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Conserved domains on  [gi|48255947|ref|NP_001001323|]
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plasma membrane calcium-transporting ATPase 1 isoform 1a [Homo sapiens]

Protein Classification

calcium-translocating P-type ATPase( domain architecture ID 11492721)

calcium-translocating P-type ATPase catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
15-1064 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


:

Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1445.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947     15 KNSLKEANHDGDFGITLAELRALMELRSTDALRK---IQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIP 91
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947     92 PKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGdnalcgevsvgEEEGEGETGWIEGAAILLSVVCVVLVTA 171
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPSVG-----------EDKADTETGWIEGVAILVSVILVVLVTA 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    172 FNDWSKEKQFRGLQsRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVK 251
Cdd:TIGR01517  150 VNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIK 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    252 KSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGeeeekkdekkkekknkkqdgaienrnkakaqdgaam 331
Cdd:TIGR01517  229 KGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG------------------------------------ 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    332 emqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPwlaECTPI 411
Cdd:TIGR01517  273 -------------------------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEE 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    412 YIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAY 491
Cdd:TIGR01517  325 DAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGY 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    492 INEKHYKKVPEpeaIPPNILSYLVTGISVNCAYTSKILPPEKE-GGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEE 570
Cdd:TIGR01517  405 IGEQRFNVRDE---IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEE 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    571 ALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPrDRDDIVKTVIEPMASEGLRTICL 650
Cdd:TIGR01517  482 KVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICL 560
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    651 AFRDFPaGEPEPEWDNENdivTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEd 730
Cdd:TIGR01517  561 AYRDFA-PEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG- 635
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    731 fLCLEGKDFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADV 810
Cdd:TIGR01517  636 -LAMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAPALKLADV 701
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    811 GFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQML 888
Cdd:TIGR01517  702 GFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLL 781
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    889 WVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPlHAPP 968
Cdd:TIGR01517  782 WVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQ 860
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    969 SEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLG 1048
Cdd:TIGR01517  861 GELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLG 940
                         1050
                   ....*....|....*.
gi 48255947   1049 MGTLLWGQLISTIPTS 1064
Cdd:TIGR01517  941 MLSLIFGVLLRLIPVE 956
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1103-1142 2.05e-12

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


:

Pssm-ID: 463575  Cd Length: 47  Bit Score: 62.81  E-value: 2.05e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 48255947   1103 GQILWFRGLNRIQTQMDVVNAFQSG--SSIQGALRRQpSIAS 1142
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSlrEGIQKPYLRN-SIHS 41
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
15-1064 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1445.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947     15 KNSLKEANHDGDFGITLAELRALMELRSTDALRK---IQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIP 91
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947     92 PKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGdnalcgevsvgEEEGEGETGWIEGAAILLSVVCVVLVTA 171
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPSVG-----------EDKADTETGWIEGVAILVSVILVVLVTA 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    172 FNDWSKEKQFRGLQsRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVK 251
Cdd:TIGR01517  150 VNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIK 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    252 KSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGeeeekkdekkkekknkkqdgaienrnkakaqdgaam 331
Cdd:TIGR01517  229 KGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG------------------------------------ 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    332 emqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPwlaECTPI 411
Cdd:TIGR01517  273 -------------------------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEE 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    412 YIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAY 491
Cdd:TIGR01517  325 DAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGY 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    492 INEKHYKKVPEpeaIPPNILSYLVTGISVNCAYTSKILPPEKE-GGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEE 570
Cdd:TIGR01517  405 IGEQRFNVRDE---IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEE 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    571 ALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPrDRDDIVKTVIEPMASEGLRTICL 650
Cdd:TIGR01517  482 KVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICL 560
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    651 AFRDFPaGEPEPEWDNENdivTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEd 730
Cdd:TIGR01517  561 AYRDFA-PEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG- 635
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    731 fLCLEGKDFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADV 810
Cdd:TIGR01517  636 -LAMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAPALKLADV 701
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    811 GFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQML 888
Cdd:TIGR01517  702 GFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLL 781
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    889 WVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPlHAPP 968
Cdd:TIGR01517  782 WVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQ 860
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    969 SEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLG 1048
Cdd:TIGR01517  861 GELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLG 940
                         1050
                   ....*....|....*.
gi 48255947   1049 MGTLLWGQLISTIPTS 1064
Cdd:TIGR01517  941 MLSLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
78-928 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1266.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   78 LERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNAlcgevsvgeeegegETGWIEGA 157
Cdd:cd02081    1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEGEG--------------KTGWIEGV 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  158 AILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLK 237
Cdd:cd02081   67 AILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLK 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  238 IDESSLTGESDHVKKSLD---KDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGeeeekkdekkkekknkkqd 314
Cdd:cd02081  146 IDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAEN------------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  315 gaienrnkakaqdgaamemqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVI 394
Cdd:cd02081  207 ------------------------------------------EEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFII 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  395 DTFWVQKRPWlaecTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICS 474
Cdd:cd02081  245 DGFVNDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 320
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  475 DKTGTLTMNRMTVVQAYInekhykkvpepeaippnilsylvtgisvncaytskilppekegglprhvGNKTECALLGLLL 554
Cdd:cd02081  321 DKTGTLTQNRMTVVQGYI-------------------------------------------------GNKTECALLGFVL 351
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  555 DLKRDYQdVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEaKVFRPRDRDDIVK 634
Cdd:cd02081  352 ELGGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIK 429
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  635 TVIEPMASEGLRTICLAFRDFPAGEPEPE---WDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDN 711
Cdd:cd02081  430 RVIEPMASDSLRTIGLAYRDFSPDEEPTAerdWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDN 509
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  712 INTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDStvsdqRQV 791
Cdd:cd02081  510 INTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEV 584
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  792 VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAF 871
Cdd:cd02081  585 VAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAF 664
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 48255947  872 TGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTM 928
Cdd:cd02081  665 IGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
59-1058 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 666.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   59 ICTKLKTSPnEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSL---------------- 122
Cdd:COG0474   16 VLAELGTSE-EGLS--SEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISAllgdwvdaivilavvl 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  123 ---GLSFYQppegdnalcgevsvgeeegegetgwiegaaillsvvcvvlvtafnDWSKEKQFRGLQSRIEQeqKFTVIRG 199
Cdd:COG0474   93 lnaIIGFVQ---------------------------------------------EYRAEKALEALKKLLAP--TARVLRD 125
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  200 GQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS----------LDKDPLLLSGTHVMEG 269
Cdd:COG0474  126 GKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSadplpedaplGDRGNMVFMGTLVTSG 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  270 SGRMVVTAVGVNSQTGIIFTLLGAGgeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdk 349
Cdd:COG0474  206 RGTAVVVATGMNTEFGKIAKLLQEA------------------------------------------------------- 230
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  350 kkanlpKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLyfvidtfwvQKRPWLAectpiyiqyfvkFFIIGVTVLVV 429
Cdd:COG0474  231 ------EEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGLL---------RGGPLLE------------ALLFAVALAVA 283
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  430 AVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYkkvpEPEAIPPN 509
Cdd:COG0474  284 AIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDP 359
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  510 ILSYLVTGISVNCAYTskiLPPEKEgglprhVGNKTECALLGLLLDLKRDYQDVRNEIPEEAlykVYTFNSVRKSMSTVL 589
Cdd:COG0474  360 ALEELLRAAALCSDAQ---LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYPRVD---EIPFDSERKRMSTVH 427
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  590 KNSDGSYRIFSKGASEIILKKCFKILsANGEAKVFRPRDRDDIVKTVIEpMASEGLRTICLAFRDFPAGEPEPEWDNEND 669
Cdd:COG0474  428 EDPDGKRLLIVKGAPEVVLALCTRVL-TGGGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELDSEDDESD 505
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  670 ivtgLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDflCLEGKDFNRrirneKGE 749
Cdd:COG0474  506 ----LTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA-----MSD 574
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  750 IE-QERIDKIwpklRVLARSSPTDKHTLVKGIidstvsdQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 826
Cdd:COG0474  575 EElAEAVEDV----DVFARVSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAA 643
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  827 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEP 906
Cdd:COG0474  644 DIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEP 723
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  907 PTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFfdidsgrnaplHAPPSEHYTIVFNTFVLMQLFN 986
Cdd:COG0474  724 VEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALALAR-----------GASLALARTMAFTTLVLSQLFN 792
                        970       980       990      1000      1010      1020      1030
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48255947  987 EINARKIHgeRNVFE-GIFNNAIFCTIVLGTFVVQIIIVQ--FGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLI 1058
Cdd:COG0474  793 VFNCRSER--RSFFKsGLFPNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
880-1058 9.51e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 170.88  E-value: 9.51e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    880 SPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSG 959
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    960 RNAplhappsehYTIVFNTFVLMQLFNEINARKIHGERNVFeGIFNNAIFCTIVLGTFVVQIIIVQ--FGGKPFSCSELS 1037
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 48255947   1038 IEQWLWSIFLGMGTLLWGQLI 1058
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
195-870 1.18e-42

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 169.09  E-value: 1.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   195 TVIRGGQV------IQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKK-----------SLDKD 257
Cdd:PRK10517  162 TVLRVINDkgengwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECD 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   258 PLLLSGTHVMEGSGRMVVTAVGVNSQtgiiFtllgaggeeeekkdekkkekknkkqdGAIENRnkAKAQDGAAMEMQplk 337
Cdd:PRK10517  242 TLCFMGTNVVSGTAQAVVIATGANTW----F--------------------------GQLAGR--VSEQDSEPNAFQ--- 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   338 seeggdgdekdkkkanlpkkeksvlQGkltklavqIGKAGLLMSAITVIILVLYFVIDTFwvQKRPWlaectpiyiqyfV 417
Cdd:PRK10517  287 -------------------------QG--------ISRVSWLLIRFMLVMAPVVLLINGY--TKGDW------------W 319
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   418 KFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRM------------ 485
Cdd:PRK10517  320 EAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIvlenhtdisgkt 399
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   486 ---TVVQAYINekhykkvpepeaippnilSYLVTGIsvncaytsKILppekeggLPRHVgnkTECALLGLLLDLKRDYQD 562
Cdd:PRK10517  400 serVLHSAWLN------------------SHYQTGL--------KNL-------LDTAV---LEGVDEESARSLASRWQK 443
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   563 VrNEIPeealykvytFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKIlSANGEAKVFRPRDRDDIvKTVIEPMAS 642
Cdd:PRK10517  444 I-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEILNVCSQV-RHNGEIVPLDDIMLRRI-KRVTDTLNR 511
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   643 EGLRTICLAFRDFPAGEPEPEWDNENDivtgLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKC 722
Cdd:PRK10517  512 QGLRVVAVATKYLPAREGDYQRADESD----LILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEV 587
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   723 GILHPGedflCLEGKDFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDG 802
Cdd:PRK10517  588 GLDAGE----VLIGSDIET--------LSDDELANLAERTTLFARLTPMHKERIVT-----LLKREGHVVGFMGDGINDA 650
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48255947   803 PALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 870
Cdd:PRK10517  651 PALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1103-1142 2.05e-12

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 62.81  E-value: 2.05e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 48255947   1103 GQILWFRGLNRIQTQMDVVNAFQSG--SSIQGALRRQpSIAS 1142
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSlrEGIQKPYLRN-SIHS 41
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
59-124 1.09e-10

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 58.75  E-value: 1.09e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48255947      59 ICTKLKTSPNEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGL 124
Cdd:smart00831   12 VLERLQTDLEKGLS--SEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
 
Name Accession Description Interval E-value
ATPase-IIB_Ca TIGR01517
plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase ...
15-1064 0e+00

plasma-membrane calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes, out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) which are represented by two corresponding models (TIGR01116 and TIGR01522). This model is well separated from those.


Pssm-ID: 273668 [Multi-domain]  Cd Length: 956  Bit Score: 1445.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947     15 KNSLKEANHDGDFGITLAELRALMELRSTDALRK---IQESYGDVYGICTKLKTSPNEGLSGNPADLERREAVFGKNFIP 91
Cdd:TIGR01517    1 MESVRRRTSIRDNFTDGFDVGVSILTDLTDIFKKampLYEKLGGAEGIATKLKTDLNEGVRLSSSTLERREKVYGKNELP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947     92 PKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGdnalcgevsvgEEEGEGETGWIEGAAILLSVVCVVLVTA 171
Cdd:TIGR01517   81 EKPPKSFLQIVWAALSDQTLILLSVAAVVSLVLGLYVPSVG-----------EDKADTETGWIEGVAILVSVILVVLVTA 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    172 FNDWSKEKQFRGLQsRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVK 251
Cdd:TIGR01517  150 VNDYKKELQFRQLN-REKSAQKIAVIRGGQEQQISIHDIVVGDIVSLSTGDVVPADGVFISGLSLEIDESSITGESDPIK 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    252 KSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGeeeekkdekkkekknkkqdgaienrnkakaqdgaam 331
Cdd:TIGR01517  229 KGPVQDPFLLSGTVVNEGSGRMLVTAVGVNSFGGKLMMELRQAG------------------------------------ 272
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    332 emqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKRPwlaECTPI 411
Cdd:TIGR01517  273 -------------------------EEETPLQEKLSELAGLIGKFGMGSAVLLFLVLSLRYVFRIIRGDGRF---EDTEE 324
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    412 YIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAY 491
Cdd:TIGR01517  325 DAQTFLDHFIIAVTIVVVAVPEGLPLAVTIALAYSMKKMMKDNNLVRHLAACETMGSATAICSDKTGTLTQNVMSVVQGY 404
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    492 INEKHYKKVPEpeaIPPNILSYLVTGISVNCAYTSKILPPEKE-GGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEE 570
Cdd:TIGR01517  405 IGEQRFNVRDE---IVLRNLPAAVRNILVEGISLNSSSEEVVDrGGKRAFIGSKTECALLDFGLLLLLQSRDVQEVRAEE 481
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    571 ALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPrDRDDIVKTVIEPMASEGLRTICL 650
Cdd:TIGR01517  482 KVVKIYPFNSERKFMSVVVKHSGGKYREFRKGASEIVLKPCRKRLDSNGEATPISE-DDKDRCADVIEPLASDALRTICL 560
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    651 AFRDFPaGEPEPEWDNENdivTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEd 730
Cdd:TIGR01517  561 AYRDFA-PEEFPRKDYPN---KGLTLIGVVGIKDPLRPGVREAVQECQRAGITVRMVTGDNIDTAKAIARNCGILTFGG- 635
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    731 fLCLEGKDFNRRIRNEkgeieqerIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADV 810
Cdd:TIGR01517  636 -LAMEGKEFRSLVYEE--------MDPILPKLRVLARSSPLDKQLLVL-----MLKDMGEVVAVTGDGTNDAPALKLADV 701
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    811 GFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACIT--QDSPLKAVQML 888
Cdd:TIGR01517  702 GFSMGISGTEVAKEASDIILLDDNFASIVRAVKWGRNVYDNIRKFLQFQLTVNVVAVILTFVGSCISssHTSPLTAVQLL 781
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    889 WVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPlHAPP 968
Cdd:TIGR01517  782 WVNLIMDTLAALALATEPPTEALLDRKPIGRNAPLISRSMWKNILGQAGYQLVVTFILLFAGGSIFDVSGPDEIT-SHQQ 860
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    969 SEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFGGKPFSCSELSIEQWLWSIFLG 1048
Cdd:TIGR01517  861 GELNTIVFNTFVLLQLFNEINARKLYEGMNVFEGLFKNRIFVTIMGFTFGFQVIIVEFGGSFFSTVSLSIEQWIGCVLLG 940
                         1050
                   ....*....|....*.
gi 48255947   1049 MGTLLWGQLISTIPTS 1064
Cdd:TIGR01517  941 MLSLIFGVLLRLIPVE 956
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
78-928 0e+00

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 1266.35  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   78 LERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNAlcgevsvgeeegegETGWIEGA 157
Cdd:cd02081    1 LEHRREVYGKNEIPPKPPKSFLQLVWEALQDPTLIILLIAAIVSLGLGFYTPFGEGEG--------------KTGWIEGV 66
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  158 AILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEqEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLK 237
Cdd:cd02081   67 AILVAVILVVLVTAGNDYQKEKQFRKLNSKKE-DQKVTVIRDGEVIQISVFDIVVGDIVQLKYGDLIPADGLLIEGNDLK 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  238 IDESSLTGESDHVKKSLD---KDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAGGeeeekkdekkkekknkkqd 314
Cdd:cd02081  146 IDESSLTGESDPIKKTPDnqiPDPFLLSGTKVLEGSGKMLVTAVGVNSQTGKIMTLLRAEN------------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  315 gaienrnkakaqdgaamemqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVI 394
Cdd:cd02081  207 ------------------------------------------EEKTPLQEKLTKLAVQIGKVGLIVAALTFIVLIIRFII 244
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  395 DTFWVQKRPWlaecTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICS 474
Cdd:cd02081  245 DGFVNDGKSF----SAEDLQEFVNFFIIAVTIIVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 320
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  475 DKTGTLTMNRMTVVQAYInekhykkvpepeaippnilsylvtgisvncaytskilppekegglprhvGNKTECALLGLLL 554
Cdd:cd02081  321 DKTGTLTQNRMTVVQGYI-------------------------------------------------GNKTECALLGFVL 351
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  555 DLKRDYQdVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSANGEaKVFRPRDRDDIVK 634
Cdd:cd02081  352 ELGGDYR-YREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGASEIVLKKCSYILNSDGE-VVFLTSEKKEEIK 429
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  635 TVIEPMASEGLRTICLAFRDFPAGEPEPE---WDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDN 711
Cdd:cd02081  430 RVIEPMASDSLRTIGLAYRDFSPDEEPTAerdWDDEEDIESDLTFIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDN 509
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  712 INTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDStvsdqRQV 791
Cdd:cd02081  510 INTARAIARECGILTEGEDGLVLEGKEFRELIDEEVGEVCQEKFDKIWPKLRVLARSSPEDKYTLVKGLKDS-----GEV 584
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  792 VAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAF 871
Cdd:cd02081  585 VAVTGDGTNDAPALKKADVGFAMGIAGTEVAKEASDIILLDDNFSSIVKAVMWGRNVYDSIRKFLQFQLTVNVVAVILAF 664
                        810       820       830       840       850
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 48255947  872 TGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTM 928
Cdd:cd02081  665 IGAVVTKDSPLTAVQMLWVNLIMDTLAALALATEPPTEDLLKRKPYGRDKPLISRTM 721
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
59-1058 0e+00

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 440242 [Multi-domain]  Cd Length: 874  Bit Score: 666.42  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   59 ICTKLKTSPnEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSL---------------- 122
Cdd:COG0474   16 VLAELGTSE-EGLS--SEEAARRLARYGPNELPEEKKRSLLRRFLEQFKNPLILILLAAAVISAllgdwvdaivilavvl 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  123 ---GLSFYQppegdnalcgevsvgeeegegetgwiegaaillsvvcvvlvtafnDWSKEKQFRGLQSRIEQeqKFTVIRG 199
Cdd:COG0474   93 lnaIIGFVQ---------------------------------------------EYRAEKALEALKKLLAP--TARVLRD 125
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  200 GQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS----------LDKDPLLLSGTHVMEG 269
Cdd:COG0474  126 GKWVEIPAEELVPGDIVLLEAGDRVPADLRLLEAKDLQVDESALTGESVPVEKSadplpedaplGDRGNMVFMGTLVTSG 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  270 SGRMVVTAVGVNSQTGIIFTLLGAGgeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdk 349
Cdd:COG0474  206 RGTAVVVATGMNTEFGKIAKLLQEA------------------------------------------------------- 230
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  350 kkanlpKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLyfvidtfwvQKRPWLAectpiyiqyfvkFFIIGVTVLVV 429
Cdd:COG0474  231 ------EEEKTPLQKQLDRLGKLLAIIALVLAALVFLIGLL---------RGGPLLE------------ALLFAVALAVA 283
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  430 AVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYkkvpEPEAIPPN 509
Cdd:COG0474  284 AIPEGLPAVVTITLALGAQRMAKRNAIVRRLPAVETLGSVTVICTDKTGTLTQNKMTVERVYTGGGTY----EVTGEFDP 359
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  510 ILSYLVTGISVNCAYTskiLPPEKEgglprhVGNKTECALLGLLLDLKRDYQDVRNEIPEEAlykVYTFNSVRKSMSTVL 589
Cdd:COG0474  360 ALEELLRAAALCSDAQ---LEEETG------LGDPTEGALLVAAAKAGLDVEELRKEYPRVD---EIPFDSERKRMSTVH 427
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  590 KNSDGSYRIFSKGASEIILKKCFKILsANGEAKVFRPRDRDDIVKTVIEpMASEGLRTICLAFRDFPAGEPEPEWDNEND 669
Cdd:COG0474  428 EDPDGKRLLIVKGAPEVVLALCTRVL-TGGGVVPLTEEDRAEILEAVEE-LAAQGLRVLAVAYKELPADPELDSEDDESD 505
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  670 ivtgLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDflCLEGKDFNRrirneKGE 749
Cdd:COG0474  506 ----LTFLGLVGMIDPPRPEAKEAIAECRRAGIRVKMITGDHPATARAIARQLGLGDDGDR--VLTGAELDA-----MSD 574
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  750 IE-QERIDKIwpklRVLARSSPTDKHTLVKGIidstvsdQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 826
Cdd:COG0474  575 EElAEAVEDV----DVFARVSPEHKLRIVKAL-------QANghVVAMTGDGVNDAPALKAADIGIAMGITGTDVAKEAA 643
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  827 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEP 906
Cdd:COG0474  644 DIVLLDDNFATIVAAVEEGRRIYDNIRKFIKYLLSSNFGEVLSVLLASLLGLPLPLTPIQILWINLVTDGLPALALGFEP 723
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  907 PTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFfdidsgrnaplHAPPSEHYTIVFNTFVLMQLFN 986
Cdd:COG0474  724 VEPDVMKRPPRWPDEPILSRFLLLRILLLGLLIAIFTLLTFALALAR-----------GASLALARTMAFTTLVLSQLFN 792
                        970       980       990      1000      1010      1020      1030
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48255947  987 EINARKIHgeRNVFE-GIFNNAIFCTIVLGTFVVQIIIVQ--FGGKPFSCSELSIEQWLWSIFLGMGTLLWGQLI 1058
Cdd:COG0474  793 VFNCRSER--RSFFKsGLFPNRPLLLAVLLSLLLQLLLIYvpPLQALFGTVPLPLSDWLLILGLALLYLLLVELV 865
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
70-916 2.35e-160

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 492.90  E-value: 2.35e-160
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   70 GLSGNPAdlERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYqppegdnalcgevsvgeeegeg 149
Cdd:cd02089    1 GLSEEEA--ERRLAKYGPNELVEKKKRSPWKKFLEQFKDFMVIVLLAAAVISGVLGEY---------------------- 56
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  150 etgwIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRieQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGI 229
Cdd:cd02089   57 ----VDAIVIIAIVILNAVLGFVQEYKAEKALAALKKM--SAPTAKVLRDGKKQEIPARELVPGDIVLLEAGDYVPADGR 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  230 LIQGNDLKIDESSLTGESDHVKKSLDKDP-----------LLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGAggeee 298
Cdd:cd02089  131 LIESASLRVEESSLTGESEPVEKDADTLLeedvplgdrknMVFSGTLVTYGRGRAVVTATGMNTEMGKIATLLEE----- 205
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  299 ekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdkkkanlPKKEKSVLQGKLTKLAVQIGKAGL 378
Cdd:cd02089  206 --------------------------------------------------------TEEEKTPLQKRLDQLGKRLAIAAL 229
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  379 lmsAITVIILVLYfvidtfWVQKRPWLAEctpiyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVR 458
Cdd:cd02089  230 ---IICALVFALG------LLRGEDLLDM------------LLTAVSLAVAAIPEGLPAIVTIVLALGVQRMAKRNAIIR 288
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  459 HLDACETMGNATAICSDKTGTLTMNRMTVVQAYinekhykkvpepeaippnilsylvtgisvncaytskilppekegglp 538
Cdd:cd02089  289 KLPAVETLGSVSVICSDKTGTLTQNKMTVEKIY----------------------------------------------- 321
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  539 rHVGNKTECALLGLLLDLKRDYQDVR------NEIPeealykvytFNSVRKSMSTVLKNSDGsYRIFSKGASEIILKKCF 612
Cdd:cd02089  322 -TIGDPTETALIRAARKAGLDKEELEkkypriAEIP---------FDSERKLMTTVHKDAGK-YIVFTKGAPDVLLPRCT 390
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  613 KILSaNGEAKVFRPRDRDDIvKTVIEPMASEGLRTICLAFRDFPAGEPEPEWDNENDivtgLTCIAVVGIEDPVRPEVPD 692
Cdd:cd02089  391 YIYI-NGQVRPLTEEDRAKI-LAVNEEFSEEALRVLAVAYKPLDEDPTESSEDLEND----LIFLGLVGMIDPPRPEVKD 464
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  693 AIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEdfLCLEGKDFNrrirnekgEIEQERIDKIWPKLRVLARSSPTD 772
Cdd:cd02089  465 AVAECKKAGIKTVMITGDHKLTARAIAKELGILEDGD--KALTGEELD--------KMSDEELEKKVEQISVYARVSPEH 534
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  773 KHTLVKgiidstvSDQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYD 850
Cdd:cd02089  535 KLRIVK-------ALQRKgkIVAMTGDGVNDAPALKAADIGVAMGITGTDVAKEAADMILTDDNFATIVAAVEEGRTIYD 607
                        810       820       830       840       850       860
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48255947  851 SISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKP 916
Cdd:cd02089  608 NIRKFIRYLLSGNVGEILTMLLAPLLGWPVPLLPIQLLWINLLTDGLPALALGVEPAEPDIMDRKP 673
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
171-902 3.82e-139

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 432.51  E-value: 3.82e-139
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    171 AFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQViQIPVADITVGDIAQVKYGDLLPADGILIQGnDLKIDESSLTGESDHV 250
Cdd:TIGR01494   14 VKQKLKAEDALRSLKDSLVNTATVLVLRNGWK-EISSKDLVPGDVVLVKSGDTVPADGVLLSG-SAFVDESSLTGESLPV 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    251 -KKSLDKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdekkkekknkkqdgaienrnkakaqdGA 329
Cdd:TIGR01494   92 lKTALPDGDAVFAGTINFGGTLIVKVTATGILTTVGKI----------------------------------------AV 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    330 AMEmqplkseEGGDGdekdkkkanlpkkeKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDtfwvqkrpwlaect 409
Cdd:TIGR01494  132 VVY-------TGFST--------------KTPLQSKADKFENFIFILFLLLLALAVFLLLPIGGWD-------------- 176
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    410 piyIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQ 489
Cdd:TIGR01494  177 ---GNSIYKAILRALAVLVIAIPCALPLAVSVALAVGDARMAKKGILVKNLNALEELGKVDVICFDKTGTLTTNKMTLQK 253
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    490 AYINEKHYKKvpepeaippnilsylvtgisvncaytsKILPPEKEGGLPRHVGNKTECALLGLLldlkRDYQDVRNEIPE 569
Cdd:TIGR01494  254 VIIIGGVEEA---------------------------SLALALLAASLEYLSGHPLERAIVKSA----EGVIKSDEINVE 302
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    570 EALYKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKIlsangeakvfrprdrdDIVKTVIEPMASEGLRTIC 649
Cdd:TIGR01494  303 YKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEFVLERCNNE----------------NDYDEKVDEYARQGLRVLA 366
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    650 LAFRDFPagepepewdnendivTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILhpge 729
Cdd:TIGR01494  367 FASKKLP---------------DDLEFLGLLTFEDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID---- 427
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    730 dflclegkdfnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIIDSTvsdqrQVVAVTGDGTNDGPALKKAD 809
Cdd:TIGR01494  428 ----------------------------------VFARVKPEEKAAIVEALQEKG-----RTVAMTGDGVNDAPALKKAD 468
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    810 VGFAMGIAgtDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACItqdsplkavqmlw 889
Cdd:TIGR01494  469 VGIAMGSG--DVAKAAADIVLLDDDLSTIVEAVKEGRKTFSNIKKNIFWAIAYNLILIPLALLLIVI------------- 533
                          730
                   ....*....|...
gi 48255947    890 vNLIMDTLASLAL 902
Cdd:TIGR01494  534 -ILLPPLLAALAL 545
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
70-1042 4.56e-138

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 439.01  E-value: 4.56e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   70 GLSGNPAdlERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYqppegdnalcgevsvgeeegeg 149
Cdd:cd02080    1 GLTSEEA--AERLERYGPNRLPEKKTKSPLLRFLRQFNNPLIYILLAAAVVTAFLGHW---------------------- 56
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  150 etgwiEGAAILLSVVCVVLVTAFNDWSK-EKQFRGLQSRIEQEQkfTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADG 228
Cdd:cd02080   57 -----VDAIVIFGVVLINAIIGYIQEGKaEKALAAIKNMLSPEA--TVLRDGKKLTIDAEELVPGDIVLLEAGDKVPADL 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  229 ILIQGNDLKIDESSLTGESDHVKKSLDKDP----------LLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeee 298
Cdd:cd02080  130 RLIEARNLQIDESALTGESVPVEKQEGPLEedtplgdrknMAYSGTLVTAGSATGVVVATGADTEIGRINQLLA------ 203
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  299 ekkdekkkekknkkqdgaienrnkakaqdgaamEMQPLKSeeggdgdekdkkkanlPkkeksvLQGKLTKLAVQIGKAGL 378
Cdd:cd02080  204 ---------------------------------EVEQLAT----------------P------LTRQIAKFSKALLIVIL 228
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  379 LMSAITVIIlvlyfvidTFWVQKRPWlaectpiyiqyfVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVR 458
Cdd:cd02080  229 VLAALTFVF--------GLLRGDYSL------------VELFMAVVALAVAAIPEGLPAVITITLAIGVQRMAKRNAIIR 288
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  459 HLDACETMGNATAICSDKTGTLTMNRMTVVQAYI--NEkhykkvpepeaippnilSYLvtgisvncaytskilppEKEGG 536
Cdd:cd02080  289 RLPAVETLGSVTVICSDKTGTLTRNEMTVQAIVTlcND-----------------AQL-----------------HQEDG 334
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  537 LPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEAlykVYTFNSVRKSMSTvLKNSDGSYRIFSKGASEIILKKCFKILS 616
Cdd:cd02080  335 HWKITGDPTEGALLVLAAKAGLDPDRLASSYPRVD---KIPFDSAYRYMAT-LHRDDGQRVIYVKGAPERLLDMCDQELL 410
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  617 ANGEakvfRPRDRDDIVKTViEPMASEGLRTICLAFRDFPAGEPEPEwdnENDIVTGLTCIAVVGIEDPVRPEVPDAIKK 696
Cdd:cd02080  411 DGGV----SPLDRAYWEAEA-EDLAKQGLRVLAFAYREVDSEVEEID---HADLEGGLTFLGLQGMIDPPRPEAIAAVAE 482
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  697 CQRAGITVRMVTGDNINTARAIATKCGILHPGEdflCLEGKDFNRRIRNEKGEIEQERidkiwpklRVLARSSPTDKHTL 776
Cdd:cd02080  483 CQSAGIRVKMITGDHAETARAIGAQLGLGDGKK---VLTGAELDALDDEELAEAVDEV--------DVFARTSPEHKLRL 551
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  777 VKGIidstvsdQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISK 854
Cdd:cd02080  552 VRAL-------QARgeVVAMTGDGVNDAPALKQADIGIAMGIKGTEVAKEAADMVLADDNFATIAAAVEEGRRVYDNLKK 624
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  855 FLQFQLTVNV---VAVIVA-FTGACItqdsPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMK 930
Cdd:cd02080  625 FILFTLPTNLgegLVIIVAiLFGVTL----PLTPVQILWINMVTAITLGLALAFEPAEPGIMKRPPRDPSEPLLSRELIW 700
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  931 NILGHAFYQLVVVFTL-LFAGEKFFDIDSGRnaplhappsehyTIVFNTFVLMQLFNEINARKIHgeRNVFE-GIFNNAI 1008
Cdd:cd02080  701 RILLVSLLMLGGAFGLfLWALDRGYSLETAR------------TMAVNTIVVAQIFYLFNCRSLH--RSILKlGVFSNKI 766
                        970       980       990      1000
                 ....*....|....*....|....*....|....*....|.
gi 48255947 1009 FCTIVLGTFVVQIIIVQ-------FGGKPfscseLSIEQWL 1042
Cdd:cd02080  767 LFLGIGALILLQLAFTYlpfmnslFGTAP-----IDLVDWA 802
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
63-925 2.90e-128

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 417.46  E-value: 2.90e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   63 LKTSPNEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQppEGDNALcgevsv 142
Cdd:cd02083   12 FGVDPTRGLS--DEQVKRRREKYGPNELPAEEGKSLWELVLEQFDDLLVRILLLAAIISFVLALFE--EGEEGV------ 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  143 geeegegetgwiegaaillsvvcvvlvTAFND----------------WskekQFRGLQSRIEQEQKF-----TVIRGGQ 201
Cdd:cd02083   82 ---------------------------TAFVEpfvillilianavvgvW----QERNAEKAIEALKEYepemaKVLRNGK 130
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  202 VIQ-IPVADITVGDIAQVKYGDLLPADG--ILIQGNDLKIDESSLTGESDHVKKSLD--KDP---------LLLSGTHVM 267
Cdd:cd02083  131 GVQrIRARELVPGDIVEVAVGDKVPADIriIEIKSTTLRVDQSILTGESVSVIKHTDvvPDPravnqdkknMLFSGTNVA 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  268 EGSGRMVVTAVGVNsqTGIiftllgaggeeeekkdekkkekknkkqdGAIENrnkakaqdgaamEMQplKSEEggdgdek 347
Cdd:cd02083  211 AGKARGVVVGTGLN--TEI----------------------------GKIRD------------EMA--ETEE------- 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  348 dkkkanlpkkEKSVLQGKLTKLAVQIGKAgllmsaITVIILVLYFV-IDTF--WVQKRPWLAECtpIYiqyfvkFFIIGV 424
Cdd:cd02083  240 ----------EKTPLQQKLDEFGEQLSKV------ISVICVAVWAInIGHFndPAHGGSWIKGA--IY------YFKIAV 295
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  425 TVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYInekhYKKVPEPe 504
Cdd:cd02083  296 ALAVAAIPEGLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFI----LDKVEDD- 370
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  505 aipPNILSYLVTGISVNCA----YTSKILPPEKEGGLP-----------------------RHVGNKTECA--------- 548
Cdd:cd02083  371 ---SSLNEFEVTGSTYAPEgevfKNGKKVKAGQYDGLVelaticalcndssldyneskgvyEKVGEATETAltvlvekmn 447
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  549 --LLGLLLDLKRDYQDVRNEIPEEALYKVYT--FNSVRKSMStVL---KNSDGSYRIFSKGASEIILKKCFKILSANGEA 621
Cdd:cd02083  448 vfNTDKSGLSKRERANACNDVIEQLWKKEFTleFSRDRKSMS-VYcspTKASGGNKLFVKGAPEGVLERCTHVRVGGGKV 526
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  622 KVFRPRDRDDIVKTVIEpMASEGLRTICLAFRDFPAGEPEPEWDNENDIV---TGLTCIAVVGIEDPVRPEVPDAIKKCQ 698
Cdd:cd02083  527 VPLTAAIKILILKKVWG-YGTDTLRCLALATKDTPPKPEDMDLEDSTKFYkyeTDLTFVGVVGMLDPPRPEVRDSIEKCR 605
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  699 RAGITVRMVTGDNINTARAIATKCGILHPGEDFlclEGKDFNRRIRNEKGEIEQEridKIWPKLRVLARSSPTDKHTLVK 778
Cdd:cd02083  606 DAGIRVIVITGDNKGTAEAICRRIGIFGEDEDT---TGKSYTGREFDDLSPEEQR---EACRRARLFSRVEPSHKSKIVE 679
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  779 giidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIaGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQF 858
Cdd:cd02083  680 -----LLQSQGEITAMTGDGVNDAPALKKAEIGIAMGS-GTAVAKSASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRY 753
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 48255947  859 QLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLIS 925
Cdd:cd02083  754 LISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMKKPPRKPDEPLIS 820
P-type_ATPase_SPCA cd02085
golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory ...
196-1026 1.91e-121

golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p; SPCAs are Ca(2+) pumps important for the golgi-associated secretion pathway, in addition some function as Mn(2+) pumps in Mn(2+) detoxification. Saccharomyces cerevisiae Pmr1p is a high affinity Ca(2+)/Mn(2+) ATPase which transports Ca(2+) and Mn(2+) from the cytoplasm into the Golgi. Pmr1p also contributes to Cd(2+) detoxification. This subfamily includes human SPCA1 and SPCA2, encoded by the ATP2C1 and ATP2C2 genes; autosomal dominant Hailey-Hailey disease is caused by mutations in the human ATP2C1 gene. It also includes Strongylocentrotus purpuratus testis secretory pathway calcium transporting ATPase SPCA which plays an important role in fertilization. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319779 [Multi-domain]  Cd Length: 804  Bit Score: 394.07  E-value: 1.91e-121
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  196 VIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS---LDKDPL---------LLSG 263
Cdd:cd02085   88 CLRDGKLEHFLARELVPGDLVCLSIGDRIPADLRLFEATDLSIDESSLTGETEPCSKTtevIPKASNgdlttrsniAFMG 167
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  264 THVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaameMQplkSEEggd 343
Cdd:cd02085  168 TLVRCGHGKGIVIGTGENSEFGEVFKM------------------------------------------MQ---AEE--- 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  344 gdekdkkkanlpkKEKSVLQGKLTKLAVQigkagllMSAITVIILVLYFVIDtfWVQKRPWLaectpiyiqyfvKFFIIG 423
Cdd:cd02085  200 -------------APKTPLQKSMDKLGKQ-------LSLYSFIIIGVIMLIG--WLQGKNLL------------EMFTIG 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  424 VTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVvqayinekhykkvpep 503
Cdd:cd02085  246 VSLAVAAIPEGLPIVVTVTLALGVMRMAKRRAIVKKLPIVETLGCVNVICSDKTGTLTKNEMTV---------------- 309
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  504 eaippnilSYLVTGISVNCAYTSKILPPekegGLPRHvGNKTECALLGLLLDLKRDYQDVRnEIPeealykvytFNSVRK 583
Cdd:cd02085  310 --------TKIVTGCVCNNAVIRNNTLM----GQPTE-GALIALAMKMGLSDIRETYIRKQ-EIP---------FSSEQK 366
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  584 SMSTVLK---NSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIvKTVIEPMASEGLRTICLAfrdfpAGEp 660
Cdd:cd02085  367 WMAVKCIpkyNSDNEEIYFMKGALEQVLDYCTTYNSSDGSALPLTQQQRSEI-NEEEKEMGSKGLRVLALA-----SGP- 439
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  661 epewDNENDIVTGLtciavVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEdfLCLEGKdfn 740
Cdd:cd02085  440 ----ELGDLTFLGL-----VGINDPPRPGVREAIQILLESGVRVKMITGDAQETAIAIGSSLGLYSPSL--QALSGE--- 505
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  741 rrirnEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIIDSTvsdqrQVVAVTGDGTNDGPALKKADVGFAMGIAGTD 820
Cdd:cd02085  506 -----EVDQMSDSQLASVVRKVTVFYRASPRHKLKIVKALQKSG-----AVVAMTGDGVNDAVALKSADIGIAMGRTGTD 575
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  821 VAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASL 900
Cdd:cd02085  576 VCKEAADMILVDDDFSTILAAIEEGKGIFYNIKNFVRFQLSTSIAALSLIALSTLFNLPNPLNAMQILWINIIMDGPPAQ 655
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  901 ALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFyqLVVVFTL-LFAGEKFFDIDSGRNAplhappsehyTIVFNTF 979
Cdd:cd02085  656 SLGVEPVDKDVIRQPPRNVKDPILTRSLILNVLLSAA--IIVSGTLwVFWKEMSDDNVTPRDT----------TMTFTCF 723
                        810       820       830       840
                 ....*....|....*....|....*....|....*....|....*...
gi 48255947  980 VLMQLFNEINARkiHGERNVFE-GIFNNAIFCTIVLGTFVVQIIIVQF 1026
Cdd:cd02085  724 VFFDMFNALSCR--SQTKSIFEiGFFSNRMFLYAVGGSLIGQLLVIYF 769
ATPase-IIA1_Ca TIGR01116
sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the ...
195-990 5.65e-118

sarco/endoplasmic reticulum calcium-translocating P-type ATPase; This model describes the P-type ATPase responsible for translocating calcium ions across the endoplasmic reticulum membrane of eukaryotes, and is of particular importance in the sarcoplasmic reticulum of skeletal and cardiac muscle in vertebrates. These pumps transfer Ca2+ from the cytoplasm to the lumen of the endoplasmic reticulum. In humans and mice, at least, there are multiple isoforms of the SERCA pump with overlapping but not redundant functions. Defects in SERCA isoforms are associated with diseases in humans. The calcium P-type ATPases have been characterized as Type IIA based on a phylogenetic analysis which distinguishes this group from the Type IIB PMCA calcium pump modelled by TIGR01517. A separate analysis divides Type IIA into sub-types, SERCA and PMR1, the latter of which is modelled by TIGR01522. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273452 [Multi-domain]  Cd Length: 917  Bit Score: 387.99  E-value: 5.65e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSL-----------DKDPLLLSG 263
Cdd:TIGR01116   76 KVLRDGRWSVIKAKDLVPGDIVELAVGDKVPADIRVLSLKTLRVDQSILTGESVSVNKHTesvpderavnqDKKNMLFSG 155
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    264 THVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdekkkekknkkqdgaienrnkaKAQDGAAmemqplkseeggd 343
Cdd:TIGR01116  156 TLVVAGKARGVVVRTGMSTEIGKI------------------------------------RDEMRAA------------- 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    344 gdekdkkkanlpKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYF---VIDTFWVQKrpwlaectPIYiqyfvkFF 420
Cdd:TIGR01116  187 ------------EQEDTPLQKKLDEFGELLSKVIGLICILVWVINIGHFndpALGGGWIQG--------AIY------YF 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    421 IIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKV 500
Cdd:TIGR01116  241 KIAVALAVAAIPEGLPAVITTCLALGTRKMAKKNAIVRKLPSVETLGCTTVICSDKTGTLTTNQMSVCKVVALDPSSSSL 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    501 -----------PEPEAI----PPNILSY--LVTgISVNCAYT--SKILPPEKEGGLPRhVGNKTECA-----------LL 550
Cdd:TIGR01116  321 nefcvtgttyaPEGGVIkddgPVAGGQDagLEE-LATIAALCndSSLDFNERKGVYEK-VGEATEAAlkvlvekmglpAT 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    551 GLLLDLKRDYQDVRNEIPEEALYKVYT--FNSVRKSMStVLKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPRD 628
Cdd:TIGR01116  399 KNGVSSKRRPALGCNSVWNDKFKKLATleFSRDRKSMS-VLCKPSTGNKLFVKGAPEGVLERCTHILNGDGRAVPLTDKM 477
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    629 RDDIVkTVIEPMAS-EGLRTICLAFRDFPAGEPEPEWD---NENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITV 704
Cdd:TIGR01116  478 KNTIL-SVIKEMGTtKALRCLALAFKDIPDPREEDLLSdpaNFEAIESDLTFIGVVGMLDPPRPEVADAIEKCRTAGIRV 556
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    705 RMVTGDNINTARAIATKCGILHPGED--FLCLEGKDFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKgiid 782
Cdd:TIGR01116  557 IMITGDNKETAEAICRRIGIFSPDEDvtFKSFTGREFD--------EMGPAKQRAACRSAVLFSRVEPSHKSELVE---- 624
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    783 sTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTV 862
Cdd:TIGR01116  625 -LLQEQGEIVAMTGDGVNDAPALKKADIGIAMG-SGTEVAKEASDMVLADDNFATIVAAVEEGRAIYNNMKQFIRYMISS 702
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    863 NVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLIS-----RTMMKNILGHAF 937
Cdd:TIGR01116  703 NIGEVVCIFLTAALGIPEGLIPVQLLWVNLVTDGLPATALGFNPPDKDIMWKPPRRPDEPLITgwlffRYLVVGVYVGLA 782
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 48255947    938 YQLVVVFTLLFAGEKFFDIDSGRNAP--------LHAPPSEHYTIVFNTFVLMQLFNEINA 990
Cdd:TIGR01116  783 TVGGFVWWYLLTHFTGCDEDSFTTCPdfedpdcyVFEGKQPARTISLSVLVVIEMFNALNA 843
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
195-1023 1.47e-112

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 373.33  E-value: 1.47e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKS----LDKDP---------LLL 261
Cdd:cd02086   96 HVIRSGKTETISSKDVVPGDIVLLKVGDTVPADLRLIETKNFETDEALLTGESLPVIKDaelvFGKEEdvsvgdrlnLAY 175
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  262 SGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkKQDGAIENRNKAKaqdgaamemqplKSEEG 341
Cdd:cd02086  176 SSSTVTKGRAKGIVVATGMNTEIGKIAKAL--------------------RGKGGLISRDRVK------------SWLYG 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  342 GDGDEKDKKKANLPKKEKSVLQGKLTKLAVqigkagLLMsAITVIILVLYFVIDTFWVQKRpwlaectpiyiqyfvkFFI 421
Cdd:cd02086  224 TLIVTWDAVGRFLGTNVGTPLQRKLSKLAY------LLF-FIAVILAIIVFAVNKFDVDNE----------------VII 280
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  422 IGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYInekhykkvp 501
Cdd:cd02086  281 YAIALAISMIPESLVAVLTITMAVGAKRMVKRNVIVRKLDALEALGAVTDICSDKTGTLTQGKMVVRQVWI--------- 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  502 epeaipPNILSYLVTgisVNcaytskilppEKEGGLPRHV-GNKTECALLGLLLdlKRDYQDVRNEIPEEALYKV---YT 577
Cdd:cd02086  352 ------PAALCNIAT---VF----------KDEETDCWKAhGDPTEIALQVFAT--KFDMGKNALTKGGSAQFQHvaeFP 410
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  578 FNSVRKSMSTV-LKNSDGSYRIFSKGASEIILKKCFKILSANGEAKVFRPrDRDDIVKTViEPMASEGLRTICLAFRDFP 656
Cdd:cd02086  411 FDSTVKRMSVVyYNNQAGDYYAYMKGAVERVLECCSSMYGKDGIIPLDDE-FRKTIIKNV-ESLASQGLRVLAFASRSFT 488
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  657 A---GEPE---PEWDNEnDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGED 730
Cdd:cd02086  489 KaqfNDDQlknITLSRA-DAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKAIAREVGILPPNSY 567
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  731 FLCLEGKDFNRRIRNEKGEIEQERIDKIwPKL-RVLARSSPTDKhtlVKGIidSTVSDQRQVVAVTGDGTNDGPALKKAD 809
Cdd:cd02086  568 HYSQEIMDSMVMTASQFDGLSDEEVDAL-PVLpLVIARCSPQTK---VRMI--EALHRRKKFCAMTGDGVNDSPSLKMAD 641
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  810 VGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKA 884
Cdd:cd02086  642 VGIAMGLNGSDVAKDASDIVLTDDNFASIVNAIEEGRRMFDNIQKFVLHLLAENVAQVILLLIGLAFKDEDglsvfPLSP 721
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  885 VQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLV---VVFTLLFAGEKFFDIDSGRN 961
Cdd:cd02086  722 VEILWINMVTSSFPAMGLGLEKASPDVMQRPPHDLKVGIFTRELIIDTFVYGTFMGVlclASFTLVIYGIGNGDLGSDCN 801
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48255947  962 APLHAPPSEHY---TIVFNTFVLMQLF---NEINARK----IHGERNVFEGIF------NNAIFCTIVLGTFVVQIII 1023
Cdd:cd02086  802 ESYNSSCEDVFrarAAVFATLTWCALIlawEVVDMRRsffnMHPDTDSPVKSFfktlwkNKFLFWSVVLGFVSVFPTL 879
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
472-902 1.21e-95

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 308.23  E-value: 1.21e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  472 ICSDKTGTLTMNRMTVVQAYInekhykkvpepeaippnilsylvtgisvncaytskilppekegglprhvgnktecallg 551
Cdd:cd01431    2 ICSDKTGTLTKNGMTVTKLFI----------------------------------------------------------- 22
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  552 llldlkrdyqdvrneipeealyKVYTFNSVRKSMSTVLKNsDGSYRIFSKGASEIILKKCFKILSangeakvfrPRDRDD 631
Cdd:cd01431   23 ----------------------EEIPFNSTRKRMSVVVRL-PGRYRAIVKGAPETILSRCSHALT---------EEDRNK 70
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  632 IVKTVIEpMASEGLRTICLAFRDFPAGepepewDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDN 711
Cdd:cd01431   71 IEKAQEE-SAREGLRVLALAYREFDPE------TSKEAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDN 143
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  712 INTARAIATKCGILHPGEDFLCLEGKDfnrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKgiidstvSDQRQ- 790
Cdd:cd01431  144 PLTAIAIAREIGIDTKASGVILGEEAD----------EMSEEELLDLIAKVAVFARVTPEQKLRIVK-------ALQARg 206
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  791 -VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIV 869
Cdd:cd01431  207 eVVAMTGDGVNDAPALKQADVGIAMGSTGTDVAKEAADIVLLDDNFATIVEAVEEGRAIYDNIKKNITYLLANNVAEVFA 286
                        410       420       430
                 ....*....|....*....|....*....|...
gi 48255947  870 AFTGACITQDSPLKAVQMLWVNLIMDTLASLAL 902
Cdd:cd01431  287 IALALFLGGPLPLLAFQILWINLVTDLIPALAL 319
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
76-939 4.73e-89

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 301.67  E-value: 4.73e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   76 ADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSfyQPPEGdnalcgevsvgeeegegetgwie 155
Cdd:cd07538    5 AEARRRLESGGKNELPQPKKRTLLASILDVLREPMFLLLLAAALIYFVLG--DPREG----------------------- 59
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  156 gAAILLSVVCVVLVTAFNDWSKEKQFRGLqsRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGND 235
Cdd:cd07538   60 -LILLIFVVVIIAIEVVQEWRTERALEAL--KNLSSPRATVIRDGRERRIPSRELVPGDLLILGEGERIPADGRLLENDD 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  236 LKIDESSLTGESDHVKKSLD----------KDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdekk 305
Cdd:cd07538  137 LGVDESTLTGESVPVWKRIDgkamsapggwDKNFCYAGTLVVRGRGVAKVEATGSRTELGKI------------------ 198
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  306 kekknkkqdgaienrnkAKAQDGAAMEMQPLKSEeggdgdekdkkkanlpkkeksvlQGKLTKLavqIGKAGLLMSAITV 385
Cdd:cd07538  199 -----------------GKSLAEMDDEPTPLQKQ-----------------------TGRLVKL---CALAALVFCALIV 235
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  386 IilvLYFVIDTFWVQKrpwlaectpiyiqyfvkfFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACET 465
Cdd:cd07538  236 A---VYGVTRGDWIQA------------------ILAGITLAMAMIPEEFPVILTVFMAMGAWRLAKKNVLVRRAAAVET 294
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  466 MGNATAICSDKTGTLTMNRMTVvqayinekhykkvpepeaippnilsylvtgisvncaytskilppekegglprhvgnkt 545
Cdd:cd07538  295 LGSITVLCVDKTGTLTKNQMEV---------------------------------------------------------- 316
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  546 ecallgllldlkrdyQDVRNEIPEealykvYTFNSVRKSMSTVLKNSDGsYRIFSKGASEIILKKCfkilsangeakVFR 625
Cdd:cd07538  317 ---------------VELTSLVRE------YPLRPELRMMGQVWKRPEG-AFAAAKGSPEAIIRLC-----------RLN 363
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  626 PRDRDDIVKTVIEpMASEGLRTICLA-FRDFPAGEPEPEWDnendivTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITV 704
Cdd:cd07538  364 PDEKAAIEDAVSE-MAGEGLRVLAVAaCRIDESFLPDDLED------AVFIFVGLIGLADPLREDVPEAVRICCEAGIRV 436
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  705 RMVTGDNINTARAIATKCGILH-----PGEDFLCLEGKDFNRRIRNekgeieqeridkiwpkLRVLARSSPTDKHTLVKG 779
Cdd:cd07538  437 VMITGDNPATAKAIAKQIGLDNtdnviTGQELDAMSDEELAEKVRD----------------VNIFARVVPEQKLRIVQA 500
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  780 IidstvSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQ 859
Cdd:cd07538  501 F-----KANGEIVAMTGDGVNDAPALKAAHIGIAMGKRGTDVAREASDIVLLDDNFSSIVSTIRLGRRIYDNLKKAITYV 575
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  860 LTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISrtmmKNILGHAFYQ 939
Cdd:cd07538  576 FAIHVPIAGLALLPPLLGLPPLLFPVHVVLLELIIDPTCSIVFEAEPAERDIMRRPPRPPDEPLFG----PRLVIKAILQ 651
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
192-925 9.29e-89

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 306.97  E-value: 9.29e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  192 QKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLD---KDPL------LLS 262
Cdd:cd02608  106 QQALVIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISAHGCKVDNSSLTGESEPQTRSPEfthENPLetkniaFFS 185
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  263 gTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseegg 342
Cdd:cd02608  186 -TNCVEGTARGIVINTGDRTVMGRIATL---------------------------------------------------- 212
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  343 dgdekdkkkanlpkkeKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDtfWVQKRPWLAECtpiyiqyfvkFFII 422
Cdd:cd02608  213 ----------------ASGLEVGKTPIAREIEHFIHIITGVAVFLGVSFFILS--LILGYTWLEAV----------IFLI 264
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  423 GVtvlVVA-VPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTV---------VQAYI 492
Cdd:cd02608  265 GI---IVAnVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVahmwfdnqiHEADT 341
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  493 NE-----KHYKKVPEPEAippniLSYLVTGISvncayTSKILPPEKEGGLPRHV--GNKTECALLGLLLDLKRDYQDVRN 565
Cdd:cd02608  342 TEdqsgaSFDKSSATWLA-----LSRIAGLCN-----RAEFKAGQENVPILKRDvnGDASESALLKCIELSCGSVMEMRE 411
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  566 ------EIPeealykvytFNSVRKSMSTVLKNSDGS---YRIFSKGASEIILKKCFKILsANGEAKVFRPRDRDDIVKTV 636
Cdd:cd02608  412 rnpkvaEIP---------FNSTNKYQLSIHENEDPGdprYLLVMKGAPERILDRCSTIL-INGKEQPLDEEMKEAFQNAY 481
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  637 IEpMASEGLRTicLAFRD-------FPAGePEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTG 709
Cdd:cd02608  482 LE-LGGLGERV--LGFCHlylpddkFPEG-FKFDTDEVNFPTENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTG 557
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  710 DNINTARAIATKCGILhpgedflclegkdfnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIidstvsdQR 789
Cdd:cd02608  558 DHPITAKAIAKGVGII--------------------------------------VFARTSPQQKLIIVEGC-------QR 592
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  790 Q--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNvVAV 867
Cdd:cd02608  593 QgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSN-IPE 671
                        730       740       750       760       770       780
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48255947  868 IVAFTgACITQDSPLK--AVQMLWVNLIMDTLASLALATEPPTESLLLRKP----YGR--NKPLIS 925
Cdd:cd02608  672 ITPFL-IFIIANIPLPlgTITILCIDLGTDMVPAISLAYEKAESDIMKRQPrnpkTDKlvNERLIS 736
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
178-905 4.43e-87

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 295.48  E-value: 4.43e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  178 EKQFRGLqsRIEQEQKFTVIR--GGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLD 255
Cdd:cd07539   82 ERALAAL--LAQQQQPARVVRapAGRTQTVPAESLVPGDVIELRAGEVVPADARLLEADDLEVDESALTGESLPVDKQVA 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  256 KDP---------LLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLGaggeeeekkdekkkekknkkqdgaienrnkakaq 326
Cdd:cd07539  160 PTPgapladracMLYEGTTVVSGQGRAVVVATGPHTEAGRAQSLVA---------------------------------- 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  327 dgaamemqPLKSEEGgdgdekdkkkanlpkkeksvLQGKLTKLAVQIGKAGL-LMSAITVIILVLYFVIdtfwvqkRPWL 405
Cdd:cd07539  206 --------PVETATG--------------------VQAQLRELTSQLLPLSLgGGAAVTGLGLLRGAPL-------RQAV 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  406 AectpiyiqyfvkffiIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRM 485
Cdd:cd07539  251 A---------------DGVSLAVAAVPEGLPLVATLAQLAAARRLSRRGVLVRSPRTVEALGRVDTICFDKTGTLTENRL 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  486 TVVQAyinekhykkvpepeaippnilsylvtgisvncaytskilppekegglprhvgnktecallgllldlkrdyQDVRN 565
Cdd:cd07539  316 RVVQV----------------------------------------------------------------------RPPLA 325
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  566 EIPeealykvytFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILSAnGEAKVFRPRDRDDIVKtVIEPMASEGL 645
Cdd:cd07539  326 ELP---------FESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRCDRRMTG-GQVVPLTEADRQAIEE-VNELLAGQGL 394
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  646 RTICLAFRDFPAGEPEPEWDNENDivtgLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIL 725
Cdd:cd07539  395 RVLAVAYRTLDAGTTHAVEAVVDD----LELLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITARAIAKELGLP 470
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  726 HPGEdflCLEGKDFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVkgiidSTVSDQRQVVAVTGDGTNDGPAL 805
Cdd:cd07539  471 RDAE---VVTGAELDA--------LDEEALTGLVADIDVFARVSPEQKLQIV-----QALQAAGRVVAMTGDGANDAAAI 534
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  806 KKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAV 885
Cdd:cd07539  535 RAADVGIGVGARGSDAAREAADLVLTDDDLETLLDAVVEGRTMWQNVRDAVHVLLGGNLGEVMFTLIGTAIGGGAPLNTR 614
                        730       740
                 ....*....|....*....|
gi 48255947  886 QMLWVNLIMDTLASLALATE 905
Cdd:cd07539  615 QLLLVNLLTDMFPALALAVE 634
ATPase-IIC_X-K TIGR01106
sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This ...
192-954 1.42e-84

sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit; This model describes the P-type ATPases responsible for the exchange of either protons or sodium ions for potassium ions across the plasma membranes of eukaryotes. Unlike most other P-type ATPases, members of this subfamily require a beta subunit for activity. This model encompasses eukaryotes and consists of two functional types, a Na/K antiporter found widely distributed in eukaryotes and a H/K antiporter found only in vertebrates. The Na+ or H+/K+ antiporter P-type ATPases have been characterized as Type IIC based on a published phylogenetic analysis. Sequences from Blastocladiella emersonii (GP|6636502, GP|6636502 and PIR|T43025), C. elegans (GP|2315419, GP|6671808 and PIR|T31763) and Drosophila melanogaster (GP|7291424) score below trusted cutoff, apparently due to long branch length (excessive divergence from the last common ancestor) as evidenced by a phylogenetic tree. Experimental evidence is needed to determine whether these sequences represent ATPases with conserved function. Aside from fragments, other sequences between trusted and noise appear to be bacterial ATPases of unclear lineage, but most likely calcium pumps. [Energy metabolism, ATP-proton motive force interconversion]


Pssm-ID: 273445 [Multi-domain]  Cd Length: 997  Bit Score: 297.09  E-value: 1.42e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    192 QKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLD---KDPL-----LLSG 263
Cdd:TIGR01106  141 QQALVIRDGEKMSINAEQVVVGDLVEVKGGDRIPADLRIISAQGCKVDNSSLTGESEPQTRSPEfthENPLetrniAFFS 220
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    264 THVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggd 343
Cdd:TIGR01106  221 TNCVEGTARGIVVNTGDRTVMGRIASL----------------------------------------------------- 247
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    344 gdekdkkkanlpkkeKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTfwVQKRPWLAECtpiyiqyfvkFFIIG 423
Cdd:TIGR01106  248 ---------------ASGLENGKTPIAIEIEHFIHIITGVAVFLGVSFFILSL--ILGYTWLEAV----------IFLIG 300
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    424 VtvLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYI-NEKHYKKVPE 502
Cdd:TIGR01106  301 I--IVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFdNQIHEADTTE 378
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    503 PEA-IPPNILSYLVTGISVNCAYTSKILPPEKEGGLP---RHV-GNKTECALLGLLLDLKRDYQDVRN------EIPeea 571
Cdd:TIGR01106  379 DQSgVSFDKSSATWLALSRIAGLCNRAVFKAGQENVPilkRAVaGDASESALLKCIELCLGSVMEMRErnpkvvEIP--- 455
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    572 lykvytFNSVRKSMSTVLKNSDGS---YRIFSKGASEIILKKCFKILsANGEAKvfrPRDRD--DIVKTVIEPMASEGLR 646
Cdd:TIGR01106  456 ------FNSTNKYQLSIHENEDPRdprHLLVMKGAPERILERCSSIL-IHGKEQ---PLDEElkEAFQNAYLELGGLGER 525
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    647 TI--C---LAFRDFPAGEpEPEWDNENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATK 721
Cdd:TIGR01106  526 VLgfChlyLPDEQFPEGF-QFDTDDVNFPTDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKG 604
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    722 CGILHPG----EDF---LCLEGKDFNRRIRN-------EKGEIEQERIDKIwpkLR-----VLARSSPTDKHTLVKGIid 782
Cdd:TIGR01106  605 VGIISEGnetvEDIaarLNIPVSQVNPRDAKacvvhgsDLKDMTSEQLDEI---LKyhteiVFARTSPQQKLIIVEGC-- 679
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    783 stvsdQRQ--VVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQL 860
Cdd:TIGR01106  680 -----QRQgaIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL 754
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    861 TVNV--VAVIVAFTGACITQdsPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGR------NKPLISRTMMKNI 932
Cdd:TIGR01106  755 TSNIpeITPFLIFIIANIPL--PLGTITILCIDLGTDMVPAISLAYEKAESDIMKRQPRNPktdklvNERLISMAYGQIG 832
                          810       820
                   ....*....|....*....|..
gi 48255947    933 LGHAFYQLVVVFTLLfAGEKFF 954
Cdd:TIGR01106  833 MIQALGGFFTYFVIL-AENGFL 853
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
196-960 2.31e-80

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 285.75  E-value: 2.31e-80
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    196 VIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSL-------------DKDPLLLS 262
Cdd:TIGR01523  122 VIRNGKSDAIDSHDLVPGDICLLKTGDTIPADLRLIETKNFDTDEALLTGESLPVIKDAhatfgkeedtpigDRINLAFS 201
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    263 GTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkKQDGAIENRNKAKaqdgaamemQPLKSEEGG 342
Cdd:TIGR01523  202 SSAVTKGRAKGICIATALNSEIGAIAAGL--------------------QGDGGLFQRPEKD---------DPNKRRKLN 252
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    343 DGDEKDKKK---ANLPKKEKSVLQGKLTKLAVqigkaglLMSAITVIILVLYFVIDTFWVQKRpwlaecTPIYiqyfvkf 419
Cdd:TIGR01523  253 KWILKVTKKvtgAFLGLNVGTPLHRKLSKLAV-------ILFCIAIIFAIIVMAAHKFDVDKE------VAIY------- 312
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    420 fiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKK 499
Cdd:TIGR01523  313 ---AICLAISIIPESLIAVLSITMAMGAANMSKRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWIPRFGTIS 389
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    500 VP-EPEAIPPNILSylVTGISVNCAYTSK--------ILPPEK----EGGLPRHV------------------------- 541
Cdd:TIGR01523  390 IDnSDDAFNPNEGN--VSGIPRFSPYEYShneaadqdILKEFKdelkEIDLPEDIdmdlfiklletaalaniatvfkdda 467
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    542 -------GNKTECA-------------------LLGLLLDLKRDYQDVRNEIPEEALYKV---YTFNSVRKSMSTVLKNS 592
Cdd:TIGR01523  468 tdcwkahGDPTEIAihvfakkfdlphnaltgeeDLLKSNENDQSSLSQHNEKPGSAQFEFiaeFPFDSEIKRMASIYEDN 547
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    593 DG-SYRIFSKGASEIILKKCFkilSANGEAKV----FRPRDRDDIVKTViEPMASEGLRTICLAFRDFPAGEpepEWDNE 667
Cdd:TIGR01523  548 HGeTYNIYAKGAFERIIECCS---SSNGKDGVkispLEDCDRELIIANM-ESLAAEGLRVLAFASKSFDKAD---NNDDQ 620
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    668 NDIVT--------GLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIL--------HPGEDF 731
Cdd:TIGR01523  621 LKNETlnrataesDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKAIAQEVGIIppnfihdrDEIMDS 700
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    732 LCLEGKDFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHTLVKGIidstvSDQRQVVAVTGDGTNDGPALKKADVG 811
Cdd:TIGR01523  701 MVMTGSQFD--------ALSDEEVDDLKALCLVIARCAPQTKVKMIEAL-----HRRKAFCAMTGDGVNDSPSLKMANVG 767
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    812 FAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDS-----PLKAVQ 886
Cdd:TIGR01523  768 IAMGINGSDVAKDASDIVLSDDNFASILNAIEEGRRMFDNIMKFVLHLLAENVAEAILLIIGLAFRDENgksvfPLSPVE 847
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 48255947    887 MLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYqLVVVFTLLFAGeKFFDIDSGR 960
Cdd:TIGR01523  848 ILWCIMITSCFPAMGLGLEKAAPDLMDRLPHDNEVGIFQKELIIDMFAYGFF-LGGSCLASFTG-ILYGFGSGN 919
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
70-916 5.66e-71

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 253.32  E-value: 5.66e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   70 GLSGNPADlERREaVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNalcgevsvgeeegeg 149
Cdd:cd02077    1 GLTNEEAE-ERLE-KYGPNEISHEKFPSWFKLLLKAFINPFNIVLLVLALVSFFTDVLLAPGEFD--------------- 63
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  150 etgwIEGAAILLSVVCVVLVTAF-NDWSKEKQFRGLQSRIEQeqKFTVIRGGQVIQ-IPVADITVGDIAQVKYGDLLPAD 227
Cdd:cd02077   64 ----LVGALIILLMVLISGLLDFiQEIRSLKAAEKLKKMVKN--TATVIRDGSKYMeIPIDELVPGDIVYLSAGDMIPAD 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  228 GILIQGNDLKIDESSLTGESDHVKKS-----------LDKDPLLLSGTHVMEGSGRMVVTAVGVNsqtgiifTLLGAgge 296
Cdd:cd02077  138 VRIIQSKDLFVSQSSLTGESEPVEKHatakktkdesiLELENICFMGTNVVSGSALAVVIATGND-------TYFGS--- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  297 eeekkdekkkekknkkqdgaIENRNKakaqdgaamemqplkseeggdgdeKDKKKANLPKKEKSVlqgkltklavqigkA 376
Cdd:cd02077  208 --------------------IAKSIT------------------------EKRPETSFDKGINKV--------------S 229
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  377 GLLMSAITVIILVLYFVIDtfwVQKRPWLaectpiyiqyfvKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNL 456
Cdd:cd02077  230 KLLIRFMLVMVPVVFLING---LTKGDWL------------EALLFALAVAVGLTPEMLPMIVTSNLAKGAVRMSKRKVI 294
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  457 VRHLDACETMGNATAICSDKTGTLTMNRMTVVQAY-INEKHYKKVPEPEAIppNilSYLVTGIsvncaytskilppekEG 535
Cdd:cd02077  295 VKNLNAIQNFGAMDILCTDKTGTLTQDKIVLERHLdVNGKESERVLRLAYL--N--SYFQTGL---------------KN 355
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  536 GLPRHVGNKTEcalLGLLLDLKRDYQDVrNEIPeealykvytFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKIl 615
Cdd:cd02077  356 LLDKAIIDHAE---EANANGLIQDYTKI-DEIP---------FDFERRRMSVVVKDNDGKHLLITKGAVEEILNVCTHV- 421
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  616 SANGEAKVFRPRDRDDIVKTVIEpMASEGLRTICLAFRDFPAGEPEPEWDNENDivtgLTCIAVVGIEDPVRPEVPDAIK 695
Cdd:cd02077  422 EVNGEVVPLTDTLREKILAQVEE-LNREGLRVLAIAYKKLPAPEGEYSVKDEKE----LILIGFLAFLDPPKESAAQAIK 496
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  696 KCQRAGITVRMVTGDNINTARAIATKCGIlhPGEDflCLEGKDFNrrirnekgEIEQERIDKIWPKLRVLARSSPTDKHT 775
Cdd:cd02077  497 ALKKNGVNVKILTGDNEIVTKAICKQVGL--DINR--VLTGSEIE--------ALSDEELAKIVEETNIFAKLSPLQKAR 564
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  776 LVkgiidSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKF 855
Cdd:cd02077  565 II-----QALKKNGHVVGFMGDGINDAPALRQADVGISVDSA-VDIAKEAADIILLEKDLMVLEEGVIEGRKTFGNILKY 638
                        810       820       830       840       850       860
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 48255947  856 LQFQLTVN---VVAVIVAftgACITQDSPLKAVQMLWVNLIMDtLASLALATEPPTESlLLRKP 916
Cdd:cd02077  639 IKMTASSNfgnVFSVLVA---SAFLPFLPMLPIQLLLQNLLYD-FSQLAIPFDNVDEE-FLKKP 697
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
70-1018 2.71e-63

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 230.96  E-value: 2.71e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   70 GLSgnPADLERREAVFGKNFIPPKKP---KTFLQLVWEALQdvtlIILEIAAIVSLGLSFYQppegDNALcgevsvgeee 146
Cdd:cd02076    1 GLT--SEEAAKRLKEYGPNELPEKKEnpiLKFLSFFWGPIP----WMLEAAAILAAALGDWV----DFAI---------- 60
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  147 gegetgwiegaaillsVVCVVLVTAFNDWSKEKQFRGLQSRIEQ--EQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLL 224
Cdd:cd02076   61 ----------------ILLLLLINAGIGFIEERQAGNAVAALKKslAPKARVLRDGQWQEIDAKELVPGDIVSLKIGDIV 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  225 PADGILIQGNDLKIDESSLTGESDHVKKSldKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGiiftllgaggeeeekkdek 304
Cdd:cd02076  125 PADARLLTGDALQVDQSALTGESLPVTKH--PGDEAYSGSIVKQGEMLAVVTATGSNTFFG------------------- 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  305 kkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdkKKANLPKKEKSvlQGKLTKLAVQIGKAGLLMSAIT 384
Cdd:cd02076  184 ---------------------------------------------KTAALVASAEE--QGHLQKVLNKIGNFLILLALIL 216
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  385 V--IILVLYFVIDTFwvqkrpwlaectpIYIQYFVkffiigVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDA 462
Cdd:cd02076  217 VliIVIVALYRHDPF-------------LEILQFV------LVLLIASIPVAMPAVLTVTMAVGALELAKKKAIVSRLSA 277
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  463 CETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYK-----------KVPEPEAIPPNILSYLvtgisvncaytskilpp 531
Cdd:cd02076  278 IEELAGVDILCSDKTGTLTLNKLSLDEPYSLEGDGKdellllaalasDTENPDAIDTAILNAL----------------- 340
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  532 ekegglprhvgnktecallgllldlkRDYQDVRNEIPEEalyKVYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKC 611
Cdd:cd02076  341 --------------------------DDYKPDLAGYKQL---KFTPFDPVDKRTEATVEDPDGERFKVTKGAPQVILELV 391
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  612 FKilsangeakvfrPRDRDDIVKTVIEPMASEGLRTICLAfRDfpagEPEPEWDnendIVTGLTCIavvgieDPVRPEVP 691
Cdd:cd02076  392 GN------------DEAIRQAVEEKIDELASRGYRSLGVA-RK----EDGGRWE----LLGLLPLF------DPPRPDSK 444
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  692 DAIKKCQRAGITVRMVTGDNINTARAIATKCGI---LHPGEDFLCLEGKdfnrriRNEKGEIEQERIDkiwpKLRVLARS 768
Cdd:cd02076  445 ATIARAKELGVRVKMITGDQLAIAKETARQLGMgtnILSAERLKLGGGG------GGMPGSELIEFIE----DADGFAEV 514
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  769 SPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSIVKAVMWGRNV 848
Cdd:cd02076  515 FPEHKYRIVE-----ALQQRGHLVGMTGDGVNDAPALKKADVGIAVSGA-TDAARAAADIVLTAPGLSVIIDAIKTSRQI 588
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  849 YDSISKFLQFQLTVnVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEppteslllRKPYgRNKPLISRtm 928
Cdd:cd02076  589 FQRMKSYVIYRIAE-TLRILVFFTLGILILNFYPLPLIMIVLIAILNDGATLTIAYD--------NVPP-SPRPVRWN-- 656
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  929 MKNILGHAF----YQLVVVFTLLFAGEKFFDIDSGRNaplhaPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEG-I 1003
Cdd:cd02076  657 MPELLGIATvlgvVLTISSFLLLWLLDDQGWFEDIVL-----SAGELQTILYLQLSISGHLTIFVTRTRGPFWRPRPSpL 731
                        970
                 ....*....|....*
gi 48255947 1004 FNNAIFCTIVLGTFV 1018
Cdd:cd02076  732 LFIAVVLTQILATLL 746
P-type_ATPase cd02609
uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized ...
193-937 9.88e-61

uncharacterized subfamily of P-type ATPase transporter, similar to uncharacterized Streptococcus pneumoniae exported protein 7, Exp7; This subfamily contains P-type ATPase transporters of unknown function, similar to Streptococcus pneumoniae Exp7. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319795 [Multi-domain]  Cd Length: 661  Bit Score: 221.00  E-value: 9.88e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  193 KFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKslDKDPLLLSGTHVMEGSGR 272
Cdd:cd02609   93 KVTVIRDGQEVKIPPEELVLDDILILKPGEQIPADGEVVEGGGLEVDESLLTGESDLIPK--KAGDKLLSGSFVVSGAAY 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  273 MVVTAVGVNSQtgiiftllgaggeeeekkdekkkekknkkqdgaienrnkakaqdgAAMEMQPLKSEeggdgdekdkkka 352
Cdd:cd02609  171 ARVTAVGAESY---------------------------------------------AAKLTLEAKKH------------- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  353 nlpKKEKSVLQGKLTKLAVQIGKagLLMSAITVIILVLYFVIDTFWVQKrpwlaectpiyiqyfvkffIIG-VTVLVVAV 431
Cdd:cd02609  193 ---KLINSELLNSINKILKFTSF--IIIPLGLLLFVEALFRRGGGWRQA-------------------VVStVAALLGMI 248
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  432 PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYkkvpepEAIPPNIL 511
Cdd:cd02609  249 PEGLVLLTSVALAVGAIRLAKKKVLVQELYSIETLARVDVLCLDKTGTITEGKMKVERVEPLDEAN------EAEAAAAL 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  512 SYLVTGISVNCAyTSKILppekeggLPRHVGNktecallgllldlkrDYQDVRNEIPeealykvytFNSVRKsMSTVLKN 591
Cdd:cd02609  323 AAFVAASEDNNA-TMQAI-------RAAFFGN---------------NRFEVTSIIP---------FSSARK-WSAVEFR 369
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  592 SDGSYRIfskGASEIILkkcfkilsangeakvfrpRDRDDIVKTVIEPMASEGLRTICLAFrdfpagePEPEWDNENdIV 671
Cdd:cd02609  370 DGGTWVL---GAPEVLL------------------GDLPSEVLSRVNELAAQGYRVLLLAR-------SAGALTHEQ-LP 420
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  672 TGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGilhpgedflcLEGKDFNRRIRNEKGEIE 751
Cdd:cd02609  421 VGLEPLALILLTDPIRPEAKETLAYFAEQGVAVKVISGDNPVTVSAIAKRAG----------LEGAESYIDASTLTTDEE 490
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  752 QERIDKiwpKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 831
Cdd:cd02609  491 LAEAVE---NYTVFGRVTPEQKRQLVQ-----ALQALGHTVAMTGDGVNDVLALKEADCSIAMA-SGSDATRQVAQVVLL 561
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  832 DDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTESl 911
Cdd:cd02609  562 DSDFSALPDVVFEGRRVVNNIERVASLFLVKTIYSVLLALICVITALPFPFLPIQITLISLFTIGIPSFFLALEPNKRR- 640
                        730       740
                 ....*....|....*....|....*.
gi 48255947  912 llrkpygrnkplISRTMMKNILGHAF 937
Cdd:cd02609  641 ------------IEGGFLRRVLTKAL 654
ZntA COG2217
Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];
195-873 1.49e-51

Cation-transporting P-type ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 441819 [Multi-domain]  Cd Length: 717  Bit Score: 194.59  E-value: 1.49e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKSLDkDPLLlSGTHVMEGSGRMV 274
Cdd:COG2217  216 RVLRDGEEVEVPVEELRVGDRVLVRPGERIPVDGVVLEGESS-VDESMLTGESLPVEKTPG-DEVF-AGTINLDGSLRVR 292
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  275 VTAVGVNSQ-TGIIftllgaggeeeekkdekkkekknkkqdGAIENRNKAKAqdgaamemqplkseeggdgdekdkkkan 353
Cdd:COG2217  293 VTKVGSDTTlARII---------------------------RLVEEAQSSKA---------------------------- 317
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  354 lpkkeksvlqgKLTKLAVQIgkagllmSAI-TVIILVLYFVidTFWVqkrpWLaectpIYIQYFVKFFIIGVTVLVVAVP 432
Cdd:COG2217  318 -----------PIQRLADRI-------ARYfVPAVLAIAAL--TFLV----WL-----LFGGDFSTALYRAVAVLVIACP 368
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  433 EGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkVPEPEAIPPNILS 512
Cdd:COG2217  369 CALGLATPTAIMVGTGRAARRGILIKGGEALERLAKVDTVVFDKTGTLTEGKPEVTDV---------VPLDGLDEDELLA 439
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  513 Y-----------LVTGIsVNCAytskilpPEKEGGLPRHvgnktecallgllldlkrdyQDVRnEIP--------EEALY 573
Cdd:COG2217  440 LaaaleqgsehpLARAI-VAAA-------KERGLELPEV--------------------EDFE-AIPgkgveatvDGKRV 490
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  574 KVytfnsvrksmstvlknsdGSYRIFSKGASEIilkkcfkilsangeakvfrprdrDDIVKTVIEPMASEGLRTICLAfr 653
Cdd:COG2217  491 LV------------------GSPRLLEEEGIDL-----------------------PEALEERAEELEAEGKTVVYVA-- 527
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  654 dfpagepepeWDNEndivtgltCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflc 733
Cdd:COG2217  528 ----------VDGR--------LLGLIALADTLRPEAAEAIAALKALGIRVVMLTGDNERTAEAVARELGI--------- 580
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  734 legkdfnrrirnekgeieqeriDkiwpklRVLARSSPTDKHTLVKGIidstvSDQRQVVAVTGDGTNDGPALKKADVGFA 813
Cdd:COG2217  581 ----------------------D------EVRAEVLPEDKAAAVREL-----QAQGKKVAMVGDGINDAPALAAADVGIA 627
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  814 MGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:COG2217  628 MG-SGTDVAIEAADIVLMRDDLRGVPDAIRLSRATMRIIRQNLFWAFGYNVIGIPLAAGG 686
Cation_ATPase_C pfam00689
Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
880-1058 9.51e-49

Cation transporting ATPase, C-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport. This family represents 5 transmembrane helices.


Pssm-ID: 376368 [Multi-domain]  Cd Length: 175  Bit Score: 170.88  E-value: 9.51e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    880 SPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSG 959
Cdd:pfam00689    2 LPLTPIQILWINLVTDGLPALALGFEPPEPDLMKRPPRKPKEPLFSRKMLRRILLQGLLIAILTLLVFFLGLLGFGISES 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    960 RNAplhappsehYTIVFNTFVLMQLFNEINARKIHGERNVFeGIFNNAIFCTIVLGTFVVQIIIVQ--FGGKPFSCSELS 1037
Cdd:pfam00689   82 QNA---------QTMAFNTLVLSQLFNALNARSLRRSLFKI-GLFSNKLLLLAILLSLLLQLLIIYvpPLQAVFGTTPLS 151
                          170       180
                   ....*....|....*....|.
gi 48255947   1038 IEQWLWSIFLGMGTLLWGQLI 1058
Cdd:pfam00689  152 LEQWLIVLLLALVVLLVVELR 172
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
174-873 4.14e-47

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 179.33  E-value: 4.14e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  174 DWSKEKQFRGLQSRIEQEQKF-TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKK 252
Cdd:cd02079  106 ERARSRARSALKALLSLAPETaTVLEDGSTEEVPVDDLKVGDVVLVKPGERIPVDGVVVSGESS-VDESSLTGESLPVEK 184
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  253 SLDkDPLLlSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQDgaame 332
Cdd:cd02079  185 GAG-DTVF-AGTINLNGPLTIEVTKTGEDTTLAKIIRLV-------------------------------EEAQS----- 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  333 mqplkseeggdgdekdkkkanlpkkEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVqkrpWLAectpiy 412
Cdd:cd02079  227 -------------------------SKPPLQRLADRFARYFTPAVLVLAALVFLFWPLVGGPPSLAL----YRA------ 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  413 iqyfvkffiigVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYI 492
Cdd:cd02079  272 -----------LAVLVVACPCALGLATPTAIVAGIGRAARKGILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEIEP 340
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  493 nekhYKKVPEPEAIppNILSYLVTGIS-------VNcAYTSKILPPEKegglprhvgnktecallgllldlkrdYQDVRn 565
Cdd:cd02079  341 ----LEGFSEDELL--ALAAALEQHSEhplaraiVE-AAEEKGLPPLE--------------------------VEDVE- 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  566 EIPEEALYKVYtfnsvrksmstvlknSDGSYRIfskGASEIIlkkcfkilsangeakvfrprdRDDIVKTVIEPMASEGL 645
Cdd:cd02079  387 EIPGKGISGEV---------------DGREVLI---GSLSFA---------------------EEEGLVEAADALSDAGK 427
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  646 RTICLAFRDfpaGEPepewdnendivtgltcIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIL 725
Cdd:cd02079  428 TSAVYVGRD---GKL----------------VGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAVAKELGID 488
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  726 HpgedflclegkdfnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGiidstVSDQRQVVAVTGDGTNDGPAL 805
Cdd:cd02079  489 E-------------------------------------VHAGLLPEDKLAIVKA-----LQAEGGPVAMVGDGINDAPAL 526
                        650       660       670       680       690       700
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48255947  806 KKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:cd02079  527 AQADVGIAMG-SGTDVAIETADIVLLSNDLSKLPDAIRLARRTRRIIKQNLAWALGYNAIALPLAALG 593
ATPase-IB_hvy TIGR01525
heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the ...
174-873 1.05e-46

heavy metal translocating P-type ATPase; This model encompasses two equivalog models for the copper and cadmium-type heavy metal transporting P-type ATPases (TIGR01511 and TIGR01512) as well as those species which score ambiguously between both models. For more comments and references, see the files on TIGR01511 and 01512.


Pssm-ID: 273669 [Multi-domain]  Cd Length: 558  Bit Score: 177.05  E-value: 1.05e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    174 DWSKEKQFRGLQSRIEQ--EQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVK 251
Cdd:TIGR01525   36 ERAKSRASDALSALLALapSTARVLQGDGSEEEVPVEELQVGDIVIVRPGERIPVDGVVISGESE-VDESALTGESMPVE 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    252 KSldKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQdgaam 331
Cdd:TIGR01525  115 KK--EGDEVFAGTINGDGSLTIRVTKLGEDSTLAQIVELV-------------------------------EEAQ----- 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    332 emqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWVQKrpwlaectpi 411
Cdd:TIGR01525  157 -------------------------SSKAPIQRLADRIASYYVPAVLAIALLTFVVWLALGALWREALYR---------- 201
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    412 yiqyfvkffiiGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAy 491
Cdd:TIGR01525  202 -----------ALTVLVVACPCALGLATPVAILVAIGAAARRGILIKGGDALEKLAKVKTVVFDKTGTLTTGKPTVVDI- 269
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    492 inekhykkVPEPEAIPPNILsYLVTGIsvncaytskilppEKEGGLPRHVGNKTECALLGLLLDLKrdyqDVRnEIPEEA 571
Cdd:TIGR01525  270 --------EPLDDASEEELL-ALAAAL-------------EQSSSHPLARAIVRYAKERGLELPPE----DVE-EVPGKG 322
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    572 LykvytfnsvrksmstvlknsdgsyRIFSKGASEIILKKCFKIlsANGEAKVFRPRDRDDIVKTVIEpmaseGLRTICLA 651
Cdd:TIGR01525  323 V------------------------EATVDGGREVRIGNPRFL--GNRELAIEPISASPDLLNEGES-----QGKTVVFV 371
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    652 FRDfpagepepewdnenDIVTGltciaVVGIEDPVRPEVPDAIKKCQRAG-ITVRMVTGDNINTARAIATKCGIlhpged 730
Cdd:TIGR01525  372 AVD--------------GELLG-----VIALRDQLRPEAKEAIAALKRAGgIKLVMLTGDNRSAAEAVAAELGI------ 426
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    731 flclegkDFNrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKGIIDstvsdQRQVVAVTGDGTNDGPALKKADV 810
Cdd:TIGR01525  427 -------DDE-----------------------VHAELLPEDKLAIVKKLQE-----EGGPVAMVGDGINDAPALAAADV 471
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48255947    811 GFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:TIGR01525  472 GIAMG-SGSDVAIEAADIVLLNDDLRSLPTAIDLSRKTRRIIKQNLAWALGYNLVAIPLAAGG 533
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
195-842 5.01e-44

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 170.74  E-value: 5.01e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKSLDkDPLLlSGTHVMEGSGRMV 274
Cdd:cd02094  142 RVIRDGKEVEVPIEEVQVGDIVRVRPGEKIPVDGVVVEGESS-VDESMLTGESLPVEKKPG-DKVI-GGTINGNGSLLVR 218
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  275 VTAVGVNSQTGIIFTLlgaggeeeekkdekkkekknkkqdgaIEN--RNKAKAQdgaamemqplkseeggdgdekdkkka 352
Cdd:cd02094  219 ATRVGADTTLAQIIRL--------------------------VEEaqGSKAPIQ-------------------------- 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  353 nlpkkeksvlqgkltKLAVQIgkagllmSAI---TVIIL-VLYFVIdTFWVQKRPWLAECtpiyiqyfvkfFIIGVTVLV 428
Cdd:cd02094  247 ---------------RLADRV-------SGVfvpVVIAIaILTFLV-WLLLGPEPALTFA-----------LVAAVAVLV 292
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  429 VAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVqayinekhyKKVPEPEAIPP 508
Cdd:cd02094  293 IACPCALGLATPTAIMVGTGRAAELGILIKGGEALERAHKVDTVVFDKTGTLTEGKPEVT---------DVVPLPGDDED 363
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  509 NILSY-----------LVTGISVNCaytskilppeKEGGLPrhvgnktecallgllldlkrdyqdvrneipeeaLYKVYT 577
Cdd:cd02094  364 ELLRLaasleqgsehpLAKAIVAAA----------KEKGLE---------------------------------LPEVED 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  578 FNSVR-KSMSTVLknsdGSYRIFSkGASEIILKKCFKILSANGEAkvfrprdrddivktviEPMASEGLRTICLAFrdfp 656
Cdd:cd02094  401 FEAIPgKGVRGTV----DGRRVLV-GNRRLMEENGIDLSALEAEA----------------LALEEEGKTVVLVAV---- 455
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  657 agepepewDNEndivtgltCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHpgedflcleg 736
Cdd:cd02094  456 --------DGE--------LAGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARAIAKELGIDE---------- 509
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  737 kdfnrrirnekgeieqeridkiwpklrVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGi 816
Cdd:cd02094  510 ---------------------------VIAEVLPEDKAEKVK-----KLQAQGKKVAMVGDGINDAPALAQADVGIAIG- 556
                        650       660
                 ....*....|....*....|....*.
gi 48255947  817 AGTDVAKEASDIILTDDNFTSIVKAV 842
Cdd:cd02094  557 SGTDVAIESADIVLMRGDLRGVVTAI 582
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
195-870 1.18e-42

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 169.09  E-value: 1.18e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   195 TVIRGGQV------IQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKK-----------SLDKD 257
Cdd:PRK10517  162 TVLRVINDkgengwLEIPIDQLVPGDIIKLAAGDMIPADLRILQARDLFVAQASLTGESLPVEKfattrqpehsnPLECD 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   258 PLLLSGTHVMEGSGRMVVTAVGVNSQtgiiFtllgaggeeeekkdekkkekknkkqdGAIENRnkAKAQDGAAMEMQplk 337
Cdd:PRK10517  242 TLCFMGTNVVSGTAQAVVIATGANTW----F--------------------------GQLAGR--VSEQDSEPNAFQ--- 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   338 seeggdgdekdkkkanlpkkeksvlQGkltklavqIGKAGLLMSAITVIILVLYFVIDTFwvQKRPWlaectpiyiqyfV 417
Cdd:PRK10517  287 -------------------------QG--------ISRVSWLLIRFMLVMAPVVLLINGY--TKGDW------------W 319
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   418 KFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRM------------ 485
Cdd:PRK10517  320 EAALFALSVAVGLTPEMLPMIVTSTLARGAVKLSKQKVIVKRLDAIQNFGAMDILCTDKTGTLTQDKIvlenhtdisgkt 399
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   486 ---TVVQAYINekhykkvpepeaippnilSYLVTGIsvncaytsKILppekeggLPRHVgnkTECALLGLLLDLKRDYQD 562
Cdd:PRK10517  400 serVLHSAWLN------------------SHYQTGL--------KNL-------LDTAV---LEGVDEESARSLASRWQK 443
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   563 VrNEIPeealykvytFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKIlSANGEAKVFRPRDRDDIvKTVIEPMAS 642
Cdd:PRK10517  444 I-DEIP---------FDFERRRMSVVVAENTEHHQLICKGALEEILNVCSQV-RHNGEIVPLDDIMLRRI-KRVTDTLNR 511
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   643 EGLRTICLAFRDFPAGEPEPEWDNENDivtgLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKC 722
Cdd:PRK10517  512 QGLRVVAVATKYLPAREGDYQRADESD----LILEGYIAFLDPPKETTAPALKALKASGVTVKILTGDSELVAAKVCHEV 587
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   723 GILHPGedflCLEGKDFNRrirnekgeIEQERIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDG 802
Cdd:PRK10517  588 GLDAGE----VLIGSDIET--------LSDDELANLAERTTLFARLTPMHKERIVT-----LLKREGHVVGFMGDGINDA 650
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48255947   803 PALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----NVVAVIVA 870
Cdd:PRK10517  651 PALRAADIGISVD-GAVDIAREAADIILLEKSLMVLEEGVIEGRRTFANMLKYI--KMTAssnfgNVFSVLVA 720
ATPase-IB2_Cd TIGR01512
heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ...
171-873 4.56e-41

heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating cadmium ions (and other closely-related divalent heavy metals such as cobalt, mercury, lead and zinc) across biological membranes. These transporters are found in prokaryotes and plants. Experimentally characterized members of the seed alignment include: SP|P37617 from E. coli, SP|Q10866 from Mycobacterium tuberculosis and SP|Q59998 from Synechocystis PCC6803. The cadmium P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the copper-ATPases (TIGR01511) are well separated, and thus we further type the copper-ATPases as IB1 and the cadmium-ATPases as IB2. Several sequences which have not been characterized experimentally fall just below trusted cutoff for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273665 [Multi-domain]  Cd Length: 550  Bit Score: 160.18  E-value: 4.56e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    171 AFNDWSKEKQFRGLQSRIEQE-QKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDH 249
Cdd:TIGR01512   33 TLEEYASGRARRALKALMELApDTARRLQGDSLEEVAVEELKVGDVVVVKPGERVPVDGEVLSGTSS-VDESALTGESVP 111
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    250 VKKSLDKDplLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQdga 329
Cdd:TIGR01512  112 VEKAPGDE--VFAGAINLDGVLTIEVTKLPADSTIAKIVNLV-------------------------------EEAQ--- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    330 amemqplkseeggdgdekdkkkanlpkKEKSVLQGKLTKLAVQigkaglLMSAITVIILVLYFVidtFWVQKRPWLAEct 409
Cdd:TIGR01512  156 ---------------------------SRKAPTQRFIDRFARY------YTPAVLAIALAAALV---PPLLGAGPFLE-- 197
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    410 piyiqyfvkFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQ 489
Cdd:TIGR01512  198 ---------WIYRALVLLVVASPCALVISAPAAYLSAISAAARHGILIKGGAALEALAKIKTVAFDKTGTLTTGKPKVTD 268
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    490 AyinekhykkVPEPEAIPPNILSYL---------VTGISVNCAYTSKILPPEKEgglprhvgnktecallgllldlkrdy 560
Cdd:TIGR01512  269 V---------HPADGHSESEVLRLAaaaeqgsthPLARAIVDYARARELAPPVE-------------------------- 313
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    561 qDVRnEIPEEALYKVYtfnsvrksmstvlknsdgsyrifskgaseiilkkcfkilsANGEAKVFRPRDRDDIVKTVIEPM 640
Cdd:TIGR01512  314 -DVE-EVPGEGVRAVV----------------------------------------DGGEVRIGNPRSLSEAVGASIAVP 351
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    641 ASEGlRTICLAFRDfpagepepewdnenDIVTGLtciavVGIEDPVRPEVPDAIKKCQRAGI-TVRMVTGDNINTARAIA 719
Cdd:TIGR01512  352 ESAG-KTIVLVARD--------------GTLLGY-----IALSDELRPDAAEAIAELKALGIkRLVMLTGDRRAVAEAVA 411
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    720 TKCGILhpgedflclegkdfnrrirnekgeieqeridkiwpklRVLARSSPTDKHTLVKGIIDstvsdQRQVVAVTGDGT 799
Cdd:TIGR01512  412 RELGID-------------------------------------EVHAELLPEDKLEIVKELRE-----KAGPVAMVGDGI 449
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 48255947    800 NDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:TIGR01512  450 NDAPALAAADVGIAMGASGSDVALETADVVLLNDDLSRLPQAIRLARRTRRIIKQNVVIALGIILVLILLALFG 523
ATPase-IB1_Cu TIGR01511
copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase ...
199-870 4.79e-38

copper-(or silver)-translocating P-type ATPase; This model describes the P-type ATPase primarily responsible for translocating copper ions accross biological membranes. These transporters are found in prokaryotes and eukaryotes. This model encompasses those species which pump copper ions out of cells or organelles (efflux pumps such as CopA of Escherichia coli) as well as those which pump the ion into cells or organelles either for the purpose of supporting life in extremely low-copper environments (for example CopA of Enterococcus hirae) or for the specific delivery of copper to a biological complex for which it is a necessary component (for example FixI of Bradyrhizobium japonicum, or CtaA and PacS of Synechocystis). The substrate specificity of these transporters may, to a varying degree, include silver ions (for example, CopA from Archaeoglobus fulgidus). Copper transporters from this family are well known as the genes which are mutated in two human disorders of copper metabolism, Wilson's and Menkes' diseases. The sequences contributing to the seed of this model are all experimentally characterized. The copper P-type ATPases have been characterized as Type IB based on a phylogenetic analysis which combines the copper-translocating ATPases with the cadmium-translocating species. This model and that describing the cadmium-ATPases (TIGR01512) are well separated, and thus we further type the copper-ATPases as IB1 (and the cadmium-ATPases as IB2). Several sequences which have not been characterized experimentally fall just below the cutoffs for both of these models (SP|Q9CCL1 from Mycobacterium leprae, GP|13816263 from Sulfolobus solfataricus, OMNI|NTL01CJ01098 from Campylobacter jejuni, OMNI|NTL01HS01687 from Halobacterium sp., GP|6899169 from Ureaplasma urealyticum and OMNI|HP1503 from Helicobacter pylori). Accession PIR|A29576 from Enterococcus faecalis scores very high against this model, but yet is annotated as an "H+/K+ exchanging ATPase". BLAST of this sequence does not hit anything else annotated in this way. This error may come from the characterization paper published in 1987. Accession GP|7415611 from Saccharomyces cerevisiae appears to be mis-annotated as a cadmium resistance protein. Accession OMNI|NTL01HS00542 from Halobacterium which scores above trusted for this model is annotated as "molybdenum-binding protein" although no evidence can be found for this classification. [Cellular processes, Detoxification, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273664 [Multi-domain]  Cd Length: 562  Bit Score: 151.27  E-value: 4.79e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    199 GGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDlKIDESSLTGESDHVKKSLDkDPLLlSGTHVMEGSGRMVVTAV 278
Cdd:TIGR01511   99 DGSIEEVPVALLQPGDIVKVLPGEKIPVDGTVIEGES-EVDESLVTGESLPVPKKVG-DPVI-AGTVNGTGSLVVRATAT 175
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    279 GVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQdgaamemqplkseeggdgdekdkkkanlpkKE 358
Cdd:TIGR01511  176 GEDTTLAQIVRLV-------------------------------RQAQ------------------------------QS 194
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    359 KSVLQGkltkLAVQIgkAGLLMSAItVIILVLYFVIdtfWVQKrpwlaectpiyiqyfvkfFIIGVTVLVVAVPEGLPLA 438
Cdd:TIGR01511  195 KAPIQR----LADKV--AGYFVPVV-IAIALITFVI---WLFA------------------LEFAVTVLIIACPCALGLA 246
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    439 VTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkVPEPEAIPPNILSYLvtgi 518
Cdd:TIGR01511  247 TPTVIAVATGLAAKNGVLIKDGDALERAANIDTVVFDKTGTLTQGKPTVTDV---------HVFGDRDRTELLALA---- 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    519 svncaytskilppekeGGLPRHVGNKTECAllgllldlkrdyqdVRNEIpEEALYKVYTFNSVRKsmstvlknsdgsyrI 598
Cdd:TIGR01511  314 ----------------AALEAGSEHPLAKA--------------IVSYA-KEKGITLVTVSDFKA--------------I 348
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    599 FSKGASEIILKKCFKIlsanGEAKVFRPrdrddivKTVIEPMASEGLRTICLAFRDFPAgepepewdnendivtgltcIA 678
Cdd:TIGR01511  349 PGIGVEGTVEGTKIQL----GNEKLLGE-------NAIKIDGKAGQGSTVVLVAVNGEL-------------------AG 398
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    679 VVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflclegkdfnrrirnekgeieqeridki 758
Cdd:TIGR01511  399 VFALEDQLRPEAKEVIQALKRRGIEPVMLTGDNRKTAKAVAKELGI---------------------------------- 444
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    759 wpklRVLARSSPTDKHTLVKGIidstvSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSI 838
Cdd:TIGR01511  445 ----DVRAEVLPDDKAALIKKL-----QEKGPVVAMVGDGINDAPALAQADVGIAIG-AGTDVAIEAADVVLLRNDLNDV 514
                          650       660       670
                   ....*....|....*....|....*....|..
gi 48255947    839 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 870
Cdd:TIGR01511  515 ATAIDLSRKTLRRIKQNLLWAFGYNVIAIPIA 546
P-type_ATPase_Cu-like cd07552
P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+) ...
196-870 1.61e-35

P-type heavy metal-transporting ATPase, similar to Archaeoglobus fulgidus CopB, a Cu(2+)-ATPase; Archaeoglobus fulgidus CopB transports Cu(2+) from the cytoplasm to the exterior of the cell using ATP as energy source, it transports preferentially Cu(2+) over Cu(+), it is activated by Cu(2+) with high affinity and partially by Cu(+) and Ag(+). This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319850 [Multi-domain]  Cd Length: 632  Bit Score: 144.37  E-value: 1.61e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  196 VIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESdhvkKSLDKDP--LLLSGTHVMEGSGRM 273
Cdd:cd07552  135 LVTDGSIEDVPVSELKVGDVVLVRAGEKIPADGTILEGESS-VNESMVTGES----KPVEKKPgdEVIGGSVNGNGTLEV 209
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  274 VVTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQdgaamemqplkseeggdgdekdkkkan 353
Cdd:cd07552  210 KVTKTGEDSYLSQVMELV-------------------------------AQAQ--------------------------- 231
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  354 lpkKEKSvlqgKLTKLAVQIgkAGLLMSaITVIILVLYFVIdtfwvqkrpWLaectpiYIQYFVKFFIIGVTVLVVAVPE 433
Cdd:cd07552  232 ---ASKS----RAENLADKV--AGWLFY-IALGVGIIAFII---------WL------ILGDLAFALERAVTVLVIACPH 286
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  434 GL----PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKvpepeaippN 509
Cdd:cd07552  287 ALglaiPLVVARSTSIAAKNGL----LIRNREALERARDIDVVLFDKTGTLTEGKFGVTDVITFDEYDED---------E 353
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  510 ILSY-----------LVTGIsVNCAYTSKILPPEKEG-------GLPRHVGNKtecallgllldlkrDYQDVRNEIPEEA 571
Cdd:cd07552  354 ILSLaaaleagsehpLAQAI-VSAAKEKGIRPVEVENfenipgvGVEGTVNGK--------------RYQVVSPKYLKEL 418
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  572 LYKVYTfnsvrksmstvlknsdgsyrifskgasEIilkkcFKILSANGEAKVFRPRDRDdivktviepmaseglrticla 651
Cdd:cd07552  419 GLKYDE---------------------------EL-----VKRLAQQGNTVSFLIQDGE--------------------- 445
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  652 frdfpagepepewdnendivtgltCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILhpgedf 731
Cdd:cd07552  446 ------------------------VIGAIALGDEIKPESKEAIRALKAQGITPVMLTGDNEEVAQAVAEELGID------ 495
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  732 lclegkdfnrrirnekgeieqeridkiwpklRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVG 811
Cdd:cd07552  496 -------------------------------EYFAEVLPEDKAKKVK-----ELQAEGKKVAMVGDGVNDAPALAQADVG 539
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 48255947  812 FAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVA 870
Cdd:cd07552  540 IAIG-AGTDVAIESADVVLVKSDPRDIVDFLELAKATYRKMKQNLWWGAGYNVIAIPLA 597
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
171-944 2.71e-34

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 142.31  E-value: 2.71e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  171 AFNDWSKEKQFRGLQSRieqeqKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLK----IDESSLTGE 246
Cdd:cd02073   67 GYEDIRRHKSDNEVNNR-----PVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDglcyVETANLDGE 141
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  247 SDH-VKKSLDKDPLLLSGTHVMEGSGRMVV--------TAVGVNSQTGIIFTLLGaggeeeekkdekkkekknkkqdgaI 317
Cdd:cd02073  142 TNLkIRQALPETALLLSEEDLARFSGEIECeqpnndlyTFNGTLELNGGRELPLS------------------------P 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  318 EN--------RNKAKAQdGAAmemqplkseeggdgdekdkkkanlpkkeksVLQGKLTKLAVQIGKAGLLMSAITVII-- 387
Cdd:cd02073  198 DNlllrgctlRNTEWVY-GVV------------------------------VYTGHETKLMLNSGGTPLKRSSIEKKMnr 246
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  388 -LVLYFVI-----------DTFWV----QKRPWLAECTPI--YIQYFVKF--FIIgvtVLVVAVPegLPLAVTISLAYSV 447
Cdd:cd02073  247 fIIAIFCIlivmclisaigKGIWLskhgRDLWYLLPKEERspALEFFFDFltFII---LYNNLIP--ISLYVTIEVVKFL 321
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  448 --------KKMMKDNN----LVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHY--------------KKVP 501
Cdd:cd02073  322 qsffinwdLDMYDEETdtpaEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDYgfflalalchtvvpEKDD 401
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  502 EP-----EAIPPNILSyLVTGI-SVNCAYTSKilppekegglprhvgnktecallglllDLKRDYQDVRNEIPEEALYKV 575
Cdd:cd02073  402 HPgqlvyQASSPDEAA-LVEAArDLGFVFLSR---------------------------TPDTVTINALGEEEEYEILHI 453
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  576 YTFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCfkilsANGEAKVFRPrdrddiVKTVIEPMASEGLRTICLAFRDF 655
Cdd:cd02073  454 LEFNSDRKRMSVIVRDPDGRILLYCKGADSVIFERL-----SPSSLELVEK------TQEHLEDFASEGLRTLCLAYREI 522
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  656 PAGEPEpEWDNE-------------------NDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTAR 716
Cdd:cd02073  523 SEEEYE-EWNEKydeastalqnreelldevaEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDKQETAI 601
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  717 AIATKCGILHPG-EDF-LCLEGKDFNrrirnekgEIEQERIDKIWPKLRVLA------RSSPTDKHTLVKGIIDSTvsdq 788
Cdd:cd02073  602 NIGYSCRLLSEDmENLaLVIDGKTLT--------YALDPELERLFLELALKCkaviccRVSPLQKALVVKLVKKSK---- 669
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  789 RQVVAVTGDGTNDGPALKKADVGfaMGIAGtdvaKE------ASDIILTddNFTSIVKAVM-WGRNVYDSISKFLQFQLT 861
Cdd:cd02073  670 KAVTLAIGDGANDVSMIQEAHVG--VGISG----QEgmqaarASDYAIA--QFRFLRRLLLvHGRWSYQRLAKLILYFFY 741
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  862 VNVVAVIV-----AFTGAciTQDSPLKAVQMLWVNLIMDTLASLALAT--EPPTESLLLRKP----YGRNKPLIS-RTMM 929
Cdd:cd02073  742 KNIAFYLTqfwyqFFNGF--SGQTLYDSWYLTLYNVLFTSLPPLVIGIfdQDVSAETLLRYPelykPGQLNELFNwKVFL 819
                        890
                 ....*....|....*
gi 48255947  930 KNILgHAFYQLVVVF 944
Cdd:cd02073  820 YWIL-DGIYQSLIIF 833
E1-E2_ATPase pfam00122
E1-E2 ATPase;
195-452 4.38e-32

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 123.45  E-value: 4.38e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKslDKDPLLLSGTHVMEGSGRMV 274
Cdd:pfam00122    8 TVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVEGSAS-VDESLLTGESLPVEK--KKGDMVYSGTVVVSGSAKAV 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    275 VTAVGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdkkkaNL 354
Cdd:pfam00122   85 VTATGEDTELGRIARLV-------------------------------------------------------------EE 103
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    355 PKKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFWvqkrpwlaectpiyiqyfvkfFIIGVTVLVVAVPEG 434
Cdd:pfam00122  104 AKSKKTPLQRLLDRLGKYFSPVVLLIALAVFLLWLFVGGPPLRA---------------------LLRALAVLVAACPCA 162
                          250
                   ....*....|....*...
gi 48255947    435 LPLAVTISLAYSVKKMMK 452
Cdd:pfam00122  163 LPLATPLALAVGARRLAK 180
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
195-929 7.30e-32

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 134.77  E-value: 7.30e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   195 TVIR------GGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKK---------------S 253
Cdd:PRK15122  151 TVLRrghagaEPVRREIPMRELVPGDIVHLSAGDMIPADVRLIESRDLFISQAVLTGEALPVEKydtlgavagksadalA 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   254 LDKDPLL------LSGTHVMEGSGRMVVTAVGVNSQTGIIftllgaggeeeekkdekkkekknkkqdgaienrnkAKAqd 327
Cdd:PRK15122  231 DDEGSLLdlpnicFMGTNVVSGTATAVVVATGSRTYFGSL-----------------------------------AKS-- 273
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   328 gaamemqplkseeggdgdekdkkkanlpkkeksvLQGKLTKLAVQIGKAG---LLMSAITVIILVLyFVIDTFwvQKRPW 404
Cdd:PRK15122  274 ----------------------------------IVGTRAQTAFDRGVNSvswLLIRFMLVMVPVV-LLINGF--TKGDW 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   405 LAECTpiyiqyfvkfFiigvtVLVVAV---PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLT 481
Cdd:PRK15122  317 LEALL----------F-----ALAVAVgltPEMLPMIVSSNLAKGAIAMARRKVVVKRLNAIQNFGAMDVLCTDKTGTLT 381
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   482 MNRMtvvqayINEKHYKKVPEPEaipPNIL------SYLVTGIsvncaytsKILppekeggLPRHVgnkTECALLGLLLD 555
Cdd:PRK15122  382 QDRI------ILEHHLDVSGRKD---ERVLqlawlnSFHQSGM--------KNL-------MDQAV---VAFAEGNPEIV 434
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   556 LKRDYQDVrNEIPeealykvytFNSVRKSMSTVLKNSDGSYRIFSKGASEIILKKCFKILsangEAKVFRPRD--RDDIV 633
Cdd:PRK15122  435 KPAGYRKV-DELP---------FDFVRRRLSVVVEDAQGQHLLICKGAVEEMLAVATHVR----DGDTVRPLDeaRRERL 500
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   634 KTVIEPMASEGLRTICLAFRDFPAGEPEPEW--DNEND-IVTG-LTCIavvgieDPVRPEVPDAIKKCQRAGITVRMVTG 709
Cdd:PRK15122  501 LALAEAYNADGFRVLLVATREIPGGESRAQYstADERDlVIRGfLTFL------DPPKESAAPAIAALRENGVAVKVLTG 574
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   710 DN-INTARaIATKCGiLHPGEDflcLEGKDFNRRIRNEKGEIEQERIdkiwpklrVLARSSPTDKHTLVKgiidsTVSDQ 788
Cdd:PRK15122  575 DNpIVTAK-ICREVG-LEPGEP---LLGTEIEAMDDAALAREVEERT--------VFAKLTPLQKSRVLK-----ALQAN 636
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   789 RQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLqfQLTV-----N 863
Cdd:PRK15122  637 GHTVGFLGDGINDAPALRDADVGISVD-SGADIAKESADIILLEKSLMVLEEGVIKGRETFGNIIKYL--NMTAssnfgN 713
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 48255947   864 VVAVIVAftGACITQdSPLKAVQMLWVNLIMDtLASLALatepPTESL---LLRKPYGRNKPLISRTMM 929
Cdd:PRK15122  714 VFSVLVA--SAFIPF-LPMLAIHLLLQNLMYD-ISQLSL----PWDKMdkeFLRKPRKWDAKNIGRFML 774
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
171-1071 1.62e-30

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 130.58  E-value: 1.62e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    171 AFNDWSkekqfRGLQSRIEQEQKFTVIRG-GQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLK----IDESSLTG 245
Cdd:TIGR01652   69 AIEDIR-----RRRRDKEVNNRLTEVLEGhGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDgvcyVETANLDG 143
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    246 ESD-HVKKSLDKDPLLLSGTHVMEGSGRmvVTAVGVNSQtgiIFTLLGaggeeeekkdekkkekkNKKQDGAienRNKAK 324
Cdd:TIGR01652  144 ETNlKLRQALEETQKMLDEDDIKNFSGE--IECEQPNAS---LYSFQG-----------------NMTINGD---RQYPL 198
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    325 AQDGAAMEMQPLKSEE---------GGDgdEKDKKKANLPKKEKSVLQGKLTKLAVQIgkAGLLMsaITVIILVLYFVID 395
Cdd:TIGR01652  199 SPDNILLRGCTLRNTDwvigvvvytGHD--TKLMRNATQAPSKRSRLEKELNFLIIIL--FCLLF--VLCLISSVGAGIW 272
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    396 TFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVV---AVPegLPLAVTISLAYSVKKMMKDNNL------------VRHL 460
Cdd:TIGR01652  273 NDAHGKDLWYIRLDVSERNAAANGFFSFLTFLILfssLIP--ISLYVSLELVKSVQAYFINSDLqmyhektdtpasVRTS 350
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    461 DACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHY-KKVPEPEAIPPNILsylvtGISVNCAYTSKILPPEKEGGLPR 539
Cdd:TIGR01652  351 NLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYgDGFTEIKDGIRERL-----GSYVENENSMLVESKGFTFVDPR 425
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    540 HVGN------KTECA---------------LLGLLLDLKRDYQdvrNEIP-EEALYK----------------------- 574
Cdd:TIGR01652  426 LVDLlktnkpNAKRInefflalalchtvvpEFNDDGPEEITYQ---AASPdEAALVKaardvgfvffertpksislliem 502
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    575 -----------VYTFNSVRKSMSTVLKNSDGSYRIFSKGASEIIlkkcFKILSANGEAKVfrprdrdDIVKTVIEPMASE 643
Cdd:TIGR01652  503 hgetkeyeilnVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVI----FKRLSSGGNQVN-------EETKEHLENYASE 571
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    644 GLRTICLAFRDFPAGEPEpEWDNEND-------------------IVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITV 704
Cdd:TIGR01652  572 GLRTLCIAYRELSEEEYE-EWNEEYNeastaltdreekldvvaesIEKDLILLGATAIEDKLQEGVPETIELLRQAGIKI 650
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    705 RMVTGDNINTARAIATKCGILHPGEDFL---------CLEGKDFNRRIRNEKGEIEQERIDK---------------IWP 760
Cdd:TIGR01652  651 WVLTGDKVETAINIGYSCRLLSRNMEQIvitsdsldaTRSVEAAIKFGLEGTSEEFNNLGDSgnvalvidgkslgyaLDE 730
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    761 KLR------------VLA-RSSPTDKHTLVKGIIDSTvsdQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VAKEA 825
Cdd:TIGR01652  731 ELEkeflqlalkckaVICcRVSPSQKADVVRLVKKST---GKTTLAI-GDGANDVSMIQEADVG--VGISGKEgmQAVMA 804
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    826 SDIILTddNFTSIVKAVMW-GRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQ---MLWVNLIMDTLASLA 901
Cdd:TIGR01652  805 SDFAIG--QFRFLTKLLLVhGRWSYKRISKMILYFFYKNLIFAIIQFWYSFYNGFSGQTLYEgwyMVLYNVFFTALPVIS 882
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    902 LAT--EPPTESLLLRKP--YG---RNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNAPLHAPPSEHYT- 973
Cdd:TIGR01652  883 LGVfdQDVSASLSLRYPqlYRegqKGQGFSTKTFWGWMLDGIYQSLVIFFFPMFAYILGDFVSSGSVDDFSSVGVIVFTa 962
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    974 --IVFNTFVLMqlfnEINArkihgernvfegiFNNAIFCTIVlGTFVVQIIIVqfggkPFSCSELSIEQWLWSIFLGMGT 1051
Cdd:TIGR01652  963 lvVIVNLKIAL----EINR-------------WNWISLITIW-GSILVWLIFV-----IVYSSIFPSPAFYKAAPRVMGT 1019
                         1050      1060
                   ....*....|....*....|....*.
gi 48255947   1052 ------LLWGQLISTIPTSRLKFLKE 1071
Cdd:TIGR01652 1020 fgfwlvLLVIVLISLLPRFTYKAIQR 1045
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
174-873 2.27e-30

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 128.16  E-value: 2.27e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  174 DWSKEKQFRGL-QSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKK 252
Cdd:cd07550   81 DYTARKSEKALlDLLSPQERTVWVERDGVEVEVPADEVQPGDTVVVGAGDVIPVDGTVLSGEAL-IDQASLTGESLPVEK 159
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  253 SldKDPLLLSGTHVMEGSGRMVVTAVGVNSQTGIIFTLlgaggeeeekkdekkkekknkkqdgaIENRNKAKAQdgaame 332
Cdd:cd07550  160 R--EGDLVFASTVVEEGQLVIRAERVGRETRAARIAEL--------------------------IEQSPSLKAR------ 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  333 mqplkseeggdgdekdkkkanlpkkeksvLQGKLTKLAVQIGKAGLLMSAITviilvlyfvidtfWVQKRPWLAECTPIY 412
Cdd:cd07550  206 -----------------------------IQNYAERLADRLVPPTLGLAGLV-------------YALTGDISRAAAVLL 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  413 IQYfvkffiigvtvlVVAVPEGLPLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyi 492
Cdd:cd07550  244 VDF------------SCGIRLSTPVAVLSALNHAARHGI----LVKGGRALELLAKVDTVVFDKTGTLTEGEPEVTAI-- 305
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  493 nekhykkVPEPEAIPPNILSYLVTGI------SVNCAYTSKIlppEKEGG-LPRHvgnktecallgllldlkrdyqdvrn 565
Cdd:cd07550  306 -------ITFDGRLSEEDLLYLAASAeehfphPVARAIVREA---EERGIeHPEH------------------------- 350
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  566 eipEEALYKvytfnsVRKSMSTVLKNSD---GSYRIFskGASEIILKkcfkilsangeakvfrprdrdDIVKTVIEPMAS 642
Cdd:cd07550  351 ---EEVEYI------VGHGIASTVDGKRirvGSRHFM--EEEEIILI---------------------PEVDELIEDLHA 398
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  643 EGLRTICLAFRDFPAGepepewdnendivtgltciaVVGIEDPVRPEVPDAIKKCQRAG-ITVRMVTGDNINTARAIAtk 721
Cdd:cd07550  399 EGKSLLYVAIDGRLIG--------------------VIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALA-- 456
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  722 cgilhpgedflclegkdfnrrirnekgeiEQERIDkiwpklRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTND 801
Cdd:cd07550  457 -----------------------------EQLGID------RYHAEALPEDKAEIVE-----KLQAEGRTVAFVGDGIND 496
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 48255947  802 GPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:cd07550  497 SPALSYADVGISMR-GGTDIARETADVVLLEDDLRGLAEAIELARETMALIKRNIALVVGPNTAVLAGGVFG 567
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
179-948 5.27e-30

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 129.02  E-value: 5.27e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    179 KQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKY--GDLLPADGILIQGnDLKIDESSLTGESDHVKK---- 252
Cdd:TIGR01657  216 KQMQRLRDMVHKPQSVIVIRNGKWVTIASDELVPGDIVSIPRpeEKTMPCDSVLLSG-SCIVNESMLTGESVPVLKfpip 294
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    253 ------------SLDKDPLLLSGTHVM-------EGSGRMVVTAVGVN-SQTGIIFTLLgaggeeeekkdekkkekknkk 312
Cdd:TIGR01657  295 dngdddedlflyETSKKHVLFGGTKILqirpypgDTGCLAIVVRTGFStSKGQLVRSIL--------------------- 353
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    313 qdgaienrnkakaqdgaamemqplkseeggdgdekdkkkanLPKKEKSVLQGKLTKLAvqigkagLLMSAITVIILVlyF 392
Cdd:TIGR01657  354 -----------------------------------------YPKPRVFKFYKDSFKFI-------LFLAVLALIGFI--Y 383
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    393 VIDTFWVQKRPwlaectpiyiqyfVKFFIIGVT-VLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATA 471
Cdd:TIGR01657  384 TIIELIKDGRP-------------LGKIILRSLdIITIVVPPALPAELSIGINNSLARLKKKGIFCTSPFRINFAGKIDV 450
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    472 ICSDKTGTLTMNRMTVVQAYI---NEKHYKKVPEPEAIPPNILSYLVTgisvNCAYTSKIlppekEGGLprhVGNKTECA 548
Cdd:TIGR01657  451 CCFDKTGTLTEDGLDLRGVQGlsgNQEFLKIVTEDSSLKPSITHKALA----TCHSLTKL-----EGKL---VGDPLDKK 518
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    549 ----------LLGLLLDLKRDYQDVRNEIPEEALY--KVYTFNSVRKSMSTVLK-NSDGSYRIFSKGASEIILKKCfkil 615
Cdd:TIGR01657  519 mfeatgwtleEDDESAEPTSILAVVRTDDPPQELSiiRRFQFSSALQRMSVIVStNDERSPDAFVKGAPETIQSLC---- 594
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    616 sangeAKVFRPRDRDDIVKTVIepmaSEGLRTICLAFRDFpagePEPEWD-----NENDIVTGLTCIAVVGIEDPVRPEV 690
Cdd:TIGR01657  595 -----SPETVPSDYQEVLKSYT----REGYRVLALAYKEL----PKLTLQkaqdlSRDAVESNLTFLGFIVFENPLKPDT 661
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    691 PDAIKKCQRAGITVRMVTGDNINTARAIATKCGIL------------------------HPGEDF--------------- 731
Cdd:TIGR01657  662 KEVIKELKRASIRTVMITGDNPLTAVHVARECGIVnpsntlilaeaeppesgkpnqikfEVIDSIpfastqveipyplgq 741
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    732 ------------LCLEGKDFNRRIRNEKgeieqERIDKIWPKLRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGT 799
Cdd:TIGR01657  742 dsvedllasryhLAMSGKAFAVLQAHSP-----ELLLRLLSHTTVFARMAPDQKETLVE-----LLQKLDYTVGMCGDGA 811
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    800 NDGPALKKADVGFAMGIAGTDVAkeASdiiltddnFTSIVKAVmwgRNVYDSIskfLQFQLT-VNVVAVIVAFTGACITQ 878
Cdd:TIGR01657  812 NDCGALKQADVGISLSEAEASVA--AP--------FTSKLASI---SCVPNVI---REGRCAlVTSFQMFKYMALYSLIQ 875
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    879 ----------DSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRnkpLISRTMMKNILGhafyQLVVVFTLLF 948
Cdd:TIGR01657  876 fysvsilyliGSNLGDGQFLTIDLLLIFPVALLMSRNKPLKKLSKERPPSN---LFSVYILTSVLI----QFVLHILSQV 948
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
179-948 1.44e-28

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 123.51  E-value: 1.44e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  179 KQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITVGDIAQVKY-GDLLPADGILIQGNDLkIDESSLTGESDHVKKSLDKD 257
Cdd:cd07542   74 KQSKRLREMVHFTCPVRVIRDGEWQTISSSELVPGDILVIPDnGTLLPCDAILLSGSCI-VNESMLTGESVPVTKTPLPD 152
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  258 P-----------------LLLSGTHVME--GSGRMVVTAVGVnsQTGIiftllgaggeeeekkdekkkekknkkqdgaie 318
Cdd:cd07542  153 EsndslwsiysiedhskhTLFCGTKVIQtrAYEGKPVLAVVV--RTGF-------------------------------- 198
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  319 nrNKAKAQDGAAMeMQPlkseeggdgdekdkKKANLpkkeksvlqgKLTK-----LAVQIGKAGLLMsAITVIILVLYFV 393
Cdd:cd07542  199 --NTTKGQLVRSI-LYP--------------KPVDF----------KFYRdsmkfILFLAIIALIGF-IYTLIILILNGE 250
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  394 idtfwvqkrpwlaectpiyiqYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKmmkdnnLVRHLDAC---ETMGNAT 470
Cdd:cd07542  251 ---------------------SLGEIIIRALDIITIVVPPALPAALTVGIIYAQSR------LKKKGIFCispQRINICG 303
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  471 AI---CSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILppEKEGGLPrhVG----- 542
Cdd:cd07542  304 KInlvCFDKTGTLTEDGLDLWGVRPVSGNNFGDLEVFSLDLDLDSSLPNGPLLRAMATCHSL--TLIDGEL--VGdpldl 379
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  543 ---NKTECallgllldlkrdyqdvrneipEEALYKVYTFNSVRKSMSTVLK-NSDGSYRIFSKGASEIILKKCFKilsan 618
Cdd:cd07542  380 kmfEFTGW---------------------SLEILRQFPFSSALQRMSVIVKtPGDDSMMAFTKGAPEMIASLCKP----- 433
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  619 geAKVfrPRDRDDIVKTviepMASEGLRTICLAFRDFPAGEPEpEWDNENDIV-TGLTCIAVVGIEDPVRPEVPDAIKKC 697
Cdd:cd07542  434 --ETV--PSNFQEVLNE----YTKQGFRVIALAYKALESKTWL-LQKLSREEVeSDLEFLGLIVMENRLKPETAPVINEL 504
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  698 QRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKdfnrrirNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLV 777
Cdd:cd07542  505 NRANIRTVMVTGDNLLTAISVARECGMISPSKKVILIEAV-------KPEDDDSASLTWTLLLKGTVFARMSPDQKSELV 577
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  778 KGI--IDSTvsdqrqvVAVTGDGTNDGPALKKADVGFAMGIAGTDVAkeASdiiltddnFTSIVKAVmwgRNVYDSISK- 854
Cdd:cd07542  578 EELqkLDYT-------VGMCGDGANDCGALKAADVGISLSEAEASVA--AP--------FTSKVPDI---SCVPTVIKEg 637
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  855 -------FLQFQLTvnVVAVIVAFTGACI--TQDSPLKAVQMLWVNLIMDTLASLALATEPPTESLLLRKPYGRnkpLIS 925
Cdd:cd07542  638 raalvtsFSCFKYM--ALYSLIQFISVLIlySINSNLGDFQFLFIDLVIITPIAVFMSRTGAYPKLSSKRPPAS---LVS 712
                        810       820
                 ....*....|....*....|...
gi 48255947  926 RTMMKNILGHAFYQLVVVFTLLF 948
Cdd:cd07542  713 PPVLVSLLGQIVLILLFQVIGFL 735
P-type_ATPase_Cd-like cd07545
P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a ...
195-900 3.16e-28

P-type heavy metal-transporting ATPase, similar to Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase; CadA from gram-positive Staphylococcus aureus plasmid pI258 is required for full Cd(2+) and Zn(2+) resistance. This subfamily also includes CadA, from the gram-negative bacilli, Stenotrophomonas maltophilia D457R, which is a cadmium efflux pump acquired as part of a cluster of antibiotic and heavy metal resistance genes from gram-positive bacteria. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319845 [Multi-domain]  Cd Length: 599  Bit Score: 121.37  E-value: 3.16e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKSLDKDplLLSGThvmegsgrmv 274
Cdd:cd07545   99 LVRRDGQEREVPVAEVAVGDRMIVRPGERIAMDGIIVRGESS-VNQAAITGESLPVEKGVGDE--VFAGT---------- 165
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  275 vtavgVNsqtgiiftllgaggeeeekkdekkkekknkkQDGAIENRNKAKAQDGAAMEMQPLKSEEGGdgdekdkkkanl 354
Cdd:cd07545  166 -----LN-------------------------------GEGALEVRVTKPAEDSTIARIIHLVEEAQA------------ 197
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  355 pkkEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVLYFVIDTFwvqkrPWlaectpIYIqyfvkffiiGVTVLVVAVPEG 434
Cdd:cd07545  198 ---ERAPTQAFVDRFARYYTPVVMAIAALVAIVPPLFFGGAWF-----TW------IYR---------GLALLVVACPCA 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  435 LPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTmnrmtvvqayinekhyKKVPEpeaippnilsyl 514
Cdd:cd07545  255 LVISTPVSIVSAIGNAARKGVLIKGGVYLEELGRLKTVAFDKTGTLT----------------KGKPV------------ 306
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  515 VTGIsvncaytsKILPPEKEGGLPRHVGNktecallglllDLKRDYQDVRNEIPEEALYKVYTFNSVRKSMStvlknsdg 594
Cdd:cd07545  307 VTDV--------VVLGGQTEKELLAIAAA-----------LEYRSEHPLASAIVKKAEQRGLTLSAVEEFTA-------- 359
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  595 syrIFSKGASEIILKKCFKIlsanGEAKVFRPRDRDDIV--KTVIEPMASEGlRTICLafrdfpagepepewdnendIVT 672
Cdd:cd07545  360 ---LTGRGVRGVVNGTTYYI----GSPRLFEELNLSESPalEAKLDALQNQG-KTVMI-------------------LGD 412
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  673 GLTCIAVVGIEDPVRPEVPDAIKKCQRAGI--TVrMVTGDNINTARAIATKCGIlhpgedflclegkdfnrrirnekGEI 750
Cdd:cd07545  413 GERILGVIAVADQVRPSSRNAIAALHQLGIkqTV-MLTGDNPQTAQAIAAQVGV-----------------------SDI 468
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  751 EQERIdkiwpklrvlarssPTDKHTLVKGIidstvSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIIL 830
Cdd:cd07545  469 RAELL--------------PQDKLDAIEAL-----QAEGGRVAMVGDGVNDAPALAAADVGIAMGAAGTDTALETADIAL 529
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  831 TDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitqdsplkaVQMLWVNLIMDTLASL 900
Cdd:cd07545  530 MGDDLRKLPFAVRLSRKTLAIIKQNIAFALGIKLIALLLVIPG-----------WLTLWMAVFADMGASL 588
P-type_ATPase_HM_ZosA_PfeT-like cd07551
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which ...
198-873 1.33e-25

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis ZosA/PfeT which transports copper, and perhaps zinc under oxidative stress, and perhaps ferrous iron; Bacillus subtilis ZosA/PfeT (previously known as YkvW) transports copper, it may also transport zinc under oxidative stress and may also be involved in ferrous iron efflux. ZosA/PfeT is expressed under the regulation of the peroxide-sensing repressor PerR. It is involved in competence development. Disruption of the zosA/pfeT gene results in low transformability. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319849 [Multi-domain]  Cd Length: 611  Bit Score: 113.50  E-value: 1.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  198 RGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDlKIDESSLTGESDHVKKSLDKDplLLSGTHVMEGSGRMVVTA 277
Cdd:cd07551  119 RDGEIEEVPVEELQIGDRVQVRPGERVPADGVILSGSS-SIDEASITGESIPVEKTPGDE--VFAGTINGSGALTVRVTK 195
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  278 VGVNSQTGIIFTLLgaggeeeekkdekkkekknkkqdgaienrnkAKAQDgaamemqplkseeggdgdekdkkkanlpkk 357
Cdd:cd07551  196 LSSDTVFAKIVQLV-------------------------------EEAQS------------------------------ 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  358 EKSVLQGKLTKLavQIGKAGLLMSAITVIILVLYFVIDtfWvqkrPWLAEctpiyiqyfvkfFIIGVTVLVVAVPEGLPL 437
Cdd:cd07551  215 EKSPTQSFIERF--ERIYVKGVLLAVLLLLLLPPFLLG--W----TWADS------------FYRAMVFLVVASPCALVA 274
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  438 AVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEkhykkvPEPEAippnilsyLVTG 517
Cdd:cd07551  275 STPPATLSAIANAARQGVLFKGGVHLENLGSVKAIAFDKTGTLTEGKPRVTDVIPAE------GVDEE--------ELLQ 340
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  518 ISVNCAYTSkilppekEGGLPRHVGNKTEcallgLLLDLKRDYQDVRNEIpeealykvytfnsvrksmstvlknsdgsyr 597
Cdd:cd07551  341 VAAAAESQS-------EHPLAQAIVRYAE-----ERGIPRLPAIEVEAVT------------------------------ 378
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  598 ifSKGASEIILKKCFKIlsanGEAKVFRPRDRDDIVKTVIEPMASEGlRTICLAFRDfpagepepewdnenDIVtgltcI 677
Cdd:cd07551  379 --GKGVTATVDGQTYRI----GKPGFFGEVGIPSEAAALAAELESEG-KTVVYVARD--------------DQV-----V 432
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  678 AVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflclegkdfnrrirnekgeieqeriDK 757
Cdd:cd07551  433 GLIALMDTPRPEAKEAIAALRLGGIKTIMLTGDNERTAEAVAKELGI-------------------------------DE 481
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  758 IWPKLRvlarssPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTS 837
Cdd:cd07551  482 VVANLL------PEDKVAIIR-----ELQQEYGTVAMVGDGINDAPALANADVGIAMG-AGTDVALETADVVLMKDDLSK 549
                        650       660       670
                 ....*....|....*....|....*....|....*.
gi 48255947  838 IVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTG 873
Cdd:cd07551  550 LPYAIRLSRKMRRIIKQNLIFALAVIALLIVANLFG 585
P-type_ATPase_HM cd07544
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
192-873 5.93e-24

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319844 [Multi-domain]  Cd Length: 596  Bit Score: 108.18  E-value: 5.93e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  192 QKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVKKSldKDPLLLSGTHVMEGSG 271
Cdd:cd07544  110 RIAHRLVGGQLEEVPVEEVTVGDRLLVRPGEVVPVDGEVVSGTAT-LDESSLTGESKPVSKR--PGDRVMSGAVNGDSAL 186
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  272 RMVVTAVGVNSQTGIIFTLLGAggeeeekkdekkkekknkkqdgaienrnkAKAQDGAAMEMqplkseeggdGDekdkkk 351
Cdd:cd07544  187 TMVATKLAADSQYAGIVRLVKE-----------------------------AQANPAPFVRL----------AD------ 221
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  352 anlpkkeksVLQGKLTKLAVQIGKAGllmsaitviilvlyfvidtfwvqkrpWLAECTPiyiqyfVKFfiigVTVLVVAV 431
Cdd:cd07544  222 ---------RYAVPFTLLALAIAGVA--------------------------WAVSGDP------VRF----AAVLVVAT 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  432 PEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkVPEPEAIPPNIL 511
Cdd:cd07544  257 PCPLILAAPVAIVSGMSRSSRRGILVKDGGVLEKLARAKTVAFDKTGTLTYGQPKVVDV---------VPAPGVDADEVL 327
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  512 SyLVTgiSVNcAYTSKILPpekegglprhvgnktecallgllldlkrdyqdvrneipeEALYKVYTFNSVRKSMSTVLKN 591
Cdd:cd07544  328 R-LAA--SVE-QYSSHVLA---------------------------------------RAIVAAARERELQLSAVTELTE 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  592 SDGsyrifsKGASEIILKKCFKILSangeakvfrprdrddivktviepmaseglrticlafRDFPAGEPEPEWDNENDIV 671
Cdd:cd07544  365 VPG------AGVTGTVDGHEVKVGK------------------------------------LKFVLARGAWAPDIRNRPL 402
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  672 TGLTC--------IAVVGIEDPVRPEVPDAIKKCQRAGIT-VRMVTGDNINTARAIATKCGIlhpgedflclegkdfnrr 742
Cdd:cd07544  403 GGTAVyvsvdgkyAGAITLRDEVRPEAKETLAHLRKAGVErLVMLTGDRRSVAEYIASEVGI------------------ 464
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  743 irnekgeieqeriDKiwpklrVLARSSPTDKHTLVKGIidstvsDQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVA 822
Cdd:cd07544  465 -------------DE------VRAELLPEDKLAAVKEA------PKAGPTIMVGDGVNDAPALAAADVGIAMGARGSTAA 519
                        650       660       670       680       690
                 ....*....|....*....|....*....|....*....|....*....|....
gi 48255947  823 KEASDIILTDDNFTSIVKAVMWGRnvyDSISKFLQFQL---TVNVVAVIVAFTG 873
Cdd:cd07544  520 SEAADVVILVDDLDRVVDAVAIAR---RTRRIALQSVLigmALSIIGMLIAAFG 570
P-type_ATPase_Pb_Zn_Cd2-like cd07546
P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective ...
195-904 1.07e-22

P-type heavy metal-transporting ATPase, similar to Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+); Escherichia coli ZntA mediates resistance to toxic levels of selected divalent metal ions. ZntA has the highest selectivity for Pb(2+), followed by Zn(2+) and Cd(2+); it also shows low levels of activity with Cu(2+), Ni(2+), and Co(2+). It is upregulated by the transcription factor ZntR at high zinc concentrations. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319846 [Multi-domain]  Cd Length: 597  Bit Score: 104.02  E-value: 1.07e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  195 TVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDlKIDESSLTGESDHVKKSldkdplllSGTHVMEGSgrmv 274
Cdd:cd07546  102 LREENGERREVPADSLRPGDVIEVAPGGRLPADGELLSGFA-SFDESALTGESIPVEKA--------AGDKVFAGS---- 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  275 vtavgVNSqtgiiftllgaggeeeekkdekkkekknkkqDGAIENRNKAKAQDGAAMEMQPLKseeggdgDEKDKKKANL 354
Cdd:cd07546  169 -----INV-------------------------------DGVLRIRVTSAPGDNAIDRILHLI-------EEAEERRAPI 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  355 PKKeksvlqgkLTKLAVQIGKAGLLMSAITVIILVLYFVIDtfWvqkRPWlaectpIYIqyfvkffiiGVTVLVVAVPEG 434
Cdd:cd07546  206 ERF--------IDRFSRWYTPAIMAVALLVIVVPPLLFGAD--W---QTW------IYR---------GLALLLIGCPCA 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  435 L----PLAVTISLAYSVKKMMkdnnLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkVPEPEAIPPNI 510
Cdd:cd07546  258 LvistPAAITSGLAAAARRGA----LIKGGAALEQLGRVTTVAFDKTGTLTRGKPVVTDV---------VPLTGISEAEL 324
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  511 LSyLVTGISVNCAYTskilppekeggLPRHVGNKTECALLgllldlkrdyqdvrneIPEEAlykvytfnSVRKSMStvlk 590
Cdd:cd07546  325 LA-LAAAVEMGSSHP-----------LAQAIVARAQAAGL----------------TIPPA--------EEARALV---- 364
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  591 nsdgsyrifSKGASEIILKKCFKILSANGEAKVFRPRdrddiVKTVIEPMASEGlRTICLAFRdfpagepepewdneNDI 670
Cdd:cd07546  365 ---------GRGIEGQVDGERVLIGAPKFAADRGTLE-----VQGRIAALEQAG-KTVVVVLA--------------NGR 415
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  671 VTGLtciavVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflclegkDFNRRIRnekgei 750
Cdd:cd07546  416 VLGL-----IALRDELRPDAAEAVAELNALGIKALMLTGDNPRAAAAIAAELGL-------------DFRAGLL------ 471
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  751 eqeridkiwpklrvlarssPTDKHTLVKGIidstvsDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIIL 830
Cdd:cd07546  472 -------------------PEDKVKAVREL------AQHGPVAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAAL 525
                        650       660       670       680       690       700       710
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 48255947  831 TDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacITQdsplkavqmLWVNLIMDTLASlALAT 904
Cdd:cd07546  526 THNRLGGVAAMIELSRATLANIRQNITIALGLKAVFLVTTLLG--ITG---------LWLAVLADTGAT-VLVT 587
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
199-822 1.76e-22

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 104.21  E-value: 1.76e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  199 GGQVIQIPVADITVGDIAQVKY-GDLLPADGILIQGNdLKIDESSLTGES----------DHVKKSLD-----KDPLLLS 262
Cdd:cd02082   94 GYQEITIASNMIVPGDIVLIKRrEVTLPCDCVLLEGS-CIVTEAMLTGESvpigkcqiptDSHDDVLFkyessKSHTLFQ 172
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  263 GTHVM-----EGSG-RMVVTAVGVNSQTGIIFtllgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqpl 336
Cdd:cd02082  173 GTQVMqiippEDDIlKAIVVRTGFGTSKGQLI------------------------------------------------ 204
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  337 kseeggdgdekdkkkanlpkkeKSVLQGKLTKLAVQigkaglLMSAITVIILVLYFVIDTFWVQKRPWLAECTPIYIqyF 416
Cdd:cd02082  205 ----------------------RAILYPKPFNKKFQ------QQAVKFTLLLATLALIGFLYTLIRLLDIELPPLFI--A 254
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  417 VKFFIIgvtvLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMtVVQAYINEKH 496
Cdd:cd02082  255 FEFLDI----LTYSVPPGLPMLIAITNFVGLKRLKKNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKL-DLIGYQLKGQ 329
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  497 YKKVPEPEAIPPNILSYLVTGISVnCAYTSKIlppekEGGLprhVGNKTECALLGLLLDLkRDYQDVRNEIPEEA----- 571
Cdd:cd02082  330 NQTFDPIQCQDPNNISIEHKLFAI-CHSLTKI-----NGKL---LGDPLDVKMAEASTWD-LDYDHEAKQHYSKSgtkrf 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  572 -LYKVYTFNSVRKSMSTVLK-----NSDGSYRIFSKGASEIILKKCFKIlsangeakvfrPRDRDDIVKTVIEpmasEGL 645
Cdd:cd02082  400 yIIQVFQFHSALQRMSVVAKevdmiTKDFKHYAFIKGAPEKIQSLFSHV-----------PSDEKAQLSTLIN----EGY 464
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  646 RTICLAFRDFPAGEPEPEWDNEND-IVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGI 724
Cdd:cd02082  465 RVLALGYKELPQSEIDAFLDLSREaQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQELEI 544
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  725 LHPGEDFLCLEGkdfnrrIRNEKGEIEQERIDKIwPKLRVLARSSPTDKHTLVKGIIDSTvsdqrQVVAVTGDGTNDGPA 804
Cdd:cd02082  545 INRKNPTIIIHL------LIPEIQKDNSTQWILI-IHTNVFARTAPEQKQTIIRLLKESD-----YIVCMCGDGANDCGA 612
                        650
                 ....*....|....*...
gi 48255947  805 LKKADVGFAMGIAGTDVA 822
Cdd:cd02082  613 LKEADVGISLAEADASFA 630
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
418-814 1.43e-21

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 101.31  E-value: 1.43e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  418 KFFIIGVTVLVVAVPEGLP----LAVTISLAYSVKKMMKDNNLVR-----HLDACetmgnataiCSDKTGTLTMNRMtVV 488
Cdd:cd07543  260 KLFLECTLILTSVVPPELPmelsLAVNTSLIALAKLYIFCTEPFRipfagKVDIC---------CFDKTGTLTSDDL-VV 329
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  489 Q--AYINEKHyKKVPEPEAIPPNILSYLVTGISVNCAYTSKIL--PPEKegGLPRHVGNKTECALLGLLLDLKrdyqdvr 564
Cdd:cd07543  330 EgvAGLNDGK-EVIPVSSIEPVETILVLASCHSLVKLDDGKLVgdPLEK--ATLEAVDWTLTKDEKVFPRSKK------- 399
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  565 neIPEEALYKVYTFNSVRKSMSTV-----LKNSDGSYRIFSKGASEIIlKKCFKILsangeakvfrPRDRDDIVKTviep 639
Cdd:cd07543  400 --TKGLKIIQRFHFSSALKRMSVVasykdPGSTDLKYIVAVKGAPETL-KSMLSDV----------PADYDEVYKE---- 462
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  640 MASEGLRTICLAFRDFPAGEPEPEWD-NENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAI 718
Cdd:cd07543  463 YTRQGSRVLALGYKELGHLTKQQARDyKREDVESDLTFAGFIVFSCPLKPDSKETIKELNNSSHRVVMITGDNPLTACHV 542
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  719 ATKCGIlhpgedflclegkdfnrrIRNEKGEIEQERIDKIW-----PKLRVLARSSPTDKHTLVkgiidSTVSDQRQVVA 793
Cdd:cd07543  543 AKELGI------------------VDKPVLILILSEEGKSNewkliPHVKVFARVAPKQKEFII-----TTLKELGYVTL 599
                        410       420
                 ....*....|....*....|.
gi 48255947  794 VTGDGTNDGPALKKADVGFAM 814
Cdd:cd07543  600 MCGDGTNDVGALKHAHVGVAL 620
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
191-869 2.07e-20

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 97.67  E-value: 2.07e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  191 EQKFTVIRGGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLK----IDESSLTGESD-HVKKSLDKDPLLLSGTH 265
Cdd:cd07536   82 KKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQgscyVETAQLDGETDlKLRVAVSCTQQLPALGD 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  266 VMEGSGrmVVTAVGVNSQtgiIFTLLGaggeeeekkdekkkekkNKKQDGAIENRNKAKAQDGAAMEMQPLKSEEGGDGd 345
Cdd:cd07536  162 LMKISA--YVECQKPQMD---IHSFEG-----------------NFTLEDSDPPIHESLSIENTLLRASTLRNTGWVIG- 218
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  346 ekdkkkanlpkkeKSVLQGKLTKLAVQIGKAGL-----------LMSAITVIILVLYFVIDT---FWvqkRPWLAEcTPI 411
Cdd:cd07536  219 -------------VVVYTGKETKLVMNTSNAKNkvglldlelnrLTKALFLALVVLSLVMVTlqgFW---GPWYGE-KNW 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  412 YIQY----FVKFFIIGVTVLVV---AVPEGLPLAVTISLAYSVKKMMKDNNL----------VRHLDACETMGNATAICS 474
Cdd:cd07536  282 YIKKmdttSDNFGRNLLRFLLLfsyIIPISLRVNLDMVKAVYAWFIMWDENMyyigndtgtvARTSTIPEELGQVVYLLT 361
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  475 DKTGTLTMNRMTVVQAYINEKHYkkvpepeaippnilsylvtgisvncaytskilppekeGGlprhvgnktecallglll 554
Cdd:cd07536  362 DKTGTLTQNEMIFKRCHIGGVSY-------------------------------------GG------------------ 386
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  555 dlkrdyQDVRNEIPEealykVYTFNSVRKSMSTVLKN-SDGSYRIFSKGASEIIlkkcFKILSANGEAKVFrprdrddiv 633
Cdd:cd07536  387 ------QVLSFCILQ-----LLEFTSDRKRMSVIVRDeSTGEITLYMKGADVAI----SPIVSKDSYMEQY--------- 442
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  634 KTVIEPMASEGLRTICLAFRDFPAGEPEpEW------------DNENDIVT-------GLTCIAVVGIEDPVRPEVPDAI 694
Cdd:cd07536  443 NDWLEEECGEGLRTLCVAKKALTENEYQ-EWesryteaslslhDRSLRVAEvveslerELELLGLTAIEDRLQAGVPETI 521
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  695 KKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCL--EGKDFNRR--------IRNEKGE--------------- 749
Cdd:cd07536  522 ETLRKAGIKIWMLTGDKQETAICIAKSCHLVSRTQDIHLLrqDTSRGERAaitqhahlELNAFRRkhdvalvidgdslev 601
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  750 ----IEQERID-KIWPKLRVLARSSPTDKHTLVKgIIDStvSDQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTD--VA 822
Cdd:cd07536  602 alkyYRHEFVElACQCPAVICCRVSPTQKARIVT-LLKQ--HTGRRTLAI-GDGGNDVSMIQAADCG--VGISGKEgkQA 675
                        730       740       750       760
                 ....*....|....*....|....*....|....*....|....*...
gi 48255947  823 KEASDIILTddNFTSIVKAVM-WGRNVYDSISKFLQFQLTVNVVAVIV 869
Cdd:cd07536  676 SLAADYSIT--QFRHLGRLLLvHGRNSYNRSAALGQYVFYKGLIISTI 721
P-type_ATPase_K cd02078
potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic ...
199-846 1.12e-18

potassium-transporting ATPase ATP-binding subunit, KdpB, a subunit of the prokaryotic high-affinity potassium uptake system KdpFABC; similar to Escherichia coli KdpB; KdpFABC is a prokaryotic high-affinity potassium uptake system. It is expressed under K(+) limiting conditions when the other potassium transport systems are not able to provide a sufficient flow of K(+) into the bacteria. The KdpB subunit represents the catalytic subunit performing ATP hydrolysis. KdpB is comprised of four domains: the transmembrane domain, the nucleotide-binding domain, the phosphorylation domain, and the actuator domain. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319773 [Multi-domain]  Cd Length: 667  Bit Score: 91.55  E-value: 1.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  199 GGQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNdLKIDESSLTGESDHV-KKSLDKDPLLLSGTHVMegSGRMVVTa 277
Cdd:cd02078  103 DGKIEKVPATDLKKGDIVLVEAGDIIPADGEVIEGV-ASVDESAITGESAPViRESGGDRSSVTGGTKVL--SDRIKVR- 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  278 vgVNSQTGIIFTllgaggeeeekkdekkkekknkkqDGAIENRNKAKAQdgaamemqplkseeggdgdekdkKKANlpkk 357
Cdd:cd02078  179 --ITANPGETFL------------------------DRMIALVEGASRQ-----------------------KTPN---- 205
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  358 eksvlqgkltKLAVQIgkaglLMSAITVIILVlyfVIDTFWvqkrpwlaectPIYIQYFVKffiIGVTVLV---VA-VPE 433
Cdd:cd02078  206 ----------EIALTI-----LLVGLTLIFLI---VVATLP-----------PFAEYSGAP---VSVTVLVallVClIPT 253
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  434 ---GLPLAVTISlaySVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTM-NRMTVvqayinekhykkvpepEAIPpn 509
Cdd:cd02078  254 tigGLLSAIGIA---GMDRLLRFNVIAKSGRAVEAAGDVDTLLLDKTGTITLgNRQAT----------------EFIP-- 312
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  510 ilsylVTGISVN----CAYTSKILPPEKEGglprhvgnktecalLGLLLDLKRDYQDVRNEIPEEAlyKVYTFnSVRKSM 585
Cdd:cd02078  313 -----VGGVDEKeladAAQLASLADETPEG--------------RSIVILAKQLGGTERDLDLSGA--EFIPF-SAETRM 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  586 STVlkNSDGSYRIfSKGASEIILKKcfkILSANGEAkvfrPRDRDDIVKTViepmASEGLRTICLAfrdfpagepepewd 665
Cdd:cd02078  371 SGV--DLPDGTEI-RKGAVDAIRKY---VRSLGGSI----PEELEAIVEEI----SKQGGTPLVVA-------------- 422
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  666 nENDIVTGltciaVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgEDFLclegkdfnrrirn 745
Cdd:cd02078  423 -EDDRVLG-----VIYLKDIIKPGIKERFAELRKMGIKTVMITGDNPLTAAAIAAEAGV----DDFL------------- 479
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  746 ekgeieqeridkiwpklrvlARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEA 825
Cdd:cd02078  480 --------------------AEAKPEDKLELIR-----KEQAKGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEA 533
                        650       660
                 ....*....|....*....|.
gi 48255947  826 SDIILTDDNFTSIVKAVMWGR 846
Cdd:cd02078  534 GNMVDLDSDPTKLIEVVEIGK 554
P-type_ATPase-Cd_Zn_Co_like cd07548
P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to ...
682-846 3.63e-16

P-type heavy metal-transporting ATPase, similar to Bacillus subtilis CadA which appears to transport cadmium, zinc and cobalt but not copper out of the cell; Bacillus subtilis CadA/YvgW appears to transport cadmium, zinc and cobalt but not copper, out of the cell. Functions in metal ion resistance and cellular metal ion homeostasis. CadA/YvgW is also important for sporulation in B. subtilis, the significant specific expression of the cadA/yvgW gene during the late stage of sporulation, is controlled by forespore-specific sigma factor, sigma G, and mother cell-specific sigma factor, sigma E. This subfamily also includes Helicobacter pylori CadA an essential resistance pump with ion specificity towards Cd(2+), Zn(2+) and Co(2+), and Zn-transporting ATPase, ZiaA(N) in Synechocystis PCC 6803. Transcription of ziaA is induced by Zn under the control of the Zn responsive repressor ZiaR. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319847 [Multi-domain]  Cd Length: 604  Bit Score: 83.44  E-value: 3.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  682 IEDPVRPEVPDAIKKCQRAGIT-VRMVTGDNINTARAIATKCGILHPGEDFLclegkdfnrrirnekgeieqeridkiwp 760
Cdd:cd07548  426 ISDEIKEDAKEAIKGLKELGIKnLVMLTGDRKSVAEKVAKKLGIDEVYAELL---------------------------- 477
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  761 klrvlarssPTDKHTLVKGIIDSTvsdqRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVK 840
Cdd:cd07548  478 ---------PEDKVEKVEELKAES----KGKVAFVGDGINDAPVLARADVGIAMGGLGSDAAIEAADVVLMNDEPSKVAE 544

                 ....*.
gi 48255947  841 AVMWGR 846
Cdd:cd07548  545 AIKIAR 550
P-type_ATPase_FixI-like cd02092
Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ...
200-884 3.77e-16

Rhizobium meliloti FixI and related proteins; belongs to P-type heavy metal-transporting ATPase subfamily; FixI may be a pump of a specific cation involved in symbiotic nitrogen fixation. The Rhizobium fixI gene is part of an operon conserved among rhizobia, fixGHIS. FixG, FixH, FixI, and FixS may participate in a membrane-bound complex coupling the FixI cation pump with a redox process catalyzed by FixG, an iron-sulfur protein. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319782 [Multi-domain]  Cd Length: 605  Bit Score: 83.56  E-value: 3.77e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  200 GQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNDLkIDESSLTGESDHVkkSLDKDPLLLSGTHVMEGSGRMVVTAVG 279
Cdd:cd02092  135 GSREYVPVAEIRPGDRVLVAAGERIPVDGTVVSGTSE-LDRSLLTGESAPV--TVAPGDLVQAGAMNLSGPLRLRATAAG 211
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  280 VNsqtgiifTLLgaggeeeekkdekkkekknkkqdgaienrnkakAQDGAAMEMqplkSEEGgdgdekdkkkanlpkkek 359
Cdd:cd02092  212 DD-------TLL---------------------------------AEIARLMEA----AEQG------------------ 229
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  360 svlQGKLTKLAvqiGKAGLLMSAITVIILVLYFVIdtfwvqkrpWLAECTPIYiqyfvKFFIIGVTVLVVAVPEGLPLAV 439
Cdd:cd02092  230 ---RSRYVRLA---DRAARLYAPVVHLLALLTFVG---------WVAAGGDWR-----HALLIAVAVLIITCPCALGLAV 289
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  440 TISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkvpepEAIPPNILSYLvtgis 519
Cdd:cd02092  290 PAVQVVASGRLFRRGVLVKDGTALERLAEVDTVVFDKTGTLTLGSPRLVGA-------------HAISADLLALA----- 351
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  520 vncaytskilppekeGGLPRHvgnktecallgllldlkrdyqdvrneipeealykvytfnsVRKSMSTVLKNSDGSYRIF 599
Cdd:cd02092  352 ---------------AALAQA----------------------------------------SRHPLSRALAAAAGARPVE 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  600 SKGASEIilkkcfkilSANG-EAKVfrprdrddivktviepmaseGLRTICLAFRDFPAGEPEPEWDNENDIVTGLTCIA 678
Cdd:cd02092  377 LDDAREV---------PGRGvEGRI--------------------DGARVRLGRPAWLGASAGVSTASELALSKGGEEAA 427
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  679 VVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHpgedflclegkdfnrrirnekgeieqeridki 758
Cdd:cd02092  428 RFPFEDRPRPDAREAISALRALGLSVEILSGDREPAVRALARALGIED-------------------------------- 475
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  759 wpklrVLARSSPTDKHTLVkgiidSTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIILTDDNFTSI 838
Cdd:cd02092  476 -----WRAGLTPAEKVARI-----EELKAQGRRVLMVGDGLNDAPALAAAHVSMAPASA-VDASRSAADIVFLGDSLAPV 544
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*.
gi 48255947  839 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGacitQDSPLKA 884
Cdd:cd02092  545 PEAIEIARRARRLIRQNFALAIGYNVIAVPLAIAG----YVTPLIA 586
copA PRK10671
copper-exporting P-type ATPase CopA;
205-842 4.06e-16

copper-exporting P-type ATPase CopA;


Pssm-ID: 182635 [Multi-domain]  Cd Length: 834  Bit Score: 83.64  E-value: 4.06e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   205 IPVADITVGDIAQVKYGDLLPADGILIQGnDLKIDESSLTGESDHVKKSLDKDplLLSGTHVMEGSgrMVVTAVGVNSQT 284
Cdd:PRK10671  336 VPLADVQPGMLLRLTTGDRVPVDGEITQG-EAWLDEAMLTGEPIPQQKGEGDS--VHAGTVVQDGS--VLFRASAVGSHT 410
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   285 giiftllgaggeeeekkdekkkekknkkqdgaienrnkakaqdgaamemqplkseeggdgdekdkkkaNLPKKEKSVLQG 364
Cdd:PRK10671  411 --------------------------------------------------------------------TLSRIIRMVRQA 422
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   365 KLTKlaVQIGKAGLLMSAITVIILVLYFVIDT---FWVQKRPWLaectpiyiqyfVKFFIIGVTVLVVAVPEGLPLAVTI 441
Cdd:PRK10671  423 QSSK--PEIGQLADKISAVFVPVVVVIALVSAaiwYFFGPAPQI-----------VYTLVIATTVLIIACPCALGLATPM 489
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   442 SLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYInekhYKKVPEPEAIppNILSYLVTGISVN 521
Cdd:PRK10671  490 SIISGVGRAAEFGVLVRDADALQRASTLDTLVFDKTGTLTEGKPQVVAVKT----FNGVDEAQAL--RLAAALEQGSSHP 563
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   522 CAYTskILppEKEGGLprhvgnktecallgllldlkrdyqdvrneipeeALYKVYTFNSVR-KSMSTVLknsDGSYRIFS 600
Cdd:PRK10671  564 LARA--IL--DKAGDM---------------------------------TLPQVNGFRTLRgLGVSGEA---EGHALLLG 603
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   601 KGAseiilkkcfkILSANGEAKvfrprdrdDIVKTVIEPMASEGLRTICLAfrdfpagepepewdnendiVTGlTCIAVV 680
Cdd:PRK10671  604 NQA----------LLNEQQVDT--------KALEAEITAQASQGATPVLLA-------------------VDG-KAAALL 645
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   681 GIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflclegkdfnrrirnekgeieqeriDkiwp 760
Cdd:PRK10671  646 AIRDPLRSDSVAALQRLHKAGYRLVMLTGDNPTTANAIAKEAGI-------------------------------D---- 690
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   761 klRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSIVK 840
Cdd:PRK10671  691 --EVIAGVLPDGKAEAIK-----RLQSQGRQVAMVGDGINDAPALAQADVGIAMG-GGSDVAIETAAITLMRHSLMGVAD 762

                  ..
gi 48255947   841 AV 842
Cdd:PRK10671  763 AL 764
Cation_ATPase_N pfam00690
Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, ...
51-120 1.50e-15

Cation transporter/ATPase, N-terminus; Members of this families are involved in Na+/K+, H+/K+, Ca++ and Mg++ transport.


Pssm-ID: 459907 [Multi-domain]  Cd Length: 68  Bit Score: 72.21  E-value: 1.50e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947     51 ESYGDVYGICTKLKTSPNEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIV 120
Cdd:pfam00690    1 WHALSVEEVLKKLGTDLEKGLT--EAEAEKRLKKYGPNELPEKKPKSLWKLFLRQFKDPLIIILLIAAIV 68
zntA PRK11033
zinc/cadmium/mercury/lead-transporting ATPase; Provisional
677-831 2.91e-15

zinc/cadmium/mercury/lead-transporting ATPase; Provisional


Pssm-ID: 236827 [Multi-domain]  Cd Length: 741  Bit Score: 80.81  E-value: 2.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   677 IAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgedflclegkDFNrrirnekgeieqerid 756
Cdd:PRK11033  560 LGLIALQDTLRADARQAISELKALGIKGVMLTGDNPRAAAAIAGELGI-------------DFR---------------- 610
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48255947   757 kiwpklrvlARSSPTDKhtlVKGIidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILT 831
Cdd:PRK11033  611 ---------AGLLPEDK---VKAV---TELNQHAPLAMVGDGINDAPAMKAASIGIAMG-SGTDVALETADAALT 669
kdpB TIGR01497
K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the ...
679-915 3.30e-15

K+-transporting ATPase, B subunit; This model describes the P-type ATPase subunit of the complex responsible for translocating potassium ions across biological membranes in microbes. In E. coli and other species, this complex consists of the proteins KdpA, KdpB, KdpC and KdpF. KdpB is the ATPase subunit, while KdpA is the potassium-ion translocating subunit. The function of KdpC is unclear, although cit has been suggested to couple the ATPase subunit to the ion-translocating subunit, while KdpF serves to stabilize the complex. The potassium P-type ATPases have been characterized as Type IA based on a phylogenetic analysis which places this clade closest to the heavy-metal translocating ATPases (Type IB). Others place this clade closer to the Na+/K+ antiporter type (Type IIC) based on physical characteristics. This model is very clear-cut, with a strong break between trusted hits and noise. All members of the seed alignment, from Clostridium, Anabaena and E. coli are in the characterized table. One sequence above trusted, OMNI|NTL01TA01282, is apparently mis-annotated in the primary literature, but properly annotated by TIGR. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130561 [Multi-domain]  Cd Length: 675  Bit Score: 80.70  E-value: 3.30e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    679 VVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGIlhpgEDFLclegkdfnrrirnekgeieqeridki 758
Cdd:TIGR01497  440 VIYLKDIVKGGIKERFAQLRKMGIKTIMITGDNRLTAAAIAAEAGV----DDFI-------------------------- 489
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    759 wpklrvlARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSI 838
Cdd:TIGR01497  490 -------AEATPEDKIALIR-----QEQAEGKLVAMTGDGTNDAPALAQADVGVAMN-SGTQAAKEAANMVDLDSDPTKL 556
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    839 VKAVMWGRNVYDSISKFLQFQLTVNVV---AVIVAFTGACITQ---------DSPLKAV--QMLWVNLIMDTLASLAL-- 902
Cdd:TIGR01497  557 IEVVHIGKQLLITRGALTTFSIANDVAkyfAIIPAIFAAAYPQlqalnimclHSPDSAIlsALIFNALIIPALIPLALkg 636
                          250
                   ....*....|....
gi 48255947    903 -ATEPPTESLLLRK 915
Cdd:TIGR01497  637 vSYRPLTASALLRR 650
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
528-611 4.52e-15

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 463817 [Multi-domain]  Cd Length: 91  Bit Score: 71.48  E-value: 4.52e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    528 ILPPEKEGGLPRHVGNKTECALLGLLLDLKRDYQDVRNEIPEEAlykVYTFNSVRKSMSTVLKN-SDGSYRIFSKGASEI 606
Cdd:pfam13246    7 AFDENEEKGKWEIVGDPTESALLVFAEKMGIDVEELRKDYPRVA---EIPFNSDRKRMSTVHKLpDDGKYRLFVKGAPEI 83

                   ....*
gi 48255947    607 ILKKC 611
Cdd:pfam13246   84 ILDRC 88
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
409-858 6.93e-15

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 79.76  E-value: 6.93e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  409 TPIYIQYFvKFFIIGVTVLVVAvpeglpLAVTISLAYSV--KKMMKDNNL----VRHLDACETMGNATAICSDKTGTLTM 482
Cdd:cd07541  267 GPWYIYLF-RFLILFSSIIPIS------LRVNLDMAKIVysWQIEHDKNIpgtvVRTSTIPEELGRIEYLLSDKTGTLTQ 339
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  483 NRMtvvqayinekHYKKVP-EPEAIPPNILSYlvtgisvncaytsKILppekegglprhvgnktecallgllldlkrdyq 561
Cdd:cd07541  340 NEM----------VFKKLHlGTVSYGGQNLNY-------------EIL-------------------------------- 364
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  562 dvrneipeealyKVYTFNSVRKSMSTVLKN-SDGSYRIFSKGASEIILKkcfkILSANgeakvfrprdrdDIVKTVIEPM 640
Cdd:cd07541  365 ------------QIFPFTSESKRMGIIVREeKTGEITFYMKGADVVMSK----IVQYN------------DWLEEECGNM 416
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  641 ASEGLRTICLAFRDFPAGEPEpEWDNEND-------------------IVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAG 701
Cdd:cd07541  417 AREGLRTLVVAKKKLSEEEYQ-AFEKRYNaaklsihdrdlkvaevvesLERELELLCLTGVEDKLQEDVKPTLELLRNAG 495
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  702 ITVRMVTGDNINTARAIATKCGI------LH-------PGEDFLCLegkDFNRRIRNEK------------GEIEQERID 756
Cdd:cd07541  496 IKIWMLTGDKLETATCIAKSSKLvsrgqyIHvfrkvttREEAHLEL---NNLRRKHDCAlvidgeslevclKYYEHEFIE 572
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  757 KIWPKLRVLA-RSSPTDKHTLVKGIIDSTvsdQRQVVAVtGDGTNDGPALKKADVGfaMGIAGTDvAKEAS---DIILTD 832
Cdd:cd07541  573 LACQLPAVVCcRCSPTQKAQIVRLIQKHT---GKRTCAI-GDGGNDVSMIQAADVG--VGIEGKE-GKQASlaaDFSITQ 645
                        490       500
                 ....*....|....*....|....*..
gi 48255947  833 dnFTSIVKAVMW-GRNVYDSISKFLQF 858
Cdd:cd07541  646 --FSHIGRLLLWhGRNSYKRSAKLAQF 670
ATP_Ca_trans_C pfam12424
Plasma membrane calcium transporter ATPase C terminal; This domain family is found in ...
1103-1142 2.05e-12

Plasma membrane calcium transporter ATPase C terminal; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with pfam00689, pfam00122, pfam00702, pfam00690. There is a conserved QTQ sequence motif. This family is the C terminal of a calcium transporting ATPase located in the plasma membrane.


Pssm-ID: 463575  Cd Length: 47  Bit Score: 62.81  E-value: 2.05e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 48255947   1103 GQILWFRGLNRIQTQMDVVNAFQSG--SSIQGALRRQpSIAS 1142
Cdd:pfam12424    1 GQILWFRGLNRIQTQIRVVKAFQSSlrEGIQKPYLRN-SIHS 41
P-type_ATPase_HM cd07553
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
200-884 5.78e-12

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319851 [Multi-domain]  Cd Length: 610  Bit Score: 69.85  E-value: 5.78e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  200 GQVIQIPVADITVGDIAQVKYGDLLPADGILIQGNdLKIDESSLTGESDHVKKslDKDPLLLSGTHVMEGSGRMVVTAVG 279
Cdd:cd07553  136 GSRIKTRADQIKSGDVYLVASGQRVPVDGKLLSEQ-ASIDMSWLTGESLPRIV--ERGDKVPAGTSLENQAFEIRVEHSL 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  280 VNSQTGIIFtllgaggeeeekkdekkkekknkkqdgaienrNKAKAQDGAAMEMQPLKSEEGGdgdekdkkkanlpkkek 359
Cdd:cd07553  213 AESWSGSIL--------------------------------QKVEAQEARKTPRDLLADKIIH----------------- 243
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  360 svlqgkltklavqigkagllmsAITVIILVLYFVIDTFWVQkrpwlaectpIYIQYFVKFFIigvTVLVVAVPEGLPLAV 439
Cdd:cd07553  244 ----------------------YFTVIALLIAVAGFGVWLA----------IDLSIALKVFT---SVLIVACPCALALAT 288
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  440 TISLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAyinekhykkvpEPEAIPPNILSYlvtgIS 519
Cdd:cd07553  289 PFTDEIALARLKKKGVLIKNASSLERLSRVRTIVFDKTGTLTRGKSSFVMV-----------NPEGIDRLALRA----IS 353
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  520 VNCAYTskilppekegglpRHVGNKTecallgllldlkrdyqdVRNEIPEEALYKVYTFNSVRKSMSTVLKNSDGS-YRI 598
Cdd:cd07553  354 AIEAHS-------------RHPISRA-----------------IREHLMAKGLIKAGASELVEIVGKGVSGNSSGSlWKL 403
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  599 FSKgaseiilkkCFKIlsANGEAKVFRPRDRddivktviepmaseglrticlafrdfpagepepewdnendivtglTCIA 678
Cdd:cd07553  404 GSA---------PDAC--GIQESGVVIARDG---------------------------------------------RQLL 427
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  679 VVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGiLHPGEdflclegkdfnrrirnekgeieqeridki 758
Cdd:cd07553  428 DLSFNDLLRPDSNREIEELKKGGLSIAILSGDNEEKVRLVGDSLG-LDPRQ----------------------------- 477
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  759 wpklrVLARSSPTDKHTLVKgiidstvSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEASDIILTDDNFTSI 838
Cdd:cd07553  478 -----LFGNLSPEEKLAWIE-------SHSPENTLMVGDGANDALALASAFVGIAVA-GEVGVSLEAADIYYAGNGIGGI 544
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|....*.
gi 48255947  839 VKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACitqdSPLKA 884
Cdd:cd07553  545 RDLLTLSKQTIKAIKGLFAFSLLYNLVAIGLALSGWI----SPLVA 586
Cation_ATPase_N smart00831
Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region ...
59-124 1.09e-10

Cation transporter/ATPase, N-terminus; This entry represents the conserved N-terminal region found in several classes of cation-transporting P-type ATPases, including those that transport H+, Na+, Ca2+, Na+/K+, and H+/K+. In the H+/K+- and Na+/K+-exchange P-ATPases, this domain is found in the catalytic alpha chain. In gastric H+/K+-ATPases, this domain undergoes reversible sequential phosphorylation inducing conformational changes that may be important for regulating the function of these ATPases.


Pssm-ID: 214842 [Multi-domain]  Cd Length: 75  Bit Score: 58.75  E-value: 1.09e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48255947      59 ICTKLKTSPNEGLSgnPADLERREAVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGL 124
Cdd:smart00831   12 VLERLQTDLEKGLS--SEEAARRLERYGPNELPPPKKTSPLLRFLRQFHNPLIYILLAAAVLSALL 75
PRK14010 PRK14010
K(+)-transporting ATPase subunit B;
667-864 1.28e-10

K(+)-transporting ATPase subunit B;


Pssm-ID: 184448 [Multi-domain]  Cd Length: 673  Bit Score: 65.88  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   667 ENDIVTGltciaVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILhpgedflclegkdfnrrirne 746
Cdd:PRK14010  428 EDNEILG-----VIYLKDVIKDGLVERFRELREMGIETVMCTGDNELTAATIAKEAGVD--------------------- 481
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   747 kgeieqeridkiwpklRVLARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKADVGFAMGiAGTDVAKEAS 826
Cdd:PRK14010  482 ----------------RFVAECKPEDKINVIR-----EEQAKGHIVAMTGDGTNDAPALAEANVGLAMN-SGTMSAKEAA 539
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 48255947   827 DIILTDDNFTSIVKAVMWGRNVYDSISKFLQFQLTVNV 864
Cdd:PRK14010  540 NLIDLDSNPTKLMEVVLIGKQLLMTRGSLTTFSIANDI 577
PLN03190 PLN03190
aminophospholipid translocase; Provisional
420-718 2.38e-10

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 65.30  E-value: 2.38e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   420 FIIGVTVLVVAVPEGLPLA---VTISLAYSvkkMMKDNNL----------VRHLDACETMGNATAICSDKTGTLTMNRMT 486
Cdd:PLN03190  394 FLMSVIVFQIMIPISLYISmelVRVGQAYF---MIRDDQMydeasnsrfqCRALNINEDLGQIKYVFSDKTGTLTENKME 470
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   487 VVQAYINEKHYKKVPEPEAIPPNILSYLVTGISVNCAYTSKILP---------PEKEGG----------------LPRHV 541
Cdd:PLN03190  471 FQCASIWGVDYSDGRTPTQNDHAGYSVEVDGKILRPKMKVKVDPqllelsksgKDTEEAkhvhdfflalaacntiVPIVV 550
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   542 GNKTECALLGLlldlkrDYQ------------------------------DVRNEIPEEALYKVYTFNSVRKSMSTVLKN 591
Cdd:PLN03190  551 DDTSDPTVKLM------DYQgespdeqalvyaaaaygfmliertsghiviDIHGERQRFNVLGLHEFDSDRKRMSVILGC 624
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947   592 SDGSYRIFSKGASEIIlkkcFKILSANGEAKVFRPrdrddiVKTVIEPMASEGLRTICLAFRDFPAGEPEpEWDNE---- 667
Cdd:PLN03190  625 PDKTVKVFVKGADTSM----FSVIDRSLNMNVIRA------TEAHLHTYSSLGLRTLVVGMRELNDSEFE-QWHFSfeaa 693
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 48255947   668 ---------------NDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAI 718
Cdd:PLN03190  694 staligraallrkvaSNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISI 759
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
587-809 5.34e-07

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Swiss:P24069. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteriztic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 459910 [Multi-domain]  Cd Length: 191  Bit Score: 51.43  E-value: 5.34e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    587 TVLKNSDGSYRIFSKGASEIILKKcfkilsANGEAKVFRPRDRDDIVKTVIEpmaseGLRTICLAFRDFPAGEPEPEWDN 666
Cdd:pfam00702   11 TLTDGEPVVTEAIAELASEHPLAK------AIVAAAEDLPIPVEDFTARLLL-----GKRDWLEELDILRGLVETLEAEG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    667 ENDIVTGLTCIAVVGIEDPVRPEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFnrrirne 746
Cdd:pfam00702   80 LTVVLVELLGVIALADELKLYPGAAEALKALKERGIKVAILTGDNPEAAEALLRLLGLDDYFDVVISGDDVGV------- 152
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 48255947    747 kgeieqeridkiwpklrvlARSSPTDKHTLVKgiidsTVSDQRQVVAVTGDGTNDGPALKKAD 809
Cdd:pfam00702  153 -------------------GKPKPEIYLAALE-----RLGVKPEEVLMVGDGVNDIPAAKAAG 191
Cof COG0561
Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport ...
688-834 4.12e-05

Hydroxymethylpyrimidine pyrophosphatase and other HAD family phosphatases [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440327 [Multi-domain]  Cd Length: 192  Bit Score: 45.90  E-value: 4.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  688 PEVPDAIKKCQRAGITVRMVTGDNINTARAIATKCGILHPgedFLCLEG---KDFNRRIRNEKGeIEQERIDKIWPKLR- 763
Cdd:COG0561   22 PRTKEALRRLREKGIKVVIATGRPLRSALPLLEELGLDDP---LITSNGaliYDPDGEVLYERP-LDPEDVREILELLRe 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947  764 ------VLARSSPT---------DK----HTLVK--GIidstvsDQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVA 822
Cdd:COG0561   98 hglhlqVVVRSGPGfleilpkgvSKgsalKKLAErlGI------PPEEVIAF-GDSGNDLEMLEAAGLGVAMGNA-PPEV 169
                        170
                 ....*....|..
gi 48255947  823 KEASDIIlTDDN 834
Cdd:COG0561  170 KAAADYV-TGSN 180
Hydrolase_3 pfam08282
haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like ...
743-841 1.30e-03

haloacid dehalogenase-like hydrolase; This family contains haloacid dehalogenase-like hydrolase enzymes.


Pssm-ID: 429897 [Multi-domain]  Cd Length: 255  Bit Score: 41.84  E-value: 1.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48255947    743 IRNEKGEIEQ--ERIDKIWPKLRVLARSSP---------TDKHTLVKGIIDSTVSDQRQVVAVtGDGTNDGPALKKADVG 811
Cdd:pfam08282  147 ILLDEEDLDEleKELKELFGSLITITSSGPgyleimpkgVSKGTALKALAKHLNISLEEVIAF-GDGENDIEMLEAAGLG 225
                           90       100       110
                   ....*....|....*....|....*....|
gi 48255947    812 FAMGIAgTDVAKEASDIILTDDNFTSIVKA 841
Cdd:pfam08282  226 VAMGNA-SPEVKAAADYVTDSNNEDGVAKA 254
Cof-subfamily TIGR00099
Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of ...
787-834 1.54e-03

Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; This subfamily of sequences falls within the Class-IIB subfamily (TIGR01484) of the Haloacid Dehalogenase superfamily of aspartate-nucleophile hydrolases. The use of the name "Cof" as an identifier here is arbitrary and refers to the E. coli Cof protein. This subfamily is notable for the large number of recent paralogs in many species. Listeria, for instance, has 12, Clostridium, Lactococcus and Streptococcus pneumoniae have 8 each, Enterococcus and Salmonella have 7 each, and Bacillus subtilus, Mycoplasma, Staphylococcus and E. coli have 6 each. This high degree of gene duplication is limited to the gamma proteobacteria and low-GC gram positive lineages. The profusion of genes in this subfamily is not coupled with a high degree of divergence, so it is impossible to determine an accurate phylogeny at the equivalog level. Considering the relationship of this subfamily to the other known members of the HAD-IIB subfamily (TIGR01484), sucrose and trehalose phosphatases and phosphomannomutase, it seems a reasonable hypothesis that these enzymes act on phosphorylated sugars. Possibly the diversification of genes in this subfamily represents the diverse sugars and polysaccharides that various bacteria find in their biological niches. The members of this subfamily are restricted almost exclusively to bacteria (one sequences from S. pombe scores above trusted, while another is between trusted and noise). It is notable that no archaea are found in this group, the closest relations to the archaea found here being two Deinococcus sequences. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 272905 [Multi-domain]  Cd Length: 256  Bit Score: 41.87  E-value: 1.54e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 48255947    787 DQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 834
Cdd:TIGR00099  203 SLEDVIAF-GDGMNDIEMLEAAGYGVAMGNA-DEELKALADYV-TDSN 247
HAD_Pase cd07516
phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the ...
787-834 6.97e-03

phosphatase, similar to Escherichia coli Cof and Thermotoga maritima TM0651; belongs to the haloacid dehalogenase-like superfamily; Escherichia coli Cof is involved in the hydrolysis of HMP-PP (4-amino-2-methyl-5-hydroxymethylpyrimidine pyrophosphate, an intermediate in thiamin biosynthesis), Cof also has phosphatase activity against the coenzymes pyridoxal phosphate (PLP) and FMN. Thermotoga maritima TM0651 acts as a phosphatase with a phosphorylated carbohydrate molecule as a possible substrate. Escherichia coli YbhA is also a member of this family and catalyzes the dephosphorylation of PLP, YbhA can also hydrolyze erythrose-4-phosphate and fructose-1,6-bis-phosphate. Members of this family belong to the haloacid dehalogenase-like (HAD) hydrolases, a large superfamily of diverse enzymes that catalyze carbon or phosphoryl group transfer reactions on a range of substrates, using an active site aspartate in nucleophilic catalysis. Members of this superfamily include 2-L-haloalkanoic acid dehalogenase, azetidine hydrolase, phosphonoacetaldehyde hydrolase, phosphoserine phosphatase, phosphomannomutase, P-type ATPases and many others. HAD hydrolases are found in all three kingdoms of life, and most genomes are predicted to contain multiple HAD-like proteins. Members possess a highly conserved alpha/beta core domain, and many also possess a small cap domain, the fold and function of which is variable. HAD hydrolases are sometimes referred to as belonging to the DDDD superfamily of phosphohydrolases.


Pssm-ID: 319818 [Multi-domain]  Cd Length: 253  Bit Score: 39.50  E-value: 6.97e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 48255947  787 DQRQVVAVtGDGTNDGPALKKADVGFAMGIAgTDVAKEASDIIlTDDN 834
Cdd:cd07516  198 SLEEVIAF-GDNENDLSMLEYAGLGVAMGNA-IDEVKEAADYV-TLTN 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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