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Conserved domains on  [gi|62739188|ref|NP_001014975|]
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complement factor H isoform b precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 10-262 1.49e-27

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 110.51  E-value: 1.49e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   10 LMLWAICVAEDCNELPPR------RNTeilTGSWSDQTYPEGTQAIYKCRPGYR--SLGNVIMVCRKGEWVALNplrKCQ 81
Cdd:PHA02927   9 LTLLGIGCVLSCCTIPSRpinmkfKNS---VETDANANYNIGDTIEYLCLPGYRkqKMGPIYAKCTGTGWTLFN---QCI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   82 KRPCGHPGDTPFGTFTLTGgnvFEYGVKAVYTCNEGYQLLGEI-NYRECDTDG---WTNDIPICEVVKCLPVTAPENGKI 157
Cdd:PHA02927  83 KRRCPSPRDIDNGQLDIGG---VDFGSSITYSCNSGYQLIGESkSYCELGSTGsmvWNPEAPICESVKCQSPPSISNGRH 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  158 VSSamepDREYHFGQAVRFVCNSGYKIEGDEEMHCSdDGFWSkEKPKCVEISCKSPDVINGSPISQ-KIIYKENERFQYK 236
Cdd:PHA02927 160 NGY----EDFYTDGSVVTYSCNSGYSLIGNSGVLCS-GGEWS-DPPTCQIVKCPHPTISNGYLSSGfKRSYSYNDNVDFK 233

                        250       260
                 ....*....|....*....|....*...
gi 62739188  237 CNMGYEYSERGDAVCT-ESGWRP-LPSC 262
Cdd:PHA02927 234 CKYGYKLSGSSSSTCSpGNTWQPeLPKC 261
PHA02954 super family cl31523
EEV membrane glycoprotein; Provisional
 203-444 1.49e-13

EEV membrane glycoprotein; Provisional


The actual alignment was detected with superfamily member PHA02954:

Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 71.27  E-value: 1.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  203 PKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYeYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLri 282
Cdd:PHA02954  14 PAVVYSTCTVPTMNNAKLTSTETSFNDKQKVTFTCDSGY-YSLDPNAVCETDKWKYENPCKKMCTVSDYVSELYDKPL-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  283 kHRTGDEITYQCRN--GFYPATRGNTakctSTGWIPAPRCTLKPCDYPDIKHGGLyhENMRRPYfpvAVGKYYSYYCDEH 360
Cdd:PHA02954  91 -YEVNSTITLICKDetKYFRCEEKNG----NTSWNDTVTCPNAECQPLQLEHGSC--QPVKEKY---SFGEHITINCDVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  361 FETPSGSYwdhIHCTQDGWSPAVPCLRKCYFPYLENGYNQnhGRKFVQGKSIDVACHPGYALPKAQTTvTCMENGWSPT- 439
Cdd:PHA02954 161 YEVIGASY---ISCTANSWNVIPSCQQKCDIPSLSNGLIS--GSTFSIGGVIHLSCKSGFTLTGSPSS-TCIDGKWNPVl 234


                 ....*
gi 62739188  440 PRCIR 444
Cdd:PHA02954 235 PICVR 239
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 10-262 1.49e-27

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 110.51  E-value: 1.49e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   10 LMLWAICVAEDCNELPPR------RNTeilTGSWSDQTYPEGTQAIYKCRPGYR--SLGNVIMVCRKGEWVALNplrKCQ 81
Cdd:PHA02927   9 LTLLGIGCVLSCCTIPSRpinmkfKNS---VETDANANYNIGDTIEYLCLPGYRkqKMGPIYAKCTGTGWTLFN---QCI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   82 KRPCGHPGDTPFGTFTLTGgnvFEYGVKAVYTCNEGYQLLGEI-NYRECDTDG---WTNDIPICEVVKCLPVTAPENGKI 157
Cdd:PHA02927  83 KRRCPSPRDIDNGQLDIGG---VDFGSSITYSCNSGYQLIGESkSYCELGSTGsmvWNPEAPICESVKCQSPPSISNGRH 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  158 VSSamepDREYHFGQAVRFVCNSGYKIEGDEEMHCSdDGFWSkEKPKCVEISCKSPDVINGSPISQ-KIIYKENERFQYK 236
Cdd:PHA02927 160 NGY----EDFYTDGSVVTYSCNSGYSLIGNSGVLCS-GGEWS-DPPTCQIVKCPHPTISNGYLSSGfKRSYSYNDNVDFK 233

                        250       260
                 ....*....|....*....|....*...
gi 62739188  237 CNMGYEYSERGDAVCT-ESGWRP-LPSC 262
Cdd:PHA02927 234 CKYGYKLSGSSSSTCSpGNTWQPeLPKC 261
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 203-444 1.49e-13

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 71.27  E-value: 1.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  203 PKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYeYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLri 282
Cdd:PHA02954  14 PAVVYSTCTVPTMNNAKLTSTETSFNDKQKVTFTCDSGY-YSLDPNAVCETDKWKYENPCKKMCTVSDYVSELYDKPL-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  283 kHRTGDEITYQCRN--GFYPATRGNTakctSTGWIPAPRCTLKPCDYPDIKHGGLyhENMRRPYfpvAVGKYYSYYCDEH 360
Cdd:PHA02954  91 -YEVNSTITLICKDetKYFRCEEKNG----NTSWNDTVTCPNAECQPLQLEHGSC--QPVKEKY---SFGEHITINCDVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  361 FETPSGSYwdhIHCTQDGWSPAVPCLRKCYFPYLENGYNQnhGRKFVQGKSIDVACHPGYALPKAQTTvTCMENGWSPT- 439
Cdd:PHA02954 161 YEVIGASY---ISCTANSWNVIPSCQQKCDIPSLSNGLIS--GSTFSIGGVIHLSCKSGFTLTGSPSS-TCIDGKWNPVl 234


                 ....*
gi 62739188  440 PRCIR 444
Cdd:PHA02954 235 PICVR 239
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 146-205 2.63e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 55.61  E-value: 2.63e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188    146 CLPVTAPENGKIVSSamepDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
Cdd:smart00032   1 CPPPPDIENGTVTSS----SGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 146-206 1.10e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 1.10e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62739188 146 CLPVTAPENGKIVSSamepDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
Cdd:cd00033   1 CPPPPVPENGTVTGS----KGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
146-205 1.72e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.27  E-value: 1.72e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   146 CLPVTAPENGKIVSsamePDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
Cdd:pfam00084   1 CPPPPDIPNGKVSA----TKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 389-443 1.85e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.37  E-value: 1.85e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62739188 389 CYFPY-LENGYNQNHGRKFVQGKSIDVACHPGYALpKAQTTVTCMENG-WSPT-PRCI 443
Cdd:cd00033   1 CPPPPvPENGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTENGgWSPPpPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 267-320 3.41e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 3.41e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 62739188    267 CDNPY-IPNGDYSPLRIKHRTGDEITYQCRNGFYPaTRGNTAKCTSTG-W-IPAPRC 320
Cdd:smart00032   1 CPPPPdIENGTVTSSSGTYSYGDTVTYSCDPGYTL-IGSSTITCLENGtWsPPPPTC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 10-262 1.49e-27

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 110.51  E-value: 1.49e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   10 LMLWAICVAEDCNELPPR------RNTeilTGSWSDQTYPEGTQAIYKCRPGYR--SLGNVIMVCRKGEWVALNplrKCQ 81
Cdd:PHA02927   9 LTLLGIGCVLSCCTIPSRpinmkfKNS---VETDANANYNIGDTIEYLCLPGYRkqKMGPIYAKCTGTGWTLFN---QCI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   82 KRPCGHPGDTPFGTFTLTGgnvFEYGVKAVYTCNEGYQLLGEI-NYRECDTDG---WTNDIPICEVVKCLPVTAPENGKI 157
Cdd:PHA02927  83 KRRCPSPRDIDNGQLDIGG---VDFGSSITYSCNSGYQLIGESkSYCELGSTGsmvWNPEAPICESVKCQSPPSISNGRH 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  158 VSSamepDREYHFGQAVRFVCNSGYKIEGDEEMHCSdDGFWSkEKPKCVEISCKSPDVINGSPISQ-KIIYKENERFQYK 236
Cdd:PHA02927 160 NGY----EDFYTDGSVVTYSCNSGYSLIGNSGVLCS-GGEWS-DPPTCQIVKCPHPTISNGYLSSGfKRSYSYNDNVDFK 233

                        250       260
                 ....*....|....*....|....*...
gi 62739188  237 CNMGYEYSERGDAVCT-ESGWRP-LPSC 262
Cdd:PHA02927 234 CKYGYKLSGSSSSTCSpGNTWQPeLPKC 261
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 112-320 7.43e-18

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 83.16  E-value: 7.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  112 YTCNEGY--QLLGEInYRECDTDGWTNdIPICEVVKCLPVTAPENGKIVSSAMEpdreyhFGQAVRFVCNSGYKIEGDEE 189
Cdd:PHA02927  52 YLCLPGYrkQKMGPI-YAKCTGTGWTL-FNQCIKRRCPSPRDIDNGQLDIGGVD------FGSSITYSCNSGYQLIGESK 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  190 MHC----SDDGFWSKEKPKCVEISCKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEE 264
Cdd:PHA02927 124 SYCelgsTGSMVWNPEAPICESVKCQSPPSIsNGRHNGYEDFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEWSDPPTCQI 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 62739188  265 KSCDNPYIPNGDYSP-LRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA-PRC 320
Cdd:PHA02927 204 VKCPHPTISNGYLSSgFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPElPKC 261
PHA02639 PHA02639
EEV host range protein; Provisional
 85-262 7.76e-15

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 74.70  E-value: 7.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   85 CGHPGDTPFGtFTLTGGNVFEYGVKAVYTCNEGYQLLGEiNYRECDTDG----WTNDIPICEVVKCLPVTAPENGKIVSS 160
Cdd:PHA02639  22 CDKPDDISNG-FITELMEKYEIGKLIEYTCNTDYALIGD-RFRTCIKDKnnaiWSNKAPFCMLKECNDPPSIINGKIYNK 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  161 amepdRE-YHFGQAVRFVCNS----GYKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDV----INGSPISQKIIYKenE 231
Cdd:PHA02639 100 -----REmYKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKSWKPDPPICKMINCRFPALqngyINGIPSNKKFYYK--T 172

                        170       180       190
                 ....*....|....*....|....*....|...
gi 62739188  232 RFQYKCNMGYEYSERGDAVCT-ESGWRP-LPSC 262
Cdd:PHA02639 173 RVGFSCKSGFDLVGEKYSTCNiNATWFPsIPTC 205
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 203-444 1.49e-13

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 71.27  E-value: 1.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  203 PKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYeYSERGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLri 282
Cdd:PHA02954  14 PAVVYSTCTVPTMNNAKLTSTETSFNDKQKVTFTCDSGY-YSLDPNAVCETDKWKYENPCKKMCTVSDYVSELYDKPL-- 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  283 kHRTGDEITYQCRN--GFYPATRGNTakctSTGWIPAPRCTLKPCDYPDIKHGGLyhENMRRPYfpvAVGKYYSYYCDEH 360
Cdd:PHA02954  91 -YEVNSTITLICKDetKYFRCEEKNG----NTSWNDTVTCPNAECQPLQLEHGSC--QPVKEKY---SFGEHITINCDVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  361 FETPSGSYwdhIHCTQDGWSPAVPCLRKCYFPYLENGYNQnhGRKFVQGKSIDVACHPGYALPKAQTTvTCMENGWSPT- 439
Cdd:PHA02954 161 YEVIGASY---ISCTANSWNVIPSCQQKCDIPSLSNGLIS--GSTFSIGGVIHLSCKSGFTLTGSPSS-TCIDGKWNPVl 234


                 ....*
gi 62739188  440 PRCIR 444
Cdd:PHA02954 235 PICVR 239
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 227-444 3.33e-12

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 66.60  E-value: 3.33e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  227 YKENERFQYKCNMGYEYSERGD--AVCTESGWRPLPSCEEKSCDNPY-IPNGDYSPLRIKHrtGDEITYQCRNGFYPATR 303
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPiyAKCTGTGWTLFNQCIKRRCPSPRdIDNGQLDIGGVDF--GSSITYSCNSGYQLIGE 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  304 GNT-AKCTSTG---WIP-APRCTLKPCDYPDIKHGGlYHENMRRPYfpvAVGKYYSYYCDEHFETPSGSywdHIHCTQDG 378
Cdd:PHA02927 122 SKSyCELGSTGsmvWNPeAPICESVKCQSPPSISNG-RHNGYEDFY---TDGSVVTYSCNSGYSLIGNS---GVLCSGGE 194

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62739188  379 WSPAVPC-LRKCYFPYLENGY-NQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPT-PRCIR 444
Cdd:PHA02927 195 WSDPPTCqIVKCPHPTISNGYlSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPElPKCVR 263
PHA02831 PHA02831
EEV host range protein; Provisional
 4-207 3.61e-11

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 63.47  E-value: 3.61e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188    4 LAKIICLML----WAICVAedcNELPPRRNTEIltgSWSDQTYPEGTQAIYKCRPGYRSlgnVIMVCRKGEWVALNplrK 79
Cdd:PHA02831   4 LTKIIILLFisktWCICVF---NKNDAKYSNVD---SYENKVYEENENLEYKCNNNFDK---VFVTCNNGSWSTKN---M 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   80 C-QKRPCGHPgdtpfgtFTLTGGNV------FEYGVKAVYTCN----EGYQLLGEINYReCDTDGWTNDIPICEVVKClP 148
Cdd:PHA02831  72 CiGKRNCKDP-------VTILNGYIknkkdqYSFGDSVTYACKvnklEKYSIVGNETVK-CINKQWVPKYPVCKLIRC-K 142

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 62739188  149 VTAPENGKIVSSamepDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVE 207
Cdd:PHA02831 143 YPALQNGFLNVF----EKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGIPKCVK 197
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 146-205 2.63e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 55.61  E-value: 2.63e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188    146 CLPVTAPENGKIVSSamepDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
Cdd:smart00032   1 CPPPPDIENGTVTSS----SGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 146-206 1.10e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 1.10e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62739188 146 CLPVTAPENGKIVSSamepDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
Cdd:cd00033   1 CPPPPVPENGTVTGS----KGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTCE 57
Sushi pfam00084
Sushi repeat (SCR repeat);
146-205 1.72e-09

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 53.27  E-value: 1.72e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   146 CLPVTAPENGKIVSsamePDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKC 205
Cdd:pfam00084   1 CPPPPDIPNGKVSA----TKNEYNYGASVSYECDPGYRLVGSPTITCQEDGTWSPPFPEC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 267-444 2.37e-09

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 58.14  E-value: 2.37e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  267 CDNPY-IPNGDYSPLRIKHRTGDEITYQCrNGFYPATRGNTAKC----TSTGWI-PAPRCTLKPC-DYPDIKHGGLYheN 339
Cdd:PHA02639  22 CDKPDdISNGFITELMEKYEIGKLIEYTC-NTDYALIGDRFRTCikdkNNAIWSnKAPFCMLKECnDPPSIINGKIY--N 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  340 MRRPYfpvAVGKYYSYYCDEHFETPSGSYWDH-IHCTQD-GWSPAVPCLR--KCYFPYLENGYNQN--HGRKFVQGKSID 413
Cdd:PHA02639  99 KREMY---KVGDEIYYVCNEHKGVQYSLVGNEkITCIQDkSWKPDPPICKmiNCRFPALQNGYINGipSNKKFYYKTRVG 175

                        170       180       190
                 ....*....|....*....|....*....|..
gi 62739188  414 VACHPGYALPKAQTTVTCMENGWSPT-PRCIR 444
Cdd:PHA02639 176 FSCKSGFDLVGEKYSTCNINATWFPSiPTCVR 207
PHA02639 PHA02639
EEV host range protein; Provisional
 6-206 3.16e-08

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 54.67  E-value: 3.16e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188    6 KIICLMLWAICVAEDCNELPPRRNTEILTGSWSD--QTYPEGTQAIYKCRPGYRSLGNVIMVCRKGE----WVALNPLrk 79
Cdd:PHA02639   2 KIILYLFIGVCYVHGVKSIYCDKPDDISNGFITElmEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKnnaiWSNKAPF-- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   80 CQKRPCGHPGDTPFGTFtLTGGNVFEYGVKAVYTCNE----GYQLLGEINYRECDTDGWTNDIPICEVVKClPVTAPENG 155
Cdd:PHA02639  80 CMLKECNDPPSIINGKI-YNKREMYKVGDEIYYVCNEhkgvQYSLVGNEKITCIQDKSWKPDPPICKMINC-RFPALQNG 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 62739188  156 KIvsSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
Cdd:PHA02639 158 YI--NGIPSNKKFYYKTRVGFSCKSGFDLVGEKYSTCNINATWFPSIPTCV 206
PHA02831 PHA02831
EEV host range protein; Provisional
 226-444 3.84e-08

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 54.23  E-value: 3.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  226 IYKENERFQYKCNMGYEyseRGDAVCTESGWRPLPSCEEK-SCDNPY-IPNGDYSPLRIKHRTGDEITYQCR-NGF--YP 300
Cdd:PHA02831  39 VYEENENLEYKCNNNFD---KVFVTCNNGSWSTKNMCIGKrNCKDPVtILNGYIKNKKDQYSFGDSVTYACKvNKLekYS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  301 ATRGNTAKCTSTGWIPaprctlkpcDYPDIKhgglyhenmrrpyfpvavgkyysyycdehfetpsgsywdhihctqdgws 380
Cdd:PHA02831 116 IVGNETVKCINKQWVP---------KYPVCK------------------------------------------------- 137

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62739188  381 pavpcLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPT-PRCIR 444
Cdd:PHA02831 138 -----LIRCKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPGiPKCVK 197
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 85-142 6.92e-08

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 49.00  E-value: 6.92e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 62739188  85 CGHPGDTPFGTFTLTGGNvFEYGVKAVYTCNEGYQLLGEiNYRECDTDG-WTNDIPICE 142
Cdd:cd00033   1 CPPPPVPENGTVTGSKGS-YSYGSTVTYSCNEGYTLVGS-STITCTENGgWSPPPPTCE 57
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 154-387 1.15e-07

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 53.17  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  154 NGKIVSSamepDREYHFGQAVRFVCNSGYKiEGDEEMHCSDDGfWSKEKPkCVEIsCKSPDVIngSPISQKIIYKENERF 233
Cdd:PHA02954  28 NAKLTST----ETSFNDKQKVTFTCDSGYY-SLDPNAVCETDK-WKYENP-CKKM-CTVSDYV--SELYDKPLYEVNSTI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  234 QYKCNMGYEYSeRGDAVCTESGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGfYPATRGNTAKCTSTG 313
Cdd:PHA02954  98 TLICKDETKYF-RCEEKNGNTSWNDTVTCPNAECQPLQLEHGSCQPVKEKYSFGEHITINCDVG-YEVIGASYISCTANS 175

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62739188  314 WIPAPRCTLKpCDYPDIKHGGLYHENMrrpyfpvAVGKYYSYYCDEHFE---TPSGSywdhihCTQDGWSPAVP-CLR 387
Cdd:PHA02954 176 WNVIPSCQQK-CDIPSLSNGLISGSTF-------SIGGVIHLSCKSGFTltgSPSST------CIDGKWNPVLPiCVR 239
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 85-141 3.07e-07

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 47.14  E-value: 3.07e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 62739188     85 CGHPGDTPFGTFTLTGGNvFEYGVKAVYTCNEGYQLLGEiNYRECDTDG-WTNDIPIC 141
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT-YSYGDTVTYSCDPGYTLIGS-STITCLENGtWSPPPPTC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 141-262 3.88e-07

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 50.71  E-value: 3.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  141 CEVVKCLPVTAPENGKIVSSamepDREYHFGQAVRFVCNSG-----YKIEGDEEMHCSDDGFWSKEKPKCVEISCKSPDV 215
Cdd:PHA02817  19 CDLNKCCYPPSIKNGYIYNK----KTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPAL 94

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 62739188  216 ----INGSPISQKIIYKENERFQykCNMGYEYSERGDAVC-TESGWRP-LPSC 262
Cdd:PHA02817  95 qngfVNGIPDSKKFYYESEVSFS--CKPGFVLIGTKYSVCgINSSWIPkVPIC 145
PHA02817 PHA02817
EEV Host range protein; Provisional
 320-449 8.21e-07

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 49.94  E-value: 8.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  320 CTLKPCDYP-DIKHGGLYheNMRRPYfpvAVGKYYSYYCDEHFETPSGSYW--DHIHCTQDG-WSPAVPCLR--KCYFPY 393
Cdd:PHA02817  19 CDLNKCCYPpSIKNGYIY--NKKTEY---NIGSNVTFFCGNNTRGVRYTLVgeKNIICEKDGkWNKEFPVCKiiRCRFPA 93

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 62739188  394 LENGYNQN--HGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSP-TPRCIRVSFTL 449
Cdd:PHA02817  94 LQNGFVNGipDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPkVPICSRDNITY 152
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 11-206 9.48e-07

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 50.04  E-value: 9.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   11 MLW----AICVAEDCnELPPRRNTEILTGSwsDQTYPEGTQAIYKCRPGYRSLGNVIMVCRKGEWvalnplrkcqkrpcg 86
Cdd:PHA02927 134 MVWnpeaPICESVKC-QSPPSISNGRHNGY--EDFYTDGSVVTYSCNSGYSLIGNSGVLCSGGEW--------------- 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   87 hpgdtpfgtftltggnvfeygvkavytcnegyqllgeinyrecdtdgwtNDIPICEVVKClPVTAPENGKIVSSAmepDR 166
Cdd:PHA02927 196 -------------------------------------------------SDPPTCQIVKC-PHPTISNGYLSSGF---KR 222

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 62739188  167 EYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCV 206
Cdd:PHA02927 223 SYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCV 262
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 109-320 1.62e-06

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 49.70  E-value: 1.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  109 KAVYTCNEGYQLLGEinYRECDTDGWTNDIP---ICEVVKCLpvtapengkivsSAMEPDREYHFGQAVRFVCNSGYKIE 185
Cdd:PHA02954  43 KVTFTCDSGYYSLDP--NAVCETDKWKYENPckkMCTVSDYV------------SELYDKPLYEVNSTITLICKDETKYF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  186 GDEEMHCSDDgfWSkEKPKCVEISCKSPDVINGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESGWRPLPSCEEK 265
Cdd:PHA02954 109 RCEEKNGNTS--WN-DTVTCPNAECQPLQLEHGSCQPVKEKYSFGEHITINCDVGYEVIGASYISCTANSWNVIPSCQQK 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 62739188  266 sCDNPYIPNGDYSPLRIKhrTGDEITYQCRNGFYpATRGNTAKCTSTGWIPA-PRC 320
Cdd:PHA02954 186 -CDIPSLSNGLISGSTFS--IGGVIHLSCKSGFT-LTGSPSSTCIDGKWNPVlPIC 237
PHA02831 PHA02831
EEV host range protein; Provisional
 165-320 8.08e-06

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 47.29  E-value: 8.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  165 DREYHFGQAVRFVCNSGYkiegDEEMHCSDDGFWSKeKPKCV-EISCKSP-DVINGSPISQKIIYKENERFQYKC--NMG 240
Cdd:PHA02831  37 NKVYEENENLEYKCNNNF----DKVFVTCNNGSWST-KNMCIgKRNCKDPvTILNGYIKNKKDQYSFGDSVTYACkvNKL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  241 YEYSERGDAV--CTESGWRP-LPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAKCTSTGWIPA 317
Cdd:PHA02831 112 EKYSIVGNETvkCINKQWVPkYPVCKLIRCKYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSIWYPG 191


                 ....
gi 62739188  318 -PRC 320
Cdd:PHA02831 192 iPKC 195
Sushi pfam00084
Sushi repeat (SCR repeat);
85-141 1.72e-05

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 42.10  E-value: 1.72e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 62739188    85 CGHPGDTPFGTFTlTGGNVFEYGVKAVYTCNEGYQLLGEiNYRECDTDG-WTNDIPIC 141
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDPGYRLVGS-PTITCQEDGtWSPPFPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
 80-207 3.25e-05

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 44.93  E-value: 3.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188   80 CQKRPCGHPGDTPFGtFTLTGGNVFEYGVKAVYTCNEG-----YQLLGEINYrECDTDG-WTNDIPICEVVKClPVTAPE 153
Cdd:PHA02817  19 CDLNKCCYPPSIKNG-YIYNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNI-ICEKDGkWNKEFPVCKIIRC-RFPALQ 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 62739188  154 NGKIvsSAMEPDREYHFGQAVRFVCNSGYKIEGDEEMHCSDDGFWSKEKPKCVE 207
Cdd:PHA02817  96 NGFV--NGIPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSR 147
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 389-443 1.85e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 39.37  E-value: 1.85e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 62739188 389 CYFPY-LENGYNQNHGRKFVQGKSIDVACHPGYALpKAQTTVTCMENG-WSPT-PRCI 443
Cdd:cd00033   1 CPPPPvPENGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTENGgWSPPpPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 267-320 3.41e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.66  E-value: 3.41e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 62739188    267 CDNPY-IPNGDYSPLRIKHRTGDEITYQCRNGFYPaTRGNTAKCTSTG-W-IPAPRC 320
Cdd:smart00032   1 CPPPPdIENGTVTSSSGTYSYGDTVTYSCDPGYTL-IGSSTITCLENGtWsPPPPTC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 210-387 4.85e-04

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 41.96  E-value: 4.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  210 CKSPDVINGSPISQKI-IYKENERFQYKCNMGYEY---------SERGDAVCTESGwrplPSCEEKSC-DNPYIPNGDYS 278
Cdd:PHA02639  22 CDKPDDISNGFITELMeKYEIGKLIEYTCNTDYALigdrfrtciKDKNNAIWSNKA----PFCMLKECnDPPSIINGKIY 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62739188  279 PLRIKHRTGDEITYQC--RNGFYPATRGNTA-KCTS-TGWIP-APRCTLKPCDYPDIKHGGLYH-ENMRRPYFPVAVGky 352
Cdd:PHA02639  98 NKREMYKVGDEIYYVCneHKGVQYSLVGNEKiTCIQdKSWKPdPPICKMINCRFPALQNGYINGiPSNKKFYYKTRVG-- 175

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 62739188  353 ysYYCDEHFETPSGSYWD-HIHCTqdgWSPAVP-CLR 387
Cdd:PHA02639 176 --FSCKSGFDLVGEKYSTcNINAT---WFPSIPtCVR 207
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 392-442 6.86e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.51  E-value: 6.86e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 62739188    392 PYLENGYNQNHGRKFVQGKSIDVACHPGYALpKAQTTVTCMENG-WSPT-PRC 442
Cdd:smart00032   5 PDIENGTVTSSSGTYSYGDTVTYSCDPGYTL-IGSSTITCLENGtWSPPpPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 267-320 9.04e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 37.44  E-value: 9.04e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62739188 267 CDNPYIP-NGDYSPLRIKHRTGDEITYQCRNGFYPaTRGNTAKCTSTG-WIP-APRC 320
Cdd:cd00033   1 CPPPPVPeNGTVTGSKGSYSYGSTVTYSCNEGYTL-VGSSTITCTENGgWSPpPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 210-263 9.31e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 37.44  E-value: 9.31e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 62739188 210 CKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-W-RPLPSCE 263
Cdd:cd00033   1 CPPPPVPeNGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGgWsPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 210-262 3.10e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 35.97  E-value: 3.10e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 62739188    210 CKSPDVI-NGSPISQKIIYKENERFQYKCNMGYEYSERGDAVCTESG-WRP-LPSC 262
Cdd:smart00032   1 CPPPPDIeNGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGtWSPpPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 21-81 4.42e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 35.52  E-value: 4.42e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62739188  21 CNELPPRRNTEILTgswSDQTYPEGTQAIYKCRPGYRSLGNVIMVCRK-GEWValNPLRKCQ 81
Cdd:cd00033   1 CPPPPVPENGTVTG---SKGSYSYGSTVTYSCNEGYTLVGSSTITCTEnGGWS--PPPPTCE 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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