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Conserved domains on  [gi|72534670|ref|NP_001026859|]
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phospholipase A-2-activating protein isoform 1 [Homo sapiens]

Protein Classification

WD repeat PLAP family protein( domain architecture ID 10078051)

WD repeat PLAP family protein containing WD40, PFU, and PUL domains, similar to vertebrate phospholipase A-2-activating protein (PLAP or PLAA), a ubiquitin-binding protein involved in protein ubiquitination, sorting and degradation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 536-789 1.76e-81

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


:

Pssm-ID: 462428  Cd Length: 261  Bit Score: 261.50  E-value: 1.76e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   536 PKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKptVQQLQILWKAI-NCPEDIVFPAL 614
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPKVLALSPEELATLEALLSFLESSSSAS--EADIELLLKILtSWPPEDRFPAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   615 DILRLSIKHPSVNENFCNEKEGaQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGS 694
Cdd:pfam08324  79 DLLRLLALDPRVAAYFAEEEGG-KTISTLLSLLISSGLYALRMLALRLLCNLFSSPLGRQLLLSHFDSILSTLASLLSSS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   695 ----NKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVV----QDLEATFRLLVALGTLI--SDDSNAVQLAK 764
Cdd:pfam08324 158 lldsNKNLRIALATLLLNYAVLLHKEKSPLSEEDQVELLAALLEALsteeEDSEALYRLLVALGTLVyaPDGEVLADLAQ 237

                         250       260
                  ....*....|....*....|....*
gi 72534670   765 SLGVDSQIKKYSSVSEPaKVSECCR 789
Cdd:pfam08324 238 VLDAASWVKKAKKKKEP-RIKEVGS 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-297 1.58e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.11  E-value: 1.58e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  10 LSCSLRGHELDVRGlVCCAYPPGAFVSVSRDRTTRLWapDSPNRSFteMHCMSGHSNFVSCVCIIPSSDiyphgLIATGG 89
Cdd:cd00200   1 LRRTLKGHTGGVTC-VAFSPDGKLLATGSGDGTIKVW--DLETGEL--LRTLKGHTGPVRDVAASADGT-----YLASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  90 NDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLM 166
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAfSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670 167 LTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAIL-SETEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPN 242
Cdd:cd00200 151 ASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSPD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 72534670 243 CRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNG-DIVVGASDGIIRVF 297
Cdd:cd00200 231 GYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-458 3.38e-58

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


:

Pssm-ID: 462670  Cd Length: 111  Bit Score: 193.51  E-value: 3.38e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   346 PGTREGQTRLIRDGE-KVEAYQWSVSEGRWIKIGDVVGSSGanqqTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSD 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNgVVEAYQWSAAEQQWEKIGDVVGSAG----SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGD 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 72534670   425 DPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQ 458
Cdd:pfam09070  77 NPYEAAQKFLARNELPQSYLDQVVNFIIKNTGGV 110
 
Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 536-789 1.76e-81

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 261.50  E-value: 1.76e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   536 PKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKptVQQLQILWKAI-NCPEDIVFPAL 614
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPKVLALSPEELATLEALLSFLESSSSAS--EADIELLLKILtSWPPEDRFPAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   615 DILRLSIKHPSVNENFCNEKEGaQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGS 694
Cdd:pfam08324  79 DLLRLLALDPRVAAYFAEEEGG-KTISTLLSLLISSGLYALRMLALRLLCNLFSSPLGRQLLLSHFDSILSTLASLLSSS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   695 ----NKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVV----QDLEATFRLLVALGTLI--SDDSNAVQLAK 764
Cdd:pfam08324 158 lldsNKNLRIALATLLLNYAVLLHKEKSPLSEEDQVELLAALLEALsteeEDSEALYRLLVALGTLVyaPDGEVLADLAQ 237

                         250       260
                  ....*....|....*....|....*
gi 72534670   765 SLGVDSQIKKYSSVSEPaKVSECCR 789
Cdd:pfam08324 238 VLDAASWVKKAKKKKEP-RIKEVGS 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-297 1.58e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.11  E-value: 1.58e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  10 LSCSLRGHELDVRGlVCCAYPPGAFVSVSRDRTTRLWapDSPNRSFteMHCMSGHSNFVSCVCIIPSSDiyphgLIATGG 89
Cdd:cd00200   1 LRRTLKGHTGGVTC-VAFSPDGKLLATGSGDGTIKVW--DLETGEL--LRTLKGHTGPVRDVAASADGT-----YLASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  90 NDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLM 166
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAfSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670 167 LTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAIL-SETEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPN 242
Cdd:cd00200 151 ASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSPD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 72534670 243 CRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNG-DIVVGASDGIIRVF 297
Cdd:cd00200 231 GYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-458 3.38e-58

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 193.51  E-value: 3.38e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   346 PGTREGQTRLIRDGE-KVEAYQWSVSEGRWIKIGDVVGSSGanqqTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSD 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNgVVEAYQWSAAEQQWEKIGDVVGSAG----SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGD 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 72534670   425 DPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQ 458
Cdd:pfam09070  77 NPYEAAQKFLARNELPQSYLDQVVNFIIKNTGGV 110
WD40 COG2319
WD40 repeat [General function prediction only];
13-296 9.34e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 9.34e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  13 SLRGHELDVRGLVCcAYPPGAFVSVSRDRTTRLWAPDSPNRSFTemhcMSGHSNFVSCVCIIPSSDIyphglIATGGNDH 92
Cdd:COG2319  73 TLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLATGLLLRT----LTGHTGAVRSVAFSPDGKT-----LASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  93 NICIFSLDSPMPLYILKGHKNTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLML 167
Cdd:COG2319 143 TVRLWDLATGKLLRTLTGHSGAVTSVAfspDGK--LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670 168 TGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNC 243
Cdd:COG2319 221 SGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDG 300

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 72534670 244 RDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNGD-IVVGASDGIIRV 296
Cdd:COG2319 301 KLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRL 356
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-179 1.15e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.15e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 72534670    142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK 179
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-178 2.35e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.35e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 72534670   142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW 178
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 7-207 1.87e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670    7 RYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPnrsfTEMHCMSGHSNFvsCVCIIPSSDIYPhglIA 86
Cdd:PLN00181 564 RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQG----VSIGTIKTKANI--CCVQFPSESGRS---LA 634

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   87 TGGNDHNICIFSLDSP-MPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVW--------LNDKCMMTLQGHTAAVWAV 157
Cdd:PLN00181 635 FGSADHKVYYYDLRNPkLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsisgINETPLHSFMGHTNVKNFV 714

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 72534670  158 KILPEQGLMLTGSADKTVKLWKAGRCERTFS---GHEDCVRGLAILSETEFLS 207
Cdd:PLN00181 715 GLSVSDGYIATGSETNEVFVYHKAFPMPVLSykfKTIDPVSGLEVDDASQFIS 767
 
Name Accession Description Interval E-value
PUL pfam08324
PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated ...
 536-789 1.76e-81

PUL domain; The PUL (PLAP, Ufd3p and Lub1p) domain is a novel alpha-helical Ub-associated domain. It directly binds to Cdc48, a chaperone-like AAA ATPase that collects ubiquitylated substrates.


Pssm-ID: 462428  Cd Length: 261  Bit Score: 261.50  E-value: 1.76e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   536 PKKEAVTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKptVQQLQILWKAI-NCPEDIVFPAL 614
Cdd:pfam08324   1 PQKTYLSFKKANLDKILKKLGEFNGGEPKVLALSPEELATLEALLSFLESSSSAS--EADIELLLKILtSWPPEDRFPAL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   615 DILRLSIKHPSVNENFCNEKEGaQFSSHLINLLNPKGKPANQLLALRTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGS 694
Cdd:pfam08324  79 DLLRLLALDPRVAAYFAEEEGG-KTISTLLSLLISSGLYALRMLALRLLCNLFSSPLGRQLLLSHFDSILSTLASLLSSS 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   695 ----NKNIHIALATLALNYSVCFHKDHNIEGKAQCLSLISTILEVV----QDLEATFRLLVALGTLI--SDDSNAVQLAK 764
Cdd:pfam08324 158 lldsNKNLRIALATLLLNYAVLLHKEKSPLSEEDQVELLAALLEALsteeEDSEALYRLLVALGTLVyaPDGEVLADLAQ 237

                         250       260
                  ....*....|....*....|....*
gi 72534670   765 SLGVDSQIKKYSSVSEPaKVSECCR 789
Cdd:pfam08324 238 VLDAASWVKKAKKKKEP-RIKEVGS 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-297 1.58e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.11  E-value: 1.58e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  10 LSCSLRGHELDVRGlVCCAYPPGAFVSVSRDRTTRLWapDSPNRSFteMHCMSGHSNFVSCVCIIPSSDiyphgLIATGG 89
Cdd:cd00200   1 LRRTLKGHTGGVTC-VAFSPDGKLLATGSGDGTIKVW--DLETGEL--LRTLKGHTGPVRDVAASADGT-----YLASGS 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  90 NDHNICIFSLDSPMPLYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLM 166
Cdd:cd00200  71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAfSPDGRILSSSSRDKTIKVWdvETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670 167 LTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAIL-SETEFLSCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPN 242
Cdd:cd00200 151 ASSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSpDGEKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSPD 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 72534670 243 CRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNG-DIVVGASDGIIRVF 297
Cdd:cd00200 231 GYLLASGSEDGTIRVWdlRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIW 288
PFU pfam09070
PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ...
 346-458 3.38e-58

PFU (PLAA family ubiquitin binding); This domain is found N terminal to pfam08324 and binds to ubiquitin.


Pssm-ID: 462670  Cd Length: 111  Bit Score: 193.51  E-value: 3.38e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   346 PGTREGQTRLIRDGE-KVEAYQWSVSEGRWIKIGDVVGSSGanqqTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNTSD 424
Cdd:pfam09070   1 PGKKEGQVKMVREGNgVVEAYQWSAAEQQWEKIGDVVGSAG----SSQKKEYEGKEYDYVFDVDIEDGKPPLKLPYNVGD 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 72534670   425 DPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQ 458
Cdd:pfam09070  77 NPYEAAQKFLARNELPQSYLDQVVNFIIKNTGGV 110
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-259 1.69e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 184.46  E-value: 1.69e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   9 RLSCSLRGHELDVRGLVCCAYPPgAFVSVSRDRTTRLWAPDSPNRSFTemhcMSGHSNFVSCVCIIPSSDIyphglIATG 88
Cdd:cd00200  42 ELLRTLKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLETGECVRT----LTGHTSYVSSVAFSPDGRI-----LSSS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  89 GNDHNICIFSLDSPMPLYILKGHKNTVCSLSSGKFGTLL-SGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGL 165
Cdd:cd00200 112 SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVaSSSQDGTIKLWdlRTGKCVATLTGHTGEVNSVAFSPDGEK 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670 166 MLTGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFP 241
Cdd:cd00200 192 LLSSSSDGTIKLWdlSTGKCLGTLRGHENGVNSVAFSPDGYLLaSGSEDGTIRVWDLrTGECVQTLSGHTNSVTSLAWSP 271

                       250
                ....*....|....*...
gi 72534670 242 NCRDFVTTAEDRSLRIWK 259
Cdd:cd00200 272 DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
13-296 9.34e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 9.34e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  13 SLRGHELDVRGLVCcAYPPGAFVSVSRDRTTRLWAPDSPNRSFTemhcMSGHSNFVSCVCIIPSSDIyphglIATGGNDH 92
Cdd:COG2319  73 TLLGHTAAVLSVAF-SPDGRLLASASADGTVRLWDLATGLLLRT----LTGHTGAVRSVAFSPDGKT-----LASGSADG 142

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  93 NICIFSLDSPMPLYILKGHKNTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGLML 167
Cdd:COG2319 143 TVRLWDLATGKLLRTLTGHSGAVTSVAfspDGK--LLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKLLA 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670 168 TGSADKTVKLW--KAGRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNC 243
Cdd:COG2319 221 SGSADGTVRLWdlATGKLLRTLTGHSGSVRSVAFSPDGRLLaSGSADGTVRLWDLaTGELLRTLTGHSGGVNSVAFSPDG 300

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 72534670 244 RDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIWCCCVLDNGD-IVVGASDGIIRV 296
Cdd:COG2319 301 KLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVRSVAFSPDGKtLASGSDDGTVRL 356
WD40 COG2319
WD40 repeat [General function prediction only];
13-258 1.13e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.85  E-value: 1.13e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  13 SLRGHELDVRGLvccAY-PPGAF-VSVSRDRTTRLWAPDSPNRSFTemhcMSGHSNFVSCVCIIPSSDiyphgLIATGGN 90
Cdd:COG2319 157 TLTGHSGAVTSV---AFsPDGKLlASGSDDGTVRLWDLATGKLLRT----LTGHTGAVRSVAFSPDGK-----LLASGSA 224

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  91 DHNICIFSLDSPMPLYILKGHKNTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILPEQGL 165
Cdd:COG2319 225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAfspDGR--LLASGSADGTVRLWdlATGELLRTLTGHSGGVNSVAFSPDGKL 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670 166 MLTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAILSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFP 241
Cdd:COG2319 303 LASGSDDGTVRLWDLatGKLLRTLTGHTGAVRSVAFSPDGKTLaSGSDDGTVRLWDLaTGELLRTLTGHTGAVTSVAFSP 382

                       250
                ....*....|....*..
gi 72534670 242 NCRDFVTTAEDRSLRIW 258
Cdd:COG2319 383 DGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
9-180 1.21e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 116.16  E-value: 1.21e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   9 RLSCSLRGHELDVRGLvccAYPP-GAF-VSVSRDRTTRLWAPDSPNRSFTemhcMSGHSNFVSCVCIIPSSDiyphgLIA 86
Cdd:COG2319 237 KLLRTLTGHSGSVRSV---AFSPdGRLlASGSADGTVRLWDLATGELLRT----LTGHSGGVNSVAFSPDGK-----LLA 304

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  87 TGGNDHNICIFSLDSPMPLYILKGHKNTVCSLS---SGKfgTLLSGSWDTTAKVW--LNDKCMMTLQGHTAAVWAVKILP 161
Cdd:COG2319 305 SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAfspDGK--TLASGSDDGTVRLWdlATGELLRTLTGHTGAVTSVAFSP 382

                       170
                ....*....|....*....
gi 72534670 162 EQGLMLTGSADKTVKLWKA 180
Cdd:COG2319 383 DGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
124-297 8.99e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 107.69  E-value: 8.99e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670 124 GTLLSGSWDTTAKVWLND--KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKA--GRCERTFSGHEDCVRGLAI 199
Cdd:COG2319  49 ARLAAGAGDLTLLLLDAAagALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLatGLLLRTLTGHTGAVRSVAF 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670 200 LSETEFL-SCANDASIRRWQI-TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW--KHGECAQTIRLPAQSIW 275
Cdd:COG2319 129 SPDGKTLaSGSADGTVRLWDLaTGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWdlATGKLLRTLTGHTGAVR 208

                       170       180
                ....*....|....*....|...
gi 72534670 276 CCCVLDNGD-IVVGASDGIIRVF 297
Cdd:COG2319 209 SVAFSPDGKlLASGSADGTVRLW 231
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-179 1.15e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.15e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 72534670    142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWK 179
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-178 2.35e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.35e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 72534670   142 KCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLW 178
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 220-259 3.99e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 3.99e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 72534670    220 TGECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWK 259
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 7-207 1.87e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 1.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670    7 RYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPnrsfTEMHCMSGHSNFvsCVCIIPSSDIYPhglIA 86
Cdd:PLN00181 564 RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQG----VSIGTIKTKANI--CCVQFPSESGRS---LA 634

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670   87 TGGNDHNICIFSLDSP-MPLYILKGHKNTVCSLSSGKFGTLLSGSWDTTAKVW--------LNDKCMMTLQGHTAAVWAV 157
Cdd:PLN00181 635 FGSADHKVYYYDLRNPkLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWdlsmsisgINETPLHSFMGHTNVKNFV 714

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 72534670  158 KILPEQGLMLTGSADKTVKLWKAGRCERTFS---GHEDCVRGLAILSETEFLS 207
Cdd:PLN00181 715 GLSVSDGYIATGSETNEVFVYHKAFPMPVLSykfKTIDPVSGLEVDDASQFIS 767
WD40 COG2319
WD40 repeat [General function prediction only];
13-101 2.10e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 2.10e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 72534670  13 SLRGHELDVRGLvccAYPP--GAFVSVSRDRTTRLWAPDSPnrsfTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGN 90
Cdd:COG2319 325 TLTGHTGAVRSV---AFSPdgKTLASGSDDGTVRLWDLATG----ELLRTLTGHTGAVTSVAFSPDGR-----TLASGSA 392

                        90
                ....*....|.
gi 72534670  91 DHNICIFSLDS 101
Cdd:COG2319 393 DGTVRLWDLAT 403
WD40 pfam00400
WD domain, G-beta repeat;
221-258 7.33e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 7.33e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 72534670   221 GECLEVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIW 258
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
104-138 2.36e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.36e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 72534670   104 PLYILKGHKNTVCSLSSGKFGTLL-SGSWDTTAKVW 138
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLaSGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-98 8.12e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.12e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 72534670     54 SFTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGNDHNICIFS 98
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-----YLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-138 3.01e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 3.01e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 72534670    104 PLYILKGHKNTVCSLS-SGKFGTLLSGSWDTTAKVW 138
Cdd:smart00320   4 LLKTLKGHTGPVTSVAfSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
55-98 7.05e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 7.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 72534670    55 FTEMHCMSGHSNFVSCVCIIPSSDiyphgLIATGGNDHNICIFS 98
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-----LLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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