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Conserved domains on  [gi|149944433|ref|NP_001012241|]
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male-specific lethal 1 homolog isoform 1 [Homo sapiens]

Protein Classification

MSL1 family protein( domain architecture ID 10633776)

MSL1 (male-specific lethal 1) family protein similar to vertebrate KAT8 regulatory NSL complex subunit 1 that as part of the NSL complex, is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEHE pfam15275
PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In ...
 210-337 4.49e-25

PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).


:

Pssm-ID: 464607  Cd Length: 128  Bit Score: 98.33  E-value: 4.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149944433  210 LAVPSWRDHSVEPLRDPNPS-DLLENLDDSVFSKRHAKLEldEKRRKRWDIQRIREQRILQRLQLRMYKKKGI--QESEP 286
Cdd:pfam15275   1 ILTPSWRVVDLNPLEDSEEDeDEIEDLSDEVFSKRHQKYE--EKERKRWDLWRIREQRRRESLRSRSYPSRNTpvPLGPQ 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 149944433  287 EVTSFFPEPDDVESlMITPFLPVVAfgRPLPKLTPQNFELPWLDERSRCRL 337
Cdd:pfam15275  79 PSSPFYPSPEDIED-QSVLEVPVQA--SPLPPLSPETSSLLSEEVQEWFSL 126
 
Name Accession Description Interval E-value
PEHE pfam15275
PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In ...
 210-337 4.49e-25

PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).


Pssm-ID: 464607  Cd Length: 128  Bit Score: 98.33  E-value: 4.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149944433  210 LAVPSWRDHSVEPLRDPNPS-DLLENLDDSVFSKRHAKLEldEKRRKRWDIQRIREQRILQRLQLRMYKKKGI--QESEP 286
Cdd:pfam15275   1 ILTPSWRVVDLNPLEDSEEDeDEIEDLSDEVFSKRHQKYE--EKERKRWDLWRIREQRRRESLRSRSYPSRNTpvPLGPQ 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 149944433  287 EVTSFFPEPDDVESlMITPFLPVVAfgRPLPKLTPQNFELPWLDERSRCRL 337
Cdd:pfam15275  79 PSSPFYPSPEDIED-QSVLEVPVQA--SPLPPLSPETSSLLSEEVQEWFSL 126
 
Name Accession Description Interval E-value
PEHE pfam15275
PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In ...
 210-337 4.49e-25

PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).


Pssm-ID: 464607  Cd Length: 128  Bit Score: 98.33  E-value: 4.49e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 149944433  210 LAVPSWRDHSVEPLRDPNPS-DLLENLDDSVFSKRHAKLEldEKRRKRWDIQRIREQRILQRLQLRMYKKKGI--QESEP 286
Cdd:pfam15275   1 ILTPSWRVVDLNPLEDSEEDeDEIEDLSDEVFSKRHQKYE--EKERKRWDLWRIREQRRRESLRSRSYPSRNTpvPLGPQ 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 149944433  287 EVTSFFPEPDDVESlMITPFLPVVAfgRPLPKLTPQNFELPWLDERSRCRL 337
Cdd:pfam15275  79 PSSPFYPSPEDIED-QSVLEVPVQA--SPLPPLSPETSSLLSEEVQEWFSL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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