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Conserved domains on  [gi|48717241|ref|NP_001001661|]
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zinc finger protein 425 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003677|GO:0008270|GO:0005515|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|8183940|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-64 2.54e-22

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.73  E-value: 2.54e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 48717241      9 VTFDDVALYFSEQEWEILEKWQKQMYKQEMKTNYETLDSLGYAFSKPDLITWMEQG 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQG 56
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-731 4.09e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 4.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 355 KRPFHCPECGRSFSRKAALKTHQRTHSEEKPFSCGECGRKFIYK--IKLDEHIRVHTGEKPFSC---------------- 416
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNskslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 417 PECNKSFRLKRSLKAHGLQHIGKRPFQCPECS----------RGFFWRNAMRAHQRLHSeqkPFPCAECGKRFTRPSKLA 486
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSisnlrnnplpGNNSSSVNTPQSNSLHP---PLPANSLSKDPSSNLSLL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 487 CHTRVHDRQKEFPCGECKKTFSQQSRLTQHLKVHTTEKPFSCAECGRSFRRRAHLTEHTRLHSGEEPFQCPECDKSFSWK 566
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 567 ASMK------FHQRMHRD-EKPFACGECDKTYTHQSQLTEHLR--LHSGE--KPYQCPE--CEKTFRLKGNLKSHLLQHS 633
Cdd:COG5048 268 ASSQssspneSDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 634 GQKPFSCV-------------MCGKSFTQQYRLTEHIRVHSGEKPFQCPECDKSYCirgsLKVHLYKHSGERP--FQCPE 698
Cdd:COG5048 348 SISPAKEKllnssskfspllnNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSN----LSLHIITHLSFRPynCKNPP 423

                       410       420       430
                ....*....|....*....|....*....|...
gi 48717241 699 CGKGFLQKRSLKAHLCLHSGERPFSCDECGRSF 731
Cdd:COG5048 424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 270-353 1.96e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 270 GQRPYPCP--ECDKTFRYRANLKKHLcLHrgerpfccGECGRAFVQQCELTEHLRLHSGEKPFQCPQCDRCFRLKRGMKV 347
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 48717241 348 HLTqHS 353
Cdd:COG5189 417 HRK-HS 421
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-64 2.54e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.73  E-value: 2.54e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 48717241      9 VTFDDVALYFSEQEWEILEKWQKQMYKQEMKTNYETLDSLGYAFSKPDLITWMEQG 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQG 56
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-49 1.30e-14

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 68.27  E-value: 1.30e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 48717241     9 VTFDDVALYFSEQEWEILEKWQKQMYKQEMKTNYETLDSLG 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 9-48 4.03e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 66.80  E-value: 4.03e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 48717241   9 VTFDDVALYFSEQEWEILEKWQKQMYKQEMKTNYETLDSL 48
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-731 4.09e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 4.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 355 KRPFHCPECGRSFSRKAALKTHQRTHSEEKPFSCGECGRKFIYK--IKLDEHIRVHTGEKPFSC---------------- 416
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNskslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 417 PECNKSFRLKRSLKAHGLQHIGKRPFQCPECS----------RGFFWRNAMRAHQRLHSeqkPFPCAECGKRFTRPSKLA 486
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSisnlrnnplpGNNSSSVNTPQSNSLHP---PLPANSLSKDPSSNLSLL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 487 CHTRVHDRQKEFPCGECKKTFSQQSRLTQHLKVHTTEKPFSCAECGRSFRRRAHLTEHTRLHSGEEPFQCPECDKSFSWK 566
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 567 ASMK------FHQRMHRD-EKPFACGECDKTYTHQSQLTEHLR--LHSGE--KPYQCPE--CEKTFRLKGNLKSHLLQHS 633
Cdd:COG5048 268 ASSQssspneSDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 634 GQKPFSCV-------------MCGKSFTQQYRLTEHIRVHSGEKPFQCPECDKSYCirgsLKVHLYKHSGERP--FQCPE 698
Cdd:COG5048 348 SISPAKEKllnssskfspllnNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSN----LSLHIITHLSFRPynCKNPP 423

                       410       420       430
                ....*....|....*....|....*....|...
gi 48717241 699 CGKGFLQKRSLKAHLCLHSGERPFSCDECGRSF 731
Cdd:COG5048 424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 270-353 1.96e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 270 GQRPYPCP--ECDKTFRYRANLKKHLcLHrgerpfccGECGRAFVQQCELTEHLRLHSGEKPFQCPQCDRCFRLKRGMKV 347
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 48717241 348 HLTqHS 353
Cdd:COG5189 417 HRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-423 3.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.02e-03
                          10        20
                  ....*....|....*....|...
gi 48717241   401 LDEHIRVHTGEKPFSCPECNKSF 423
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-339 9.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.91e-03
                          10        20
                  ....*....|....*....|....
gi 48717241   316 ELTEHLRLHSGEKPFQCPQCDRCF 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
9-64 2.54e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.73  E-value: 2.54e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 48717241      9 VTFDDVALYFSEQEWEILEKWQKQMYKQEMKTNYETLDSLGYAFSKPDLITWMEQG 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQG 56
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-49 1.30e-14

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 68.27  E-value: 1.30e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 48717241     9 VTFDDVALYFSEQEWEILEKWQKQMYKQEMKTNYETLDSLG 49
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 9-48 4.03e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 66.80  E-value: 4.03e-14
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 48717241   9 VTFDDVALYFSEQEWEILEKWQKQMYKQEMKTNYETLDSL 48
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
355-731 4.09e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.50  E-value: 4.09e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 355 KRPFHCPECGRSFSRKAALKTHQRTHSEEKPFSCGECGRKFIYK--IKLDEHIRVHTGEKPFSC---------------- 416
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNskslplsnskassssl 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 417 PECNKSFRLKRSLKAHGLQHIGKRPFQCPECS----------RGFFWRNAMRAHQRLHSeqkPFPCAECGKRFTRPSKLA 486
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSisnlrnnplpGNNSSSVNTPQSNSLHP---PLPANSLSKDPSSNLSLL 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 487 CHTRVHDRQKEFPCGECKKTFSQQSRLTQHLKVHTTEKPFSCAECGRSFRRRAHLTEHTRLHSGEEPFQCPECDKSFSWK 566
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 567 ASMK------FHQRMHRD-EKPFACGECDKTYTHQSQLTEHLR--LHSGE--KPYQCPE--CEKTFRLKGNLKSHLLQHS 633
Cdd:COG5048 268 ASSQssspneSDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 634 GQKPFSCV-------------MCGKSFTQQYRLTEHIRVHSGEKPFQCPECDKSYCirgsLKVHLYKHSGERP--FQCPE 698
Cdd:COG5048 348 SISPAKEKllnssskfspllnNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSN----LSLHIITHLSFRPynCKNPP 423

                       410       420       430
                ....*....|....*....|....*....|...
gi 48717241 699 CGKGFLQKRSLKAHLCLHSGERPFSCDECGRSF 731
Cdd:COG5048 424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
320-537 6.74e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 6.74e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 320 HLRLHSGEKPFQCPQCDRCFRLKRGMKVH------LTQHSGKRPFH-CPECGRSFSRKAALKTHQRTHSeekpfscgecg 392
Cdd:COG5048 245 PSSLSSSDSSSSASESPRSSLPTASSQSSspnesdSSSEKGFSLPIkSKQCNISFSRSSPLTRHLRSVN----------- 313

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 393 rkfiykikldehirvHTGE--KPFSCPE--CNKSFRLKRSLKAHGLQHIGKRPFQCPECSRGF-------FWRNAMRAHQ 461
Cdd:COG5048 314 ---------------HSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSkfspllnNEPPQSLQQY 378

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 462 RLHSEQKPFPCA--ECGKRFTRPSKLACHTRVH--DRQKEFPCGECKKTFSQQSRLTQHLKVHTTEKPFSCAECGRSFRR 537
Cdd:COG5048 379 KDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHlsFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 606-689 2.79e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.79e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 606 GEKPYQCP--ECEKTFRLKGNLKSHLLqHSGQKPFSCVMCGKSFTQQYRLTEhirvhsgeKPFQCPECDKSYCIRGSLKV 683
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSPEKMNIFSAKD--------KPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 48717241 684 HLyKHS 689
Cdd:COG5189 417 HR-KHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 578-633 1.35e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.35e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 48717241 578 DEKPFACG--ECDKTYTHQSQLTEHlRLH--------------------SGEKPYQCPECEKTFRLKGNLKSHlLQHS 633
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 270-353 1.96e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 270 GQRPYPCP--ECDKTFRYRANLKKHLcLHrgerpfccGECGRAFVQQCELTEHLRLHSGEKPFQCPQCDRCFRLKRGMKV 347
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                ....*.
gi 48717241 348 HLTqHS 353
Cdd:COG5189 417 HRK-HS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 410-492 8.18e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 8.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48717241 410 GEKPFSCP--ECNKSFRLKRSLKAHGLQ-HIGKRPFQCPecsrgffwrnAMRAHQRLHSEQKPFPCAECGKRFTRPSKLA 486
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENP----------SPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ....*.
gi 48717241 487 CHtRVH 492
Cdd:COG5189 416 YH-RKH 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
578-640 1.30e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 1.30e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 48717241 578 DEKPFACGECDKTYTHQSQLTEHLRLHSGEKPYQC--PECEKTFRLKGNLKSHLLQHSGQKPFSC 640
Cdd:COG5048  30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
401-423 3.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.02e-03
                          10        20
                  ....*....|....*....|...
gi 48717241   401 LDEHIRVHTGEKPFSCPECNKSF 423
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 358-380 3.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.76e-03
                          10        20
                  ....*....|....*....|...
gi 48717241   358 FHCPECGRSFSRKAALKTHQRTH 380
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
680-705 4.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.01e-03
                          10        20
                  ....*....|....*....|....*.
gi 48717241   680 SLKVHLYKHSGERPFQCPECGKGFLQ 705
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
652-675 5.23e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.23e-03
                          10        20
                  ....*....|....*....|....
gi 48717241   652 RLTEHIRVHSGEKPFQCPECDKSY 675
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
597-619 5.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.66e-03
                          10        20
                  ....*....|....*....|...
gi 48717241   597 LTEHLRLHSGEKPYQCPECEKTF 619
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
540-564 6.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.69e-03
                          10        20
                  ....*....|....*....|....*
gi 48717241   540 HLTEHTRLHSGEEPFQCPECDKSFS 564
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
316-339 9.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.91e-03
                          10        20
                  ....*....|....*....|....
gi 48717241   316 ELTEHLRLHSGEKPFQCPQCDRCF 339
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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