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Conserved domains on  [gi|63079683|ref|NP_001017926|]
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zinc fingers and homeoboxes protein 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 98-150 3.80e-23

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


:

Pssm-ID: 465737  Cd Length: 53  Bit Score: 92.78  E-value: 3.80e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 63079683    98 LNSSYVCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTIND 150
Cdd:pfam18387   1 ADPSFVCVECGFSAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLVD 53
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 468-523 6.26e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 58.41  E-value: 6.26e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 63079683 468 RAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRNSK 523
Cdd:cd00086   4 RTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 665-716 1.15e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 57.65  E-value: 1.15e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 63079683    665 CKKTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWK 716
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homez super family cl13082
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 785-821 2.84e-07

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


The actual alignment was detected with superfamily member pfam11569:

Pssm-ID: 463297  Cd Length: 57  Bit Score: 48.07  E-value: 2.84e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 63079683   785 LKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAER 821
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 299-343 1.43e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 46.08  E-value: 1.43e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 63079683 299 LLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKHGVSW 343
Cdd:cd00086  15 LEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 576-621 3.71e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 44.93  E-value: 3.71e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 63079683    576 TAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKKK 621
Cdd:smart00389   9 TPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRA 54
 
Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 98-150 3.80e-23

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


Pssm-ID: 465737  Cd Length: 53  Bit Score: 92.78  E-value: 3.80e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 63079683    98 LNSSYVCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTIND 150
Cdd:pfam18387   1 ADPSFVCVECGFSAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLVD 53
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 468-523 6.26e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 58.41  E-value: 6.26e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 63079683 468 RAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRNSK 523
Cdd:cd00086   4 RTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 665-716 1.15e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 57.65  E-value: 1.15e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 63079683    665 CKKTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWK 716
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 665-717 2.21e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 56.87  E-value: 2.21e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 63079683 665 CKKTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWKN 717
Cdd:cd00086   5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 468-520 2.91e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 56.49  E-value: 2.91e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 63079683    468 RAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQR 520
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 785-821 2.84e-07

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


Pssm-ID: 463297  Cd Length: 57  Bit Score: 48.07  E-value: 2.84e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 63079683   785 LKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAER 821
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 299-343 1.43e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 46.08  E-value: 1.43e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 63079683 299 LLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKHGVSW 343
Cdd:cd00086  15 LEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 297-339 2.51e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 45.32  E-value: 2.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 63079683    297 PLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKH 339
Cdd:smart00389  14 EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 576-621 3.71e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 44.93  E-value: 3.71e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 63079683    576 TAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKKK 621
Cdd:smart00389   9 TPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRA 54
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 575-616 8.04e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 43.77  E-value: 8.04e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 63079683 575 KTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWF 616
Cdd:cd00086   7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWF 48
Homeodomain pfam00046
Homeodomain;
668-717 1.18e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 43.26  E-value: 1.18e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 63079683   668 TPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWKN 717
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 782-825 4.95e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 41.85  E-value: 4.95e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 63079683 782 TAILKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAERQRRS 825
Cdd:cd00086  12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKL 55
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 782-825 5.16e-05

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 41.47  E-value: 5.16e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 63079683    782 TAILKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAERQRRS 825
Cdd:smart00389  13 LEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
Homeodomain pfam00046
Homeodomain;
299-339 1.77e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 40.18  E-value: 1.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 63079683   299 LLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKH 339
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
Homeodomain pfam00046
Homeodomain;
472-521 3.08e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 39.41  E-value: 3.08e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 63079683   472 TKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRN 521
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
576-616 1.83e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 37.09  E-value: 1.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 63079683   576 TAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWF 616
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF 48
 
Name Accession Description Interval E-value
zf_C2H2_ZHX pfam18387
Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX ...
 98-150 3.80e-23

Zinc-fingers and homeoboxes C2H2 finger domain; This is a C2H2 zinc-finger domain found in ZHX proteins such as ZHX1. ZHXs are multidomain proteins comprising two C2H2 zinc finger motifs and five homeodomains. Both homeodomains and zinc fingers are short protein modules involved in protein-DNA and/or protein-protein interactions; they are frequently associated with roles in transcriptional regulation. All members of the ZHX family are reported to be able to form both homo- and heterodimers via the region containing homeodomain 1. ZHX1 is a transcriptional repressor which is ubiquitously expressed. It interacts with nuclear factor Y subunit A (NFYA) and DNA methyl transferase 3B (DNMT3B) for its repression activity. Changes in expression profiles of rat ZHX1 ortholog have been associated with glomerular disease. In addition to the five homeodomains, ZHX1, which also contains of two N terminal C2H2 zincfingers forms homodimers via homeodomain and can also form heterodimers with ZHX3.


Pssm-ID: 465737  Cd Length: 53  Bit Score: 92.78  E-value: 3.80e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 63079683    98 LNSSYVCVECNFLTKRYDALSEHNLKYHPGEENFKLTMVKRNNQTIFEQTIND 150
Cdd:pfam18387   1 ADPSFVCVECGFSAKKFEGLALHNAESHPGETNFTLQVVKRDNQTTVEQSLVD 53
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 468-523 6.26e-11

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 58.41  E-value: 6.26e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 63079683 468 RAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRNSK 523
Cdd:cd00086   4 RTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 665-716 1.15e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 57.65  E-value: 1.15e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 63079683    665 CKKTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWK 716
Cdd:smart00389   6 TSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 665-717 2.21e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 56.87  E-value: 2.21e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 63079683 665 CKKTPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWKN 717
Cdd:cd00086   5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 468-520 2.91e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 56.49  E-value: 2.91e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 63079683    468 RAKKTKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQR 520
Cdd:smart00389   5 RTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
Homez pfam11569
Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and ...
 785-821 2.84e-07

Homeodomain leucine-zipper encoding, Homez; Homez contains two leucine zipper-like motifs and an acidic domain and belongs to the superfamily of homeobox-containing proteins. The presence of leucine zippers suggests that Homez can function as a homo or heterodimer in the nucleus. It is thought that the first leucine zipper and homeodomain 1 (HD1)of Homez is responsible for dimerization and HD2 has a specific DNA-binding activity. Homez is also thought to function as a transcriptional repressor due to the acidic region in its C-terminal domain. Homez is involved in a complex regulatory network.


Pssm-ID: 463297  Cd Length: 57  Bit Score: 48.07  E-value: 2.84e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 63079683   785 LKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAER 821
Cdd:pfam11569  14 LEKYWAATGQLQEKDLDKLCQKSKMSYQQVRDWFASR 50
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 299-343 1.43e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 46.08  E-value: 1.43e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 63079683 299 LLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKHGVSW 343
Cdd:cd00086  15 LEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 297-339 2.51e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 45.32  E-value: 2.51e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 63079683    297 PLLLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKH 339
Cdd:smart00389  14 EELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 576-621 3.71e-06

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 44.93  E-value: 3.71e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 63079683    576 TAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWFTEKKK 621
Cdd:smart00389   9 TPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRA 54
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 575-616 8.04e-06

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 43.77  E-value: 8.04e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 63079683 575 KTAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWF 616
Cdd:cd00086   7 FTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWF 48
Homeodomain pfam00046
Homeodomain;
668-717 1.18e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 43.26  E-value: 1.18e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 63079683   668 TPEQLHMLKSAFVRTQWPSPEEYDKLAKESGLARTDIVSWFGDTRYAWKN 717
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 782-825 4.95e-05

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 41.85  E-value: 4.95e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 63079683 782 TAILKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAERQRRS 825
Cdd:cd00086  12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKL 55
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 782-825 5.16e-05

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 41.47  E-value: 5.16e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 63079683    782 TAILKDYYLKHKFLNEQDLDELVNKSHMGYEQVREWFAERQRRS 825
Cdd:smart00389  13 LEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
Homeodomain pfam00046
Homeodomain;
299-339 1.77e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 40.18  E-value: 1.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 63079683   299 LLNTYNKFPYPTMSEITVLSAQAKYTEEQIKIWFSAQRLKH 339
Cdd:pfam00046  15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKW 55
Homeodomain pfam00046
Homeodomain;
472-521 3.08e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 39.41  E-value: 3.08e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 63079683   472 TKEQLAELKVSYLKNQFPHDSEIIRLMKITGLTKGEIKKWFSDTRYNQRN 521
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
576-616 1.83e-03

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 37.09  E-value: 1.83e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 63079683   576 TAEQLRVLQASFLNSSVLTDEELNRLRAQTKLTRREIDAWF 616
Cdd:pfam00046   8 TPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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