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Conserved domains on  [gi|70909314|ref|NP_001020745|]
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BPI fold containing family B, member 9B precursor [Mus musculus]

Protein Classification

LBP/BPI/CETP family protein( domain architecture ID 1919)

LBP (lipopolysaccharide-binding protein)/BPI (bactericidal permeability-increasing protein)/CETP (cholesteryl ester transfer protein) family protein similar to Mesocricetus auratus cholesteryl ester transfer protein and Equus burchellii antiquorum latherin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BPI super family cl00188
BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / ...
 223-340 6.90e-03

BPI/LBP/CETP domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) domain; binds to and neutralizes lipopolysaccharides from the outer membrane of Gram-negative bacteria.; Apolar pockets on the concave surface bind a molecule of phosphatidylcholine, primarily by interacting with their acyl chains; this suggests that the pockets may also bind the acyl chains of lipopolysaccharide.


The actual alignment was detected with superfamily member pfam01273:

Pssm-ID: 412206  Cd Length: 164  Bit Score: 37.67  E-value: 6.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70909314   223 IKDAIQEKVNEVVPDGIKEPLNDVLKMDIKDTLLELKVGQVTLDDMEINMEANGMQVLSMLTATIDGKGVLGPVISLLQF 302
Cdd:pfam01273   9 GLKALQKELQKITLPDILGEEGIKLLGKVLYNITNLKISNLQLPNLQLEFSPGGGLLLLIIPLTLKVSGKWPLRGSFLEL 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 70909314   303 EAKMDVMTTIAVASNNTQCVNLDAQDTHMHVKEMKIQL 340
Cdd:pfam01273  89 VVGVDITASLRLERDPQGRPTLVLSDCSSSPGSISISL 126
 
Name Accession Description Interval E-value
LBP_BPI_CETP pfam01273
LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP ...
 223-340 6.90e-03

LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.


Pssm-ID: 396022  Cd Length: 164  Bit Score: 37.67  E-value: 6.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70909314   223 IKDAIQEKVNEVVPDGIKEPLNDVLKMDIKDTLLELKVGQVTLDDMEINMEANGMQVLSMLTATIDGKGVLGPVISLLQF 302
Cdd:pfam01273   9 GLKALQKELQKITLPDILGEEGIKLLGKVLYNITNLKISNLQLPNLQLEFSPGGGLLLLIIPLTLKVSGKWPLRGSFLEL 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 70909314   303 EAKMDVMTTIAVASNNTQCVNLDAQDTHMHVKEMKIQL 340
Cdd:pfam01273  89 VVGVDITASLRLERDPQGRPTLVLSDCSSSPGSISISL 126
 
Name Accession Description Interval E-value
LBP_BPI_CETP pfam01273
LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP ...
 223-340 6.90e-03

LBP / BPI / CETP family, N-terminal domain; The N and C terminal domains of the LBP/BPI/CETP family are structurally similar.


Pssm-ID: 396022  Cd Length: 164  Bit Score: 37.67  E-value: 6.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 70909314   223 IKDAIQEKVNEVVPDGIKEPLNDVLKMDIKDTLLELKVGQVTLDDMEINMEANGMQVLSMLTATIDGKGVLGPVISLLQF 302
Cdd:pfam01273   9 GLKALQKELQKITLPDILGEEGIKLLGKVLYNITNLKISNLQLPNLQLEFSPGGGLLLLIIPLTLKVSGKWPLRGSFLEL 88

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 70909314   303 EAKMDVMTTIAVASNNTQCVNLDAQDTHMHVKEMKIQL 340
Cdd:pfam01273  89 VVGVDITASLRLERDPQGRPTLVLSDCSSSPGSISISL 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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