NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4506797|ref|NP_000324|]
View 

ataxin-7 isoform a [Homo sapiens]

Protein Classification

SCA7 domain-containing protein( domain architecture ID 10550843)

SCA7 domain-containing protein similar to protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 333-394 2.14e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


:

Pssm-ID: 462422  Cd Length: 61  Bit Score: 105.38  E-value: 2.14e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4506797    333 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 394
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 403-488 1.99e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    403 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 482
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                  ....*.
gi 4506797    483 ATEPAS 488
Cdd:PHA03247 2772 PAAPAA 2777
 
Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 333-394 2.14e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 105.38  E-value: 2.14e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4506797    333 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 394
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 PHA03247
large tegument protein UL36; Provisional
 403-488 1.99e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    403 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 482
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                  ....*.
gi 4506797    483 ATEPAS 488
Cdd:PHA03247 2772 PAAPAA 2777
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 407-482 5.83e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    407 PPQPLRDPHPAPPrTSQEPHQN-----PHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPL 481
Cdd:pfam03154 201 PSAPSVPPQGSPA-TSQPPNQTqstaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPL-PQPSLHGQMPPM 278


                  .
gi 4506797    482 P 482
Cdd:pfam03154 279 P 279
 
Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 333-394 2.14e-27

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 105.38  E-value: 2.14e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4506797    333 NKRLSEREFDPDIHCGVIdLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKTR 394
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVI-LPNGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
PHA03247 PHA03247
large tegument protein UL36; Provisional
 403-488 1.99e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    403 DSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaskPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLP 482
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASP-----ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771


                  ....*.
gi 4506797    483 ATEPAS 488
Cdd:PHA03247 2772 PAAPAA 2777
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 407-482 5.83e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.60  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    407 PPQPLRDPHPAPPrTSQEPHQN-----PHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPL 481
Cdd:pfam03154 201 PSAPSVPPQGSPA-TSQPPNQTqstaaPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPL-PQPSLHGQMPPM 278


                  .
gi 4506797    482 P 482
Cdd:pfam03154 279 P 279
PHA03247 PHA03247
large tegument protein UL36; Provisional
 403-666 7.42e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 7.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    403 DSQQPPQPLR-DPHPAPPRTSQEPHQNPhgviPSESKPFVASK-------PKPHTPSLPR-PPGCPAqqGGSAPIDPPPV 473
Cdd:PHA03247 2547 DAGDPPPPLPpAAPPAAPDRSVPPPRPA----PRPSEPAVTSRarrpdapPQSARPRAPVdDRGDPR--GPAPPSPLPPD 2620

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    474 HESPHPPLPatEPASRLSSEEGEGDDKEESVEKLDCHYSGHHPQPASFCTFGSRQIGRGYYVFDSRWNRLRCALNLMVEk 553
Cdd:PHA03247 2621 THAPDPPPP--SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTS- 2697

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    554 hlnaqlWKKIPPVPSTTSPISTRIPHRTNSVPTSQCGVSYLAAATVSTSPVLLSSTCISPNSKSVPAHGTTLNAQPAASG 633
Cdd:PHA03247 2698 ------LADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP 2771

                         250       260       270
                  ....*....|....*....|....*....|...
gi 4506797    634 AMDPVCSMQSRQVSSSSSSPSTPSGLSSVPSSP 666
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPAVASLSESRESLPSPWDP 2804
PHA03247 PHA03247
large tegument protein UL36; Provisional
 402-486 3.28e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    402 PDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfvaSKPKPHTPSLPRPPGCPAQQGGSAPIdPPPVHESPHPPL 481
Cdd:PHA03247 2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPP---PQPQPPPPPPPRPQPPLAPTTDPAGA-GEPSGAVPQPWL 2964


                  ....*
gi 4506797    482 PATEP 486
Cdd:PHA03247 2965 GALVP 2969
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 397-487 4.85e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 39.84  E-value: 4.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797   397 ELIRHPDSQQPPQPlrDPHPAPPRTsQEPHQNPHGVIPSESKPFVASKPKPHT-PSLPRPPGCPAQQGGSAPIDPPPVHE 475
Cdd:PHA02682  71 ACMQRPSGQSPLAP--SPACAAPAP-ACPACAPAAPAPAVTCPAPAPACPPATaPTCPPPAVCPAPARPAPACPPSTRQC 147

                         90
                 ....*....|..
gi 4506797   476 SPHPPLPATEPA 487
Cdd:PHA02682 148 PPAPPLPTPKPA 159
PHA03247 PHA03247
large tegument protein UL36; Provisional
 400-491 5.92e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    400 RHPDSQQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPfVASKPKPHTPSLPRPPGCPAQQGGSAP-IDPPPVHESPH 478
Cdd:PHA03247 2865 RPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQ-PERPPQPQAPPPPQPQPQPPPPPQPQPpPPPPPRPQPPL 2943

                          90
                  ....*....|...
gi 4506797    479 PPLPATEPASRLS 491
Cdd:PHA03247 2944 APTTDPAGAGEPS 2956
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 405-489 6.65e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 6.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797   405 QQPPQPLRDPHPAPPRTSQEPHQNPHGVIPSESKPFVASKPKPHTPSLPRPPGCPAQQGGSAPIDPPPVHESPHPPLPAT 484
Cdd:PRK07764 616 AAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAG 695


                 ....*
gi 4506797   485 EPASR 489
Cdd:PRK07764 696 AAPAQ 700
PHA03247 PHA03247
large tegument protein UL36; Provisional
 407-491 7.76e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 7.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4506797    407 PPQPLRDPHPAPPRTSQEP-HQNPHGVIPSESKPFVASKPKPHTPSLPR-PPGCPAQQGGSAPIDPPPVHESPHPPLPAT 484
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPpAASPAGPLPPPTSAQPTAPPPPPGPPPPSlPLGGSVAPGGDVRRRPPSRSPAAKPAAPAR 2880


                  ....*..
gi 4506797    485 EPASRLS 491
Cdd:PHA03247 2881 PPVRRLA 2887
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH