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Conserved domains on  [gi|4557845|ref|NP_001025|]
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ribonucleoside-diphosphate reductase subunit M2 isoform 2 [Homo sapiens]

Protein Classification

ribonucleoside-diphosphate reductase small subunit( domain architecture ID 10791385)

ribonucleoside-diphosphate reductase small subunit catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02492 PLN02492
ribonucleoside-diphosphate reductase
 70-389 0e+00

ribonucleoside-diphosphate reductase


:

Pssm-ID: 215272  Cd Length: 324  Bit Score: 620.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    70 EPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERF 149
Cdd:PLN02492   1 EPLLAENPDRFCMFPIKYPQIWEMYKKAEASFWTAEEVDLSADLKDWEKLTDDERHFISHVLAFFAASDGIVLENLAARF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   150 SQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIgDKEATYGERVVAFA 229
Cdd:PLN02492  81 MKEVQVPEARAFYGFQIAIENIHSEMYSLLLDTYIKDPKEKDRLFNAIETIPCVAKKADWALRWI-DSSASFAERLVAFA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   230 AVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALP 309
Cdd:PLN02492 160 CVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYSLLKNKLSEERVKEIVCEAVEIEKEFVCDALP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   310 VKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSS-----PTENSFT 384
Cdd:PLN02492 240 CALVGMNADLMSQYIEFVADRLLVALGYEKVYNVVNPFDWMELISLQGKTNFFEKRVGEYQKAGVMSSlngggADNHVFS 319


                 ....*
gi 4557845   385 LDADF 389
Cdd:PLN02492 320 LDEDF 324
 
Name Accession Description Interval E-value
PLN02492 PLN02492
ribonucleoside-diphosphate reductase
 70-389 0e+00

ribonucleoside-diphosphate reductase


Pssm-ID: 215272  Cd Length: 324  Bit Score: 620.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    70 EPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERF 149
Cdd:PLN02492   1 EPLLAENPDRFCMFPIKYPQIWEMYKKAEASFWTAEEVDLSADLKDWEKLTDDERHFISHVLAFFAASDGIVLENLAARF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   150 SQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIgDKEATYGERVVAFA 229
Cdd:PLN02492  81 MKEVQVPEARAFYGFQIAIENIHSEMYSLLLDTYIKDPKEKDRLFNAIETIPCVAKKADWALRWI-DSSASFAERLVAFA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   230 AVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALP 309
Cdd:PLN02492 160 CVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYSLLKNKLSEERVKEIVCEAVEIEKEFVCDALP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   310 VKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSS-----PTENSFT 384
Cdd:PLN02492 240 CALVGMNADLMSQYIEFVADRLLVALGYEKVYNVVNPFDWMELISLQGKTNFFEKRVGEYQKAGVMSSlngggADNHVFS 319


                 ....*
gi 4557845   385 LDADF 389
Cdd:PLN02492 320 LDEDF 324
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
79-346 3.58e-157

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 443.09  E-value: 3.58e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845     79 RFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEA 158
Cdd:pfam00268   1 RFNLNPIKYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKKLSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTPEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    159 RCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSG 238
Cdd:pfam00268  81 RAFYGFQAFMENIHSESYSYILDTLGKDPEEIDELFNWIETNPALQKKAEWILKWYQDFDSDFLERLVAFAILEGIFFYS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    239 SFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLV-------HKPSEERVREIIINAVRIEQEFLTEALPVK 311
Cdd:pfam00268 161 GFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLKeenpeleTKELKEEVYDLIKEAVELEKEFLDDALPVG 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 4557845    312 LIGMNCTLMKQYIEFVADRLMLELGFSKVFRVE-NP 346
Cdd:pfam00268 241 LLGMNAEDVKQYIEYVADRRLMNLGYEKLYNVEvNP 276
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 80-355 4.70e-144

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 410.48  E-value: 4.70e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   80 FVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEAR 159
Cdd:cd01049   1 FNLNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEKLTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIPEAR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  160 CFYGFQIAMENIHSEMYSLLIDTYIKDPkEREFLFNAIETMPCVKKKADWALRWIGD----KEATYGERVVAFAAVEGIF 235
Cdd:cd01049  81 AFYGFQAFMENIHSESYSYILDTLGKDE-ERDELFEAIETDPALKKKADWILRWYDNlddnTKESFAERLVAFAILEGIF 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  236 FSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHK-------PSEERVREIIINAVRIEQEFLTEAL 308
Cdd:cd01049 160 FYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNEnpelfteEFKEEVYELIKEAVELEKEFARDLL 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4557845  309 PVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRV--ENPFDFMENISL 355
Cdd:cd01049 240 PDGILGLNKEDMKQYIEYVANRRLENLGLEKLFNVedKNPFDWMELISD 288
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 68-377 1.64e-115

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 339.45  E-value: 1.64e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   68 EDEPLLRENP-RRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLV 146
Cdd:COG0208   1 LDEPIINGLTtNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWKKLSDDERHLIKRVLGFLTLLDSIQGNNLV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  147 ERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKErefLFNAIETMPCVKKKADWALRWIGDKEATYG---- 222
Cdd:COG0208  81 LALYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLDIDE---IFNWIEENPALQKKAEFILKYYDDLGTRETkkdl 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  223 -ERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFK-------HLVHKPSEERVREIII 294
Cdd:COG0208 158 lKSLVASVFLEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINtireenpELFTEELKEEIYELLK 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  295 NAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRV-ENPFDFMEN-ISLEGKTNFFEKRVGEYQRM 372
Cdd:COG0208 238 EAVELEKEYADDLFPDGILGLNAEDVKQYIRYIANKRLMNLGLEPLFEGdVNPFPWMSEgLDLNKKTDFFETRVTEYQKG 317


                ....*
gi 4557845  373 GVMSS 377
Cdd:COG0208 318 GVEST 322
 
Name Accession Description Interval E-value
PLN02492 PLN02492
ribonucleoside-diphosphate reductase
 70-389 0e+00

ribonucleoside-diphosphate reductase


Pssm-ID: 215272  Cd Length: 324  Bit Score: 620.91  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    70 EPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERF 149
Cdd:PLN02492   1 EPLLAENPDRFCMFPIKYPQIWEMYKKAEASFWTAEEVDLSADLKDWEKLTDDERHFISHVLAFFAASDGIVLENLAARF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   150 SQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIgDKEATYGERVVAFA 229
Cdd:PLN02492  81 MKEVQVPEARAFYGFQIAIENIHSEMYSLLLDTYIKDPKEKDRLFNAIETIPCVAKKADWALRWI-DSSASFAERLVAFA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   230 AVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEALP 309
Cdd:PLN02492 160 CVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYSLLKNKLSEERVKEIVCEAVEIEKEFVCDALP 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   310 VKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSS-----PTENSFT 384
Cdd:PLN02492 240 CALVGMNADLMSQYIEFVADRLLVALGYEKVYNVVNPFDWMELISLQGKTNFFEKRVGEYQKAGVMSSlngggADNHVFS 319


                 ....*
gi 4557845   385 LDADF 389
Cdd:PLN02492 320 LDEDF 324
PTZ00211 PTZ00211
ribonucleoside-diphosphate reductase small subunit; Provisional
 68-389 0e+00

ribonucleoside-diphosphate reductase small subunit; Provisional


Pssm-ID: 240315 [Multi-domain]  Cd Length: 330  Bit Score: 596.37  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    68 EDEPLLRENPRRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVE 147
Cdd:PTZ00211  10 EEEPLLKENPDRFVLFPIKYPDIWRMYKKAEASFWTAEEIDLGNDLKDWEKLNDGERHFIKHVLAFFAASDGIVLENLAQ 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   148 RFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDkEATYGERVVA 227
Cdd:PTZ00211  90 RFMREVQVPEARCFYGFQIAMENIHSETYSLLIDTYITDEEEKDRLFHAIETIPAIKKKAEWAAKWINS-SNSFAERLVA 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   228 FAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEERVREIIINAVRIEQEFLTEA 307
Cdd:PTZ00211 169 FAAVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLYSHLKNKLPRERVQEIIKEAVEIEREFICDA 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   308 LPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSSPTENSFTLDA 387
Cdd:PTZ00211 249 LPVDLIGMNSRLMAQYIEFVADRLLVALGVPKIYNSKNPFDWMDMISLQGKTNFFEKRVGEYQKAGVMAERTSKVFSLDA 328


                 ..
gi 4557845   388 DF 389
Cdd:PTZ00211 329 DF 330
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
79-346 3.58e-157

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 443.09  E-value: 3.58e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845     79 RFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEA 158
Cdd:pfam00268   1 RFNLNPIKYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKKLSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTPEA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    159 RCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSG 238
Cdd:pfam00268  81 RAFYGFQAFMENIHSESYSYILDTLGKDPEEIDELFNWIETNPALQKKAEWILKWYQDFDSDFLERLVAFAILEGIFFYS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    239 SFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLV-------HKPSEERVREIIINAVRIEQEFLTEALPVK 311
Cdd:pfam00268 161 GFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLKeenpeleTKELKEEVYDLIKEAVELEKEFLDDALPVG 240

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 4557845    312 LIGMNCTLMKQYIEFVADRLMLELGFSKVFRVE-NP 346
Cdd:pfam00268 241 LLGMNAEDVKQYIEYVADRRLMNLGYEKLYNVEvNP 276
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 80-355 4.70e-144

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 410.48  E-value: 4.70e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   80 FVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEAR 159
Cdd:cd01049   1 FNLNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEKLTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIPEAR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  160 CFYGFQIAMENIHSEMYSLLIDTYIKDPkEREFLFNAIETMPCVKKKADWALRWIGD----KEATYGERVVAFAAVEGIF 235
Cdd:cd01049  81 AFYGFQAFMENIHSESYSYILDTLGKDE-ERDELFEAIETDPALKKKADWILRWYDNlddnTKESFAERLVAFAILEGIF 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  236 FSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHK-------PSEERVREIIINAVRIEQEFLTEAL 308
Cdd:cd01049 160 FYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNEnpelfteEFKEEVYELIKEAVELEKEFARDLL 239

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 4557845  309 PVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRV--ENPFDFMENISL 355
Cdd:cd01049 240 PDGILGLNKEDMKQYIEYVANRRLENLGLEKLFNVedKNPFDWMELISD 288
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 68-377 1.64e-115

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 339.45  E-value: 1.64e-115
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   68 EDEPLLRENP-RRFVIFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLV 146
Cdd:COG0208   1 LDEPIINGLTtNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWKKLSDDERHLIKRVLGFLTLLDSIQGNNLV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  147 ERFSQEVQITEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKErefLFNAIETMPCVKKKADWALRWIGDKEATYG---- 222
Cdd:COG0208  81 LALYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLDIDE---IFNWIEENPALQKKAEFILKYYDDLGTRETkkdl 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  223 -ERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFK-------HLVHKPSEERVREIII 294
Cdd:COG0208 158 lKSLVASVFLEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINtireenpELFTEELKEEIYELLK 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  295 NAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFRV-ENPFDFMEN-ISLEGKTNFFEKRVGEYQRM 372
Cdd:COG0208 238 EAVELEKEYADDLFPDGILGLNAEDVKQYIRYIANKRLMNLGLEPLFEGdVNPFPWMSEgLDLNKKTDFFETRVTEYQKG 317


                ....*
gi 4557845  373 GVMSS 377
Cdd:COG0208 318 GVEST 322
PRK07209 PRK07209
ribonucleotide-diphosphate reductase subunit beta; Validated
 82-376 2.84e-48

ribonucleotide-diphosphate reductase subunit beta; Validated


Pssm-ID: 235968  Cd Length: 369  Bit Score: 167.48  E-value: 2.84e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    82 IFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWES---LKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEA 158
Cdd:PRK07209  51 LVPFKYKWAWEKYLAGCANHWMPQEVNMSRDIALWKSpngLTEDERRIVKRNLGFFSTADSLVANNIVLAIYRHITNPEC 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   159 RCFYGFQIAMENIHSEMYSLLIDTYIKDPKErefLFNAIETMPCVKKKADWAL---RWIGDKEATYG---------ERVV 226
Cdd:PRK07209 131 RQYLLRQAFEEAIHTHAYQYIVESLGLDEGE---IFNMYHEVPSIRAKDEFLIpftRSLTDPNFKTGtpendqkllRNLI 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   227 AFAAV-EGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFK-------HLVHKPSEERVREIIINAVR 298
Cdd:PRK07209 208 AFYCImEGIFFYVGFTQILSLGRQNKMTGIAEQYQYILRDESMHLNFGIDLINqiklenpHLWTAEFQAEIRELIKEAVE 287

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   299 IEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFSKVFR-VENPFDFM-ENISLEGKTNFFEKRVGEYQRMGVMS 376
Cdd:PRK07209 288 LEYRYARDTMPRGVLGLNASMFKDYLRFIANRRLQQIGLKPQYPgTENPFPWMsEMIDLKKEKNFFETRVIEYQTGGALS 367
nrdF PRK09614
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 84-372 2.06e-42

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 236591 [Multi-domain]  Cd Length: 324  Bit Score: 150.75  E-value: 2.06e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    84 PIEY---HDIWqmyKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARC 160
Cdd:PRK09614  16 KIEDpwdYEAW---KRLTANFWLPEEVPLSNDLKDWKKLSDEEKNLYTRVFGGLTLLDTLQNNNGMPNLMPDITTPEEEA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   161 FYGFQIAMENIHSEMYSLLIDTyIKDPKEREFLFNAIETMPCVKKKADWALRWIGD-KEATYGERVVAFAAVEGIFFSGS 239
Cdd:PRK09614  93 VLANIAFMEAVHAKSYSYIFST-LCSPEEIDEAFEWAEENPYLQKKADIIQDFYEPlKKKILRKAAVASVFLEGFLFYSG 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   240 FASIFWLKKRGLMPGltfSNELIS---RDEGLHCDFACLMFKHLVHKPSE-------ERVREIIINAVRIEQEFLTEALP 309
Cdd:PRK09614 172 FYYPLYLARQGKMTG---TAQIIRliiRDESLHGYYIGYLFQEGLEELPEleqeelkDEIYDLLYELYENEEAYTELLYD 248

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4557845   310 VklIGmNCTLMKQYIEFVADRLMLELGFSKVF--RVENPFDFMENISLEG--KTNFFEKRVGEYQRM 372
Cdd:PRK09614 249 I--VG-LAEDVKKYIRYNANKRLMNLGLEPLFpeEEEVNPIWLNGLSNNAdeNHDFFEGKGTSYVKG 312
PRK12759 PRK12759
bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional
 84-380 3.57e-24

bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional


Pssm-ID: 139206 [Multi-domain]  Cd Length: 410  Bit Score: 102.80  E-value: 3.57e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    84 PIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWESLK--PEERYFISHVLAFFAASDGIVNENLVERFSQEVQITEARCF 161
Cdd:PRK12759 102 PFNYPWAVDLTVKHEKAHWIEDEIDLSEDVTDWKNGKitKVEKEYITNILRLFTQSDVAVGQNYYDQFIPLFKNNEIRNM 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   162 YGFQIAMENIHSEMYSLLIDTY-IKDPKEREFLfnaieTMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSF 240
Cdd:PRK12759 182 LGSFAAREGIHQRAYALLNDTLgLPDSEYHAFL-----EYKAMTDKIDFMMDADPTTRRGLGLCLAKTVFNEGVALFASF 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   241 ASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFK-------HLVHKPSEERVREIIINAVRIEQEFLTEALPVKLI 313
Cdd:PRK12759 257 AMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRiycqenpYIVDNEFKKEIYLMASKAVELEDRFIELAYELGTI 336

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4557845   314 -GMNCTLMKQYIEFVADRLMLELGFSKVFRVE-NPFDFMENIsLEG--KTNFFEKRVGEYQRMGVMSSPTE 380
Cdd:PRK12759 337 eGLKADEVKQYIRHITDRRLNQLGLKEIYNIEkNPLTWLEWI-LNGadHTNFFENRVTEYEVAGLTGSWDE 406
RNRR2_Rv0233_like cd07911
Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Rv0233 is a Mycobacterium ...
 92-336 2.70e-09

Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Rv0233 is a Mycobacterium tuberculosis ribonucleotide reductase R2 protein with a heterodinuclear manganese/iron-carboxylate cofactor located in its metal center. The Rv0233-like family may represent a structural/functional counterpart of the evolutionary ancestor of the RNRR2's (Ribonucleotide Reductase, R2/beta subunit) and the bacterial multicomponent monooxygenases. RNRR2s belong to a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in prokaryotes and archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites.


Pssm-ID: 153120  Cd Length: 280  Bit Score: 57.74  E-value: 2.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   92 QMYKKAEA-SFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVE---------RFSQEVQIT----- 156
Cdd:cd07911  11 KLFEKGKRkGFWNPADIDFSQDREDWEQLSEEERDLALRLCAGFIAGEEAVTLDLLPlmmamaaegRLEEEMYLTqflfe 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  157 EARcfygfqiameniHSEMYSLLID---------TYIKDPKEREF---LFNAIEtmpcvKKKADWALRWIGDKEATYGER 224
Cdd:cd07911  91 EAK------------HTDFFRRWLDavgvsddlsDLHTAVYREPFyeaLPYAEL-----RLYLDASPAAQVRASVTYNMI 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845  225 VVAFAAVEGIFfsgSFASIfwLKKRGLMPGLTFSNELISRDEGLHCDFAC-LMFKHLVHKPS-----EERVREIIINAVR 298
Cdd:cd07911 154 VEGVLAETGYY---AWRTI--CEKRGILPGMQEGIRRLGDDESRHIAWGTfTCRRLVAADDAnwdvfEERMNELVPHALG 228

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 4557845  299 IEQEfLTEALPVKLIGMNCTLMKQYiefVADRLMLELG 336
Cdd:cd07911 229 LIDE-IFELYDEMPFGLDPDELMQY---AVDQFQRRLG 262
PRK08326 PRK08326
R2-like ligand-binding oxidase;
93-336 3.16e-09

R2-like ligand-binding oxidase;


Pssm-ID: 236242  Cd Length: 311  Bit Score: 57.70  E-value: 3.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    93 MYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNENLVE---------RFSQEVQIT-----EA 158
Cdd:PRK08326  30 LFAKGNAKFWNPADIDFSRDAEDWEKLSDEERDYATRLCAQFIAGEEAVTLDIQPlisamaaegRLEDEMYLTqfafeEA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   159 RcfygfqiameniHSEMYSLLIDT---------YIKD-PKEREFLFnaiETMPcvkkKADWALRwIGDKEATYGERVVAF 228
Cdd:PRK08326 110 K------------HTEAFRRWFDAvgvtedlsvYTDDnPSYRQIFY---EELP----AALNRLS-TDPSPENQVRASVTY 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   229 -AAVEGIF-FSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLV------HKPSEERVREIIINAVR-I 299
Cdd:PRK08326 170 nHVVEGVLaETGYYAWRKICVTRGILPGLQELVRRIGDDERRHIAWGTYTCRRLVaaddsnWDVFEERMNELLPLALGlI 249

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 4557845   300 EQEFLTEALPVKLIGMNCTLMkqyiEFVADRLMLELG 336
Cdd:PRK08326 250 DEIFALYGDQIPFELSNDEFV----DYAADRGQRRLG 282
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 101-352 1.44e-08

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 181647  Cd Length: 376  Bit Score: 56.12  E-value: 1.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   101 FWTAEEVDLSKDIQHWESLKPEERY-FISHvLAFFAASDGI----VN------------ENLVERFSqevqitearcfyg 163
Cdd:PRK09101  48 FWRPEEVDVSRDRIDYQALPEHEKHiFISN-LKYQTLLDSIqgrsPNvallplvsipelETWIETWS------------- 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   164 FQiamENIHSEMYSLLIDTYIKDPKErefLFNAIETMPCVKKKA---------------DWALRWIGD-----KEATYGE 223
Cdd:PRK09101 114 FS---ETIHSRSYTHIIRNIVNDPSV---VFDDIVTNEEILKRAkdissyyddliemtsYYHLLGEGThtvngKTVTVSL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   224 R---------VVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHL-----------VHK 283
Cdd:PRK09101 188 RelkkklylcLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLMrsgkddpemaeIAE 267

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4557845   284 PSEERVREIIINAVRIEQEFlTEALpVK---LIGMNCTLMKQYIEFVADRLMLELGFSKVFRVE-NPFDFMEN 352
Cdd:PRK09101 268 ECKQECYDLFVQAAEQEKEW-ADYL-FKdgsMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRsNPIPWINA 338
PRK13965 PRK13965
ribonucleotide-diphosphate reductase subunit beta; Provisional
 89-344 1.56e-07

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 184425 [Multi-domain]  Cd Length: 335  Bit Score: 52.47  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    89 DIWQmykKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIvnENLVERFSqevQITEAR-----CFYG 163
Cdd:PRK13965  37 EVWN---RVTQNFWLPEKVPVSNDLNSWRSLGEDWQQLITRTFTGLTLLDTV--QATVGDVA---QIPHSQtdheqVIYT 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   164 FQIAMENIHSEMYSLLIDTYIKDPKEREFLFNAIETmPCVKKKADWALR-WIGDKEAtygERVVAFAAVEGIFFSGSFAS 242
Cdd:PRK13965 109 NFAFMVAIHARSYGTIFSTLCSSEQIEEAHEWVVST-ESLQRRARVLIPyYTGDDPL---KSKVAAAMMPGFLLYGGFYL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   243 IFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPSEER-------VREIIINAVRIEQEFLTEalpvklIGM 315
Cdd:PRK13965 185 PFYLSARGKLPNTSDIIRLILRDKVIHNYYSGYKYQQKVARLSPEKqaemkafVFDLLYELIDLEKAYLRE------LYA 258

                        250       260       270
                 ....*....|....*....|....*....|..
gi 4557845   316 NCTLMKQYIEFV---ADRLMLELGFSKVFRVE 344
Cdd:PRK13965 259 GFDLAEDAIRFSlynAGKFLQNLGYESPFTEE 290
nrdF2 PRK13966
ribonucleotide-diphosphate reductase subunit beta; Provisional
 92-341 3.84e-07

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140022  Cd Length: 324  Bit Score: 51.26  E-value: 3.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    92 QMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASDGIVNE-NLVERFSQEVQITEARCFYGFQIaMEN 170
Cdd:PRK13966  26 EVWDRLTGNFWLPEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTvGAVSLIPDALTPHEEAVLTNIAF-MES 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   171 IHSEMYSLLIDTyIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATygERVVAFAAVEG-IFFSGSFASIFWlKKR 249
Cdd:PRK13966 105 VHAKSYSQIFST-LCSTAEIDDAFRWSEENRNLQRKAEIVLQYYRGDEPL--KRKVASTLLESfLFYSGFYLPMYW-SSR 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   250 GLMPGLTFSNELISRDEGLHCDFACLMFKH---LVHKPSEERVR--------EIIINAVRIEQEFLTEalpvklIGMNcT 318
Cdd:PRK13966 181 AKLTNTADMIRLIIRDEAVHGYYIGYKFQRglaLVDDVTRAELKdytyellfELYDNEVEYTQDLYDE------VGLT-E 253

                        250       260
                 ....*....|....*....|...
gi 4557845   319 LMKQYIEFVADRLMLELGFSKVF 341
Cdd:PRK13966 254 DVKKFLRYNANKALMNLGYEALF 276
nrdF1 PRK13967
ribonucleotide-diphosphate reductase subunit beta; Provisional
 92-269 5.14e-06

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140023  Cd Length: 322  Bit Score: 47.80  E-value: 5.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845    92 QMYKKAEASFWTAEEVDLSKDIQHWESLKPEERYFISHVLAFFAASD-GIVNENLVERFSQEVQITEARCFYGFQIaMEN 170
Cdd:PRK13967  24 QVWERLTGNFWLPEKIPLSNDLASWQTLSSTEQQTTIRVFTGLTLLDtAQATVGAVAMIDDAVTPHEEAVLTNMAF-MES 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557845   171 IHSEMYSLLIDTyIKDPKEREFLFNAIETMPCVKKKADWALRWIGDKEATygERVVAFAAVEG-IFFSGSFASIFWlKKR 249
Cdd:PRK13967 103 VHAKSYSSIFST-LCSTKQIDDAFDWSEQNPYLQRKAQIIVDYYRGDDAL--KRKASSVMLESfLFYSGFYLPMYW-SSR 178

                        170       180
                 ....*....|....*....|
gi 4557845   250 GLMPGLTFSNELISRDEGLH 269
Cdd:PRK13967 179 GKLTNTADLIRLIIRDEAVH 198
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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