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Conserved domains on  [gi|291190772|ref|NP_000164|]
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platelet glycoprotein Ib alpha chain precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11471445)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-223 8.38e-21

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 8.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  30 EVNCDKRNLTALPPDLPKDT--TILHLSENLLYTFSlATLMPYTRLTQLNLDRCELTKLQVD-GTLPVLGTLDLSHNQLQ 106
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPlGNLTNLEELDLSGNQLT 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 107 SLPLLGQTLPALTVLDVSFNRLTSLPlgALRGLGELQELYLKGNELKTLPPglLTPTPKLEKLSLANNNLTEL---PAGL 183
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLklkELEL 294

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 291190772 184 LNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPW 223
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334
LRRCT smart00082
Leucine rich repeat C-terminal domain;
221-281 2.90e-06

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 2.90e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190772   221 NPWLCNCEILYFRRWLQDnaeNVYVWKQGvdvkamtsnvaSVQCDNSDKF--PVYKYPG--KGCP 281
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPV-----------DLRCASPSSLrgPLLELLHseFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-223 8.38e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 8.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  30 EVNCDKRNLTALPPDLPKDT--TILHLSENLLYTFSlATLMPYTRLTQLNLDRCELTKLQVD-GTLPVLGTLDLSHNQLQ 106
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPlGNLTNLEELDLSGNQLT 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 107 SLPLLGQTLPALTVLDVSFNRLTSLPlgALRGLGELQELYLKGNELKTLPPglLTPTPKLEKLSLANNNLTEL---PAGL 183
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLklkELEL 294

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 291190772 184 LNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPW 223
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
34-205 4.91e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.97  E-value: 4.91e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  34 DKRNLTALPPDLPKDTTILHLSENLLYtfSLATLMPYTrLTQLNLDRCELTKLQvdGTLP-VLGTLDLSHNQLQSLPllg 112
Cdd:PRK15370 207 DNNELKSLPENLQGNIKTLYANSNQLT--SIPATLPDT-IQEMELSINRITELP--ERLPsALQSLDLFHNKISCLP--- 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 113 QTLP-ALTVLDVSFNRLTSLPLGALRGlgeLQELYLKGNELKTLPPGLltpTPKLEKLSLANNNLTELPAGLLNGLENLD 191
Cdd:PRK15370 279 ENLPeELRYLSVYDNSIRTLPAHLPSG---ITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASLPPELQVLD 352

                        170
                 ....*....|....
gi 291190772 192 tllLQENSLYTIPK 205
Cdd:PRK15370 353 ---VSKNQITVLPE 363
LRR_8 pfam13855
Leucine rich repeat;
116-176 3.67e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.67e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 291190772  116 PALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNL 176
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-174 4.15e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 4.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  27 SHLevNCDKRNLTALP-PDLPKDTTILHLSENLLYtfSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHN-- 103
Cdd:cd21340    5 THL--YLNDKNITKIDnLSLCKNLKVLYLYDNKIT--KIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNri 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 104 ----------QLQSLPLLGQTLPA-----------------LTVLDVSFNRLTSlpLGALRGLGELQELYLKGNELKTLP 156
Cdd:cd21340   81 svveglenltNLEELHIENQRLPPgekltfdprslaalsnsLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLE 158

                        170       180
                 ....*....|....*....|
gi 291190772 157 P--GLLTPTPKLEKLSLANN 174
Cdd:cd21340  159 EllDLLSSWPSLRELDLTGN 178
LRRNT smart00013
Leucine rich repeat N-terminal domain;
19-50 1.88e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 47.31  E-value: 1.88e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 291190772    19 ICEVSKVASHLEVNCDKRNLTALPPDLPKDTT 50
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRCT smart00082
Leucine rich repeat C-terminal domain;
221-281 2.90e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 2.90e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190772   221 NPWLCNCEILYFRRWLQDnaeNVYVWKQGvdvkamtsnvaSVQCDNSDKF--PVYKYPG--KGCP 281
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPV-----------DLRCASPSSLrgPLLELLHseFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-223 8.38e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 8.38e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  30 EVNCDKRNLTALPPDLPKDT--TILHLSENLLYTFSlATLMPYTRLTQLNLDRCELTKLQVD-GTLPVLGTLDLSHNQLQ 106
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPlGNLTNLEELDLSGNQLT 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 107 SLPLLGQTLPALTVLDVSFNRLTSLPlgALRGLGELQELYLKGNELKTLPPglLTPTPKLEKLSLANNNLTEL---PAGL 183
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLklkELEL 294

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 291190772 184 LNGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPW 223
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
34-234 1.36e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.62  E-value: 1.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  34 DKRNLTALPPDLPKDTTILHLSENLLYTFSLATLmpyTRLTQLNLDRCELTklqvdGTLPVLGTLDLSHNQLQSLPLLGQ 113
Cdd:COG4886   62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL---TNLTELDLSGNEEL-----SNLTNLESLDLSGNQLTDLPEELA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 114 TLPALTVLDVSFNRLTSLPLgALRGLGELQELYLKGNELKTLPPGLLtPTPKLEKLSLANNNLTELPAGlLNGLENLDTL 193
Cdd:COG4886  134 NLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEP-LGNLTNLEEL 210

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 291190772 194 LLQENSLYTIPKGFFGSHLLPFAFLHGN-----PWLCNC---EILYFRR 234
Cdd:COG4886  211 DLSGNQLTDLPEPLANLTNLETLDLSNNqltdlPELGNLtnlEELDLSN 259
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
34-205 4.91e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 78.97  E-value: 4.91e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  34 DKRNLTALPPDLPKDTTILHLSENLLYtfSLATLMPYTrLTQLNLDRCELTKLQvdGTLP-VLGTLDLSHNQLQSLPllg 112
Cdd:PRK15370 207 DNNELKSLPENLQGNIKTLYANSNQLT--SIPATLPDT-IQEMELSINRITELP--ERLPsALQSLDLFHNKISCLP--- 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 113 QTLP-ALTVLDVSFNRLTSLPLGALRGlgeLQELYLKGNELKTLPPGLltpTPKLEKLSLANNNLTELPAGLLNGLENLD 191
Cdd:PRK15370 279 ENLPeELRYLSVYDNSIRTLPAHLPSG---ITHLNVQSNSLTALPETL---PPGLKTLEAGENALTSLPASLPPELQVLD 352

                        170
                 ....*....|....
gi 291190772 192 tllLQENSLYTIPK 205
Cdd:PRK15370 353 ---VSKNQITVLPE 363
LRR_8 pfam13855
Leucine rich repeat;
116-176 3.67e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 3.67e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 291190772  116 PALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNL 176
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
35-208 8.20e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 65.10  E-value: 8.20e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  35 KRNLTALPPDLPKDTTILHLSENLLyTFSLATLMPytRLTQLNLDRCELTKLQvDGTLPVLGTLDLSHNQLQSLPllgQT 114
Cdd:PRK15370 292 DNSIRTLPAHLPSGITHLNVQSNSL-TALPETLPP--GLKTLEAGENALTSLP-ASLPPELQVLDVSKNQITVLP---ET 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 115 LP-ALTVLDVSFNRLTSLPLGALRGLGELQELYlkgNELKTLP---PGLLTPTPKLEKLSLANNNLTElpagllNGLENL 190
Cdd:PRK15370 365 LPpTITTLDVSRNALTNLPENLPAALQIMQASR---NNLVRLPeslPHFRGEGPQPTRIIVEYNPFSE------RTIQNM 435

                        170
                 ....*....|....*...
gi 291190772 191 DTLLLQENslYTIPKGFF 208
Cdd:PRK15370 436 QRLMSSVG--YQGPRVLF 451
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 27-174 4.15e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 4.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  27 SHLevNCDKRNLTALP-PDLPKDTTILHLSENLLYtfSLATLMPYTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHN-- 103
Cdd:cd21340    5 THL--YLNDKNITKIDnLSLCKNLKVLYLYDNKIT--KIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNri 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 104 ----------QLQSLPLLGQTLPA-----------------LTVLDVSFNRLTSlpLGALRGLGELQELYLKGNELKTLP 156
Cdd:cd21340   81 svveglenltNLEELHIENQRLPPgekltfdprslaalsnsLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLE 158

                        170       180
                 ....*....|....*....|
gi 291190772 157 P--GLLTPTPKLEKLSLANN 174
Cdd:cd21340  159 EllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
93-152 1.05e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.05e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 291190772   93 PVLGTLDLSHNQLQSL-PLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNEL 152
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 70-200 2.64e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.79  E-value: 2.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  70 YTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGqTLPALTVLDVSFNRLTSLPlgALRGLGELQELYLKG 149
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLE-FLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGG 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 291190772 150 NELKT-------------------LPPG---------LLTPTPKLEKLSLANNNLTELpaGLLNGLENLDTLLLQENSL 200
Cdd:cd21340   78 NRISVveglenltnleelhienqrLPPGekltfdprsLAALSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQI 154
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
31-207 6.33e-08

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 55.94  E-value: 6.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  31 VNCDKRNLTALPPDLPKDTTILHLSENLLYtfSLATLMPYTRltqlnldrceltklqvdgtlpvlgTLDLSHNQLQSLPL 110
Cdd:PRK15387 206 LNVGESGLTTLPDCLPAHITTLVIPDNNLT--SLPALPPELR------------------------TLEVSGNQLTSLPV 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 111 LGQTLPALTVLDVSFNRLTSLPLGalrglgeLQELYLKGNELKTLPpglLTPtPKLEKLSLANNNLTELPAgLLNGLENL 190
Cdd:PRK15387 260 LPPGLLELSIFSNPLTHLPALPSG-------LCKLWIFGNQLTSLP---VLP-PGLQELSVSDNQLASLPA-LPSELCKL 327

                        170
                 ....*....|....*..
gi 291190772 191 DTLLLQENSLYTIPKGF 207
Cdd:PRK15387 328 WAYNNQLTSLPTLPSGL 344
LRRNT smart00013
Leucine rich repeat N-terminal domain;
19-50 1.88e-07

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 47.31  E-value: 1.88e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 291190772    19 ICEVSKVASHLEVNCDKRNLTALPPDLPKDTT 50
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-224 2.68e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.40  E-value: 2.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  30 EVNCDKRNLTALPPDLPKDT--TILHLSENLLYTF-SLATLmpyTRLTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQ 106
Cdd:COG4886  209 ELDLSGNQLTDLPEPLANLTnlETLDLSNNQLTDLpELGNL---TNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLT 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 107 SLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNG 186
Cdd:COG4886  286 DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTL 365

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 291190772 187 LENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHGNPWL 224
Cdd:COG4886  366 LLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLL 403
LRR_8 pfam13855
Leucine rich repeat;
141-200 3.11e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.11e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  141 ELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSL 200
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 19-46 8.68e-07

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 45.31  E-value: 8.68e-07
                          10        20
                  ....*....|....*....|....*...
gi 291190772   19 ICEVSKVASHLEVNCDKRNLTALPPDLP 46
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
164-222 1.98e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.98e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  164 PKLEKLSLANNNLTELPAGLLNGLENLDTLLLQENSLYTI-PKGFFGSHLLPFAFLHGNP 222
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRRCT smart00082
Leucine rich repeat C-terminal domain;
221-281 2.90e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.73  E-value: 2.90e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 291190772   221 NPWLCNCEILYFRRWLQDnaeNVYVWKQGvdvkamtsnvaSVQCDNSDKF--PVYKYPG--KGCP 281
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPV-----------DLRCASPSSLrgPLLELLHseFKCP 51
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 51-200 3.13e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  51 ILHLSENLLYTFSLATL-----MPYTRLTQLNLDRCELTKL---QVDGTLPVLG---TLDLSHNQL--QSLPLLGQTLPA 117
Cdd:cd00116  112 ELKLNNNGLGDRGLRLLakglkDLPPALEKLVLGRNRLEGAsceALAKALRANRdlkELNLANNGIgdAGIRALAEGLKA 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 118 ---LTVLDVSFNRLTSLPLGAL----RGLGELQELYLKGNELK-----TLPPGLLTPTPKLEKLSLANNNLTELPAG-LL 184
Cdd:cd00116  192 ncnLEVLDLNNNGLTDEGASALaetlASLKSLEVLNLGDNNLTdagaaALASALLSPNISLLTLSLSCNDITDDGAKdLA 271

                        170
                 ....*....|....*....
gi 291190772 185 NGLENLDTLL---LQENSL 200
Cdd:cd00116  272 EVLAEKESLLeldLRGNKF 290
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 73-221 6.46e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 6.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  73 LTQLNLDRCELTKLQVDGTLPVLGTLDLSHNQLQ-SLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNE 151
Cdd:PLN00113 120 LRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQ 199

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 291190772 152 LKTLPPGLLTPTPKLEKLSLANNNLT-ELPA--GLLNGLENLDtlLLQENSLYTIPKGFFGSHLLPFAFLHGN 221
Cdd:PLN00113 200 LVGQIPRELGQMKSLKWIYLGYNNLSgEIPYeiGGLTSLNHLD--LVYNNLTGPIPSSLGNLKNLQYLFLYQN 270
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
74-204 1.65e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.69  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  74 TQLNLDRCELTKlqVDGTLP-VLGTLDLSHNQLQSLPllgQTLPaltvldvsfnrltslplgalrglGELQELYLKGNEL 152
Cdd:PRK15370 181 TELRLKILGLTT--IPACIPeQITTLILDNNELKSLP---ENLQ-----------------------GNIKTLYANSNQL 232

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 291190772 153 KTLPPGLltpTPKLEKLSLANNNLTELPAGLLNGLENLDtllLQENSLYTIP 204
Cdd:PRK15370 233 TSIPATL---PDTIQEMELSINRITELPERLPSALQSLD---LFHNKISCLP 278
LRR_8 pfam13855
Leucine rich repeat;
71-128 2.39e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.39e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 291190772   71 TRLTQLNLDRCELTKLQVD--GTLPVLGTLDLSHNQLQSL-PLLGQTLPALTVLDVSFNRL 128
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
98-204 5.12e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 41.29  E-value: 5.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772   98 LDLSHNQLQSLPLLGQTLPALTVLDVSFN---RLTSLPLgalrgLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANN 174
Cdd:pfam14580  24 LDLRGYKIPIIENLGATLDQFDTIDFSDNeirKLDGFPL-----LRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNN 98

                          90       100       110
                  ....*....|....*....|....*....|.
gi 291190772  175 NLTELPAGL-LNGLENLDTLLLQENSLYTIP 204
Cdd:pfam14580  99 NLQELGDLDpLASLKKLTFLSLLRNPVTNKP 129
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
37-222 6.27e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.84  E-value: 6.27e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  37 NLTALPPdLPKDTTILHLSENLLYtfSLATLMP--------YTRLTQLNLDRCELTKLQVDG----TLPVL--GTLDLS- 101
Cdd:PRK15387 233 NLTSLPA-LPPELRTLEVSGNQLT--SLPVLPPgllelsifSNPLTHLPALPSGLCKLWIFGnqltSLPVLppGLQELSv 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 102 ---------------------HNQLQSLPLLGQTLPALTVLDVSFNRLTSLP------------LGALRGLGE-LQELYL 147
Cdd:PRK15387 310 sdnqlaslpalpselcklwayNNQLTSLPTLPSGLQELSVSDNQLASLPTLPselyklwaynnrLTSLPALPSgLKELIV 389

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 291190772 148 KGNELKTLPpglLTPTpKLEKLSLANNNLTE---LPAGLLnglenldTLLLQENSLYTIPKGFFGSHLLPFAFLHGNP 222
Cdd:PRK15387 390 SGNRLTSLP---VLPS-ELKELMVSGNRLTSlpmLPSGLL-------SLSVYRNQLTRLPESLIHLSSETTVNLEGNP 456
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 95-205 6.82e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.91  E-value: 6.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  95 LGTLDLSHNQLQ-SLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLAN 173
Cdd:PLN00113 286 LISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLST 365

                         90       100       110
                 ....*....|....*....|....*....|....
gi 291190772 174 NNLT-ELPAGLLNGlENLDTLLLQENSLYT-IPK 205
Cdd:PLN00113 366 NNLTgEIPEGLCSS-GNLFKLILFSNSLEGeIPK 398
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 164-198 1.73e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.73e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 291190772  164 PKLEKLSLANNNLTELPagLLNGLENLDTLLLQEN 198
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGN 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-182 1.79e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  53 HLSENLLYTFSLATLMPYTRLTQLNLDRCELTKLQVDG-------TLPVLGTLDLSHNQLQ-----------SLPLLGQT 114
Cdd:PLN00113 381 NLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGelpseftKLPLVYFLDISNNNLQgrinsrkwdmpSLQMLSLA 460

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 115 -------LP------ALTVLDVSFNRLTSLPLGALRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLT-ELP 180
Cdd:PLN00113 461 rnkffggLPdsfgskRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIP 540


                 ..
gi 291190772 181 AG 182
Cdd:PLN00113 541 AS 542
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 95-128 3.01e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 3.01e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 291190772   95 LGTLDLSHNQLQSLPLLGQtLPALTVLDVSFNRL 128
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAK-LPNLETLDLSGNNK 35
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-129 4.57e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 4.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  52 LHLSENLLYTFSLATLMPYTRLTQLNLDRCELTklqvdGTLP-------VLGTLDLSHNQLQ-SLPLLGQTLPALTVLDV 123
Cdd:PLN00113 480 LDLSRNQFSGAVPRKLGSLSELMQLKLSENKLS-----GEIPdelssckKLVSLDLSHNQLSgQIPASFSEMPVLSQLDL 554


                 ....*.
gi 291190772 124 SFNRLT 129
Cdd:PLN00113 555 SQNQLS 560
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
38-200 4.72e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.15  E-value: 4.72e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772  38 LTALPpDLPKDTTILHLSENLLYtfSLATLMpyTRLTQLNLDRCELTKLQvdgTLPV-LGTLDLSHNQLQSLPLLGQTLP 116
Cdd:PRK15387 334 LTSLP-TLPSGLQELSVSDNQLA--SLPTLP--SELYKLWAYNNRLTSLP---ALPSgLKELIVSGNRLTSLPVLPSELK 405

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 291190772 117 ALTvldVSFNRLTSLPLgalrglgelqelylkgnelktLPPGLLTptpklekLSLANNNLTELPAGLLNgLENLDTLLLQ 196
Cdd:PRK15387 406 ELM---VSGNRLTSLPM---------------------LPSGLLS-------LSVYRNQLTRLPESLIH-LSSETTVNLE 453


                 ....
gi 291190772 197 ENSL 200
Cdd:PRK15387 454 GNPL 457
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 142-176 9.82e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 9.82e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 291190772  142 LQELYLKGNELKTLPPglLTPTPKLEKLSLANNNL 176
Cdd:pfam12799   3 LEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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