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Conserved domains on  [gi|39812447|ref|NP_000339|]
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3-oxo-5-alpha-steroid 4-dehydrogenase 2 [Homo sapiens]

Protein Classification

3-oxo-5-alpha-steroid 4-dehydrogenase( domain architecture ID 10495092)

3-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)) converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
105-254 2.74e-74

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


:

Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 222.67  E-value: 2.74e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   105 RPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGG 184
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRGG 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   185 LFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 254
Cdd:pfam02544  81 LFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
 
Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
105-254 2.74e-74

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 222.67  E-value: 2.74e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   105 RPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGG 184
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRGG 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   185 LFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 254
Cdd:pfam02544  81 LFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
PLN02392 PLN02392
probable steroid reductase DET2
11-254 6.94e-39

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 136.09  E-value: 6.94e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   11 LAGSATLVALGALALyvakpsGYGKHTESlkPAATRLPARAAWFLQELPSFAV-----PAGILARQPLSLfgppgtVLLG 85
Cdd:PLN02392  18 LIGPPTFISLKFLQA------PYGKHNRL--GWGPTVSPPLAWFLMESPTLWLtlllfPLGQHFTNPKAL------LLMS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   86 LFCLHYFHRTFVYSL-------LNRGRPYPAILILRGTAFCTGNGVLQGYYLI-YCAEYPDGWYTDIRFSLGVFLFILGM 157
Cdd:PLN02392  84 PYLLHYFHRTCIYPLrlyrstsQQNTKGFPVSMALLAFGFNLLNAYLQARWVShYKDDYEDGGWFWWRFFGGLVVFLWGM 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447  158 GINIHSDYILRQLRKPGEiSYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLK 237
Cdd:PLN02392 164 RINVWSDRVLVGLKREGG-GYKVPRGGWFELVSCPNYFGEIVEWLGWAVMTWSWAGFGFFLYTCSNLVPRACANHKWYLE 242
                        250
                 ....*....|....*...
gi 39812447  238 MF-EDYPKSRKALIPFIF 254
Cdd:PLN02392 243 KFgEDYPKGRKAVIPFLY 260
 
Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
105-254 2.74e-74

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 222.67  E-value: 2.74e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   105 RPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGWYTDIRFSLGVFLFILGMGINIHSDYILRQLRKPGEISYRIPQGG 184
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRGG 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   185 LFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLKMFEDYPKSRKALIPFIF 254
Cdd:pfam02544  81 LFELVSCPNYFGEIMEWIGYALATWSLPALAFAFFTVCNLTPRAKAHHKWYLKKFEKYPKSRKALIPFVF 150
PLN02392 PLN02392
probable steroid reductase DET2
11-254 6.94e-39

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 136.09  E-value: 6.94e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   11 LAGSATLVALGALALyvakpsGYGKHTESlkPAATRLPARAAWFLQELPSFAV-----PAGILARQPLSLfgppgtVLLG 85
Cdd:PLN02392  18 LIGPPTFISLKFLQA------PYGKHNRL--GWGPTVSPPLAWFLMESPTLWLtlllfPLGQHFTNPKAL------LLMS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   86 LFCLHYFHRTFVYSL-------LNRGRPYPAILILRGTAFCTGNGVLQGYYLI-YCAEYPDGWYTDIRFSLGVFLFILGM 157
Cdd:PLN02392  84 PYLLHYFHRTCIYPLrlyrstsQQNTKGFPVSMALLAFGFNLLNAYLQARWVShYKDDYEDGGWFWWRFFGGLVVFLWGM 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447  158 GINIHSDYILRQLRKPGEiSYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRFYLK 237
Cdd:PLN02392 164 RINVWSDRVLVGLKREGG-GYKVPRGGWFELVSCPNYFGEIVEWLGWAVMTWSWAGFGFFLYTCSNLVPRACANHKWYLE 242
                        250
                 ....*....|....*...
gi 39812447  238 MF-EDYPKSRKALIPFIF 254
Cdd:PLN02392 243 KFgEDYPKGRKAVIPFLY 260
PLN02560 PLN02560
enoyl-CoA reductase
78-253 2.32e-13

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 68.21  E-value: 2.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447   78 PPGTVLLGLFCLHYFHRTFVYSLLNR--GRPYPAILILRGTAFCTGNGVLQGYYLIYCAEYPDGwytDIRFSLGVFLFIL 155
Cdd:PLN02560 127 PVQTYAMYYWCFHYAKRILETFFVHRfsHATSPLFNVFRNCAYYWTFGAYIAYFVNHPLYTPVS---ETQMKVGFGFGLV 203
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447  156 GMGINIHSDYILRQLRKP-GEISYRIPQGGLFTYVSGANFLGEIIEWIGYALATWSLPALAFAFFSLCFLGLRAFHHHRF 234
Cdd:PLN02560 204 CQLANFYCHIILRNLRKPdGKGGYQIPRGFLFNYVTCANYTTEIYQWLGFNIATQTVAGYLFLAVAAAIMTNWALAKHRR 283
                        170       180
                 ....*....|....*....|....*
gi 39812447  235 YLKMFE------DYPKSRKALIPFI 253
Cdd:PLN02560 284 LKKLFDgkdgrpKYPRRWVILPPFL 308
PLN03164 PLN03164
3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional
139-254 6.61e-11

3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal domain containing protein; Provisional


Pssm-ID: 215610 [Multi-domain]  Cd Length: 323  Bit Score: 61.37  E-value: 6.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 39812447  139 GWYTDIrfslGVFLFILGMGINIHSDYILRQLRKPGEIS--YRIPQGGLFTYVSGANFLGEIIEWIGYALAT-------W 209
Cdd:PLN03164 208 GWFQWI----GAAIFLWGWIHQYRCHAILGSLREHKKQAdeYVIPYGDWFEMVSCPHYLAEIVIYAGLLIASggtdltiW 283
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 39812447  210 SLpaLAFAFFSLCFlglRAFHHHRFYLKMFEDYPKSRKALIPFIF 254
Cdd:PLN03164 284 LL--FGFVVANLTF---AAAETHRWYLQKFENYPRNRYAIIPFVY 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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