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Conserved domains on  [gi|61656180|ref|NP_001013393|]
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U3 small nucleolar RNA-associated protein 18 homolog [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
238-535 8.93e-28

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 8.93e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 238 RPANAERPTTARISSVQFHPGAQVVMVSGVDNAISLFQVDgkTNPKIQSIYLEKFPIFKACFSANGEeVLATSMHSKVLY 317
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 318 VYDMLAGKLIpvHQVRGlKEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKI-NGRIAASTFSSDSKRIYTY 396
Cdd:COG2319 188 LWDLATGKLL--RTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASG 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 397 SENGEVYVWDVNSRKCMnRFLDEGSLCGLSIAASKNGQYVACGSKSGVVNIYNQDSclqqtnPKPIKAIMNLVTGVTSLA 476
Cdd:COG2319 265 SADGTVRLWDLATGELL-RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT------GKLLRTLTGHTGAVRSVA 337

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61656180 477 FNPTTEILAVASRkmKEAVRLVHLPSCTVFSNFPVFKkstlSRVQTMDFSPRGGYFALG 535
Cdd:COG2319 338 FSPDGKTLASGSD--DGTVRLWDLATGELLRTLTGHT----GAVTSVAFSPDGRTLASG 390
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
238-535 8.93e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 8.93e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 238 RPANAERPTTARISSVQFHPGAQVVMVSGVDNAISLFQVDgkTNPKIQSIYLEKFPIFKACFSANGEeVLATSMHSKVLY 317
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 318 VYDMLAGKLIpvHQVRGlKEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKI-NGRIAASTFSSDSKRIYTY 396
Cdd:COG2319 188 LWDLATGKLL--RTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASG 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 397 SENGEVYVWDVNSRKCMnRFLDEGSLCGLSIAASKNGQYVACGSKSGVVNIYNQDSclqqtnPKPIKAIMNLVTGVTSLA 476
Cdd:COG2319 265 SADGTVRLWDLATGELL-RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT------GKLLRTLTGHTGAVRSVA 337

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61656180 477 FNPTTEILAVASRkmKEAVRLVHLPSCTVFSNFPVFKkstlSRVQTMDFSPRGGYFALG 535
Cdd:COG2319 338 FSPDGKTLASGSD--DGTVRLWDLATGELLRTLTGHT----GAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 250-488 1.86e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 1.86e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 250 ISSVQFHPGAQVVMVSGVDNAISLFqvDGKTNPKIQSIYLEKFPIFKACFSANGEeVLATSMHSKVLYVYDMLAGKLIPV 329
Cdd:cd00200  54 VRDVAASADGTYLASGSSDKTIRLW--DLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTT 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 330 hqVRGlKEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKI-NGRIAASTFSSDSKRIYTYSENGEVYVWDVN 408
Cdd:cd00200 131 --LRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 409 SRKCMNRFL-DEGSLCglSIAASKNGQYVACGSKSGVVNIYNQDSClqqtnpKPIKAIMNLVTGVTSLAFNPTTEILAVA 487
Cdd:cd00200 208 TGKCLGTLRgHENGVN--SVAFSPDGYLLASGSEDGTIRVWDLRTG------ECVQTLSGHTNSVTSLAWSPDGKRLASG 279


                .
gi 61656180 488 S 488
Cdd:cd00200 280 S 280
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 345-411 8.57e-04

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 41.56  E-value: 8.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61656180   345 VSPDGSFLL-ISGIAGFSHLLSMKTKELIGSMKINGRIAASTFSSDSKRIYTYSE-NGEVYVWDVNSRK 411
Cdd:TIGR03866 132 VSPDGKIVVnTSETTNMAHWIDTATYEIVDNTLVDARPRFAEFTADGKELWVSSEiGGTVTVIDVATRK 200
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
238-535 8.93e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 8.93e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 238 RPANAERPTTARISSVQFHPGAQVVMVSGVDNAISLFQVDgkTNPKIQSIYLEKFPIFKACFSANGEeVLATSMHSKVLY 317
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 318 VYDMLAGKLIpvHQVRGlKEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKI-NGRIAASTFSSDSKRIYTY 396
Cdd:COG2319 188 LWDLATGKLL--RTLTG-HTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASG 264

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 397 SENGEVYVWDVNSRKCMnRFLDEGSLCGLSIAASKNGQYVACGSKSGVVNIYNQDSclqqtnPKPIKAIMNLVTGVTSLA 476
Cdd:COG2319 265 SADGTVRLWDLATGELL-RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT------GKLLRTLTGHTGAVRSVA 337

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 61656180 477 FNPTTEILAVASRkmKEAVRLVHLPSCTVFSNFPVFKkstlSRVQTMDFSPRGGYFALG 535
Cdd:COG2319 338 FSPDGKTLASGSD--DGTVRLWDLATGELLRTLTGHT----GAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
190-547 1.01e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.31  E-value: 1.01e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 190 DWAEAGSKRRTSSDDESEEDEDDLLQRTGNFISTSTSLPRGILKMKNCRPANAERPTTARISSVQFHPGAQVVMVSGVDN 269
Cdd:COG2319  21 LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADG 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 270 AISLFQVDGKTNPKIQSIYLEkfPIFKACFSANGEeVLATSMHSKVLYVYDMLAGKLIpvHQVRGlKEKTVKQFEVSPDG 349
Cdd:COG2319 101 TVRLWDLATGLLLRTLTGHTG--AVRSVAFSPDGK-TLASGSADGTVRLWDLATGKLL--RTLTG-HSGAVTSVAFSPDG 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 350 SFLLISGIAGFSHLLSMKTKELIGSMKI-NGRIAASTFSSDSKRIYTYSENGEVYVWDVNSRKCMnRFLDEGSLCGLSIA 428
Cdd:COG2319 175 KLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL-RTLTGHSGSVRSVA 253

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 429 ASKNGQYVACGSKSGVVNIYNQDSclqqtnPKPIKAIMNLVTGVTSLAFNPTTEILAVASRKmkEAVRLVHLPSCTVFSN 508
Cdd:COG2319 254 FSPDGRLLASGSADGTVRLWDLAT------GELLRTLTGHSGGVNSVAFSPDGKLLASGSDD--GTVRLWDLATGKLLRT 325

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 61656180 509 FpvfkKSTLSRVQTMDFSPRGGYFALGNEKGRALMYRLH 547
Cdd:COG2319 326 L----TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
247-489 1.53e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 1.53e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 247 TARISSVQFHPGAQVVMVSGVDNAISLFQVDgkTNPKIQSIYLEKFPIFKACFSANGEeVLATSMHSKVLYVYDMLAGKL 326
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATGKL 238

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 327 IpvhQVRGLKEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMK-INGRIAASTFSSDSKRIYTYSENGEVYVW 405
Cdd:COG2319 239 L---RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 406 DVNSRKCMNRFLDEGSLCgLSIAASKNGQYVACGSKSGVVNIYNQDSclqqtnPKPIKAIMNLVTGVTSLAFNPTTEILA 485
Cdd:COG2319 316 DLATGKLLRTLTGHTGAV-RSVAFSPDGKTLASGSDDGTVRLWDLAT------GELLRTLTGHTGAVTSVAFSPDGRTLA 388


                ....
gi 61656180 486 VASR 489
Cdd:COG2319 389 SGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
247-449 3.89e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 3.89e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 247 TARISSVQFHPGAQVVMVSGVDNAISLFQVDgkTNPKIQSIYLEKFPIFKACFSANGEeVLATSMHSKVLYVYDMLAGKL 326
Cdd:COG2319 204 TGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGEL 280

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 327 IpvhQVRGLKEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKI-NGRIAASTFSSDSKRIYTYSENGEVYVW 405
Cdd:COG2319 281 L---RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 61656180 406 DVNSRKCMNRFLDEGSLCgLSIAASKNGQYVACGSKSGVVNIYN 449
Cdd:COG2319 358 DLATGELLRTLTGHTGAV-TSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 250-488 1.86e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 1.86e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 250 ISSVQFHPGAQVVMVSGVDNAISLFqvDGKTNPKIQSIYLEKFPIFKACFSANGEeVLATSMHSKVLYVYDMLAGKLIPV 329
Cdd:cd00200  54 VRDVAASADGTYLASGSSDKTIRLW--DLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTT 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 330 hqVRGlKEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKI-NGRIAASTFSSDSKRIYTYSENGEVYVWDVN 408
Cdd:cd00200 131 --LRG-HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 409 SRKCMNRFL-DEGSLCglSIAASKNGQYVACGSKSGVVNIYNQDSClqqtnpKPIKAIMNLVTGVTSLAFNPTTEILAVA 487
Cdd:cd00200 208 TGKCLGTLRgHENGVN--SVAFSPDGYLLASGSEDGTIRVWDLRTG------ECVQTLSGHTNSVTSLAWSPDGKRLASG 279


                .
gi 61656180 488 S 488
Cdd:cd00200 280 S 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 247-533 1.23e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 1.23e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 247 TARISSVQFHPGAQVVMVSGVDNAISLFQVDgkTNPKIQSIYLEKFPIFKACFSANGEEVLATSMhSKVLYVYDMLAGKL 326
Cdd:cd00200   9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLE--TGELLRTLKGHTGPVRDVAASADGTYLASGSS-DKTIRLWDLETGEC 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 327 IpvHQVRGlKEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMK-INGRIAASTFSSDSKRIYTYSENGEVYVW 405
Cdd:cd00200  86 V--RTLTG-HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 406 DVNSRKCMNRFLDEgSLCGLSIAASKNGQYVACGSKSGVVNIYNQDS--CLQQTNPKPikaimnlvTGVTSLAFNPTTEI 483
Cdd:cd00200 163 DLRTGKCVATLTGH-TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTgkCLGTLRGHE--------NGVNSVAFSPDGYL 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 61656180 484 LAVASRkmKEAVRL--VHLPSCTvfsnfPVFKKSTlSRVQTMDFSPRGGYFA 533
Cdd:cd00200 234 LASGSE--DGTIRVwdLRTGECV-----QTLSGHT-NSVTSLAWSPDGKRLA 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 247-449 4.03e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.83  E-value: 4.03e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 247 TARISSVQFHPGAQVVMVSGVDNAISLFQVDgkTNPKIQSIYLEKFPIFKACFSANGEeVLATSMHSKVLYVYDMLAGKL 326
Cdd:cd00200  93 TSYVSSVAFSPDGRILSSSSRDKTIKVWDVE--TGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKC 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 327 I---PVHqvrglkEKTVKQFEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMKI-NGRIAASTFSSDSKRIYTYSENGEV 402
Cdd:cd00200 170 VatlTGH------TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTI 243

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 61656180 403 YVWDVNSRKCMnrfldeGSLCG-----LSIAASKNGQYVACGSKSGVVNIYN 449
Cdd:cd00200 244 RVWDLRTGECV------QTLSGhtnsvTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
247-409 1.61e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 1.61e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 247 TARISSVQFHPGAQVVMVSGVDNAISLFQVDgkTNPKIQSIYLEKFPIFKACFSANGEeVLATSMHSKVLYVYDMLAGKL 326
Cdd:COG2319 246 SGSVRSVAFSPDGRLLASGSADGTVRLWDLA--TGELLRTLTGHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLATGKL 322

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 327 IPVHQVRGLKEKTVkqfEVSPDGSFLLISGIAGFSHLLSMKTKELIGSMK-INGRIAASTFSSDSKRIYTYSENGEVYVW 405
Cdd:COG2319 323 LRTLTGHTGAVRSV---AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTgHTGAVTSVAFSPDGRTLASGSADGTVRLW 399


                ....
gi 61656180 406 DVNS 409
Cdd:COG2319 400 DLAT 403
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
258-410 3.00e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 3.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 258 GAQVVMVSGVDNAISLFqvDGKTNPKIQSIYLEKFPIFkACFSANGEEVLATSMHSKVLYVYDMLAGKL---IPV-HQVR 333
Cdd:COG3391  79 GRRLYVANSGSGRVSVI--DLATGKVVATIPVGGGPRG-LAVDPDGGRLYVADSGNGRVSVIDTATGKVvatIPVgAGPH 155

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 334 GLkektvkqfEVSPDGSFLLISGIAGFS-----HLLSMKTKELIGSMKINGRIAASTFSSDSKRIY--------TYSENG 400
Cdd:COG3391 156 GI--------AVDPDGKRLYVANSGSNTvsvivSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYvanrgsntSNGGSN 227

                       170
                ....*....|
gi 61656180 401 EVYVWDVNSR 410
Cdd:COG3391 228 TVSVIDLATL 237
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
258-452 1.07e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 47.00  E-value: 1.07e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 258 GAQVVMVSGVDNAISLFQVDGKTNPKIQSIYLEKFPIFKACFSANGEEVLATSMHSKVLYVYDMLAGKLIPVHQVrglkE 337
Cdd:COG3391  34 GPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPV----G 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 338 KTVKQFEVSPDGSFLLISgiAGFSHLLS---MKTKELIGSMKINGRIAASTFSSDSKRIY-TYSENGE----VYVWDVNS 409
Cdd:COG3391 110 GGPRGLAVDPDGGRLYVA--DSGNGRVSvidTATGKVVATIPVGAGPHGIAVDPDGKRLYvANSGSNTvsviVSVIDTAT 187

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 61656180 410 RKcMNRFLDEGSLCgLSIAASKNGQ--YVACG------SKSGVVNIYNQDS 452
Cdd:COG3391 188 GK-VVATIPVGGGP-VGVAVSPDGRrlYVANRgsntsnGGSNTVSVIDLAT 236
PQQ_ABC_repeats TIGR03866
PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family ...
 345-411 8.57e-04

PQQ-dependent catabolism-associated beta-propeller protein; Members of this protein family consist of seven repeats each of the YVTN family beta-propeller repeat (see TIGR02276). Members occur invariably as part of a transport operon that is associated with PQQ-dependent catabolism of alcohols such as phenylethanol.


Pssm-ID: 274824 [Multi-domain]  Cd Length: 310  Bit Score: 41.56  E-value: 8.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61656180   345 VSPDGSFLL-ISGIAGFSHLLSMKTKELIGSMKINGRIAASTFSSDSKRIYTYSE-NGEVYVWDVNSRK 411
Cdd:TIGR03866 132 VSPDGKIVVnTSETTNMAHWIDTATYEIVDNTLVDARPRFAEFTADGKELWVSSEiGGTVTVIDVATRK 200
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
240-361 2.70e-03

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 40.27  E-value: 2.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61656180 240 ANAERPTTARISSVQFHPGAQVVMVS--GVDnAISLFQVDGKTNPkiqsiyLEKFPIFKA---------CFSANGEEV-L 307
Cdd:COG2706 142 PNPERQEGPHAHSVVFDPDGRFLYVPdlGTD-RIYVYRLDPATGK------LPEPPEVSLppgsgprhlAFHPNGRFAyV 214

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 61656180 308 ATSMHSKV-LYVYDMLAGKLIPVHQVRGLKEKTVKQF-----EVSPDGSFLLIS-----GIAGFS 361
Cdd:COG2706 215 INELDSTVsVYAYDAATGTLTLIQTVSTLPEDFTGENwaadiHISPDGRFLYVSnrghnSIAVFA 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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