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Conserved domains on  [gi|226530702|ref|NP_001017866|]
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FAU ubiquitin like and ribosomal protein S30 fusion b [Danio rerio]

Protein Classification

eS30 family ribosomal protein( domain architecture ID 10110365)

eS30 family ribosomal protein is synthesized as a C-terminal extension protein (CEP) of a ubiquitin-like protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ubl_FUBI cd01793
ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins; FUBI is ...
 1-74 1.87e-37

ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins; FUBI is a pro-apoptotic regulatory gene FAU encoding ubiquitin-like protein with ribosomal protein S30 as a C-terminal extension. FUBI functions as a tumor suppressor protein that may be involved in the ATP-dependent proteolytic activity of ubiquitin. The N-terminal ubiquitin-like (Ubl) domain of FUBI has the beta-grasp Ubl fold, and it may act as a substitute or an inhibitor of ubiquitin or one of ubiquitin's close relatives UCRP, FAT10, and Nedd8.


:

Pssm-ID: 340491  Cd Length: 74  Bit Score: 122.01  E-value: 1.87e-37
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226530702   1 MQLFVRGQSLHSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTLEVSSRLLGG 74
Cdd:cd01793    1 MQLFVRAQSLHTLEVSGNETVADIKAHIAALEGIAVEDQVLLYAGAPLEDDVVLGQCGIPDLATLEVAVRLLGG 74
Ribosomal_S30 pfam04758
Ribosomal protein S30;
75-132 3.33e-35

Ribosomal protein S30;


:

Pssm-ID: 398432  Cd Length: 58  Bit Score: 115.83  E-value: 3.33e-35
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 226530702   75 KVHGSLARAGKVRGQTPKVDKQEKRKKRTGRAKRRIQYNRRFVNVVPTFGKKKGPNAN 132
Cdd:pfam04758   1 KVHGSLARAGKVRNQTPKVEKQEKKKKPTGRAKKRLQYNRRFVNVVPGGGRKKGPNSQ 58
 
Name Accession Description Interval E-value
Ubl_FUBI cd01793
ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins; FUBI is ...
 1-74 1.87e-37

ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins; FUBI is a pro-apoptotic regulatory gene FAU encoding ubiquitin-like protein with ribosomal protein S30 as a C-terminal extension. FUBI functions as a tumor suppressor protein that may be involved in the ATP-dependent proteolytic activity of ubiquitin. The N-terminal ubiquitin-like (Ubl) domain of FUBI has the beta-grasp Ubl fold, and it may act as a substitute or an inhibitor of ubiquitin or one of ubiquitin's close relatives UCRP, FAT10, and Nedd8.


Pssm-ID: 340491  Cd Length: 74  Bit Score: 122.01  E-value: 1.87e-37
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226530702   1 MQLFVRGQSLHSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTLEVSSRLLGG 74
Cdd:cd01793    1 MQLFVRAQSLHTLEVSGNETVADIKAHIAALEGIAVEDQVLLYAGAPLEDDVVLGQCGIPDLATLEVAVRLLGG 74
Ribosomal_S30 pfam04758
Ribosomal protein S30;
75-132 3.33e-35

Ribosomal protein S30;


Pssm-ID: 398432  Cd Length: 58  Bit Score: 115.83  E-value: 3.33e-35
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 226530702   75 KVHGSLARAGKVRGQTPKVDKQEKRKKRTGRAKRRIQYNRRFVNVVPTFGKKKGPNAN 132
Cdd:pfam04758   1 KVHGSLARAGKVRNQTPKVEKQEKKKKPTGRAKKRLQYNRRFVNVVPGGGRKKGPNSQ 58
PTZ00467 PTZ00467
40S ribosomal protein S30; Provisional
 74-117 7.82e-14

40S ribosomal protein S30; Provisional


Pssm-ID: 185646  Cd Length: 66  Bit Score: 61.71  E-value: 7.82e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 226530702  74 GKVHGSLARAGKVRGQTPKVDKQEKRKKRTGRAKRRIQYNRRFV 117
Cdd:PTZ00467   2 GKIHGSLARAGKVKNQTPKVAKQEKPKQPRGRALKRLKYTRRFL 45
RPS30 COG4919
Ribosomal protein S30 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S30 ...
 77-117 1.52e-09

Ribosomal protein S30 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S30 is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 443947  Cd Length: 52  Bit Score: 50.39  E-value: 1.52e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 226530702  77 HGSLARAGKVRGQTPKVDKQEKRKKrTGRAKRRIQYNRRFV 117
Cdd:COG4919    4 HGSLTKAGKVRSQTPKIPAKPRKNP-PPRVRNRREYRKRFV 43
UBQ smart00213
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ...
 1-67 4.32e-09

Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression


Pssm-ID: 214563 [Multi-domain]  Cd Length: 72  Bit Score: 49.56  E-value: 4.32e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226530702     1 MQLFVR--GQSLHSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTLEV 67
Cdd:smart00213   1 IELTVKtlDGKTITLEVKPSDTVSELKEKIAELTGIPPEQQRLIYKGKVLEDDRTLADYGIQDGSTIHL 69
ubiquitin pfam00240
Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog) ...
 3-71 6.25e-09

Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog), Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.


Pssm-ID: 459726 [Multi-domain]  Cd Length: 72  Bit Score: 49.09  E-value: 6.25e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226530702    3 LFVR--GQSLHSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTLEVSSRL 71
Cdd:pfam00240   1 ITVKtlDGKKITLEVDPTDTVLELKEKIAEKEGVPPEQQRLIYSGKVLEDDQTLGEYGIEDGSTIHLVLRQ 71
 
Name Accession Description Interval E-value
Ubl_FUBI cd01793
ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins; FUBI is ...
 1-74 1.87e-37

ubiquitin-like (Ubl) domain found in ubiquitin-like protein FUBI and similar proteins; FUBI is a pro-apoptotic regulatory gene FAU encoding ubiquitin-like protein with ribosomal protein S30 as a C-terminal extension. FUBI functions as a tumor suppressor protein that may be involved in the ATP-dependent proteolytic activity of ubiquitin. The N-terminal ubiquitin-like (Ubl) domain of FUBI has the beta-grasp Ubl fold, and it may act as a substitute or an inhibitor of ubiquitin or one of ubiquitin's close relatives UCRP, FAT10, and Nedd8.


Pssm-ID: 340491  Cd Length: 74  Bit Score: 122.01  E-value: 1.87e-37
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226530702   1 MQLFVRGQSLHSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTLEVSSRLLGG 74
Cdd:cd01793    1 MQLFVRAQSLHTLEVSGNETVADIKAHIAALEGIAVEDQVLLYAGAPLEDDVVLGQCGIPDLATLEVAVRLLGG 74
Ribosomal_S30 pfam04758
Ribosomal protein S30;
75-132 3.33e-35

Ribosomal protein S30;


Pssm-ID: 398432  Cd Length: 58  Bit Score: 115.83  E-value: 3.33e-35
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 226530702   75 KVHGSLARAGKVRGQTPKVDKQEKRKKRTGRAKRRIQYNRRFVNVVPTFGKKKGPNAN 132
Cdd:pfam04758   1 KVHGSLARAGKVRNQTPKVEKQEKKKKPTGRAKKRLQYNRRFVNVVPGGGRKKGPNSQ 58
PTZ00467 PTZ00467
40S ribosomal protein S30; Provisional
 74-117 7.82e-14

40S ribosomal protein S30; Provisional


Pssm-ID: 185646  Cd Length: 66  Bit Score: 61.71  E-value: 7.82e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 226530702  74 GKVHGSLARAGKVRGQTPKVDKQEKRKKRTGRAKRRIQYNRRFV 117
Cdd:PTZ00467   2 GKIHGSLARAGKVKNQTPKVAKQEKPKQPRGRALKRLKYTRRFL 45
PRK09336 PRK09336
30S ribosomal protein S30e; Provisional
 77-119 9.00e-10

30S ribosomal protein S30e; Provisional


Pssm-ID: 181786  Cd Length: 50  Bit Score: 50.94  E-value: 9.00e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 226530702  77 HGSLARAGKVRGQTPKVDKQEKRKKrTGRAKRRIQYNRRFVNV 119
Cdd:PRK09336   4 HGSLTKAGKVRSQTPKIPPKPKKNE-VPRVRNRREYERRVLKA 45
RPS30 COG4919
Ribosomal protein S30 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S30 ...
 77-117 1.52e-09

Ribosomal protein S30 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S30 is part of the Pathway/BioSystem: Archaeal ribosomal proteins


Pssm-ID: 443947  Cd Length: 52  Bit Score: 50.39  E-value: 1.52e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 226530702  77 HGSLARAGKVRGQTPKVDKQEKRKKrTGRAKRRIQYNRRFV 117
Cdd:COG4919    4 HGSLTKAGKVRSQTPKIPAKPRKNP-PPRVRNRREYRKRFV 43
UBQ smart00213
Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of ...
 1-67 4.32e-09

Ubiquitin homologues; Ubiquitin-mediated proteolysis is involved in the regulated turnover of proteins required for controlling cell cycle progression


Pssm-ID: 214563 [Multi-domain]  Cd Length: 72  Bit Score: 49.56  E-value: 4.32e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226530702     1 MQLFVR--GQSLHSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTLEV 67
Cdd:smart00213   1 IELTVKtlDGKTITLEVKPSDTVSELKEKIAELTGIPPEQQRLIYKGKVLEDDRTLADYGIQDGSTIHL 69
ubiquitin pfam00240
Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog) ...
 3-71 6.25e-09

Ubiquitin family; This family contains a number of ubiquitin-like proteins: SUMO (smt3 homolog), Nedd8, Elongin B, Rub1, and Parkin. A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites.


Pssm-ID: 459726 [Multi-domain]  Cd Length: 72  Bit Score: 49.09  E-value: 6.25e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 226530702    3 LFVR--GQSLHSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTLEVSSRL 71
Cdd:pfam00240   1 ITVKtlDGKKITLEVDPTDTVLELKEKIAEKEGVPPEQQRLIYSGKVLEDDQTLGEYGIEDGSTIHLVLRQ 71
Ubl_ubiquitin_like cd17039
ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like ...
 11-67 2.00e-08

ubiquitin-like (Ubl) domain found in ubiquitin and ubiquitin-like Ubl proteins; Ubiquitin-like (Ubl) proteins have a similar ubiquitin (Ub) beta-grasp fold and attach to other proteins in a Ubl manner but with biochemically distinct roles. Ub and Ubl proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some Ubl domains have adaptor roles in Ub-signaling by mediating protein-protein interaction. Prokaryotic sulfur carrier proteins are Ub-related proteins that can be activated in an ATP-dependent manner. Polyubiquitination signals for a diverse set of cellular events via different isopeptide linkages formed between the C terminus of one ubiquitin (Ub) and the epsilon-amine of K6, K11, K27, K29, K33, K48, or K63 of a second Ub. One of these seven lysine residues (K27, Ub numbering) is conserved in this Ubl_ubiquitin_like family. K27-linked Ub chains are versatile and can be recognized by several downstream receptor proteins. K27 has roles beyond chain linkage, such as in Ubl NEDD8 (which contains many of the same lysines (K6, K11, K27, K33, K48) as Ub) where K27 has a role (other than conjugation) in the mechanism of protein neddylation.


Pssm-ID: 340559 [Multi-domain]  Cd Length: 68  Bit Score: 47.59  E-value: 2.00e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 226530702  11 HSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTLEV 67
Cdd:cd17039   11 YTVEVDPDDTVADLKEKIEEKTGIPVEQQRLIYNGKELKDDKTLSDYGIKDGSTIHL 67
Ubl2_ISG15 cd01810
ubiquitin-like (Ubl) domain 2 found in interferon-stimulated gene 15 (ISG15) and similar ...
 1-71 2.91e-08

ubiquitin-like (Ubl) domain 2 found in interferon-stimulated gene 15 (ISG15) and similar proteins; ISG15, also termed interferon-induced 15 kDa protein, or interferon-induced 17 kDa protein (IP17), or ubiquitin cross-reactive protein (UCRP), is an antiviral interferon-induced ubiquitin-like protein that upon viral infection it modifies cellular and viral proteins by mechanisms similar to ubiquitination. Although ISG15 has properties similar to those of other ubiquitin-like (Ubl) molecules, it is a unique member of the Ubl superfamily, whose expression and conjugation to target proteins are tightly regulated by specific signaling pathways, indicating it may have specialized functions in the immune system. ISG15 contains two tandem Ubl domains with a beta-grasp Ubl fold. This family corresponds to the second Ubl domain.


Pssm-ID: 340508 [Multi-domain]  Cd Length: 74  Bit Score: 47.45  E-value: 2.91e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 226530702   1 MQLFVR---GQSlHSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTLEVSSRL 71
Cdd:cd01810    1 LSIFVRnekGQS-HTYEVRLTQTVDQLKQKVSGREGVHDDQFWLTFEGRPLEDQLPLGEYGLKPQSTIHMNLRL 73
Ubl2_OASL cd16103
ubiquitin-like (Ubl) domain 2 found in 2'-5'-oligoadenylate synthase-like protein (OASL) and ...
 2-68 6.19e-05

ubiquitin-like (Ubl) domain 2 found in 2'-5'-oligoadenylate synthase-like protein (OASL) and similar proteins; OASL, also termed 2'-5'-OAS-related protein (2'-5'-OAS-RP), or 59 kDa 2'-5'-oligoadenylate synthase-like protein, or thyroid receptor-interacting protein 14, or TR-interacting protein 14 (TRIP-14), or p59 OASL (p59OASL), is an interferon (IFN)-induced antiviral protein that plays an important role in the IFNs-mediated antiviral signaling pathway. It inhibits respiratory syncytial virus replication and is targeted by the viral nonstructural protein 1 (NS1). It also displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. Moreover, OASL does not have 2'-5'-OAS activity, but can bind double-stranded RNA (dsRNA) to enhance RIG-I signaling. OASL belongs to the 2'-5' oligoadenylate synthase (OAS) family. While each member of this family has a conserved N-terminal OAS catalytic domain, only OASL has two tandem C-terminal ubiquitin-like (Ubl) repeats, which are required for its antiviral activity. This family corresponds to the second Ubl domain.


Pssm-ID: 340520 [Multi-domain]  Cd Length: 72  Bit Score: 38.81  E-value: 6.19e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 226530702   2 QLFVR--GQSLHSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTLEVS 68
Cdd:cd16103    3 QIFVKfpDGTSKPYAINPEDTILDLKEKIEEQGGPPVEDQILLFQGQELRDKKSLKYYGIKDGDTLQLS 71
Ubl2_FAT10 cd17053
ubiquitin-like (Ubl) domain 2 found in leukocyte antigen F (HLA-F) adjacent transcript 10 ...
 11-67 6.56e-05

ubiquitin-like (Ubl) domain 2 found in leukocyte antigen F (HLA-F) adjacent transcript 10 (FAT10) and similar proteins; FAT10, also termed ubiquitin D (UBD), or diubiquitin, is a cytokine-inducible ubiquitin-like (Ubl) modifer that is highly expressed in the thymus, and targets substrates covalently for 26S proteasomal degradation. It is also associated with cancer development, antigen processing and antimicrobial defense, chromosomal stability and cell cycle regulation. FAT10 is presented on immune cells and under the inflammatory conditions, is synergistically induced by interferon gamma (IFNgamma) and tumor necrosis factor (TNFalpha) in the non-immune (liver parenchymal) cells. FAT10 contains two Ubl domains. The family corresponds to the second Ubl domain of FAT10. Some family members contain only one Ubl domain.


Pssm-ID: 340573  Cd Length: 71  Bit Score: 38.48  E-value: 6.56e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 226530702  11 HSVQLNGSETVAHIKAQIEALEGLACDDQIISLSGIPLED-DALICQSGIEEFNTLEV 67
Cdd:cd17053   13 HTLQVSRSTTVAQVKAMIEDQSGVPPNEQILVYNGKRLEDgDKTLGEYGIKTGDTLYL 70
Ubl_ZFAND4 cd01802
ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar ...
 1-65 1.67e-04

ubiquitin-like (Ubl) domain found in AN1-type zinc finger protein 4 (ZFAND4) and similar proteins; ZFAND4, also termed AN1-type zinc finger and ubiquitin domain-containing protein-like 1 (ANUBL1), may function as an oncogene that promotes proliferation and regulates relevant tumor suppressor genes in gastric cancer, suggesting a role in gastric cancer initiation and progression. ZFAND4contains an N-terminal ubiquitin-like (Ubl) domain with a beta-grasp Ubl fold, a common structure involved in protein-protein interactions, as well as a C-terminal AN1-type zinc finger. Unlike ubiquitin polyproteins and most ubiquitin fusion proteins, the N-terminal Ubl domain of ZFAND4 does not undergo proteolytic processing.


Pssm-ID: 340500 [Multi-domain]  Cd Length: 74  Bit Score: 37.69  E-value: 1.67e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 226530702   1 MQLFVRGQSLHSVQLNGS--ETVAHIKAQIEALEGLACDDQIISLSGIPLEDDALICQSGIEEFNTL 65
Cdd:cd01802    1 MELFIETLTGTAFELRVSpfETVASVKAKIQRLEGIPVSQQHLIWSGRELEDDYCLHDYNITDGSTL 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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