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Conserved domains on  [gi|120953245|ref|NP_001020022|]
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ankyrin repeat domain-containing protein 34A [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-133 1.14e-25

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.58  E-value: 1.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDpqnkarMVRYLLEQGADPNIADRLGRTALMHACAG 87
Cdd:COG0666   90 LLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE------IVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 120953245  88 GGGAAVAsLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDA 133
Cdd:COG0666  164 GNLEIVK-LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-133 1.14e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.58  E-value: 1.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDpqnkarMVRYLLEQGADPNIADRLGRTALMHACAG 87
Cdd:COG0666   90 LLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE------IVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 120953245  88 GGGAAVAsLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDA 133
Cdd:COG0666  164 GNLEIVK-LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
Ank_2 pfam12796
Ankyrin repeats (3 copies);
9-108 1.99e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.83  E-value: 1.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245    9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDpqnkarMVRYLLEQgADPNIADRlGRTALMHACAGG 88
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE------IVKLLLEH-ADVNLKDN-GRTALHYAARSG 72

                          90       100
                  ....*....|....*....|
gi 120953245   89 GGAAVAsLLLAHGADPSVRD 108
Cdd:pfam12796  73 HLEIVK-LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 7-133 5.74e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 5.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   7 HALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMaaCRARYDdpqNKARMVRYLLEQGADPNIADRLGRTAL-MHAC 85
Cdd:PHA03095  52 HLYLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLH--LYLYNA---TTLDVIKLLIKAGADVNAKDKVGRTPLhVYLS 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 120953245  86 AGGGGAAVASLLLAHGADPSVRDHAGASALvHALDRGDR---ETLATLLDA 133
Cdd:PHA03095 127 GFNINPKVIRLLLRKGADVNALDLYGMTPL-AVLLKSRNanvELLRLLIDA 176
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 37-72 9.10e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.72  E-value: 9.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 120953245    37 QGETALMAACRARYDDpqnkarMVRYLLEQGADPNI 72
Cdd:smart00248   1 DGRTPLHLAAENGNLE------VVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-133 1.14e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 106.58  E-value: 1.14e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDpqnkarMVRYLLEQGADPNIADRLGRTALMHACAG 87
Cdd:COG0666   90 LLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE------IVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 120953245  88 GGGAAVAsLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDA 133
Cdd:COG0666  164 GNLEIVK-LLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-147 3.40e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 3.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRaryddpQNKARMVRYLLEQGADPNIADRLGRTALMHACAG 87
Cdd:COG0666  156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE------NGHLEIVKLLLEAGADVNAKDNDGKTALDLAAEN 229

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245  88 GGGAAVAsLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDACKAKGTEVIIITTD 147
Cdd:COG0666  230 GNLEIVK-LLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
9-108 1.99e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.83  E-value: 1.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245    9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDpqnkarMVRYLLEQgADPNIADRlGRTALMHACAGG 88
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLE------IVKLLLEH-ADVNLKDN-GRTALHYAARSG 72

                          90       100
                  ....*....|....*....|
gi 120953245   89 GGAAVAsLLLAHGADPSVRD 108
Cdd:pfam12796  73 HLEIVK-LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 7-133 5.74e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 5.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   7 HALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMaaCRARYDdpqNKARMVRYLLEQGADPNIADRLGRTAL-MHAC 85
Cdd:PHA03095  52 HLYLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLH--LYLYNA---TTLDVIKLLIKAGADVNAKDKVGRTPLhVYLS 126

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 120953245  86 AGGGGAAVASLLLAHGADPSVRDHAGASALvHALDRGDR---ETLATLLDA 133
Cdd:PHA03095 127 GFNINPKVIRLLLRKGADVNALDLYGMTPL-AVLLKSRNanvELLRLLIDA 176
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
7-133 8.89e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 8.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   7 HALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRAryddpqNKARMVRYLLEQGADPNIADRLGRTALMHACA 86
Cdd:COG0666   23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALA------GDLLVALLLLAAGADINAKDDGGNTLLHAAAR 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 120953245  87 GGGGAAVAsLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDA 133
Cdd:COG0666   97 NGDLEIVK-LLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
PHA03095 PHA03095
ankyrin-like protein; Provisional
 17-145 7.02e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.56  E-value: 7.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245  17 KLRLARLLLEGGAYVNEGDAQGETALMAACRAryddPQNKARMVRYLLEQGADPNIADRLGRTAL-MHACAGGGGAAVAS 95
Cdd:PHA03095  96 TLDVIKLLIKAGADVNAKDKVGRTPLHVYLSG----FNINPKVIRLLLRKGADVNALDLYGMTPLaVLLKSRNANVELLR 171

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 120953245  96 LLLAHGADPSVRDHAGASAL-VHALDRGDRET-LATLLDA-CKAKGTEVIIIT 145
Cdd:PHA03095 172 LLIDAGADVYAVDDRFRSLLhHHLQSFKPRARiVRELIRAgCDPAATDMLGNT 224
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 19-132 2.27e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.06  E-value: 2.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245  19 RLARLLLEGGAYVNEGDAQGETALMAACRARYDDPQnkarmVRYLLEQGADPNIADRLGRTALMHACAGGGGAAVASLLL 98
Cdd:PHA02876 288 RLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTEN-----IRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLL 362

                         90       100       110
                 ....*....|....*....|....*....|....
gi 120953245  99 AHGADPSVRDHAGASALVHALDRGDRETLATLLD 132
Cdd:PHA02876 363 ELGANVNARDYCDKTPIHYAAVRNNVVIINTLLD 396
Ank_2 pfam12796
Ankyrin repeats (3 copies);
42-132 2.69e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.49  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   42 LMAACRaryddpQNKARMVRYLLEQGADPNIADRLGRTALMHaCAGGGGAAVASLLLAHgADPSVRDHaGASALVHALDR 121
Cdd:pfam12796   1 LHLAAK------NGNLELVKLLLENGADANLQDKNGRTALHL-AAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARS 71

                          90
                  ....*....|.
gi 120953245  122 GDRETLATLLD 132
Cdd:pfam12796  72 GHLEIVKLLLE 82
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-133 3.05e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.60  E-value: 3.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   9 LLRAVGQGKLRLARLLLEGGAYVNEG-DAQGETALMAACRARyddpqnKARMVRYLLEQGADPNIADRlGRTALMHACAG 87
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPLHLATILK------KLDIMKLLIARGADPDIPNT-DKFSPLHLAVM 144

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 120953245  88 GGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDA 133
Cdd:PHA02875 145 MGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-118 4.55e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.87  E-value: 4.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   3 HTEGHALLRAVGqGKLRLARLLLEGGAYVNEGDAQGETAL---MAACRARyddpqnkARMVRYLLEQGADPNIADRLGRT 79
Cdd:PHA03095 153 MTPLAVLLKSRN-ANVELLRLLIDAGADVYAVDDRFRSLLhhhLQSFKPR-------ARIVRELIRAGCDPAATDMLGNT 224

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 120953245  80 ALmHACAGGGGAAVASL--LLAHGADPSVRDHAGASALVHA 118
Cdd:PHA03095 225 PL-HSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYA 264
Ank_5 pfam13857
Ankyrin repeats (many copies);
23-81 1.04e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.72  E-value: 1.04e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 120953245   23 LLLEGGAYVNEGDAQGETALMAACRaryddpQNKARMVRYLLEQGADPNIADRLGRTAL 81
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAK------YGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 37-75 1.43e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.89  E-value: 1.43e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 120953245   37 QGETALMAACRARyddpqNKARMVRYLLEQGADPNIADR 75
Cdd:pfam00023   1 DGNTPLHLAAGRR-----GNLEIVKLLLSKGADVNARDK 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 23-81 6.92e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.04  E-value: 6.92e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 120953245  23 LLLEGGAYVNEGDAQGETALMAACRARYDDpqnkarMVRYLLEQGADPNIADRLGRTAL 81
Cdd:PHA03100 177 YLLSYGVPINIKDVYGFTPLHYAVYNNNPE------FVKYLLDLGANPNLVNKYGDTPL 229
Ank_4 pfam13637
Ankyrin repeats (many copies);
5-64 7.57e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 40.34  E-value: 7.57e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245    5 EGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRAryddpqNKARMVRYLL 64
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASN------GNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 21-81 8.14e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 8.14e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 120953245  21 ARLLLEGGAYVNEGDAQGETALMAACRaryddpQNKARMVRYLLEQGADPNIADRLGRTAL 81
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACA------NGHVQVVRVLLEFGADPTLLDKDGKTPL 152
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 60-134 1.54e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 1.54e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 120953245  60 VRYLLEQGADPNIADRLGRTaLMHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLDAC 134
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRT-PLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHS 171
PHA03095 PHA03095
ankyrin-like protein; Provisional
 24-81 2.75e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.47  E-value: 2.75e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 120953245  24 LLEGGAYVNEGDAQGETALMAAcrARYDDPqnkaRMVRYLLEQGADPNIADRLGRTAL 81
Cdd:PHA03095 243 LLIAGISINARNRYGQTPLHYA--AVFNNP----RACRRLIALGADINAVSSDGNTPL 294
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 24-132 5.98e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.26  E-value: 5.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245  24 LLEGGAYVNEGDAQGETALMAACRaryddpQNKARMVRYLLEQGADPNIADRLGRTALmHACAGGGGAAVASLLLAHGAD 103
Cdd:PHA02874 110 ILDCGIDVNIKDAELKTFLHYAIK------KGDLESIKMLFEYGADVNIEDDNGCYPI-HIAIKHNFFDIIKLLLEKGAY 182

                         90       100
                 ....*....|....*....|....*....
gi 120953245 104 PSVRDHAGASALVHALDRGDRETLATLLD 132
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGDYACIKLLID 211
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 46-131 1.60e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.02  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245  46 CRARYDDPQnKARMVRYLLEQGADPNIADR-LGRTALmHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDR 124
Cdd:PHA02878 137 DKKSKDDII-EAEITKLLLSYGADINMKDRhKGNTAL-HYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNK 214


                 ....*..
gi 120953245 125 ETLATLL 131
Cdd:PHA02878 215 PIVHILL 221
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-72 2.02e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.36  E-value: 2.02e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 120953245   9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMaaCRARYDdpqNKARMVRYLLEQGADPNI 72
Cdd:PHA02875 172 LIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAAL--CYAIEN---NKIDIVRLFIKRGADCNI 230
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 8-132 2.06e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.82  E-value: 2.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   8 ALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRAryddpQNKARMVRYLLEQGADPNIADRLGRTALMHACAG 87
Cdd:PHA02876 243 SLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQA-----PSLSRLVPKLLERGADVNAKNIKGETPLYLMAKN 317

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 120953245  88 GGGAAVASLLLAHGADPSVRDHAGASALVHA--LDRgDRETLATLLD 132
Cdd:PHA02876 318 GYDTENIRTLIMLGADVNAADRLYITPLHQAstLDR-NKDIVITLLE 363
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 9-131 2.62e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 40.62  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   9 LLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDpqnkarMVRYLLEQGADPNIADRLGRTALMHACAGG 88
Cdd:PLN03192 529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYED------CVLVLLKHACNVHIRDANGNTALWNAISAK 602

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 120953245  89 GGAAVASLL-LAHGADPsvrdHAGASALVHALDRGDRETLATLL 131
Cdd:PLN03192 603 HHKIFRILYhFASISDP----HAAGDLLCTAAKRNDLTAMKELL 642
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 38-72 2.67e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 2.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 120953245   38 GETALMAACRaryddpQNKARMVRYLLEQGADPNI 72
Cdd:pfam13606   2 GNTPLHLAAR------NGRLEIVKLLLENGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 13-81 2.81e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 2.81e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 120953245  13 VGQGKLRLARLLLEGGAYVNEGDAQGETALmaacraRYDDPQNKARMVRYLLEQGADPNIADRLGRTAL 81
Cdd:PHA02876 153 IQQDELLIAEMLLEGGADVNAKDIYCITPI------HYAAERGNAKMVNLLLSYGADVNIIALDDLSVL 215
Ank_4 pfam13637
Ankyrin repeats (many copies);
40-83 5.02e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 5.02e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 120953245   40 TALMAACRARYDDpqnkarMVRYLLEQGADPNIADRLGRTALMH 83
Cdd:pfam13637   3 TALHAAAASGHLE------LLRLLLEKGADINAVDGNGETALHF 40
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 54-132 7.25e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.89  E-value: 7.25e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 120953245  54 QNKARMVRYLLEQGADPNIADRLGRTALmHACAGGGGAAVASLLLAHGADPSVRDHAGASALVHALDRGDRETLATLLD 132
Cdd:PHA02876 155 QDELLIAEMLLEGGADVNAKDIYCITPI-HYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIID 232
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 3-103 7.74e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 38.71  E-value: 7.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 120953245   3 HTEGHALLRAVGQGKLRLARLLLEGGAYVNEGDAQGETALMAACRARYDDpqnkarMVRYLLEQGADPNIADRLGRTALM 82
Cdd:PHA02878 166 HKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKP------IVHILLENGASTDARDKCGNTPLH 239

                         90       100
                 ....*....|....*....|.
gi 120953245  83 HACAGGGGAAVASLLLAHGAD 103
Cdd:PHA02878 240 ISVGYCKDYDILKLLLEHGVD 260
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 37-72 9.10e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 33.72  E-value: 9.10e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 120953245    37 QGETALMAACRARYDDpqnkarMVRYLLEQGADPNI 72
Cdd:smart00248   1 DGRTPLHLAAENGNLE------VVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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