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Conserved domains on  [gi|62530388|ref|NP_001014990|]
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large ribosomal subunit protein uL22m isoform b [Homo sapiens]

Protein Classification

uL22m family ribosomal protein( domain architecture ID 10446401)

uL22m family ribosomal protein is a mitoribosome which binds specifically to rRNA and is important during the early stages of ribosome assembly.

Gene Ontology:  GO:0042255|GO:0003735
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L22 pfam00237
Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and ...
 1-92 2.12e-33

Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.


:

Pssm-ID: 459725  Cd Length: 104  Bit Score: 112.11  E-value: 2.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62530388     1 MWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLKRIRYHGRGRFGI 80
Cdd:pfam00237  13 ARLVADLIRGMSVDEALAILKFSPKKAAKIVLKLLKSAIANAENKGNLD-VDNLYISEIQVDKGPTLKRIRPRARGRAGP 91

                          90
                  ....*....|..
gi 62530388    81 MEKVYCHYFVKL 92
Cdd:pfam00237  92 IRKRTSHITVVL 103
 
Name Accession Description Interval E-value
Ribosomal_L22 pfam00237
Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and ...
 1-92 2.12e-33

Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.


Pssm-ID: 459725  Cd Length: 104  Bit Score: 112.11  E-value: 2.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62530388     1 MWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLKRIRYHGRGRFGI 80
Cdd:pfam00237  13 ARLVADLIRGMSVDEALAILKFSPKKAAKIVLKLLKSAIANAENKGNLD-VDNLYISEIQVDKGPTLKRIRPRARGRAGP 91

                          90
                  ....*....|..
gi 62530388    81 MEKVYCHYFVKL 92
Cdd:pfam00237  92 IRKRTSHITVVL 103
Ribosomal_L22 cd00336
Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal ...
 1-92 5.82e-29

Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper folding and stabilizing the conformation of 23S rRNA. L22 is the largest protein contributor to the surface of the polypeptide exit channel, the tunnel through which the polypeptide product passes. L22 is also one of six proteins located at the putative translocon binding site on the exterior surface of the ribosome.


Pssm-ID: 238205  Cd Length: 105  Bit Score: 101.03  E-value: 5.82e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62530388   1 MWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLKRIRYHGRGRFGI 80
Cdd:cd00336  15 ARLVARLIRGMSVDEALAQLEFVPKKAAKIILKLLKSAEANAENNGLDD-PDKLYIKHIQVNKGPTLKRRRPRARGRANP 93

                        90
                ....*....|..
gi 62530388  81 MEKVYCHYFVKL 92
Cdd:cd00336  94 IRKRTCHITVVL 105
RplV COG0091
Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 ...
 5-94 1.70e-17

Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439861  Cd Length: 110  Bit Score: 72.00  E-value: 1.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62530388   5 AKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLKRIRYHGRGRFGIMEKV 84
Cdd:COG0091  21 ADLIRGKKVEEALAILEFSPKKAARIVLKVLKSAIANAENNNGLD-VDNLVVKEIFVDKGPTLKRFRPRARGRATRIRKR 99

                        90
                ....*....|
gi 62530388  85 YCHYFVKLVE 94
Cdd:COG0091 100 TSHITVVVSE 109
rpl22 CHL00034
ribosomal protein L22
 8-87 2.45e-05

ribosomal protein L22


Pssm-ID: 214342  Cd Length: 117  Bit Score: 40.68  E-value: 2.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62530388    8 IRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAvrDHNVEF-RSNLYIAESTSGRGQCLKRIRYHGRGRFGIMEKVYC 86
Cdd:CHL00034  31 IRGRSYEEALMILEFMPYRACYPILKLVYSAAANA--SHNMGLnKANLFISKAEVDEGPTLKRFRPRAQGRSYPIKKPTC 108


                 .
gi 62530388   87 H 87
Cdd:CHL00034 109 H 109
 
Name Accession Description Interval E-value
Ribosomal_L22 pfam00237
Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and ...
 1-92 2.12e-33

Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.


Pssm-ID: 459725  Cd Length: 104  Bit Score: 112.11  E-value: 2.12e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62530388     1 MWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLKRIRYHGRGRFGI 80
Cdd:pfam00237  13 ARLVADLIRGMSVDEALAILKFSPKKAAKIVLKLLKSAIANAENKGNLD-VDNLYISEIQVDKGPTLKRIRPRARGRAGP 91

                          90
                  ....*....|..
gi 62530388    81 MEKVYCHYFVKL 92
Cdd:pfam00237  92 IRKRTSHITVVL 103
Ribosomal_L22 cd00336
Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal ...
 1-92 5.82e-29

Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper folding and stabilizing the conformation of 23S rRNA. L22 is the largest protein contributor to the surface of the polypeptide exit channel, the tunnel through which the polypeptide product passes. L22 is also one of six proteins located at the putative translocon binding site on the exterior surface of the ribosome.


Pssm-ID: 238205  Cd Length: 105  Bit Score: 101.03  E-value: 5.82e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62530388   1 MWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLKRIRYHGRGRFGI 80
Cdd:cd00336  15 ARLVARLIRGMSVDEALAQLEFVPKKAAKIILKLLKSAEANAENNGLDD-PDKLYIKHIQVNKGPTLKRRRPRARGRANP 93

                        90
                ....*....|..
gi 62530388  81 MEKVYCHYFVKL 92
Cdd:cd00336  94 IRKRTCHITVVL 105
RplV COG0091
Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 ...
 5-94 1.70e-17

Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439861  Cd Length: 110  Bit Score: 72.00  E-value: 1.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62530388   5 AKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLKRIRYHGRGRFGIMEKV 84
Cdd:COG0091  21 ADLIRGKKVEEALAILEFSPKKAARIVLKVLKSAIANAENNNGLD-VDNLVVKEIFVDKGPTLKRFRPRARGRATRIRKR 99

                        90
                ....*....|
gi 62530388  85 YCHYFVKLVE 94
Cdd:COG0091 100 TSHITVVVSE 109
rpl22 CHL00034
ribosomal protein L22
 8-87 2.45e-05

ribosomal protein L22


Pssm-ID: 214342  Cd Length: 117  Bit Score: 40.68  E-value: 2.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62530388    8 IRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAvrDHNVEF-RSNLYIAESTSGRGQCLKRIRYHGRGRFGIMEKVYC 86
Cdd:CHL00034  31 IRGRSYEEALMILEFMPYRACYPILKLVYSAAANA--SHNMGLnKANLFISKAEVDEGPTLKRFRPRAQGRSYPIKKPTC 108


                 .
gi 62530388   87 H 87
Cdd:CHL00034 109 H 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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