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Conserved domains on  [gi|53832003|ref|NP_001005353|]
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adenylate kinase 4, mitochondrial isoform a [Homo sapiens]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11995178)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
10-188 2.97e-100

Adenylate kinase;


:

Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 288.44  E-value: 2.97e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    10 ILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELE-NRRGQHWLLD 88
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEqNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    89 GFPRTLGQAEALDK----ICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKP 164
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 53832003   165 EAVAARLRQYKDVAKPVIELYKSR 188
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
10-188 2.97e-100

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 288.44  E-value: 2.97e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    10 ILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELE-NRRGQHWLLD 88
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEqNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    89 GFPRTLGQAEALDK----ICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKP 164
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 53832003   165 EAVAARLRQYKDVAKPVIELYKSR 188
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 7-211 6.92e-100

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 288.75  E-value: 6.92e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003     7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQH-- 84
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEng 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    85 WLLDGFPRTLGQAEALDKICE--VDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDD 162
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 53832003   163 KPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT-ETNKIWPYVYTLFS 211
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 7-197 1.85e-83

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 246.96  E-value: 1.85e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLM---MSELENRRGq 83
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVkerLAQPDCANG- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003  84 hWLLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQ 158
Cdd:COG0563  81 -FILDGFPRTVAQAEALDELLAelgikLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQ 159

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 53832003 159 QEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT 197
Cdd:COG0563 160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 7-199 4.34e-81

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 240.22  E-value: 4.34e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENR-RGQHW 85
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPdCKKGF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003  86 LLDGFPRTLGQAEALDKICE----VDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLdfnpphvhGIDDVTGEPLVQQED 161
Cdd:cd01428  81 ILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSD 152

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 53832003 162 DKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET 199
Cdd:cd01428 153 DNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
adk PRK00279
adenylate kinase; Reviewed
 6-197 5.11e-78

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 233.12  E-value: 5.11e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    6 LRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELEN---RRG 82
Cdd:PRK00279   1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQpdcKNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   83 qhWLLDGFPRTLGQAEALDKIC-----EVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLV 157
Cdd:PRK00279  81 --FLLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELI 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 53832003  158 QQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT 197
Cdd:PRK00279 159 QRADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGT 198
 
Name Accession Description Interval E-value
ADK pfam00406
Adenylate kinase;
10-188 2.97e-100

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 288.44  E-value: 2.97e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    10 ILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELE-NRRGQHWLLD 88
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEqNDCKNGFLLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    89 GFPRTLGQAEALDK----ICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDDKP 164
Cdd:pfam00406  81 GFPRTVPQAEALEEllerGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDDNE 160

                         170       180
                  ....*....|....*....|....
gi 53832003   165 EAVAARLRQYKDVAKPVIELYKSR 188
Cdd:pfam00406 161 ETVKKRLETYHKQTKPLIDYYKKK 184
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 7-211 6.92e-100

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 288.75  E-value: 6.92e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003     7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQH-- 84
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEng 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    85 WLLDGFPRTLGQAEALDKICE--VDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDD 162
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEepIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQREDD 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 53832003   163 KPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT-ETNKIWPYVYTLFS 211
Cdd:TIGR01351 161 TEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNgPIDEVWKRILEALK 210
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 7-197 1.85e-83

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 246.96  E-value: 1.85e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLM---MSELENRRGq 83
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVkerLAQPDCANG- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003  84 hWLLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQ 158
Cdd:COG0563  81 -FILDGFPRTVAQAEALDELLAelgikLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQ 159

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 53832003 159 QEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT 197
Cdd:COG0563 160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGE 198
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 7-199 4.34e-81

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 240.22  E-value: 4.34e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENR-RGQHW 85
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPdCKKGF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003  86 LLDGFPRTLGQAEALDKICE----VDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLdfnpphvhGIDDVTGEPLVQQED 161
Cdd:cd01428  81 ILDGFPRTVDQAEALDELLDegikPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQRSD 152

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 53832003 162 DKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET 199
Cdd:cd01428 153 DNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGD 190
adk PRK00279
adenylate kinase; Reviewed
 6-197 5.11e-78

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 233.12  E-value: 5.11e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    6 LRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELEN---RRG 82
Cdd:PRK00279   1 MRLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERLAQpdcKNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   83 qhWLLDGFPRTLGQAEALDKIC-----EVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLV 157
Cdd:PRK00279  81 --FLLDGFPRTIPQAEALDEMLkelgiKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELI 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 53832003  158 QQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGT 197
Cdd:PRK00279 159 QRADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGT 198
PLN02674 PLN02674
adenylate kinase
 7-193 9.53e-53

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 170.07  E-value: 9.53e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQH-W 85
Cdd:PLN02674  33 RLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAMKKPSCQKgF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   86 LLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQE 160
Cdd:PLN02674 113 ILDGFPRTVVQAQKLDEMLAkqgakIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTGEPLIQRK 192

                        170       180       190
                 ....*....|....*....|....*....|...
gi 53832003  161 DDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQ 193
Cdd:PLN02674 193 DDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVAN 225
PRK14530 PRK14530
adenylate kinase; Provisional
 1-203 6.21e-48

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 156.87  E-value: 6.21e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    1 MASKllRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKAS-----TEVGeMAKQYIEKSLLVPDHVITRLMMS 75
Cdd:PRK14530   1 MSQP--RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRANKQMDisdmdTEYD-TPGEYMDAGELVPDAVVNEIVEE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   76 ELENRRGqhWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEP 155
Cdd:PRK14530  78 ALSDADG--FVLDGYPRNLEQAEYLESITDLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGE 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 53832003  156 LVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET-NKIW 203
Cdd:PRK14530 156 LIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTpDEVW 204
PLN02842 PLN02842
nucleotide kinase
 9-187 5.56e-40

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 143.08  E-value: 5.56e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    9 VILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSEL--ENRRGQHWL 86
Cdd:PLN02842   1 MISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLsrEDAKEKGWL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   87 LDGFPRTLGQAEALDKI-CEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHvhgiDDVTGEPLVQQEDDKPE 165
Cdd:PLN02842  81 LDGYPRSFAQAQSLEKLkIRPDIFILLDVPDEILIDRCVGRRLDPVTGKIYHIKNFPPE----SEEIKARLITRPDDTEE 156

                        170       180
                 ....*....|....*....|..
gi 53832003  166 AVAARLRQYKDVAKPVIELYKS 187
Cdd:PLN02842 157 KVKARLQIYKKNAEAILSTYSD 178
PRK14526 PRK14526
adenylate kinase; Provisional
 6-185 5.30e-39

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 133.82  E-value: 5.30e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    6 LRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLM---MSELENRRg 82
Cdd:PRK14526   1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVedkINTIKNND- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   83 qHWLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQEDD 162
Cdd:PRK14526  80 -NFILDGFPRNINQAKALDKFLPNIKIINFLIDEELLIKRLSGRRICKSCNNIFNIYTLPTKEKGICDVCKGDLYQRKDD 158

                        170       180
                 ....*....|....*....|...
gi 53832003  163 KPEAVAARLRQYKDVAKPVIELY 185
Cdd:PRK14526 159 KEESLKTRLQEYKLQTKPLIEFY 181
PLN02459 PLN02459
probable adenylate kinase
 9-194 2.46e-36

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 128.43  E-value: 2.46e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    9 VILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELEN--RRGQH-W 85
Cdd:PLN02459  33 VFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAgeEEGESgF 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   86 LLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDR-LSRRwIHPPSGRVYNL-DFNPPHVHGIDDVTGEPL------- 156
Cdd:PLN02459 113 ILDGFPRTVRQAEILEGVTDIDLVVNLKLREEVLVEKcLGRR-ICSECGKNFNVaDIDLKGEDGRPGIVMPPLlpppeca 191

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 53832003  157 ---VQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQF 194
Cdd:PLN02459 192 sklITRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEF 232
adk PRK02496
adenylate kinase; Provisional
 7-199 2.47e-34

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 121.01  E-value: 2.47e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQH-W 85
Cdd:PRK02496   3 RLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERLQQPDAANgW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   86 LLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRRwihppsGRvynldfnpphvhgiddvtgeplvqqE 160
Cdd:PRK02496  83 ILDGFPRKVTQAAFLDELLQeigqsGERVVNLDVPDDVVVERLLAR------GR-------------------------K 131

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 53832003  161 DDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET 199
Cdd:PRK02496 132 DDTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTIDGNQS 170
PRK14527 PRK14527
adenylate kinase; Provisional
 7-199 3.03e-33

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 118.35  E-value: 3.03e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    7 RAVI-LGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQHW 85
Cdd:PRK14527   7 KVVIfLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   86 LLDGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRRwihppsGRvynldfnpphvhgiddvtgepLVQQE 160
Cdd:PRK14527  87 IFDGFPRTLAQAEALDRLLEelgarLLAVVLLEVPDEELIRRIVER------AR---------------------QEGRS 139

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 53832003  161 DDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET 199
Cdd:PRK14527 140 DDNEETVRRRQQVYREQTQPLVDYYEARGHLKRVDGLGT 178
PRK14531 PRK14531
adenylate kinase; Provisional
 1-191 8.73e-33

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 116.83  E-value: 8.73e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    1 MASKLLravILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENR 80
Cdd:PRK14531   1 MKQRLL---FLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKAL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   81 RGQHWLLDGFPRTLGQAEALDKicevdLVISLNIPFETlkdrlsrrwihppsgrVYNLDFNpphvhgiDDVTGEPLVQ-- 158
Cdd:PRK14531  78 NSGGWLLDGFPRTVAQAEALEP-----LLEELKQPIEA----------------VVLLELD-------DAVLIERLLArg 129

                        170       180       190
                 ....*....|....*....|....*....|...
gi 53832003  159 QEDDKPEAVAARLRQYKDVAKPVIELYKSRGVL 191
Cdd:PRK14531 130 RADDNEAVIRNRLEVYREKTAPLIDHYRQRGLL 162
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 10-193 4.24e-32

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 115.30  E-value: 4.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    10 ILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRL----MMSELENRRGqhW 85
Cdd:TIGR01360   8 IVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLlkdaMVAALGTSKG--F 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    86 LLDGFPRTLGQAEALD-KICEVDLVISLNIPFETLKDRLSRRwiHPPSGRVynldfnpphvhgiddvtgeplvqqeDDKP 164
Cdd:TIGR01360  86 LIDGYPREVKQGEEFErRIGPPTLVLYFDCSEDTMVKRLLKR--AETSGRV-------------------------DDNE 138

                         170       180
                  ....*....|....*....|....*....
gi 53832003   165 EAVAARLRQYKDVAKPVIELYKSRGVLHQ 193
Cdd:TIGR01360 139 KTIKKRLETYYKATEPVIAYYETKGKLRK 167
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 10-211 9.32e-32

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 114.39  E-value: 9.32e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    10 ILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKAS-TEVGEMAKQYIEKSLLVPDHVITRLMMSEL-ENRRGQHWLL 87
Cdd:TIGR01359   4 VLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREgSENGSLIESYIKEGKIVPSEVTVELLKKAIqEDGSSKKFLI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    88 DGFPRTLGQAEALDKI----CEVDLVISLNIPFETLKDRLSRRwiHPPSGRVynldfnpphvhgiddvtgeplvqqeDDK 163
Cdd:TIGR01359  84 DGFPRNEENLEAWEKLmdnkVNFKFVLFFDCPEETMIKRLLKR--GQTSGRV-------------------------DDN 136

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 53832003   164 PEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET-NKIWPYVYTLFS 211
Cdd:TIGR01359 137 IETLKKRFRTYNEETLPIIEHFENKGKVKEINAEGSvEEVFEDVEKIFA 185
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 6-190 5.67e-30

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 111.04  E-value: 5.67e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    6 LRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQH- 84
Cdd:PTZ00088   7 LKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKVTDDCf 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   85 --WLLDGFPRTLGQAEALDKICEVDLVISLNIPFETLKDRLSRRWIHPPSGRVYNL------DFNPPHV---HGIDDVTG 153
Cdd:PTZ00088  87 kgFILDGFPRNLKQCKELGKITNIDLFVNIYLPRNILIKKLLGRRICNTCNRNFNIahirsdPYDMPPIlppADCEGCKG 166

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 53832003  154 EP-LVQQEDDKPEAVAARLRQYKDVAKPVIELYKSRGV 190
Cdd:PTZ00088 167 NPkLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK13808 PRK13808
adenylate kinase; Provisional
 6-188 6.47e-30

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 113.06  E-value: 6.47e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    6 LRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRG-QH 84
Cdd:PRK13808   1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRIEQPDAaNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   85 WLLDGFPRTLGQAEALD-----KICEVDLVISLNIPFETLKDRLSRRwIHPPSGRvynldfnpphvhgiddvtGEPLvqQ 159
Cdd:PRK13808  81 FILDGFPRTVPQAEALDallkdKQLKLDAVVELRVNEGALLARVETR-VAEMRAR------------------GEEV--R 139

                        170       180
                 ....*....|....*....|....*....
gi 53832003  160 EDDKPEAVAARLRQYKDVAKPVIELYKSR 188
Cdd:PRK13808 140 ADDTPEVLAKRLASYRAQTEPLVHYYSEK 168
PRK14529 PRK14529
adenylate kinase; Provisional
 9-126 1.33e-28

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 107.11  E-value: 1.33e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    9 VILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQHWLLD 88
Cdd:PRK14529   4 LIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDGKNGWLLD 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 53832003   89 GFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRR 126
Cdd:PRK14529  84 GFPRNKVQAEKLWEALQkegmkLDYVIEILLPREVAKNRIMGR 126
PRK14528 PRK14528
adenylate kinase; Provisional
 7-199 1.47e-28

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 106.25  E-value: 1.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHV---ITRLMMSELENRRGq 83
Cdd:PRK14528   3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVvigIIKDRIREADCKNG- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   84 hWLLDGFPRTLGQAEALDKIC-----EVDLVISLNIPFETLKDRLSRRWIHppSGRvynldfnpphvhgiddvtgeplvq 158
Cdd:PRK14528  82 -FLLDGFPRTVEQADALDALLknegkSIDKAINLEVPDGELLKRLLGRAEI--EGR------------------------ 134

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 53832003  159 qEDDKPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSGTET 199
Cdd:PRK14528 135 -ADDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVNGVGS 174
PRK14532 PRK14532
adenylate kinase; Provisional
 9-196 2.07e-28

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 105.67  E-value: 2.07e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    9 VILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSEL-ENRRGQHWLL 87
Cdd:PRK14532   4 ILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLpEAEAAGGAIF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   88 DGFPRTLGQAEALDKICE-----VDLVISLNIPFETLKDRLSRRWihPPSGRvynldfnpphvhgiddvtgeplvqqEDD 162
Cdd:PRK14532  84 DGFPRTVAQAEALDKMLAsrgqkIDVVIRLKVDDEALIERIVKRF--EEQGR-------------------------PDD 136

                        170       180       190
                 ....*....|....*....|....*....|....
gi 53832003  163 KPEAVAARLRQYKDVAKPVIELYKSRGVLHQFSG 196
Cdd:PRK14532 137 NPEVFVTRLDAYNAQTAPLLPYYAGQGKLTEVDG 170
PLN02200 PLN02200
adenylate kinase family protein
 10-211 3.52e-28

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 106.52  E-value: 3.52e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   10 ILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTEVGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQHWLLDG 89
Cdd:PLN02200  48 VLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSDNNKFLIDG 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   90 FPRTLGQAEALDKI--CEVDLVISLNIPFETLKDRLSRRwihpPSGRVynldfnpphvhgiddvtgeplvqqeDDKPEAV 167
Cdd:PLN02200 128 FPRTEENRIAFERIigAEPNVVLFFDCPEEEMVKRVLNR----NQGRV-------------------------DDNIDTI 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 53832003  168 AARLRQYKDVAKPVIELYKSRGVLHQFSGTET-NKIWPYVYTLFS 211
Cdd:PLN02200 179 KKRLKVFNALNLPVIDYYSKKGKLYTINAVGTvDEIFEQVRPIFA 223
AAA_17 pfam13207
AAA domain;
11-126 7.33e-26

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 97.31  E-value: 7.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    11 LGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKASTevGEMAKQYIEKSLLVPDHVITRLMMSELENRRGQH-WLLDG 89
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERIAEEAGEGgVIVDG 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 53832003    90 FPRTLGQAEALD-------KICEVDLVISLNIPFETLKDRLSRR 126
Cdd:pfam13207  79 HPRIKTPAGYLPglpvevlRELKPDAIILLEADPEEILERRLKD 122
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 126-161 1.04e-15

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 68.26  E-value: 1.04e-15
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 53832003   126 RWIHPPSGRVYNLDFNPPHVHGIDDVTGEPLVQQED 161
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 10-54 3.08e-08

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 50.95  E-value: 3.08e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 53832003  10 ILGPPGSGKGTVCQRIAQNFGLQHLSSGhFLRENikastEVGEMA 54
Cdd:cd02020   4 IDGPAGSGKSTVAKLLAKKLGLPYLDTG-GIRTE-----EVGKLA 42
cyt_kin_arch TIGR02173
cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. ...
 9-42 2.55e-07

cytidylate kinase, putative; Proteins in this family are believed to be cytidylate kinase. Members of this family are found in the archaea and in spirochaetes, and differ considerably from the common bacterial form of cytidylate kinase described by TIGR00017.


Pssm-ID: 274012 [Multi-domain]  Cd Length: 171  Bit Score: 48.96  E-value: 2.55e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 53832003     9 VILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRE 42
Cdd:TIGR02173   4 TISGPPGSGKTTVAKILAEKLSLKLISAGDIFRE 37
PRK04182 PRK04182
cytidylate kinase; Provisional
 6-42 1.27e-06

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 47.11  E-value: 1.27e-06
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 53832003    6 LRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRE 42
Cdd:PRK04182   1 MIITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
AAA_18 pfam13238
AAA domain;
9-126 3.36e-06

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 45.11  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003     9 VILGPPGSGKGTVCQRIAQNFGLqHLSSGHFLRENIKASTEVGEMAKQYIEKsLLVPDHVITRLMMSeLENRRGQHWLLD 88
Cdd:pfam13238   2 LITGTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETRESKRLD-EDKLDRLLDLLEEN-AALEEGGNLIID 78

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 53832003    89 GFPRTLGQAEALDKicevdLVISLNIPFETLKDRLSRR 126
Cdd:pfam13238  79 GHLAELEPERAKDL-----VGIVLRASPEELLERLEKR 111
Cytidylate_kin pfam02224
Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5 ...
 10-41 6.08e-06

Cytidylate kinase; Cytidylate kinase EC:2.7.4.14 catalyzes the phosphorylation of cytidine 5'-monophosphate (dCMP) to cytidine 5'-diphosphate (dCDP) in the presence of ATP or GTP.


Pssm-ID: 280401 [Multi-domain]  Cd Length: 211  Bit Score: 45.37  E-value: 6.08e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 53832003    10 ILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLR 41
Cdd:pfam02224   3 IDGPSGSGKSTVARILARKLGYKYLDTGAMYR 34
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
12-56 1.25e-05

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 44.63  E-value: 1.25e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 53832003  12 GPPGSGKGTVCQRIAQNFGLQHLSSG--------HFLRENIKAS--TEVGEMAKQ 56
Cdd:COG0283   7 GPAGSGKSTVAKALAKRLGYHYLDTGamyravalAALRNGIDLDdeEALAALARN 61
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
7-103 1.62e-04

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 42.10  E-value: 1.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHF------LREnIKASTEVGEMAKQYIEKSLLVPDHVITRLmmseLENR 80
Cdd:COG5635 182 RLLILGEPGSGKTTLLRYLALELAERYLDAEDPipilieLRD-LAEEASLEDLLAEALEKRGGEPEDALERL----LRNG 256

                        90       100
                ....*....|....*....|....*.
gi 53832003  81 RGqHWLLDGF---PRTLGQAEALDKI 103
Cdd:COG5635 257 RL-LLLLDGLdevPDEADRDEVLNQL 281
cmk TIGR00017
cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the ...
 10-41 3.64e-04

cytidylate kinase; This family consists of cytidylate kinase, which catalyzes the phosphorylation of cytidine 5-monophosphate (dCMP) to cytidine 5 -diphosphate (dCDP) in the presence of ATP or GTP. UMP and dCMP can also act as acceptors. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 129128 [Multi-domain]  Cd Length: 217  Bit Score: 40.10  E-value: 3.64e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 53832003    10 ILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLR 41
Cdd:TIGR00017   7 IDGPSGAGKSTVAKAVAEKLGYAYLDSGAMYR 38
aroK PRK00131
shikimate kinase; Reviewed
 7-125 7.16e-04

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 39.02  E-value: 7.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003    7 RAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKAS-----TEVGEMA-----KQYIEKSLLVPDHVITR---LM 73
Cdd:PRK00131   6 NIVLIGFMGAGKSTIGRLLAKRLGYDFIDTDHLIEARAGKSipeifEEEGEAAfreleEEVLAELLARHNLVISTgggAV 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 53832003   74 MSElENRrgqhwlldgfprtlgqaEALDKICevdLVISLNIPFETLKDRLSR 125
Cdd:PRK00131  86 LRE-ENR-----------------ALLRERG---TVVYLDASFEELLRRLRR 116
PRK11860 PRK11860
bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;
10-41 7.53e-04

bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidylate kinase;


Pssm-ID: 237003 [Multi-domain]  Cd Length: 661  Bit Score: 40.03  E-value: 7.53e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 53832003   10 ILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLR 41
Cdd:PRK11860 447 IDGPTASGKGTVAARVAEALGYHYLDSGALYR 478
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
12-126 1.13e-03

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 38.36  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003  12 GPPGSGKGTVCQRIAQNFGLQHLSS----GHFLRENIKA---STEVGEMAKQyieksllvpdhVITRLMMSELenRRGQH 84
Cdd:COG0645   6 GLPGSGKSTLARALAERLGAVRLRSdvvrKRLFGAGLAPlerSPEATARTYA-----------RLLALARELL--AAGRS 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 53832003  85 WLLD-GFPRTL--GQAEALDKICEVDLV-ISLNIPFETLKDRLSRR 126
Cdd:COG0645  73 VILDaTFLRRAqrEAFRALAEEAGAPFVlIWLDAPEEVLRERLEAR 118
PRK12269 PRK12269
bifunctional cytidylate kinase/ribosomal protein S1; Provisional
 12-56 1.91e-03

bifunctional cytidylate kinase/ribosomal protein S1; Provisional


Pssm-ID: 105491 [Multi-domain]  Cd Length: 863  Bit Score: 38.92  E-value: 1.91e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 53832003   12 GPPGSGKGTVCQRIAQNFGLQHLSSGHFLRE-NIKASTEVGEMAKQ 56
Cdd:PRK12269  41 GPAGSGKSSVCRLLASRLGAQCLNTGSFYRAfTLAALRRVSELAVQ 86
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 9-122 2.62e-03

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 37.40  E-value: 2.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003   9 VILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKaSTEVGEMAKQ--YIEkslLVPDhVITRLMMSELENrrGQHWL 86
Cdd:COG4088   8 ILTGPPGSGKTTFAKALAQRLYAEGIAVALLHSDDFR-RFLVNESFPKetYEE---VVED-VRTTTADNALDN--GYSVI 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 53832003  87 LDG---FPRTLGQAEALDKiCEVDL-VISLNIPFETLKDR 122
Cdd:COG4088  81 VDGtfyYRSWQRDFRNLAK-HKAPIhIIYLKAPLETALRR 119
PRK09518 PRK09518
bifunctional cytidylate kinase/GTPase Der; Reviewed
 6-41 2.84e-03

bifunctional cytidylate kinase/GTPase Der; Reviewed


Pssm-ID: 236546 [Multi-domain]  Cd Length: 712  Bit Score: 38.24  E-value: 2.84e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 53832003    6 LRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLR 41
Cdd:PRK09518   2 IIVAIDGPAGVGKSSVSRALAQYLGYAYLDTGAMYR 37
CmkB COG1102
Cytidylate kinase [Nucleotide transport and metabolism];
12-94 6.51e-03

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440719 [Multi-domain]  Cd Length: 188  Bit Score: 36.34  E-value: 6.51e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53832003  12 GPPGSGKGTVCQRIAQNFGLQHLsSGHFLREnikASTEVG---EMAKQYIEK--SLLVPDHVITRLMMSELENR------ 80
Cdd:COG1102   7 REPGSGGTTIAKRLAEKLGLPLY-DGEILRE---AAKERGlseEEFEKLDEKapSLLYRDTAEEDEIDRALDKVirelar 82

                        90       100
                ....*....|....*....|..
gi 53832003  81 --------RGQHWLLDGFPRTL 94
Cdd:COG1102  83 kgncvivgRLADWILRDRPNVL 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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