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Conserved domains on  [gi|194018488|ref|NP_000278|]
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peroxisome biogenesis factor 6 isoform 1 [Homo sapiens]

Protein Classification

CDC48 family AAA ATPase( domain architecture ID 1001098)

CDC48 family AAA ATPase is involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus; similar to yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CDC48 super family cl36852
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 466-977 2.61e-99

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


The actual alignment was detected with superfamily member TIGR01243:

Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 328.40  E-value: 2.61e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGL-GE- 543
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVtGEv 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  544 DARVMAVLRHLLlneDPLNSCPPLMVVATTSRAQDL-PADVQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLA 621
Cdd:TIGR01243 295 EKRVVAQLLTLM---DGLKGRGRVIVIGATNRPDALdPALRRPGrFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLD 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  622 QLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAgFPLLAEDFGQALEQLQTAHSQAVGApKIPS 701
Cdd:TIGR01243 372 KLAEVTHGFVGADLAALAKEAAMAALRRFIREGKINFEAEEIPAEVLKE-LKVTMKDFMEALKMVEPSAIREVLV-EVPN 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  702 VSWHDVGGLQEVKKEILETIQLPLEHPEL--LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVG 779
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIfeKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  780 QSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALL 859
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALL 608

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  860 RPGRFDKLVFVGAnEDRASQLRVLSAITRKFKLEPSVSLvNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHD-----LE 934
Cdd:TIGR01243 609 RPGRFDRLILVPP-PDEEARKEIFKIHTRSMPLAEDVDL-EELAEMTEGYTGADIEAVCREAAMAALRESIGSpakekLE 686

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 194018488  935 EGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977
Cdd:TIGR01243 687 VGEEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKEL 729
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 466-977 2.61e-99

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 328.40  E-value: 2.61e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGL-GE- 543
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVtGEv 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  544 DARVMAVLRHLLlneDPLNSCPPLMVVATTSRAQDL-PADVQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLA 621
Cdd:TIGR01243 295 EKRVVAQLLTLM---DGLKGRGRVIVIGATNRPDALdPALRRPGrFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLD 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  622 QLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAgFPLLAEDFGQALEQLQTAHSQAVGApKIPS 701
Cdd:TIGR01243 372 KLAEVTHGFVGADLAALAKEAAMAALRRFIREGKINFEAEEIPAEVLKE-LKVTMKDFMEALKMVEPSAIREVLV-EVPN 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  702 VSWHDVGGLQEVKKEILETIQLPLEHPEL--LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVG 779
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIfeKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  780 QSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALL 859
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALL 608

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  860 RPGRFDKLVFVGAnEDRASQLRVLSAITRKFKLEPSVSLvNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHD-----LE 934
Cdd:TIGR01243 609 RPGRFDRLILVPP-PDEEARKEIFKIHTRSMPLAEDVDL-EELAEMTEGYTGADIEAVCREAAMAALRESIGSpakekLE 686

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 194018488  935 EGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977
Cdd:TIGR01243 687 VGEEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKEL 729
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 696-964 3.11e-89

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 288.06  E-value: 3.11e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 696 APKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLL--HGPPGTGKTLLAKAVATECSLTFLSVKGPEL 773
Cdd:COG1222   69 PAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVllYGPPGTGKTLLAKAVAGELGAPFIRVRGSEL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 774 INMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVmDRVVSQLLAELDGLHSTQDVFVIGATNRPDL 853
Cdd:COG1222  149 VSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEV-QRTVNQLLAELDGFESRGDVLIIAATNRPDL 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 854 LDPALLRPGRFDKLVFVGaNEDRASQLRVLSAITRKFKLEPSV---SLVNVLDccppQLTGADLYSLCSDAMTAALKRRV 930
Cdd:COG1222  228 LDPALLRPGRFDRVIEVP-LPDEEAREEILKIHLRDMPLADDVdldKLAKLTE----GFSGADLKAIVTEAGMFAIREGR 302

                        250       260       270
                 ....*....|....*....|....*....|....
gi 194018488 931 HdleeglepgssalMLTMEDLLQAAARLQPSVSE 964
Cdd:COG1222  303 D-------------TVTMEDLEKAIEKVKKKTET 323
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 713-870 4.52e-86

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 273.23  E-value: 4.52e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 713 VKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFAR 791
Cdd:cd19527    1 VKKEILDTIQLPLEHPELfSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 792 ARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHST-QDVFVIGATNRPDLLDPALLRPGRFDKLVFV 870
Cdd:cd19527   81 ARDAKPCVIFFDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSSgQDVFVIGATNRPDLLDPALLRPGRFDKLLYL 160
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 700-954 3.16e-62

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 216.62  E-value: 3.16e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLG--LRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMY 777
Cdd:PRK03992 126 PNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVgiEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKF 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 778 VGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGgvmDRVVS----QLLAELDGLHSTQDVFVIGATNRPDL 853
Cdd:PRK03992 206 IGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSG---DREVQrtlmQLLAEMDGFDPRGNVKIIAATNRIDI 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 854 LDPALLRPGRFDKLVFVgANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCpPQLTGADLYSLCSDA-MTAALKRRVHd 932
Cdd:PRK03992 283 LDPAILRPGRFDRIIEV-PLPDEEGRLEILKIHTRKMNLADDVDLEELAELT-EGASGADLKAICTEAgMFAIRDDRTE- 359

                        250       260
                 ....*....|....*....|..
gi 194018488 933 leeglepgssalmLTMEDLLQA 954
Cdd:PRK03992 360 -------------VTMEDFLKA 368
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 743-871 8.41e-53

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 180.48  E-value: 8.41e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  743 HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSggVM 822
Cdd:pfam00004   4 YGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDS--ES 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 194018488  823 DRVVSQLLAELDGL-HSTQDVFVIGATNRPDLLDPALLrpGRFDKLVFVG 871
Cdd:pfam00004  82 RRVVNQLLTELDGFtSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 743-871 7.30e-17

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 78.57  E-value: 7.30e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488   743 HGPPGTGKTLLAKAVATECSLTFLSVK-----------------GPELINMYVGQSEENVREVFARARAAAPCIIFFDEL 805
Cdd:smart00382   8 VGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqlllIIVGGKKASGSGELRLRLALALARKLKPDVLILDEI 87

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194018488   806 DSLApsrgrsgDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPgRFDKLVFVG 871
Cdd:smart00382  88 TSLL-------DAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLL 145
cell_div_CdvC NF041006
cell division protein CdvC;
466-635 1.05e-10

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 64.76  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRC-----RPAVLLLTAVD-LLGRDRD 539
Cdd:NF041006 137 ILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAREKskeegKPAIIFIDEIDaLLGVYSS 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 540 GLGEDARVmavlRHLLLNE-DPL---NSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAHLPLG 615
Cdd:NF041006 217 EVGGEVRV----RNQFLKEmDGLqdkSENYHVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSKIKLE 292

                        170       180
                 ....*....|....*....|
gi 194018488 616 QEVNLAQLARRCAGFVVGDL 635
Cdd:NF041006 293 NDVDLDELAEMTEGYTASDI 312
 
Name Accession Description Interval E-value
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 466-977 2.61e-99

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 328.40  E-value: 2.61e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGL-GE- 543
Cdd:TIGR01243 215 VLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVtGEv 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  544 DARVMAVLRHLLlneDPLNSCPPLMVVATTSRAQDL-PADVQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLA 621
Cdd:TIGR01243 295 EKRVVAQLLTLM---DGLKGRGRVIVIGATNRPDALdPALRRPGrFDREIVIRVPDKRARKEILKVHTRNMPLAEDVDLD 371

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  622 QLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAgFPLLAEDFGQALEQLQTAHSQAVGApKIPS 701
Cdd:TIGR01243 372 KLAEVTHGFVGADLAALAKEAAMAALRRFIREGKINFEAEEIPAEVLKE-LKVTMKDFMEALKMVEPSAIREVLV-EVPN 449

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  702 VSWHDVGGLQEVKKEILETIQLPLEHPEL--LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVG 779
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIfeKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  780 QSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALL 859
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDT-SVTDRIVNQLLTEMDGIQELSNVVVIAATNRPDILDPALL 608

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  860 RPGRFDKLVFVGAnEDRASQLRVLSAITRKFKLEPSVSLvNVLDCCPPQLTGADLYSLCSDAMTAALKRRVHD-----LE 934
Cdd:TIGR01243 609 RPGRFDRLILVPP-PDEEARKEIFKIHTRSMPLAEDVDL-EELAEMTEGYTGADIEAVCREAAMAALRESIGSpakekLE 686

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 194018488  935 EGLEPGSSALMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977
Cdd:TIGR01243 687 VGEEEFLKDLKVEMRHFLEALKKVKPSVSKEDMLRYERLAKEL 729
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 696-964 3.11e-89

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 288.06  E-value: 3.11e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 696 APKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLL--HGPPGTGKTLLAKAVATECSLTFLSVKGPEL 773
Cdd:COG1222   69 PAESPDVTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVllYGPPGTGKTLLAKAVAGELGAPFIRVRGSEL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 774 INMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVmDRVVSQLLAELDGLHSTQDVFVIGATNRPDL 853
Cdd:COG1222  149 VSKYIGEGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEV-QRTVNQLLAELDGFESRGDVLIIAATNRPDL 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 854 LDPALLRPGRFDKLVFVGaNEDRASQLRVLSAITRKFKLEPSV---SLVNVLDccppQLTGADLYSLCSDAMTAALKRRV 930
Cdd:COG1222  228 LDPALLRPGRFDRVIEVP-LPDEEAREEILKIHLRDMPLADDVdldKLAKLTE----GFSGADLKAIVTEAGMFAIREGR 302

                        250       260       270
                 ....*....|....*....|....*....|....
gi 194018488 931 HdleeglepgssalMLTMEDLLQAAARLQPSVSE 964
Cdd:COG1222  303 D-------------TVTMEDLEKAIEKVKKKTET 323
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 713-870 4.52e-86

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 273.23  E-value: 4.52e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 713 VKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFAR 791
Cdd:cd19527    1 VKKEILDTIQLPLEHPELfSSGLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 792 ARAAAPCIIFFDELDSLAPSRGRSGDSGGVMDRVVSQLLAELDGLHST-QDVFVIGATNRPDLLDPALLRPGRFDKLVFV 870
Cdd:cd19527   81 ARDAKPCVIFFDELDSLAPSRGNSGDSGGVMDRVVSQLLAELDGMSSSgQDVFVIGATNRPDLLDPALLRPGRFDKLLYL 160
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 713-870 9.93e-76

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 245.27  E-value: 9.93e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 713 VKKEILETIQLPLEHPELLSLGLRRSGL--LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFA 790
Cdd:cd19511    1 VKRELKEAVEWPLKHPDAFKRLGIRPPKgvLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 791 RARAAAPCIIFFDELDSLAPSRGRSgDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFV 870
Cdd:cd19511   81 KARQAAPCIIFFDEIDSLAPRRGQS-DSSGVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLDKLIYV 159
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 713-870 1.96e-73

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 238.95  E-value: 1.96e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 713 VKKEILETIQLPLEHPELLSL--GLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFA 790
Cdd:cd19528    1 VKRELQELVQYPVEHPDKFLKfgMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 791 RARAAAPCIIFFDELDSLAPSRGRS-GDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVF 869
Cdd:cd19528   81 KARAAAPCVLFFDELDSIAKARGGNiGDAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLDQLIY 160


                 .
gi 194018488 870 V 870
Cdd:cd19528  161 I 161
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 539-957 3.31e-65

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 225.18  E-value: 3.31e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 539 DGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAHLPLGQEV 618
Cdd:COG0464    1 LAELLALAVALALALLLLDDAALRLLLLLLLALAAALLLLLLLLLLLLLALLLVELLLLLLSGALAALLLLALLLLALLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 619 NLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLLAEDFGQALEQLQTAHSQAvgapk 698
Cdd:COG0464   81 LLAALLSALELLLLGELLLLLLLLLLLLLLLLDLERALLELLRESAEALALAAPLVTYEDIGGLEEELLELREAI----- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 699 ipsvsWHDVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLLL--HGPPGTGKTLLAKAVATECSLTFLSVKGPELINM 776
Cdd:COG0464  156 -----LDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLllYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSK 230

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 777 YVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDsgGVMDRVVSQLLAELDGLHStqDVFVIGATNRPDLLDP 856
Cdd:COG0464  231 YVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGD--GVGRRVVNTLLTEMEELRS--DVVVIAATNRPDLLDP 306

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 857 ALLRpgRFDKLVFVGaNEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCpPQLTGADLYSLCSDAMTAALKRRvhdleeg 936
Cdd:COG0464  307 ALLR--RFDEIIFFP-LPDAEERLEIFRIHLRKRPLDEDVDLEELAEAT-EGLSGADIRNVVRRAALQALRLG------- 375

                        410       420
                 ....*....|....*....|.
gi 194018488 937 lepgssALMLTMEDLLQAAAR 957
Cdd:COG0464  376 ------REPVTTEDLLEALER 390
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 713-870 2.70e-64

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 213.90  E-value: 2.70e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 713 VKKEILETIQLPLEHPELLSLGLRRSGL--LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFA 790
Cdd:cd19529    1 VKQELKEAVEWPLLKPEVFKRLGIRPPKgiLLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 791 RARAAAPCIIFFDELDSLAPSRGRSGDSgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFV 870
Cdd:cd19529   81 KARQVAPCVIFFDEIDSIAPRRGTTGDS-GVTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFDRLIYI 159
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 713-869 2.62e-63

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 211.13  E-value: 2.62e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 713 VKKEILETIQLPLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFA 790
Cdd:cd19526    1 VKKALEETIEWPSKYPKifASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFS 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194018488 791 RARAAAPCIIFFDELDSLAPSRGRsgDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVF 869
Cdd:cd19526   81 RAQSAKPCILFFDEFDSIAPKRGH--DSTGVTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLDKLVY 157
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 700-954 3.16e-62

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 216.62  E-value: 3.16e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLG--LRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMY 777
Cdd:PRK03992 126 PNVTYEDIGGLEEQIREVREAVELPLKKPELFEEVgiEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKF 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 778 VGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGgvmDRVVS----QLLAELDGLHSTQDVFVIGATNRPDL 853
Cdd:PRK03992 206 IGEGARLVRELFELAREKAPSIIFIDEIDAIAAKRTDSGTSG---DREVQrtlmQLLAEMDGFDPRGNVKIIAATNRIDI 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 854 LDPALLRPGRFDKLVFVgANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCpPQLTGADLYSLCSDA-MTAALKRRVHd 932
Cdd:PRK03992 283 LDPAILRPGRFDRIIEV-PLPDEEGRLEILKIHTRKMNLADDVDLEELAELT-EGASGADLKAICTEAgMFAIRDDRTE- 359

                        250       260
                 ....*....|....*....|..
gi 194018488 933 leeglepgssalmLTMEDLLQA 954
Cdd:PRK03992 360 -------------VTMEDFLKA 368
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 710-870 5.20e-60

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 201.95  E-value: 5.20e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 710 LQEVKKEILETIQLPLEHPELLSLGLRRSGL--LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVRE 787
Cdd:cd19530    1 LDHVREELTMSILRPIKRPDIYKALGIDLPTgvLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 788 VFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVmdRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKL 867
Cdd:cd19530   81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASE--RVVNQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKT 158


                 ...
gi 194018488 868 VFV 870
Cdd:cd19530  159 LYV 161
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 706-868 1.08e-59

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 201.37  E-value: 1.08e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 706 DVGGLQEVKKEILETIQLPLEHPELLSLGLRRSG--LLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEE 783
Cdd:cd19503    1 DIGGLDEQIASLKELIELPLKYPELFRALGLKPPrgVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 784 NVREVFARARAAAPCIIFFDELDSLAPSRGRsgDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGR 863
Cdd:cd19503   81 NLREIFEEARSHAPSIIFIDEIDALAPKREE--DQREVERRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPGR 158


                 ....*
gi 194018488 864 FDKLV 868
Cdd:cd19503  159 FDREV 163
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 698-961 2.95e-59

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 217.08  E-value: 2.95e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  698 KIPSVSWHDVGGLQEVKKEILETIQLPLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELIN 775
Cdd:TIGR01243 171 KVPKVTYEDIGGLKEAKEKIREMVELPMKHPElfEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGAYFISINGPEIMS 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  776 MYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSgdSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLD 855
Cdd:TIGR01243 251 KYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEV--TGEVEKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALD 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  856 PALLRPGRFDKLVFVGANEDRASQlRVLSAITRKFKLEPSVSLVNVLDCCpPQLTGADLYSLCSDAMTAALKRRVHDLEE 935
Cdd:TIGR01243 329 PALRRPGRFDREIVIRVPDKRARK-EILKVHTRNMPLAEDVDLDKLAEVT-HGFVGADLAALAKEAAMAALRRFIREGKI 406

                         250       260       270
                  ....*....|....*....|....*....|..
gi 194018488  936 GLEPGS------SALMLTMEDLLQAAARLQPS 961
Cdd:TIGR01243 407 NFEAEEipaevlKELKVTMKDFMEALKMVEPS 438
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
 700-954 1.12e-58

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 205.80  E-value: 1.12e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  700 PSVSWHDVGGLQEVKKEILETIQLPLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMY 777
Cdd:TIGR01242 117 PNVSYEDIGGLEEQIREIREAVELPLKHPElfEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVRKY 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  778 VGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGG-VMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDP 856
Cdd:TIGR01242 197 IGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRTDSGTSGDrEVQRTLMQLLAELDGFDPRGNVKVIAATNRPDILDP 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  857 ALLRPGRFDKLVFVGANEDRAsQLRVLSAITRKFKLEPSVSL---VNVLDCCppqlTGADLYSLCSDAMTAALKRRvhdl 933
Cdd:TIGR01242 277 ALLRPGRFDRIIEVPLPDFEG-RLEILKIHTRKMKLAEDVDLeaiAKMTEGA----SGADLKAICTEAGMFAIREE---- 347

                         250       260
                  ....*....|....*....|.
gi 194018488  934 eeglepgssALMLTMEDLLQA 954
Cdd:TIGR01242 348 ---------RDYVTMDDFIKA 359
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 703-868 4.01e-56

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 191.40  E-value: 4.01e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 703 SWHDVGGLQEVKKEILETIQLPLEHPELLSLG--LRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQ 780
Cdd:cd19502    1 TYEDIGGLDEQIREIREVVELPLKHPELFEELgiEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 781 SEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGgvmDRVVS----QLLAELDGLHSTQDVFVIGATNRPDLLDP 856
Cdd:cd19502   81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFDSGTGG---DREVQrtmlELLNQLDGFDPRGNIKVIMATNRPDILDP 157

                        170
                 ....*....|..
gi 194018488 857 ALLRPGRFDKLV 868
Cdd:cd19502  158 ALLRPGRFDRKI 169
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 713-870 5.65e-54

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 184.79  E-value: 5.65e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 713 VKKEILETIQLPLEHPELLSLGLRRSGLLL-HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFAR 791
Cdd:cd19481    1 LKASLREAVEAPRRGSRLRRYGLGLPKGILlYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFER 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194018488 792 ARAAAPCIIFFDELDSLAPSRGRSGDSgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFV 870
Cdd:cd19481   81 ARRLAPCILFIDEIDAIGRKRDSSGES-GELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFDEVIEF 158
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 706-871 3.55e-53

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 183.02  E-value: 3.55e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 706 DVGGLQEVKKEILETIQLPLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEE 783
Cdd:cd19519    1 DIGGCRKQLAQIREMVELPLRHPElfKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESES 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 784 NVREVFARARAAAPCIIFFDELDSLAPSRGRSgdSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGR 863
Cdd:cd19519   81 NLRKAFEEAEKNAPAIIFIDEIDAIAPKREKT--HGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGR 158


                 ....*...
gi 194018488 864 FDKLVFVG 871
Cdd:cd19519  159 FDREIDIG 166
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 743-871 8.41e-53

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 180.48  E-value: 8.41e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  743 HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSggVM 822
Cdd:pfam00004   4 YGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDS--ES 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 194018488  823 DRVVSQLLAELDGL-HSTQDVFVIGATNRPDLLDPALLrpGRFDKLVFVG 871
Cdd:pfam00004  82 RRVVNQLLTELDGFtSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFP 129
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 700-938 6.30e-52

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 190.19  E-value: 6.30e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  700 PSVSWHDVGGLQEVKKEILETIQLpLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMY 777
Cdd:TIGR01241  50 PKVTFKDVAGIDEAKEELMEIVDF-LKNPSkfTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMF 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  778 VGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRsGDSGG--VMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLD 855
Cdd:TIGR01241 129 VGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGA-GLGGGndEREQTLNQLLVEMDGFGTNTGVIVIAATNRPDVLD 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  856 PALLRPGRFDKLVFVGaNEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCpPQLTGADLYSLCSDA-MTAALKRR----V 930
Cdd:TIGR01241 208 PALLRPGRFDRQVVVD-LPDIKGREEILKVHAKNKKLAPDVDLKAVARRT-PGFSGADLANLLNEAaLLAARKNKteitM 285


                  ....*...
gi 194018488  931 HDLEEGLE 938
Cdd:TIGR01241 286 NDIEEAID 293
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 702-870 9.33e-52

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 178.97  E-value: 9.33e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 702 VSWHDVGGLQEVKKEILETIQLpLEHPELLSLGLRRSG--LLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVG 779
Cdd:cd19501    1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPkgVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 780 QSEENVREVFARARAAAPCIIFFDELDSLAPSRGR-SGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL 858
Cdd:cd19501   80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGAgLGGGHDEREQTLNQLLVEMDGFESNTGVIVIAATNRPDVLDPAL 159

                        170
                 ....*....|..
gi 194018488 859 LRPGRFDKLVFV 870
Cdd:cd19501  160 LRPGRFDRQVYV 171
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 692-936 3.77e-48

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 176.88  E-value: 3.77e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 692 QAVGAPKIPSVSWHDVGGLQEVKKEILETIQLPLEHPELLSLGL--RRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVK 769
Cdd:PTZ00454 132 QLLQMSEKPDVTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGidPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVV 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 770 GPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSR--GRSGDSGGVmDRVVSQLLAELDGLHSTQDVFVIGA 847
Cdd:PTZ00454 212 GSEFVQKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfdAQTGADREV-QRILLELLNQMDGFDQTTNVKVIMA 290

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 848 TNRPDLLDPALLRPGRFD-KLVFvgANEDRASQLRVLSAITRKFKLEPSVSLVNVLDcCPPQLTGADLYSLCSDA-MTAA 925
Cdd:PTZ00454 291 TNRADTLDPALLRPGRLDrKIEF--PLPDRRQKRLIFQTITSKMNLSEEVDLEDFVS-RPEKISAADIAAICQEAgMQAV 367

                        250
                 ....*....|....*
gi 194018488 926 LKRRV----HDLEEG 936
Cdd:PTZ00454 368 RKNRYvilpKDFEKG 382
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 698-929 9.09e-48

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 176.89  E-value: 9.09e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 698 KIPSVSWHDVGGLQEVKKEILETIQLPLEHPEL--LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELIN 775
Cdd:PTZ00361 176 KAPLESYADIGGLEQQIQEIKEAVELPLTHPELydDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQ 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 776 MYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSgDSGGVMD--RVVSQLLAELDGLHSTQDVFVIGATNRPDL 853
Cdd:PTZ00361 256 KYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDA-TSGGEKEiqRTMLELLNQLDGFDSRGDVKVIMATNRIES 334

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 854 LDPALLRPGRFD-KLVFvgANEDRASQLRVLSAITRKFKLEPSVSL---VNVLDccppQLTGADLYSLCSDAMTAALKRR 929
Cdd:PTZ00361 335 LDPALIRPGRIDrKIEF--PNPDEKTKRRIFEIHTSKMTLAEDVDLeefIMAKD----ELSGADIKAICTEAGLLALRER 408
ftsH CHL00176
cell division protein; Validated
 702-929 8.45e-46

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 175.24  E-value: 8.45e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 702 VSWHDVGGLQEVKKEiLETIQLPLEHPELLSLGLRRSGL--LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVG 779
Cdd:CHL00176 180 ITFRDIAGIEEAKEE-FEEVVSFLKKPERFTAVGAKIPKgvLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 780 QSEENVREVFARARAAAPCIIFFDELDSLAPSRGrSGDSGGVMDR--VVSQLLAELDGLHSTQDVFVIGATNRPDLLDPA 857
Cdd:CHL00176 259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRG-AGIGGGNDEReqTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAA 337

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194018488 858 LLRPGRFDKLVFVGAnEDRASQLRVLSAITRKFKLEPSVSLVnVLDCCPPQLTGADLYSLCSDAMTAALKRR 929
Cdd:CHL00176 338 LLRPGRFDRQITVSL-PDREGRLDILKVHARNKKLSPDVSLE-LIARRTPGFSGADLANLLNEAAILTARRK 407
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
703-949 3.53e-44

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 170.60  E-value: 3.53e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 703 SWHDVGGLQEVKKEILETIQLpLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQ 780
Cdd:PRK10733 150 TFADVAGCDEAKEEVAELVEY-LREPSrfQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGV 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 781 SEENVREVFARARAAAPCIIFFDELDSLAPSRGrSGDSGGVMDR--VVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL 858
Cdd:PRK10733 229 GASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRG-AGLGGGHDEReqTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPAL 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 859 LRPGRFDKLVFVGANEDRASQlRVLSAITRKFKLEPSVSlVNVLDCCPPQLTGADLYSLCSDAMTAALK--RRVHDLEEg 936
Cdd:PRK10733 308 LRPGRFDRQVVVGLPDVRGRE-QILKVHMRRVPLAPDID-AAIIARGTPGFSGADLANLVNEAALFAARgnKRVVSMVE- 384

                        250
                 ....*....|...
gi 194018488 937 LEPGSSALMLTME 949
Cdd:PRK10733 385 FEKAKDKIMMGAE 397
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
744-938 3.84e-44

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 169.45  E-value: 3.84e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 744 GPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGdsGGVMD 823
Cdd:COG0465  182 GPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGAGL--GGGHD 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 824 ---RVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVGAnEDRASQLRVLSAITRKFKLEPSVSLvN 900
Cdd:COG0465  260 ereQTLNQLLVEMDGFEGNEGVIVIAATNRPDVLDPALLRPGRFDRQVVVDL-PDVKGREAILKVHARKKPLAPDVDL-E 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 194018488 901 VLDCCPPQLTGADLYSLCSDamtAAL------KRRV--HDLEEGLE 938
Cdd:COG0465  338 VIARRTPGFSGADLANLVNE---AALlaarrnKKAVtmEDFEEAID 380
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 706-866 8.61e-44

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 156.41  E-value: 8.61e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 706 DVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGL--LLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEE 783
Cdd:cd19518    1 DIGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRgvLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 784 NVREVFARARAAAPCIIFFDELDSLAPSrgRSGDSGGVMDRVVSQLLAELDGL----HSTQDVFVIGATNRPDLLDPALL 859
Cdd:cd19518   81 KIRELFDQAISNAPCIVFIDEIDAITPK--RESAQREMERRIVSQLLTCMDELnnekTAGGPVLVIGATNRPDSLDPALR 158


                 ....*..
gi 194018488 860 RPGRFDK 866
Cdd:cd19518  159 RAGRFDR 165
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
743-959 3.09e-43

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 157.74  E-value: 3.09e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 743 HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARaAAPCIIFFDELDSLAPSRGRSGDSGGvM 822
Cdd:COG1223   41 YGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETARNLRKLFDFAR-RAPCVIFFDEFDAIAKDRGDQNDVGE-V 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 823 DRVVSQLLAELDGLHStqDVFVIGATNRPDLLDPALLRpgRFD-KLVFVGANEDRASQLrvLSAITRKFKLEPSVSLVNV 901
Cdd:COG1223  119 KRVVNALLQELDGLPS--GSVVIAATNHPELLDSALWR--RFDeVIEFPLPDKEERKEI--LELNLKKFPLPFELDLKKL 192

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 194018488 902 LDCCPPqLTGADLyslcSDAMTAALKRRVhdlEEGLEpgssalMLTMEDLLQAAARLQ 959
Cdd:COG1223  193 AKKLEG-LSGADI----EKVLKTALKKAI---LEDRE------KVTKEDLEEALKQRK 236
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 707-870 2.82e-41

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 149.04  E-value: 2.82e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 707 VGGLQEVKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENV 785
Cdd:cd19509    1 IAGLDDAKEALKEAVILPSLRPDLfPGLRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 786 REVFARARAAAPCIIFFDELDSLAPSRGrSGDSGGVMdRVVSQLLAELDGL--HSTQDVFVIGATNRPDLLDPALLRpgR 863
Cdd:cd19509   81 RALFALARELQPSIIFIDEIDSLLSERG-SGEHEASR-RVKTEFLVQMDGVlnKPEDRVLVLGATNRPWELDEAFLR--R 156


                 ....*..
gi 194018488 864 FDKLVFV 870
Cdd:cd19509  157 FEKRIYI 163
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 706-866 2.75e-39

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 143.42  E-value: 2.75e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 706 DVGGLQEVKKEILETIQLPLEHPE--LLSLGLRRSGLLLHGPPGTGKTLLAKAVATECS-----LTFLSVKGPELINMYV 778
Cdd:cd19517    1 DIGGLSHYINQLKEMVFFPLLYPEvfAKFKITPPRGVLFHGPPGTGKTLMARALAAECSkggqkVSFFMRKGADCLSKWV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 779 GQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSggVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL 858
Cdd:cd19517   81 GEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQ--IHASIVSTLLALMDGLDNRGQVVVIGATNRPDALDPAL 158


                 ....*...
gi 194018488 859 LRPGRFDK 866
Cdd:cd19517  159 RRPGRFDR 166
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 743-865 4.92e-38

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 140.32  E-value: 4.92e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 743 HGPPGTGKTLLAKAVATecsltFLS------VKGPELINMYVGQSEENVREVFARARA--------AAPCIIFFDELDSL 808
Cdd:cd19504   41 YGPPGTGKTLMARQIGK-----MLNarepkiVNGPEILNKYVGESEANIRKLFADAEEeqrrlganSGLHIIIFDEIDAI 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 194018488 809 APSRGRSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFD 865
Cdd:cd19504  116 CKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRKDLIDEALLRPGRLE 172
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 438-584 1.98e-36

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 134.72  E-value: 1.98e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 438 LEALVSELCAVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSR 517
Cdd:cd19481    1 LKASLREAVEAPRRGSRLRRYGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFER 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194018488 518 ARRCRPAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPADVQ 584
Cdd:cd19481   81 ARRLAPCILFIDEIDAIGRKRDSSGESGELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALL 147
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 700-870 9.56e-36

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 133.45  E-value: 9.56e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYV 778
Cdd:cd19521    2 PNVKWEDVAGLEGAKEALKEAVILPVKFPHLfTGNRKPWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 779 GQSEENVREVFARARAAAPCIIFFDELDSLAPSRGrSGDSGGVMdRVVSQLLAELDGL-HSTQDVFVIGATNRPDLLDPA 857
Cdd:cd19521   82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRG-EGESEASR-RIKTELLVQMNGVgNDSQGVLVLGATNIPWQLDSA 159

                        170
                 ....*....|...
gi 194018488 858 LLRpgRFDKLVFV 870
Cdd:cd19521  160 IRR--RFEKRIYI 170
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 706-870 1.83e-33

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 127.02  E-value: 1.83e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 706 DVGGLQEVKKEILETIQLPLEHPELLSLGLRR-SGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEEN 784
Cdd:cd19522    1 DIADLEEAKKLLEEAVVLPMWMPEFFKGIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 785 VREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGVMdRVVSQLLAELDGLHSTQD-------VFVIGATNRPDLLDPA 857
Cdd:cd19522   81 VRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHEASR-RVKSELLVQMDGVGGASEnddpskmVMVLAATNFPWDIDEA 159

                        170
                 ....*....|...
gi 194018488 858 LLRpgRFDKLVFV 870
Cdd:cd19522  160 LRR--RLEKRIYI 170
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 700-870 8.91e-33

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 125.49  E-value: 8.91e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 700 PSVSWHDVGGLQEVKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYV 778
Cdd:cd19525   17 PPINWADIAGLEFAKKTIKEIVVWPMLRPDIfTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 779 GQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGvmDRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDP 856
Cdd:cd19525   97 GEGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESS--RRIKTEFLVQLDGATTSSEdrILVVGATNRPQEIDE 174

                        170
                 ....*....|....
gi 194018488 857 ALLRpgRFDKLVFV 870
Cdd:cd19525  175 AARR--RLVKRLYI 186
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 706-864 1.43e-32

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 124.07  E-value: 1.43e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 706 DVGGLQEVKKEILETIQLPLEHPELLSLGLRRSGLL---LHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSE 782
Cdd:cd19520    1 DIGGLDEVITELKELVILPLQRPELFDNSRLLQPPKgvlLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQ 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 783 ENVREVFARARAAAPCIIFFDELDSLAPSRgRSGDSgGVMDRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDPALLR 860
Cdd:cd19520   81 KLVAAVFSLASKLQPSIIFIDEIDSFLRQR-SSTDH-EATAMMKAEFMSLWDGLSTDGNcrVIVMGATNRPQDLDEAILR 158


                 ....*.
gi 194018488 861 --PGRF 864
Cdd:cd19520  159 rmPKRF 164
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 706-870 2.16e-32

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 123.42  E-value: 2.16e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 706 DVGGLQEVKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEEN 784
Cdd:cd19524    1 DIAGQDLAKQALQEMVILPSLRPELfTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 785 VREVFARARAAAPCIIFFDELDSLAPSRgRSGDSGGVMdRVVSQLLAELDGLHSTQD--VFVIGATNRPDLLDPALLRpg 862
Cdd:cd19524   81 VRALFAVARELQPSIIFIDEVDSLLSER-SEGEHEASR-RLKTEFLIEFDGVQSNGDdrVLVMGATNRPQELDDAVLR-- 156


                 ....*...
gi 194018488 863 RFDKLVFV 870
Cdd:cd19524  157 RFTKRVYV 164
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 743-871 2.78e-25

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 102.61  E-value: 2.78e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 743 HGPPGTGKTLLAKAVATEC---SLTFLSVKGPELINMYVGQSEEN---VREVFARARAAAPCIIFFDELDSLAPsrgrsg 816
Cdd:cd00009   25 YGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGhflVRLLFELAEKAKPGVLFIDEIDSLSR------ 98

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 194018488 817 dsgGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVG 871
Cdd:cd00009   99 ---GAQNALLRVLETLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIP 150
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 466-594 3.81e-25

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 101.52  E-value: 3.81e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLG--RDRDGLGE 543
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAgsRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 194018488  544 DARVMAVLRHLLlnEDPLNSCPPLMVVATTSRAQDLPADVQTAFPHELEVP 594
Cdd:pfam00004  81 SRRVVNQLLTEL--DGFTSSNSKVIVIAATNRPDKLDPALLGRFDRIIEFP 129
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 437-640 6.09e-24

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 103.93  E-value: 6.09e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 437 GLEALVSELC-AVLKPRLQPG-----GALLTGtsSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCaeSS--GAVE 508
Cdd:COG1222   82 GLDEQIEEIReAVELPLKNPElfrkyGIEPPK--GVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELV--SKyiGEGA 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 509 TKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGL---GEDARVMAVlrhlLLNE-DPLNSCPPLMVVATTSRAQDL-PADV 583
Cdd:COG1222  158 RNVREVFELAREKAPSIIFIDEIDAIAARRTDDgtsGEVQRTVNQ----LLAElDGFESRGDVLIIAATNRPDLLdPALL 233

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 194018488 584 QTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLT 640
Cdd:COG1222  234 RPGrFDRVIEVPLPDEEAREEILKIHLRDMPLADDVDLDKLAKLTEGFSGADLKAIVT 291
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 460-635 4.03e-23

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 103.07  E-value: 4.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 460 LTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRD 539
Cdd:COG0464  188 LPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRG 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 540 GLGEdaRVMAVLRHLLLNE-DplNSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAHLPLGQEV 618
Cdd:COG0464  268 EVGD--GVGRRVVNTLLTEmE--ELRSDVVVIAATNRPDLLDPALLRRFDEIIFFPLPDAEERLEIFRIHLRKRPLDEDV 343

                        170
                 ....*....|....*..
gi 194018488 619 NLAQLARRCAGFVVGDL 635
Cdd:COG0464  344 DLEELAEATEGLSGADI 360
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 744-870 4.61e-23

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 96.67  E-value: 4.61e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 744 GPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSgGVMD 823
Cdd:cd19507   38 GIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIEKGFSNADSKGDS-GTSS 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 194018488 824 RVVSQLLAELDglHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFV 870
Cdd:cd19507  117 RVLGTFLTWLQ--EKKKPVFVVATANNVQSLPPELLRKGRFDEIFFV 161
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
466-635 2.24e-20

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 91.48  E-value: 2.24e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRcRPAVLLLTAVDLLGRDRDGLGEDA 545
Cdd:COG1223   38 ILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETARNLRKLFDFARR-APCVIFFDEFDAIAKDRGDQNDVG 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 546 RVMAVLRHLLLNEDPLNScpPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAHLPLGQEVNLAQLAR 625
Cdd:COG1223  117 EVKRVVNALLQELDGLPS--GSVVIAATNHPELLDSALWRRFDEVIEFPLPDKEERKEILELNLKKFPLPFELDLKKLAK 194

                        170
                 ....*....|
gi 194018488 626 RCAGFVVGDL 635
Cdd:COG1223  195 KLEGLSGADI 204
ycf46 CHL00195
Ycf46; Provisional
 744-876 7.84e-19

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 90.85  E-value: 7.84e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 744 GPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSgGVMD 823
Cdd:CHL00195 266 GIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESESRMRQMIRIAEALSPCILWIDEIDKAFSNSESKGDS-GTTN 344

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 194018488 824 RVVSQLLAELDglHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVG--ANEDR 876
Cdd:CHL00195 345 RVLATFITWLS--EKKSPVFVVATANNIDLLPLEILRKGRFDEIFFLDlpSLEER 397
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 706-870 1.01e-17

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 81.47  E-value: 1.01e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 706 DVGGLQEVKKEILETIQLPLEHPEL-LSLGLRRSGLLLHGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYVGQSEEN 784
Cdd:cd19523    1 DIAGLGALKAAIKEEVLWPLLRPDAfSGLLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 785 VREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGGvmdRVVSQLLAELDG-LHSTQD-VFVIGATNRPDLLDPALLRpg 862
Cdd:cd19523   81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVG---RLQVELLAQLDGvLGSGEDgVLVVCTTSKPEEIDESLRR-- 155


                 ....*...
gi 194018488 863 RFDKLVFV 870
Cdd:cd19523  156 YFSKRLLV 163
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 743-871 7.30e-17

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 78.57  E-value: 7.30e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488   743 HGPPGTGKTLLAKAVATECSLTFLSVK-----------------GPELINMYVGQSEENVREVFARARAAAPCIIFFDEL 805
Cdd:smart00382   8 VGPPGSGKTTLARALARELGPPGGGVIyidgedileevldqlllIIVGGKKASGSGELRLRLALALARKLKPDVLILDEI 87

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194018488   806 DSLApsrgrsgDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPgRFDKLVFVG 871
Cdd:smart00382  88 TSLL-------DAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLL 145
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 437-591 4.16e-14

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 71.28  E-value: 4.16e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 437 GLEALVSELCA-VLKPRLQPGGALLTGT---SSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQ 512
Cdd:cd19518    4 GMDSTLKELCElLIHPILPPEYFQHLGVeppRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEKIR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 513 AIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA--RVMAvlrHLLLNEDPLNSCP----PLMVVATTSRAQDLPADVQTA 586
Cdd:cd19518   84 ELFDQAISNAPCIVFIDEIDAITPKRESAQREMerRIVS---QLLTCMDELNNEKtaggPVLVIGATNRPDSLDPALRRA 160


                 ....*..
gi 194018488 587 --FPHEL 591
Cdd:cd19518  161 grFDREI 167
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 466-581 4.32e-13

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 68.09  E-value: 4.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLG--RDRDGLGE 543
Cdd:cd19503   37 VLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKNLREIFEEARSHAPSIIFIDEIDALApkREEDQREV 116

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 194018488 544 DARVMAVLRHLLlneDPLNSCPPLMVVATTSRAQDL-PA 581
Cdd:cd19503  117 ERRVVAQLLTLM---DGMSSRGKVVVIAATNRPDAIdPA 152
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 743-870 9.65e-13

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 66.61  E-value: 9.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 743 HGPPGTGKTLLAKAVATECSLTFLsvkgpeLINMY-VGQSEENVREVFARARAAApcIIFFDELDSLAPSR---GRSGDS 818
Cdd:cd19510   29 YGPPGTGKSSFIAALAGELDYDIC------DLNLSeVVLTDDRLNHLLNTAPKQS--IILLEDIDAAFESRehnKKNPSA 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 194018488 819 GGVMDRV-VSQLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFV 870
Cdd:cd19510  101 YGGLSRVtFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 437-593 1.01e-12

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 67.06  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 437 GLEALVSEL-----CAVLKPRLQPGGALLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKL 511
Cdd:cd19520    4 GLDEVITELkelviLPLQRPELFDNSRLLQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQKLV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 512 QAIFSRARRCRPAVLLLTAVDLLGRDRDglGEDARVMAVLR-HLLLNEDPLNSCPP--LMVVATTSRAQDLPADVQTAFP 588
Cdd:cd19520   84 AAVFSLASKLQPSIIFIDEIDSFLRQRS--STDHEATAMMKaEFMSLWDGLSTDGNcrVIVMGATNRPQDLDEAILRRMP 161


                 ....*
gi 194018488 589 HELEV 593
Cdd:cd19520  162 KRFHI 166
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 466-575 6.33e-12

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 64.61  E-value: 6.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDR---DGLG 542
Cdd:cd19511   30 VLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKARQAAPCIIFFDEIDSLAPRRgqsDSSG 109

                         90       100       110
                 ....*....|....*....|....*....|....
gi 194018488 543 EDARVMAVlrhlLLNE-DPLNSCPPLMVVATTSR 575
Cdd:cd19511  110 VTDRVVSQ----LLTElDGIESLKGVVVIAATNR 139
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 448-579 3.61e-11

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 62.37  E-value: 3.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 448 VLKPRLQPGgaLLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLL 527
Cdd:cd19509   19 SLRPDLFPG--LRGPPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEKIVRALFALARELQPSIIF 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 194018488 528 LTAVDLLGRDRdGLGEDARVMAVLRHLLLNEDPLNSCPP--LMVVATTSRAQDL 579
Cdd:cd19509   97 IDEIDSLLSER-GSGEHEASRRVKTEFLVQMDGVLNKPEdrVLVLGATNRPWEL 149
cell_div_CdvC NF041006
cell division protein CdvC;
466-635 1.05e-10

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 64.76  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRC-----RPAVLLLTAVD-LLGRDRD 539
Cdd:NF041006 137 ILLYGPPGCGKTMLAAAVANEIDSEFIHVDAASIMSKWLGEAEKNVAKIFKKAREKskeegKPAIIFIDEIDaLLGVYSS 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 540 GLGEDARVmavlRHLLLNE-DPL---NSCPPLMVVATTSRAQDLPADVQTAFPHELEVPALSEGQRLSILRALTAHLPLG 615
Cdd:NF041006 217 EVGGEVRV----RNQFLKEmDGLqdkSENYHVYVIGATNKPWRLDEPFLRRFQKRIYIPLPDREQRLELLKYYTSKIKLE 292

                        170       180
                 ....*....|....*....|
gi 194018488 616 QEVNLAQLARRCAGFVVGDL 635
Cdd:NF041006 293 NDVDLDELAEMTEGYTASDI 312
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 464-575 1.08e-10

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 60.91  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 464 SSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLG--RDRDGL 541
Cdd:cd19526   28 SGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRAQSAKPCILFFDEFDSIApkRGHDST 107

                         90       100       110
                 ....*....|....*....|....*....|....
gi 194018488 542 GEDARvmaVLRHLLLNEDPLNSCPPLMVVATTSR 575
Cdd:cd19526  108 GVTDR---VVNQLLTQLDGVEGLDGVYVLAATSR 138
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
442-643 1.32e-10

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 65.44  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 442 VSELCAVLKP--RLQP-GGALLTGtssVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRA 518
Cdd:PRK10733 164 VAELVEYLREpsRFQKlGGKIPKG---VLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQA 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 519 RRCRPAVLLLTAVDLLGRDRD---GLGEDARvMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PADVQTA-FPHELEV 593
Cdd:PRK10733 241 KKAAPCIIFIDEIDAVGRQRGaglGGGHDER-EQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLdPALLRPGrFDRQVVV 319

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 194018488 594 PALSEGQRLSILRALTAHLPLGQEVNLAQLARRCAGFVVGDLYALLTHSS 643
Cdd:PRK10733 320 GLPDVRGREQILKVHMRRVPLAPDIDAAIIARGTPGFSGADLANLVNEAA 369
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 466-575 5.08e-10

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 59.04  E-value: 5.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGlGEDA 545
Cdd:cd19530   33 VLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQVFQRARASAPCVIFFDEVDALVPKRGD-GGSW 111

                         90       100       110
                 ....*....|....*....|....*....|
gi 194018488 546 RVMAVLRHLLLNEDPLNSCPPLMVVATTSR 575
Cdd:cd19530  112 ASERVVNQLLTEMDGLEERSNVFVIAATNR 141
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 448-579 6.89e-10

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 59.62  E-value: 6.89e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 448 VLKPRLQPGgaLLTGTSS----VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRP 523
Cdd:cd19525   38 VVWPMLRPD--IFTGLRGppkgILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFSVARCKQP 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194018488 524 AVLLLTAVD-LLGRDRDGLGEDARVMAVlrHLLLNEDPLNSCPP--LMVVATTSRAQDL 579
Cdd:cd19525  116 AVIFIDEIDsLLSQRGEGEHESSRRIKT--EFLVQLDGATTSSEdrILVVGATNRPQEI 172
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 460-581 9.51e-10

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 58.29  E-value: 9.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 460 LTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRD 539
Cdd:cd19528   24 MTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARAAAPCVLFFDELDSIAKARG 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 194018488 540 GLGEDARVMA--VLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PA 581
Cdd:cd19528  104 GNIGDAGGAAdrVINQILTEMDGMNTKKNVFIIGATNRPDIIdPA 148
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 743-858 3.18e-09

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 57.84  E-value: 3.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 743 HGPPGTGKTLLAKAVATECSL---------TFLSVKGPELINMYVGQSEENVREVFARARAAAP---CIIF--FDELDSL 808
Cdd:cd19508   58 HGPPGTGKTSLCKALAQKLSIrlssryrygQLIEINSHSLFSKWFSESGKLVTKMFQKIQELIDdkdALVFvlIDEVESL 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 194018488 809 APSRG--RSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATNRPDLLDPAL 858
Cdd:cd19508  138 AAARSasSSGTEPSDAIRVVNAVLTQIDRIKRYHNNVILLTSNLLEKIDVAF 189
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 448-593 4.55e-09

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 56.43  E-value: 4.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 448 VLKPRLQPGgaLLTGTSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLL 527
Cdd:cd19523   20 LLRPDAFSG--LLRLPRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKILQASFLAARCRQPSVLF 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194018488 528 LTAVDLLGRDRDglGEDARVMAVLRHLLLNEDPLNSCPP--LMVVATTSRAQDLPADVQTAFPHELEV 593
Cdd:cd19523   98 ISDLDALLSSQD--DEASPVGRLQVELLAQLDGVLGSGEdgVLVVCTTSKPEEIDESLRRYFSKRLLV 163
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 466-626 2.64e-08

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 57.08  E-value: 2.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDR-DG-LGE 543
Cdd:PTZ00454 182 VLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfDAqTGA 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 544 DARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PADVQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEVNLA 621
Cdd:PTZ00454 262 DREVQRILLELLNQMDGFDQTTNVKVIMATNRADTLdPALLRPGrLDRKIEFPLPDRRQKRLIFQTITSKMNLSEEVDLE 341


                 ....*
gi 194018488 622 QLARR 626
Cdd:PTZ00454 342 DFVSR 346
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 466-575 3.22e-08

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 54.04  E-value: 3.22e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA 545
Cdd:cd19529   30 ILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKARQVAPCVIFFDEIDSIAPRRGTTGDSG 109

                         90       100       110
                 ....*....|....*....|....*....|
gi 194018488 546 RVMAVLRHLLLNEDPLNSCPPLMVVATTSR 575
Cdd:cd19529  110 VTERVVNQLLTELDGLEEMNGVVVIAATNR 139
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 466-592 7.37e-08

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 53.06  E-value: 7.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA 545
Cdd:cd19522   36 VLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSEEHE 115

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 194018488 546 RVMAVLRHLLLNEDPL-------NSCPPLMVVATTsraqDLPADVQTAFPHELE 592
Cdd:cd19522  116 ASRRVKSELLVQMDGVggasendDPSKMVMVLAAT----NFPWDIDEALRRRLE 165
ftsH CHL00176
cell division protein; Validated
 466-639 1.27e-07

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 55.44  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRD---GLG 542
Cdd:CHL00176 219 VLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVGVGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRGagiGGG 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 543 EDARvMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDLPA--------DVQTAFphelEVPALSEgqRLSILRALTAHLPL 614
Cdd:CHL00176 299 NDER-EQTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAallrpgrfDRQITV----SLPDREG--RLDILKVHARNKKL 371

                        170       180
                 ....*....|....*....|....*
gi 194018488 615 GQEVNLAQLARRCAGFVVGDLYALL 639
Cdd:CHL00176 372 SPDVSLELIARRTPGFSGADLANLL 396
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 744-868 1.47e-07

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 51.99  E-value: 1.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 744 GPPGTGKTLLAKAVATECSLTFLSV--------------KGPELINMYVGQSEENVREVFARARAAAPCIIFFD---ELD 806
Cdd:cd19505   19 GSIETGRSYLIKSLAANSYVPLIRIslnkllynkpdfgnDDWIDGMLILKESLHRLNLQFELAKAMSPCIIWIPnihELN 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194018488 807 SLAPSRGRSGDSGGVMDRVVSqLLAELDGLHSTQDVFVIGATNRPDLLDPALLRPGRFDKLV 868
Cdd:cd19505   99 VNRSTQNLEEDPKLLLGLLLN-YLSRDFEKSSTRNILVIASTHIPQKVDPALIAPNRLDTCI 159
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 464-594 2.08e-07

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 51.38  E-value: 2.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 464 SSVLLRGPPGCGKTTV---VAAACSHLGLHLLKVPCSSLCA---ESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRD 537
Cdd:cd00009   20 KNLLLYGPPGTGKTTLaraIANELFRPGAPFLYLNASDLLEglvVAELFGHFLVRLLFELAEKAKPGVLFIDEIDSLSRG 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194018488 538 RDGlgedarvmAVLRHLLLNEDPLNSCPPLMVVATTSRA--QDLPADVQTAFPHELEVP 594
Cdd:cd00009  100 AQN--------ALLRVLETLNDLRIDRENVRVIGATNRPllGDLDRALYDRLDIRIVIP 150
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 464-575 4.04e-07

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 50.59  E-value: 4.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 464 SSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGE 543
Cdd:cd19527   27 SGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKARDAKPCVIFFDELDSLAPSRGNSGD 106

                         90       100       110
                 ....*....|....*....|....*....|....
gi 194018488 544 DARVM-AVLRHLLLNEDPLNSCPP-LMVVATTSR 575
Cdd:cd19527  107 SGGVMdRVVSQLLAELDGMSSSGQdVFVIGATNR 140
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 466-606 4.51e-07

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 50.77  E-value: 4.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  466 VLLRGPPGCGKTT-----VVAAACSHL---GLHLLKVPCSSL----------------CAESSGAVETKLQAIFSRARRc 521
Cdd:pfam05729   3 VILQGEAGSGKTTllqklALLWAQGKLpqgFDFVFFLPCRELsrsgnarsladllfsqWPEPAAPVSEVWAVILELPER- 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  522 rpAVLLLTAVDLLGRDRDGLGEDARVMAVLRHLLlnedPLNSCP--PLMVVATTSRAQDLPADVQTafPHELEVPALSEG 599
Cdd:pfam05729  82 --LLLILDGLDELVSDLGQLDGPCPVLTLLSSLL----RKKLLPgaSLLLTVRPDALRDLRRGLEE--PRYLEVRGFSES 153


                  ....*..
gi 194018488  600 QRLSILR 606
Cdd:pfam05729 154 DRKQYVR 160
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 744-853 7.56e-07

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 52.92  E-value: 7.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  744 GPPGTGKTLLAKAVATE-CSLTFLS------VKGPELINMYVGQSEENVREVFARARAAapcIIFFDELDSLAPSRGRSG 816
Cdd:TIGR03922 319 GPPGTGKTTIARVVAKIyCGLGVLRkplvreVSRADLIGQYIGESEAKTNEIIDSALGG---VLFLDEAYTLVETGYGQK 395

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 194018488  817 DSGGVMdrVVSQLLAELDglHSTQDVFVIGATNRPDL 853
Cdd:TIGR03922 396 DPFGLE--AIDTLLARME--NDRDRLVVIGAGYRKDL 428
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 448-579 1.50e-06

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 49.08  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 448 VLKPRLQPggALLTG----TSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRP 523
Cdd:cd19524   16 VILPSLRP--ELFTGlrapARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKLVRALFAVARELQP 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194018488 524 AVLLLTAVD-LLGRDRDGLGEDARVMAVlrHLLLNEDPLNSCPP--LMVVATTSRAQDL 579
Cdd:cd19524   94 SIIFIDEVDsLLSERSEGEHEASRRLKT--EFLIEFDGVQSNGDdrVLVMGATNRPQEL 150
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 466-581 1.85e-06

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 48.87  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLG--RDRDGLGE 543
Cdd:cd19502   40 VLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGEGARLVRELFEMAREKAPSIIFIDEIDAIGakRFDSGTGG 119

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 194018488 544 DARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PA 581
Cdd:cd19502  120 DREVQRTMLELLNQLDGFDPRGNIKVIMATNRPDILdPA 158
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 466-575 3.60e-06

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 48.20  E-value: 3.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGL-GE- 543
Cdd:cd19519   37 ILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDEIDAIAPKREKThGEv 116

                         90       100       110
                 ....*....|....*....|....*....|..
gi 194018488 544 DARVMAVLRHLLlneDPLNSCPPLMVVATTSR 575
Cdd:cd19519  117 ERRIVSQLLTLM---DGLKQRAHVIVMAATNR 145
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 464-640 6.60e-06

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 49.45  E-value: 6.60e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 464 SSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLC----AESSGAVetklQAIFSRARRCRPAVLLLTAVDLLG--RD 537
Cdd:PRK03992 166 KGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVqkfiGEGARLV----RELFELAREKAPSIIFIDEIDAIAakRT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 538 RDGLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PADVQTA-FPHELEVPALSEGQRLSILRALTAHLPLG 615
Cdd:PRK03992 242 DSGTSGDREVQRTLMQLLAEMDGFDPRGNVKIIAATNRIDILdPAILRPGrFDRIIEVPLPDEEGRLEILKIHTRKMNLA 321

                        170       180
                 ....*....|....*....|....*
gi 194018488 616 QEVNLAQLARRCAGFVVGDLYALLT 640
Cdd:PRK03992 322 DDVDLEELAELTEGASGADLKAICT 346
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 743-868 1.28e-05

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 45.98  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 743 HGPPGTGKTLLAKAVATECSLTFLSVKGPELINMYvGQSEENVREVFARARAAAP-CIIFFDELDSLAPSRGRSGDSGGV 821
Cdd:cd19512   28 YGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMG-REGVTAIHKVFDWANTSRRgLLLFVDEADAFLRKRSTEKISEDL 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 194018488 822 mdRVVSQLLAELDGLHSTQDVFVIgATNRPDLLDPALlrPGRFDKLV 868
Cdd:cd19512  107 --RAALNAFLYRTGEQSNKFMLVL-ASNQPEQFDWAI--NDRIDEMV 148
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 465-594 2.38e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 45.44  E-value: 2.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488   465 SVLLRGPPGCGKTTVVAAACSHLGLHLLKV-----------------PCSSLCAESSGAVETKLQAIFSRARRCRPAVLL 527
Cdd:smart00382   4 VILIVGPPGSGKTTLARALARELGPPGGGViyidgedileevldqllLIIVGGKKASGSGELRLRLALALARKLKPDVLI 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194018488   528 LTAVDLLgrdrdgLGEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PADVQTAFPHELEVP 594
Cdd:smart00382  84 LDEITSL------LDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLgPALLRRRFDRRIVLL 145
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 430-546 4.14e-05

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 45.24  E-value: 4.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 430 WSSLSppGLEALVSELC-AVLKPRLQPggALLTG----TSSVLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESS 504
Cdd:cd19521    6 WEDVA--GLEGAKEALKeAVILPVKFP--HLFTGnrkpWSGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 194018488 505 GAVETKLQAIFSRARRCRPAVLLLTAVD-LLGRDRDGLGEDAR 546
Cdd:cd19521   82 GESEKLVKQLFAMARENKPSIIFIDEVDsLCGTRGEGESEASR 124
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 459-579 9.21e-05

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 44.74  E-value: 9.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 459 LLTGTSSVLLRGPPGCGKTTVVAAACSHLGL---------HLLKVPCSSLCA----ESSGAVETKLQAIFSRARRCRPAV 525
Cdd:cd19508   48 LITWNRLVLLHGPPGTGKTSLCKALAQKLSIrlssryrygQLIEINSHSLFSkwfsESGKLVTKMFQKIQELIDDKDALV 127

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 194018488 526 -LLLTAVDLLGRDRDGL---GEDARVMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL 579
Cdd:cd19508  128 fVLIDEVESLAAARSASssgTEPSDAIRVVNAVLTQIDRIKRYHNNVILLTSNLLEKI 185
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 743-804 1.46e-04

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 45.43  E-value: 1.46e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194018488 743 HGPPGTGKTLLAKAVATECSLTF--LS-----VKgpelinmyvgqseeNVREVFARARAAA----PCIIFFDE 804
Cdd:COG2256   55 WGPPGTGKTTLARLIANATDAEFvaLSavtsgVK--------------DIREVIEEARERRaygrRTILFVDE 113
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 466-583 2.01e-04

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 42.74  E-value: 2.01e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDGLGEDA 545
Cdd:cd19507   34 LLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIEKGFSNADSKGDSG 113

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 194018488 546 RVMAVLRHLL--LNEDPlnscPPLMVVATTSRAQDLPADV 583
Cdd:cd19507  114 TSSRVLGTFLtwLQEKK----KPVFVVATANNVQSLPPEL 149
pup_AAA TIGR03689
proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some ...
 466-575 5.84e-04

proteasome ATPase; In the Actinobacteria, as shown for Mycobacterium tuberculosis, some proteins are modified by ligation between an epsilon-amino group of a lysine side chain and the C-terminal carboxylate of the ubiquitin-like protein Pup. This modification leads to protein degradation by the archaeal-like proteasome found in the Actinobacteria. Members of this protein family belong to the AAA family of ATPases and tend to be clustered with the genes for Pup, the Pup ligase PafA, and structural components of the proteasome. This protein forms hexameric rings with ATPase activity. [Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 200312 [Multi-domain]  Cd Length: 512  Bit Score: 43.54  E-value: 5.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  466 VLLRGPPGCGKTTV---VA-------AACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRC----RPAVLLLTAV 531
Cdd:TIGR03689 219 VLLYGPPGCGKTLIakaVAnslaariGAEGGGKSYFLNIKGPELLNKYVGETERQIRLIFQRAREKasegRPVIVFFDEM 298

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 194018488  532 DLLGRDR-DGLGEDARVMAVLRhlLLNE-DPLNSCPPLMVVATTSR 575
Cdd:TIGR03689 299 DSLFRTRgSGVSSDVETTVVPQ--LLAEiDGVESLDNVIVIGASNR 342
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 744-804 6.03e-04

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 43.53  E-value: 6.03e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194018488 744 GPPGTGKTLLAKAVATECSLTFLSVKGpelinmyVGQSEENVREVFARARAAA----PCIIFFDE 804
Cdd:PRK13342  43 GPPGTGKTTLARIIAGATDAPFEALSA-------VTSGVKDLREVIEEARQRRsagrRTILFIDE 100
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 466-581 7.76e-04

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 41.45  E-value: 7.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRD---GLG 542
Cdd:cd19501   40 VLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVGVGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRGaglGGG 119

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 194018488 543 EDARvMAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PA 581
Cdd:cd19501  120 HDER-EQTLNQLLVEMDGFESNTGVIVIAATNRPDVLdPA 158
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 466-623 8.64e-04

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 42.84  E-value: 8.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTVVAAACSHLGLHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDR-----DG 540
Cdd:PTZ00361 220 VILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRydatsGG 299

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 541 LGEDARVMAvlrHLLLNEDPLNSCPPLMVVATTSRAQDL-PADVQTA-FPHELEVPALSEGQRLSILRALTAHLPLGQEV 618
Cdd:PTZ00361 300 EKEIQRTML---ELLNQLDGFDSRGDVKVIMATNRIESLdPALIRPGrIDRKIEFPNPDEKTKRRIFEIHTSKMTLAEDV 376


                 ....*
gi 194018488 619 NLAQL 623
Cdd:PTZ00361 377 DLEEF 381
Vps4_C pfam09336
Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase ...
 918-977 9.31e-04

Vps4 C terminal oligomerization domain; This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerization.


Pssm-ID: 462762 [Multi-domain]  Cd Length: 61  Bit Score: 38.25  E-value: 9.31e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194018488  918 CSDAMTAALKRRVHDLEEG--LEPgssalMLTMEDLLQAAARLQPSVSEQELLRYKRIQRKF 977
Cdd:pfam09336   4 CSPGDPGAIEMTWMDIPSDklLEP-----PVTMKDFLKALKSSRPTVSKEDLEKYEEFTKEF 60
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 466-581 4.82e-03

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 39.03  E-value: 4.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488 466 VLLRGPPGCGKTTV---VAAACSHLG--LHLLKVPCSSLCAESSGAVETKLQAIFSRARRCRPAVLLLTAVDLLGRDRDG 540
Cdd:cd19517   37 VLFHGPPGTGKTLMaraLAAECSKGGqkVSFFMRKGADCLSKWVGEAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSS 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 194018488 541 LGEDARVmAVLRHLLLNEDPLNSCPPLMVVATTSRAQDL-PA 581
Cdd:cd19517  117 KQEQIHA-SIVSTLLALMDGLDNRGQVVVIGATNRPDALdPA 157
ycf2 CHL00206
Ycf2; Provisional
 838-946 5.23e-03

Ycf2; Provisional


Pssm-ID: 214396 [Multi-domain]  Cd Length: 2281  Bit Score: 41.05  E-value: 5.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  838 STQDVFVIGATNRPDLLDPALLRPGRFDKLV-FVGAN-EDRASQLRVLSAiTRKFKLEPSVSLVNVLDCCPPQLTGADLY 915
Cdd:CHL00206 1769 STRNILVIASTHIPQKVDPALIAPNKLNTCIkIRRLLiPQQRKHFFTLSY-TRGFHLEKKMFHTNGFGSITMGSNARDLV 1847

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 194018488  916 SL----------------CSDAMTAALKRRVHDLEEGLEPGSSALML 946
Cdd:CHL00206 1848 ALtnealsisitqkksiiDTNTIRSALHRQTWDLRSQVRSVQDHGIL 1894
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 744-864 5.85e-03

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.04  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018488  744 GPPGTGKTLLAKAVAtecslTFLSVKGPELINMYVGQSEENV---REVFARA---------RAAA-PCIIFFDELDSLAP 810
Cdd:pfam07728   6 GPPGTGKTELAERLA-----AALSNRPVFYVQLTRDTTEEDLfgrRNIDPGGaswvdgplvRAAReGEIAVLDEINRANP 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194018488  811 SrgrsgdsggVMDRVVSQL------LAELDGL--HSTQDVFVIGATNRPDL----LDPALLRpgRF 864
Cdd:pfam07728  81 D---------VLNSLLSLLderrllLPDGGELvkAAPDGFRLIATMNPLDRglneLSPALRS--RF 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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