|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02906 |
PLN02906 |
xanthine dehydrogenase |
23-1319 |
0e+00 |
|
xanthine dehydrogenase
Pssm-ID: 215491 [Multi-domain] Cd Length: 1319 Bit Score: 1723.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 23 ETTLLAYLRrKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQ 102
Cdd:PLN02906 1 HQTLLEYLR-DLGLTGTKLGCGEGGCGACTVMVSHYDRKTGKCVHYAVNACLAPLYSVEGMHVITVEGIGNRRDGLHPVQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 103 ERIAKSHGSQCGFCTPGIVMSMYTLLRNQPE-PTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNC-- 179
Cdd:PLN02906 80 EALASMHGSQCGFCTPGFIMSMYALLRSSKTpPTEEQIEECLAGNLCRCTGYRPILDAFRVFAKTDDALYTGVSSLSLqd 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 180 -----------CMNQKKDHSVSLSPSL--FKPEEFTPLD----PTQEPIFPPELLRLKDTPRKQLRFEGerVTWIQASTL 242
Cdd:PLN02906 160 gepicpstgkpCSCGSKTTSAAGTCKSdrFQPISYSEIDgswyTEKELIFPPELLLRKLTPLKLLGNGG--LTWYRPTSL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 243 KELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQ 322
Cdd:PLN02906 238 QHLLELKAEYPDAKLVVGNTEVGIEMRFKNAQYPVLISPTHVPELNAIKVKDDGLEIGAAVRLSELQNLFRKVVKERPAH 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 323 KTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSR-GTRRTVQMDHtFFPGYRKTLLSPE 401
Cdd:PLN02906 318 ETSACKAFIEQLKWFAGTQIRNVASIGGNICTASPISDLNPLWMAAGATFVIISCdGDIRSVPASD-FFLGYRKVDLKPD 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 402 EILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTE--VQELALCYGGMANRTISALKTTQRQLSKLWK 479
Cdd:PLN02906 397 EILLSVFLPWTRPFEYVKEFKQAHRRDDDIAIVNAGMRVKLEEKDGEwiVSDASIAYGGVAPLSVSARKTEEFLIGKPWN 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 480 EELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKL-GQENLEDKcgkLDPTFASATLLFQKDPPADV 558
Cdd:PLN02906 477 KETLQDALKVLQKDILIKEDAPGGMVEFRKSLALSFFFKFFLWVSHQLeADGSTIET---FPESHLSAAQPFPRPSSVGM 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 559 QLFQEVPKGQSeedmVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISA 638
Cdd:PLN02906 554 QDYETVKQGTA----VGQPEVHLSAELQVTGEAEYADDIPMPPNTLHAALVLSTKPHARILSIDDSEAKSSPGFAGIFLA 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 639 DDVPGSNITG-ICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFY-GPELKIE 716
Cdd:PLN02906 630 KDVPGDNMIGpVVHDEELFATDVVTCVGQVIGVVVADTQENAKAAARKVKVEYEELPAILSIEEAIEAGSFHpNTERRLE 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 717 KGDLKKGFS--EADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKR 794
Cdd:PLN02906 710 KGDVELCFAsgQCDRIIEGEVQMGGQEHFYLEPNSSLVWTSDSGNEVHMISSTQAPQKHQKYVAHVLGLPMSKVVCKTKR 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 795 MGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDL 874
Cdd:PLN02906 790 IGGGFGGKETRSAFIAAAAAVPAYLLNRPVKLTLDRDVDMMITGQRHAFLGKYKVGFTNEGKILALDLEIYNNGGNSLDL 869
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 875 SQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLT 954
Cdd:PLN02906 870 SGAVLERAMFHSDNVYEIPNVRIVGNVCFTNFPSNTAFRGFGGPQGMLITENWIQRIAVELNKSPEEIREMNFQGEGSVT 949
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 955 HFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTH 1034
Cdd:PLN02906 950 HYGQVLQHCTLPQLWDELKVSCDFLKRREEVDEFNAKNRWKKRGVAMVPTKFGISFTTKFMNQAGALVHVYTDGTVLVTH 1029
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1035 GGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPYKKKNPSGSW 1114
Cdd:PLN02906 1030 GGVEMGQGLHTKVAQVAASAFNIPLSSVFISETSTDKVPNASPTAASASSDMYGAAVLDACEQIKARMEPVASKLNFSSF 1109
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1115 EDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIG 1194
Cdd:PLN02906 1110 AELVTACYFQRIDLSAHGFYITPDIGFDWKTGKGNPFNYFTYGAAFAEVEIDTLTGDFHTRRVDIVMDLGYSINPAIDIG 1189
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1195 QVEGAFVQGLGLFTLEELHYS-------PEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAVGEPPLFL 1267
Cdd:PLN02906 1190 QIEGAFVQGLGWVALEELKWGdaahkwiRPGSLFTCGPGTYKIPSVNDIPFKFNVSLLKGAPNPKAIHSSKAVGEPPFFL 1269
|
1290 1300 1310 1320 1330
....*....|....*....|....*....|....*....|....*....|..
gi 91823271 1268 AASIFFAIKDAIRAARAQhtgNNVKELFRLDSPATPEKIRNACVDKFTTLCV 1319
Cdd:PLN02906 1270 AASVFFAIKDAIKAARAE---VGLHGWFPLDTPATPERIRMACGDEITAPFA 1318
|
|
| mam_aldehyde_ox |
TIGR02969 |
aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, ... |
5-1333 |
0e+00 |
|
aldehyde oxidase; Members of this family are mammalian aldehyde oxidase (EC 1.2.3.1) isozymes, closely related to xanthine dehydrogenase/oxidase.
Pssm-ID: 132014 [Multi-domain] Cd Length: 1330 Bit Score: 1507.22 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 5 KLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSLHHVA 84
Cdd:TIGR02969 2 ELLFYVNGRKVVEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPVNACLTPICSLYGAA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 85 VTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFA 164
Cdd:TIGR02969 82 VTTVEGIGSTRTRLHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPTLDQLTDALGGNLCRCTGYRPIIDACKTFC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 165 RDGGCCGGDGNNPnCCMNQKKDHSVSL------SPSLFKPEEFTPLDPTQEPIFPPELLRLKDT-PRKQLRFEGERVTWI 237
Cdd:TIGR02969 162 KTSGCCQSKENGV-CCLDQGINGLPEFeegdetSPELFSEEEFLPLDPTQELIFPPELMRMAEKqPQRTRVFYSERMMWI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 238 QASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVA 317
Cdd:TIGR02969 241 SPVTLKELLEAKFKYPQAPVVMGNTSVGPEVKFKGVFHPVIISPDRIEELSVVNHTGDGLTLGAGLSLAQVKDILADVVQ 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 318 KLPAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHTFFPGYRKTL 397
Cdd:TIGR02969 321 KLPEETTQTYRALLKHLGTLAGSQIRNMASLGGHIISRHLDSDLNPLLAVGNCTLNLLSKEGKRQIPLSEQFLSKCPDAD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 398 LSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTEVQELALCYGGMANRTISALKTTQRQLSKL 477
Cdd:TIGR02969 401 LKPQEILVSVNIPYSRKWEFVSAFRQAQRQQNALAIVNSGMRVFFGEGDGIIRELSISYGGVGPTTICAKNSCQKLIGRP 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 478 WKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTLSFFFKFYLTVLQKLGQEN------LEDKcgkldptFASATLLFQ 551
Cdd:TIGR02969 481 WNEEMLDTACRLILDEVSLAGSAPGGKVEFKRTLIISFLFKFYLEVSQILKRMDpghypsLADK-------YESALEDLH 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 552 KDPPADVQLFQEVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPG 631
Cdd:TIGR02969 554 SKHHWSTLKHQNVDSMQLPQDPIGHPIMHLSGVKHATGEAIYCDDMPAVDQELFLTFVTSSRAHAKIVSIDLSEALSLPG 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 632 FVCFISADDVPGSNITGIcndETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEEL-PAIITIEDAIKNNSFYG 710
Cdd:TIGR02969 634 VVDIITAEHLQDANTFGT---EKLLATDKVHCVGQLVCAVIADSEVQAKQAAKHVKIVYRDLePLILTIEEAIQHKSFFE 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 711 PELKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVV 790
Cdd:TIGR02969 711 PERKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMDVYVSTQFPKYIQDIVAATLKLPVNKVMC 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 791 RVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGN 870
Cdd:TIGR02969 791 HVRRVGGAFGGKVGKTSIMAAITAFAANKHGRAVRCTLERGEDMLITGGRHPYLGKYKAGFMNDGRIVALDVEHYSNGGS 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 871 TQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKE 950
Cdd:TIGR02969 871 SLDESLWVIEMGLLKMDNAYKFPNLRCRGWACRTNLPSNTAFRGFGFPQAGLITEACITEVAAKCGLSPEKVRTINMYKE 950
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 951 GDLTHFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSV 1030
Cdd:TIGR02969 951 IDQTPYKQEINAKNLFQCWRECMAKSSYSERKVAVEKFNAENYWKKRGLAVIPLKFPVGLGSVAMGQAAALVHIYLDGSV 1030
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1031 LLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPYKKKNP 1110
Cdd:TIGR02969 1031 LVTHGGIEMGQGVHTKMIQVVSRELKMPMSNVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQTLLKRLEPIISKNP 1110
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1111 SGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPA 1190
Cdd:TIGR02969 1111 QGTWKDWAQTAFDQSISLSAVGYFRGYESNINWEKGEGHPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGHSINPA 1190
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1191 IDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAVGEPPLFLAAS 1270
Cdd:TIGR02969 1191 LDIGQVEGAFIQGMGLYTIEELSYSPQGILYSRGPNQYKIPAICDIPTELHISFLPPSEHSNTLYSSKGLGESGVFLGCS 1270
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 91823271 1271 IFFAIKDAIRAARaQHTGnnVKELFRLDSPATPEKIRNACVDKFTTLCVTGVPENCKPWSVRV 1333
Cdd:TIGR02969 1271 VFFAIHDAVRAAR-QERG--LSGPWKLTSPLTPEKIRMACEDKFTKMIPRDEPGSYVPWNVPV 1330
|
|
| XdhB |
COG4631 |
Xanthine dehydrogenase, molybdopterin-binding subunit XdhB [Nucleotide transport and ... |
574-1310 |
0e+00 |
|
Xanthine dehydrogenase, molybdopterin-binding subunit XdhB [Nucleotide transport and metabolism];
Pssm-ID: 443669 [Multi-domain] Cd Length: 769 Bit Score: 1085.92 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 574 VGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSN-ITGICND 652
Cdd:COG4631 14 VGKSLPHESARLHVTGEARYIDDLPEPAGTLHAAPGLSPVAHARILSIDLSAVRAAPGVVAVLTAADIPGENdIGPIIHD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 653 ETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSFYGPELKIEKGDLKKGFSEADNVVS 732
Cdd:COG4631 94 EPLLADGEVEYVGQPVFAVVAESREAARRAARLAKIEYEELPAILTIEEALAAGSFVLPPHTLRRGDADAALAAAPHRLE 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 733 GEIYIGGQEHFYLETHCTIAVPkGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTA 812
Cdd:COG4631 174 GEFEIGGQEHFYLEGQIALAIP-GEDGGMLVHSSTQHPSEVQHLVAHVLGVPMHAVTVEVRRMGGGFGGKESQAALFAAL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 813 VALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKI 892
Cdd:COG4631 253 AALAARKTGRPVKLRLDRDDDMVMTGKRHPFRIDYEVGFDDDGRILGLDITLAARCGWSADLSGPVADRAMFHADNAYYL 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 893 PNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLY--KEGDLTHFNQKLEGFTLPRCWE 970
Cdd:COG4631 333 PAVRITGHRCKTNTQSNTAFRGFGGPQGMLAIERVIDDIARALGLDPLDVRRRNFYgpAERNTTPYGQPVEDNILHELVD 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 971 ECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQV 1050
Cdd:COG4631 413 ELEESSDYAARRAAIAAFNAASPVLKRGLALTPVKFGISFTATHLNQAGALVHVYTDGSVQLNHGGTEMGQGLHTKVAQV 492
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1051 ASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPY-------------------KKKNPS 1111
Cdd:COG4631 493 VADELGVPLERVRITATDTDKVPNTSATAASSGSDLNGMAAQDACRQIRERLAAFaaellgvepedvrfadgrvRVGGQS 572
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1112 GSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAI 1191
Cdd:COG4631 573 LSFAELVKAAYLARVSLSATGFYKTPKIHWDRATGQGRPFYYFAYGAAVSEVEIDTLTGEYRVLRVDILHDVGRSLNPAI 652
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1192 DIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAVGEPPLFLAASI 1271
Cdd:COG4631 653 DIGQIEGGFVQGMGWLTTEELVWDDKGRLLTHAPSTYKIPAASDRPEDFNVALLERPNREDTIYRSKAVGEPPLMLGISV 732
|
730 740 750
....*....|....*....|....*....|....*....
gi 91823271 1272 FFAIKDAIrAARAQHTGNnvkelFRLDSPATPEKIRNAC 1310
Cdd:COG4631 733 FEALRDAV-AAVGDYRVS-----PPLDAPATPERVLMAV 765
|
|
| xanthine_xdhB |
TIGR02965 |
xanthine dehydrogenase, molybdopterin binding subunit; Members of the protein family are the ... |
574-1310 |
0e+00 |
|
xanthine dehydrogenase, molybdopterin binding subunit; Members of the protein family are the molybdopterin-containing large subunit (or, in, eukaryotes, the molybdopterin-binding domain) of xanthine dehydrogenase, and enzyme that reduces the purine pool by catabolizing xanthine to urate. This model is based primarily on bacterial sequences; it does not manage to include all eukaryotic xanthine dehydrogenases and thereby discriminate them from the closely related enzyme aldehyde dehydrogenase. [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 274367 [Multi-domain] Cd Length: 758 Bit Score: 896.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 574 VGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSN-ITGICND 652
Cdd:TIGR02965 1 VGTSLKHESAHKHVAGTAVYIDDIPEPAGTLHAALGLSTRAHARITSMDLSAVRAAPGVVDVLTAADIPGENdISPIIHD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 653 ETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAI-KNNSFYGPELKIEKGDLKKGFSEADNVV 731
Cdd:TIGR02965 81 DPLLADGKVEFVGQPIFAVVATSRDAARRAARLAKIEYEELPAVLDIEEALaAGSRLVTPPLTLERGDAAAALAAAPHRL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 732 SGEIYIGGQEHFYLETHCTIAVPkGEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVST 811
Cdd:TIGR02965 161 SGTMRIGGQEHFYLEGQIALAVP-GEDGGMHVWSSTQHPSEVQHLVAHVLGVPSHAVTVEVRRMGGGFGGKETQANLFAC 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 812 AVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYK 891
Cdd:TIGR02965 240 LAAVAARKTGRPVKLRPDRDDDMMITGKRHDFRVDYDVGFDDEGRILGVDIDMAARCGFSADLSGPVTDRALFHADNAYF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 892 IPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGD--LTHFNQKLEGFTLPRCW 969
Cdd:TIGR02965 320 LPDVTITSHPLKTNTQSNTAFRGFGGPQGMVAIERIMDEVARALGKDPLEVRKRNFYGKDErnVTPYHQTVEDNIIHEII 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 970 EECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQ 1049
Cdd:TIGR02965 400 EELEASSDYAARRAAIRAFNATSPVLKKGIALTPVKFGISFTVTHLNQAGALVHVYTDGSIHLNHGGTEMGQGLNTKVAQ 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1050 VASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPYKKKNPSG----------------- 1112
Cdd:TIGR02965 480 VVAEEFQVDIDRVKITATDTGKVPNTSATAASSGSDLNGMAAQDAARQIKERLVEFAAEKWQVpeedvrfapnhvrvgeq 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1113 --SWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPA 1190
Cdd:TIGR02965 560 rvPFAELVQQAYFARVQLSSTGFYKTPKIHWDRAKGRGRPFYYFAYGAACSEVSVDTLTGEYKVLRADILHDVGRSLNPA 639
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1191 IDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKA-IYASKAVGEPPLFLAA 1269
Cdd:TIGR02965 640 IDIGQIEGGFVQGMGWLTTEELVWDEKGRLRTHAPSTYKIPAASDRPKDFNVRLFEWGENREDtIHRSKAVGEPPLMLGI 719
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 91823271 1270 SIFFAIKDAIrAARAQHTGNNvkelfRLDSPATPEKIRNAC 1310
Cdd:TIGR02965 720 SVLFAISDAV-ASVADYRVCP-----RLDAPATPERVLMAV 754
|
|
| PLN00192 |
PLN00192 |
aldehyde oxidase |
1-1310 |
0e+00 |
|
aldehyde oxidase
Pssm-ID: 215096 [Multi-domain] Cd Length: 1344 Bit Score: 765.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1 MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKIVHFSANACLAPICSL 80
Cdd:PLN00192 1 SSNMSLVFAVNGERFELSSVDPSTTLLEFLRTQTPFKSVKLGCGEGGCGACVVLLSKYDPVLDQVEDFTVSSCLTLLCSV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 81 HHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRN-----QPEP-------TMEEIENAFQGNLC 148
Cdd:PLN00192 81 NGCSITTSEGLGNSKDGFHPIHKRFAGFHASQCGFCTPGMCISLFSALVNadktdRPEPpsgfsklTVVEAEKAVSGNLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 149 RCTGYRPILQGFRTFARDGGCCGGDGnnpNCCMNQKKDHSVSLSpslfkpeEFTPLDPTQEPIFPPELLrlKDTPRKQLR 228
Cdd:PLN00192 161 RCTGYRPIVDACKSFAADVDIEDLGL---NSFWKKGESEEAKLS-------KLPPYNHSDHICTFPEFL--KKEIKSSLL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 229 FEGERVTWIQASTLKELLDL-KAQHPDA---KLVVGNTEIGIemkFKNM-LFPMIVCPAWIPELNSVEHGPDGISFGAAC 303
Cdd:PLN00192 229 LDSSRYRWYTPVSVEELQSLlESNNFDGvsvKLVVGNTGTGY---YKDEeLYDKYIDIRHIPELSMIRRDEKGIEIGAVV 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 304 PLSIVEKTLVDAvaklpAQKTEVFRGVLEQLRWFAGKQVKSVASVGGNIITAS----PiSDLNPVFMASGAKLTLVSRGT 379
Cdd:PLN00192 306 TISKAIEALREE-----SKSEYVFKKIADHMEKIASRFVRNTGSIGGNLVMAQrkqfP-SDIATILLAAGSTVNIQNASK 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 380 RRTVQMDHtFFpgyRKTLLSPEEILLSIEIPYSREGE------YFSAFKQASR-REDDIAKVTSGMRVLFK----PGTTE 448
Cdd:PLN00192 380 REKLTLEE-FL---ERPPLDSKSLLLSVEIPSWTSSSgsdtklLFETYRAAPRpLGNALPYLNAAFLAEVSqdasSGGIV 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 449 VQELALCYGGM-ANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELhlPPDAPGGMVDFRCTLTLSFFFKFyltvLQKL 527
Cdd:PLN00192 456 VNDCRLAFGAYgTKHAIRARKVEEFLTGKVLSDSVLYEAVRLLKGIV--VPEDGTSHPEYRSSLAVGFLFDF----LSPL 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 528 GQENLEDKCGKLDPTFASATLLFQKDPPADVQLF----QEVPKGQsEEDMVGRPLPHLAADMQASGEAVYCDDIPRYENE 603
Cdd:PLN00192 530 IESNAKSSNGWLDGGSNTKQNPDQHDDVKKPTLLlsskQQVEENN-EYHPVGEPIKKVGAALQASGEAVYVDDIPSPKNC 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 604 LSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVP--GSNI--TGICNDETVFAKDKVTCVGHIIGAVVADTPEHT 679
Cdd:PLN00192 609 LYGAFIYSTKPLARVKGIKFKSNLVPQGVLAVITFKDIPkgGQNIgsKTIFGPEPLFADEVTRCAGQRIALVVADTQKHA 688
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 680 QRAAQGVKITY--EEL-PAIITIEDAIKNNSFYG--PELKIEK-GDLKKGFSEADN-VVSGEIYIGGQEHFYLETHCTIA 752
Cdd:PLN00192 689 DMAANLAVVEYdtENLePPILTVEDAVKRSSLFEvpPFLYPKPvGDISKGMAEADHkILSAEIKLGSQYYFYMETQTALA 768
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 753 VPKgEAGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRPVRCMLDRDE 832
Cdd:PLN00192 769 LPD-EDNCIVVYSSTQCPEYVHSVIARCLGIPEHNVRVITRRVGGGFGGKAVKSMPVATACALAAFKLQRPVRMYLNRKT 847
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 833 DMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSqSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAF 912
Cdd:PLN00192 848 DMIMAGGRHPMKITYSVGFKSDGKITALHLDILINAGISPDIS-PIMPRNIIGALKKYDWGALSFDIKVCKTNLSSRSAM 926
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 913 RGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKLEG----FTLPRCWEECLASSQYHARKSEVDKF 988
Cdd:PLN00192 927 RAPGEVQGSYIAEAIIEHVASTLSMDVDSVRKINLHTYESLKLFYGDSAGepseYTLPSIWDKLASSSEFKQRTEMVKEF 1006
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 989 NKENCWKKRGLCIIPtkfgISFTVpFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRAL---KIPTS----- 1060
Cdd:PLN00192 1007 NRSNKWKKRGISRVP----IVHEV-MLRPTPGKVSILSDGSIAVEVGGIEIGQGLWTKVKQMAAFGLgmiKCDGGedlld 1081
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1061 KIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPYKK----KNPSGSWEDWVTAAYMDTVSLSATGFYrT 1136
Cdd:PLN00192 1082 KIRVIQSDTLSMIQGGFTAGSTTSESSCEAVRLCCVILVERLKPIKErlqeQMGSVTWDMLISQAYMQSVNLSASSYY-T 1160
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1137 PNLgysfetnsgNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSP 1216
Cdd:PLN00192 1161 PDP---------SSMEYLNYGAAVSEVEVDLLTGETTILRSDIIYDCGQSLNPAVDLGQIEGAFVQGIGFFMLEEYTTNS 1231
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1217 EGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAVGEPPLFLAASIFFAIKDAIRAARAQH---TGNNVKE 1293
Cdd:PLN00192 1232 DGLVVTDGTWTYKIPTVDTIPKQFNVEILNSGHHKKRVLSSKASGEPPLLLAASVHCATRAAIREARKQLlswGGIDGSD 1311
|
1370
....*....|....*...
gi 91823271 1294 L-FRLDSPATPEKIRNAC 1310
Cdd:PLN00192 1312 StFQLPVPATMPVVKELC 1329
|
|
| xanthine_xdhA |
TIGR02963 |
xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit ... |
6-523 |
3.03e-172 |
|
xanthine dehydrogenase, small subunit; Members of this protein family are the small subunit (or, in eukaryotes, the N-terminal domain) of xanthine dehydrogenase, an enzyme of purine catabolism via urate. The small subunit contains both an FAD and a 2Fe-2S cofactor. Aldehyde oxidase (retinal oxidase) appears to have arisen as a neofunctionalization among xanthine dehydrogenases in eukaryotes and [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 274365 [Multi-domain] Cd Length: 467 Bit Score: 520.29 E-value: 3.03e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 6 LVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQnKIVHFSANACLAPICSLHHVAV 85
Cdd:TIGR02963 1 IRFFLNGETVTLSDVDPTRTLLDYLREDAGLTGTKEGCAEGDCGACTVVVGELVDGG-KLRYRSVNACIQFLPSLDGKAV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 86 TTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRtfar 165
Cdd:TIGR02963 80 VTVEDLRQPDGRLHPVQQAMVECHGSQCGFCTPGFVMSLYALYKNSPAPSRADIEDALQGNLCRCTGYRPILDAAE---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 166 dggccggdgnnpnccmnQKKDHSVSlspslfkpeefTPLDPTQEPIFpPELLRLKDTPRKQLRFEGERVtwIQASTLKEL 245
Cdd:TIGR02963 156 -----------------AAFDYPCS-----------DPLDADRAPII-ERLRALRAGETVELNFGGERF--IAPTTLDDL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 246 LDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPaqkte 325
Cdd:TIGR02963 205 AALKAAHPDARIVAGSTDVGLWVTKQMRDLPDVIYVGQVAELKRIEETDDGIEIGAAVTLTDAYAALAKRYPELG----- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 326 vfrgvlEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDhTFFPGYRKTLLSPEEILL 405
Cdd:TIGR02963 280 ------ELLRRFASLQIRNAGTLGGNIANGSPIGDSPPALIALGARLTLRKGEGRRTLPLE-DFFIDYGKTDRQPGEFVE 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 406 SIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTteVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQD 485
Cdd:TIGR02963 353 ALHVPRPTPGERFRAYKISKRFDDDISAVCAAFNLELDGGV--VAEIRIAFGGMAATPKRAAATEAALLGKPWNEATVEA 430
|
490 500 510
....*....|....*....|....*....|....*....
gi 91823271 486 VCAGLAEELH-LPPDAPGGmvDFRCTLTLSFFFKFYLTV 523
Cdd:TIGR02963 431 AMAALAGDFTpLSDMRASA--EYRLLTAKNLLRRFFLET 467
|
|
| CoxL |
COG1529 |
Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit [Energy production and conversion]; ... |
574-1309 |
6.65e-170 |
|
Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit [Energy production and conversion]; Aldehyde, CO or xanthine dehydrogenase, Mo-binding subunit is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 441138 [Multi-domain] Cd Length: 741 Bit Score: 524.41 E-value: 6.65e-170
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 574 VGRPLPHLAADMQASGEAVYCDDIpRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGIC--N 651
Cdd:COG1529 10 IGKPVPRVDGPAKVTGRARYTDDI-RLPGMLYAAVVRSPHAHARIKSIDTSAALALPGVVAVLTGEDLPGLKFGLPGpdP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 652 DETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIK-----------NNSFYgpELKIEKGDL 720
Cdd:COG1529 89 DQPPLADDKVRYVGEPVAAVVAETREAARDAAELIKVEYEPLPAVVDPEAALApgaplvheelpGNVAA--EWRGERGDV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 721 KKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEaGEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFG 800
Cdd:COG1529 167 DAAFAEADVVVEATYTTPRLAHAPMEPRAAVAEWDGD-GRLTVWASTQGPHLVRRALARALGLPPEKVRVIAPDVGGGFG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 801 GKETrSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIME 880
Cdd:COG1529 246 GKLD-VYPEEVLAALAARKLGRPVKLVLTREEDFLADTHRHATVQRVRLGADKDGKITALRHDVVADTGAYASFGEAVLP 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 881 RALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDLTHFNQKL 960
Cdd:COG1529 325 LGATMATGPYAIPNVRVEARAVYTNTPPTGAYRGPGRPQAAFALESAMDELAEELGMDPVELRLRNLIRPGDFPPTGQPY 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 961 EGFTLPRCWEECLASSQYHARKSEVDKFNKEncwKKRGLciiptkfGISFTV----PFLNQAGALLHVYTDGSVLLTHGG 1036
Cdd:COG1529 405 DSGRLAECLEKAAEAFGWGERRARPAEARAG---KLRGI-------GVAAYIegsgGGGDPESARVRLNPDGSVTVYTGA 474
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1037 TEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPY----------- 1105
Cdd:COG1529 475 TDIGQGHETVLAQIAAEELGVPPEDVRVVLGDTDLTPYGGGTGGSRSTAVGGSAVRKAAEKLREKLLELaahllgadped 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1106 --------KKKNPSGSWEDWVTAAYMdtVSLSATGFYRTPnlgysfetnsgnPFHYFSYGVACSEVEIDCLTGDHKNLRT 1177
Cdd:COG1529 555 lefedgrvRVPGRSVSLAELAAAAYY--GGLEATGTYDPP------------TYPTYSFGAHVAEVEVDPETGEVRVLRV 620
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1178 DIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPiEFRVSLLrDCPNKKAIYAS 1257
Cdd:COG1529 621 VAVHDCGRVINPLLVEGQVEGGVVQGIGQALYEELVYDEDGQLLNANFADYLVPRAADVP-EIEVIFV-ETPDPTNPLGA 698
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|..
gi 91823271 1258 KAVGEPPLFLAASiffAIKDAIRAAraqhTGNNVKELfrldsPATPEKIRNA 1309
Cdd:COG1529 699 KGVGEPGTIGVAP---AIANAVYDA----TGVRIRDL-----PITPEKVLAA 738
|
|
| MoCoBD_1 |
pfam02738 |
Molybdopterin cofactor-binding domain; |
700-947 |
1.84e-122 |
|
Molybdopterin cofactor-binding domain;
Pssm-ID: 460671 [Multi-domain] Cd Length: 244 Bit Score: 379.49 E-value: 1.84e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 700 EDAIKNNSFygpelKIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEAGEMELFVSTQNTMKTQSFVAK 779
Cdd:pfam02738 3 EEPPNNVAF-----HREKGDVEAAFAEADHVVEGEYRTGRQEHFYMETRAALAVPDDEDGRLTVYSSTQGPHLVRRLVAR 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 780 MLGVPANRIVVRVKRMGGGFGGKeTRSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVA 859
Cdd:pfam02738 78 VLGIPENKVRVIVPRVGGGFGGK-TQSYPEEALAALAARKTGRPVKWVLDREEDMLATGHRHPFLIKYKVGADKDGKILA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 860 LEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPA 939
Cdd:pfam02738 157 LDVDLYADGGAYADLSPAVPERALSHLDGPYKIPNVRVDGRAVYTNTPPNGAFRGFGRPQGMFALERLMDELAEELGMDP 236
|
....*...
gi 91823271 940 EEVRRKNL 947
Cdd:pfam02738 237 LELRRRNL 244
|
|
| MoCoBD_2 |
pfam20256 |
Molybdopterin cofactor-binding domain; |
971-1237 |
4.07e-118 |
|
Molybdopterin cofactor-binding domain;
Pssm-ID: 466407 [Multi-domain] Cd Length: 282 Bit Score: 369.56 E-value: 4.07e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 971 ECLASSQYHARKSEVDKFNKENcwKKRGLCIIPTKFGISFTVPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQV 1050
Cdd:pfam20256 1 KALELSDYDERRAEQAEFNRGN--RKRGIGIAPYVEGSGLGPGALNQAGALVRLNPDGSVTVYTGGTEMGQGLETKLAQI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1051 ASRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLEPY---------------------KKKN 1109
Cdd:pfam20256 79 AAEALGIPPEDVRVVEGDTDTVPNGGGTGASRSTDVGGNAVLLAAEKLRERLLKIaahlleaspedlefedgkvyvKGDP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1110 PSGSWEDWVTAAYMDTVSLSATGFYRTPNlgysFETNSGNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNP 1189
Cdd:pfam20256 159 RSVTFAELAAAAYGEGVGLSATGFYTPPD----DETGQGPPFAYYPYGAHAAEVEVDPETGEVRVLRYVAVHDCGRVINP 234
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 91823271 1190 AIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIP 1237
Cdd:pfam20256 235 AIVEGQIEGGFVQGIGLALMEELVYDEDGQLLTASLMDYKIPTAADIP 282
|
|
| XdhA |
COG4630 |
Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and ... |
8-493 |
2.59e-111 |
|
Xanthine dehydrogenase, Fe-S cluster and FAD-binding subunit XdhA [Nucleotide transport and metabolism];
Pssm-ID: 443668 [Multi-domain] Cd Length: 476 Bit Score: 358.68 E-value: 2.59e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 8 FFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKlgcgeggcgacTVMLSkydRLQNKIVHFSA-NACLAPICSLHHVAVT 86
Cdd:COG4630 3 FLLNGELVELSDVPPTTTLLDWLREDRGLTGTKegcaegdcgacTVVVG---ELDDGGLRYRAvNACILFLPQLDGKALV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 87 TVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGfrtfARd 166
Cdd:COG4630 80 TVEGLAGPDGALHPVQQAMVDHHGSQCGFCTPGFVMSLFALYERGPAPDRADIEDALSGNLCRCTGYRPIIDA----AR- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 167 ggccggdgnnpnccmnqkkdhsvslspSLFKPEEFTPLDPTQEPIfPPELLRLKDTPRKQLRFEGERvtWIQASTLKELL 246
Cdd:COG4630 155 ---------------------------AMAEAPAPDPFAADRAAV-AAALRALADGETVELGAGGSR--FLAPATLDELA 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 247 DLKAQHPDAKLVVGNTEIGIEMKfKNM-LFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPaqkte 325
Cdd:COG4630 205 ALLAAHPDARLVAGATDVGLWVT-KQLrDLPPVIFLGRVAELRRIEETDDGLEIGAAVTLSDAEAALAAHFPELA----- 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 326 vfrgvlEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHtFFPGYRKTLLSPEEILL 405
Cdd:COG4630 279 ------ELLRRFASRQIRNAGTLGGNIANGSPIGDSPPALIALGAELVLRSGDGRRTLPLED-FFLGYRKTDLQPGEFVE 351
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 406 SIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTteVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQD 485
Cdd:COG4630 352 AIRIPLPAAGQRLRAYKVSKRFDDDISAVCAAFALTLDDGT--VTEARIAFGGMAATPKRARAAEAALLGQPWTEATVAA 429
|
....*...
gi 91823271 486 VCAGLAEE 493
Cdd:COG4630 430 AAAALAQD 437
|
|
| PRK09970 |
PRK09970 |
xanthine dehydrogenase subunit XdhA; Provisional |
572-1306 |
4.90e-86 |
|
xanthine dehydrogenase subunit XdhA; Provisional
Pssm-ID: 236637 [Multi-domain] Cd Length: 759 Bit Score: 297.76 E-value: 4.90e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 572 DMVGRPLPHLAADMQASGEAVYCDDIPRyENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVP-------GS 644
Cdd:PRK09970 1 MAIGKSIMRVDAIAKVTGRAKYTDDYVM-AGMLYAKYVRSPIAHGKVKSIDTEEARSLPGVEAVFTWEDVPdipfptaGH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 645 NITgicNDET-------VFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDAIKNNSfygPEL---- 713
Cdd:PRK09970 80 PWS---LDPNhrdiadrALLTRHVRHHGDAVAAVVARDELTAEKALKLIKVEYEELPVITDPEAALAEGA---PPIhngr 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 714 -------KIEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVpKGEAGEMELFVSTQNTMKTQSFVAKMLGVPAN 786
Cdd:PRK09970 154 gnllkqsTMSTGNVQQTIKAADYQVQGHYETPIVQHCHMENVTSYAY-MEDDGRITIVSSTQIPHIVRRVVGQALGIPWG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 787 RIVVRVKRMGGGFGGKETrSTVVSTAVALAAYKTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFS 866
Cdd:PRK09970 233 KVRVIKPYVGGGFGNKQD-VLEEPLAAFLTSKVGGRPVKVSLSREECFLATRTRHAFTIDIKMGVNRDGTLKGYSLDVLS 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 867 NVGNTQDLSQSIMERALFHMDNCYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKN 946
Cdd:PRK09970 312 NTGAYASHGHSIASAGGNKVAYLYPRCAYKYSSKTVYTNLPSAGAMRGYGAPQVVFAVESMLDDAATALGIDPVEFRLRN 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 947 LYKEGDLTHFNQK-LEGFTLPRCWEECLASSQYHARKSEVDkfnKENCWKKRGLCIIPTKFGiSFTVPF-LNQAGALLHV 1024
Cdd:PRK09970 392 AAREGDANPLSGKrIYSAGLPECLEKGRKIFEWDKRRAECK---NQQGNLRRGVGVACFSYT-SGTWPVgLEIAGARLLM 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1025 YTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIY-ISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRLE 1103
Cdd:PRK09970 468 NQDGTVQVQSGATEIGQGSDTVFSQMVAETVGIPVSDVRvISTQDTDVTPFDPGAYASRQSYVAGPAIRKAALELKEKIL 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1104 PYKKKN---PSGSW---EDWVTAAYMDTVSLS----ATGFYRTPNLGYSFETNSGNPFHY--FSYGVACSEVEIDCLTGD 1171
Cdd:PRK09970 548 AHAAVMlhqSAMNLdiiDGHIVVKRPGEPLMSleelAMDAYYHPERGGQITAESSIKTTTnpPAFGCTFVDVEVDIALCK 627
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1172 HKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPE-GS------LHTRGPSTYKIPAFGSIPIEfrvsl 1244
Cdd:PRK09970 628 VTINRILNVHDSGHILNPLLAEGQVHGGMGMGIGWALFEEMIIDEKtGVvrnpnlLDYKLPTMMDLPQLESAFVE----- 702
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 91823271 1245 lrdCPNKKAIYASKAVGEPPLFLAASiffAIKDAIRAAraqhTGNNVKELfrldsPATPEKI 1306
Cdd:PRK09970 703 ---IYEPQSAYGHKSLGEPPIISPAP---AIRNAVLMA----TGVAINTL-----PMTPQRL 749
|
|
| FAD_binding_5 |
pfam00941 |
FAD binding domain in molybdopterin dehydrogenase; |
233-412 |
1.21e-59 |
|
FAD binding domain in molybdopterin dehydrogenase;
Pssm-ID: 460007 [Multi-domain] Cd Length: 170 Bit Score: 202.00 E-value: 1.21e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 233 RVTWIQASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLS-IVEKT 311
Cdd:pfam00941 2 KFGYYRPASLAEALELLAAGPDAKLVAGGTSLGPLMKLRLARPDHLIDINGIPELRGIEETDGGLEIGAAVTLSeIAEPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 312 LVDAVAKLPaqktevfrgvlEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHtFFP 391
Cdd:pfam00941 82 LREAYPALS-----------EALRKIASPQIRNVGTIGGNIANASPISDLPPALLALDAKVELRSGEGERTVPLED-FFL 149
|
170 180
....*....|....*....|.
gi 91823271 392 GYRKTLLSPEEILLSIEIPYS 412
Cdd:pfam00941 150 GYGKTALEPGELITAVIIPLP 170
|
|
| PRK09800 |
PRK09800 |
putative hypoxanthine oxidase; Provisional |
552-1309 |
5.35e-56 |
|
putative hypoxanthine oxidase; Provisional
Pssm-ID: 182084 [Multi-domain] Cd Length: 956 Bit Score: 212.00 E-value: 5.35e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 552 KDPPADVQLfqeVPKGQSEEDMVGRPLPHLAADMQASGEAVYCDD-IPryENELSLRLVTSTRAHAKIKSIDTSEAKKVP 630
Cdd:PRK09800 153 NNPQATIDI---APTFRDDLEVIGKHYPKTDAAKMVQAKPCYVEDrVT--ADACVIKMLRSPHAHALITHLDVSKAEALP 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 631 GFVCFISADDVPGSNITGICN--------DETVFAKdKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEELPAIITIEDA 702
Cdd:PRK09800 228 GVVHVITHLNCPDIYYTPGGQsapepsplDRRMFGK-KMRHVGDRVAAVVAESEEIALEALKLIDVEYEVLKPVMSIDEA 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 703 IKNNS--------FYG------------------------------PELKIEK------GDLKKGFSEADNVVSGEIYIG 738
Cdd:PRK09800 307 MAEDApvvhdepvVYVagapdtleddnshaaqrgehmiinfpigsrPRKNIAAsihghiGDMDKGFADADVIIERTYNST 386
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 739 GQEHFYLETHCTIAVPKGEagEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKEtrSTVVSTAVALAAY 818
Cdd:PRK09800 387 QAQQCPTETHICFTRMDGD--RLVIHASTQVPWHLRRQVARLVGMKQHKVHVIKERVGGGFGSKQ--DILLEEVCAWATC 462
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 819 KTGRPVRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDNCYKIPNIRGT 898
Cdd:PRK09800 463 VTGRPVLFRYTREEEFIANTSRHVAKVTVKLGAKKDGRLTAVKMDFRANTGPYGNHSLTVPCNGPALSLPLYPCDNVDFQ 542
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 899 GRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGD----LTHFNQKLEGFTLPRCWEECLA 974
Cdd:PRK09800 543 VTTYYSNICPNGAYQGYGAPKGNFAITMALAELAEQLQIDQLEIIERNRVHEGQelkiLGAIGEGKAPTSVPSAASCALE 622
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 975 SSQYHARKS-EVDKFNKENC-WK-KRGLCIIPTKFGIsftvPFLNQAGALLHVYTDGSVLLTHGGTEMGQGLHTKMVQVA 1051
Cdd:PRK09800 623 EILRQGREMiQWSSPKPQNGdWHiGRGVAIIMQKSGI----PDIDQANCMIKLESDGTFIVHSGGADIGTGLDTVVTKLA 698
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1052 SRALKIPTSKIYISETSTNTVPNTSPTAASVSADLNGQAVYAACQTILKRL---------EP-----------YKKKNPS 1111
Cdd:PRK09800 699 AEVLHCPPQDVHVISGDTDHALFDKGAYASSGTCFSGNAARLAAENLREKIlfhgaqmlgEPvadvqlatpgvVRGKKGE 778
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1112 GSWEDWVTAAYMDT--VSLSATGFYRTPNLGysfetnsgnpfhyFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNP 1189
Cdd:PRK09800 779 VSFGDIAHKGETGTgfGSLVGTGSYITPDFA-------------FPYGANFAEVAVNTRTGEIRLDKFYALLDCGTPVNP 845
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 1190 AIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLrdcPNKKAI--YASKAVGEPPLFL 1267
Cdd:PRK09800 846 ELALGQIYGATLRAIGHSMSEEIIYDAEGHPLTRDLRSYGAPKIGDIPRDFRAVLV---PSDDKVgpFGAKSISEIGVNG 922
|
810 820 830 840
....*....|....*....|....*....|....*....|...
gi 91823271 1268 AA-SIFFAIKDAIraaraqhtgnnvkELFRLDSPATPEKIRNA 1309
Cdd:PRK09800 923 AApAIATAIHDAC-------------GIWLREWHFTPEKILTA 952
|
|
| Ald_Xan_dh_C |
pfam01315 |
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; |
588-694 |
1.34e-44 |
|
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain;
Pssm-ID: 426197 [Multi-domain] Cd Length: 107 Bit Score: 156.62 E-value: 1.34e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 588 SGEAVYCDDIPRYENELsLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITGICND-ETVFAKDKVTCVGH 666
Cdd:pfam01315 1 TGEAVYVDDIPAPGNLY-GAFVRSTIAHAKIVSIDTSAALALPGVVAVITAKDLPGGNYNIGPIPlDPLFATDKVRHVGQ 79
|
90 100
....*....|....*....|....*...
gi 91823271 667 IIGAVVADTPEHTQRAAQGVKITYEELP 694
Cdd:pfam01315 80 PIAAVVADDEETARRAAKLVKVEYEELP 107
|
|
| Ald_Xan_dh_C |
smart01008 |
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Aldehyde oxidase catalyses ... |
588-694 |
1.79e-41 |
|
Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Aldehyde oxidase catalyses the conversion of an aldehyde in the presence of oxygen and water to an acid and hydrogen peroxide. The enzyme is a homodimer, and requires FAD, molybdenum and two 2FE-2S clusters as cofactors. Xanthine dehydrogenase catalyses the hydrogenation of xanthine to urate, and also requires FAD, molybdenum and two 2FE-2S clusters as cofactors. This activity is often found in a bifunctional enzyme with xanthine oxidase activity too. The enzyme can be converted from the dehydrogenase form to the oxidase form irreversibly by proteolysis or reversibly through oxidation of sulphydryl groups.
Pssm-ID: 214971 [Multi-domain] Cd Length: 107 Bit Score: 147.66 E-value: 1.79e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 588 SGEAVYCDDIpRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPGFVCFISADDVPGSNITG-ICNDETVFAKDKVTCVGH 666
Cdd:smart01008 1 TGEARYGDDI-RLPGMLHAAVVRSPVAHARIKSIDTSAARAMPGVVAVLTAKDVPGLNDFGpLGPDEPVLADDKVRYVGQ 79
|
90 100
....*....|....*....|....*...
gi 91823271 667 IIGAVVADTPEHTQRAAQGVKITYEELP 694
Cdd:smart01008 80 PVAAVVAETEEAARDAAEAVKVEYEELP 107
|
|
| CutS |
COG2080 |
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and ... |
8-165 |
5.41e-38 |
|
Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, Fe-S subunit, CoxS/CutS family is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 441683 [Multi-domain] Cd Length: 155 Bit Score: 139.46 E-value: 5.41e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 8 FFVNGRKVvEKNADPETTLLAYLRRKLGLSGTKlgcgeggcgactvmlskydrlqnK----------IVHF---SANACL 74
Cdd:COG2080 6 LTVNGKPV-EVDVDPDTPLLDVLRDDLGLTGTK-----------------------FgcghgqcgacTVLVdgkAVRSCL 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 75 APICSLHHVAVTTVEGIGSTKtRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYR 154
Cdd:COG2080 62 TLAVQADGKEITTIEGLAEDG-ELHPLQQAFIEHGALQCGYCTPGMIMAAVALLDENPNPTEEEIREALSGNLCRCTGYV 140
|
170
....*....|.
gi 91823271 155 PILQGFRTFAR 165
Cdd:COG2080 141 RIVRAVKRAAA 151
|
|
| CutB |
COG1319 |
Aldehyde, CO, or xanthine dehydrogenase, FAD-binding subunit [Energy production and conversion] ... |
235-511 |
5.85e-35 |
|
Aldehyde, CO, or xanthine dehydrogenase, FAD-binding subunit [Energy production and conversion]; Aldehyde, CO, or xanthine dehydrogenase, FAD-binding subunit is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway
Pssm-ID: 440930 [Multi-domain] Cd Length: 285 Bit Score: 135.64 E-value: 5.85e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 235 TWIQASTLKELLDLKAQH-PDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLS-IVEKTL 312
Cdd:COG1319 5 EYHRPTSLEEALALLAEHgPDARVLAGGTDLLPLMKLRLARPEHLVDINRIPELRGIEEEGGGLRIGALVTHAeLAASPL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 313 VDavaklpaqktEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMDHtFFPG 392
Cdd:COG1319 85 VR----------ERYPLLAEAARAIASPQIRNRGTIGGNLANADPAADLPPALLALDATVELAGPDGERTIPAAD-FFLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 393 YRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTteVQELALCYGGMANRTISALKTTQR 472
Cdd:COG1319 154 PGETALEPGELITAVRLPAPPAGAGSAYLKVGRRASDAIALVSVAVALRLDGGT--IRDARIALGGVAPTPWRAREAEAA 231
|
250 260 270
....*....|....*....|....*....|....*....
gi 91823271 473 QLSKLWKEELLQDVCAGLAEELHlPPDAPGGMVDFRCTL 511
Cdd:COG1319 232 LAGKPLSEEAIEAAAEAAAAAAD-PIDDVRASAEYRRHL 269
|
|
| Fer2_2 |
pfam01799 |
[2Fe-2S] binding domain; |
87-158 |
2.27e-34 |
|
[2Fe-2S] binding domain;
Pssm-ID: 460336 [Multi-domain] Cd Length: 73 Bit Score: 126.01 E-value: 2.27e-34
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 91823271 87 TVEGIGSTKTrlHPVQERIAKSHGSQCGFCTPGIVMSMYTLL-RNQPEPTMEEIENAFQGNLCRCTGYRPILQ 158
Cdd:pfam01799 1 TIEGLAESGG--EPVQQAFAEAGAVQCGYCTPGMIMSAYALLeRNPPPPTEAEIREALSGNLCRCTGYRRIVD 71
|
|
| glyceraldDH_gamma |
NF041020 |
glyceraldehyde dehydrogenase subunit gamma; |
10-165 |
5.61e-29 |
|
glyceraldehyde dehydrogenase subunit gamma;
Pssm-ID: 468949 [Multi-domain] Cd Length: 162 Bit Score: 114.12 E-value: 5.61e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 10 VNGrKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYdrlqnkivhfSANACLAPICSLHHVAVTTVE 89
Cdd:NF041020 15 VNG-VWYEAEVEPRKLLVHFLRDDLGFTGTHVGCDTSTCGACTVIMNGK----------SVKSCTVLAVQADGAEITTIE 83
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 91823271 90 GIGStKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFAR 165
Cdd:NF041020 84 GLSK-DGKLHPIQEAFWENHALQCGYCTPGMIMQAYFLLKENPNPTEEEIRDGIHGNLCRCTGYQNIVKAVKEASQ 158
|
|
| CO_deh_flav_C |
pfam03450 |
CO dehydrogenase flavoprotein C-terminal domain; |
419-523 |
1.47e-25 |
|
CO dehydrogenase flavoprotein C-terminal domain;
Pssm-ID: 460921 [Multi-domain] Cd Length: 102 Bit Score: 102.25 E-value: 1.47e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 419 SAFKQASRREDDIAKVTSGMRVLFKPGTteVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHlPP 498
Cdd:pfam03450 1 AAYKQAKRRDDDIAIVNAAFRVRLDGGT--VEDARIAFGGVAPTPIRATEAEAALIGKPWDEETLEAAAALLLEDLS-PL 77
|
90 100
....*....|....*....|....*
gi 91823271 499 DAPGGMVDFRCTLTLSFFFKFYLTV 523
Cdd:pfam03450 78 SDPRGSAEYRRHLARSLLFRFLLEA 102
|
|
| 4hydroxCoAred |
TIGR03193 |
4-hydroxybenzoyl-CoA reductase, gamma subunit; 4-hydroxybenzoyl-CoA reductase converts ... |
10-164 |
2.70e-25 |
|
4-hydroxybenzoyl-CoA reductase, gamma subunit; 4-hydroxybenzoyl-CoA reductase converts 4-hydroxybenzoyl-CoA to benzoyl-CoA, a common intermediate in the degradation of aromatic compounds. This protein family represents the gamma chain of this three-subunit enzyme.
Pssm-ID: 132237 [Multi-domain] Cd Length: 148 Bit Score: 103.03 E-value: 2.70e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 10 VNGRKVVEKNADpETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLqnkivhfsanAC--LAPICSLHHVAvtT 87
Cdd:TIGR03193 6 VNGRWREDAVAD-NMLLVDYLRDTVGLTGTKQGCDGGECGACTVLVDGRPRL----------ACstLAHRVAGRKVE--T 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 91823271 88 VEGIgSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFA 164
Cdd:TIGR03193 73 VEGL-ATNGRLSRLQQAFHERLGTQCGFCTPGMIMAAEALLRRNPSPSRDEIRAALAGNLCRCTGYVKIIESVEAAA 148
|
|
| pucE |
TIGR03198 |
xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the ... |
6-165 |
1.00e-23 |
|
xanthine dehydrogenase E subunit; This gene has been characterized in B. subtilis as the Iron-sulfur cluster binding-subunit of xanthine dehydrogenase (pucE), acting in conjunction with pucC, the FAD-binding subunit and pucD, the molybdopterin binding subunit. The more common XDH complex (GenProp0640) includes the xdhA gene as the Fe-S cluster binding component.
Pssm-ID: 132242 [Multi-domain] Cd Length: 151 Bit Score: 98.77 E-value: 1.00e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 6 LVFFVNGRKVvEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSkydrlqNKIvhfsANACLAPICSLHHVAV 85
Cdd:TIGR03198 4 FRFTVNGQAW-EVAAVPTTRLSDLLRKELQLTGTKVSCGIGRCGACSVLID------GKL----ANACLTMAYQADGHEI 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 86 TTVEGIgsTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFAR 165
Cdd:TIGR03198 73 TTIEGI--AENELDPCQTAFLEEGGFQCGYCTPGMVVALKALFRETPQPSDEDMEEGLSGNLCRCTGYGGIIRSACRIRR 150
|
|
| CO_deh_flav_C |
smart01092 |
CO dehydrogenase flavoprotein C-terminal domain; |
420-523 |
2.55e-22 |
|
CO dehydrogenase flavoprotein C-terminal domain;
Pssm-ID: 215021 [Multi-domain] Cd Length: 102 Bit Score: 92.68 E-value: 2.55e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 420 AFKQASRREDDIAKVTSGMRVLFKPGTteVQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHLPPD 499
Cdd:smart01092 1 AYKKSRRRDGDIALVSAAVALTLDGGR--VTEARIALGGVAPTPKRAAEAEAALVGKPLTDEALARAAAAALAQDFTPLS 78
|
90 100
....*....|....*....|....
gi 91823271 500 APGGMVDFRCTLTLSFFFKFYLTV 523
Cdd:smart01092 79 DMRASAEYRRQLAANLLRRALLEA 102
|
|
| Se_dep_XDH |
TIGR03311 |
selenium-dependent xanthine dehydrogenase; Members of this protein resemble conventional ... |
8-165 |
6.80e-21 |
|
selenium-dependent xanthine dehydrogenase; Members of this protein resemble conventional xanthine dehydrogenase enzymes, which depend on molybdenum cofactor - molybdopterin bound to molybdate with two sulfur atoms as ligands. But all members of this family occur in species that contain markers for the biosynthesis of enzymes with a selenium-containing form of molybdenum cofactor. The member of this family from Enterococcus faecalis has been shown to act as a xanthine dehydrogenenase, and its activity if dependent on SelD (selenophosphate synthase), selenium, and molybdenum. [Purines, pyrimidines, nucleosides, and nucleotides, Other]
Pssm-ID: 132354 [Multi-domain] Cd Length: 848 Bit Score: 99.53 E-value: 6.80e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 8 FFVNGRKVVeknADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYdrlqnkivhfSANACLAPICSLHHVAVTT 87
Cdd:TIGR03311 3 FIVNGREVD---VNEEKKLLEFLREDLRLTGVKNGCGEGACGACTVIVNGK----------AVRACRFTTAKLAGKEITT 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 88 VEGigstktrLHPVQERI-----AKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCRCTGYRPILQGFRT 162
Cdd:TIGR03311 70 VEG-------LTEREKDVyawafAKAGAVQCGFCIPGMVISAKALLDKNPNPTEAEIKKALKGNICRCTGYVKIIKAVRL 142
|
...
gi 91823271 163 FAR 165
Cdd:TIGR03311 143 AAK 145
|
|
| PRK09971 |
PRK09971 |
xanthine dehydrogenase subunit XdhB; Provisional |
238-457 |
8.11e-20 |
|
xanthine dehydrogenase subunit XdhB; Provisional
Pssm-ID: 182175 [Multi-domain] Cd Length: 291 Bit Score: 91.64 E-value: 8.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 238 QASTLKELLDLKAQHPDAKLVVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDG-ISFGAACPLS------IVEK 310
Cdd:PRK09971 9 EAATLEEAIELLADNPQAKLIAGGTDVLIQLHHHNDRYRHLVSIHNIAELRGITLAEDGsIRIGAATTFTqiiedpIIQK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 311 ---TLVDAVAKLpaqktevfrgvleqlrwfAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVSRGTRRTVQMdH 387
Cdd:PRK09971 89 hlpALAEAAVSI------------------GGPQIRNVATIGGNICNGATSADSAPPLFALDAKLEIHSPNGVRFVPI-N 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 91823271 388 TFFPGYRKTLLSPEEILLSIEI-PYSREGEYFSAFKQASRREDDIAkvTSGMRVLFKPGTTEVQELALCYG 457
Cdd:PRK09971 150 GFYTGPGKVSLEHDEILVAFIIpPEPYEHAGGAYIKYAMRDAMDIA--TIGCAVLCRLDNGNFEDLRLAFG 218
|
|
| PRK11433 |
PRK11433 |
aldehyde oxidoreductase 2Fe-2S subunit; Provisional |
5-158 |
2.55e-17 |
|
aldehyde oxidoreductase 2Fe-2S subunit; Provisional
Pssm-ID: 236910 [Multi-domain] Cd Length: 217 Bit Score: 82.13 E-value: 2.55e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 5 KLVFFVNGrKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKyDRLqnkivhfsaNACLApICSLHH-V 83
Cdd:PRK11433 51 PVTLKVNG-KTEQLEVDTRTTLLDALREHLHLTGTKKGCDHGQCGACTVLVNG-RRL---------NACLT-LAVMHQgA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 84 AVTTVEGIGsTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRN---------------QPEPTMEEIENAFQGNLC 148
Cdd:PRK11433 119 EITTIEGLG-SPDNLHPMQAAFVKHDGFQCGYCTPGQICSSVAVLKEikdgipshvtvdltaAPELTADEIRERMSGNIC 197
|
170
....*....|
gi 91823271 149 RCTGYRPILQ 158
Cdd:PRK11433 198 RCGAYSNILE 207
|
|
| PRK09908 |
PRK09908 |
xanthine dehydrogenase iron sulfur-binding subunit XdhC; |
85-158 |
4.10e-15 |
|
xanthine dehydrogenase iron sulfur-binding subunit XdhC;
Pssm-ID: 182139 [Multi-domain] Cd Length: 159 Bit Score: 74.18 E-value: 4.10e-15
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 91823271 85 VTTVEGIGSTKtRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLL---RNQPEpTMEEIENAFQGNLCRCTGYRPILQ 158
Cdd:PRK09908 76 IRTLEGEAKGG-KLSHVQQAYAKSGAVQCGFCTPGLIMATTAMLakpREKPL-TITEIRRGLAGNLCRCTGYQMIVN 150
|
|
| PRK09800 |
PRK09800 |
putative hypoxanthine oxidase; Provisional |
70-158 |
1.08e-03 |
|
putative hypoxanthine oxidase; Provisional
Pssm-ID: 182084 [Multi-domain] Cd Length: 956 Bit Score: 43.67 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 91823271 70 ANACLAPICSLHHVAVTTVEGIGSTKtRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTMEEIENAFQGNLCR 149
Cdd:PRK09800 56 VNASLLIAAQLEKADIRTAESLGKWN-ELSLVQQAMVDVGVVQSGYNDPAAALIITDLLDRIAAPTREEIDDALSGLFSR 134
|
....*....
gi 91823271 150 CTGYRPILQ 158
Cdd:PRK09800 135 DAGWQQYYQ 143
|
|
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