQV---AENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    247 ARALGKES---LREVQLEEL---EAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEV 320
Cdd:TIGR00131 233 ANFLAATDkgaLRDFMNEYFaryIARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYEC 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4503895    321 SCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHY----GGTATFYLSQAADGAKVL 390
Cdd:TIGR00131 313 TCPEIDELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYpkktGLELTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 19-67 1.40e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 89.43  E-value: 1.40e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4503895     19 AFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSP 67
Cdd:pfam10509   2 AFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
12-390 2.14e-178

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 501.22  E-value: 2.14e-178
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   12 LLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTtsegADEPQRLQFP 91
Cdd:COG0153   1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYS----ADFDEEVEFD 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   92 LPtaqrSLEPG-TPRWANYVKGVIQYYPAA--PLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQ 168
Cdd:COG0153  77 LD----DLEPGeEDGWANYVRGVAWALQERgyKLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAK 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895  169 VCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVAR 248
Cdd:COG0153 153 IGQRAENEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAA 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895  249 ALGKESLREVQLEELEAARDLVSKEG-FRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPELDQ 327
Cdd:COG0153 233 ILGVKSLRDVTLEDLEAARARLGDEVlRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDT 312

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4503895  328 LVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHY----GGTATFYLSQAADGAKVL 390
Cdd:COG0153 313 LVELALAEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYaektGLEPDFYVVKPSDGARRL 379
PRK05101 PRK05101
galactokinase; Provisional
 12-390 2.04e-136

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 394.68  E-value: 2.04e-136
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    12 LLAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTtsegAD-EPQRLQF 90
Cdd:PRK05101   3 LKQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIA----ADyDNQQDEF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    91 PLptaQRSLEP-GTPRWANYVKGVIQYYPA--APLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQL--CPDSGTIAA 165
Cdd:PRK05101  79 SL---DAPIVPhPEQQWANYVRGVVKHLQErnPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLyhLPLSGAEIA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   166 raQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLsdPK-LAVLITNSNVRHSLASSEYPVRRRQCE 244
Cdd:PRK05101 156 --LNGQEAENQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPM--PEgVAVVIINSNVKRGLVDSEYNTRRQQCE 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   245 EVARALGKESLREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPE 324
Cdd:PRK05101 232 TAARFFGVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQ 311

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4503895   325 LDQLVEAALAVPGVYGS-RMTGGGFGGCTVTLLEASAAPHAMRHIQEHY----GGTATFYLSQAADGAKVL 390
Cdd:PRK05101 312 IDTLVEIVKAVIGDQGGvRMTGGGFGGCIVALVPEELVEAVRQAVAEQYeaktGLKETFYVCKASQGAGQC 382
PRK05322 PRK05322
galactokinase; Provisional
 13-390 1.11e-119

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 352.24  E-value: 1.11e-119
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    13 LAEARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLttSEGADEPQRLQFPL 92
Cdd:PRK05322   3 KEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLY--SANFEDLGIIEFDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    93 PTAQRSLEPGtprWANYVKGVIQYYPAAPLP---GFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQV 169
Cdd:PRK05322  81 DDLSFDKEDD---WANYPKGVLKFLQEAGYKidhGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKL 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   170 CQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEVARA 249
Cdd:PRK05322 158 GQKTENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEE 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   250 LGKE----SLREVQLEELEAARDLVSKEG-FRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPE 324
Cdd:PRK05322 238 LQKKldikSLGELTEEEFDEYSYLIKDETlLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLE 317

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   325 LDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHY----GGTATFYLSQAADGAKVL 390
Cdd:PRK05322 318 LDTLVEAAWKQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYeekiGYAASFYVAEIGDGAREL 387
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 15-390 7.85e-119

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 350.28  E-value: 7.85e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895     15 EARRAFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTTSEGADEPQR-LQFPLP 93
Cdd:TIGR00131   3 SIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERsLDLPLD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895     94 TAQRSlepgtpRWANYVKGVI----QYYPAAPLpGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCP---DSGTIAAR 166
Cdd:TIGR00131  83 GSEVS------DWANYFKGVLhvaqERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHlplDSKQILLR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    167 AQVcqqAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPKLAVLITNSNVRHSLASSEYPVRRRQCEEV 246
Cdd:TIGR00131 156 IQV---AENHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    247 ARALGKES---LREVQLEEL---EAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEV 320
Cdd:TIGR00131 233 ANFLAATDkgaLRDFMNEYFaryIARLTKMLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYEC 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4503895    321 SCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHY----GGTATFYLSQAADGAKVL 390
Cdd:TIGR00131 313 TCPEIDELVCSAALVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYpkktGLELTFYVIVSKPGAGSC 386
PRK03817 PRK03817
galactokinase; Provisional
 32-390 9.42e-104

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 310.39  E-value: 9.42e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    32 VSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSllttSEGADEPQRLQFplptaqRSLEPgTPRWANYVK 111
Cdd:PRK03817   3 VKSPGRVNLIGEHTDYNDGYVLPFAINLYTFLEIEKSEKFIFY----SENFNEEKTFEL------DKLEK-LNSWADYIK 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   112 GVI-----QYYPAAPLPGFsavVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGMPCGIMD 186
Cdd:PRK03817  72 GVIwvlekRGYEVGGVKGK---VSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMD 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   187 QFISLMGQKGHALLIDCRSLETSLVPLSDpKLAVLITNSNVRHSLASSEYPVRRRQCEEVARALGKESLREVQLEELEAA 266
Cdd:PRK03817 149 QFAVAFGKKDHAIFLDTMTLEYEYVPFPE-DYEILVFDTGVKRELASSEYNERRQECEEALKILGKKSSKEVTEEDLSKL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   267 RDLVskegFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVpGVYGSRMTGG 346
Cdd:PRK03817 228 PPLL----RKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALEL-GAYGARLTGA 302

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 4503895   347 GFGGCTVTLLEASAAPHAMRHIQEHY----GGTATFYLSQAADGAKVL 390
Cdd:PRK03817 303 GFGGSAIALVDKGKFESIGEELLEEYkkrfGIDPKYFVVESSDGVRKI 350
PRK00555 PRK00555
galactokinase; Provisional
 34-361 3.15e-80

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 250.55  E-value: 3.15e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    34 APGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVSLLTTSEGADepqrLQFPLPTAqrslePGTPR-WANYVKG 112
Cdd:PRK00555   7 APGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADGS----ARIPLDTT-----PGQVTgWAAYAAG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   113 VIQYYPAA--PLPGFSAVVVSSVPLGGGLSSSASLEVATytfLQQLCPDSGTIAAR---AQVCQQAEHSFAGMPCGIMDQ 187
Cdd:PRK00555  78 VIWALRGAghPVPGGAMSITSDVEIGSGLSSSAALECAV---LGAVGAATGTRIDRleqARLAQRAENEYVGAPTGLLDQ 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   188 FISLMGQKGHALLIDCRSLETSLVPLsDPK---LAVLITNSNVRHSLASSEYPVRRRQCEEVARALGKESLREVQLEELE 264
Cdd:PRK00555 155 LAALFGAPKTALLIDFRDLTVRPVAF-DPDaagVVLLLMDSRARHRHAGGEYAARRASCERAAADLGVSSLRAVQDRGLA 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   265 AARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVpGVYGSRMT 344
Cdd:PRK00555 234 ALGAIADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRA-GALGARMT 312

                        330
                 ....*....|....*..
gi 4503895   345 GGGFGGCTVTLLEASAA 361
Cdd:PRK00555 313 GGGFGGCVIALVPADRA 329
PLN02521 PLN02521
galactokinase
 12-372 6.11e-47

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 167.19  E-value: 6.11e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    12 LLAEARR-------AFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLvgSPRKDGLVSLLTTSEGADE 84
Cdd:PLN02521  24 LLEEARLryarlkaAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIV--AIRRAEGSKKLRIANVNDK 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    85 PQRLQFPLPTAQrSLEPGTPRWANYV----KGVIQYYPAAP--LP---GFSAVVVSSVPLGGGLSSSASLEVATYTFLQQ 155
Cdd:PLN02521 102 YTTCTFPADPDQ-EVDLANHKWGNYFicgyKGVFEFLKSKGvdVGppvGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMA 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   156 LCPDSGTIAARAQ-VCQQAEHSfaGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLsdPKLAVLItnsnVRHSLASS 234
Cdd:PLN02521 181 ALGLNFTKKEVAQfTCKCERHI--GTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQL--PAGGTFV----IANSLAES 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   235 E--------YPVRRRQCE------------EVARALGK-ESLREVQ-----------------------------LEELE 264
Cdd:PLN02521 253 NkavtaatnYNNRVVECRlaaivlavklgmSAEEAISKvKTLSDVEglcvsfagshgssdpavavkellhegpytAEEIE 332

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   265 A-----ARDLVSKE-----------GFR---RARHVVGEIRRT----AQAAAALRRGDY-RAFGRLMVESHRSLRDDYEV 320
Cdd:PLN02521 333 EilgesLTSIFKNSptslavlkaakHFKlhqRAVHVYSEAKRVhafrDTVSSSLSEEEKlKKLGDLMNESHYSCSVLYEC 412

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4503895   321 SCPELDQLVEAALAvPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHY 372
Cdd:PLN02521 413 SCPELEELVKVCRD-NGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKF 463
PLN02865 PLN02865
galactokinase
 10-390 6.51e-47

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 165.36  E-value: 6.51e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    10 AELLAEARRAFREEFGAEPE--LAVSAPGRVNLIGEHTDYNQGLVLPMALElMTVLVGSPRKDGLVSLLTTSEGADEpqr 87
Cdd:PLN02865   9 ANELDEIRERVAAMSGRNSGevRVVVSPYRICPLGAHIDHQGGTVSAMTIN-KGILLGFVPSGDPEVLLRSAQFEGE--- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    88 LQFPLPTAQRSLEPGTPR------WANYVKGVI---QYYPAAPLPGFSAVVVSSVPL-GGGLSSSASLEVATYTFLQQLC 157
Cdd:PLN02865  85 VRFRVDEIQHPIANVSSDskeesnWGDYARGAVyalQSRGHALSQGITGYISGSEGLdSSGLSSSAAVGVAYLLALENAN 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   158 PDSGTIAARAQVCQQAEHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSDPK------LAVLITNSNVRHSL 231
Cdd:PLN02865 165 NLTVSPEDNIELDRLIENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQpggekpFKILLAFSGLRHAL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   232 ASSE-YPVRRRQCEEVARALGKES--------LREVQLEELEAARDLVSKEGFRRARHVVGEIRRTAQAAAALRRGDYRA 302
Cdd:PLN02865 245 TNKPgYNLRVSECQEAARFLLEASgndeleplLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEE 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   303 FGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSRMTGGGFGGCTVTLLEASAAPHAMRHIQEHY---------- 372
Cdd:PLN02865 325 FGKLISASGLSSIENYECGCEPLIQLYEILLKAPGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYekaqpelasn 404

                        410
                 ....*....|....*....
gi 4503895   373 -GGTATFYLSQAADGAKVL 390
Cdd:PLN02865 405 iNGDKPVLICEAGDCARVL 423
PTZ00290 PTZ00290
galactokinase; Provisional
 13-392 1.38e-43

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 157.68  E-value: 1.38e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    13 LAEARRAFREEFGAEPELAVS------APGRVNLIGEHTDYNQGLVLPMA-LELMTVLVGSPR--KDGLVSLLTTSEGAD 83
Cdd:PTZ00290  15 LSTLKPIFLETFKVENDADVEwllftfAPGRVNFIGEHVDYMGGYVCPAAvLEGCHILVGRVKhfCDHKLRFATETDEHF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    84 EPQRLqfplptaqrSLEPGTPRWANYVKGVIQY--------YPAAPLPGFSAVVVSSVPLGGGLSSSASLEVA------- 148
Cdd:PTZ00290  95 VLDHL---------GGAKHNKAWTTFVRGAATLrlnrlgvaIDAPSLQGVCMVVHGTLPMGAGMSASASFGVAllnaint 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   149 TYTFLQQLCPDS-GTIAA---------RAQVCQQA---EHSFAGMPCGIMDQFISLMGQKGHALLIDCRSLETSLVPLSd 215
Cdd:PTZ00290 166 VVTRRYKGCPTSpGRRYSilppmskeeLIELAKQArriETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHDMT- 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   216 PKL----AVLITNSNVRHSL---ASSEYPVRRRQCEEVARALGKESLREVQLEELEAARD-------------------L 269
Cdd:PTZ00290 245 PLLgdgaCFLLIDSMIKHDLlggTAGMYNTVRSDQEGAQKKIGKHRYRGKPFTFSDLVRNpkkytfdgdvvafmesckpL 324

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   270 VSKEGFRRARHVVGEIRRTAQ------AAAALRRGD-YRAFGRLMVESHRSLRDDYEVSCPELDQLVEAALAVPGVYGSR 342
Cdd:PTZ00290 325 MTPGEFERGTYNIMEQIRTLEfiklndPELPLSREErFRKAGEILNAGHQGMRDLMKITTPELDFIHELINEEKGVAGGR 404

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4503895   343 MTGGGFGGCTVTLLEASAAPHAMRHIQEH----YGGTATFYLSQAADGAKVLCL 392
Cdd:PTZ00290 405 MMGGGFGGCIILLLKKNAVDRVVAHVREKfkarFGVENDVYPVVAGDGAFVVSL 458
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 34-355 7.48e-24

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 99.67  E-value: 7.48e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895     34 APGRVNLIGEHTD-YNQgLVLPMALEL-MTVLVGSPRKDGLVSLLTTSEGADE-PQRLQfplptAQRSLepgtprwanyV 110
Cdd:TIGR00549   1 APGKIILFGEHAVvYGE-PAIAAPIPLrTTVTVIESSDGSFIESDLGRGSLDDaPDELD-----GLKYV----------L 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    111 KGVIQYYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGMPCGImDQFIS 190
Cdd:TIGR00549  65 AEFLSRFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGI-DTATS 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    191 LMgqkGHALLIDCRSLETSLvpLSDPKLAVLITNSNVRHSLAsseypvrrrqcEEVAR-ALGKESLREVQLEELEAardl 269
Cdd:TIGR00549 144 TS---GGPVYFEKGEGEFTK--LISLDGYFVIADTGVSGSTK-----------EAVARvRQLLERFPELIDSIMDA---- 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    270 vskegfrrarhvVGEIrrTAQAAAALRRGDYRAFGRLMVESHrSLRDDYEVSCPELDQLVEAALAVpGVYGSRMTGGGFG 349
Cdd:TIGR00549 204 ------------IGEL--TLEAKAALQDGDVESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKA-GALGAKLTGAGGG 267


                  ....*.
gi 4503895    350 GCTVTL 355
Cdd:TIGR00549 268 GCMIAL 273
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 34-355 1.17e-22

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 96.45  E-value: 1.17e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   34 APGRVNLIGEHTD-YNQGlVLPMALEL-MTVLVgSPRKDGLVSLlttsegadEPQRLQFPLptaqrSLEPGTPRWANYVK 111
Cdd:COG1577   1 APGKLILFGEHAVvYGQP-AIAVAVDRrATVTV-EPSDDDKLRI--------ESPDLGGTL-----DLDPLADAALRYIK 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895  112 GVIQY---YPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLC---PDSGTIAARAQvcqQAEHSFAGMPCGiM 185
Cdd:COG1577  66 AAIEAaleYLGLPLKGFDIEIDSEIPRKRGLGSSAAVAVAVIRALAAFYgveLSKEELFKLAL---EAEKIVHGNPSG-L 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895  186 DQFISLMGqkgHALLIDCRSLETSLVPlsDPKLAVLITNSNVRHSlasseypvrrrqceevaralGKESLREVqleelea 265
Cdd:COG1577 142 DTAASTYG---GPIYYQRGDRAEPLEL--PKNLPLVVGDTGVPAS--------------------TKELVAKV------- 189

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895  266 aRDLVSKEGFRRARHV--VGEIrrTAQAAAALRRGDYRAFGRLMVESHRsLRDDYEVSCPELDQLVEAALAvPGVYGSRM 343
Cdd:COG1577 190 -RKLKERNPELYEAFLeeIGDL--VEEAIEALEEGDLEALGELMNENHG-LLRALGVSTPELDRLVEAARK-AGALGAKL 264

                       330
                ....*....|..
gi 4503895  344 TGGGFGGCTVTL 355
Cdd:COG1577 265 TGAGGGGCVIAL 276
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 19-67 1.40e-22

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 89.43  E-value: 1.40e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4503895     19 AFREEFGAEPELAVSAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSP 67
Cdd:pfam10509   2 AFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PRK03926 PRK03926
mevalonate kinase; Provisional
 33-355 1.26e-15

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 76.63  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    33 SAPGRVNLIGEHTDYNQGLVLPMALELMTVLVGSPRKDGLVsllTTSEGADEPQRLqfplptaqrslepgtprwaNYVKG 112
Cdd:PRK03926   5 SAPGKIYLFGEHAVVYGKPAIACAIDLRTYVRAEFNDDSIY---IESDYGKTGEKH-------------------PYVSA 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   113 VIQ-YYPAAPLPGFSAVVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSGTIAARAQVCQQAEHSFAGMPCGImDQFISL 191
Cdd:PRK03926  63 AIEkMREEADKDGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPT-DTYVST 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   192 MGqkGHALLIDCRSLETslvplsdPKLAVLITNSNVRHSLASSEYPVRRRqceevaralgKESLREVQLEELEAARDLVs 271
Cdd:PRK03926 142 MG--GFVTIPDRKKLPF-------PECGIVVGYTGSSGSTKELVANVRKL----------KEEYPELIEPILSSIGKIS- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   272 kegfRRARHVVgeirrtaqaaaalRRGDYRAFGRLMVESHrSLRDDYEVSCPELDQLVEAALAVpGVYGSRMTGGGFGGC 351
Cdd:PRK03926 202 ----EKGEELI-------------LSGDYVSLGELMNINQ-GLLDALGVSTKELSELIYAARTA-GALGAKITGAGGGGC 262


                 ....
gi 4503895   352 TVTL 355
Cdd:PRK03926 263 MVAL 266
GHMP_kinases_N pfam00288
GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and ...
 128-193 1.07e-10

GHMP kinases N terminal domain; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 395225 [Multi-domain]  Cd Length: 64  Bit Score: 56.79  E-value: 1.07e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4503895    128 VVVSSVPLGGGLSSSASLEVATYTFLQQLCPDSgtiaaRAQVCQQAEHSFAGMPCGIMDQFISLMG 193
Cdd:pfam00288   3 EIESNIPLGAGLGSSAALAVALLLALNELFGLP-----LAKLALEAEELAGGGRGGGMDVAASLYG 63
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 291-372 3.57e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 55.94  E-value: 3.57e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895    291 AAAALRRGDYRAFGRLMVESHRSL--RDDYEVSCPELDQLVEAALAVpgVYGSRMTGGGFGGCTVTLLE-ASAAPHAMRH 367
Cdd:pfam08544   1 LLEALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLEL--GLGAKLSGSGGGPTVFALFKdEDDAEEVARA 78


                  ....*
gi 4503895    368 IQEHY 372
Cdd:pfam08544  79 LREAG 83
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 275-355 9.51e-06

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 47.15  E-value: 9.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4503895   275 FRRARHVVGeirrtaQAAAALRRGDYRAFGRLMVESHRSLRdDYEVSCPELDQLVEAALAVpGVYGSRMTGGGFGGCTVT 354
Cdd:PTZ00298 220 LENYNACVS------EAKEALQKGNLFRVGELMNANHDLCQ-KLTVSCRELDSIVQTCRTY-GALGAKMSGTGRGGLVVA 291


                 .
gi 4503895   355 L 355
Cdd:PTZ00298 292 L 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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