NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|167466264|ref|NP_001006940|]
View 

leucine-rich repeat-containing protein 18 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-179 1.93e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 1.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLT 109
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264 110 SngLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPvSISKLPKLKKLNIKRNPF 179
Cdd:COG4886  196 D--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-179 1.93e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 1.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLT 109
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264 110 SngLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPvSISKLPKLKKLNIKRNPF 179
Cdd:COG4886  196 D--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-188 1.14e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 85.28  E-value: 1.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  49 LSDMDELDLSRNLIR-KIPDSISKFQNLRWLDLHSNYI-DKLPESIGQMTSLLYLNVSNNRLTSnGLPVELKQLKNIRAV 126
Cdd:PLN00113 139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQLVG-QIPRELGQMKSLKWI 217

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167466264 127 NLGLNHLD-SVPTTLGALKELHEVGL-HDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIF 188
Cdd:PLN00113 218 YLGYNNLSgEIPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF 281
LRR_8 pfam13855
Leucine rich repeat;
54-108 6.90e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 6.90e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 167466264   54 ELDLSRNLIRKI-PDSISKFQNLRWLDLHSNYIDKL-PESIGQMTSLLYLNVSNNRL 108
Cdd:pfam13855   5 SLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-198 1.92e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  55 LDLSRNLIRKIpDSISKFQNLRWLDLHSNYIDKL----------------------------PESI-GQMTSLLYLNVSN 105
Cdd:cd21340   51 LYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfdPRSLaALSNSLRVLNISG 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264 106 NRLTSnglPVELKQLKNIRAVNLGLNHLDSvpttlgaLKELHEVglhdnllnnipvsISKLPKLKKLNIKRNPF---PKP 182
Cdd:cd21340  130 NNIDS---LEPLAPLRNLEQLDASNNQISD-------LEELLDL-------------LSSWPSLRELDLTGNPVckkPKY 186

                        170
                 ....*....|....*.
gi 167466264 183 GESeiFIDSIRRLENL 198
Cdd:cd21340  187 RDK--IILASKSLEVL 200
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-179 1.93e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 1.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLT 109
Cdd:COG4886  116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264 110 SngLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPvSISKLPKLKKLNIKRNPF 179
Cdd:COG4886  196 D--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-179 6.56e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 6.56e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLT 109
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264 110 SngLPVELKQLKNIRAVNLGLNHLDSVPtTLGALKELHEVGLHDNLLNNIPvSISKLPKLKKLNIKRNPF 179
Cdd:COG4886  219 D--LPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-179 2.07e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.47  E-value: 2.07e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  46 ILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSngLPVELKQLKNIRA 125
Cdd:COG4886  109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTD--LPEELGNLTNLKE 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 167466264 126 VNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPF 179
Cdd:COG4886  187 LDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-177 6.03e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 6.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  46 ILRLSDMDELDLSRNlirkipDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSngLPVELKQLKNIRA 125
Cdd:COG4886   92 LGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKS 163

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 167466264 126 VNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
Cdd:COG4886  164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN 215
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-188 1.14e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 85.28  E-value: 1.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  49 LSDMDELDLSRNLIR-KIPDSISKFQNLRWLDLHSNYI-DKLPESIGQMTSLLYLNVSNNRLTSnGLPVELKQLKNIRAV 126
Cdd:PLN00113 139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQLVG-QIPRELGQMKSLKWI 217

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 167466264 127 NLGLNHLD-SVPTTLGALKELHEVGL-HDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIF 188
Cdd:PLN00113 218 YLGYNNLSgEIPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF 281
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-192 1.27e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPEsIGQMTSLLYLNVSNNRLT 109
Cdd:COG4886  185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLT 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264 110 SngLPvELKQLKNIRAVNLGLNHLDSVP-TTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIF 188
Cdd:COG4886  264 D--LP-PLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340


                 ....
gi 167466264 189 IDSI 192
Cdd:COG4886  341 ALSL 344
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
19-224 9.41e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 9.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  19 RNCIKitfDGKKRLDLSKMGITTFPKCILRlsDMDELDLSRNLIRKIPDSISKfqNLRWLDLHSNYIDKLPE----SIGQ 94
Cdd:PRK15370 173 RDCLK---NNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPAtlpdTIQE 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  95 M---------------TSLLYLNVSNNRLTS--NGLPVELKQL----KNIRAVNL----GLNHLDSVPTTLGALKELHEV 149
Cdd:PRK15370 246 MelsinritelperlpSALQSLDLFHNKISClpENLPEELRYLsvydNSIRTLPAhlpsGITHLNVQSNSLTALPETLPP 325

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264 150 GLH-----DNLLNNIPVSISklPKLKKLNIKRNP---FPK---PGESEIFIDsirrlENLYVVEEKDLCAAcLRKCQNAR 218
Cdd:PRK15370 326 GLKtleagENALTSLPASLP--PELQVLDVSKNQitvLPEtlpPTITTLDVS-----RNALTNLPENLPAA-LQIMQASR 397


                 ....*.
gi 167466264 219 DNLNRI 224
Cdd:PRK15370 398 NNLVRL 403
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-139 5.75e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 5.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  30 KRLDLSKMGIT-TFPKCILRLSDMDELDLSRNLIR-KIPDSISKFQNLRWLDL-HSNYIDKLPESIGQMTSLLYLNVSNN 106
Cdd:PLN00113 478 ENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLsHNQLSGQIPASFSEMPVLSQLDLSQN 557

                         90       100       110
                 ....*....|....*....|....*....|....
gi 167466264 107 RLtSNGLPVELKQLKNIRAVNLGLNHLD-SVPTT 139
Cdd:PLN00113 558 QL-SGEIPKNLGNVESLVQVNISHNHLHgSLPST 590
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-177 7.62e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 7.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRltsn 111
Cdd:COG4886   32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---- 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167466264 112 glpvELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
Cdd:COG4886  108 ----ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN 169
PLN03150 PLN03150
hypothetical protein; Provisional
 52-167 1.65e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  52 MDELDLSRNLIR-KIPDSISKFQNLRWLDLHSNYID-KLPESIGQMTSLLYLNVSNNRLtsNGlpvelkqlkniravnlg 129
Cdd:PLN03150 420 IDGLGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSF--NG----------------- 480

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 167466264 130 lnhldSVPTTLGALKELHEVGLHDNLLN-NIPVSISKLP 167
Cdd:PLN03150 481 -----SIPESLGQLTSLRILNLNGNSLSgRVPAALGGRL 514
PLN03150 PLN03150
hypothetical protein; Provisional
 26-117 1.74e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 1.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  26 FDGKKR------LDLSKMGITTF-PKCILRLSDMDELDLSRNLIR-KIPDSISKFQNLRWLDLHSNYID-KLPESIGQMT 96
Cdd:PLN03150 411 FDSTKGkwfidgLGLDNQGLRGFiPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLT 490

                         90       100
                 ....*....|....*....|.
gi 167466264  97 SLLYLNVSNNRLtSNGLPVEL 117
Cdd:PLN03150 491 SLRILNLNGNSL-SGRVPAAL 510
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-198 9.54e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 9.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  43 PKCILRLSDMDELDLSRN-LIRKIPDSISKFQNLRWLDLHSN-YIDKLPESIGQMTSLLYLNVSNNRLtSNGLPVELKQL 120
Cdd:PLN00113 277 PPSIFSLQKLISLDLSDNsLSGEIPELVIQLQNLEILHLFSNnFTGKIPVALTSLPRLQVLQLWSNKF-SGEIPKNLGKH 355

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264 121 KNIRAVNLGLNHL-------------------------DSVPTTLGALKELHEVGLHDN--------------------- 154
Cdd:PLN00113 356 NNLTVLDLSTNNLtgeipeglcssgnlfklilfsnsleGEIPKSLGACRSLRRVRLQDNsfsgelpseftklplvyfldi 435

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 167466264 155 ----LLNNIPVSISKLPKLKKLNIKRNPFpkPGESEIFIDSiRRLENL 198
Cdd:PLN00113 436 snnnLQGRINSRKWDMPSLQMLSLARNKF--FGGLPDSFGS-KRLENL 480
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-179 3.91e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 3.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  50 SDMDELDLS-RNLIRKIPDSISKFQNLRWLDLHSNYID-KLPESIGQMT-SLLYLNVSNNRLTSnglPVELKQLKNIRAV 126
Cdd:PLN00113  69 SRVVSIDLSgKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTG---SIPRGSIPNLETL 145

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 167466264 127 NLGLNHLD-SVPTTLGALKELHEVGLHDN-LLNNIPVSISKLPKLKKLNIKRNPF 179
Cdd:PLN00113 146 DLSNNMLSgEIPNDIGSFSSLKVLDLGGNvLVGKIPNSLTNLTSLEFLTLASNQL 200
LRR_8 pfam13855
Leucine rich repeat;
54-108 6.90e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 6.90e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 167466264   54 ELDLSRNLIRKI-PDSISKFQNLRWLDLHSNYIDKL-PESIGQMTSLLYLNVSNNRL 108
Cdd:pfam13855   5 SLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-177 2.60e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 2.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  55 LDLSRN-LIRKIPDSiSKFQNLRWLDLHSNYIDK-LPESIGQMTSLLYLNVSNNRLTSNgLPVELKQLKNIraVNLGLNH 132
Cdd:PLN00113 457 LSLARNkFFGGLPDS-FGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGE-IPDELSSCKKL--VSLDLSH 532

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 167466264 133 ldsvpttlgalkelhevglhDNLLNNIPVSISKLPKLKKLNIKRN 177
Cdd:PLN00113 533 --------------------NQLSGQIPASFSEMPVLSQLDLSQN 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-198 1.92e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  55 LDLSRNLIRKIpDSISKFQNLRWLDLHSNYIDKL----------------------------PESI-GQMTSLLYLNVSN 105
Cdd:cd21340   51 LYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfdPRSLaALSNSLRVLNISG 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264 106 NRLTSnglPVELKQLKNIRAVNLGLNHLDSvpttlgaLKELHEVglhdnllnnipvsISKLPKLKKLNIKRNPF---PKP 182
Cdd:cd21340  130 NNIDS---LEPLAPLRNLEQLDASNNQISD-------LEELLDL-------------LSSWPSLRELDLTGNPVckkPKY 186

                        170
                 ....*....|....*.
gi 167466264 183 GESeiFIDSIRRLENL 198
Cdd:cd21340  187 RDK--IILASKSLEVL 200
LRR_8 pfam13855
Leucine rich repeat;
73-133 2.35e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.35e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167466264   73 QNLRWLDLHSNYIDKL-PESIGQMTSLLYLNVSNNRLTSNGlPVELKQLKNIRAVNLGLNHL 133
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
19-206 2.83e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 2.83e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  19 RNCIKitfDGKKRLDLSKMGITTFPKCI------LRLSD------------MDELDLSRNLIRKIPDSISKFQNLRWLDL 80
Cdd:PRK15387 196 RACLN---NGNAVLNVGESGLTTLPDCLpahittLVIPDnnltslpalppeLRTLEVSGNQLTSLPVLPPGLLELSIFSN 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  81 HSNYIDKLPESI-------GQMTSLLYL-------NVSNNRLTSngLPVELKQLKNIRAVNlglNHLDSVPTTLGALKEL 146
Cdd:PRK15387 273 PLTHLPALPSGLcklwifgNQLTSLPVLppglqelSVSDNQLAS--LPALPSELCKLWAYN---NQLTSLPTLPSGLQEL 347

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 167466264 147 hevGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPK-PGESEIFIDSIRRLENLYVV--EEKDL 206
Cdd:PRK15387 348 ---SVSDNQLASLPTLPSELYKLWAYNNRLTSLPAlPSGLKELIVSGNRLTSLPVLpsELKEL 407
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-206 4.75e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 4.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264  30 KRLDLSKMGITTFPKcILRLSDMDELDLSRNLIRKIPDSiSKFQNLRWLDLHSNYI-----DKLPESIGQMTSLLYLNVS 104
Cdd:COG4886  231 ETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLtdlklKELELLLGLNSLLLLLLLL 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167466264 105 NNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGE 184
Cdd:COG4886  309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                        170       180
                 ....*....|....*....|..
gi 167466264 185 SEIFIDSIRRLENLYVVEEKDL 206
Cdd:COG4886  389 LLLLLLTTTAGVLLLTLALLDA 410
LRR_8 pfam13855
Leucine rich repeat;
30-85 3.40e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 3.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 167466264   30 KRLDLSKMGITTF-PKCILRLSDMDELDLSRNLIRKI-PDSISKFQNLRWLDLHSNYI 85
Cdd:pfam13855   4 RSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH