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Conserved domains on  [gi|62865612|ref|NP_001015891|]
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adenylate kinase isoenzyme 6 isoform c [Homo sapiens]

Protein Classification

adenylate kinase family protein( domain architecture ID 1904751)

adenylate kinase family protein such as adenylate kinase isoenzyme 6 that has ATPase activity and is a broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0005524|GO:0016887|GO:0050145
SCOP:  4004025

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fap7 super family cl42788
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
7-165 8.97e-39

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


The actual alignment was detected with superfamily member COG1936:

Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 129.94  E-value: 8.97e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDRVVDELDNqMREGGVIVDYHGCDFFP-ERw 85
Cdd:COG1936   7 GTPGTGKTTVAKLLAERLGLEVIHLNDLVKEEGLYTEVDEERDSLVVDEDALAEELEE-LKEGDVIIEGHLAHLVDvDR- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612  86 fhiVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQL-PSNK-PEELennVDQILKWIEQW 163
Cdd:COG1936  85 ---VIVLRCNPEVLEERLEERGYSEEKIRENVEAEALDVILSEAVERFGEEKVYEIdTTGRtPEEV---ADEILAIIKGE 158


                ..
gi 62865612 164 IK 165
Cdd:COG1936 159 RE 160
 
Name Accession Description Interval E-value
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
7-165 8.97e-39

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 129.94  E-value: 8.97e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDRVVDELDNqMREGGVIVDYHGCDFFP-ERw 85
Cdd:COG1936   7 GTPGTGKTTVAKLLAERLGLEVIHLNDLVKEEGLYTEVDEERDSLVVDEDALAEELEE-LKEGDVIIEGHLAHLVDvDR- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612  86 fhiVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQL-PSNK-PEELennVDQILKWIEQW 163
Cdd:COG1936  85 ---VIVLRCNPEVLEERLEERGYSEEKIRENVEAEALDVILSEAVERFGEEKVYEIdTTGRtPEEV---ADEILAIIKGE 158


                ..
gi 62865612 164 IK 165
Cdd:COG1936 159 RE 160
AAA_18 pfam13238
AAA domain;
7-123 1.96e-31

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 109.83  E-value: 1.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612     7 GTPGVGKTTLGKELASKSGLkYINVGDLAREEQLYDGYDEEYD-CPILDED---RVVDEL---DNQMREGGVIVDYHGCD 79
Cdd:pfam13238   5 GTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETReSKRLDEDkldRLLDLLeenAALEEGGNLIIDGHLAE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 62865612    80 FFPERWFHIVFV-LRTDTNVLYERLETRGYNEKKLTDNIQCEIFQ 123
Cdd:pfam13238  84 LEPERAKDLVGIvLRASPEELLERLEKRGYEEAKIKENEEAEILG 128
PRK03839 PRK03839
putative kinase; Provisional
 7-165 5.88e-23

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 89.39  E-value: 5.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612    7 GTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDcpiLDEDRVVDELDNQMREGGVIVDYHGCDFFPErwf 86
Cdd:PRK03839   7 GTPGVGKTTVSKLLAEKLGYEYVDLTEFALKKGIGEEKDDEME---IDFDKLAYFIEEEFKEKNVVLDGHLSHLLPV--- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   87 HIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASyKEEIVHQLPSNK-PEELennVDQILKWIEQWIK 165
Cdd:PRK03839  81 DYVIVLRAHPKIIKERLKERGYSKKKILENVEAELVDVCLCEALEE-KEKVIEVDTTGKtPEEV---VEEILELIKSGKK 156
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 7-107 3.44e-06

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 44.92  E-value: 3.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYINVGDLAREEqlydgydeeydcpILDEDRVVDELDNQMREGGVIVD------------ 74
Cdd:cd01428   6 GPPGSGKGTQAERLAKKYGLPHISTGDLLREE-------------IASGTELGKKAKEYIDSGKLVPDeivikllkerlk 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 62865612  75 ----YHGC--DFFP------ERWFHI---------VFVLRTDTNVLYERLETRG 107
Cdd:cd01428  73 kpdcKKGFilDGFPrtvdqaEALDELldegikpdkVIELDVPDEVLIERILGRR 126
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 7-158 7.70e-03

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 35.42  E-value: 7.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612     7 GTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGydEEYDCPILDEDR---------VVDELDNQMREGGViVDYHG 77
Cdd:TIGR01359   6 GGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREG--SENGSLIESYIKegkivpsevTVELLKKAIQEDGS-SKKFL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612    78 CDFFP------ERWFHI---------VFVLRTDTNVLYERLETRGYNEKKLTDNIQC-----EIFQVLYEEATASYKEE- 136
Cdd:TIGR01359  83 IDGFPrneenlEAWEKLmdnkvnfkfVLFFDCPEETMIKRLLKRGQTSGRVDDNIETlkkrfRTYNEETLPIIEHFENKg 162

                         170       180
                  ....*....|....*....|...
gi 62865612   137 IVHQLPSNKP-EELENNVDQILK 158
Cdd:TIGR01359 163 KVKEINAEGSvEEVFEDVEKIFA 185
 
Name Accession Description Interval E-value
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
7-165 8.97e-39

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 129.94  E-value: 8.97e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDCPILDEDRVVDELDNqMREGGVIVDYHGCDFFP-ERw 85
Cdd:COG1936   7 GTPGTGKTTVAKLLAERLGLEVIHLNDLVKEEGLYTEVDEERDSLVVDEDALAEELEE-LKEGDVIIEGHLAHLVDvDR- 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612  86 fhiVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQL-PSNK-PEELennVDQILKWIEQW 163
Cdd:COG1936  85 ---VIVLRCNPEVLEERLEERGYSEEKIRENVEAEALDVILSEAVERFGEEKVYEIdTTGRtPEEV---ADEILAIIKGE 158


                ..
gi 62865612 164 IK 165
Cdd:COG1936 159 RE 160
AAA_18 pfam13238
AAA domain;
7-123 1.96e-31

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 109.83  E-value: 1.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612     7 GTPGVGKTTLGKELASKSGLkYINVGDLAREEQLYDGYDEEYD-CPILDED---RVVDEL---DNQMREGGVIVDYHGCD 79
Cdd:pfam13238   5 GTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETReSKRLDEDkldRLLDLLeenAALEEGGNLIIDGHLAE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 62865612    80 FFPERWFHIVFV-LRTDTNVLYERLETRGYNEKKLTDNIQCEIFQ 123
Cdd:pfam13238  84 LEPERAKDLVGIvLRASPEELLERLEKRGYEEAKIKENEEAEILG 128
PRK03839 PRK03839
putative kinase; Provisional
 7-165 5.88e-23

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 89.39  E-value: 5.88e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612    7 GTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYDcpiLDEDRVVDELDNQMREGGVIVDYHGCDFFPErwf 86
Cdd:PRK03839   7 GTPGVGKTTVSKLLAEKLGYEYVDLTEFALKKGIGEEKDDEME---IDFDKLAYFIEEEFKEKNVVLDGHLSHLLPV--- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   87 HIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASyKEEIVHQLPSNK-PEELennVDQILKWIEQWIK 165
Cdd:PRK03839  81 DYVIVLRAHPKIIKERLKERGYSKKKILENVEAELVDVCLCEALEE-KEKVIEVDTTGKtPEEV---VEEILELIKSGKK 156
AAA_17 pfam13207
AAA domain;
7-76 5.87e-10

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 54.55  E-value: 5.87e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 62865612     7 GTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGYDEEYD----CPILDEDRVVDELDNQMRE----GGVIVDYH 76
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERGLVEDRDemrkLPLEPQKELQKLAAERIAEeageGGVIVDGH 79
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 7-107 3.44e-06

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 44.92  E-value: 3.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYINVGDLAREEqlydgydeeydcpILDEDRVVDELDNQMREGGVIVD------------ 74
Cdd:cd01428   6 GPPGSGKGTQAERLAKKYGLPHISTGDLLREE-------------IASGTELGKKAKEYIDSGKLVPDeivikllkerlk 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 62865612  75 ----YHGC--DFFP------ERWFHI---------VFVLRTDTNVLYERLETRG 107
Cdd:cd01428  73 kpdcKKGFilDGFPrtvdqaEALDELldegikpdkVIELDVPDEVLIERILGRR 126
PRK04182 PRK04182
cytidylate kinase; Provisional
 7-37 1.62e-05

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 42.87  E-value: 1.62e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 62865612    7 GTPGVGKTTLGKELASKSGLKYINVGDLARE 37
Cdd:PRK04182   7 GPPGSGKTTVARLLAEKLGLKHVSAGEIFRE 37
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 7-135 2.83e-05

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 42.16  E-value: 2.83e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYInvgDLARE-EQ--------LYDGYDEEYDCPIldEDRVVDELDNQmrEGGVIVDYHG 77
Cdd:cd00464   6 GMMGAGKTTVGRLLAKALGLPFV---DLDELiEQragmsipeIFAEEGEEGFREL--EREVLLLLLTK--ENAVIATGGG 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62865612  78 CDFFPE-RWF----HIVFVLRTDTNVLYERL---ETRGynekKLTDNIQCEIFQvLYEEATASYKE 135
Cdd:cd00464  79 AVLREEnRRLllenGIVVWLDASPEELLERLardKTRP----LLQDEDPERLRE-LLEEREPLYRE 139
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
7-107 3.00e-05

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 42.21  E-value: 3.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYINVgDLAReEQLYDGYDEEYDCPILDEDRVVDELDNQMRE---GG--VIVDyHGCDFF 81
Cdd:COG0645   6 GLPGSGKSTLARALAERLGAVRLRS-DVVR-KRLFGAGLAPLERSPEATARTYARLLALAREllaAGrsVILD-ATFLRR 82

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 62865612  82 PER-WF----------HIVFVLRTDTNVLYERLETRG 107
Cdd:COG0645  83 AQReAFralaeeagapFVLIWLDAPEEVLRERLEARN 119
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 7-38 3.50e-05

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 42.48  E-value: 3.50e-05
                         10        20        30
                 ....*....|....*....|....*....|..
gi 62865612    7 GTPGVGKTTLGKELASKSGLKYINVGDLAREE 38
Cdd:PTZ00088  13 GAPGVGKGTFAEILSKKENLKHINMGNILREE 44
SKI pfam01202
Shikimate kinase;
9-161 4.04e-05

Shikimate kinase;


Pssm-ID: 426122 [Multi-domain]  Cd Length: 159  Bit Score: 41.80  E-value: 4.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612     9 PGVGKTTLGKELASKSGLKYINVgDLAREE-------QLYDGYDEEYDCPIldEDRVVDELdnqMREGGVIVDYHGCDF- 80
Cdd:pfam01202   1 MGAGKSTIGRLLAKALGLPFIDT-DEEIEKrtgmsiaEIFEEEGEEGFRRL--ESEVLKEL---LAEHGLVIATGGGAVl 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612    81 FPE-RWF----HIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQLPSNK--PEELennV 153
Cdd:pfam01202  75 SEEnRDLlkerGIVIYLDAPLEVLLERLKRDKTRPLLQNKDPEEELLELLFEERDPLYEEAADIVIDTDEssPEEV---A 151


                  ....*...
gi 62865612   154 DQILKWIE 161
Cdd:pfam01202 152 TEILEALE 159
aroK PRK00131
shikimate kinase; Reviewed
 7-162 8.15e-05

shikimate kinase; Reviewed


Pssm-ID: 234654 [Multi-domain]  Cd Length: 175  Bit Score: 40.94  E-value: 8.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612    7 GTPGVGKTTLGKELASKSGLKYINVgDLAREEQlydgydeeYDCPILD-------------EDRVVDELDNQMRE----- 68
Cdd:PRK00131  11 GFMGAGKSTIGRLLAKRLGYDFIDT-DHLIEAR--------AGKSIPEifeeegeaafrelEEEVLAELLARHNLvistg 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   69 GGVIVDyhgcdffPERW-----FHIVFVLRTDTNVLYERL---ETRG--YNEKKLtdniqcEIFQVLYEEATASYKEEIV 138
Cdd:PRK00131  82 GGAVLR-------EENRallreRGTVVYLDASFEELLRRLrrdRNRPllQTNDPK------EKLRDLYEERDPLYEEVAD 148

                        170       180
                 ....*....|....*....|....*.
gi 62865612  139 HQLPSNK--PEELennVDQILKWIEQ 162
Cdd:PRK00131 149 ITVETDGrsPEEV---VNEILEKLEA 171
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 7-38 1.79e-04

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 40.11  E-value: 1.79e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYINVGDLAREE 38
Cdd:COG0563   7 GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAA 38
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 7-31 2.28e-04

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 39.11  E-value: 2.28e-04
                          10        20
                  ....*....|....*....|....*
gi 62865612     7 GTPGVGKTTLGKELASKSGLKYINV 31
Cdd:pfam00004   5 GPPGTGKTTLAKAVAKELGAPFIEI 29
Kti12 COG4088
tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) ...
 7-164 8.52e-04

tRNA uridine 5-carbamoylmethylation protein Kti12 (Killer toxin insensitivity protein) [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443264 [Multi-domain]  Cd Length: 179  Bit Score: 38.17  E-value: 8.52e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYINVG-----DLAREEQLYDGYDEEYDCPILDedrVVDELDNQMREGG--VIVDyhgcD 79
Cdd:COG4088  11 GPPGSGKTTFAKALAQRLYAEGIAVAllhsdDFRRFLVNESFPKETYEEVVED---VRTTTADNALDNGysVIVD----G 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612  80 FFPERWF-------------HIVFVLRTDTNVLYERLETRGynekkltDNIQCEIFQVLYEEATASYKEEIVHQLPSNKP 146
Cdd:COG4088  84 TFYYRSWqrdfrnlakhkapIHIIYLKAPLETALRRNRERG-------EPIPERVIARMYRKFDKPGTKDRPDLVIDTTE 156

                       170
                ....*....|....*...
gi 62865612 147 EELENNVDQILKWIEQWI 164
Cdd:COG4088 157 DSVSETLDAILKAIETWG 174
AroK COG0703
Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the ...
 9-162 1.64e-03

Shikimate kinase [Amino acid transport and metabolism]; Shikimate kinase is part of the Pathway/BioSystem: Aromatic amino acid biosynthesis


Pssm-ID: 440467 [Multi-domain]  Cd Length: 165  Bit Score: 37.03  E-value: 1.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612   9 PGVGKTTLGKELASKSGLKYInvgDLARE---------EQLYDGYDEEY--DCpildEDRVVDELdNQMRE------GGV 71
Cdd:COG0703   7 MGAGKSTVGRLLAKRLGLPFV---DTDAEieeragmsiPEIFAEEGEAGfrEL----EREVLAEL-LEEENaviatgGGA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612  72 IVDYHGCDFFPERwFHIVFvLRTDTNVLYERL---ETRGynekKLTDNIQCEIFQVLYEEATASYKEEIVHQLPSNK--P 146
Cdd:COG0703  79 VLSPENRELLKEH-GTVVY-LDASPETLLERLrrdDNRP----LLQGEDPRERLEELLAEREPLYREVADITVDTDGrsP 152

                       170
                ....*....|....*.
gi 62865612 147 EELennVDQILKWIEQ 162
Cdd:COG0703 153 EEV---VDEILEALEE 165
PLN02459 PLN02459
probable adenylate kinase
 7-38 1.74e-03

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 37.52  E-value: 1.74e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 62865612    7 GTPGVGKTTLGKELASKSGLKYINVGDLAREE 38
Cdd:PLN02459  36 GCPGVGKGTYASRLSKLLGVPHIATGDLVREE 67
PRK04040 PRK04040
adenylate kinase; Provisional
 7-77 2.27e-03

adenylate kinase; Provisional


Pssm-ID: 235210  Cd Length: 188  Bit Score: 36.79  E-value: 2.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612    7 GTPGVGKTTLGKELASKSGLKY--INVGDLAREEQLYDGYDEEydcpiLDEDRVVDeLDNQMR--------------EGG 70
Cdd:PRK04040   9 GVPGVGKTTVLNKALEKLKEDYkiVNFGDVMLEVAKEEGLVEH-----RDEMRKLP-PEEQKElqreaaeriaemagEGP 82


                 ....*..
gi 62865612   71 VIVDYHG 77
Cdd:PRK04040  83 VIVDTHA 89
Pgk2 COG2074
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
 7-37 6.19e-03

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 441677  Cd Length: 207  Bit Score: 35.69  E-value: 6.19e-03
                        10        20        30
                ....*....|....*....|....*....|.
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYINVGDLARE 37
Cdd:COG2074  13 GASGVGKSTIAAELARRLGIPRVISTDSIRE 43
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 7-158 7.70e-03

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 35.42  E-value: 7.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612     7 GTPGVGKTTLGKELASKSGLKYINVGDLAREEQLYDGydEEYDCPILDEDR---------VVDELDNQMREGGViVDYHG 77
Cdd:TIGR01359   6 GGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKREG--SENGSLIESYIKegkivpsevTVELLKKAIQEDGS-SKKFL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62865612    78 CDFFP------ERWFHI---------VFVLRTDTNVLYERLETRGYNEKKLTDNIQC-----EIFQVLYEEATASYKEE- 136
Cdd:TIGR01359  83 IDGFPrneenlEAWEKLmdnkvnfkfVLFFDCPEETMIKRLLKRGQTSGRVDDNIETlkkrfRTYNEETLPIIEHFENKg 162

                         170       180
                  ....*....|....*....|...
gi 62865612   137 IVHQLPSNKP-EELENNVDQILK 158
Cdd:TIGR01359 163 KVKEINAEGSvEEVFEDVEKIFA 185
GntK cd02021
Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting ...
 7-36 8.23e-03

Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits.


Pssm-ID: 238979 [Multi-domain]  Cd Length: 150  Bit Score: 34.92  E-value: 8.23e-03
                        10        20        30
                ....*....|....*....|....*....|
gi 62865612   7 GTPGVGKTTLGKELASKSGLKYINvGDLAR 36
Cdd:cd02021   6 GVSGSGKSTVGKALAERLGAPFID-GDDLH 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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