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Conserved domains on  [gi|6654638|ref|NP_000429|]
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paired box protein Pax-3 isoform PAX3a [Homo sapiens]

Protein Classification

MarR family transcriptional regulator; ArsR family transcriptional regulator( domain architecture ID 11091156)

MarR family transcriptional regulator such as the multiple antibiotic resistance transcriptional regulator MarR, the repressor of the marRAB operon involved in the activation of both antibiotic resistance and oxidative stress genes; ArsR family transcriptional regulator containing an N-terminal ArsR family helix-turn-helix (HTH) DNA-binding domain and a C-terminal SAM-dependent methyltransferase domain, may function as a metalloregulatory transcriptional repressor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAX pfam00292
'Paired box' domain;
34-159 2.48e-83

'Paired box' domain;


:

Pssm-ID: 366005  Cd Length: 125  Bit Score: 243.24  E-value: 2.48e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638     34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPK-VATPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 6654638    114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:pfam00292  80 VVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
 
Name Accession Description Interval E-value
PAX pfam00292
'Paired box' domain;
34-159 2.48e-83

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 243.24  E-value: 2.48e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638     34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPK-VATPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 6654638    114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:pfam00292  80 VVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
PAX smart00351
Paired Box domain;
34-159 1.23e-82

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 241.46  E-value: 1.23e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638      34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPK-VATPK 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 6654638     114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:smart00351  80 VVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
 34-161 2.56e-82

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 240.78  E-value: 2.56e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638   34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:cd00131   1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPR-VATPE 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6654638  114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSK 161
Cdd:cd00131  80 VVKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
transpos_IS630 NF033545
IS630 family transposase;
56-159 2.35e-04

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 41.09  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638    56 RHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETG--SIRPGAIGGSKPKqVTTPDVEKKIEEYKRENPGMFS--- 130
Cdd:NF033545   2 RARILLLAAEGLSITEIAERLGVSRSTVYRWLKRFNEGGleGLLDKPRPGRPRK-LLSEQQAELLALLLEEPPEGAGhwt 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 6654638   131 -WEIRDKLlkDAVCDRNTvpSVSSISRILR 159
Cdd:NF033545  81 lRELAALL--EEEFGVEY--SRSTVRRLLK 106
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 58-159 1.35e-03

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 39.06  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638   58 KIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETG--SIRPGAIGGSKPKqvTTPDVEKKIEEYKRENPGMFSWEIRD 135
Cdd:COG3415  30 RAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGlaGLKDRPRGGRPSK--LSDEQRERLLELLREKSPDQGSRWTL 107

                        90       100
                ....*....|....*....|....*
gi 6654638  136 KLLKDAVCDRNTVP-SVSSISRILR 159
Cdd:COG3415 108 AELAELLEEEFGVEvSPSTVRRLLK 132
 
Name Accession Description Interval E-value
PAX pfam00292
'Paired box' domain;
34-159 2.48e-83

'Paired box' domain;


Pssm-ID: 366005  Cd Length: 125  Bit Score: 243.24  E-value: 2.48e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638     34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:pfam00292   1 GHGGVNQLGGVFVNGRPLPDHIRQKIVELAHSGVRPCDISRQLRVSHGCVSKILGRYYETGSIRPGVIGGSKPK-VATPE 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 6654638    114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:pfam00292  80 VVTKIAEYKRENPSIFAWEIRDRLLKEGVCDNDTVPSVSSINRILR 125
PAX smart00351
Paired Box domain;
34-159 1.23e-82

Paired Box domain;


Pssm-ID: 128645 [Multi-domain]  Cd Length: 125  Bit Score: 241.46  E-value: 1.23e-82
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638      34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:smart00351   1 GHGGVNQLGGVFVNGRPLPDEERQRIVELAQNGVRPCDISRQLCVSHGCVSKILGRYYETGSIRPGAIGGSKPK-VATPK 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 6654638     114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILR 159
Cdd:smart00351  80 VVKKIADYKQENPGIFAWEIRDRLLSEGVCDKDNVPSVSSINRILR 125
PAX cd00131
Paired Box domain
 34-161 2.56e-82

Paired Box domain


Pssm-ID: 238076  Cd Length: 128  Bit Score: 240.78  E-value: 2.56e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638   34 GQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKqVTTPD 113
Cdd:cd00131   1 GQGGVNQLGGVFVNGRPLPDSIRQRIVELAQSGIRPCDISRQLRVSHGCVSKILNRYYETGSIRPGAIGGSKPR-VATPE 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6654638  114 VEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSK 161
Cdd:cd00131  80 VVKKIEIYKQENPGMFAWEIRDRLLQEGVCDKSNVPSVSSINRILRNK 127
transpos_IS630 NF033545
IS630 family transposase;
56-159 2.35e-04

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 41.09  E-value: 2.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638    56 RHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETG--SIRPGAIGGSKPKqVTTPDVEKKIEEYKRENPGMFS--- 130
Cdd:NF033545   2 RARILLLAAEGLSITEIAERLGVSRSTVYRWLKRFNEGGleGLLDKPRPGRPRK-LLSEQQAELLALLLEEPPEGAGhwt 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 6654638   131 -WEIRDKLlkDAVCDRNTvpSVSSISRILR 159
Cdd:NF033545  81 lRELAALL--EEEFGVEY--SRSTVRRLLK 106
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 58-159 1.35e-03

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 39.06  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6654638   58 KIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETG--SIRPGAIGGSKPKqvTTPDVEKKIEEYKRENPGMFSWEIRD 135
Cdd:COG3415  30 RAVLLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGlaGLKDRPRGGRPSK--LSDEQRERLLELLREKSPDQGSRWTL 107

                        90       100
                ....*....|....*....|....*
gi 6654638  136 KLLKDAVCDRNTVP-SVSSISRILR 159
Cdd:COG3415 108 AELAELLEEEFGVEvSPSTVRRLLK 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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