NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|50541961|ref|NP_001002294|]
View 

flavin-containing monooxygenase 3 isoform a [Homo sapiens]

Protein Classification

flavin-binding monooxygenase-like family protein( domain architecture ID 1000557)

flavin-binding monooxygenase-like family protein; such as flavin-containing monooxygenases (FMOs) that catalyze the monooxygenation of a variety of substrates

EC:  1.14.13.-
Gene Ontology:  GO:0004497

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 992.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961     2 GKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNF 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961    82 MHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   162 GLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFGT 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   242 FLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEG 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   322 IDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPS 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   402 MEDMMNDINEKMEKKRKWFG--KSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQW 479
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGdsQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 50541961   480 PGARNAILTQWDRSLKPMQTRVVGRLQKPCFFFhWLKLFAIPILLIAVFLVL 531
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSF-TLKIFGLPVVLVAIFLIL 531
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 992.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961     2 GKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNF 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961    82 MHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   162 GLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFGT 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   242 FLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEG 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   322 IDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPS 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   402 MEDMMNDINEKMEKKRKWFG--KSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQW 479
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGdsQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 50541961   480 PGARNAILTQWDRSLKPMQTRVVGRLQKPCFFFhWLKLFAIPILLIAVFLVL 531
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSF-TLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-394 2.36e-72

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 236.30  E-value: 2.36e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   5 VAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWkfsdhaeegRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHN 84
Cdd:COG2072   9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTW---------RDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961  85 SKIQEYIIAFAKEKNLLKYIQFKTFVSSVnkHPDfATTGQWDVTTErDGKKESAvfDAVMVCSGHHVYPNLPkeSFPGLN 164
Cdd:COG2072  80 DEILAYLEAYADKFGLRRPIRFGTEVTSA--RWD-EADGRWTVTTD-DGETLTA--RFVVVATGPLSRPKIP--DIPGLE 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961 165 HFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRvwdNGYPWDMllvTRFGTFLK 244
Cdd:COG2072 152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPER---GRPANYLG 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961 245 NNLPTAISD----WLYVKQMNARFKHENYG-LMPLNGVLRKEPVFNDELPASILCGIVS-VKPNVKEFTETSAIFEDGTi 318
Cdd:COG2072 226 LEAPPALNRrdarAWLRRLLRAQVKDPELGlLTPDYPPGCKRPLLSTDYYEALRRGNVElVTGGIERITEDGVVFADGT- 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961 319 FEGIDCVIFATGYSFAYPFLDESIIKSRN--NEIILFKGV----FPPLlekstiAVIGFVQSLGAA--IPTVDLQSRWAA 390
Cdd:COG2072 305 EHEVDVIVWATGFRADLPWLAPLDVRGRDgrSGPRAYLGVvvpgFPNL------FFLGPNSPSGHSslTLGAERQARYIA 378


                ....
gi 50541961 391 QVIK 394
Cdd:COG2072 379 RLIA 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-440 1.64e-41

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 155.02  E-value: 1.64e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961    3 KKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEG-----------RASIYKSVFSNSSKEMMCFPD 71
Cdd:PLN02172  11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYRD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   72 FPFPDDFPNFMHNSK-------IQEYIIAFAKEKNLLKYIQFKTFVSSVNkhpdfATTGQWDVTTER-DGKKESAVFDAV 143
Cdd:PLN02172  91 FPFVPRFDDESRDSRrypshreVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNsGGFSKDEIFDAV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961  144 MVCSGHHVYPNLPKesFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSgswvmsr 223
Cdd:PLN02172 166 VVCNGHYTEPNVAH--IPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASRA------- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961  224 vwdngypwdmllvTRFGTFLK-----NNLptaisdWLYVKqmnARFKHEnyglmplngvlrkepvfndelpasilcgivs 298
Cdd:PLN02172 237 -------------SESDTYEKlpvpqNNL------WMHSE---IDTAHE------------------------------- 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961  299 vkpnvkeftETSAIFEDGTIFEGiDCVIFATGYSFAYPFLDES-IIKSRNNEI-ILFKGVFPPLLEKStIAVIGfVQSLG 376
Cdd:PLN02172 264 ---------DGSIVFKNGKVVYA-DTIVHCTGYKYHFPFLETNgYMRIDENRVePLYKHVFPPALAPG-LSFIG-LPAMG 331

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961  377 AAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKK------RKWFGKSETIQTDYIVYMDELSSF 440
Cdd:PLN02172 332 IQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYASLealgipKRYTHKLGKIQSEYLNWIAEECGC 401
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 2-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 992.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961     2 GKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNF 81
Cdd:pfam00743   1 AKKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961    82 MHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFP 161
Cdd:pfam00743  81 MHNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   162 GLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFGT 241
Cdd:pfam00743 161 GIEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   242 FLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEG 321
Cdd:pfam00743 241 FLRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEED 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   322 IDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPS 401
Cdd:pfam00743 321 IDVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPS 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   402 MEDMMNDINEKMEKKRKWFG--KSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQW 479
Cdd:pfam00743 401 QSEMMAEINKRQEKKIKRFGdsQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKW 480

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 50541961   480 PGARNAILTQWDRSLKPMQTRVVGRLQKPCFFFhWLKLFAIPILLIAVFLVL 531
Cdd:pfam00743 481 EGARNAILTQWDRILKPLKTRVVEKSSSPASSF-TLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-394 2.36e-72

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 236.30  E-value: 2.36e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   5 VAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWkfsdhaeegRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHN 84
Cdd:COG2072   9 VVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTW---------RDNRYPGLRLDTPSHLYSLPFFPNWSDDPDFPTG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961  85 SKIQEYIIAFAKEKNLLKYIQFKTFVSSVnkHPDfATTGQWDVTTErDGKKESAvfDAVMVCSGHHVYPNLPkeSFPGLN 164
Cdd:COG2072  80 DEILAYLEAYADKFGLRRPIRFGTEVTSA--RWD-EADGRWTVTTD-DGETLTA--RFVVVATGPLSRPKIP--DIPGLE 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961 165 HFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRvwdNGYPWDMllvTRFGTFLK 244
Cdd:COG2072 152 DFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPR---PNYDPER---GRPANYLG 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961 245 NNLPTAISD----WLYVKQMNARFKHENYG-LMPLNGVLRKEPVFNDELPASILCGIVS-VKPNVKEFTETSAIFEDGTi 318
Cdd:COG2072 226 LEAPPALNRrdarAWLRRLLRAQVKDPELGlLTPDYPPGCKRPLLSTDYYEALRRGNVElVTGGIERITEDGVVFADGT- 304

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961 319 FEGIDCVIFATGYSFAYPFLDESIIKSRN--NEIILFKGV----FPPLlekstiAVIGFVQSLGAA--IPTVDLQSRWAA 390
Cdd:COG2072 305 EHEVDVIVWATGFRADLPWLAPLDVRGRDgrSGPRAYLGVvvpgFPNL------FFLGPNSPSGHSslTLGAERQARYIA 378


                ....
gi 50541961 391 QVIK 394
Cdd:COG2072 379 RLIA 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-440 1.64e-41

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 155.02  E-value: 1.64e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961    3 KKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEG-----------RASIYKSVFSNSSKEMMCFPD 71
Cdd:PLN02172  11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYRD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   72 FPFPDDFPNFMHNSK-------IQEYIIAFAKEKNLLKYIQFKTFVSSVNkhpdfATTGQWDVTTER-DGKKESAVFDAV 143
Cdd:PLN02172  91 FPFVPRFDDESRDSRrypshreVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNsGGFSKDEIFDAV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961  144 MVCSGHHVYPNLPKesFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSgswvmsr 223
Cdd:PLN02172 166 VVCNGHYTEPNVAH--IPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIASRA------- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961  224 vwdngypwdmllvTRFGTFLK-----NNLptaisdWLYVKqmnARFKHEnyglmplngvlrkepvfndelpasilcgivs 298
Cdd:PLN02172 237 -------------SESDTYEKlpvpqNNL------WMHSE---IDTAHE------------------------------- 263

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961  299 vkpnvkeftETSAIFEDGTIFEGiDCVIFATGYSFAYPFLDES-IIKSRNNEI-ILFKGVFPPLLEKStIAVIGfVQSLG 376
Cdd:PLN02172 264 ---------DGSIVFKNGKVVYA-DTIVHCTGYKYHFPFLETNgYMRIDENRVePLYKHVFPPALAPG-LSFIG-LPAMG 331

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961  377 AAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKK------RKWFGKSETIQTDYIVYMDELSSF 440
Cdd:PLN02172 332 IQFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINAWYASLealgipKRYTHKLGKIQSEYLNWIAEECGC 401
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
89-353 4.08e-14

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 73.03  E-value: 4.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961    89 EYIIAFAKEKNLLkyIQFKTFVSSVNKHPDFATtgqwdVTTERDgkkesaVFDA--VMVCSGHHVYPNLPkesfpglnHF 166
Cdd:pfam13738  79 EYLRRVADHFELP--INLFEEVTSVKKEDDGFV-----VTTSKG------TYQAryVIIATGEFDFPNKL--------GV 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   167 KGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWvmsrvwdngypwdmllvtrfgtflkNN 246
Cdd:pfam13738 138 PELPKHYSYVKDFHPYAGQKVVVIGGYNSAVDAALELVRKGARVTVLYRGSEW-------------------------ED 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961   247 LPTAISDWL--YVKQmnaRFKHenyglmplngVLRKEPV---FNDElpasilcgivsvkpnVKEFTETSAI----FEDGT 317
Cdd:pfam13738 193 RDSDPSYSLspDTLN---RLEE----------LVKNGKIkahFNAE---------------VKEITEVDVSykvhTEDGR 244

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 50541961   318 IFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILF 353
Cdd:pfam13738 245 KVTSNDDPILATGYHPDLSFLKKGLFELDEDGRPVL 280
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-40 5.62e-06

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 48.68  E-value: 5.62e-06
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 50541961   3 KKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGL 40
Cdd:COG1232   2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGL 39
PRK07233 PRK07233
hypothetical protein; Provisional
 4-40 4.33e-05

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 46.03  E-value: 4.33e-05
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 50541961    4 KVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGL 40
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGL 37
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-67 5.44e-05

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 41.36  E-value: 5.44e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 50541961     7 IIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGL---WKFSDHAEEGRASIYKSVFSNSSKEMM 67
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNaysYRVPGYVFDYGAHIFHGSDEPNVRDLL 64
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
127-210 5.85e-05

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 45.11  E-value: 5.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50541961 127 VTTErDGKKESAvfDAVMVCSGhhVYPNLPKesFPGLNHFKGKcfhsrdykepGV----------FNGKRVLVVGLGNSG 196
Cdd:COG0492  91 VTTD-DGTEYEA--KAVIIATG--AGPRKLG--LPGEEEFEGR----------GVsycatcdgffFRGKDVVVVGGGDSA 153

                        90
                ....*....|....
gi 50541961 197 CDIATELSRTAEQV 210
Cdd:COG0492 154 LEEALYLTKFASKV 167
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 2-40 7.51e-05

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 45.15  E-value: 7.51e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 50541961    2 GKKVAIIGAGVSGLAsirsCLEE----GLEPTCFEKSNDIGGL 40
Cdd:PRK12810 143 GKKVAVVGSGPAGLA----AADQlaraGHKVTVFERADRIGGL 181
COG3380 COG3380
Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];
1-39 2.63e-04

Predicted NAD/FAD-dependent oxidoreductase [General function prediction only];


Pssm-ID: 442607 [Multi-domain]  Cd Length: 331  Bit Score: 43.33  E-value: 2.63e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 50541961   1 MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGG 39
Cdd:COG3380   2 SMPDIAIIGAGIAGLAAARALQDAGHEVTVFEKSRGVGG 40
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
2-39 3.39e-04

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 42.99  E-value: 3.39e-04
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 50541961   2 GKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGG 39
Cdd:COG1231   7 GKDVVIVGAGLAGLAAARELRKAGLDVTVLEARDRVGG 44
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 2-43 3.81e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 43.20  E-value: 3.81e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 50541961    2 GKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKF 43
Cdd:PRK12769 327 DKRVAIIGAGPAGLACADVLARNGVAVTVYDRHPEIGGLLTF 368
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 2-34 4.74e-04

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 42.76  E-value: 4.74e-04
                        10        20        30
                ....*....|....*....|....*....|...
gi 50541961   2 GKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKS 34
Cdd:COG0771   4 GKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDR 36
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 2-40 7.79e-04

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 42.04  E-value: 7.79e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 50541961   2 GKKVAIIGAGVSGLAsirsC----LEEGLEPTCFEKSNDIGGL 40
Cdd:COG0493 121 GKKVAVVGSGPAGLA----AayqlARAGHEVTVFEALDKPGGL 159
PRK07208 PRK07208
hypothetical protein; Provisional
 1-40 2.01e-03

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 40.64  E-value: 2.01e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 50541961    1 MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGL 40
Cdd:PRK07208   3 NKKSVVIIGAGPAGLTAAYELLKRGYPVTVLEADPVVGGI 42
PRK11749 PRK11749
dihydropyrimidine dehydrogenase subunit A; Provisional
 2-40 9.78e-03

dihydropyrimidine dehydrogenase subunit A; Provisional


Pssm-ID: 236967 [Multi-domain]  Cd Length: 457  Bit Score: 38.62  E-value: 9.78e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 50541961    2 GKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGL 40
Cdd:PRK11749 140 GKKVAVIGAGPAGLTAAHRLARKGYDVTIFEARDKAGGL 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH