NCBI Conserved Domain Search

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

448-708

2.21e-63

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 212.32 E-value: 2.21e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 448 WTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMST-HRHGLGVAVLEGPMYAVGG---- 522
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGftga 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 523 HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 602
Cdd:COG3055  83 NPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 603 GVTT-WNGLLYAIGGHDAPASNLTsrlsdcverydpktdmWTAVASMSISRDAVGVCLLGDKLYAVGGYDGqaYLNTVEA 681
Cdd:COG3055 163 AAAVlPDGKILVIGGRNGSGFSNT----------------WTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEA 224

                       250       260
                ....*....|....*....|....*..
gi 55770880 682 YDPQTNEWTQVAPLCLGRAGACVVTVK 708
Cdd:COG3055 225 YDPATNTWTALGELPTPRHGHAAVLTD 251

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

276-375

5.68e-40

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 141.91 E-value: 5.68e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880   276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD 355
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|
gi 55770880   356 LSKLLAYIRLPLLAPQFLAD 375
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLN 100

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

276-375

1.74e-34

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 126.69 E-value: 1.74e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880    276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD 355
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 55770880    356 LSKLLAYIRLPLLAPQFLAD 375
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100

Name

Accession

Description

Interval

E-value

PHA03098

kelch-like protein; Provisional

174-696

6.63e-96

kelch-like protein; Provisional

Pssm-ID: 222983 [Multi-domain] Cd Length: 534 Bit Score: 306.69 E-value: 6.63e-96

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  174 CD--VILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREarqEEIKMEGVEpNSLWSLIQYAYTGRLELKEDNIECLLSTA 251
Cdd:PHA03098  10 CDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNIDY-DSFNEVIKYIYTGKINITSNNVKDILSIA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  252 CLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNI 331
Cdd:PHA03098  86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  332 PNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADME--------NNVLFRDDieCQKLIMEAMKYhllpe 403
Cdd:PHA03098 166 SSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIKKLKrwklrikkKKIVFNKR--CIKIIYSKKYN----- 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  404 rrpmlqSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNgrRLQFGVAVLDDKLYVVGGRDG-LKTL 482
Cdd:PHA03098 239 ------LNKILPRSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNNVIYFIGGMNKnNLSV 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  483 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSG 562
Cdd:PHA03098 311 NSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPPLIFPRYNPCVVNVNN 390

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  563 KLYAVGG-RDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGhdapASNLTSRLS-DCVERYDPKTD 640
Cdd:PHA03098 391 LIYVIGGiSKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGG----ISYIDNIKVyNIVESYNPVTN 466

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 55770880  641 MWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLC 696
Cdd:PHA03098 467 KWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFP 522

BTB_POZ_KLHL5

cd18337

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

151-280

8.96e-85

Pssm-ID: 349646 [Multi-domain] Cd Length: 130 Bit Score: 263.07 E-value: 8.96e-85

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 151 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQ 230
Cdd:cd18337   1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQ 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 55770880 231 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 280
Cdd:cd18337  81 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 130

BTB_POZ_KLHL4

cd18336

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-280

8.30e-78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349645 [Multi-domain] Cd Length: 126 Bit Score: 244.95 E-value: 8.30e-78

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18336   1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYT 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 280
Cdd:cd18336  81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGIR 126

BACK_KLHL5

cd18511

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...

270-375

4.85e-77

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.

Pssm-ID: 350586 [Multi-domain] Cd Length: 106 Bit Score: 241.89 E-value: 4.85e-77

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDL 349
Cdd:cd18511   1 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDV 80

                        90       100
                ....*....|....*....|....*.
gi 55770880 350 EQRRKDLSKLLAYIRLPLLAPQFLAD 375
Cdd:cd18511  81 EQRRKDLSKLLAYIRLPLLAPQFLAD 106

BTB_POZ_KLHL1-like

cd18234

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-277

3.95e-76

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349543 [Multi-domain] Cd Length: 105 Bit Score: 239.58 E-value: 3.95e-76

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTAC 252
Cdd:cd18234   1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                        90       100
                ....*....|....*....|....*
gi 55770880 253 LLQLSQVVEACCKFLMKQLHPSNCL 277
Cdd:cd18234  81 LLQLSEVVEACCGFLMKQLHPSNCL 105

BACK_KLHL1_like

cd18444

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...

270-375

1.88e-74

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.

Pssm-ID: 350519 [Multi-domain] Cd Length: 106 Bit Score: 235.30 E-value: 1.88e-74

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDL 349
Cdd:cd18444   1 QLHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDL 80

                        90       100
                ....*....|....*....|....*.
gi 55770880 350 EQRRKDLSKLLAYIRLPLLAPQFLAD 375
Cdd:cd18444  81 PERKKHLAKLLALIRLPLLTPQFLAD 106

BTB_POZ_KLHL1

cd18335

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-280

3.02e-66

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349644 [Multi-domain] Cd Length: 126 Bit Score: 214.52 E-value: 3.02e-66

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18335   1 HHAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYT 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIR 280
Cdd:cd18335  81 GCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGIR 126

BACK_KLHL4

cd18510

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...

270-375

1.89e-63

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350585 [Multi-domain] Cd Length: 106 Bit Score: 206.31 E-value: 1.89e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDL 349
Cdd:cd18510   1 QLHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDL 80

                        90       100
                ....*....|....*....|....*.
gi 55770880 350 EQRRKDLSKLLAYIRLPLLAPQFLAD 375
Cdd:cd18510  81 QNRQKDLGMLLSYIRLPLLPPQLLAD 106

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

448-708

2.21e-63

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 212.32 E-value: 2.21e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 448 WTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMST-HRHGLGVAVLEGPMYAVGG---- 522
Cdd:COG3055   3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGftga 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 523 HDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGV 602
Cdd:COG3055  83 NPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 603 GVTT-WNGLLYAIGGHDAPASNLTsrlsdcverydpktdmWTAVASMSISRDAVGVCLLGDKLYAVGGYDGqaYLNTVEA 681
Cdd:COG3055 163 AAAVlPDGKILVIGGRNGSGFSNT----------------WTTLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEA 224

                       250       260
                ....*....|....*....|....*..
gi 55770880 682 YDPQTNEWTQVAPLCLGRAGACVVTVK 708
Cdd:COG3055 225 YDPATNTWTALGELPTPRHGHAAVLTD 251

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

415-669

8.25e-63

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 210.78 E-value: 8.25e-63

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 415 PRKSTV-----GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNG-RRLQFGVAVLDDKLYVVGGRDG----LKTLNT 484
Cdd:COG3055  12 PRSEAAaalldGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGpPRHHAAAVAQDGKLYVFGGFTGanpsSTPLND 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 485 VECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL-SGK 563
Cdd:COG3055  92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGK 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 564 LYAVGGRDGSSclksvecfdpHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNltsrlsdcVERYDPKTDMWT 643
Cdd:COG3055 172 ILVIGGRNGSG----------FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE--------VEAYDPATNTWT 233

                       250       260
                ....*....|....*....|....*.
gi 55770880 644 AVASMSISRDAVGVCLLGDKLYAVGG 669
Cdd:COG3055 234 ALGELPTPRHGHAAVLTDGKVYVIGG 259

BACK_KLHL1

cd18509

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...

271-375

5.11e-59

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.

Pssm-ID: 350584 [Multi-domain] Cd Length: 106 Bit Score: 194.47 E-value: 5.11e-59

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18509   2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                        90       100
                ....*....|....*....|....*
gi 55770880 351 QRRKDLSKLLAYIRLPLLAPQFLAD 375
Cdd:cd18509  82 RRCSDLSMLLAYIRLPLLPPQLLAD 106

BACK_KLHL2_like

cd18445

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...

271-383

8.72e-51

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.

Pssm-ID: 350520 [Multi-domain] Cd Length: 114 Bit Score: 172.42 E-value: 8.72e-51

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18445   1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 55770880 351 QRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFR 383
Cdd:cd18445  81 NRKEHLAELLEHVRLPLLSPEYLVQrVEEEELIK 114

BACK_KLHL12

cd18452

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...

271-405

8.11e-48

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.

Pssm-ID: 350527 [Multi-domain] Cd Length: 136 Bit Score: 164.88 E-value: 8.11e-48

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18452   1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 55770880 351 QRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERR 405
Cdd:cd18452  81 EREDYLPELLQYVRLPLLSPRYITDvVDAEPLIRCSLECRDLVDEAKKFHLRPELR 136

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

421-636

5.11e-44

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 159.55 E-value: 5.11e-44

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 421 GTLFAVGGMDSTKGA----TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWS 496
Cdd:COG3055  71 GKLYVFGGFTGANPSstplNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWT 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 497 VMPPMSTHRHGLGVAVL-EGPMYAVGGHDGWSYLNTverwdpqarqWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSc 575
Cdd:COG3055 151 QLAPLPTPRDHLAAAVLpDGKILVIGGRNGSGFSNT----------WTTLAPLPTARAGHAAAVLGGKILVFGGESGFS- 219

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55770880 576 lKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSdcVERYD 636
Cdd:COG3055 220 -DEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPLVTS--AEVYD 277

BTB_POZ_KLHL2-like

cd18235

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-273

5.92e-43

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349544 [Multi-domain] Cd Length: 121 Bit Score: 151.04 E-value: 5.92e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18235   4 HTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTA 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 273
Cdd:cd18235  84 EIQVTEENVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121

BTB_POZ_KLHL8

cd18238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

161-278

6.38e-43

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349547 [Multi-domain] Cd Length: 120 Bit Score: 150.90 E-value: 6.38e-43

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 161 FKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 240
Cdd:cd18238   3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLT 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 55770880 241 EDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLG 278
Cdd:cd18238  83 VDNVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120

BTB_POZ_KLHL18

cd18247

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

159-270

5.16e-41

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349556 [Multi-domain] Cd Length: 116 Bit Score: 145.50 E-value: 5.16e-41

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 159 QTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLE 238
Cdd:cd18247   5 SGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIA 84

                        90       100       110
                ....*....|....*....|....*....|..
gi 55770880 239 LKEDNIECLLSTACLLQLSQVVEACCKFLMKQ 270
Cdd:cd18247  85 IDTSNVQSLLVGASFLQLQSVKDACCEFLKER 116

BTB_POZ_KLHL20_KLEIP

cd18249

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-278

2.65e-40

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349558 [Multi-domain] Cd Length: 128 Bit Score: 144.13 E-value: 2.65e-40

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18249   6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTS 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLG 278
Cdd:cd18249  86 QITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128

BACK

pfam07707

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...

276-375

5.68e-40

Pssm-ID: 462237 [Multi-domain] Cd Length: 103 Bit Score: 141.91 E-value: 5.68e-40

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880   276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD 355
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|
gi 55770880   356 LSKLLAYIRLPLLAPQFLAD 375
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLN 100

NanM

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

541-707

1.35e-39

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];

Pssm-ID: 442289 [Multi-domain] Cd Length: 277 Bit Score: 147.22 E-value: 1.35e-39

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 541 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMS-KRRGGVGVTTWNGLLYAIGGHDA 619
Cdd:COG3055   2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 620 PASNLTSrLSDcVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGR 699
Cdd:COG3055  82 ANPSSTP-LND-VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPR 159


                ....*...
gi 55770880 700 AGACVVTV 707
Cdd:COG3055 160 DHLAAAVL 167

BACK_KLHL2_Mayven

cd18512

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...

271-399

2.85e-38

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.

Pssm-ID: 350587 [Multi-domain] Cd Length: 130 Bit Score: 138.24 E-value: 2.85e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18512   1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 55770880 351 QRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYH 399
Cdd:cd18512  81 VRQEHMAHLMEHVRLPLLSREYLVQrVEEETLVKNSSACKDYLIEAMKYH 130

BTB_POZ_KLHL12_C3IP1_DKIR

cd18242

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-276

5.54e-38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349551 [Multi-domain] Cd Length: 124 Bit Score: 137.19 E-value: 5.54e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18242   4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTE 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNC 276
Cdd:cd18242  84 TVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124

BTB_POZ_KLHL27_IPP

cd18256

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-278

8.97e-38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349565 [Multi-domain] Cd Length: 125 Bit Score: 136.77 E-value: 8.97e-38

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMeNYLRHKQ-LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAY 233
Cdd:cd18256   2 KHASLILAQL-NKLRGQHeFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 55770880 234 TGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLG 278
Cdd:cd18256  81 TGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125

BACK_KLHL18

cd18457

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...

271-375

2.48e-37

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.

Pssm-ID: 350532 [Multi-domain] Cd Length: 107 Bit Score: 134.74 E-value: 2.48e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18457   1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                        90       100
                ....*....|....*....|....*
gi 55770880 351 QRRKDLSKLLAYIRLPLLAPQFLAD 375
Cdd:cd18457  81 NREEYLPELLSKVRLPLLRPQFLTD 105

BTB_POZ_KLHL7

cd18237

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

153-278

3.00e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349546 [Multi-domain] Cd Length: 126 Bit Score: 135.31 E-value: 3.00e-37

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 153 ALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYA 232
Cdd:cd18237   1 EAKLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFA 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 55770880 233 YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLG 278
Cdd:cd18237  81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126

BACK_KLHL3

cd18513

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...

271-399

1.07e-35

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.

Pssm-ID: 350588 [Multi-domain] Cd Length: 130 Bit Score: 131.34 E-value: 1.07e-35

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18513   1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 55770880 351 QRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYH 399
Cdd:cd18513  81 ARLEHMAKLMEHVRLPLLPRDYLVQtVEEEALIKNNNTCKDFLIEAMKYH 130

BTB_POZ_KLHL28_BTBD5

cd18257

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-273

1.65e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349566 [Multi-domain] Cd Length: 118 Bit Score: 127.27 E-value: 1.65e-34

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18257   1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTG 80

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 273
Cdd:cd18257  81 TVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118

BACK

smart00875

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...

276-375

1.74e-34

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.

Pssm-ID: 197943 [Multi-domain] Cd Length: 101 Bit Score: 126.69 E-value: 1.74e-34

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880    276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD 355
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 55770880    356 LSKLLAYIRLPLLAPQFLAD 375
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100

BTB_POZ_KLHL19_KEAP1

cd18248

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-271

1.38e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349557 [Multi-domain] Cd Length: 124 Bit Score: 124.80 E-value: 1.38e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMeNYLR-HKQLCDVILVAG----DRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLI 229
Cdd:cd18248   3 DHTKEAFQIM-NELRlSQQLCDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLI 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 55770880 230 QYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQL 271
Cdd:cd18248  82 EFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123

BACK_KLHL20

cd18459

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...

270-368

1.79e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.

Pssm-ID: 350534 [Multi-domain] Cd Length: 100 Bit Score: 123.69 E-value: 1.79e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDL 349
Cdd:cd18459   1 QLDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNI 80

                        90
                ....*....|....*....
gi 55770880 350 EQRRKDLSKLLAYIRLPLL 368
Cdd:cd18459  81 QERRPHLPQVLQHVRLPLL 99

BTB_POZ_KLHL26

cd18255

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

166-276

8.17e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349564 [Multi-domain] Cd Length: 121 Bit Score: 122.50 E-value: 8.17e-33

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 166 NYLRHK-QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNI 244
Cdd:cd18255  10 NALRAKgQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCI 89

                        90       100       110
                ....*....|....*....|....*....|..
gi 55770880 245 ECLLSTACLLQLSQVVEACCKFLMKQLHPSNC 276
Cdd:cd18255  90 QDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121

BTB_POZ_KLHL24_KRIP6

cd18253

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-276

1.18e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349562 [Multi-domain] Cd Length: 121 Bit Score: 122.25 E-value: 1.18e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18253   1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTG 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNC 276
Cdd:cd18253  81 KVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121

BTB_POZ_KLHL3

cd18339

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-273

1.53e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349648 [Multi-domain] Cd Length: 121 Bit Score: 121.75 E-value: 1.53e-32

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMeNYLRHKQ-LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18339   4 HMKKAFKVM-NELRSKQlLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYT 82

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 273
Cdd:cd18339  83 AEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121

BTB_POZ_KLHL38

cd18268

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

166-279

1.52e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349577 [Multi-domain] Cd Length: 129 Bit Score: 119.51 E-value: 1.52e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 166 NYLRHKQ-LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNI 244
Cdd:cd18268  15 NSLRQERiLTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILITRDNV 94

                        90       100       110
                ....*....|....*....|....*....|....*
gi 55770880 245 ECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18268  95 LPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129

BACK_KLHL8

cd18448

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...

270-366

1.56e-31

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.

Pssm-ID: 350523 [Multi-domain] Cd Length: 97 Bit Score: 118.18 E-value: 1.56e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDL 349
Cdd:cd18448   1 HLHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDP 80

                        90
                ....*....|....*..
gi 55770880 350 EQRRKDLSKLLAYIRLP 366
Cdd:cd18448  81 QHRKRHLDDLLSQVRLP 97

BACK_KLHL17

cd18456

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...

271-372

1.65e-31

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.

Pssm-ID: 350531 [Multi-domain] Cd Length: 102 Bit Score: 118.18 E-value: 1.65e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18456   1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                        90       100
                ....*....|....*....|..
gi 55770880 351 QRRKDLSKLLAYIRLPLLAPQF 372
Cdd:cd18456  81 GRRQHVPRLMKCVRLPLLSRDF 102

BTB_POZ_KLHL2_Mayven

cd18338

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-273

6.93e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349647 [Multi-domain] Cd Length: 121 Bit Score: 117.09 E-value: 6.93e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18338   4 HMKKAFKVMNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTA 83

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 273
Cdd:cd18338  84 EIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121

BTB_POZ_KLHL10

cd18240

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-276

7.13e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349549 [Multi-domain] Cd Length: 120 Bit Score: 117.04 E-value: 7.13e-31

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFkkmeNYLR-HKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18240   3 MACNVF----NELRlEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYT 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNC 276
Cdd:cd18240  79 RTVPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120

BTB

pfam00651

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...

164-271

1.28e-30

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

Pssm-ID: 395526 [Multi-domain] Cd Length: 107 Bit Score: 115.82 E-value: 1.28e-30

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880   164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLeLKEDN 243
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 55770880   244 IECLLSTACLLQLSQVVEACCKFLMKQL 271
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107

BTB_POZ_KLHL21

cd18250

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-276

1.30e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349559 [Multi-domain] Cd Length: 124 Bit Score: 116.41 E-value: 1.30e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18250   4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTG 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNC 276
Cdd:cd18250  84 RVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124

BTB_POZ_ZBTB_KLHL-like

cd18186

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-254

1.42e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349497 [Multi-domain] Cd Length: 82 Bit Score: 114.96 E-value: 1.42e-30

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTAC 252
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                ..
gi 55770880 253 LL 254
Cdd:cd18186  81 KL 82

BTB_POZ_NS1BP

cd18306

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-279

2.01e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349615 [Multi-domain] Cd Length: 124 Bit Score: 113.12 E-value: 2.01e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMeNYLR-HKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18306   1 HPESVLAKL-NALRkNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYT 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18306  80 SRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124

BTB_POZ_KLHL17_actinfilin

cd18246

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-273

5.14e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349555 [Multi-domain] Cd Length: 139 Bit Score: 112.43 E-value: 5.14e-29

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18246  22 HYHDAFVSMNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTA 101

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 273
Cdd:cd18246 102 EIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139

BTB

smart00225

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...

175-271

4.44e-28

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

Pssm-ID: 197585 [Multi-domain] Cd Length: 97 Bit Score: 108.16 E-value: 4.44e-28

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880    175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL 254
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 55770880    255 QLSQVVEACCKFLMKQL 271
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB_POZ_KLHL37_ENC1

cd18267

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

150-279

9.84e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349576 [Multi-domain] Cd Length: 147 Bit Score: 109.31 E-value: 9.84e-28

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 150 FFQALNHAEQTFKKMeNYLRHKQL-CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKM-EGVEPNSLWS 227
Cdd:cd18267  17 LFHKSSYADSVLTHL-NLLRQQRLfTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFhDSIHPEVLEL 95

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 55770880 228 LIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18267  96 LLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147

BTB_POZ_KLHL25

cd18254

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

154-278

1.07e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349563 [Multi-domain] Cd Length: 128 Bit Score: 108.18 E-value: 1.07e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 154 LNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKM-EGVEPNSLWSLIQYA 232
Cdd:cd18254   3 PSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFhDSLHPEVLELLLDFA 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 55770880 233 YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLG 278
Cdd:cd18254  83 YSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128

BTB_POZ_KLHL35

cd18265

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-278

3.00e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349574 [Multi-domain] Cd Length: 128 Bit Score: 107.17 E-value: 3.00e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18265   6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGG 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLG 278
Cdd:cd18265  86 GLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128

BTB_POZ_KLHL30

cd18259

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-278

3.36e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349568 [Multi-domain] Cd Length: 137 Bit Score: 107.22 E-value: 3.36e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18259  14 SHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYT 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLG 278
Cdd:cd18259  94 GKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137

BTB_POZ_KLHL36

cd18266

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-283

5.94e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349575 [Multi-domain] Cd Length: 135 Bit Score: 106.51 E-value: 5.94e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18266   7 DHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYS 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 283
Cdd:cd18266  87 SELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYLYLQELA 135

BACK_KLHL29_KBTBD9

cd18468

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...

272-373

6.05e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.

Pssm-ID: 350543 [Multi-domain] Cd Length: 102 Bit Score: 105.19 E-value: 6.05e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 272 HPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQ 351
Cdd:cd18468   1 TPSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKN 80

                        90       100
                ....*....|....*....|..
gi 55770880 352 RRKDLSKLLAYIRLPLLAPQFL 373
Cdd:cd18468  81 RKQHIAELLAVVRLPFIHPSYL 102

BTB_POZ_KLHL6

cd18236

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

164-278

8.43e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349545 [Multi-domain] Cd Length: 129 Bit Score: 105.70 E-value: 8.43e-27

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDN 243
Cdd:cd18236  15 LENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQN 94

                        90       100       110
                ....*....|....*....|....*....|....*
gi 55770880 244 IECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLG 278
Cdd:cd18236  95 VQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129

BTB_POZ_KBTBD6_7

cd18273

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-279

3.85e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349582 [Multi-domain] Cd Length: 142 Bit Score: 104.52 E-value: 3.85e-26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVIL-VAG-------DRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLW 226
Cdd:cd18273   8 AHARALLAQLKSFYDARLLTDVTIeVNGpgsgpgsGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMA 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 55770880 227 SLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18273  88 LIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGI 140

BTB_POZ_KLHL40-like

cd18269

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

168-279

7.32e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349578 [Multi-domain] Cd Length: 133 Bit Score: 103.25 E-value: 7.32e-26

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 168 LRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECL 247
Cdd:cd18269  22 LDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDI 101

                        90       100       110
                ....*....|....*....|....*....|..
gi 55770880 248 LSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18269 102 FALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133

BACK_KLHL19_KEAP1

cd18458

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...

270-360

1.85e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.

Pssm-ID: 350533 [Multi-domain] Cd Length: 91 Bit Score: 100.45 E-value: 1.85e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDL 349
Cdd:cd18458   1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                        90
                ....*....|.
gi 55770880 350 EQRRKDLSKLL 360
Cdd:cd18458  81 ENRRQYLEALL 91

BTB_POZ_KLHL40_KBTBD5

cd18340

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

164-279

2.22e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349649 [Multi-domain] Cd Length: 134 Bit Score: 101.84 E-value: 2.22e-25

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDN 243
Cdd:cd18340  18 LKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQN 97

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 55770880 244 IECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18340  98 VQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133

BACK_KBTBD3

cd18480

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

274-352

2.86e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350555 [Multi-domain] Cd Length: 82 Bit Score: 99.71 E-value: 2.86e-25

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55770880 274 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQR 352
Cdd:cd18480   4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82

BACK_KLHL28_BTBD5

cd18467

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...

271-369

1.33e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.

Pssm-ID: 350542 [Multi-domain] Cd Length: 99 Bit Score: 98.48 E-value: 1.33e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18467   1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                        90
                ....*....|....*....
gi 55770880 351 QRRKDLSKLLAYIRLPLLA 369
Cdd:cd18467  81 ERQKYLAQLLHCVRLPLLS 99

BACK_KEL_like

cd18508

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...

274-348

2.72e-24

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.

Pssm-ID: 350583 [Multi-domain] Cd Length: 77 Bit Score: 96.71 E-value: 2.72e-24

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55770880 274 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHD 348
Cdd:cd18508   3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77

BTB_POZ_KBTBD2_BKLHD1

cd18270

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-277

7.51e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349579 [Multi-domain] Cd Length: 133 Bit Score: 97.38 E-value: 7.51e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18270   9 YAVSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTG 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCL 277
Cdd:cd18270  89 NLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130

BTB_POZ_KLHL22

cd18251

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-268

9.62e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349560 [Multi-domain] Cd Length: 125 Bit Score: 96.81 E-value: 9.62e-24

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTAC 252
Cdd:cd18251  23 LFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAAC 102

                        90
                ....*....|....*.
gi 55770880 253 LLQLSQVVEACCKFLM 268
Cdd:cd18251 103 QLQIPEVIGFCCDFLM 118

BTB_POZ_KBTBD8

cd18274

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-279

1.41e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349583 [Multi-domain] Cd Length: 129 Bit Score: 96.60 E-value: 1.41e-23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVIL-VAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18274   5 HACSILQQLKAMYDEGQLTDIVVeVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYT 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18274  85 SRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129

BTB_POZ_KLHL9_13

cd18239

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

151-276

2.28e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349548 [Multi-domain] Cd Length: 128 Bit Score: 96.03 E-value: 2.28e-23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 151 FQALNHAEQTFKKMENYLRHKQLCDVILVAGD--RRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSL 228
Cdd:cd18239   1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNI 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 55770880 229 IQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNC 276
Cdd:cd18239  81 IDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128

BTB_POZ_KBTBD12

cd18276

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

172-279

2.61e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349585 [Multi-domain] Cd Length: 127 Bit Score: 95.64 E-value: 2.61e-23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 172 QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTA 251
Cdd:cd18276  20 ELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLTNSNVQGVATAA 99

                        90       100
                ....*....|....*....|....*...
gi 55770880 252 CLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18276 100 FFLQMEDIFSVCQKYMMDHMDASNCLGI 127

BTB_POZ_KBTBD3_BKLHD3

cd18271

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

150-279

5.04e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349580 [Multi-domain] Cd Length: 130 Bit Score: 94.90 E-value: 5.04e-23

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 150 FFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLI 229
Cdd:cd18271   1 SLVAECHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 55770880 230 QYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18271  81 DYAYTGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCLQL 130

PHA02790

Kelch-like protein; Provisional

223-642

2.41e-22

Kelch-like protein; Provisional

Pssm-ID: 165153 [Multi-domain] Cd Length: 480 Bit Score: 100.89 E-value: 2.41e-22

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  223 NSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEH 302
Cdd:PHA02790  72 HSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKH 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  303 FME----VIRNQEFVllpasEIAKLLASDDMNIPNEETILNALLTWVRhdleQRRKDLSKLLAY----IRLPLLAPQFLa 374
Cdd:PHA02790 152 FLEleddIIDNFDYL-----SMKLILESDELNVPDEDYVVDFVIKWYM----KRRNRLGNLLLLiknvIRSNYLSPRGI- 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  375 dmeNNVLFRddIECQKlIMEAMKYHLLPERRPMLQSPRTKPR---------KSTVG-TLFAVGGMDSTKGATSIEKYDLR 444
Cdd:PHA02790 222 ---NNVKWI--LDCTK-IFHCDKQPRKSYKYPFIEYPMNMDQiidifhmctSTHVGeVVYLIGGWMNNEIHNNAIAVNYI 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  445 TNMWTPVANMNGRRLQFGVAVLDDKLYVVGgrdGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD 524
Cdd:PHA02790 296 SNNWIPIPPMNSPRLYASGVPANNKLYVVG---GLPNPTSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVIGGHS 372

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  525 GWSylNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGgrdgssclKSVECFDPHTNKWTLCAQMSKRRGGVGV 604
Cdd:PHA02790 373 ETD--TTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVG--------RNAEFYCESSNTWTLIDDPIYPRDNPEL 442

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 55770880  605 TTWNGLLYAIGGHdapasnLTSRLSDCVERYDPKTDMW 642
Cdd:PHA02790 443 IIVDNKLLLIGGF------YRGSYIDTIEVYNNRTYSW 474

BTB_POZ_KLHL41_KBTBD10

cd18341

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

164-279

4.24e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349650 [Multi-domain] Cd Length: 133 Bit Score: 92.60 E-value: 4.24e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDN 243
Cdd:cd18341  18 LKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGN 97

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 55770880 244 IECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18341  98 VQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133

BACK_KLHL16_gigaxonin

cd18455

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...

273-361

7.40e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.

Pssm-ID: 350530 [Multi-domain] Cd Length: 97 Bit Score: 90.45 E-value: 7.40e-22

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 273 PSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQR 352
Cdd:cd18455   2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81


                ....*....
gi 55770880 353 RKDLSKLLA 361
Cdd:cd18455  82 KVHLKDLMS 90

BACK_KLHL10

cd18450

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...

271-348

8.04e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.

Pssm-ID: 350525 [Multi-domain] Cd Length: 80 Bit Score: 89.98 E-value: 8.04e-22

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVI-RNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHD 348
Cdd:cd18450   1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAkDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79

BACK_KLHL6

cd18446

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...

271-373

3.02e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.

Pssm-ID: 350521 [Multi-domain] Cd Length: 108 Bit Score: 89.06 E-value: 3.02e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18446   1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                        90       100
                ....*....|....*....|...
gi 55770880 351 QRRKDLSKLLAYIRLPLLAPQFL 373
Cdd:cd18446  81 ERLPLLPRVLENVRLPLLDPWYF 103

BTB_POZ_KLHL23

cd18252

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

175-278

8.19e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349561 [Multi-domain] Cd Length: 127 Bit Score: 88.73 E-value: 8.19e-21

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 175 DVILVAGDRRI-PAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACL 253
Cdd:cd18252  23 DITLQCASGQIfHCHKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADL 102

                        90       100
                ....*....|....*....|....*
gi 55770880 254 LQLSQVVEACCKFLMKQLHPSNCLG 278
Cdd:cd18252 103 LQFISVKKACEQFLVRHLDIDNCLG 127

BTB_POZ_KLHL15

cd18244

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-276

1.78e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349553 [Multi-domain] Cd Length: 137 Bit Score: 88.09 E-value: 1.78e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTAC 252
Cdd:cd18244  30 LLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQAAM 109

                        90       100
                ....*....|....*....|....
gi 55770880 253 LLQLSQVVEACCKFLMKQLHPSNC 276
Cdd:cd18244 110 YVQLTEVVKFCCSFLLAKICLDNC 133

BTB_POZ_KLHL34

cd18264

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

168-276

3.60e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349573 [Multi-domain] Cd Length: 136 Bit Score: 87.16 E-value: 3.60e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 168 LRH-KQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIEC 246
Cdd:cd18264  22 LRAeGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLED 101

                        90       100       110
                ....*....|....*....|....*....|
gi 55770880 247 LLSTACLLQLSQVVEACCKFLMKQLHPSNC 276
Cdd:cd18264 102 TLEAASYLQVTEAIGLCSQYLINNLAPENC 131

BACK_KLHL27_IPP

cd18466

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...

273-373

5.19e-20

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.

Pssm-ID: 350541 [Multi-domain] Cd Length: 103 Bit Score: 85.61 E-value: 5.19e-20

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 273 PSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQR 352
Cdd:cd18466   3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                        90       100
                ....*....|....*....|.
gi 55770880 353 RKDLSKLLAYIRLPLLAPQFL 373
Cdd:cd18466  83 KKHVVEVLEPVRFPLLPPQRL 103

BACK_KBTBD12

cd18485

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

271-370

1.35e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.

Pssm-ID: 350560 [Multi-domain] Cd Length: 100 Bit Score: 84.39 E-value: 1.35e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18485   1 MDASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRK 80

                        90       100
                ....*....|....*....|
gi 55770880 351 QRRKDLSKLLAYIRLPLLAP 370
Cdd:cd18485  81 SRVQHLVELLKQVRLELVSP 100

BTB2_POZ_KLHL33

cd18263

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

164-277

3.37e-19

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349572 [Multi-domain] Cd Length: 118 Bit Score: 83.71 E-value: 3.37e-19

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDN 243
Cdd:cd18263   4 IEGLWEKGVGCDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWEN 83

                        90       100       110
                ....*....|....*....|....*....|....
gi 55770880 244 IECLLSTACLLQLSQVVEACCKFLMKQLHPSNCL 277
Cdd:cd18263  84 LFEATCTALQLQISGALALCLDFLQREISPARCL 117

BTB_POZ_KLHL32

cd18261

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

146-277

1.08e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349570 [Multi-domain] Cd Length: 133 Bit Score: 82.71 E-value: 1.08e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 146 TSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSL 225
Cdd:cd18261   1 TGQRLCQSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGL 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 55770880 226 WSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCL 277
Cdd:cd18261  81 KQALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132

BTB_POZ_KLHL16_gigaxonin

cd18245

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

169-267

1.14e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349554 [Multi-domain] Cd Length: 111 Bit Score: 82.00 E-value: 1.14e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 169 RHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQE--EIKMEGVEPNSLWSLIQYAYTGRLELKEDNIEC 246
Cdd:cd18245  10 EEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGStyKIELEGISVEVMEEILDYIYTGQIKLSEDNIQD 89

                        90       100
                ....*....|....*....|.
gi 55770880 247 LLSTACLLQLSQVVEACCKFL 267
Cdd:cd18245  90 IVQAADLLLMTDLKDLCCEFL 110

BACK_KLHL24

cd18463

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...

270-347

1.22e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.

Pssm-ID: 350538 [Multi-domain] Cd Length: 78 Bit Score: 80.90 E-value: 1.22e-18

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55770880 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRH 347
Cdd:cd18463   1 QLDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78

BTB_POZ_KLHL11

cd18241

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

151-276

1.39e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349550 [Multi-domain] Cd Length: 135 Bit Score: 82.60 E-value: 1.39e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 151 FQALNHAEQTFKKMENYLRHKQLCDVILV---AGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKME------GVE 221
Cdd:cd18241   1 FECSSHCSELSWRQNEQRKQGLFCDITLAfggAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRkwssepGPD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 55770880 222 PNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNC 276
Cdd:cd18241  81 PDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135

BACK_KLHL25_ENC2

cd18514

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...

271-368

2.03e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).

Pssm-ID: 350589 [Multi-domain] Cd Length: 99 Bit Score: 80.66 E-value: 2.03e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18514   1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                        90
                ....*....|....*...
gi 55770880 351 QRRKDLSKLLAYIRLPLL 368
Cdd:cd18514  81 KRKDYLPELLRNVRLALL 98

BACK_KLHL37_ENC1

cd18515

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...

272-368

2.17e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350590 [Multi-domain] Cd Length: 98 Bit Score: 80.79 E-value: 2.17e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 272 HPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQ 351
Cdd:cd18515   1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                        90
                ....*....|....*..
gi 55770880 352 RRKDLSKLLAYIRLPLL 368
Cdd:cd18515  81 RHCYLSELLQTVRLALL 97

BTB_POZ_BTBD9

cd18287

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

164-267

2.99e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349596 [Multi-domain] Cd Length: 119 Bit Score: 81.13 E-value: 2.99e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL---K 240
Cdd:cd18287  13 IGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLTLtdlK 92

                        90       100
                ....*....|....*....|....*..
gi 55770880 241 EDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18287  93 EDVLLDVLGLAHQYGFEELEAAISDYL 119

BTB_POZ_KLHL31_KBTBD1

cd18260

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-277

3.99e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349569 [Multi-domain] Cd Length: 120 Bit Score: 80.63 E-value: 3.99e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARqeeIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTAC 252
Cdd:cd18260  18 LCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQR---VELNDISPLGLATVITYAYTGKLTLSLYTIGSTISAAS 94

                        90       100
                ....*....|....*....|....*
gi 55770880 253 LLQLSQVVEACCKFLMKQLHPSNCL 277
Cdd:cd18260  95 YLQIHALVKMCCDFLMQEMNVENCM 119

BACK_KLHL30

cd18469

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...

269-372

4.33e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.

Pssm-ID: 350544 [Multi-domain] Cd Length: 104 Bit Score: 80.19 E-value: 4.33e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 269 KQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHD 348
Cdd:cd18469   1 QQIDATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHD 80

                        90       100
                ....*....|....*....|....
gi 55770880 349 LEQRRKDLSKLLAYIRLPLLAPQF 372
Cdd:cd18469  81 PQARAAHLPELLSLVHLSLLTDQY 104

BACK_KLHL25_like

cd18464

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...

272-368

8.99e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.

Pssm-ID: 350539 [Multi-domain] Cd Length: 98 Bit Score: 79.08 E-value: 8.99e-18

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 272 HPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQ 351
Cdd:cd18464   1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                        90
                ....*....|....*..
gi 55770880 352 RRKDLSKLLAYIRLPLL 368
Cdd:cd18464  81 RHEVLPELLRSVRLALL 97

BACK_KBTBD8

cd18483

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

271-366

1.36e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.

Pssm-ID: 350558 [Multi-domain] Cd Length: 97 Bit Score: 75.67 E-value: 1.36e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18483   1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                        90
                ....*....|....*..
gi 55770880 351 QRRKDLSKLLAY-IRLP 366
Cdd:cd18483  81 KREMHLPEIFAKcIRMP 97

BTB_POZ_BAB-like

cd18315

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

173-257

1.43e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349624 [Multi-domain] Cd Length: 85 Bit Score: 74.89 E-value: 1.43e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTN-----DVrearqeEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECL 247
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtppdeHP------VIILPDVPYSELKALLDFIYTGEVNVSQEQLESL 74

                        90
                ....*....|
gi 55770880 248 LSTACLLQLS 257
Cdd:cd18315  75 LKLAELLQIK 84

BACK_KLHL40_KBTBD5

cd18516

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...

274-368

6.78e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.

Pssm-ID: 350591 [Multi-domain] Cd Length: 99 Bit Score: 73.64 E-value: 6.78e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 274 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRR 353
Cdd:cd18516   4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                        90
                ....*....|....*
gi 55770880 354 KDLSKLLAYIRLPLL 368
Cdd:cd18516  84 KALPVLLESIRFRLM 98

Kelch

Kelch domain;

563-609

7.54e-16

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 71.82 E-value: 7.54e-16

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 55770880    563 KLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNG 609
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

457-502

7.75e-16

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 71.87 E-value: 7.75e-16

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 55770880   457 RRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMS 502
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_trishanku-like

cd18314

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

171-263

8.73e-16

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349623 [Multi-domain] Cd Length: 96 Bit Score: 73.15 E-value: 8.73e-16

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 171 KQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLST 250
Cdd:cd18314   4 SEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLML 83

                        90
                ....*....|...
gi 55770880 251 ACLLQLSQVVEAC 263
Cdd:cd18314  84 ASKYQVPDLEKLC 96

Kelch

Kelch domain;

469-515

9.44e-16

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 71.44 E-value: 9.44e-16

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 55770880    469 KLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEG 515
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BACK_KLHL23

cd18462

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...

275-367

1.78e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.

Pssm-ID: 350537 [Multi-domain] Cd Length: 102 Bit Score: 72.46 E-value: 1.78e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 275 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRK 354
Cdd:cd18462   5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                        90
                ....*....|...
gi 55770880 355 DLSKLLAYIRLPL 367
Cdd:cd18462  85 CAYDLLSSIKLDL 97

BTB1_POZ_ABTB1_BPOZ1

cd18295

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

175-265

2.02e-15

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349604 [Multi-domain] Cd Length: 119 Bit Score: 73.05 E-value: 2.02e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTA--C 252
Cdd:cd18295  21 DVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHVDDVEDCKRLAkqC 100

                        90
                ....*....|....
gi 55770880 253 -LLQLSQVVEACCK 265
Cdd:cd18295 101 rLEELIEELEAKCK 114

BACK_KLHL21

cd18460

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...

271-368

2.49e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.

Pssm-ID: 350535 [Multi-domain] Cd Length: 101 Bit Score: 72.14 E-value: 2.49e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18460   1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                        90
                ....*....|....*...
gi 55770880 351 QRRKDLSKLLAYIRLPLL 368
Cdd:cd18460  81 HRQHFWPELLQHVRLPFV 98

BTB_POZ_KBTBD11

cd18275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

175-279

2.90e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349584 [Multi-domain] Cd Length: 104 Bit Score: 72.13 E-value: 2.90e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVrearqeeIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL 254
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDI-------LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                        90       100
                ....*....|....*....|....*
gi 55770880 255 QLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18275  79 QMPCAAQCAVDAVRAQLCLGNCYEV 103

BACK_KLHL7

cd18447

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...

270-367

3.42e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.

Pssm-ID: 350522 [Multi-domain] Cd Length: 98 Bit Score: 71.62 E-value: 3.42e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDL 349
Cdd:cd18447   1 QVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDE 80

                        90
                ....*....|....*...
gi 55770880 350 EQRRKDLSKLLAYIRLPL 367
Cdd:cd18447  81 PNRQPYMVDILAKVRFPL 98

BTB_POZ_BACH

cd18955

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-267

3.93e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349736 [Multi-domain] Cd Length: 94 Bit Score: 71.35 E-value: 3.93e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFT----NDVREARQEEIKMEGVEPnslwsLIQYAYTGRLELKEDNIECLL 248
Cdd:cd18955   1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVgqtdGDLVITLPEEVTVKGFEP-----LLQFAYTAKLLLSKENVLEVC 75

                        90
                ....*....|....*....
gi 55770880 249 STACLLQLSQVVEACCKFL 267
Cdd:cd18955  76 RCAEFLGVHNIEKACFDFL 94

BTB_POZ_KBTBD4

cd18272

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

164-279

4.80e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349581 [Multi-domain] Cd Length: 140 Bit Score: 72.62 E-value: 4.80e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDN 243
Cdd:cd18272  23 MDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEE 102

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 55770880 244 IECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 279
Cdd:cd18272 103 LQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138

BACK_calicin

cd18503

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...

275-347

7.64e-15

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.

Pssm-ID: 350578 [Multi-domain] Cd Length: 78 Bit Score: 70.07 E-value: 7.64e-15

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55770880 275 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRH 347
Cdd:cd18503   5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77

BACK_KLHL38

cd18476

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...

271-370

8.78e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.

Pssm-ID: 350551 [Multi-domain] Cd Length: 99 Bit Score: 70.54 E-value: 8.78e-15

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMnIPNEETILNALLTWVRHDLE 350
Cdd:cd18476   1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                        90       100
                ....*....|....*....|
gi 55770880 351 QRRKDLSKLLAYIRLPLLAP 370
Cdd:cd18476  80 ARKGYIHDLFKKVRLQYVHP 99

BTB2_POZ_RhoBTB

cd18300

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

173-271

2.11e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349609 [Multi-domain] Cd Length: 108 Bit Score: 69.58 E-value: 2.11e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRL-ELKEDNIECLLSTA 251
Cdd:cd18300   9 FSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQApILEDGDCVGLIVLA 88

                        90       100
                ....*....|....*....|
gi 55770880 252 CLLQLSQVVEACCKFLMKQL 271
Cdd:cd18300  89 NRLCLPRLVALCEQYIVKEL 108

PHA02713

hypothetical protein; Provisional

151-570

2.32e-14

hypothetical protein; Provisional

Pssm-ID: 165086 [Multi-domain] Cd Length: 557 Bit Score: 76.59 E-value: 2.32e-14

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  151 FQALNHAEQTFKKMENYLRHKQLCDVILVAGD-RRIPAHRLVLSSVSDYFAAMFTND-VREARQEEIKMEGVEPNSLWSL 228
Cdd:PHA02713   3 IDDIKHNRRVVSNISNLLDDDILCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPmIIRDLVTRVNLQMFDKDAVKNI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  229 IQYAYTgrLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIrsfadaqgctdLHKVahnYTMEHFMEVIR 308
Cdd:PHA02713  83 VQYLYN--RHISSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYM-----------YHRL---YEMSHIPIVKY 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  309 NQEFVLlpaSEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYirlpllapqfladMENNVLFRDDIEC 388
Cdd:PHA02713 147 IKRMLM---SNIPTLITTDAFKKTVFEILFDIISTNDNVYLYREGYKVTILLKW-------------LEYNYITEEQLLC 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  389 qklIMEAMKYHLLPER-RPMLQSPRT--------------KPRKSTVGTLFAVGGMDSTKGATS--IEKYDLRTNMWTPV 451
Cdd:PHA02713 211 ---ILSCIDIQNLDKKsRLLLYSNKTinmypsciqflldnKQNRNIIPRQLCLVCHDTKYNVCNpcILVYNINTMEYSVI 287

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  452 ANMNGRRLQFGVAVLDDKLYVVGGRD-GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLN 530
Cdd:PHA02713 288 STIPNHIINYASAIVDNEIIIAGGYNfNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVER 367

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 55770880  531 TVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR 570
Cdd:PHA02713 368 TIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGR 407

BTB_POZ_ZBTB24_ZNF450

cd18212

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-262

2.73e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349521 [Multi-domain] Cd Length: 118 Bit Score: 69.82 E-value: 2.73e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTnDVREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18212   6 HKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFA-DEGEVGQSIYMLEGMVAETFGALLEFIYTG 84

                        90       100
                ....*....|....*....|....*..
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEA 262
Cdd:cd18212  85 CLQVGEKSLEQILATAQFLKVNDLVKA 111

BACK_KLHL41_KBTBD10

cd18517

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...

271-369

2.79e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.

Pssm-ID: 350592 [Multi-domain] Cd Length: 99 Bit Score: 69.03 E-value: 2.79e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18517   1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                        90
                ....*....|....*....
gi 55770880 351 QRRKDLSKLLAYIRLPLLA 369
Cdd:cd18517  81 NRVKSLGEIFDCIRFRLMP 99

BTB2_POZ_BTBD8

cd18286

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

175-251

2.88e-14

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349595 [Multi-domain] Cd Length: 121 Bit Score: 69.60 E-value: 2.88e-14

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55770880 175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLEL-KEDNIECLLSTA 251
Cdd:cd18286  19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLpDDVNLGELLSLA 96

BTB_POZ_ZBTB5

cd18196

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-273

3.33e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349505 [Multi-domain] Cd Length: 126 Bit Score: 69.69 E-value: 3.33e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMeNYLR-HKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTndVREARQE----EIKMEGVEPNSLWSLIQ 230
Cdd:cd18196   4 HFEQIFQQL-NYQRlHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFT--VAEGDQTmnmiQLDSEVVTAEAFAALID 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 55770880 231 YAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 273
Cdd:cd18196  81 MMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 123

BACK_KLHL40_like

cd18477

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...

271-368

3.53e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.

Pssm-ID: 350552 [Multi-domain] Cd Length: 99 Bit Score: 68.71 E-value: 3.53e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18477   1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                        90
                ....*....|....*...
gi 55770880 351 QRRKDLSKLLAYIRLPLL 368
Cdd:cd18477  81 NRQKALPTVFESIRFRLL 98

BTB_POZ_ZBTB7A

cd18326

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-267

7.17e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349635 [Multi-domain] Cd Length: 120 Bit Score: 68.42 E-value: 7.17e-14

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTAC 252
Cdd:cd18326  25 LCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAAR 104

                        90
                ....*....|....*
gi 55770880 253 LLQLSQVVEACCKFL 267
Cdd:cd18326 105 LLEIPAVSHVCADLL 119

BACK_KBTBD2

cd18479

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...

275-365

1.15e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.

Pssm-ID: 350554 [Multi-domain] Cd Length: 96 Bit Score: 67.39 E-value: 1.15e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 275 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRK 354
Cdd:cd18479   5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQ 84

                        90
                ....*....|.
gi 55770880 355 DLSKLLAYIRL 365
Cdd:cd18479  85 YLSSVLSQIRI 95

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

551-596

1.33e-13

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 65.33 E-value: 1.33e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 55770880   551 PRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMS 596
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

Kelch

Kelch domain;

663-707

1.48e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 65.27 E-value: 1.48e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 55770880    663 KLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 707
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVI 45

BTB_POZ_ZBTB7C_ZBTB36

cd18328

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-267

1.84e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349637 [Multi-domain] Cd Length: 120 Bit Score: 67.60 E-value: 1.84e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18328   7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYT 86

                        90       100       110
                ....*....|....*....|....*....|...
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18328  87 STLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BACK

cd14733

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...

272-326

2.50e-13

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

Pssm-ID: 350515 [Multi-domain] Cd Length: 55 Bit Score: 64.99 E-value: 2.50e-13

                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 55770880 272 HPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLAS 326
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55

BACK_KLHL35

cd18474

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...

274-348

2.89e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.

Pssm-ID: 350549 [Multi-domain] Cd Length: 79 Bit Score: 65.60 E-value: 2.89e-13

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55770880 274 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHD 348
Cdd:cd18474   4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78

BTB_POZ_ZBTB7

cd18198

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-267

2.95e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349507 [Multi-domain] Cd Length: 120 Bit Score: 66.81 E-value: 2.95e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18198   7 DHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYT 86

                        90       100       110
                ....*....|....*....|....*....|...
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18198  87 ATLTVSTANVGDILSAARLLEIPCVSHVCAEIL 119

BTB_POZ_KLHL29_KBTBD9

cd18258

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-278

2.97e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349567 [Multi-domain] Cd Length: 125 Bit Score: 66.92 E-value: 2.97e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 158 EQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQE---EIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18258   2 KEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGeklELTMSNINADVLELLLEFVYT 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLG 278
Cdd:cd18258  82 GSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

652-695

3.96e-13

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 64.17 E-value: 3.96e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 55770880   652 RDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 695
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSM 45

BTB_POZ_ZBTB44

cd18228

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-267

4.41e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349537 [Multi-domain] Cd Length: 126 Bit Score: 66.42 E-value: 4.41e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMeNYLRHK-QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQ------------EEIKMEGVEP 222
Cdd:cd18228   2 HSQELLGKL-NSLRNEgHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVlvspagkcvldlHHVTVTGFAP 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 55770880 223 nslwsLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18228  81 -----LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFM 120

BTB_POZ_BTBD19

cd18294

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

164-267

6.01e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349603 [Multi-domain] Cd Length: 111 Bit Score: 65.73 E-value: 6.01e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 164 MENYLRHKQLCDVILVAGDRRIP--AHRLVLSSVSDYFAAMF-TNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELK 240
Cdd:cd18294   5 MKSLINNPEFSDVKFLVGPERQEifAHKCILAARCEVFRAMFlTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLS 84

                        90       100
                ....*....|....*....|....*..
gi 55770880 241 EDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18294  85 NHTVIEVLAAAVEYGLDELRKLCERFI 111

Kelch

Kelch domain;

518-562

6.72e-13

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 63.35 E-value: 6.72e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 55770880    518 YAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSG 562
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB28_BCL6B

cd18332

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

166-267

8.00e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349641 [Multi-domain] Cd Length: 114 Bit Score: 65.26 E-value: 8.00e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 166 NYLRHKQ-LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNI 244
Cdd:cd18332  11 NELRKRDiLTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTSRLPLTPRTV 90

                        90       100
                ....*....|....*....|...
gi 55770880 245 ECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18332  91 PAVLAAATYLQMEHVVETCRRFI 113

BTB_POZ_BACH1

cd18277

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-267

9.35e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349586 [Multi-domain] Cd Length: 120 Bit Score: 65.47 E-value: 9.35e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTN----DVREARQEEIKMEGVEPnslwsLIQY 231
Cdd:cd18277  10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGqadaELNITLPEEVTVKGFEP-----LIQF 84

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 55770880 232 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18277  85 AYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB_POZ_ZBTB32_FAZF_TZFP

cd18218

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

168-263

9.66e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349527 [Multi-domain] Cd Length: 110 Bit Score: 64.96 E-value: 9.66e-13

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 168 LRH-KQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNdvrEARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIEC 246
Cdd:cd18218  12 LRPaGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTN---PNPGQWCLGEGISPSTFKQLLDFVYGESVEVQPGELRP 88

                        90
                ....*....|....*..
gi 55770880 247 LLSTACLLQLSQVVEAC 263
Cdd:cd18218  89 LLEAARALEVESLEEAC 105

BACK_NS1BP_IVNS1ABP

cd18502

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...

271-362

2.51e-12

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.

Pssm-ID: 350577 Cd Length: 99 Bit Score: 63.41 E-value: 2.51e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDD-MNIPNEETILNALLTWVRHDL 349
Cdd:cd18502   1 LTPENCIGIRSFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESNQeLESINERKLCQLVLEWVQRSI 80

                        90
                ....*....|...
gi 55770880 350 EQRRKDLSKLLAY 362
Cdd:cd18502  81 EEGGLDLDDLTEK 93

BTB1_POZ_RhoBTB

cd18299

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

166-263

2.63e-12

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349608 [Multi-domain] Cd Length: 103 Bit Score: 63.38 E-value: 2.63e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 166 NYLRHKQLC-DVILVAGDR-RIPAHRLVLSSVSDYFAAMFTNdvrearQEEIKMEG-VEPNSLWSLIQYAYTGRLELKED 242
Cdd:cd18299   4 RNLLHSPSCaDVVFILQGGvRIFAHRIVLAAASSVFADLFLM------MTVVTLDSdITPEAFRRVLEFLYTGVLDENED 77

                        90       100
                ....*....|....*....|.
gi 55770880 243 NIECLLSTACLLQLSQVVEAC 263
Cdd:cd18299  78 DLKELKDAAELLELFDLVMMC 98

BTB_POZ_BTBD1_2

cd18281

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-275

3.72e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349590 [Multi-domain] Cd Length: 127 Bit Score: 63.99 E-value: 3.72e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAG----DRRIPAHRLVLSSVSDYFAAMFTNDVREaRQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 248
Cdd:cd18281  22 LSDVHFIVGkgdnEQRIPAHKFVLSIGSAVFDAMFNGGMAT-TSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTL 100

                        90       100
                ....*....|....*....|....*..
gi 55770880 249 STACLLQLSQVVEACCKFLMKQLHPSN 275
Cdd:cd18281 101 YTAKKYAVPALESACVEFLKKNLSSDN 127

BTB_POZ_Rank-5

cd18303

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

171-276

5.91e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349612 [Multi-domain] Cd Length: 120 Bit Score: 63.11 E-value: 5.91e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 171 KQLCDVILVAGDRRIPAHRLVLSSVSDYFAamFTNDvreARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIEC--LL 248
Cdd:cd18303  16 ELYSDITIKLADKSIPAHKFVLAARSEKWS--NENL---ASTNELDLSDISYEVVLALLRWLYTDELDLTLDDEFLleLM 90

                        90       100
                ....*....|....*....|....*...
gi 55770880 249 STACLLQLSQVVEACCKFLMKQLHPSNC 276
Cdd:cd18303  91 KAAKRFQLTDLVERCERALMSSVNVDNC 118

BTB_POZ_ZBTB47_ZNF651

cd18231

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

165-263

6.33e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349540 [Multi-domain] Cd Length: 115 Bit Score: 63.02 E-value: 6.33e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 165 ENYLRHKQLCDVILVAGDRR--IPAHRLVLSSVSDYFAAMFTNDvREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKED 242
Cdd:cd18231   6 EQRLFQPDLCDVDIVLVRQRstFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSLEALTSQGLQQILNFIYTSKLLVNSC 84

                        90       100
                ....*....|....*....|.
gi 55770880 243 NIECLLSTACLLQLSQVVEAC 263
Cdd:cd18231  85 NVQDVLNAAAVLQMNDIAASC 105

BTB_POZ_ZBTB19_PATZ1

cd18207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

151-263

9.03e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349516 [Multi-domain] Cd Length: 128 Bit Score: 62.67 E-value: 9.03e-12

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 151 FQALNHAEQTFKKMeNYLRHK--QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQ-EEIKMEGVEPNSLWS 227
Cdd:cd18207   4 YQVSQHSADMLHNL-NQQRKSggRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTpRELEMHTISSKVFGD 82

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 55770880 228 LIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEAC 263
Cdd:cd18207  83 ILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDIC 118

BTB_POZ_BTBD17

cd18292

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

157-266

1.30e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349601 [Multi-domain] Cd Length: 114 Bit Score: 61.92 E-value: 1.30e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 157 AEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTND-VREARQEEIkmEGVEPNSLWSL----IQY 231
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDwWSESKQSEI--ELVEDPECAAVfekfLRY 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 55770880 232 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKF 266
Cdd:cd18292  79 LYTGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113

BTB_POZ_BTBD18

cd18293

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

159-263

1.42e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349602 [Multi-domain] Cd Length: 120 Bit Score: 62.11 E-value: 1.42e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 159 QTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI-KMEGVEPNSLWSLIQYAYTGRL 237
Cdd:cd18293   1 TAFLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVlELQGLKAHTLLKLVDFLYTSEL 80

                        90       100
                ....*....|....*....|....*.
gi 55770880 238 ELKEDNIECLLSTACLLQLSQVVEAC 263
Cdd:cd18293  81 EVSSEEAQDVLAAARRLQISELESLC 106

Kelch

Kelch domain;

423-468

1.81e-11

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 59.49 E-value: 1.81e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 55770880    423 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDD 468
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ

cd01165

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

176-251

2.06e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

Pssm-ID: 349496 [Multi-domain] Cd Length: 79 Bit Score: 60.37 E-value: 2.06e-11

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55770880 176 VILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTA 251
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAA 76

BTB_POZ_GCL

cd18305

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

146-270

2.13e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349614 [Multi-domain] Cd Length: 115 Bit Score: 61.14 E-value: 2.13e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 146 TSDEFFQALnhaeqtFKKMENylrhkqlCDVILVAGDRRIPAHRLVLSSvSDYFAAMFTNDVREARQEEIKMEGVEPNSL 225
Cdd:cd18305   1 TSKYIYQTL------FLNGEN-------SDITICALGREWKLHKIYLCQ-SGYFASMFSGSWKESKETVINLEIPDDNIT 66

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 55770880 226 WSLIQYA----YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFlMKQ 270
Cdd:cd18305  67 VEALNVVfgslYRDEIEIKPSRVVSILAAATLLQLDGLIQQCSEV-MKE 114

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

504-549

2.37e-11

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 58.78 E-value: 2.37e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 55770880   504 HRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMS 549
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_calicin

cd18307

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

174-266

2.43e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349616 [Multi-domain] Cd Length: 97 Bit Score: 60.59 E-value: 2.43e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 174 CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQE---EIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLST 250
Cdd:cd18307   2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDElsiTIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKG 81

                        90
                ....*....|....*.
gi 55770880 251 ACLLQLSQVVEACCKF 266
Cdd:cd18307  82 AKYFNIPRLKDHCVDF 97

BTB_POZ_BTBD14B_NAC1

cd18290

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

174-269

2.63e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349599 [Multi-domain] Cd Length: 123 Bit Score: 61.21 E-value: 2.63e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 174 CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNdvreARQEEIKMEG-VEPNSLWSLIQYAYTGRLELKEDNIECLLSTAC 252
Cdd:cd18290  28 CDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPAaVQPQSFQQILSFCYTGRLSMNVGDQFLLMYTAG 103

                        90
                ....*....|....*..
gi 55770880 253 LLQLSQVVEACCKFLMK 269
Cdd:cd18290 104 FLQIQEIMEKGTEFFLK 120

BTB_POZ_ZBTB7B_ZBTB15

cd18327

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

144-267

3.86e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349636 [Multi-domain] Cd Length: 127 Bit Score: 61.01 E-value: 3.86e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 144 PCTSDEFFQALNhaEQtfkkmenylRHK-QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAR-------QEEI 215
Cdd:cd18327   6 PEHSSELLSCLN--EQ---------RRAgLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGdlgagggQDVC 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 55770880 216 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18327  75 ELDFVGPEALGALLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADIL 126

BTB_POZ_ZBTB27_BCL6

cd18331

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

166-267

4.27e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349640 [Multi-domain] Cd Length: 118 Bit Score: 60.64 E-value: 4.27e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 166 NYLRHKQ-LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTnDVREARQEEIKME-GVEPNSLWSLIQYAYTGRLELKEDN 243
Cdd:cd18331  16 NRLRSRDiLTDVVIVVSREQFRAHKTVLMACSGLFYSIFT-DQLKCNLSVINLDpEINPEGFNILLDFMYTSRLNLREGN 94

                        90       100
                ....*....|....*....|....
gi 55770880 244 IECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18331  95 IMAVMATAMYLQMEHVVDTCRKFI 118

BTB_POZ_BTBD6

cd18349

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

170-271

7.25e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349658 [Multi-domain] Cd Length: 109 Bit Score: 59.61 E-value: 7.25e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 170 HKQLCDVILVAG----DRRIPAHRLVLSSVSDYFAAMFTNDVREARQeEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 245
Cdd:cd18349   5 NELMADVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLAEVKS-EIHIPDVEPAAFLILLKYMYSDEIDLEADTVL 83

                        90       100
                ....*....|....*....|....*.
gi 55770880 246 CLLSTACLLQLSQVVEACCKFLMKQL 271
Cdd:cd18349  84 ATLYAAKKYIVPALAKACVNFLETSL 109

BTB_POZ_ZBTB27-like

cd18215

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-266

8.09e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349524 [Multi-domain] Cd Length: 113 Bit Score: 59.50 E-value: 8.09e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTAC 252
Cdd:cd18215  19 LTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYTSRLNLREGNIMAVMATAM 98

                        90
                ....*....|....
gi 55770880 253 LLQLSQVVEACCKF 266
Cdd:cd18215  99 YLQMEHVVDTCRKF 112

BTB_POZ_ZBTB3-like

cd18194

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-263

9.53e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349503 [Multi-domain] Cd Length: 128 Bit Score: 59.83 E-value: 9.53e-11

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFaAMFTNDvREARQEEIKMEG--VEPNSLWSLIQYAYTGRLELKEDNIECLLST 250
Cdd:cd18194  23 LCDCTVLVGSAQFPAHRAVLASCSMYF-HLFYRD-RLDKRDLVRLNSdiVTAPAFGLLLDFMYEGRLALRDLPVEDVLAA 100

                        90
                ....*....|...
gi 55770880 251 ACLLQLSQVVEAC 263
Cdd:cd18194 101 ASYLHMYDIVKVC 113

BTB_POZ_BACH2

cd18278

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-267

1.04e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349587 [Multi-domain] Cd Length: 124 Bit Score: 59.58 E-value: 1.04e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFT----NDVREARQEEIKMEGVEPnslwsLIQYAYTGRLELKEDNIECLL 248
Cdd:cd18278  31 LCDVTLIVEGKEFRAHRAVLAACSEYFLQALVgqteNDLVVSLPEEVTARGFGP-----LLQFAYTAKLLLSRENIQEVI 105

                        90
                ....*....|....*....
gi 55770880 249 STACLLQLSQVVEACCKFL 267
Cdd:cd18278 106 RCAEFLRMHNLEDSCFRFL 124

BACK_KLHL33

cd18472

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...

271-345

1.44e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.

Pssm-ID: 350547 [Multi-domain] Cd Length: 75 Bit Score: 57.78 E-value: 1.44e-10

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWV 345
Cdd:cd18472   1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75

BTB_POZ_ZBTB31_myoneurin

cd18217

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-263

1.53e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349526 [Multi-domain] Cd Length: 111 Bit Score: 58.61 E-value: 1.53e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMenylrHKQ-----LCDVILVAGDRRIPAHRLVLSSVSDYFAAMF---TNDVREARQEEIKMEGVEpnslwS 227
Cdd:cd18217   1 HCEQLLERL-----NKQreagfLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYkdtEDNIVFLDQSQVSADGFQ-----K 70

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 55770880 228 LIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEAC 263
Cdd:cd18217  71 LLEFIYTGNLNLDSWNVAEIHQAASYLGMEEVVAKC 106

BTB_POZ_ABTB2-like

cd18297

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

165-271

1.81e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349606 [Multi-domain] Cd Length: 117 Bit Score: 58.82 E-value: 1.81e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 165 ENYLRHKQLCDVI-LVAGdRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLE---LK 240
Cdd:cd18297   4 PHYVNNPEMSDVTfLVEG-RPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVA 82

                        90       100       110
                ....*....|....*....|....*....|.
gi 55770880 241 EDNIECLLSTACLLQLSQVVEACCKFLMKQL 271
Cdd:cd18297  83 QDDALELLRAASFFQLDGLKRHCEILLSQQI 113

PLN02193

nitrile-specifier protein

456-669

1.99e-10

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 63.82 E-value: 1.99e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  456 GRRLQFGVAVLDDKLYVVGGRdglKTLNT-----VECYNPKTKTWSVMPPMST--HRHGLGVAVLE--GPMYAVGGHDGW 526
Cdd:PLN02193 164 GLRCSHGIAQVGNKIYSFGGE---FTPNQpidkhLYVFDLETRTWSISPATGDvpHLSCLGVRMVSigSTLYVFGGRDAS 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  527 SYLNTVERWDPQARQWNFVATMS---TPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKR---RG 600
Cdd:PLN02193 241 RQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGDSfsiRG 320

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 55770880  601 GVGVTTWNGLLYAIGGHDAPASnltsrlsDCVERYDPKTDMWTAVASMSI---SRDAVGVCLLGDKLYAVGG 669
Cdd:PLN02193 321 GAGLEVVQGKVWVVYGFNGCEV-------DDVHYYDPVQDKWTQVETFGVrpsERSVFASAAVGKHIVIFGG 385

BTB_POZ_ZBTB21_ZNF295

cd18209

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

172-237

2.25e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349518 [Multi-domain] Cd Length: 112 Bit Score: 58.35 E-value: 2.25e-10

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 55770880 172 QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREArQEEIKMEGVEPNSLWSLIQYAYTGRL 237
Cdd:cd18209  17 QLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENES-QSVFQLDFCEPDAFENVLNYIYSSSL 81

BTB_POZ_ZBTB26_Bioref

cd18214

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

151-273

2.63e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349523 [Multi-domain] Cd Length: 122 Bit Score: 58.30 E-value: 2.63e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 151 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFT-NDVREARQEEIKMEGVEPNSLWSli 229
Cdd:cd18214   3 FRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLlNDSREVQISILQNSEVGRQLLLS-- 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 55770880 230 qyAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 273
Cdd:cd18214  81 --CYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122

BTB_POZ_ZBTB42

cd18956

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-274

2.79e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349737 [Multi-domain] Cd Length: 129 Bit Score: 58.67 E-value: 2.79e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFaAMFTNDVREARQEEIKMEG--VEPNSLWSLIQYAYTGRLELKEDNIECLLST 250
Cdd:cd18956  23 LCDCTVLVGDARFPAHRAVLAACSVYF-HLFYRDRPAGGRDTVRLNGdiVTAPAFGRLLDFMYEGRLDLRSLPVEDVLAA 101

                        90       100
                ....*....|....*....|....
gi 55770880 251 ACLLQLSQVVEAcCKFLMKQLHPS 274
Cdd:cd18956 102 ASYLHMYDIVKV-CKGRLREKDPA 124

BTB_POZ_KLHL14_printor

cd18243

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

141-275

3.49e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349552 [Multi-domain] Cd Length: 130 Bit Score: 58.51 E-value: 3.49e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 141 TMEPCTSDEFFQALNhaeqtfkkmenYLRHKQL-CDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDvrearqeEIKMEG 219
Cdd:cd18243  10 TFDPSHSDNLLHGLN-----------LLWRKQLfCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN-------NLVLQG 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 55770880 220 VEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 275
Cdd:cd18243  72 CSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127

PLN02193

nitrile-specifier protein

416-569

3.80e-10

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 62.67 E-value: 3.80e-10

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  416 RKSTVG-TLFAVGGMDSTKGATSIEKYDLRTNMW---TPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPK 491
Cdd:PLN02193 223 RMVSIGsTLYVFGGRDASRQYNGFYSFDTTTNEWkllTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIV 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  492 TKTW---SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSyLNTVERWDPQARQWNFVATMS---TPRSTVGVAVLSGKLY 565
Cdd:PLN02193 303 DKKWfhcSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQDKWTQVETFGvrpSERSVFASAAVGKHIV 381


                 ....
gi 55770880  566 AVGG 569
Cdd:PLN02193 382 IFGG 385

BTB_POZ_BTBD3_6

cd18282

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

175-271

4.66e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349591 [Multi-domain] Cd Length: 108 Bit Score: 57.41 E-value: 4.66e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 175 DVILVAGD----RRIPAHRLVLSSVSDYFAAMFTNDVREARQeEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLST 250
Cdd:cd18282   9 DVHFIVGPpggtQRIPAHKYVLATGSSVFYAMFYGGLAENKN-EIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYA 87

                        90       100
                ....*....|....*....|.
gi 55770880 251 ACLLQLSQVVEACCKFLMKQL 271
Cdd:cd18282  88 AKKYLVPHLARACVQFLETSL 108

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

598-649

9.29e-10

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 54.54 E-value: 9.29e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 55770880   598 RRGGVGVTTWNGLLYAIGGHDApasnltSRLSDCVERYDPKTDMWTAVASMS 649
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG------NQSLNSVEVYDPETNTWSKLPSMP 46

BTB_POZ_ZBTB46

cd18230

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-274

9.97e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349539 [Multi-domain] Cd Length: 125 Bit Score: 56.99 E-value: 9.97e-10

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI-KMEGVEPNSLWSLIQYAY 233
Cdd:cd18230   3 SHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVtHLDIVTAQGFKAIIDFMY 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 55770880 234 TGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPS 274
Cdd:cd18230  83 SAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123

BTB_POZ_ZBTB17_MIZ1

cd18206

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-266

1.51e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349515 [Multi-domain] Cd Length: 112 Bit Score: 56.09 E-value: 1.51e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMeNYLRH-KQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNdvreaRQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18206   5 HSQHVLEQL-NQQRQlGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVD-----QKDVVHLDISNAAGLGQVLEFMYT 78

                        90       100       110
                ....*....|....*....|....*....|..
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEACCKF 266
Cdd:cd18206  79 AKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

Kelch

Kelch domain;

610-662

1.59e-09

Kelch domain;

Pssm-ID: 128874 [Multi-domain] Cd Length: 47 Bit Score: 53.72 E-value: 1.59e-09

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 55770880    610 LLYAIGGHDaPASNLTSrlsdcVERYDPKTDMWTAVASMSISRDAVGVCLLGD 662
Cdd:smart00612   1 KIYVVGGFD-GGQRLKS-----VEVYDPETNKWTPLPSMPTPRSGHGVAVING 47

BTB_POZ_ZBTB49

cd18233

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-267

2.00e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349542 [Multi-domain] Cd Length: 112 Bit Score: 55.67 E-value: 2.00e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAR---QEEIKMEGvepnSLWSLIQYAYTGRLELKEDNIECLLS 249
Cdd:cd18233  18 LCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNdvfHLDIKNVG----GIGQILDFMYTSHLDLNQDNVQVMLD 93

                        90
                ....*....|....*...
gi 55770880 250 TACLLQLSQVVEACCKFL 267
Cdd:cd18233  94 IAQCLQVQNVLNMCYTFL 111

BTB_POZ_ZBTB12

cd18203

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

151-273

2.38e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349512 [Multi-domain] Cd Length: 122 Bit Score: 55.65 E-value: 2.38e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 151 FQALNHAEQTFKKMeNYLRHKQ-LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIkMEGvePNSLWSLI 229
Cdd:cd18203   3 FQLPGHEAATLRNM-NQLRSEErFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSL-MHS--SRVVADLL 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 55770880 230 QYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHP 273
Cdd:cd18203  79 LSCYTGALEFSVRDIVNYLTAASYLQMEHVVEKCRGALSQFIEP 122

BTB_POZ_BTBD1

cd18346

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

181-275

2.51e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349655 [Multi-domain] Cd Length: 133 Bit Score: 55.84 E-value: 2.51e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 181 GDRRIPAHRLVLSSVSDYFAAMFtNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVV 260
Cdd:cd18346  40 GAQRIPAHRFVLAAGSAVFDAMF-NGGMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 118

                        90
                ....*....|....*
gi 55770880 261 EACCKFLMKQLHPSN 275
Cdd:cd18346 119 AHCVEFLTKHLRADN 133

PLN02193

nitrile-specifier protein

441-590

2.68e-09

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 59.97 E-value: 2.68e-09

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  441 YDLRTNMWT--------PVANMNGRRLqfgVAVlDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMS---THRHGLG 509
Cdd:PLN02193 198 FDLETRTWSispatgdvPHLSCLGVRM---VSI-GSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEegpTPRSFHS 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  510 VAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMS---TPRSTVGVAVLSGKLYAVGGRDGSScLKSVECFDPHT 586
Cdd:PLN02193 274 MAADEENVYVFGGVSATARLKTLDSYNIVDKKWFHCSTPGdsfSIRGGAGLEVVQGKVWVVYGFNGCE-VDDVHYYDPVQ 352


                 ....
gi 55770880  587 NKWT 590
Cdd:PLN02193 353 DKWT 356

BTB_POZ_ZBTB18_2-like

cd18325

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-263

5.53e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349634 [Multi-domain] Cd Length: 128 Bit Score: 55.04 E-value: 5.53e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18325   5 DHSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFMYE 84

                        90       100
                ....*....|....*....|....*....
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEAC 263
Cdd:cd18325  85 GKLEFSSLPVEDVLAAASYLHMYDIVKVC 113

BTB_POZ_ZBTB18_RP58

cd18324

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

169-290

6.23e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349633 [Multi-domain] Cd Length: 147 Bit Score: 55.43 E-value: 6.23e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 169 RHKQ-LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECL 247
Cdd:cd18324  18 RHQGfLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDV 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 55770880 248 LSTACLLQLSQVVEACCKFLmKQLHPSNCLGIRSFADAQGCTD 290
Cdd:cd18324  98 LAAASYLHMYDIVKVCKKKL-KEKATTEADSTKKEEDASSCSD 139

BTB_POZ_BTBD2

cd18347

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-275

8.22e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349656 [Multi-domain] Cd Length: 127 Bit Score: 54.31 E-value: 8.22e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGD----RRIPAHRLVLSSVSDYFAAMFtNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 248
Cdd:cd18347  22 LSDVHFLVGKglgsQRIPAHRFVLAVGSAVFDAMF-NGGMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTL 100

                        90       100
                ....*....|....*....|....*..
gi 55770880 249 STACLLQLSQVVEACCKFLMKQLHPSN 275
Cdd:cd18347 101 YTAKKYAVPALEAHCVEFLKKNLRADN 127

BACK_KLHL31_KBTBD1

cd18470

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...

275-365

9.13e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).

Pssm-ID: 350545 Cd Length: 98 Bit Score: 53.34 E-value: 9.13e-09

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 275 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDlEQRRK 354
Cdd:cd18470   5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83

                        90
                ....*....|.
gi 55770880 355 DLSKLLAYIRL 365
Cdd:cd18470  84 YAADLLSNIRF 94

BTB_POZ_BTBD3

cd18348

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

180-275

1.27e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349657 [Multi-domain] Cd Length: 131 Bit Score: 53.87 E-value: 1.27e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 180 AGDRRIPAHRLVLSSVSDYFAAMFTNDVREARqEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQV 259
Cdd:cd18348  32 GGTQRLPGHKYVLAVGSSVFHAMFYGELAEDK-DEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHL 110

                        90
                ....*....|....*.
gi 55770880 260 VEACCKFLMKQLHPSN 275
Cdd:cd18348 111 ARACVNFLETSLSAKN 126

BTB_POZ_ZBTB29_HIC1

cd18333

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-269

1.96e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349642 [Multi-domain] Cd Length: 121 Bit Score: 52.98 E-value: 1.96e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDvreaRQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18333   3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHD----NLINLDHEMVSPGIFRLILDYIYT 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 55770880 235 GRL----ELKEDNIECLLSTACLLQLSQVVEACCKFLMK 269
Cdd:cd18333  79 GRLsegdPGSEQNLGAVLAAASYLQIPDLVALCKKKLKR 117

BTB_POZ_SPOP-like

cd18279

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

164-236

2.23e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349588 [Multi-domain] Cd Length: 120 Bit Score: 52.92 E-value: 2.23e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 55770880 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGR 236
Cdd:cd18279   9 LGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGK 81

Kelch_6

Kelch motif;

458-501

2.28e-08

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 50.80 E-value: 2.28e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 55770880   458 RLQFGVAVLDDKLYVVGGR-DGLKTLNTVECYNPKTKTWSVMPPM 501
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPL 46

BTB_POZ_roadkill-like

cd18345

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

166-236

2.57e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349654 [Multi-domain] Cd Length: 121 Bit Score: 52.54 E-value: 2.57e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 55770880 166 NYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGR 236
Cdd:cd18345  11 LLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81

BTB_POZ_BPM_plant

cd18280

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

168-237

2.63e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349589 [Multi-domain] Cd Length: 121 Bit Score: 52.72 E-value: 2.63e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 168 LRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRL 237
Cdd:cd18280   9 LESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDEL 78

BACK_KLHL11

cd18451

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...

271-354

2.64e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.

Pssm-ID: 350526 [Multi-domain] Cd Length: 88 Bit Score: 51.88 E-value: 2.64e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLE 350
Cdd:cd18451   1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                ....
gi 55770880 351 QRRK 354
Cdd:cd18451  81 ERER 84

BTB_POZ_ZBTB8A_BOZF1

cd18329

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-267

3.39e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349638 [Multi-domain] Cd Length: 116 Bit Score: 52.13 E-value: 3.39e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDV-ILVAGdRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI-KMEGVEPNSLWSLIQYAY 233
Cdd:cd18329   4 HQSRLLQQLDEQRKQELFCDCsILVEG-QVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVaTFDVFSPDTFTIILDFVY 82

                        90       100       110
                ....*....|....*....|....*....|....
gi 55770880 234 TGRLELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18329  83 SGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BACK_KLHL26

cd18465

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...

276-368

3.40e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.

Pssm-ID: 350540 Cd Length: 97 Bit Score: 51.83 E-value: 3.40e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDlEQRRKD 355
Cdd:cd18465   6 CLNIGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRAS 84

                        90
                ....*....|...
gi 55770880 356 LSKLLAYIRLPLL 368
Cdd:cd18465  85 ASHVLCHIRFPLM 97

BTB2_POZ_ABTB1_BPOZ1

cd18296

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

175-271

4.28e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349605 [Multi-domain] Cd Length: 121 Bit Score: 51.91 E-value: 4.28e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQE-----EIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLS 249
Cdd:cd18296  19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLY 98

                        90       100
                ....*....|....*....|..
gi 55770880 250 TACLLQLSQVVEACCKFLMKQL 271
Cdd:cd18296  99 VADMYLLPGLKRLCGTVLAQSL 120

BTB_POZ_ZBTB30_HIC2

cd18334

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-269

4.65e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349643 [Multi-domain] Cd Length: 120 Bit Score: 51.89 E-value: 4.65e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDvreaRQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18334   3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLHD----NLINLDTDMVNPTVFRQILDFIYT 78

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 55770880 235 GRL----ELKEDNIECLLSTACLLQLSQVVEACCKFLMK 269
Cdd:cd18334  79 GKLltsdQPGEQNFNALLTAASYLQLHDLAALCRKKLKR 117

BTB_POZ_ETO1-like

cd18190

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

175-266

4.81e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349499 [Multi-domain] Cd Length: 83 Bit Score: 50.98 E-value: 4.81e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKME--GVEPNSLWSLIQYAYTGRLELKEDNIecllstac 252
Cdd:cd18190   1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEenGISIEAMRAVIDFSVTGRLDLFSVEN-------- 72

                        90
                ....*....|....
gi 55770880 253 llqLSQVVEACCKF 266
Cdd:cd18190  73 ---VHEVLELASKF 83

BTB_POZ_ARIA_plant

cd18352

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

165-251

4.95e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349661 [Multi-domain] Cd Length: 116 Bit Score: 51.71 E-value: 4.95e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 165 ENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMegvePNSLW----SLIQYAYTGRLELK 240
Cdd:cd18352   5 EQYVNNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEI----PNIRWevfeLMMRFIYTGSVDIT 80

                        90
                ....*....|.
gi 55770880 241 EDNIECLLSTA 251
Cdd:cd18352  81 NDIAKDLLRAA 91

BTB_POZ_ZBTB16_PLZF

cd18205

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-267

5.05e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349514 [Multi-domain] Cd Length: 107 Bit Score: 51.57 E-value: 5.05e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDvrearQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTAC 252
Cdd:cd18205  18 LCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRN-----SQHYTLDFLSPKTFQQILEYAYTATLQAKVEDLDDLLYAAE 92

                        90
                ....*....|....*
gi 55770880 253 LLQLSQVVEACCKFL 267
Cdd:cd18205  93 ILEIEYLEEQCLKIL 107

BTB2_POZ_LZTR1

cd18309

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

162-235

5.90e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349618 [Multi-domain] Cd Length: 126 Bit Score: 52.01 E-value: 5.90e-08

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55770880 162 KKMENYLRH--KQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN--SLWSLIQYAYTG 235
Cdd:cd18309   7 QDMEAFLESvgGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNISIGEMVPSrqAFDSLLRYIYYG 84

BTB_POZ_CP190-like

cd18311

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

162-261

6.53e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349620 [Multi-domain] Cd Length: 110 Bit Score: 51.43 E-value: 6.53e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 162 KKMENYLRHKQLCDVILVAGD-RRIPAHRLVLSSVSDYFAAM-----FTNDVREArQEEIKMEGVEPnslwsLIQYAYTG 235
Cdd:cd18311   3 QRLQNLFNKTEYCDLTLQFRDnEQLKVHRLVLSACTDYFNVLeqtceIVDDTLIM-PNELQADAVVP-----VINFMYTG 76

                        90       100
                ....*....|....*....|....*.
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVE 261
Cdd:cd18311  77 QLEFEEKSYGKLLRTAKELNMTVLLK 102

BTB_POZ_RCBTB1_2

cd18298

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

175-269

7.32e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349607 [Multi-domain] Cd Length: 108 Bit Score: 51.10 E-value: 7.32e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLL 254
Cdd:cd18298  14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLANSY 93

                        90
                ....*....|....*
gi 55770880 255 QLSQVVEACCKFLMK 269
Cdd:cd18298  94 CEERLKKLCEDIIKQ 108

BTB_POZ_ARMC5

cd18191

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

176-267

8.98e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349500 [Multi-domain] Cd Length: 100 Bit Score: 50.58 E-value: 8.98e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 176 VILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLE--LKEDNIECLLSTACL 253
Cdd:cd18191   5 RFLLDGGTQLPASRAALTGASEVFRAMLEGGFAEAQQDLVPLRQVPSGAFLPVLHYLHGCRGCdaNEDDEKSDQSPEGDL 84

                        90
                ....*....|....*.
gi 55770880 254 LQ--LSQVVEACCKFL 267
Cdd:cd18191  85 MKssLGQTLEVAGRFL 100

BTB_POZ_ZBTB8B

cd18330

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-263

9.91e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349639 [Multi-domain] Cd Length: 113 Bit Score: 50.70 E-value: 9.91e-08

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA-RQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTA 251
Cdd:cd18330  18 FCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSgRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAA 97

                        90
                ....*....|..
gi 55770880 252 CLLQLSQVVEAC 263
Cdd:cd18330  98 SYLQMTDVVNFC 109

BTB_POZ_ZBTB39

cd18224

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

152-263

1.05e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349533 [Multi-domain] Cd Length: 123 Bit Score: 50.99 E-value: 1.05e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 152 QALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTN-DVREARQEEIKMegVEPNSLWSLIQ 230
Cdd:cd18224   5 HSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLStELDVARTYVVDF--ITPANFEKVLS 82

                        90       100       110
                ....*....|....*....|....*....|...
gi 55770880 231 YAYTGRLELKEDNIECLLSTACLLQLSQVVEAC 263
Cdd:cd18224  83 FIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115

BTB_POZ_ZBTB43

cd18227

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-267

1.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349536 [Multi-domain] Cd Length: 121 Bit Score: 50.71 E-value: 1.16e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFA--AMFTNDVRearqeeIKMEGV-EPNSLWSLIQY 231
Cdd:cd18227   7 DFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCdqVLLKNSRR------IVLPDVmNPRVFENILLS 80

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 55770880 232 AYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18227  81 CYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BTB_POZ_ZBTB8

cd18199

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

174-267

1.90e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349508 [Multi-domain] Cd Length: 113 Bit Score: 50.11 E-value: 1.90e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 174 CDV-ILVAGdRRIPAHRLVLSSVSDYFAAMFTNDVREA-RQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTA 251
Cdd:cd18199  19 CDCsIIVEG-RIFKAHRNVLFASSGYFRMLLSHYIQDTgRPSTASFDVFSSDAFSIILDFVYSGKLSLTSQNVIEVMSAA 97

                        90
                ....*....|....*.
gi 55770880 252 CLLQLSQVVEACCKFL 267
Cdd:cd18199  98 SYLQMTDVINVCKTFI 113

BTB_POZ_ZBTB37

cd18222

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

166-267

2.16e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349531 [Multi-domain] Cd Length: 123 Bit Score: 50.04 E-value: 2.16e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 166 NYLRHK-QLCDVILVAGDRRIPAHRLVLSSVSDYFA-AMFTNDVREARQEEIKmegvEPNSLWSLIQYAYTGRLELKEDN 243
Cdd:cd18222  17 NQLRMQgRLCDIVVNVQGQSFRAHKVVLAASSPYFRdHMSLNEMSTVSISVIK----NPTVFEQLLSFCYTGRICLQLAD 92

                        90       100
                ....*....|....*....|....
gi 55770880 244 IECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18222  93 IISYLTAASFLQMQHIIDKCTQIL 116

BACK_KLHL9_13

cd18449

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...

275-366

2.27e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.

Pssm-ID: 350524 [Multi-domain] Cd Length: 95 Bit Score: 49.34 E-value: 2.27e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 275 NCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDlEQRRK 354
Cdd:cd18449   5 NCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQ 83

                        90
                ....*....|..
gi 55770880 355 DLSKLLAYIRLP 366
Cdd:cd18449  84 FAAKLMENIRFP 95

BTB_POZ_BTBD14A_NAC2

cd18289

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

172-273

2.94e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349598 [Multi-domain] Cd Length: 131 Bit Score: 50.03 E-value: 2.94e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 172 QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEikmEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTA 251
Cdd:cd18289  28 LYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELP---ATVPPACFQQILSFCYTGKLTMAASEQLVVMYTA 104

                        90       100
                ....*....|....*....|..
gi 55770880 252 CLLQLSQVVEACCKFLMKQLHP 273
Cdd:cd18289 105 GFLQIQHIVERGTDLMFKVSSP 126

BTB_POZ_ZBTB3

cd18323

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-267

3.11e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349632 [Multi-domain] Cd Length: 128 Bit Score: 49.83 E-value: 3.11e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFaAMFTNDVREARQEE-IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTA 251
Cdd:cd18323  23 LCDCTVLVGSTQFLAHRAVLASCSPFF-HMFYKEQLDKRDLVcINNEIVTAPAFSLLLEFMYEGRLSFNDTPVEDVLAAA 101

                        90
                ....*....|....*.
gi 55770880 252 CLLQLSQVVEACCKFL 267
Cdd:cd18323 102 SYLHMNDIVKVCKKRL 117

PLN02153

epithiospecifier protein

416-569

4.40e-07

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 52.68 E-value: 4.40e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  416 RKSTVGT-LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGR-----RLQFGVAVLDDKLYVVGG--RDGLKT----LN 483
Cdd:PLN02153  80 RMVAVGTkLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGvsKGGLMKtperFR 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  484 TVECYNPKTKTWSVMPPMSTH---RHGLGVAVLEGPMYAV---------GGHDGWSYlNTVERWDPQARQWNFVATMS-- 549
Cdd:PLN02153 160 TIEAYNIADGKWVQLPDPGENfekRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWTEVETTGak 238

                        170       180
                 ....*....|....*....|.
gi 55770880  550 -TPRSTVGVAVLSGKLYAVGG 569
Cdd:PLN02153 239 pSARSVFAHAVVGKYIIIFGG 259

BTB_POZ_ZBTB22_BING1

cd18210

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

172-267

5.05e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349519 [Multi-domain] Cd Length: 112 Bit Score: 48.68 E-value: 5.05e-07

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 172 QLCDVILVAGDRRIPAHRLVLSSVSDYFAamftNDVREARQEEIKMEGV-EPNSLWSLIQYAYTGRLELKEDNIECLLST 250
Cdd:cd18210  20 KLCDISIHVQGRVFRAHRAVLAASSPYFH----DQVLLKNMSSISLPGVmDPGAFESVLASAYTGKLTMLADEIVNYLTV 95

                        90
                ....*....|....*..
gi 55770880 251 ACLLQLSQVVEACCKFL 267
Cdd:cd18210  96 GSVLQMWHIVDKCTELL 112

PLN02193

nitrile-specifier protein

509-692

6.34e-07

nitrile-specifier protein

Pssm-ID: 177844 [Multi-domain] Cd Length: 470 Bit Score: 52.65 E-value: 6.34e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  509 GVAVLEGPMYAVGGH-------DGWSYLntverWDPQARQWNFV-ATMSTPR-STVGVAVLS--GKLYAVGGRDGSSCLK 577
Cdd:PLN02193 170 GIAQVGNKIYSFGGEftpnqpiDKHLYV-----FDLETRTWSISpATGDVPHlSCLGVRMVSigSTLYVFGGRDASRQYN 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  578 SVECFDPHTNKWTLCAQMSK---RRGGVGVTTWNGLLYAIGGHDApasnlTSRLsDCVERYDPKTDMW----TAVASMSI 650
Cdd:PLN02193 245 GFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGGVSA-----TARL-KTLDSYNIVDKKWfhcsTPGDSFSI 318

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 55770880  651 sRDAVGVCLLGDKLYAVGGYDGqAYLNTVEAYDPQTNEWTQV 692
Cdd:PLN02193 319 -RGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQV 358

PLN02153

epithiospecifier protein

456-647

7.95e-07

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 51.91 E-value: 7.95e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  456 GRRLQFGVAVLDDKLYVVGGRdgLKTLNTVE----CYNPKTKTWSVMPP------MSThrHGLGVAVLEGPMYAVGGHDG 525
Cdd:PLN02153  21 GPRCSHGIAVVGDKLYSFGGE--LKPNEHIDkdlyVFDFNTHTWSIAPAngdvprISC--LGVRMVAVGTKLYIFGGRDE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  526 WSYLNTVERWDPQARQWNFVATMST-----PRSTVGVAVLSGKLYAVGGRDGSSCLK------SVECFDPHTNKWtlcAQ 594
Cdd:PLN02153  97 KREFSDFYSYDTVKNEWTFLTKLDEeggpeARTFHSMASDENHVYVFGGVSKGGLMKtperfrTIEAYNIADGKW---VQ 173

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55770880  595 MS------KRRGGVGVTTWNGLLYAI---------GGHDAPASNltsrlsdCVERYDPKTDMWTAVAS 647
Cdd:PLN02153 174 LPdpgenfEKRGGAGFAVVQGKIWVVygfatsilpGGKSDYESN-------AVQFFDPASGKWTEVET 234

BTB_POZ_SPOPL

cd18343

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

164-275

1.10e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349652 [Multi-domain] Cd Length: 123 Bit Score: 48.08 E-value: 1.10e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDN 243
Cdd:cd18343  12 LGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKM 91

                        90       100       110
                ....*....|....*....|....*....|..
gi 55770880 244 IECLLSTACLLQLSQVVEACCKFLMKQLHPSN 275
Cdd:cd18343  92 ADNLLAAADKYALERLKVMCEEALCNNLSVEN 123

BTB_POZ_ZBTB11

cd18202

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-263

1.55e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349511 [Multi-domain] Cd Length: 118 Bit Score: 47.54 E-value: 1.55e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEE-IKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18202   2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAvVDLSGFCKSSFLPLLEFAYT 81

                        90       100
                ....*....|....*....|....*....
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVEAC 263
Cdd:cd18202  82 SELTFDFCSMAEVAMLARHLFMNEVLEIC 110

BTB_POZ_ZBTB48_TZAP_KR3

cd18232

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

172-266

1.64e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349541 [Multi-domain] Cd Length: 108 Bit Score: 47.06 E-value: 1.64e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 172 QLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVepnsLWSLIQYAYTGRLELKEDNIECLLSTA 251
Cdd:cd18232  17 QYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEV----FGLLLDFFYTGELALTRENRDRVLLAA 92

                        90
                ....*....|....*
gi 55770880 252 CLLQLSQVVEACCKF 266
Cdd:cd18232  93 KELRVPEAVELCQRF 107

Kelch_3

pfam13415

Galactose oxidase, central domain;

661-705

2.67e-06

Galactose oxidase, central domain;

Pssm-ID: 433188 [Multi-domain] Cd Length: 49 Bit Score: 44.59 E-value: 2.67e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 55770880   661 GDKLYAVGGYD--GQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVV 705
Cdd:pfam13415   1 GDKLYIFGGLGfdGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47

BTB_POZ_ZBTB29-like

cd18216

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-267

2.95e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349525 [Multi-domain] Cd Length: 118 Bit Score: 46.76 E-value: 2.95e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDvreaRQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18216   2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHD----NLIHLDQDMVSPTVFQQILDFIYT 77

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 55770880 235 GRL---ELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18216  78 GKLldsLFEEPNLSEVLAAANYLQLPDLAALCRSKL 113

PLN02153

epithiospecifier protein

411-590

3.13e-06

epithiospecifier protein

Pssm-ID: 177814 [Multi-domain] Cd Length: 341 Bit Score: 49.98 E-value: 3.13e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  411 PRTKPRKSTVG-TLFAVGGmdSTKGATSIEK----YDLRTNMWTpVANMNG---RRLQFGV--AVLDDKLYVVGGRDGLK 480
Cdd:PLN02153  22 PRCSHGIAVVGdKLYSFGG--ELKPNEHIDKdlyvFDFNTHTWS-IAPANGdvpRISCLGVrmVAVGTKLYIFGGRDEKR 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  481 TLNTVECYNPKTKTWSVMPPMSTH-----RHGLGVAVLEGPMYAVGGHDGWSYLNTVER------WDPQARQWnfvATMS 549
Cdd:PLN02153  99 EFSDFYSYDTVKNEWTFLTKLDEEggpeaRTFHSMASDENHVYVFGGVSKGGLMKTPERfrtieaYNIADGKW---VQLP 175

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 55770880  550 TP------RSTVGVAVLSGKLYAV---------GGRDGSSClKSVECFDPHTNKWT 590
Cdd:PLN02153 176 DPgenfekRGGAGFAVVQGKIWVVygfatsilpGGKSDYES-NAVQFFDPASGKWT 230

BACK_KLHL32_BKLHD5

cd18471

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...

271-368

3.42e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.

Pssm-ID: 350546 [Multi-domain] Cd Length: 98 Bit Score: 46.05 E-value: 3.42e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRN--QEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHD 348
Cdd:cd18471   1 LNSFNYLDLYKLADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN 80

                        90       100
                ....*....|....*....|
gi 55770880 349 LeqRRKDLSKLLAYIRLPLL 368
Cdd:cd18471  81 C--RYQYMDELLQYVRFGLM 98

PRK14131

N-acetylneuraminate epimerase;

583-706

4.10e-06

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 49.63 E-value: 4.10e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  583 DPHtNKWTLCAQM--SKRRGGVGVTTwNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVAS---MSISrDAVGV 657
Cdd:PRK14131  59 APS-KGWTKIAAFpgGPREQAVAAFI-DGKLYVFGGIGKTNSEGSPQVFDDVYKYDPKTNSWQKLDTrspVGLA-GHVAV 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  658 CLLGDKLYAVGGY-----DG-------------------QAYLNT----------VEAYDPQTNEWTQ--VAPLcLGRAG 701
Cdd:PRK14131 136 SLHNGKAYITGGVnknifDGyfedlaaagkdktpkdkinDAYFDKkpedyffnkeVLSYDPSTNQWKNagESPF-LGTAG 214


                 ....*
gi 55770880  702 ACVVT 706
Cdd:PRK14131 215 SAVVI 219

Kelch_1

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

421-455

4.28e-06

Pssm-ID: 396078 [Multi-domain] Cd Length: 46 Bit Score: 44.14 E-value: 4.28e-06

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 55770880   421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMN 455
Cdd:pfam01344  12 GKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46

Kelch_6

Kelch motif;

652-695

4.29e-06

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 44.25 E-value: 4.29e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 55770880   652 RDAVGVCLLGDKLYAVGGYDGQA-YLNTVEAYDPQTNEWTQVAPL 695
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASpALNKLEVYNPLTKSWEELPPL 46

BTB_POZ_ZBTB9

cd18200

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

164-267

4.31e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349509 [Multi-domain] Cd Length: 111 Bit Score: 46.00 E-value: 4.31e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 164 MENYLRHK---QLCDVILVAGDRRIPAHRLVLSSVSDYFA-AMFTNDVREARQEEIkmegVEPNSLWSLIQYAYTGRLEL 239
Cdd:cd18200   6 LETLNKHRlegKFCDLSVHVQGRVFRAHKAVLAASSPYFHdKLLLNDTNCLVLPSV----IEAAAFENLLQLIYSGRLTL 81

                        90       100
                ....*....|....*....|....*...
gi 55770880 240 KEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18200  82 CMDALPSHLLVASGLQMWQVVDRCSELL 109

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

457-501

6.08e-06

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 43.86 E-value: 6.08e-06

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 55770880   457 RRLQFGVAVLDDKLYVVGGRDGLK--TLNTVECYNPKTKTWSVMPPM 501
Cdd:pfam07646   1 PRYPHASSVPGGKLYVVGGSDGLGdlSSSDVLVYDPETNVWTEVPRL 47

BTB_POZ_ZBTB10

cd18201

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-272

8.53e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349510 [Multi-domain] Cd Length: 122 Bit Score: 45.72 E-value: 8.53e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEE--IKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLST 250
Cdd:cd18201  21 LCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTtvTHLDVVAVQGFSVILDFMYSGNLVLTSQNAIEVMSV 100

                        90       100
                ....*....|....*....|..
gi 55770880 251 ACLLQLSQVVEACCKFLMKQLH 272
Cdd:cd18201 101 ASYLQMTEVVQSCRNFIKDALN 122

BTB_POZ_BTBD11

cd18351

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

158-277

8.58e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349660 [Multi-domain] Cd Length: 131 Bit Score: 45.74 E-value: 8.58e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 158 EQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDvREARQEEIKMEGVEPNSLWSLIQYAYTG-- 235
Cdd:cd18351   9 KQTSRLDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNK-PSAENTCIEISYVKYHIFQLVMQYLYCGgt 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 55770880 236 -RLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCL 277
Cdd:cd18351  88 eSLLIKNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130

BTB_POZ_KLHL42

cd18319

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

176-255

8.71e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349628 [Multi-domain] Cd Length: 93 Bit Score: 44.86 E-value: 8.71e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 176 VILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRL--------ELKEDN--IE 245
Cdd:cd18319   4 VQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLRGLSAPGLELVLDFINTSKVhesqgdstDTLEENelLE 83

                        90
                ....*....|
gi 55770880 246 CLLSTACLLQ 255
Cdd:cd18319  84 DLVEAASFLQ 93

BTB_POZ_ZBTB34

cd18220

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

166-267

8.75e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349529 [Multi-domain] Cd Length: 120 Bit Score: 45.40 E-value: 8.75e-06

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 166 NYLR-HKQLCDVILVAGDRRIPAHRLVLSSVSDYF---AAMFTndvrearqeeikMEGVE------PNSLWSLIQYAYTG 235
Cdd:cd18220  17 NELRlQGKLCDIIVHIQGQPFRAHKAVLAASSPYFrdhSALST------------MSGLSisviknPNVFEQLLSFCYTG 84

                        90       100       110
                ....*....|....*....|....*....|..
gi 55770880 236 RLELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18220  85 RMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BTB1_POZ_IBtk

cd18301

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

175-235

8.83e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349610 [Multi-domain] Cd Length: 99 Bit Score: 44.97 E-value: 8.83e-06

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 55770880 175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTND----VREARQEEIKMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18301  20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSlltsEDAVGCDVVHIEKVPPEIFEQLLQFIYTD 84

BTB2_POZ_RHOBTB3

cd18360

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

173-271

1.12e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349669 [Multi-domain] Cd Length: 110 Bit Score: 44.84 E-value: 1.12e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT------GRLELKednieC 246
Cdd:cd18360  10 LADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTdsccpaSILQAM-----A 84

                        90       100
                ....*....|....*....|....*
gi 55770880 247 LLSTACLLQLSQVVEACCKFLMKQL 271
Cdd:cd18360  85 LLICAEMYQVSRLQHICELYIITQL 109

Kelch_4

pfam13418

Galactose oxidase, central domain;

456-501

1.14e-05

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 42.98 E-value: 1.14e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 55770880   456 GRRLQFGVAVLDDKLYVVGGRDGL-KTLNTVECYNPKTKTWSVMPPM 501
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGSL 47

BTB_POZ_SPOP

cd18342

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

170-275

1.58e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349651 [Multi-domain] Cd Length: 125 Bit Score: 44.71 E-value: 1.58e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 170 HKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLS 249
Cdd:cd18342  19 NSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLA 98

                        90       100
                ....*....|....*....|....*.
gi 55770880 250 TACLLQLSQVVEACCKFLMKQLHPSN 275
Cdd:cd18342  99 AADKYALERLKVMCEDALCSNLSVEN 124

BTB_POZ_ZBTB14

cd18204

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

161-265

1.65e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349513 [Multi-domain] Cd Length: 114 Bit Score: 44.64 E-value: 1.65e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 161 FKKMENYLR-HKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREArQEEIKMEGVEPNSLWSLIQYAYTGRLEL 239
Cdd:cd18204   5 FLKTLNEQRlEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDS-SSVIEIDFLRSDIFEEVLNYMYTAKISV 83

                        90       100
                ....*....|....*....|....*.
gi 55770880 240 KEDNIECLLSTACLLQLSQVVEACCK 265
Cdd:cd18204  84 KKEDVNLMMSSGQILGIRFLDKLCSQ 109

BTB_POZ_ZBTB40

cd18225

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-271

1.66e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349534 [Multi-domain] Cd Length: 116 Bit Score: 44.43 E-value: 1.66e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNdvreARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18225   5 NYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDS----TDTISIDASVVSPEEFALLLEMVYT 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVeACCKFLMKQL 271
Cdd:cd18225  81 GKLPPGKHNFTKIISVADSLQMFDVA-VSCKNLLTSL 116

BTB_POZ_ZBTB41

cd18226

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

161-261

1.70e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349535 [Multi-domain] Cd Length: 114 Bit Score: 44.41 E-value: 1.70e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 161 FKKMENYLRHKQ--LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTndvREARQEEIKMEGVEPNSLWSLIQYAYTGRLE 238
Cdd:cd18226   8 LLKYLNDDRQKQssFCDLVITVEGKEFSAHKVVVAVGSSYFHACLS---KNPNTDAVTLDHVSYSVFQHLLEFLYTSEFF 84

                        90       100
                ....*....|....*....|...
gi 55770880 239 LKEDNIECLLSTACLLQLSQVVE 261
Cdd:cd18226  85 VYENEIPLVLEAAKFLDIIDAVK 107

BTB_POZ_ZBTB6

cd18197

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

151-267

1.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349506 [Multi-domain] Cd Length: 116 Bit Score: 44.48 E-value: 1.76e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 151 FQALNHAEQTFKKMeNYLRHKQL-CDVILVAGDRRIPAHRLVLSSVSDYFAAMFT-NDVREARQEEIKMEGVEPNSLWSl 228
Cdd:cd18197   3 FKFEQQGDAVLQKM-NLLRQQNLfCDVSIYINDTEFHGHKVILAACSTFMRDQFLlNQSKQVRITILQSAEVGRKLLLS- 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 55770880 229 iqyAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Cdd:cd18197  81 ---CYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116

BTB_POZ_ZBTB1

cd18192

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

155-261

2.57e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349501 [Multi-domain] Cd Length: 114 Bit Score: 44.04 E-value: 2.57e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18192   3 SHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMYL 82

                        90       100
                ....*....|....*....|....*..
gi 55770880 235 GRLELKEDNIECLLSTACLLQLSQVVE 261
Cdd:cd18192  83 GKIMTAPSDFEQLKVAMNYLQLYYIPE 109

Kelch_2

pfam07646

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...

652-695

2.65e-05

Pssm-ID: 462220 [Multi-domain] Cd Length: 47 Bit Score: 41.94 E-value: 2.65e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 55770880   652 RDAVGVCLLGDKLYAVGGYDGQ--AYLNTVEAYDPQTNEWTQVAPL 695
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTEVPRL 47

BACK_KBTBD6_7

cd18482

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...

274-364

2.95e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.

Pssm-ID: 350557 [Multi-domain] Cd Length: 99 Bit Score: 43.26 E-value: 2.95e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 274 SNCLGIRSFADAQGCTDLHKVAHNYTMEHF-MEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQR 352
Cdd:cd18482   4 SNCAGILKFADAFDNRELKSKALAFIARNFqQLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKER 83

                        90
                ....*....|..
gi 55770880 353 RKDLSKLLAYIR 364
Cdd:cd18482  84 AASAAEVLKCVR 95

BTB_POZ_ZBTB23_GZF1

cd18211

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

173-263

2.96e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349520 [Multi-domain] Cd Length: 128 Bit Score: 44.07 E-value: 2.96e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 173 LCDVILVA---GDRR-IPAHRLVLSSVSDYFAAMFTND-VREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECL 247
Cdd:cd18211  25 LCDVTVQVehqGSKEeFSAHKAVLAASSKYFKEVFLNEkISDGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRM 104

                        90
                ....*....|....*.
gi 55770880 248 LSTACLLQLSQVVEAC 263
Cdd:cd18211 105 LEIAEKLKCLDLSETC 120

BTB_POZ_ZBTB4

cd18195

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

172-239

3.17e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349504 [Multi-domain] Cd Length: 124 Bit Score: 44.11 E-value: 3.17e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 172 QLCDVILVAGDRRIPAHRLVLSSVSDYF-------------AAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLE 238
Cdd:cd18195  17 LFCDVTLIAGDTKFRAHRSVLAASSPYFrellssplplgaaAVAAAPGATQSPERVLELPGVKAGVFSDVLNFIYSSRVA 96


                .
gi 55770880 239 L 239
Cdd:cd18195  97 L 97

BTB_POZ_NPR_plant

cd18310

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...

177-279

4.06e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349619 [Multi-domain] Cd Length: 145 Bit Score: 44.22 E-value: 4.06e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 177 ILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA--RQEEIKMEGVEP------NSLWSLIQYAYTGRLELkedniecLL 248
Cdd:cd18310  23 IIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGanTKPKLELRELIPggivgyDAFMLVLSYLYSGRLRL-------VP 95

                        90       100       110
                ....*....|....*....|....*....|....*
gi 55770880 249 STACLLQLSQVVEACCK----FLMKQLHPSNCLGI 279
Cdd:cd18310  96 KEGSACVDSDCWHVACRpavdFALEVLYAASVFQI 130

Kelch_6

Kelch motif;

551-599

4.81e-05

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 41.17 E-value: 4.81e-05

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 55770880   551 PRSTVGVAVLSGKLYAVGGR-DGSSCLKSVECFDPHTNKWTLCAQMSKRR 599
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB2_POZ_RHOBTB2

cd18359

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

175-261

6.41e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349668 [Multi-domain] Cd Length: 124 Bit Score: 43.07 E-value: 6.41e-05

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 175 DVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKED----NIECLLST 250
Cdd:cd18359  22 DVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQFSSSPDlddmKLIILANR 101

                        90
                ....*....|.
gi 55770880 251 ACLLQLSQVVE 261
Cdd:cd18359 102 LCLPHLVALTE 112

Kelch_4

pfam13418

Galactose oxidase, central domain;

653-695

6.80e-05

Galactose oxidase, central domain;

Pssm-ID: 433191 [Multi-domain] Cd Length: 49 Bit Score: 40.67 E-value: 6.80e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 55770880   653 DAVGVCLLGDKLYAVGGYDGQA-YLNTVEAYDPQTNEWTQVAPL 695
Cdd:pfam13418   4 YHTSTSIPDDTIYLFGGEGEDGtLLSDLWVFDLSTNEWTRLGSL 47

PRK14131

N-acetylneuraminate epimerase;

434-522

1.01e-04

N-acetylneuraminate epimerase;

Pssm-ID: 237617 [Multi-domain] Cd Length: 376 Bit Score: 45.39 E-value: 1.01e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880  434 GATSIEKYDLRT--NMWTPVANMNG-RRLQFGVAVLDDKLYVVGG-----RDG-LKTLNTVECYNPKTKTWSVM---PPM 501
Cdd:PRK14131  48 AGTSWYKLDLNApsKGWTKIAAFPGgPREQAVAAFIDGKLYVFGGigktnSEGsPQVFDDVYKYDPKTNSWQKLdtrSPV 127

                         90       100
                 ....*....|....*....|.
gi 55770880  502 STHRHgLGVAVLEGPMYAVGG 522
Cdd:PRK14131 128 GLAGH-VAVSLHNGKAYITGG 147

BTB_POZ_ZBTB35_ZNF131

cd18221

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...

156-262

1.18e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349530 [Multi-domain] Cd Length: 113 Bit Score: 41.91 E-value: 1.18e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEeikMEGVEPNSLWSLIQYAYTG 235
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVE---IEGVSNMAFRHLIEFTYTA 77

                        90       100
                ....*....|....*....|....*...
gi 55770880 236 RLELK-EDNIECLLSTACLLQLSQVVEA 262
Cdd:cd18221  78 KLMVQgEEEANDVWKAAEYLQMQEAIKA 105

BTB2_POZ_IBtk

cd18302

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

170-263

1.79e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349611 [Multi-domain] Cd Length: 113 Bit Score: 41.58 E-value: 1.79e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 170 HKQLCDVILVAGD-RRIPAHRLVLSSVSDYFAAMFTNDVRE-ARQEEIKMEG----VEPnslwsLIQYAYTGRLE-LKE- 241
Cdd:cd18302   2 HSDLYDVTIVSEDgKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTMPIpsdiLEI-----ILDYLYTDEASaVKEs 76

                        90       100
                ....*....|....*....|....*
gi 55770880 242 DNIECL---LSTACLLQLSQVVEAC 263
Cdd:cd18302  77 QNVEFLcnvLVIADQLLITRLKEIC 101

Kelch_6

Kelch motif;

604-652

2.21e-04

Kelch motif;

Pssm-ID: 404790 [Multi-domain] Cd Length: 50 Bit Score: 39.24 E-value: 2.21e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 55770880   604 VTTWNGLLYAIGGHDAPasnltSRLSDCVERYDPKTDMWTAVASMSISR 652
Cdd:pfam13964   7 VVSVGGYIYVFGGYTNA-----SPALNKLEVYNPLTKSWEELPPLPTPR 50

BTB1_POZ_KLHL33

cd18262

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

156-251

2.42e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349571 [Multi-domain] Cd Length: 101 Bit Score: 40.65 E-value: 2.42e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNdvREARQEEIKMEgVEPNSLWSLIQYAYTG 235
Cdd:cd18262   1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLFRERLLG--SNGPLPPLSLE-VTPVGWEAVLTFAYTG 77

                        90
                ....*....|....*.
gi 55770880 236 RLELKEDNIECLLSTA 251
Cdd:cd18262  78 VLGRNPATVGDILVAA 93

BACK_KLHL34

cd18473

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs ...

271-373

3.98e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 34 (KLHL34); KLHL34 belongs to the KLHL family. Its function remains unclear. The methylation status of KLHL34 cg14232291 may be a predictive candidate of sensitivity to preoperative chemoradiation therapy.

Pssm-ID: 350548 Cd Length: 106 Bit Score: 40.49 E-value: 3.98e-04

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 55770880 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQ----EFVLLPASEIAKLLASDDMNIPNEETILNALLTWVR 346
Cdd:cd18473   1 LSPENCCFSANIAARFGLPDALKAAEKYIISNLWRLLASDaddaGLLELNLESLQAVLEADDIPRVKESRLLTLVLEWLN 80

                        90       100
                ....*....|....*....|....*..
gi 55770880 347 HDlEQRRKDLSKLLAYIRLPLLAPQFL 373
Cdd:cd18473  81 QD-ESRLAYANALLSRIRYGLVPVEEL 106

BTB1_POZ_BTBD8

cd18285

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...

168-234

4.10e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

Pssm-ID: 349594 [Multi-domain] Cd Length: 104 Bit Score: 40.41 E-value: 4.10e-04

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 55770880 168 LRHKQLCDVILVAGDRRIPAHRLVL-SSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYT 234
Cdd:cd18285  10 LREELHTDVTFYVGSTLFKAHKAILlARVPEFFSHIIGKLSSLEDQEPINIENLEASEFKTFLRQVYT 77

Kelch_6