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Conserved domains on  [gi|67191027|ref|NP_000876|]
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integrin alpha-4 isoform 1 preproprotein [Homo sapiens]

Protein Classification

integrin alpha( domain architecture ID 12192630)

integrin alpha forms a heterodimer with integrin beta to mediate cell-extracellular matrix and cell-cell interactions; integrin alpha is a component of integrin, a cell adhesion molecule that mediates cell-extracellular matrix and cell-cell interactions

CATH:  2.130.10.130|2.60.40.1510|2.60.40.1530|2.60.40.1460
Gene Ontology:  GO:0007155|GO:0008305|GO:0005178|GO:0046872
PubMed:  3028640|2199285|12297042|12826403|14689578|12361595|12234368
SCOP:  4003137

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 464-902 6.42e-138

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 422.11  E-value: 6.42e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    464 RPVVIVDASLSH-PESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVP-GYIVLFYNMSLDVNRKAESPPRFYFSSNGTS 541
Cdd:pfam08441    1 RPVVSVSASLQVePNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    542 DVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPhviSKRSTEEFPPLQPILQQkKEKDIMKKTINFARF 621
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRV---DPRAPSDLPGLKPILDQ-NQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    622 CAHEN-CSADLQVSAKIGFLKPHEnktYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKIL-ELEEKQINCE 699
Cdd:pfam08441  157 CGEDNvCVPDLQLSAKFDSRESDE---PLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRrEGSEKQLSCT 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    700 VTDNSGVVQLDCSIGYIYVDhLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMdnlKHSRVTVAIPLKYEVKLTVH 779
Cdd:pfam08441  234 AKKENSTRQVVCDLGNPMKR-GTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNS---NSNPVSLKVPVVAEAQLSLS 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    780 GFVNPTSFVYG-----SNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDkLFNILDVQTT-TGECH 853
Cdd:pfam08441  310 GVSKPDQVVGGsvkgeSAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKW-LLYLLDVQGQgKGECS 388

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67191027    854 FENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADP------------HCLNFLC 902
Cdd:pfam08441  389 PQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQtasvllscdsgaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 366-418 1.74e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.56  E-value: 1.74e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 67191027     366 ARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQ--GAIYIYNGRADGISSTFSQRI 418
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 303-352 1.41e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 63.16  E-value: 1.41e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 67191027     303 GSYFGASVCAV-DLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMN 352
Cdd:smart00191    2 GSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSI 52
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 428-479 2.62e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 45.44  E-value: 2.62e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 67191027     428 SMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESV 479
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSIPL 54
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-105 1.22e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 43.52  E-value: 1.22e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67191027      48 HNTLFGYSVVLHSHGANR---WLLVGAPTANWLAnasviNPGAIYRCRIGKNpGQTCEQLQ 105
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDgypDLLVGAPRANDAG-----ETGAVYVYFGSSG-GGNSIPLQ 55
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 464-902 6.42e-138

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 422.11  E-value: 6.42e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    464 RPVVIVDASLSH-PESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVP-GYIVLFYNMSLDVNRKAESPPRFYFSSNGTS 541
Cdd:pfam08441    1 RPVVSVSASLQVePNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    542 DVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPhviSKRSTEEFPPLQPILQQkKEKDIMKKTINFARF 621
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRV---DPRAPSDLPGLKPILDQ-NQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    622 CAHEN-CSADLQVSAKIGFLKPHEnktYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKIL-ELEEKQINCE 699
Cdd:pfam08441  157 CGEDNvCVPDLQLSAKFDSRESDE---PLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRrEGSEKQLSCT 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    700 VTDNSGVVQLDCSIGYIYVDhLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMdnlKHSRVTVAIPLKYEVKLTVH 779
Cdd:pfam08441  234 AKKENSTRQVVCDLGNPMKR-GTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNS---NSNPVSLKVPVVAEAQLSLS 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    780 GFVNPTSFVYG-----SNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDkLFNILDVQTT-TGECH 853
Cdd:pfam08441  310 GVSKPDQVVGGsvkgeSAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKW-LLYLLDVQGQgKGECS 388

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67191027    854 FENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADP------------HCLNFLC 902
Cdd:pfam08441  389 PQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQtasvllscdsgaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 366-418 1.74e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.56  E-value: 1.74e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 67191027     366 ARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQ--GAIYIYNGRADGISSTFSQRI 418
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 303-352 1.41e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 63.16  E-value: 1.41e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 67191027     303 GSYFGASVCAV-DLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMN 352
Cdd:smart00191    2 GSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSI 52
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 306-342 1.46e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 67191027    306 FGASVCAVDLNADGFSDLLVGAPmQSTIREEGRVFVY 342
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAP-GEGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 368-403 6.14e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 49.43  E-value: 6.14e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 67191027    368 FGESIVnLGDIDNDGFEDVAIGAPQEDDL-QGAIYIY 403
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAgAGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 428-479 2.62e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 45.44  E-value: 2.62e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 67191027     428 SMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESV 479
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSIPL 54
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-105 1.22e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 43.52  E-value: 1.22e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67191027      48 HNTLFGYSVVLHSHGANR---WLLVGAPTANWLAnasviNPGAIYRCRIGKNpGQTCEQLQ 105
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDgypDLLVGAPRANDAG-----ETGAVYVYFGSSG-GGNSIPLQ 55
MJ0795 COG1361
S-layer protein MJ0795, predicted component of type IV pili-like system [General function ...
 644-840 3.45e-03

S-layer protein MJ0795, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 440972 [Multi-domain]  Cd Length: 409  Bit Score: 41.22  E-value: 3.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027  644 ENKTYLAVGSMKTLMLNVSlfNAGD-DAYETTlhVKLPVGLYFIKILELEEKQI-NCEVTDNSGVVQLDCSigYIYVDHL 721
Cdd:COG1361  144 TSPDSLTPGDTGTLTLTIK--NTGTgTAKNVT--VTLTSPSGDLTDLEPGPRPAtNVVVVLSSPVSPVGSN--SVALGTL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027  722 ---SRIDISFLLDVSSlsRAEED---LSITVhaTCENEEemDNLKHSRVTVAIPLKYEVKLTVhgfVNPTSFVY-GSNDE 794
Cdd:COG1361  218 epgESATFTFKVDVSE--DAEPGpypLPLTV--TYRDED--GDTYSDTVTIGVYVAPKADFEV---ENVESTITaGETVT 288

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 67191027  795 nepetcmvekmnLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLF 840
Cdd:COG1361  289 ------------ITITVTNTGNETAKNVVARLSADDPLSSLDDEAF 322
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 464-902 6.42e-138

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 422.11  E-value: 6.42e-138
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    464 RPVVIVDASLSH-PESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVP-GYIVLFYNMSLDVNRKAESPPRFYFSSNGTS 541
Cdd:pfam08441    1 RPVVSVSASLQVePNSINPEKKNCTLTGTPVSCFTVRACFSYTGKPIPnPSLVLNYELELDRQKKKGLPPRVLFLDSQQP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    542 DVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPhviSKRSTEEFPPLQPILQQkKEKDIMKKTINFARF 621
Cdd:pfam08441   81 SLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRV---DPRAPSDLPGLKPILDQ-NQPSTVQEQANFLKD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    622 CAHEN-CSADLQVSAKIGFLKPHEnktYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKIL-ELEEKQINCE 699
Cdd:pfam08441  157 CGEDNvCVPDLQLSAKFDSRESDE---PLLLGDDNDLALEITVTNLGEDAYEAELYVTLPPGLDYSGVRrEGSEKQLSCT 233

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    700 VTDNSGVVQLDCSIGYIYVDhLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMdnlKHSRVTVAIPLKYEVKLTVH 779
Cdd:pfam08441  234 AKKENSTRQVVCDLGNPMKR-GTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQNS---NSNPVSLKVPVVAEAQLSLS 309

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027    780 GFVNPTSFVYG-----SNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDkLFNILDVQTT-TGECH 853
Cdd:pfam08441  310 GVSKPDQVVGGsvkgeSAMKPRSEEDIGPLVEHTYEVINNGPSTVSGASLEISWPYELSNGKW-LLYLLDVQGQgKGECS 388

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67191027    854 FENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADP------------HCLNFLC 902
Cdd:pfam08441  389 PQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQtasvllscdsgaRCVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 366-418 1.74e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.56  E-value: 1.74e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 67191027     366 ARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQ--GAIYIYNGRADGISSTFSQRI 418
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGetGAVYVYFGSSGGGNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 303-352 1.41e-12

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 63.16  E-value: 1.41e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 67191027     303 GSYFGASVCAV-DLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMN 352
Cdd:smart00191    2 GSYFGYSVAGVgDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSI 52
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 306-342 1.46e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 51.36  E-value: 1.46e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 67191027    306 FGASVCAVDLNADGFSDLLVGAPmQSTIREEGRVFVY 342
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAP-GEGGAGAGAVYVL 36
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 368-403 6.14e-08

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 49.43  E-value: 6.14e-08
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 67191027    368 FGESIVnLGDIDNDGFEDVAIGAPQEDDL-QGAIYIY 403
Cdd:pfam01839    1 FGYSVA-VGDLNGDGYADLAVGAPGEGGAgAGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 314-388 3.84e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 47.99  E-value: 3.84e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67191027    314 DLNADGFSDLLVGapmqstirEEGRVFVYINSGSGAVMNAMETNLVGSDKYAArfgesiVNLGDIDNDGFEDVAI 388
Cdd:pfam13517    1 DLDGDGKLDLVVA--------NDGGLRLYLNNGDGTFTFITSVSLGGGGGGLS------VAVGDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 428-479 2.62e-06

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 45.44  E-value: 2.62e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 67191027     428 SMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESV 479
Cdd:smart00191    3 SYFGYSVAGVGDVNGDGYPDLLVGAPRANDAGETGAVYVYFGSSGGGNSIPL 54
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 48-105 1.22e-05

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 43.52  E-value: 1.22e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 67191027      48 HNTLFGYSVVLHSHGANR---WLLVGAPTANWLAnasviNPGAIYRCRIGKNpGQTCEQLQ 105
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDgypDLLVGAPRANDAG-----ETGAVYVYFGSSG-GGNSIPLQ 55
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 377-450 2.68e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 39.90  E-value: 2.68e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 67191027    377 DIDNDGFEDVAIGAPqeddlqGAIYIYNGRADGiSSTFSQRIEGLQISKSLSM-FGqsisgqiDADNNGYVDVAV 450
Cdd:pfam13517    1 DLDGDGKLDLVVAND------GGLRLYLNNGDG-TFTFITSVSLGGGGGGLSVaVG-------DLDGDGRLDLLV 61
MJ0795 COG1361
S-layer protein MJ0795, predicted component of type IV pili-like system [General function ...
 644-840 3.45e-03

S-layer protein MJ0795, predicted component of type IV pili-like system [General function prediction only];


Pssm-ID: 440972 [Multi-domain]  Cd Length: 409  Bit Score: 41.22  E-value: 3.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027  644 ENKTYLAVGSMKTLMLNVSlfNAGD-DAYETTlhVKLPVGLYFIKILELEEKQI-NCEVTDNSGVVQLDCSigYIYVDHL 721
Cdd:COG1361  144 TSPDSLTPGDTGTLTLTIK--NTGTgTAKNVT--VTLTSPSGDLTDLEPGPRPAtNVVVVLSSPVSPVGSN--SVALGTL 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 67191027  722 ---SRIDISFLLDVSSlsRAEED---LSITVhaTCENEEemDNLKHSRVTVAIPLKYEVKLTVhgfVNPTSFVY-GSNDE 794
Cdd:COG1361  218 epgESATFTFKVDVSE--DAEPGpypLPLTV--TYRDED--GDTYSDTVTIGVYVAPKADFEV---ENVESTITaGETVT 288

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 67191027  795 nepetcmvekmnLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLF 840
Cdd:COG1361  289 ------------ITITVTNTGNETAKNVVARLSADDPLSSLDDEAF 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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