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Conserved domains on  [gi|55749459|ref|NP_001006938|]
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transcription elongation factor A protein-like 4 isoform 1 [Homo sapiens]

Protein Classification

BEX domain-containing protein( domain architecture ID 10517751)

BEX domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 88-193 3.10e-25

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


:

Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 94.63  E-value: 3.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459    88 SEREGKPEIEGKPESEGEPgsetraagkRPAEDDVPRKAKRKTNKG-LAHYLKEYKEAIHDMNFSNEDMIREFDNMAKVQ 166
Cdd:pfam04538   6 QENEGKPEEQGKVENEEEP---------EDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFG 76

                          90       100
                  ....*....|....*....|....*..
gi 55749459   167 DEKRKSKQKLGAFLWMQRNLQDPFYPR 193
Cdd:pfam04538  77 EEMRELRQKLREQQWRQRPHRDHHYPF 103
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 7-154 1.24e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 48.45  E-value: 1.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459      7 ENEGMASNQGKMENEEQPQDERKPEVTCTLEDKKLENEGKTENKGK---TGDEEMLKDKGKPESEGEAKEGKSEREGESE 83
Cdd:TIGR00927  692 EQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEgeeVEDEGEGEAEGKHEVETEGDRKETEHEGETE 771

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55749459     84 MEG-GSEREGKPEIEGKPESEGEPGSETRAAGKRPAEDDVPRKAKRKTNKGLAHYLKEYKEAIHDMNFSNED 154
Cdd:TIGR00927  772 AEGkEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQG 843
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 88-193 3.10e-25

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 94.63  E-value: 3.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459    88 SEREGKPEIEGKPESEGEPgsetraagkRPAEDDVPRKAKRKTNKG-LAHYLKEYKEAIHDMNFSNEDMIREFDNMAKVQ 166
Cdd:pfam04538   6 QENEGKPEEQGKVENEEEP---------EDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFG 76

                          90       100
                  ....*....|....*....|....*..
gi 55749459   167 DEKRKSKQKLGAFLWMQRNLQDPFYPR 193
Cdd:pfam04538  77 EEMRELRQKLREQQWRQRPHRDHHYPF 103
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 7-154 1.24e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 48.45  E-value: 1.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459      7 ENEGMASNQGKMENEEQPQDERKPEVTCTLEDKKLENEGKTENKGK---TGDEEMLKDKGKPESEGEAKEGKSEREGESE 83
Cdd:TIGR00927  692 EQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEgeeVEDEGEGEAEGKHEVETEGDRKETEHEGETE 771

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55749459     84 MEG-GSEREGKPEIEGKPESEGEPGSETRAAGKRPAEDDVPRKAKRKTNKGLAHYLKEYKEAIHDMNFSNED 154
Cdd:TIGR00927  772 AEGkEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQG 843
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
 88-193 3.10e-25

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 94.63  E-value: 3.10e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459    88 SEREGKPEIEGKPESEGEPgsetraagkRPAEDDVPRKAKRKTNKG-LAHYLKEYKEAIHDMNFSNEDMIREFDNMAKVQ 166
Cdd:pfam04538   6 QENEGKPEEQGKVENEEEP---------EDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFG 76

                          90       100
                  ....*....|....*....|....*..
gi 55749459   167 DEKRKSKQKLGAFLWMQRNLQDPFYPR 193
Cdd:pfam04538  77 EEMRELRQKLREQQWRQRPHRDHHYPF 103
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 7-154 1.24e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 48.45  E-value: 1.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459      7 ENEGMASNQGKMENEEQPQDERKPEVTCTLEDKKLENEGKTENKGK---TGDEEMLKDKGKPESEGEAKEGKSEREGESE 83
Cdd:TIGR00927  692 EQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEgeeVEDEGEGEAEGKHEVETEGDRKETEHEGETE 771

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55749459     84 MEG-GSEREGKPEIEGKPESEGEPGSETRAAGKRPAEDDVPRKAKRKTNKGLAHYLKEYKEAIHDMNFSNED 154
Cdd:TIGR00927  772 AEGkEDEDEGEIQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQG 843
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 36-130 4.51e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 46.91  E-value: 4.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459     36 LEDKKLENEGKTENKGKTGDEEMLKDKGKPESEGEAKEGKSEREGESEMEGGSEREGKPEIEGKPESEGEPGSETRAAGK 115
Cdd:TIGR00927  627 LGDLSKGDVAEAEHTGERTGEEGERPTEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADH 706

                           90
                   ....*....|....*
gi 55749459    116 RPAEDDVPRKAKRKT 130
Cdd:TIGR00927  707 KGETEAEEVEHEGET 721
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 6-125 7.41e-06

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 46.14  E-value: 7.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459      6 SENEGMASNQGKMENEEQPQDERKPEVTCTLEDKKLENEGKTENKGKTGDEEMLKDKGKPESEGEAKEGKSEREGESEME 85
Cdd:TIGR00927  673 TETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGEIETGEEGEEVEDEGEGEAEGK 752

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 55749459     86 GGSEREG---KPEIEGKPESEGEPGSEtraAGKRPAEDDVPRK 125
Cdd:TIGR00927  753 HEVETEGdrkETEHEGETEAEGKEDED---EGEIQAGEDGEMK 792
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 8-147 1.48e-05

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 45.37  E-value: 1.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459      8 NEGMASNQGKMENEEQPQDERKPEVtctledkklENEGKTENKgKTGDEEMlKDKGKPESEGEAKEGKSEREGESEmEGG 87
Cdd:TIGR00927  647 EEGERPTEAEGENGEESGGEAEQEG---------ETETKGENE-SEGEIPA-ERKGEQEGEGEIEAKEADHKGETE-AEE 714

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55749459     88 SEREGKPEIEG-KPESEGEPGSETRAAGKRP-----AEDDVPRKAKRKTNKGLAHYLKEYKEAIHD 147
Cdd:TIGR00927  715 VEHEGETEAEGtEDEGEIETGEEGEEVEDEGegeaeGKHEVETEGDRKETEHEGETEAEGKEDEDE 780
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 2-121 1.76e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 38.82  E-value: 1.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459      2 EKLYSENEGMASNQGKMENEEQPQD-ERKPEVTCTLEDKKLENEGKTENKGKTGDEemlkdkgkpESEGEAKEGkSEREG 80
Cdd:TIGR00927  724 EGTEDEGEIETGEEGEEVEDEGEGEaEGKHEVETEGDRKETEHEGETEAEGKEDED---------EGEIQAGED-GEMKG 793

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 55749459     81 ESEMEGGSEREGKPEIEGKPESEGEPGSETRAAGKRPAEDD 121
Cdd:TIGR00927  794 DEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGE 834
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 7-109 7.37e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 36.90  E-value: 7.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459      7 ENEGMASNQGKME-NEEQPQDERKPEVTCTLEDKKLENEGKTENKGKTGDEEMLKDKGKPESEGEAKEGKSEREGESEME 85
Cdd:TIGR00927  780 EGEIQAGEDGEMKgDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQDEKGVDGGGGSD 859

                           90       100
                   ....*....|....*....|....*
gi 55749459     86 GG-SEREGKPEIEGKPESEGEPGSE 109
Cdd:TIGR00927  860 GGdSEEEEEEEEEEEEEEEEEEEEE 884
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 7-111 7.64e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 36.90  E-value: 7.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55749459      7 ENEGMASNQGKMENEEQPQDERKPEvtcTLEDKKLENEGKTENKGKTGDEEmlkdKGKpESEGEAKEGKSEREGESEMEG 86
Cdd:TIGR00927  802 EHEGETEAGEKDEHEGQSETQADDT---EVKDETGEQELNAENQGEAKQDE----KGV-DGGGGSDGGDSEEEEEEEEEE 873

                           90       100
                   ....*....|....*....|....*....
gi 55749459     87 GSEREGKPEIEGKPESEGEPGS----ETR 111
Cdd:TIGR00927  874 EEEEEEEEEEEEEEEENEEPLSlewpETR 902
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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